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HNRNPUL1 Gene

protein-coding   GIFtS: 56
GCID: GC19P041768

Heterogeneous Nuclear Ribonucleoprotein U-Like 1


(Previous symbol: HNRPUL1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein U-Like 11 2     E1B-AP52 3
HNRPUL11 2 3 5     E1B-55 KDa-Associated Protein 52 3
E1BAP52 3 5     E1B-55kDa-Associated Protein 52
E1B 55kDa Associated Protein 51 2     Heterogeneous Nuclear Ribonucleoprotein U-Like Protein 12
Adenovirus Early Region 1B-Associated Protein 52 3     

External Ids:    HGNC: 170111   Entrez Gene: 111002   Ensembl: ENSG000001053237   OMIM: 6058005   UniProtKB: Q9BUJ23   

Export aliases for HNRNPUL1 gene to outside databases

Previous GC identifers: GC19P046463 GC19P038200


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPUL1 Gene:
This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family.
This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in
nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. Two
transcript variants encoding different isoforms have been found for this gene. Additional variants have also been
found, but their full-length natures have not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for HNRNPUL1 Gene:
HNRNPUL1 (heterogeneous nuclear ribonucleoprotein U-like 1) is a protein-coding gene. GO annotations related to this gene include RNA binding and enzyme binding. An important paralog of this gene is HNRNPUL2.

UniProtKB/Swiss-Prot: HNRL1_HUMAN, Q9BUJ2
Function: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and
cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in
the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G)
and poly(C) RNA homopolymers in vitro

Gene Wiki entry for HNRNPUL1 (HNRPUL1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPUL1 gene promoter:
         p53   NRSF form 1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HNRNPUL1 promoter sequence
   Search Chromatin IP Primers for HNRNPUL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPUL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

HNRNPUL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPUL1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041768:  view genomic region     (about GC identifiers)

Start:
41,768,391 bp from pter      End:
41,813,811 bp from pter
Size:
45,421 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HNRL1_HUMAN, Q9BUJ2 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein U-like protein 1  
Size: 856 amino acids; 95739 Da
Subunit: Interacts with the adenovirus type 5 (Ad5) E1B-55 kDa, BRD7, PRMT2, TP53 and NXF1. Associates with
histones and BRD7
Miscellaneous: Its methylation is enhanced in the late phase of adenoviral infection
Secondary accessions: B3KMW7 O76022 Q6ZSZ0 Q7L8P4 Q8N6Z4 Q96G37 Q9HAL3 Q9UG75
Alternative splicing: 5 isoforms:  Q9BUJ2-1   Q9BUJ2-2   Q9BUJ2-3   Q9BUJ2-4   Q9BUJ2-5   (May be due to intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HNRNPUL1: NX_Q9BUJ2

Explore proteomics data for HNRNPUL1 at MOPED

Post-translational modifications: 

  • Methylated1
  • Ubiquitination2 at Lys117, Lys146, Lys270, Lys440, Lys517, Lys527
  • Modification sites at PhosphoSitePlus

  • See HNRNPUL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_008971.2  NP_653333.1  

    ENSEMBL proteins: 
     ENSP00000340857   ENSP00000473132   ENSP00000469858   ENSP00000470172   ENSP00000470793  
     ENSP00000375863   ENSP00000367460   ENSP00000472315   ENSP00000470687   ENSP00000471302  
     ENSP00000472629   ENSP00000263367   ENSP00000472221   ENSP00000473178   ENSP00000469934  
     ENSP00000469816  
    Reactome Protein details: Q9BUJ2

    HNRNPUL1 Human Recombinant Protein Products:

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    Novus Biologicals HNRNPUL1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HNRNPUL1 

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    LSBio Antibodies in human, mouse, rat for HNRNPUL1

    HNRNPUL1 Assay Products:

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    Search eBioscience for ELISAs for HNRNPUL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR001870 B30.2/SPRY
     IPR027417 P-loop_NTPase
     IPR003877 SPRY_rcpt
     IPR003034 SAP_dom
     IPR018355 SPla/RYanodine_receptor_subgr

    Graphical View of Domain Structure for InterPro Entry Q9BUJ2

    ProtoNet protein and cluster: Q9BUJ2

    1 Blocks protein domain: IPB003034 DNA-binding SAP

    UniProtKB/Swiss-Prot: HNRL1_HUMAN, Q9BUJ2
    Domain: The RGG-box domain is methylated
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 SAP domain


    Find genes that share domains with HNRNPUL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRL1_HUMAN, Q9BUJ2
    Function: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and
    cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in
    the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G)
    and poly(C) RNA homopolymers in vitro

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS9733834
    GO:0005515protein binding IPI12489984
    GO:0019899enzyme binding IPI11513728
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with HNRNPUL1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HNRNPUL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HNRNPUL1
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    miRNA
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    miRTarBase miRNAs that target HNRNPUL1:
    hsa-mir-106b-3p (MIRT038557), hsa-mir-320b (MIRT036234), hsa-let-7f-5p (MIRT051364), hsa-mir-130b-3p (MIRT020111), hsa-mir-320a (MIRT044477), hsa-mir-23b-3p (MIRT046302), hsa-mir-151a-3p (MIRT043609), hsa-mir-671-5p (MIRT039298), hsa-mir-23a-3p (MIRT050412), hsa-let-7b-5p (MIRT052204), hsa-mir-18a-3p (MIRT040963), hsa-mir-423-3p (MIRT042513), hsa-mir-423-5p (MIRT038127), hsa-mir-93-3p (MIRT038812), hsa-let-7a-5p (MIRT052475), hsa-let-7e-5p (MIRT051648), hsa-mir-193b-3p (MIRT041455), hsa-mir-34a-5p (MIRT025310), hsa-mir-1229-3p (MIRT036352), hsa-mir-877-5p (MIRT037253), hsa-mir-191-5p (MIRT045815)

    Block miRNA regulation of human, mouse, rat HNRNPUL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPUL1 (see all 56):
    hsa-miR-100* hsa-miR-302d hsa-miR-520e hsa-miR-4272 hsa-miR-411 hsa-miR-29a hsa-miR-519a hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPUL1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): HNRNPUL1 (NM_144732)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPUL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPUL1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPUL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HNRL1_HUMAN, Q9BUJ2: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0019013viral nucleocapsid ----
    GO:0030529ribonucleoprotein complex IEA--

    Find genes that share ontologies with HNRNPUL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPUL1 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    2Gene Expression
    Gene Expression0.40
    3Influenza A
    Influenza A0.34


    Find genes that share SuperPaths with HNRNPUL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for HNRNPUL1
        mRNA Splicing - Major Pathway


    1 Kegg Pathway  (Kegg details for HNRNPUL1):
        Influenza A

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPUL1
    Interactions:

        Search GeneGlobe Interaction Network for HNRNPUL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPUL1 (Q9BUJ21, 2, 3 ENSP000003758634) via UniProtKB, MINT, STRING, and/or I2D (see all 308)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-58674 MINT-58678 MINT-58676 MINT-58675 MINT-8415355 MINT-58677 MINT-58672 MINT-58673 I2D: score=3 STRING: ENSP00000269305
    NXF1Q9UBU92, 3, ENSP000002941724MINT-17522 MINT-17521 I2D: score=3 STRING: ENSP00000294172
    PRPF40AO754002, 3MINT-65536 MINT-61863 I2D: score=6 
    MARSP561922, 3, ENSP000002620274MINT-63902 I2D: score=4 STRING: ENSP00000262027
    RAE1P784062, 3, ENSP000003602864MINT-7294504 I2D: score=1 STRING: ENSP00000360286
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006396RNA processing TAS9733834
    GO:0008380RNA splicing TAS--

    Find genes that share ontologies with HNRNPUL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPUL1 (HNRL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HNRNPUL1 gene (4 alternative transcripts): 
    NM_007040.3  NM_144732.2  NM_144733.1  NM_144734.1  

    Unigene Cluster for HNRNPUL1:

    Heterogeneous nuclear ribonucleoprotein U-like 1
    Hs.155218  [show with all ESTs]
    Unigene Representative Sequence: NM_007040
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000352456(uc002opz.4 uc002oqa.4 uc010xvy.2 uc010ehp.3)
    ENST00000595018 ENST00000597725 ENST00000599719 ENST00000601309 ENST00000392006(uc002oqb.4 uc010ehm.3 uc002oqc.4 uc002oqe.4 uc002oqd.4 uc010ehn.3)
    ENST00000378215(uc002oqf.4) ENST00000595196 ENST00000602130 ENST00000601336
    ENST00000593587 ENST00000594207 ENST00000263367(uc010ehl.1) ENST00000595336
    ENST00000599521 ENST00000599614 ENST00000600596 ENST00000600332
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HNRNPUL1 (see all 56):
    hsa-miR-100* hsa-miR-302d hsa-miR-520e hsa-miR-4272 hsa-miR-411 hsa-miR-29a hsa-miR-519a hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPUL1 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HNRNPUL1 (NM_144732)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPUL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPUL1
    Primer
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    OriGene qPCR primer pairs and template standards for HNRNPUL1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HNRNPUL1
      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPUL1
      QuantiFast Probe-based Assays in human, mouse, rat HNRNPUL1

    Additional mRNA sequence: 

    AJ007509.1 AK001229.1 AK021455.1 AK022863.1 AK023006.1 AK127057.1 AK225850.1 AK290729.1 
    AK291315.1 AK291762.1 AK297127.1 AK308078.1 AK308156.1 AL050146.1 BC000860.1 BC002564.2 
    BC004242.1 BC009988.2 BC014232.2 BC027713.2 BC129981.1 

    Selected DOTS entries (see all 55):

    DT.100657185  DT.97783107  DT.95278552  DT.100051865  DT.100801399  DT.121461046  DT.100657187  DT.97862461 
    DT.100657191  DT.97862463  DT.95322625  DT.100657195  DT.100059695  DT.92466227  DT.99960877  DT.100767935 
    DT.95278403  DT.121461117  DT.121460828  DT.121460817  DT.80101398  DT.91859894  DT.95321430  DT.100657188 

    Selected AceView cDNA sequences (see all 913):

    BU557212 BQ184682 BQ960160 BQ948042 BM928590 BM827653 BQ774081 BM548838 
    BQ062252 AA127236 BQ218357 BM697125 BU154708 BQ889720 BQ883743 C14537 
    BF971705 AK001229 BM457954 BQ065566 AA602741 NM_144733 BE002786 BM838106 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPUL1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b ^
    SP1:                                                                    -     -                                                                                 
    SP2:              -     -                                               -     -                                                                                 
    SP3:                                                                    -     -                                                                                 
    SP4:                                                                    -     -                                                                                 
    SP5:                                                                    -     -                                                                                 

    ExUns: 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for HNRNPUL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HNRNPUL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTTGGTTG
    HNRNPUL1 Expression
    About this image


    HNRNPUL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    HNRNPUL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPUL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.155218
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HNRNPUL1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpul11 , 5 heterogeneous nuclear ribonucleoprotein U-like 11, 5 90.89(n)1
    95.91(a)1
      7 (14.00 cM)5
    2329891  NM_144922.21  NP_659171.11 
     257220365 
    chicken
    (Gallus gallus)
    Aves HNRNPUL11 heterogeneous nuclear ribonucleoprotein U-like 1 72.91(n)
    78.22(a)
      776596  XM_001236109.3  XP_001236110.3 
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPUL16
    heterogeneous nuclear ribonucleoprotein U-like 1
    67(a)
    1 ↔ 1
    LGf(3651843-3684612)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF521794.12   -- 77.84(n)    CF521794.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb53d102 wufb53d10 73.72(n)   322215  CD757881.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG301226
    --
    19(a)
    1 → many
    2R(14519833-14526773)
    worm
    (Caenorhabditis elegans)
    Secernentea Y41E3.116
    Protein Y41E3.11, isoform a
    10(a)
    1 → many
    IV(15040075-15049283) WBGene00012769


    ENSEMBL Gene Tree for HNRNPUL1 (if available)
    TreeFam Gene Tree for HNRNPUL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPUL1 gene
    HNRNPUL22  HNRNPUL2-BSCL22  HNRNPU2  
    5 SIMAP similar genes for HNRNPUL1 using alignment to 12 protein entries:     HNRL1_HUMAN (see all proteins):
    HNRPUL1    HNRNPU    HNRPU    HNRNPUL2-BSCL2    HNRNPUL2

    Find genes that share paralogs with HNRNPUL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPUL1 (see all 897)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920530741,2
    --41768621(+) CATCTA/GCACTG 2 -- us2k1 int10--------
    rs1823253821,2
    --41768650(+) AAAGCA/GGATCG 2 -- us2k1 int10--------
    rs1418995661,2
    --41768867(+) TTGAAC/TACGGG 2 -- us2k1 int10--------
    rs30827351,2
    C--41768967(+) aaaaa-/A/    
       AA
    /AG
    gaaCA
    2 -- us2k1 int1 trp31NA 2
    rs588392041,2
    C--41768968(+) AAAAA-/G/GA  
            
    ACAAC
    2 -- us2k1 int10--------
    rs1997551741,2
    C--41768968(-) TTGTTC/TTNNNN 2 -- us2k1 int10--------
    rs37606601,2
    C,F,A,H--41769025(-) CGCAGT/ACGTAA 2 -- us2k1 int114Minor allele frequency- A:0.18NA NS EA WA 926
    rs1455485971,2
    --41769075(+) TGCGGA/GCTTAA 2 -- us2k1 int10--------
    rs37606591,2
    C,F,A,H--41769104(-) CAGACT/GCCCAC 2 -- us2k1 int128Minor allele frequency- G:0.22NA NS EA WA CSA 2855
    rs1510766271,2
    --41769416(+) GGCCGC/TGGACT 2 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for HNRNPUL1 (41768391 - 41813811 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HNRNPUL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911769CNV Loss21882294
    esv26941CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPUL1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605800    OMIM disorders: --


    Find genes that share disorders with HNRNPUL1           About GenesLikeMe

    Genetic Association Database (GAD): HNRNPUL1
    Human Genome Epidemiology (HuGE) Navigator: HNRNPUL1 (0 documents)

    Export disorders for HNRNPUL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPUL1 gene, integrated from 10 sources (see all 73):
    (articles sorted by number of sources associating them with HNRNPUL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. E1B-55kilodalton-associated protein: a cellular protein with RNA- binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs. (PubMed id 9733834)1, 2, 3, 9 Gabler S.... Dobner T. (J. Virol. 1998)
    2. Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. (PubMed id 12489984)1, 2, 3 Kzhyshkowska J.G.... Dobner T. (Biochem. J. 2003)
    3. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. (PubMed id 18599554)1, 4, 9 van der Net J.B....Sijbrands E.J. (Eur. Heart J. 2008)
    4. Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia. (PubMed id 19166692)1, 4 van der Net J.B....Steyerberg E.W. (Am. J. Cardiol. 2009)
    5. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. (PubMed id 19056482)1, 4 Yoshida T....Yamada Y. (Genomics 2009)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. The interaction of the hnRNP family member E1B-AP5 with p53. (PubMed id 15907477)1, 2 Barral P.M.... Grand R.J. (FEBS Lett. 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Protein arginine methylation during lytic adenovirus infection. (PubMed id 15242333)1, 2 Kzhyshkowska J.... Dobner T. (Biochem. J. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11100 HGNC: 17011 AceView: HNRPUL1 Ensembl:ENSG00000105323 euGenes: HUgn11100
    ECgene: HNRNPUL1 Kegg: 11100 H-InvDB: HNRNPUL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HNRNPUL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPUL1 gene:
    Search GeneIP for patents involving HNRNPUL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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