Aliases for HNRNPUL2-BSCL2 Gene
Subcategory (RNA class) for HNRNPUL2-BSCL2 Gene
ncRNA
Quality Score for this RNA gene is
3
External Ids for HNRNPUL2-BSCL2 Gene
- HGNC: 49189
- Entrez Gene: 100534595
- Ensembl: ENSG00000234857
Previous GeneCards Identifiers for HNRNPUL2-BSCL2 Gene
- GC11U901839
- GC11M062479
- GC11M062491
- GC11M062691
- GC11M062697
- GC11M062719
- GC11M062730
- GC11M062742
Summaries for HNRNPUL2-BSCL2 Gene
-
This locus represents naturally occurring read-through transcription between the neighboring HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U-like 2) and BSCL2 (Berardinelli-Seip congenital lipodystrophy 2 (seipin)) genes on chromosome 11. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Mar 2011]
GeneCards Summary for HNRNPUL2-BSCL2 Gene
HNRNPUL2-BSCL2 (HNRNPUL2-BSCL2 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. Diseases associated with HNRNPUL2-BSCL2 include Berardinelli-Seip Congenital Lipodystrophy. GO annotations related to this gene include nucleic acid binding and kinase activity. An important paralog of this gene is HNRNPUL2.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPUL2-BSCL2 Gene
Genomics for HNRNPUL2-BSCL2 Gene
Regulatory Elements for HNRNPUL2-BSCL2 Gene
Enhancers for HNRNPUL2-BSCL2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G062750 | 0.5 | ENCODE | 12 | -23.7 | -23726 | 0.4 | POLR2A PRDM10 ZNF384 | TTC9C HNRNPUL2 HNRNPUL2-BSCL2 TAF6L SLC3A2 SNHG1 SNORD22 AHNAK GANAB GC11M062774 |
| GH11G062724 | 1.4 | ENCODE dbSUPER | 0.7 | +0.2 | 215 | 6.2 | CREB3L1 MLX DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 | TTC9C IMMP1LP1 HNRNPUL2 EEF1G GANAB HNRNPUL2-BSCL2 PIR38618 |
| GH11G062722 | 0.7 | ENCODE | 0.4 | +5.2 | 5181 | 0.2 | CTCF SAP130 TEAD1 TEAD4 ARID4B SIN3A MNT RAD21 TEAD3 ZNF157 | HNRNPUL2-BSCL2 PIR38618 |
| GH11G062719 | 0.6 | ENCODE | 0.4 | +7.5 | 7493 | 1.7 | FOXA2 SMAD5 ZKSCAN8 MYNN TCF7 ZBTB33 | TTC9C HNRNPUL2-BSCL2 PIR38618 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HNRNPUL2-BSCL2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HNRNPUL2-BSCL2 Gene
- Chromosome:
- 11
- Start:
- 62,690,262 bp from pter
- End:
- 62,727,384 bp from pter
- Size:
- 37,123 bases
- Orientation:
- Minus strand
Genomic View for HNRNPUL2-BSCL2 Gene
Genes around HNRNPUL2-BSCL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.3 by Ensembl
- 11q12.3 by Entrez Gene
- 11q12.3 by HGNC
HNRNPUL2-BSCL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPUL2-BSCL2 Gene
Proteins for HNRNPUL2-BSCL2 Gene
-
Protein details for HNRNPUL2-BSCL2 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- H3BQZ7
- Recommended name:
- HCG2044799
- Protein Accession:
- H3BQZ7
Protein attributes for HNRNPUL2-BSCL2 Gene
- Size:
- 746 amino acids
- Molecular mass:
- 84691 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for HNRNPUL2-BSCL2 Gene
No Post-translational modifications
Other Protein References for HNRNPUL2-BSCL2 Gene
- ENSEMBL proteins:
Antibody Products
- Search GeneTex for Antibodies for HNRNPUL2-BSCL2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HNRNPUL2-BSCL2
- Origene Custom Protein Services for HNRNPUL2-BSCL2
- Search GeneTex for Proteins for HNRNPUL2-BSCL2
Assay Products
No data available for DME Specific Peptides for HNRNPUL2-BSCL2 Gene
Domains & Families for HNRNPUL2-BSCL2 Gene
Protein Domains for HNRNPUL2-BSCL2 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HNRNPUL2-BSCL2 Gene
Function for HNRNPUL2-BSCL2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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CRISPR Products
- Browse CRISPR knockouts for HNRNPUL2-BSCL2
miRNA Products
- Search ViGene Biosciences for HNRNPUL2-BSCL2
Inhibitory RNA Products
- Search ViGene Biosciences for HNRNPUL2-BSCL2
Cell Line Products
- Search ViGene Biosciences for HNRNPUL2-BSCL2
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HNRNPUL2-BSCL2 Gene
Localization for HNRNPUL2-BSCL2 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HNRNPUL2-BSCL2 Gene
Transcripts for HNRNPUL2-BSCL2 Gene
mRNA/cDNA for HNRNPUL2-BSCL2 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for HNRNPUL2-BSCL2
miRNA Products
- Search ViGene Biosciences for HNRNPUL2-BSCL2
Inhibitory RNA Products
- Search ViGene Biosciences for HNRNPUL2-BSCL2
Flow Cytometry Products
Relevant External Links for HNRNPUL2-BSCL2 Gene
- GeneLoc Exon Structure for
- HNRNPUL2-BSCL2
- ECgene alternative splicing isoforms for
- HNRNPUL2-BSCL2
Expression for HNRNPUL2-BSCL2 Gene
Evidence on tissue expression from TISSUES for HNRNPUL2-BSCL2 Gene
- Heart(2.5)
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPUL2-BSCL2 Gene
Orthologs for HNRNPUL2-BSCL2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | HNRNPUL2 35 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Hnrnpul2 35 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | HNRNPUL2 35 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG30122 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | Y41E3.11 35 |
|
OneToMany |
- Species where no ortholog for HNRNPUL2-BSCL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for HNRNPUL2-BSCL2 Gene
- ENSEMBL:
- Gene Tree for HNRNPUL2-BSCL2 (if available)
- TreeFam:
- Gene Tree for HNRNPUL2-BSCL2 (if available)
Paralogs for HNRNPUL2-BSCL2 Gene
Variants for HNRNPUL2-BSCL2 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1057517657 | Pathogenic | 62,705,371(-) | TCTTC(C/T)TCTAT | nc-transcript-variant, upstream-variant-2KB, reference, missense | |
| rs1057517658 | Pathogenic | 62,705,357(-) | TCCTT(-/TT)CTACT | nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant | |
| rs1057517659 | Pathogenic | 62,705,320(-) | TCAGC(C/GGA)CTGTG | nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant | |
| rs1057517660 | Pathogenic | 62,692,475(-) | CTCAC(A/G)GTACG | splice-acceptor-variant | |
| rs137852970 | Pathogenic | 62,694,594(-) | GTGGC(C/T)GAATC | nc-transcript-variant, reference, stop-gained |
Relevant External Links for HNRNPUL2-BSCL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HNRNPUL2-BSCL2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HNRNPUL2-BSCL2 Gene
Disorders for HNRNPUL2-BSCL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| berardinelli-seip congenital lipodystrophy |
|
|
Search HNRNPUL2-BSCL2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HNRNPUL2-BSCL2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HNRNPUL2-BSCL2
No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPUL2-BSCL2 Gene
Publications for HNRNPUL2-BSCL2 Gene
- Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. (PMID: 24554482) Leger P.D. … Haas D.W. (J. Neurovirol. 2014) 3 64
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64
Products for HNRNPUL2-BSCL2 Gene
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- Novus Biologicals
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HNRNPUL2-BSCL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
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- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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- (77) Proteopedia
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