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Aliases for HNRNPUL1 Gene

Aliases for HNRNPUL1 Gene

  • Heterogeneous Nuclear Ribonucleoprotein U-Like 1 2 3
  • HNRPUL1 3 4 6
  • E1BAP5 3 4 6
  • Adenovirus Early Region 1B-Associated Protein 5 3 4
  • E1B-55 KDa-Associated Protein 5 3 4
  • E1B 55kDa Associated Protein 5 2 3
  • E1B-AP5 3 4
  • Heterogeneous Nuclear Ribonucleoprotein U-Like Protein 1 3
  • E1B-55kDa-Associated Protein 5 3

External Ids for HNRNPUL1 Gene

Previous HGNC Symbols for HNRNPUL1 Gene

  • HNRPUL1

Previous GeneCards Identifiers for HNRNPUL1 Gene

  • GC19P046463
  • GC19P041768
  • GC19P038200

Summaries for HNRNPUL1 Gene

Entrez Gene Summary for HNRNPUL1 Gene

  • This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. Two transcript variants encoding different isoforms have been found for this gene. Additional variants have also been found, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPUL1 Gene

HNRNPUL1 (Heterogeneous Nuclear Ribonucleoprotein U-Like 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Influenza A. GO annotations related to this gene include RNA binding and enzyme binding. An important paralog of this gene is HNRNPUL2-BSCL2.

UniProtKB/Swiss-Prot for HNRNPUL1 Gene

  • Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.

Gene Wiki entry for HNRNPUL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPUL1 Gene

Genomics for HNRNPUL1 Gene

Regulatory Elements for HNRNPUL1 Gene

Transcription factor binding sites by QIAGEN in the HNRNPUL1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HNRNPUL1 Gene

Start:
41,262,486 bp from pter
End:
41,307,906 bp from pter
Size:
45,421 bases
Orientation:
Plus strand

Genomic View for HNRNPUL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPUL1 Gene

Proteins for HNRNPUL1 Gene

  • Protein details for HNRNPUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUJ2-HNRL1_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein U-like protein 1
    Protein Accession:
    Q9BUJ2
    Secondary Accessions:
    • B3KMW7
    • O76022
    • Q6ZSZ0
    • Q7L8P4
    • Q8N6Z4
    • Q96G37
    • Q9HAL3
    • Q9UG75

    Protein attributes for HNRNPUL1 Gene

    Size:
    856 amino acids
    Molecular mass:
    95739 Da
    Quaternary structure:
    • Interacts with the adenovirus type 5 (Ad5) E1B-55 kDa, BRD7, PRMT2, TP53 and NXF1. Associates with histones and BRD7.
    Miscellaneous:
    • Its methylation is enhanced in the late phase of adenoviral infection

    Alternative splice isoforms for HNRNPUL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPUL1 Gene

Proteomics data for HNRNPUL1 Gene at MOPED

Post-translational modifications for HNRNPUL1 Gene

No data available for DME Specific Peptides for HNRNPUL1 Gene

Domains for HNRNPUL1 Gene

Protein Domains for HNRNPUL1 Gene

Suggested Antigen Peptide Sequences for HNRNPUL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BUJ2

UniProtKB/Swiss-Prot:

HNRL1_HUMAN :
  • Q9BUJ2
Domain:
  • The RGG-box domain is methylated
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 SAP domain.
genes like me logo Genes that share domains with HNRNPUL1: view

No data available for Gene Families for HNRNPUL1 Gene

Function for HNRNPUL1 Gene

Molecular function for HNRNPUL1 Gene

UniProtKB/Swiss-Prot Function: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.

Gene Ontology (GO) - Molecular Function for HNRNPUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 9733834
GO:0005515 protein binding IPI 12489984
GO:0019899 enzyme binding IPI 11513728
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HNRNPUL1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPUL1 Gene

Localization for HNRNPUL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPUL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPUL1 Gene COMPARTMENTS Subcellular localization image for HNRNPUL1 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for HNRNPUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11513728
GO:0005654 nucleoplasm TAS --
GO:0019013 viral nucleocapsid --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with HNRNPUL1: view

Pathways for HNRNPUL1 Gene

genes like me logo Genes that share pathways with HNRNPUL1: view

Pathways by source for HNRNPUL1 Gene

1 KEGG pathway for HNRNPUL1 Gene

Gene Ontology (GO) - Biological Process for HNRNPUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006396 RNA processing TAS 9733834
GO:0008380 RNA splicing TAS --
genes like me logo Genes that share ontologies with HNRNPUL1: view

Transcripts for HNRNPUL1 Gene

Unigene Clusters for HNRNPUL1 Gene

Heterogeneous nuclear ribonucleoprotein U-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPUL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b ^
SP1: - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:
SP8: - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7: -
SP8:
SP9: -
SP10: -
SP11: -
SP12:
SP13:
SP14:

Relevant External Links for HNRNPUL1 Gene

GeneLoc Exon Structure for
HNRNPUL1
ECgene alternative splicing isoforms for
HNRNPUL1

Expression for HNRNPUL1 Gene

mRNA expression in normal human tissues for HNRNPUL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPUL1 Gene

SOURCE GeneReport for Unigene cluster for HNRNPUL1 Gene Hs.155218

genes like me logo Genes that share expressions with HNRNPUL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPUL1 Gene

Orthologs for HNRNPUL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPUL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPUL1 35
  • 99.84 (n)
  • 99.88 (a)
HNRNPUL1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HNRNPUL1 35
  • 92.45 (n)
  • 96.61 (a)
HNRNPUL1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPUL1 35
  • 93.85 (n)
  • 98.48 (a)
HNRNPUL1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpul1 35
  • 90.89 (n)
  • 95.91 (a)
Hnrnpul1 16
Hnrnpul1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPUL1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPUL1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnpul1 35
  • 90.78 (n)
  • 96.24 (a)
chicken
(Gallus gallus)
Aves HNRNPUL1 35
  • 72.91 (n)
  • 78.22 (a)
HNRNPUL1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPUL1 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FP085405.1 36
  • 55 (a)
OneToMany
hnrnpul1 36
  • 55 (a)
OneToMany
LOC100330645 35
  • 67.76 (n)
  • 68.58 (a)
wufb53d10 35
fruit fly
(Drosophila melanogaster)
Insecta CG30122 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y41E3.11 36
  • 10 (a)
OneToMany
Species with no ortholog for HNRNPUL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HNRNPUL1 Gene

ENSEMBL:
Gene Tree for HNRNPUL1 (if available)
TreeFam:
Gene Tree for HNRNPUL1 (if available)

Paralogs for HNRNPUL1 Gene

Paralogs for HNRNPUL1 Gene

genes like me logo Genes that share paralogs with HNRNPUL1: view

Variants for HNRNPUL1 Gene

Sequence variations from dbSNP and Humsavar for HNRNPUL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10826 -- 41,307,108(+) TTATG(C/T)GCTTT utr-variant-3-prime
rs12745 -- 41,305,825(+) CCCAC(C/G/T)GCACA synonymous-codon, reference
rs15052 -- 41,307,470(-) GGGAG(A/G)AACTT utr-variant-3-prime
rs998468 -- 41,295,569(-) AAACA(C/T)AGAAA intron-variant
rs1056852 -- 41,264,582(+) TCAAG(A/G)CCGAG missense, reference, intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HNRNPUL1 Gene

Variant ID Type Subtype PubMed ID
esv26941 CNV Gain 19812545
nsv911769 CNV Loss 21882294

Relevant External Links for HNRNPUL1 Gene

HapMap Linkage Disequilibrium report
HNRNPUL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPUL1 Gene

Disorders for HNRNPUL1 Gene

Relevant External Links for HNRNPUL1

Genetic Association Database (GAD)
HNRNPUL1
Human Genome Epidemiology (HuGE) Navigator
HNRNPUL1
genes like me logo Genes that share disorders with HNRNPUL1: view

No data available for UniProtKB/Swiss-Prot for HNRNPUL1 Gene

Publications for HNRNPUL1 Gene

  1. E1B-55kilodalton-associated protein: a cellular protein with RNA- binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs. (PMID: 9733834) Gabler S. … Dobner T. (J. Virol. 1998) 2 3 4 23
  2. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. (PMID: 18599554) van der Net J.B. … Sijbrands E.J. (Eur. Heart J. 2008) 3 23 48
  3. Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. (PMID: 12489984) Kzhyshkowska J.G. … Dobner T. (Biochem. J. 2003) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HNRNPUL1 Gene

  • antibodies-online peptides for HNRNPUL1
  • antibodies-online antibodies for HNRNPUL1
  • antibodies-online kits for HNRNPUL1

Sources for HNRNPUL1 Gene

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