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Aliases for HNRNPUL2 Gene

Aliases for HNRNPUL2 Gene

  • Heterogeneous Nuclear Ribonucleoprotein U Like 2 2 3 5
  • Scaffold-Attachment Factor A2 3 4
  • HNRPUL2 3 4
  • SAF-A2 3 4
  • Heterogeneous Nuclear Ribonucleoprotein U-Like Protein 2 3
  • Heterogeneous Nuclear Ribonucleoprotein U-Like 2 2

External Ids for HNRNPUL2 Gene

Previous HGNC Symbols for HNRNPUL2 Gene

  • HNRPUL2

Previous GeneCards Identifiers for HNRNPUL2 Gene

  • GC11M062236
  • GC11M062482
  • GC11M058810
  • GC11M062493

Summaries for HNRNPUL2 Gene

GeneCards Summary for HNRNPUL2 Gene

HNRNPUL2 (Heterogeneous Nuclear Ribonucleoprotein U Like 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and kinase activity. An important paralog of this gene is HNRNPUL2-BSCL2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPUL2 Gene

Genomics for HNRNPUL2 Gene

Regulatory Elements for HNRNPUL2 Gene

Enhancers for HNRNPUL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F062724 0.2 ENCODE 13.6 +0.2 216 6.2 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 TTC9C SCGB1D1 EEF1DP8 ENSG00000203520 IMMP1LP1 HNRNPUL2 EEF1G TAF6L LRRN4CL METTL12
GH11F062597 0.7 VISTA ENCODE 13 +126.8 126765 6.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A YBX1 DMAP1 ZNF2 SLC30A9 EML3 EEF1G TTC9C INTS5 LOC105369332 MIR6748 NXF1 HNRNPUL2 UBXN1 MTA2
GH11F062551 1.2 FANTOM5 Ensembl ENCODE 13 +170.2 170209 12.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 FEZF1 DMAP1 EML3 TTC9C TAF6L HNRNPUL2 EEF1G TUT1 MTA2 ENSG00000254964 LOC102723765 SCGB1A1
GH11F062054 1.1 Ensembl ENCODE 12.9 +672.9 672925 0.9 ATF1 ARNT ARID4B SIN3A FEZF1 BRCA1 ZNF2 CBX5 REST PPARG INCENP TTC9C HNRNPUL2 BEST1 FTH1 RAB3IL1 FADS3 FADS1 MIR1908 GC11P062053
GH11F062041 1.4 Ensembl ENCODE 12.9 +682.0 681958 8.1 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 SP3 NFYC MEF2D METTL12 INTS5 SNHG1 NXF1 TMEM138 LOC105369332 VPS37C EML3 MTA2 TAF6L
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HNRNPUL2 on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPUL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001570677 185 5601 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1

Genomic Location for HNRNPUL2 Gene

Chromosome:
11
Start:
62,712,625 bp from pter
End:
62,727,385 bp from pter
Size:
14,761 bases
Orientation:
Minus strand

Genomic View for HNRNPUL2 Gene

Genes around HNRNPUL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPUL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPUL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPUL2 Gene

Proteins for HNRNPUL2 Gene

  • Protein details for HNRNPUL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1KMD3-HNRL2_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein U-like protein 2
    Protein Accession:
    Q1KMD3
    Secondary Accessions:
    • Q8N3B3

    Protein attributes for HNRNPUL2 Gene

    Size:
    747 amino acids
    Molecular mass:
    85105 Da
    Quaternary structure:
    • Binds to MLF1 and retains it in the nucleus.

neXtProt entry for HNRNPUL2 Gene

Post-translational modifications for HNRNPUL2 Gene

  • Ubiquitination at Lys 273, Lys 406, Lys 471, Lys 553, and Lys 601
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPUL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPUL2 Gene

Domains & Families for HNRNPUL2 Gene

Protein Domains for HNRNPUL2 Gene

Suggested Antigen Peptide Sequences for HNRNPUL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1KMD3

UniProtKB/Swiss-Prot:

HNRL2_HUMAN :
  • Contains 1 B30.2/SPRY domain.
Domain:
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 SAP domain.
genes like me logo Genes that share domains with HNRNPUL2: view

No data available for Gene Families for HNRNPUL2 Gene

Function for HNRNPUL2 Gene

Gene Ontology (GO) - Molecular Function for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HNRNPUL2: view

Phenotypes for HNRNPUL2 Gene

genes like me logo Genes that share phenotypes with HNRNPUL2: view

Animal Model Products

miRNA for HNRNPUL2 Gene

miRTarBase miRNAs that target HNRNPUL2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPUL2 Gene

Localization for HNRNPUL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPUL2 Gene COMPARTMENTS Subcellular localization image for HNRNPUL2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HNRNPUL2: view

Pathways & Interactions for HNRNPUL2 Gene

SuperPathways for HNRNPUL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HNRNPUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HNRNPUL2: view

No data available for Pathways by source and SIGNOR curated interactions for HNRNPUL2 Gene

Transcripts for HNRNPUL2 Gene

mRNA/cDNA for HNRNPUL2 Gene

Unigene Clusters for HNRNPUL2 Gene

Heterogeneous nuclear ribonucleoprotein U-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPUL2 Gene

No ASD Table

Relevant External Links for HNRNPUL2 Gene

GeneLoc Exon Structure for
HNRNPUL2
ECgene alternative splicing isoforms for
HNRNPUL2

Expression for HNRNPUL2 Gene

mRNA expression in normal human tissues for HNRNPUL2 Gene

Protein differential expression in normal tissues from HIPED for HNRNPUL2 Gene

This gene is overexpressed in Tlymphocyte (9.9), Peripheral blood mononuclear cells (7.1), and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPUL2 Gene



Protein tissue co-expression partners for HNRNPUL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPUL2 Gene:

HNRNPUL2

SOURCE GeneReport for Unigene cluster for HNRNPUL2 Gene:

Hs.657058
genes like me logo Genes that share expression patterns with HNRNPUL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPUL2 Gene

Orthologs for HNRNPUL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPUL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPUL2 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 96 (a)
OneToMany
HNRNPUL2 34
  • 94.96 (n)
cow
(Bos Taurus)
Mammalia HNRNPUL2 34 35
  • 94.33 (n)
rat
(Rattus norvegicus)
Mammalia Hnrnpul2 34
  • 92.26 (n)
mouse
(Mus musculus)
Mammalia Hnrnpul2 34 16 35
  • 92.13 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 60 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpul2 34
  • 61.47 (n)
Str.17711 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11697 34
zebrafish
(Danio rerio)
Actinopterygii HNRNPUL2 35
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30122 35
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y41E3.11 35
  • 8 (a)
OneToMany
Species where no ortholog for HNRNPUL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPUL2 Gene

ENSEMBL:
Gene Tree for HNRNPUL2 (if available)
TreeFam:
Gene Tree for HNRNPUL2 (if available)

Paralogs for HNRNPUL2 Gene

Paralogs for HNRNPUL2 Gene

(4) SIMAP similar genes for HNRNPUL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HNRNPUL2: view

Variants for HNRNPUL2 Gene

Sequence variations from dbSNP and Humsavar for HNRNPUL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1046323 -- 62,712,844(-) AAAAC(A/C)CCACA intron-variant, utr-variant-3-prime
rs10615770 -- 62,720,864(+) GTCTC(-/A)AAAAA intron-variant
rs10897291 -- 62,720,646(+) gatca(A/T)gaggt intron-variant
rs111380010 -- 62,712,753(+) TTACA(-/T)TTTTT intron-variant, utr-variant-3-prime
rs111417415 -- 62,724,428(+) TCTCC(C/T)ACAAA splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPUL2 Gene

Variant ID Type Subtype PubMed ID
nsv348 CNV deletion 18451855
nsv555174 CNV gain 21841781

Variation tolerance for HNRNPUL2 Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPUL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPUL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPUL2 Gene

Disorders for HNRNPUL2 Gene

Relevant External Links for HNRNPUL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPUL2

No disorders were found for HNRNPUL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPUL2 Gene

Publications for HNRNPUL2 Gene

  1. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3 64
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for HNRNPUL2 Gene

Sources for HNRNPUL2 Gene

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