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HNRNPUL2 Gene(Protein Coding)

Heterogeneous Nuclear Ribonucleoprotein U Like 2

GCID:
GC11M062712
GIFtS:
45
Genes Participants
UDN Logo

Aliases for HNRNPUL2 Gene

Aliases for HNRNPUL2 Gene

  • Heterogeneous Nuclear Ribonucleoprotein U Like 2 2 3 5
  • Scaffold-Attachment Factor A2 3 4
  • HNRPUL2 3 4
  • SAF-A2 3 4
  • Heterogeneous Nuclear Ribonucleoprotein U-Like Protein 2 3
  • Heterogeneous Nuclear Ribonucleoprotein U-Like 2 2

External Ids for HNRNPUL2 Gene

Previous HGNC Symbols for HNRNPUL2 Gene

  • HNRPUL2

Previous GeneCards Identifiers for HNRNPUL2 Gene

  • GC11M062236
  • GC11M062482
  • GC11M058810
  • GC11M062493

Summaries for HNRNPUL2 Gene

GeneCards Summary for HNRNPUL2 Gene

HNRNPUL2 (Heterogeneous Nuclear Ribonucleoprotein U Like 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and kinase activity. An important paralog of this gene is HNRNPUL2-BSCL2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPUL2 Gene

Genomics for HNRNPUL2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for HNRNPUL2 Gene

Enhancers for HNRNPUL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G062024 2.2 FANTOM5 Ensembl ENCODE dbSUPER 12.9 +701.8 701821 2.9 MLX CREB3L1 AGO1 DMAP1 YY1 ZNF143 SP3 TBX21 MEF2D NBN FTH1 TTC9C HNRNPUL2 EEF1G BEST1 DAGLA FEN1 RPS2P37 GC11P062053
GH11G062551 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13 +170.2 170209 12.9 CREB3L1 FEZF1 DMAP1 YBX1 ZNF143 SP3 NFYC TBX21 MEF2D SSRP1 EML3 TAF6L TTC9C HNRNPUL2 EEF1G ENSG00000255508 TUT1 MTA2 ENSG00000254964 LOC102723765
GH11G062012 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.9 +714.1 714142 2.2 PKNOX1 FOXA2 AGO1 FOS KLF13 CAVIN1 ZNF592 MEF2D CREB3 SMARCA4 TTC9C HNRNPUL2 AHNAK FTH1 DAGLA RPS2P37 GC11P062053
GH11G062054 1.5 Ensembl ENCODE dbSUPER 12.9 +672.8 672825 0.7 ATF1 ARID4B SIN3A FEZF1 BRCA1 ZNF2 TCF12 CBX5 REST PPARG INCENP TTC9C HNRNPUL2 BEST1 FTH1 RAB3IL1 FADS3 FADS1 GC11P062053 ENSG00000254424
GH11G062724 1.4 ENCODE dbSUPER 13.6 +0.2 216 6.2 CREB3L1 MLX DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 TTC9C IMMP1LP1 HNRNPUL2 EEF1G GANAB HNRNPUL2-BSCL2 PIR38618
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HNRNPUL2 on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPUL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040468 -15 4801 CREB3L1 MLX DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1

Transcription factor binding sites by QIAGEN in the HNRNPUL2 gene promoter:

Genomic Location for HNRNPUL2 Gene

Chromosome:
11
Start:
62,712,625 bp from pter
End:
62,727,385 bp from pter
Size:
14,761 bases
Orientation:
Minus strand

Genomic View for HNRNPUL2 Gene

Genes around HNRNPUL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPUL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPUL2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HNRNPUL2 Gene

Proteins for HNRNPUL2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HNRNPUL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1KMD3-HNRL2_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein U-like protein 2
    Protein Accession:
    Q1KMD3
    Secondary Accessions:
    • Q8N3B3

    Protein attributes for HNRNPUL2 Gene

    Size:
    747 amino acids
    Molecular mass:
    85105 Da
    Quaternary structure:
    • Binds to MLF1 and retains it in the nucleus.

neXtProt entry for HNRNPUL2 Gene

Protein Expression for HNRNPUL2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HNRNPUL2 Gene

  • Ubiquitination at isoforms=273, isoforms=406, posLast=471471, isoforms=553, and isoforms=601
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPUL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPUL2 Gene

Domains & Families for HNRNPUL2 Gene

Protein Domains for HNRNPUL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HNRNPUL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPUL2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Function for HNRNPUL2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Gene Ontology (GO) - Molecular Function for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HNRNPUL2: view

Phenotypes for HNRNPUL2 Gene

GenomeRNAi human phenotypes for HNRNPUL2:
genes like me logo Genes that share phenotypes with HNRNPUL2: view

Animal Model Products

CRISPR Products

miRNA for HNRNPUL2 Gene

miRTarBase miRNAs that target HNRNPUL2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPUL2 Gene

Localization for HNRNPUL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPUL2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HNRNPUL2: view

Pathways & Interactions for HNRNPUL2 Gene

SuperPathways for HNRNPUL2 Gene

PathCards logo More details on SuperPathways for HNRNPUL2
No Data Available

Gene Ontology (GO) - Biological Process for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HNRNPUL2: view

No data available for Pathways by source and SIGNOR curated interactions for HNRNPUL2 Gene

Drugs & Compounds for HNRNPUL2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for HNRNPUL2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HNRNPUL2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(779) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HNRNPUL2 Gene

Heterogeneous nuclear ribonucleoprotein U-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPUL2 Gene

No ASD Table

Relevant External Links for HNRNPUL2 Gene

GeneLoc Exon Structure for
HNRNPUL2
ECgene alternative splicing isoforms for
HNRNPUL2

Expression for HNRNPUL2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPUL2 Gene

mRNA expression in normal human tissues for HNRNPUL2 Gene
mRNA expression by BioGPS for HNRNPUL2 GenemRNA expression by GTEx for HNRNPUL2 Gene

Protein differential expression in normal tissues from HIPED for HNRNPUL2 Gene

This gene is overexpressed in Tlymphocyte (9.9), Peripheral blood mononuclear cells (7.1), and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPUL2 Gene



Protein tissue co-expression partners for HNRNPUL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPUL2 Gene:

HNRNPUL2

SOURCE GeneReport for Unigene cluster for HNRNPUL2 Gene:

Hs.657058

Evidence on tissue expression from TISSUES for HNRNPUL2 Gene

  • Heart(2.5)
  • Spleen(2.5)
  • Nervous system(2.5)
  • Kidney(2.3)
  • Intestine(2.2)
  • Lung(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with HNRNPUL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPUL2 Gene

Orthologs for HNRNPUL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPUL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HNRNPUL2 34 35
  • 99.64 (n)
dog
(Canis familiaris)
 Mammalia -- 35
  • 96 (a)
 OneToMany
HNRNPUL2 34
  • 94.96 (n)
cow
(Bos Taurus)
 Mammalia HNRNPUL2 34 35
  • 94.33 (n)
rat
(Rattus norvegicus)
 Mammalia Hnrnpul2 34
  • 92.26 (n)
mouse
(Mus musculus)
 Mammalia Hnrnpul2 34 16 35
  • 92.13 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 82 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 80 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 60 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia hnrnpul2 34
  • 61.47 (n)
Str.17711 34
African clawed frog
(Xenopus laevis)
 Amphibia Xl.11697 34
zebrafish
(Danio rerio)
 Actinopterygii HNRNPUL2 35
  • 35 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG30122 35
  • 17 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea Y41E3.11 35
  • 8 (a)
 OneToMany
Species where no ortholog for HNRNPUL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPUL2 Gene

ENSEMBL:
Gene Tree for HNRNPUL2 (if available)
TreeFam:
Gene Tree for HNRNPUL2 (if available)

Paralogs for HNRNPUL2 Gene

Paralogs for HNRNPUL2 Gene

(4) SIMAP similar genes for HNRNPUL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HNRNPUL2: view

Variants for HNRNPUL2 Gene

Sequence variations from dbSNP and Humsavar for HNRNPUL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000314782 -- 62,713,697(+) ATCAG(C/T)CCACA intron-variant, utr-variant-3-prime
rs1000387734 -- 62,716,705(+) AACTA(A/G)ATAGA intron-variant
rs1000417515 -- 62,716,363(+) CTGTC(A/G)GCATT intron-variant
rs1000457536 -- 62,719,624(+) ACCAG(A/G)GATAA intron-variant
rs1000707265 -- 62,727,479(+) CCTCC(C/T)GCCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HNRNPUL2 Gene

Variant ID Type Subtype PubMed ID
nsv348 CNV deletion 18451855
nsv555174 CNV gain 21841781

Variation tolerance for HNRNPUL2 Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPUL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPUL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Disorders for HNRNPUL2 Gene

Relevant External Links for HNRNPUL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPUL2

No disorders were found for HNRNPUL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPUL2 Gene

Publications for HNRNPUL2 Gene

  1. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3 64
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for HNRNPUL2 Gene

Sources for HNRNPUL2 Gene

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