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Aliases for HNRNPUL2-BSCL2 Gene

Subcategory (RNA class) for HNRNPUL2-BSCL2 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for HNRNPUL2-BSCL2 Gene

  • HNRNPUL2-BSCL2 Readthrough (NMD Candidate) 2 3 5

External Ids for HNRNPUL2-BSCL2 Gene

Previous GeneCards Identifiers for HNRNPUL2-BSCL2 Gene

  • GC11U901839
  • GC11M062479
  • GC11M062491
  • GC11M062691
  • GC11M062697
  • GC11M062719
  • GC11M062730

Summaries for HNRNPUL2-BSCL2 Gene

Entrez Gene Summary for HNRNPUL2-BSCL2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U-like 2) and BSCL2 (Berardinelli-Seip congenital lipodystrophy 2 (seipin)) genes on chromosome 11. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Mar 2011]

GeneCards Summary for HNRNPUL2-BSCL2 Gene

HNRNPUL2-BSCL2 (HNRNPUL2-BSCL2 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. Diseases associated with HNRNPUL2-BSCL2 include Berardinelli-Seip Congenital Lipodystrophy. GO annotations related to this gene include nucleic acid binding and kinase activity. An important paralog of this gene is HNRNPUL2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPUL2-BSCL2 Gene

Genomics for HNRNPUL2-BSCL2 Gene

Regulatory Elements for HNRNPUL2-BSCL2 Gene

Enhancers for HNRNPUL2-BSCL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F062750 0.2 ENCODE 11.9 -23.7 -23726 0.4 POLR2A PRDM10 ZNF384 HNRNPUL2 HNRNPUL2-BSCL2 TTC9C TAF6L SLC3A2 SNHG1 SNORD22 AHNAK GANAB GC11M062755
GH11F062724 0.2 ENCODE 0.8 +0.2 215 6.2 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 TTC9C SCGB1D1 EEF1DP8 ENSG00000203520 IMMP1LP1 HNRNPUL2 EEF1G TAF6L LRRN4CL METTL12
GH11F062719 0.5 ENCODE 0.4 +7.5 7493 1.7 ZKSCAN8 MYNN TCF7 ZBTB33 TTC9C HNRNPUL2-BSCL2 PIR38618
GH11F062722 0.5 ENCODE 0.4 +5.2 5181 0.2 CTCF SAP130 TEAD1 TEAD4 ARID4B MNT RAD21 TEAD3 ZNF157 ZBTB33 HNRNPUL2-BSCL2 PIR38618
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HNRNPUL2-BSCL2 on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPUL2-BSCL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001570677 184 5601 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1

Genomic Location for HNRNPUL2-BSCL2 Gene

Chromosome:
11
Start:
62,690,262 bp from pter
End:
62,727,384 bp from pter
Size:
37,123 bases
Orientation:
Minus strand

Genomic View for HNRNPUL2-BSCL2 Gene

Genes around HNRNPUL2-BSCL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPUL2-BSCL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPUL2-BSCL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPUL2-BSCL2 Gene

Proteins for HNRNPUL2-BSCL2 Gene

  • Protein details for HNRNPUL2-BSCL2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BQZ7
    Recommended name:
    HCG2044799
    Protein Accession:
    H3BQZ7

    Protein attributes for HNRNPUL2-BSCL2 Gene

    Size:
    746 amino acids
    Molecular mass:
    84691 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HNRNPUL2-BSCL2 Gene

Post-translational modifications for HNRNPUL2-BSCL2 Gene

No Post-translational modifications

Other Protein References for HNRNPUL2-BSCL2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for HNRNPUL2-BSCL2 Gene

Domains & Families for HNRNPUL2-BSCL2 Gene

Protein Domains for HNRNPUL2-BSCL2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPUL2-BSCL2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HNRNPUL2-BSCL2 Gene

Function for HNRNPUL2-BSCL2 Gene

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HNRNPUL2-BSCL2 Gene

Localization for HNRNPUL2-BSCL2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HNRNPUL2-BSCL2 Gene

Pathways & Interactions for HNRNPUL2-BSCL2 Gene

SuperPathways for HNRNPUL2-BSCL2 Gene

No Data Available

Interacting Proteins for HNRNPUL2-BSCL2 Gene

Gene Ontology (GO) - Biological Process for HNRNPUL2-BSCL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HNRNPUL2-BSCL2 Gene

Transcripts for HNRNPUL2-BSCL2 Gene

mRNA/cDNA for HNRNPUL2-BSCL2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPUL2-BSCL2 Gene

No ASD Table

Relevant External Links for HNRNPUL2-BSCL2 Gene

GeneLoc Exon Structure for
HNRNPUL2-BSCL2
ECgene alternative splicing isoforms for
HNRNPUL2-BSCL2

Expression for HNRNPUL2-BSCL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNRNPUL2-BSCL2 Gene

genes like me logo Genes that share expression patterns with HNRNPUL2-BSCL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HNRNPUL2-BSCL2 Gene

Orthologs for HNRNPUL2-BSCL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPUL2-BSCL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HNRNPUL2 35
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Hnrnpul2 35
  • 92 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii HNRNPUL2 35
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30122 35
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y41E3.11 35
  • 8 (a)
OneToMany
Species where no ortholog for HNRNPUL2-BSCL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HNRNPUL2-BSCL2 Gene

ENSEMBL:
Gene Tree for HNRNPUL2-BSCL2 (if available)
TreeFam:
Gene Tree for HNRNPUL2-BSCL2 (if available)

Paralogs for HNRNPUL2-BSCL2 Gene

Paralogs for HNRNPUL2-BSCL2 Gene

(5) SIMAP similar genes for HNRNPUL2-BSCL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HNRNPUL2-BSCL2: view

Variants for HNRNPUL2-BSCL2 Gene

Sequence variations from dbSNP and Humsavar for HNRNPUL2-BSCL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs137852970 Pathogenic 62,694,594(-) GTGGC(C/T)GAATC nc-transcript-variant, reference, stop-gained
rs137852971 Pathogenic 62,692,413(-) ATGGA(C/G)CCTAC nc-transcript-variant, reference, missense
rs137852972 Pathogenic 62,702,499(-) TGCCA(A/G)TGTCT nc-transcript-variant, reference, missense
rs137852973 Pathogenic 62,702,493(-) TGTCT(C/T)GCTGA nc-transcript-variant, reference, missense
rs137852974 Pathogenic 62,691,132(-) ACATC(C/T)GAAAA nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for HNRNPUL2-BSCL2 Gene

Variant ID Type Subtype PubMed ID
nsv348 CNV deletion 18451855
nsv555174 CNV gain 21841781
nsv832182 CNV gain+loss 17160897

Relevant External Links for HNRNPUL2-BSCL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPUL2-BSCL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HNRNPUL2-BSCL2 Gene

Disorders for HNRNPUL2-BSCL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNRNPUL2-BSCL2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
berardinelli-seip congenital lipodystrophy
  • berardinelli-seip congenital generalized lipodystrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HNRNPUL2-BSCL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPUL2-BSCL2
genes like me logo Genes that share disorders with HNRNPUL2-BSCL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPUL2-BSCL2 Gene

Publications for HNRNPUL2-BSCL2 Gene

  1. Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. (PMID: 24554482) Leger P.D. … Haas D.W. (J. Neurovirol. 2014) 3 64
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64

Products for HNRNPUL2-BSCL2 Gene

Sources for HNRNPUL2-BSCL2 Gene

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