Aliases for HNRNPU Gene
Aliases for HNRNPU Gene
External Ids for HNRNPU Gene
- HGNC: 5048
- Entrez Gene: 3192
- Ensembl: ENSG00000153187
- OMIM: 602869
- UniProtKB: Q00839
Previous HGNC Symbols for HNRNPU Gene
- HNRPU
- HNRNPU-AS1
- C1orf199
- NCRNA00201
Previous GeneCards Identifiers for HNRNPU Gene
- GC01M243081
- GC01M245013
- GC01M215396
Summaries for HNRNPU Gene
-
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNRNPU Gene
HNRNPU (Heterogeneous Nuclear Ribonucleoprotein U) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Circadian rythm related genes. GO annotations related to this gene include poly(A) RNA binding and kinase activity. An important paralog of this gene is HNRNPUL1.
UniProtKB/Swiss-Prot for HNRNPU Gene
-
Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single-stranded DNA and RNA. Plays a role in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPU Gene
Genomics for HNRNPU Gene
Regulatory Elements for HNRNPU Gene
Enhancers for HNRNPU Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G244860 | 1.7 | Ensembl ENCODE dbSUPER | 0.7 | +1.0 | 991 | 6.7 | MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF548 ZNF263 SP3 NFYC | COX20 ADSS HNRNPU |
| GH01G244858 | 1.9 | Ensembl dbSUPER | 0.4 | +10.2 | 10160 | 0.4 | SCRT1 PAF1 ZNF362 ZFP37 BCL11B ZNF335 CTBP1 ZSCAN16 | RNU6-947P HNRNPU COX20 |
| GH01G244832 | 1.5 | ENCODE dbSUPER | 0.3 | +29.0 | 28962 | 6.4 | MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 | COX20 ADSS HNRNPU |
| GH01G244839 | 1.1 | ENCODE dbSUPER | 0.3 | +23.3 | 23338 | 2.6 | YBX3 CBX3 AGO1 INSM2 ZNF121 CBX5 ZSCAN5C ZNF143 RELB ZNF280D | COX20 RNU6-947P HNRNPU |
| GH01G244854 | 0.7 | dbSUPER | 0.4 | +9.3 | 9311 | 1.0 | ZNF384 BCL11B ZIC2 ZNF335 ZFHX2 POLR2A EED EGR2 PAF1 SCRT1 | COX20 RNU6-947P HNRNPU |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HNRNPU on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HNRNPU gene promoter:
Regulatory Element Products
Genomic Location for HNRNPU Gene
- Chromosome:
- 1
- Start:
- 244,840,638 bp from pter
- End:
- 244,864,560 bp from pter
- Size:
- 23,923 bases
- Orientation:
- Minus strand
Genomic View for HNRNPU Gene
Genes around HNRNPU on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q44 by Ensembl
- 1q44 by Entrez Gene
- 1q44 by HGNC
HNRNPU Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPU Gene
Proteins for HNRNPU Gene
-
Protein details for HNRNPU Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q00839-HNRPU_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoprotein U
- Protein Accession:
- Q00839
- O75507
- Q8N174
- Q96HY9
- Q9BQ09
Protein attributes for HNRNPU Gene
- Size:
- 825 amino acids
- Molecular mass:
- 90584 Da
- Quaternary structure:
-
- Identified in the spliceosome C complex. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1, IGF2BP2, IGF2BP3 and ERBB4. Ligand for CR2. Interacts with CRY1 (By similarity). Interacts with UBQLN2 (PubMed:25616961). Interacts with GEMIN5 (PubMed:25911097).
- SequenceCaution:
-
- Sequence=AAC19382.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
Protein Expression for HNRNPU Gene
Post-translational modifications for HNRNPU Gene
- Arg-739 is dimethylated, probably to asymmetric dimethylarginine.
- Citrullinated by PADI4.
- Extensively phosphorylated.
- Ubiquitination at isoforms=29, isoforms=2186, isoforms=2464, isoforms=2516, isoforms=2524, posLast=536536, isoforms=2544, isoforms=2565, isoforms=2602, isoforms=2635, and isoforms=2814
- Modification sites at PhosphoSitePlus
Other Protein References for HNRNPU Gene
- ENSEMBL proteins:
-
- ENSP00000393151
- ENSP00000410728
- ENSP00000479468
- ENSP00000482621
- ENSP00000490988
- ENSP00000491215
- ENSP00000491263
- ENSP00000491294
- ENSP00000491305
- ENSP00000491340
- ENSP00000491491
- ENSP00000491601
- ENSP00000491685
- ENSP00000491807
- ENSP00000491903
- ENSP00000492010
- ENSP00000492573
- ENSP00000492620
- ENSP00000283179
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HNRNPU
- Novus Biologicals Antibodies for HNRNPU
- Invitrogen Antibodies for HNRNPU
- antibodies-online Antibodies for HNRNPU: See all 52
- GeneTex HNRNPU antibody for HNRNPU
-
Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPU
Protein Products
-
OriGene Purified Proteins for HNRNPU
- Search Origene for MassSpec and Protein Over-expression Lysates for HNRNPU
- Origene Custom Protein Services for HNRNPU
- antibodies-online Proteins for HNRNPU: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HNRNPU
Assay Products
- antibodies-online Kits for HNRNPU: See all 30
No data available for DME Specific Peptides for HNRNPU Gene
Domains & Families for HNRNPU Gene
Protein Domains for HNRNPU Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPU Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ44920 fis, clone BRAMY3011501, highly similar to Heterogeneous nuclear ribonucleoprotein U (B3KX72_HUMAN)
- pp120 (HNRPU_HUMAN)
- Heterogeneous nuclear ribonucleoprotein U (Scaffold attachment factor A) (Q5RI17_HUMAN)
- Heterogeneous nuclear ribonucleoprotein U (Scaffold attachment factor A) (Q5RI19_HUMAN)
- Heterogeneous nuclear ribonucleoprotein U (Scaffold attachment factor A), isoform CRA_a (Q7Z4Q5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for HNRNPU Gene
Function for HNRNPU Gene
Molecular function for HNRNPU Gene
- UniProtKB/Swiss-Prot Function:
- Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single-stranded DNA and RNA. Plays a role in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001047 | core promoter binding | ISS | -- |
| GO:0003677 | DNA binding | TAS | 1628625 |
| GO:0003723 | RNA binding | TAS,IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 17289661 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for HNRNPU Gene
- MGI mutant phenotypes for HNRNPU:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HNRNPU:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
- Decreased POU5F1-GFP protein expression
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased G1 DNA content
- G0/1 arrest
- Increased transcriptional activity
- Decreased HIV-LTR-beta-galactosidase protein expression
- Increased HPV16-GFP infection
- Decreased influenza A virus infection
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Decreased interferon-beta reporter expression
- Decreased centriole number
- Decreased viability
- Increased SMN2 exon 7 inclusion
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPU gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPU gene
- Search ViGene Biosciences for HNRNPU
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPU
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPU
- GenScript: Design CRISPR guide RNA sequences for HNRNPU
miRNA for HNRNPU Gene
- miRTarBase miRNAs that target HNRNPU
-
- hsa-mir-1-3p (MIRT005282)
- hsa-mir-7-5p (MIRT025868)
- hsa-mir-615-3p (MIRT039706)
- hsa-mir-186-5p (MIRT045256)
- hsa-mir-149-5p (MIRT045483)
- hsa-mir-27b-3p (MIRT046200)
- hsa-mir-30c-5p (MIRT047974)
- hsa-mir-26a-5p (MIRT050141)
- hsa-mir-17-5p (MIRT050837)
- hsa-mir-493-3p (MIRT113132)
- hsa-mir-3611 (MIRT113135)
- hsa-mir-548g-3p (MIRT135069)
- hsa-mir-548av-3p (MIRT135086)
- hsa-let-7c-3p (MIRT186644)
- hsa-mir-3668 (MIRT475549)
- hsa-mir-3163 (MIRT475550)
- hsa-mir-577 (MIRT475551)
- hsa-mir-5683 (MIRT475552)
- hsa-mir-6732-3p (MIRT475553)
- hsa-mir-3662 (MIRT475554)
- hsa-mir-7850-5p (MIRT511443)
- hsa-mir-578 (MIRT511444)
- hsa-mir-620 (MIRT511445)
- hsa-mir-1270 (MIRT511446)
- hsa-mir-4531 (MIRT511447)
- hsa-mir-3924 (MIRT511448)
- hsa-mir-539-5p (MIRT511449)
- hsa-mir-6505-3p (MIRT511450)
- hsa-mir-4277 (MIRT511451)
- hsa-mir-5094 (MIRT511452)
- hsa-mir-584-3p (MIRT511453)
- hsa-mir-329-5p (MIRT511454)
- hsa-mir-7159-3p (MIRT523148)
- hsa-mir-3678-3p (MIRT523149)
- hsa-mir-198 (MIRT523150)
- hsa-mir-2467-3p (MIRT523151)
- hsa-mir-320e (MIRT523152)
- hsa-mir-3133 (MIRT523153)
- hsa-mir-6835-3p (MIRT523154)
- hsa-mir-190a-3p (MIRT547916)
- hsa-mir-5011-5p (MIRT547917)
- hsa-mir-34a-3p (MIRT547918)
- hsa-mir-5692a (MIRT547919)
- hsa-mir-410-3p (MIRT547920)
- hsa-mir-4516 (MIRT547921)
- hsa-mir-5703 (MIRT547922)
- hsa-mir-4434 (MIRT547923)
- hsa-mir-548x-3p (MIRT557197)
- hsa-mir-548aq-3p (MIRT557198)
- hsa-mir-548aj-3p (MIRT557199)
- hsa-mir-548ae-3p (MIRT557200)
- hsa-mir-3613-3p (MIRT557201)
- hsa-mir-551b-5p (MIRT557202)
- hsa-mir-548c-3p (MIRT557203)
- hsa-mir-6809-3p (MIRT706075)
- hsa-mir-4753-3p (MIRT706076)
- hsa-mir-517c-3p (MIRT706077)
- hsa-mir-517b-3p (MIRT706078)
- hsa-mir-517a-3p (MIRT706079)
- hsa-mir-2117 (MIRT706080)
- hsa-mir-597-3p (MIRT706081)
- hsa-mir-8077 (MIRT706082)
- hsa-mir-7160-5p (MIRT706083)
- hsa-mir-4663 (MIRT706084)
- hsa-mir-6086 (MIRT706085)
- hsa-mir-377-5p (MIRT706086)
- hsa-mir-655-5p (MIRT706087)
- hsa-mir-642b-3p (MIRT706088)
- hsa-mir-642a-3p (MIRT706089)
- hsa-mir-7162-3p (MIRT706090)
- hsa-mir-6730-3p (MIRT706091)
- hsa-mir-4536-3p (MIRT706092)
- hsa-mir-4728-3p (MIRT706093)
- hsa-mir-888-3p (MIRT706094)
- hsa-mir-30e-3p (MIRT725409)
- hsa-mir-30d-3p (MIRT725410)
- hsa-mir-30a-3p (MIRT725411)
- hsa-mir-3942-3p (MIRT725412)
- hsa-mir-5100 (MIRT725413)
- hsa-mir-1245b-3p (MIRT725414)
- hsa-mir-501-5p (MIRT725415)
- hsa-mir-19b-3p (MIRT727486)
- hsa-mir-19a-3p (MIRT727487)
miRNA Products
- Search ViGene Biosciences for HNRNPU
- SwitchGear HNRNPU 3' UTR sequence
- SwitchGear HNRNPU 3' UTR sequence
- Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HNRNPU
- Browse OriGene Inhibitory RNA Products For HNRNPU
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPU gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HNRNPU
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for HNRNPU gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPU gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPU gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPU Gene
Localization for HNRNPU Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPU Gene
- Nucleus. Cytoplasm. Cell surface. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. {ECO:0000269 PubMed:17289661}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| cytoskeleton | 3 |
| cytosol | 2 |
| plasma membrane | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 22720776 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IEA | -- |
| GO:0005697 | colocalizes_with telomerase holoenzyme complex | IDA | 18082603 |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for HNRNPU Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.50
.41
|
| 2 | Gene Expression |
.48
|
|
| 3 | Circadian rythm related genes | ||
Pathways by source for HNRNPU Gene
2 BioSystems pathways for HNRNPU Gene
4 Reactome pathways for HNRNPU Gene
1 KEGG pathway for HNRNPU Gene
Interacting Proteins for HNRNPU Gene
Selected Interacting proteins:
Q00839-HNRPU_HUMAN
ENSP00000283179
for HNRNPU Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0001649 | osteoblast differentiation | IDA | 16210410 |
| GO:0006396 | RNA processing | TAS | 1628625 |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | IEA | -- |
Transcripts for HNRNPU Gene
mRNA/cDNA for HNRNPU Gene
- (5) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (1297) Selected AceView cDNA sequences:
- (30) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HNRNPU Gene
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPU
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPU
- GenScript: Design CRISPR guide RNA sequences for HNRNPU
miRNA Products
- Search ViGene Biosciences for HNRNPU
- SwitchGear HNRNPU 3' UTR sequence
- SwitchGear HNRNPU 3' UTR sequence
- Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HNRNPU
- Browse OriGene Inhibitory RNA Products For HNRNPU
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPU gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HNRNPU
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for HNRNPU Gene
This gene is overexpressed in Lymph node (10.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPU Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HNRNPU Gene:
HNRNPUSOURCE GeneReport for Unigene cluster for HNRNPU Gene:
Hs.106212Evidence on tissue expression from TISSUES for HNRNPU Gene
- Nervous system(4.9)
- Blood(4.8)
- Skin(4.8)
- Liver(4.7)
- Eye(4.6)
- Lung(4.5)
- Kidney(3.9)
- Intestine(3.8)
- Muscle(2.6)
- Spleen(2.3)
- Bone(2.2)
- Bone marrow(2.2)
- Heart(2.2)
- Pancreas(2.2)
- Lymph node(2.1)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for HNRNPU
-
OriGene qPCR primer pairs for HNRNPU
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPU Gene
Orthologs for HNRNPU Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HNRNPU 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HNRNPU 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HNRNPU 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HNRNPU 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hnrnpu 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hnrnpu 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HNRNPU 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HNRNPU 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HNRNPU 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hnrnpu 34 |
|
||
| Str.7999 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8951 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hnrnpub 34 35 |
|
||
| hnrnpua 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG30122 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | Y41E3.11 35 |
|
OneToMany |
- Species where no ortholog for HNRNPU was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HNRNPU Gene
(4) SIMAP similar genes for HNRNPU Gene using alignment to 2 proteins:
Variants for HNRNPU Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs587777004 | Pathogenic | 244,842,055(+) | TGTTC(A/C)CTAGT | intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense | |
| rs794729648 | Pathogenic | 244,855,471(-) | AACAG(-/AG)GGAAC | upstream-variant-2KB, reference, frameshift-variant | |
| rs886041983 | Pathogenic | 244,863,788(-) | AGCCC(C/T)AACAG | reference, stop-gained | |
| rs147700538 | Likely pathogenic | 244,842,234(+) | AGGGT(G/T)TATCT | nc-transcript-variant, reference, missense, utr-variant-3-prime | |
| rs373824502 | Likely pathogenic | 244,841,992(+) | GCGCC(A/C/T)GGCAT | intron-variant, nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon, missense |
Residual Variation Intolerance Score:
14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.21;
24.28% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HNRNPU Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPU Gene
Disorders for HNRNPU Gene
Relevant External Links for HNRNPU
No disorders were found for HNRNPU Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPU Gene
Publications for HNRNPU Gene
- hnRNP-U/SAF-A is encoded by two differentially polyadenylated mRNAs in human cells. (PMID: 7509195) Fackelmayer F.O. … Richter A. (Biochim. Biophys. Acta 1994) 2 3 4 22 64
- Purification of two isoforms of hnRNP-U and characterization of their nucleic acid binding activity. (PMID: 8068679) Fackelmayer F.O. … Richter A. (Biochemistry 1994) 2 3 4 22 64
- Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins. (PMID: 7993898) Jordan P. … Kubler D. (Biochemistry 1994) 3 4 22 64
- Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box. (PMID: 1628625) Kiledjian M. … Dreyfuss G. (EMBO J. 1992) 3 4 22 64
- ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1. (PMID: 25616961) Gilpin K.M. … Monteiro M.J. (Hum. Mol. Genet. 2015) 3 4 64
Products for HNRNPU Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HNRNPU
- Search Origene for MassSpec and Protein Over-expression Lysates for HNRNPU
- Origene Custom Protein Services for HNRNPU
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HNRNPU
- Browse OriGene Inhibitory RNA Products For HNRNPU
- OriGene qPCR primer pairs and template standards for HNRNPU
- OriGene qPCR primer pairs for HNRNPU
- OriGene CRISPR knockouts for HNRNPU
- OriGene ORF clones in human for HNRNPU
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HNRNPU
- GenScript: Next-day shipping cDNA ORF clone for HNRNPU in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HNRNPU
- GenScript Custom Assay Services for HNRNPU
- GenScript Custom overexpressing Cell Line Services for HNRNPU
- GenScript: Design CRISPR guide RNA sequences for HNRNPU
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HNRNPU
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HNRNPU
- Novus Biologicals proteins and lysates for HNRNPU
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Addgene plasmids for HNRNPU
- antibodies-online Antibodies for HNRNPU: See all 52
- antibodies-online Kits for HNRNPU: See all 30
- antibodies-online Proteins for HNRNPU: See all 4
- Search antibodies-online for peptides
- GeneTex HNRNPU antibody for HNRNPU
- Search GeneTex for Proteins for HNRNPU
- ViGene Biosciences adenoviral particle packaged cDNA for HNRNPU gene
- ViGene Biosciences lentiviral particle packaged cDNA for HNRNPU gene
- ViGene Biosciences ready-to-package AAV shRNAs for HNRNPU gene
- Search ViGene Biosciences for HNRNPU
- Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPU
- Search Santa Cruz Biotechnology (SCBT) for HNRNPU siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPU
- Cyagen custom Knockout/knockin (KOKI) mouse models for HNRNPU
- VectorBuilder custom plasmid, inducible vectors for HNRNPU
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HNRNPU
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HNRNPU Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer