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Aliases for HNRNPUL1 Gene

Aliases for HNRNPUL1 Gene

  • Heterogeneous Nuclear Ribonucleoprotein U Like 1 2 3
  • Heterogeneous Nuclear Ribonucleoprotein U-Like 1 3 5
  • Adenovirus Early Region 1B-Associated Protein 5 3 4
  • E1B-55 KDa-Associated Protein 5 3 4
  • E1B 55kDa Associated Protein 5 2 3
  • HNRPUL1 3 4
  • E1B-AP5 3 4
  • E1BAP5 3 4

External Ids for HNRNPUL1 Gene

Previous HGNC Symbols for HNRNPUL1 Gene

  • HNRPUL1

Previous GeneCards Identifiers for HNRNPUL1 Gene

  • GC19P046463
  • GC19P041768
  • GC19P038200

Summaries for HNRNPUL1 Gene

Entrez Gene Summary for HNRNPUL1 Gene

  • This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]

GeneCards Summary for HNRNPUL1 Gene

HNRNPUL1 (Heterogeneous Nuclear Ribonucleoprotein U Like 1) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPUL2-BSCL2.

UniProtKB/Swiss-Prot for HNRNPUL1 Gene

  • Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.

Gene Wiki entry for HNRNPUL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPUL1 Gene

Genomics for HNRNPUL1 Gene

Regulatory Elements for HNRNPUL1 Gene

Promoters for HNRNPUL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HNRNPUL1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HNRNPUL1 gene promoter:

Genomic Location for HNRNPUL1 Gene

Chromosome:
19
Start:
41,262,476 bp from pter
End:
41,307,693 bp from pter
Size:
45,218 bases
Orientation:
Plus strand

Genomic View for HNRNPUL1 Gene

Genes around HNRNPUL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPUL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPUL1 Gene

Proteins for HNRNPUL1 Gene

  • Protein details for HNRNPUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUJ2-HNRL1_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein U-like protein 1
    Protein Accession:
    Q9BUJ2
    Secondary Accessions:
    • B3KMW7
    • O76022
    • Q6ZSZ0
    • Q7L8P4
    • Q8N6Z4
    • Q96G37
    • Q9HAL3
    • Q9UG75

    Protein attributes for HNRNPUL1 Gene

    Size:
    856 amino acids
    Molecular mass:
    95739 Da
    Quaternary structure:
    • Interacts with the adenovirus type 5 (Ad5) E1B-55 kDa, BRD7, PRMT2, TP53 and NXF1. Associates with histones and BRD7.
    Miscellaneous:
    • Its methylation is enhanced in the late phase of adenoviral infection.

    Alternative splice isoforms for HNRNPUL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPUL1 Gene

Proteomics data for HNRNPUL1 Gene at MOPED

Post-translational modifications for HNRNPUL1 Gene

No data available for DME Specific Peptides for HNRNPUL1 Gene

Domains & Families for HNRNPUL1 Gene

Protein Domains for HNRNPUL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BUJ2

UniProtKB/Swiss-Prot:

HNRL1_HUMAN :
  • The RGG-box domain is methylated.
Domain:
  • The RGG-box domain is methylated.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 SAP domain.
genes like me logo Genes that share domains with HNRNPUL1: view

No data available for Gene Families for HNRNPUL1 Gene

Function for HNRNPUL1 Gene

Molecular function for HNRNPUL1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.
genes like me logo Genes that share phenotypes with HNRNPUL1: view

Animal Model Products

miRNA for HNRNPUL1 Gene

miRTarBase miRNAs that target HNRNPUL1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPUL1 Gene

Localization for HNRNPUL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPUL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPUL1 Gene COMPARTMENTS Subcellular localization image for HNRNPUL1 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for HNRNPUL1 Gene

Pathways & Interactions for HNRNPUL1 Gene

genes like me logo Genes that share pathways with HNRNPUL1: view

Pathways by source for HNRNPUL1 Gene

1 KEGG pathway for HNRNPUL1 Gene

Gene Ontology (GO) - Biological Process for HNRNPUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HNRNPUL1: view

No data available for SIGNOR curated interactions for HNRNPUL1 Gene

Drugs & Compounds for HNRNPUL1 Gene

No Compound Related Data Available

Transcripts for HNRNPUL1 Gene

Unigene Clusters for HNRNPUL1 Gene

Heterogeneous nuclear ribonucleoprotein U-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPUL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b ^
SP1: - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:
SP8: - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7: -
SP8:
SP9: -
SP10: -
SP11: -
SP12:
SP13:
SP14:

Relevant External Links for HNRNPUL1 Gene

GeneLoc Exon Structure for
HNRNPUL1
ECgene alternative splicing isoforms for
HNRNPUL1

Expression for HNRNPUL1 Gene

mRNA expression in normal human tissues for HNRNPUL1 Gene

Protein differential expression in normal tissues from HIPED for HNRNPUL1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.9) and Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPUL1 Gene



SOURCE GeneReport for Unigene cluster for HNRNPUL1 Gene Hs.155218

genes like me logo Genes that share expression patterns with HNRNPUL1: view

Protein tissue co-expression partners for HNRNPUL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPUL1 Gene

Orthologs for HNRNPUL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPUL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPUL1 36
  • 100 (a)
OneToOne
HNRNPUL1 35
  • 99.84 (n)
  • 99.88 (a)
cow
(Bos Taurus)
Mammalia HNRNPUL1 36
  • 98 (a)
OneToOne
HNRNPUL1 35
  • 92.45 (n)
  • 96.61 (a)
dog
(Canis familiaris)
Mammalia HNRNPUL1 36
  • 98 (a)
OneToOne
HNRNPUL1 35
  • 93.85 (n)
  • 98.48 (a)
mouse
(Mus musculus)
Mammalia Hnrnpul1 16
Hnrnpul1 36
  • 90 (a)
OneToOne
Hnrnpul1 35
  • 90.89 (n)
  • 95.91 (a)
oppossum
(Monodelphis domestica)
Mammalia HNRNPUL1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPUL1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnpul1 35
  • 90.78 (n)
  • 96.24 (a)
chicken
(Gallus gallus)
Aves HNRNPUL1 36
  • 68 (a)
OneToOne
HNRNPUL1 35
  • 72.91 (n)
  • 78.22 (a)
lizard
(Anolis carolinensis)
Reptilia HNRNPUL1 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wufb53d10 35
LOC100330645 35
  • 67.76 (n)
  • 68.58 (a)
hnrnpul1 36
  • 55 (a)
OneToMany
FP085405.1 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30122 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y41E3.11 36
  • 10 (a)
OneToMany
Species with no ortholog for HNRNPUL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HNRNPUL1 Gene

ENSEMBL:
Gene Tree for HNRNPUL1 (if available)
TreeFam:
Gene Tree for HNRNPUL1 (if available)

Paralogs for HNRNPUL1 Gene

Paralogs for HNRNPUL1 Gene

genes like me logo Genes that share paralogs with HNRNPUL1: view

Variants for HNRNPUL1 Gene

Sequence variations from dbSNP and Humsavar for HNRNPUL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1968453 -- 41,278,142(-) GGAGA(C/T)GTTGC intron-variant
rs3816052 -- 41,267,892(-) ATACA(C/T)AGGTA intron-variant
rs7245398 -- 41,304,739(+) TTCCC(A/G)TTCTT intron-variant
rs7256416 -- 41,282,026(+) TACCA(C/T)TTAAT intron-variant
rs7248164 -- 41,301,795(+) CCCCA(A/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPUL1 Gene

Variant ID Type Subtype PubMed ID
esv26941 CNV Gain 19812545
nsv911769 CNV Loss 21882294

Variation tolerance for HNRNPUL1 Gene

Residual Variation Intolerance Score: 5.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPUL1 Gene

HapMap Linkage Disequilibrium report
HNRNPUL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPUL1 Gene

Disorders for HNRNPUL1 Gene

Relevant External Links for HNRNPUL1

Genetic Association Database (GAD)
HNRNPUL1
Human Genome Epidemiology (HuGE) Navigator
HNRNPUL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPUL1

No disorders were found for HNRNPUL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPUL1 Gene

Publications for HNRNPUL1 Gene

  1. E1B-55kilodalton-associated protein: a cellular protein with RNA- binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs. (PMID: 9733834) Gabler S. … Dobner T. (J. Virol. 1998) 2 3 4 23 67
  2. The role of hnRPUL1 involved in DNA damage response is related to PARP1. (PMID: 23577092) Hong Z. … Yasui A. (PLoS ONE 2013) 2 3
  3. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. (PMID: 18599554) van der Net J.B. … Sijbrands E.J. (Eur. Heart J. 2008) 3 23
  4. Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. (PMID: 12489984) Kzhyshkowska J.G. … Dobner T. (Biochem. J. 2003) 2 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for HNRNPUL1 Gene

Sources for HNRNPUL1 Gene

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