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Aliases for HNRNPUL1 Gene

Aliases for HNRNPUL1 Gene

  • Heterogeneous Nuclear Ribonucleoprotein U Like 1 2 3 5
  • Adenovirus Early Region 1B-Associated Protein 5 3 4
  • E1B-55 KDa-Associated Protein 5 3 4
  • E1B 55kDa Associated Protein 5 2 3
  • HNRPUL1 3 4
  • E1B-AP5 3 4
  • E1BAP5 3 4
  • Heterogeneous Nuclear Ribonucleoprotein U-Like Protein 1 3

External Ids for HNRNPUL1 Gene

Previous HGNC Symbols for HNRNPUL1 Gene

  • HNRPUL1

Previous GeneCards Identifiers for HNRNPUL1 Gene

  • GC19P046463
  • GC19P041768
  • GC19P038200

Summaries for HNRNPUL1 Gene

Entrez Gene Summary for HNRNPUL1 Gene

  • This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]

GeneCards Summary for HNRNPUL1 Gene

HNRNPUL1 (Heterogeneous Nuclear Ribonucleoprotein U Like 1) is a Protein Coding gene. Among its related pathways are Influenza A and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPU.

UniProtKB/Swiss-Prot for HNRNPUL1 Gene

  • Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.

Gene Wiki entry for HNRNPUL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPUL1 Gene

Genomics for HNRNPUL1 Gene

Regulatory Elements for HNRNPUL1 Gene

Enhancers for HNRNPUL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F041294 1.6 FANTOM5 Ensembl ENCODE 18 +40.8 40821 16.8 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF526 SNRPA ENSG00000269843 ZNF574 CCDC97 ITPKC TGFB1 SERTAD3 TMEM91 ENSG00000268366
GH19F040796 1 FANTOM5 Ensembl ENCODE 14.2 -460.1 -460139 11.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF416 ZNF143 ZNF548 SNRPA ENSG00000269843 ENSG00000205041 ENSG00000269069 FBL ITPKC CCDC97 COQ8B NUMBL ENSG00000268366
GH19F041321 1.5 FANTOM5 ENCODE 7.4 +62.8 62826 8.4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 SLC30A9 ZNF143 FOS SP3 TGFB1 CIC NUMBL COQ8B SERTAD1 BLVRB HNRNPUL1 B9D2 CEACAM4 CCDC97
GH19F041343 0.3 FANTOM5 3.7 +81.4 81404 0.2 ZNF623 B9D2 HNRNPUL1 TGFB1 CCDC97 ENSG00000255730
GH19F041288 0.9 FANTOM5 ENCODE 3.5 +26.8 26816 0.9 CTCF ZFP64 RAD21 ZFHX2 ZNF143 PRDM10 ZBTB20 EGR2 ZNF654 YY2 CYP2A13 HNRNPUL1 B9D2 RN7SL34P LOC105372401
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HNRNPUL1 on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPUL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001014937 1624 5001 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D SSRP1

Transcription factor binding sites by QIAGEN in the HNRNPUL1 gene promoter:

Genomic Location for HNRNPUL1 Gene

Chromosome:
19
Start:
41,262,476 bp from pter
End:
41,307,693 bp from pter
Size:
45,218 bases
Orientation:
Plus strand

Genomic View for HNRNPUL1 Gene

Genes around HNRNPUL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPUL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPUL1 Gene

Proteins for HNRNPUL1 Gene

  • Protein details for HNRNPUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUJ2-HNRL1_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein U-like protein 1
    Protein Accession:
    Q9BUJ2
    Secondary Accessions:
    • B3KMW7
    • O76022
    • Q6ZSZ0
    • Q7L8P4
    • Q8N6Z4
    • Q96G37
    • Q9HAL3
    • Q9UG75

    Protein attributes for HNRNPUL1 Gene

    Size:
    856 amino acids
    Molecular mass:
    95739 Da
    Quaternary structure:
    • Interacts with the adenovirus type 5 (Ad5) E1B-55 kDa, BRD7, PRMT2, TP53 and NXF1. Associates with histones and BRD7.
    Miscellaneous:
    • Its methylation is enhanced in the late phase of adenoviral infection.

    Alternative splice isoforms for HNRNPUL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPUL1 Gene

Post-translational modifications for HNRNPUL1 Gene

No data available for DME Specific Peptides for HNRNPUL1 Gene

Domains & Families for HNRNPUL1 Gene

Protein Domains for HNRNPUL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BUJ2

UniProtKB/Swiss-Prot:

HNRL1_HUMAN :
  • The RGG-box domain is methylated.
Domain:
  • The RGG-box domain is methylated.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 SAP domain.
genes like me logo Genes that share domains with HNRNPUL1: view

No data available for Gene Families for HNRNPUL1 Gene

Function for HNRNPUL1 Gene

Molecular function for HNRNPUL1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.

Gene Ontology (GO) - Molecular Function for HNRNPUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9733834
GO:0005515 protein binding IPI 12489984
GO:0019899 enzyme binding IPI 11513728
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HNRNPUL1: view
genes like me logo Genes that share phenotypes with HNRNPUL1: view

Animal Model Products

miRNA for HNRNPUL1 Gene

miRTarBase miRNAs that target HNRNPUL1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPUL1 Gene

Localization for HNRNPUL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPUL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPUL1 Gene COMPARTMENTS Subcellular localization image for HNRNPUL1 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for HNRNPUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 11513728
GO:0005654 nucleoplasm IDA,TAS --
GO:0019013 viral nucleocapsid IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with HNRNPUL1: view

Pathways & Interactions for HNRNPUL1 Gene

genes like me logo Genes that share pathways with HNRNPUL1: view

Pathways by source for HNRNPUL1 Gene

1 KEGG pathway for HNRNPUL1 Gene

Gene Ontology (GO) - Biological Process for HNRNPUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006396 RNA processing IEA,TAS 9733834
GO:0009615 response to virus IEA --
genes like me logo Genes that share ontologies with HNRNPUL1: view

No data available for SIGNOR curated interactions for HNRNPUL1 Gene

Transcripts for HNRNPUL1 Gene

Unigene Clusters for HNRNPUL1 Gene

Heterogeneous nuclear ribonucleoprotein U-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPUL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b ^
SP1: - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:
SP8: - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7: -
SP8:
SP9: -
SP10: -
SP11: -
SP12:
SP13:
SP14:

Relevant External Links for HNRNPUL1 Gene

GeneLoc Exon Structure for
HNRNPUL1
ECgene alternative splicing isoforms for
HNRNPUL1

Expression for HNRNPUL1 Gene

mRNA expression in normal human tissues for HNRNPUL1 Gene

Protein differential expression in normal tissues from HIPED for HNRNPUL1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.9) and Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPUL1 Gene



Protein tissue co-expression partners for HNRNPUL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPUL1 Gene:

HNRNPUL1

SOURCE GeneReport for Unigene cluster for HNRNPUL1 Gene:

Hs.155218
genes like me logo Genes that share expression patterns with HNRNPUL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPUL1 Gene

Orthologs for HNRNPUL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPUL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPUL1 34 35
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia HNRNPUL1 34 35
  • 93.85 (n)
cow
(Bos Taurus)
Mammalia HNRNPUL1 34 35
  • 92.45 (n)
mouse
(Mus musculus)
Mammalia Hnrnpul1 34 16 35
  • 90.89 (n)
rat
(Rattus norvegicus)
Mammalia Hnrnpul1 34
  • 90.78 (n)
oppossum
(Monodelphis domestica)
Mammalia HNRNPUL1 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPUL1 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPUL1 34 35
  • 72.91 (n)
lizard
(Anolis carolinensis)
Reptilia HNRNPUL1 35
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100330645 34
  • 67.76 (n)
FP085405.1 35
  • 55 (a)
OneToMany
hnrnpul1 35
  • 55 (a)
OneToMany
wufb53d10 34
fruit fly
(Drosophila melanogaster)
Insecta CG30122 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y41E3.11 35
  • 10 (a)
OneToMany
Species where no ortholog for HNRNPUL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HNRNPUL1 Gene

ENSEMBL:
Gene Tree for HNRNPUL1 (if available)
TreeFam:
Gene Tree for HNRNPUL1 (if available)

Paralogs for HNRNPUL1 Gene

Paralogs for HNRNPUL1 Gene

genes like me logo Genes that share paralogs with HNRNPUL1: view

Variants for HNRNPUL1 Gene

Sequence variations from dbSNP and Humsavar for HNRNPUL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401902 -- 41,276,103(+) cgtct(C/G)aagaa intron-variant
rs10402476 -- 41,283,607(+) cacgc(C/T)accat intron-variant
rs10409636 -- 41,277,194(+) GGGAA(C/G)TTCTG intron-variant
rs10410836 -- 41,268,586(+) GGGTG(C/T)GGTGG intron-variant
rs10411097 -- 41,293,633(+) TACCC(A/C/G)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPUL1 Gene

Variant ID Type Subtype PubMed ID
esv26941 CNV gain 19812545
esv3644375 CNV loss 21293372
esv3644376 CNV loss 21293372

Variation tolerance for HNRNPUL1 Gene

Residual Variation Intolerance Score: 5.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPUL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPUL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPUL1 Gene

Disorders for HNRNPUL1 Gene

Relevant External Links for HNRNPUL1

Genetic Association Database (GAD)
HNRNPUL1
Human Genome Epidemiology (HuGE) Navigator
HNRNPUL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPUL1

No disorders were found for HNRNPUL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPUL1 Gene

Publications for HNRNPUL1 Gene

  1. E1B-55kilodalton-associated protein: a cellular protein with RNA- binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs. (PMID: 9733834) Gabler S. … Dobner T. (J. Virol. 1998) 2 3 4 22 64
  2. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. (PMID: 18599554) van der Net J.B. … Sijbrands E.J. (Eur. Heart J. 2008) 3 22 46 64
  3. Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. (PMID: 12489984) Kzhyshkowska J.G. … Dobner T. (Biochem. J. 2003) 2 3 4 64
  4. The role of hnRPUL1 involved in DNA damage response is related to PARP1. (PMID: 23577092) Hong Z. … Yasui A. (PLoS ONE 2013) 2 3 64
  5. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. (PMID: 19056482) Yoshida T. … Yamada Y. (Genomics 2009) 3 46 64

Products for HNRNPUL1 Gene

Sources for HNRNPUL1 Gene

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