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Aliases for HNRNPUL2-BSCL2 Gene

Subcategory (RNA class) for HNRNPUL2-BSCL2 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for HNRNPUL2-BSCL2 Gene

  • HNRNPUL2-BSCL2 Readthrough (NMD Candidate) 2 3 5

External Ids for HNRNPUL2-BSCL2 Gene

Previous GeneCards Identifiers for HNRNPUL2-BSCL2 Gene

  • GC11U901839
  • GC11M062479
  • GC11M062491
  • GC11M062691
  • GC11M062697
  • GC11M062719
  • GC11M062730
  • GC11M062742

Summaries for HNRNPUL2-BSCL2 Gene

Entrez Gene Summary for HNRNPUL2-BSCL2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U-like 2) and BSCL2 (Berardinelli-Seip congenital lipodystrophy 2 (seipin)) genes on chromosome 11. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Mar 2011]

GeneCards Summary for HNRNPUL2-BSCL2 Gene

HNRNPUL2-BSCL2 (HNRNPUL2-BSCL2 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. Diseases associated with HNRNPUL2-BSCL2 include Berardinelli-Seip Congenital Lipodystrophy. GO annotations related to this gene include nucleic acid binding and kinase activity. An important paralog of this gene is HNRNPUL2.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPUL2-BSCL2 Gene

Genomics for HNRNPUL2-BSCL2 Gene

Regulatory Elements for HNRNPUL2-BSCL2 Gene

Enhancers for HNRNPUL2-BSCL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G062750 0.5 ENCODE 12 -23.7 -23726 0.4 POLR2A PRDM10 ZNF384 TTC9C HNRNPUL2-BSCL2 HNRNPUL2 TAF6L SLC3A2 SNORD22 SNHG1 AHNAK GANAB PIR37929
GH11G062724 1.4 ENCODE dbSUPER 0.7 +0.2 215 6.2 CREB3L1 MLX DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 TTC9C IMMP1LP1 HNRNPUL2 EEF1G GANAB HNRNPUL2-BSCL2 PIR38618
GH11G062722 0.7 ENCODE 0.4 +5.2 5181 0.2 CTCF SAP130 TEAD1 TEAD4 ARID4B SIN3A MNT RAD21 TEAD3 ZNF157 HNRNPUL2-BSCL2 PIR38618
GH11G062719 0.6 ENCODE 0.4 +7.5 7493 1.7 FOXA2 SMAD5 ZKSCAN8 MYNN TCF7 ZBTB33 TTC9C HNRNPUL2-BSCL2 PIR38618
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HNRNPUL2-BSCL2 on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPUL2-BSCL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040468 -16 4801 CREB3L1 MLX DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1

Genomic Location for HNRNPUL2-BSCL2 Gene

Chromosome:
11
Start:
62,690,262 bp from pter
End:
62,727,384 bp from pter
Size:
37,123 bases
Orientation:
Minus strand

Genomic View for HNRNPUL2-BSCL2 Gene

Genes around HNRNPUL2-BSCL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPUL2-BSCL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPUL2-BSCL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPUL2-BSCL2 Gene

Proteins for HNRNPUL2-BSCL2 Gene

  • Protein details for HNRNPUL2-BSCL2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BQZ7
    Recommended name:
    HCG2044799
    Protein Accession:
    H3BQZ7

    Protein attributes for HNRNPUL2-BSCL2 Gene

    Size:
    746 amino acids
    Molecular mass:
    84691 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HNRNPUL2-BSCL2 Gene

Post-translational modifications for HNRNPUL2-BSCL2 Gene

No Post-translational modifications

Other Protein References for HNRNPUL2-BSCL2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for HNRNPUL2-BSCL2 Gene

Domains & Families for HNRNPUL2-BSCL2 Gene

Protein Domains for HNRNPUL2-BSCL2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPUL2-BSCL2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HNRNPUL2-BSCL2 Gene

Function for HNRNPUL2-BSCL2 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HNRNPUL2-BSCL2 Gene

Localization for HNRNPUL2-BSCL2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HNRNPUL2-BSCL2 Gene

Pathways & Interactions for HNRNPUL2-BSCL2 Gene

SuperPathways for HNRNPUL2-BSCL2 Gene

No Data Available

Interacting Proteins for HNRNPUL2-BSCL2 Gene

Gene Ontology (GO) - Biological Process for HNRNPUL2-BSCL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HNRNPUL2-BSCL2 Gene

Drugs & Compounds for HNRNPUL2-BSCL2 Gene

No Compound Related Data Available

Transcripts for HNRNPUL2-BSCL2 Gene

mRNA/cDNA for HNRNPUL2-BSCL2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPUL2-BSCL2 Gene

No ASD Table

Relevant External Links for HNRNPUL2-BSCL2 Gene

GeneLoc Exon Structure for
HNRNPUL2-BSCL2
ECgene alternative splicing isoforms for
HNRNPUL2-BSCL2

Expression for HNRNPUL2-BSCL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPUL2-BSCL2 Gene

Evidence on tissue expression from TISSUES for HNRNPUL2-BSCL2 Gene

  • Heart(2.5)
genes like me logo Genes that share expression patterns with HNRNPUL2-BSCL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPUL2-BSCL2 Gene

Orthologs for HNRNPUL2-BSCL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPUL2-BSCL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HNRNPUL2 35
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Hnrnpul2 35
  • 92 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii HNRNPUL2 35
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30122 35
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y41E3.11 35
  • 8 (a)
OneToMany
Species where no ortholog for HNRNPUL2-BSCL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HNRNPUL2-BSCL2 Gene

ENSEMBL:
Gene Tree for HNRNPUL2-BSCL2 (if available)
TreeFam:
Gene Tree for HNRNPUL2-BSCL2 (if available)

Paralogs for HNRNPUL2-BSCL2 Gene

Paralogs for HNRNPUL2-BSCL2 Gene

(5) SIMAP similar genes for HNRNPUL2-BSCL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HNRNPUL2-BSCL2: view

Variants for HNRNPUL2-BSCL2 Gene

Sequence variations from dbSNP and Humsavar for HNRNPUL2-BSCL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1057517657 Pathogenic 62,705,371(-) TCTTC(C/T)TCTAT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1057517658 Pathogenic 62,705,357(-) TCCTT(-/TT)CTACT nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant
rs1057517659 Pathogenic 62,705,320(-) TCAGC(C/GGA)CTGTG nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant
rs1057517660 Pathogenic 62,692,475(-) CTCAC(A/G)GTACG splice-acceptor-variant
rs137852970 Pathogenic 62,694,594(-) GTGGC(C/T)GAATC nc-transcript-variant, reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for HNRNPUL2-BSCL2 Gene

Variant ID Type Subtype PubMed ID
nsv348 CNV deletion 18451855
nsv555174 CNV gain 21841781
nsv832182 CNV gain+loss 17160897

Relevant External Links for HNRNPUL2-BSCL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPUL2-BSCL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HNRNPUL2-BSCL2 Gene

Disorders for HNRNPUL2-BSCL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNRNPUL2-BSCL2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
berardinelli-seip congenital lipodystrophy
  • berardinelli-seip congenital generalized lipodystrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HNRNPUL2-BSCL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPUL2-BSCL2
genes like me logo Genes that share disorders with HNRNPUL2-BSCL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPUL2-BSCL2 Gene

Publications for HNRNPUL2-BSCL2 Gene

  1. Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. (PMID: 24554482) Leger P.D. … Haas D.W. (J. Neurovirol. 2014) 3 64
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64

Products for HNRNPUL2-BSCL2 Gene

Sources for HNRNPUL2-BSCL2 Gene

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