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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HNRNPU Gene

protein-coding GIFtS: 57
GCID: GC01M245013

heterogeneous nuclear ribonucleoprotein U (scaffold attachment...

(Previous symbol: HNRPU)

Explore 21 diseases affiliated with
HNRNPU via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A)¹ ²		Pp120¹
HNRPU¹ ² ³		HnRNPU¹
SAF-A¹ ² ³		Heterogeneous Nuclear Ribonucleoprotein U²
Scaffold Attachment Factor A² ³		P120 Nuclear Protein²
U21.1² ³		SAFA³
HnRNP U² ³		P120¹

External Ids:	HGNC: 5048¹	Entrez Gene: 3192²	Ensembl: ENSG00000153187⁷	OMIM: 602869⁵	UniProtKB: Q00839³

Export aliases for HNRNPU gene to outside databases

Previous GC identifers: GC01M243081 GC01M215396

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HNRNPU:

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The

hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are

associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA

metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus

and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene

contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein

is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis,

this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of

DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage

does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript

variants have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HNRPU_HUMAN, Q00839

Function: Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high

affinity for scaffold-attached region (SAR) DNA. Binds to double- and single-stranded DNA and RNA

Gene Wiki entry for HNRNPU (HNRPU)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HNRNPU gene promoter:
CREB deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HNRNPU promoter sequence

Search SABiosciences Chromatin IP Primers for HNRNPU

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPU

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44

HNRNPU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPU gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M245013: view genomic region (about GC identifiers)

Start:	245,013,602 bp from pter	End:	245,027,844 bp from pter
Size:	14,243 bases	Orientation:	minus strand

1 alternative location:

Chr7+,CRA_TCAG 53,579,447-53,579,947

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HNRPU_HUMAN, Q00839 (See protein sequence)

Recommended Name: Heterogeneous nuclear ribonucleoprotein U

Size: 825 amino acids; 90584 Da

Subunit: Identified in the spliceosome C complex. Component of the coding region determinant (CRD)-mediated complex,

composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X,

ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule

complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU,

HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP,

TROVE2, YBX1 and untranslated mRNAs. Interacts with IGF2BP1 and ERBB4. Ligand for CR2

Subcellular location: Nucleus. Cytoplasm. Cell surface. Note=Localized in cytoplasmic mRNP granules containing

untranslated mRNAs. Component of ribonucleosomes. Also found associated with the cell surface

Sequence caution: Sequence=AAC19382.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;

1 PDB 3D structure from and Proteopedia for HNRNPU:

1ZRJ (3D)

Secondary accessions: O75507 Q8N174 Q96HY9 Q9BQ09

Alternative splicing: 2 isoforms: Q00839-1 Q00839-2 (Contains a N6-acetyllysine at position 215)

Explore the universe of human proteins at neXtProt for HNRNPU: NX_Q00839

Post-translational modifications:

Extensively phosphorylated¹

Arg-733 and Arg-739 are dimethylated, probably to asymmetric dimethylarginine¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q00839

HNRNPU Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004492.2 NP_114032.2

ENSEMBL proteins:

ENSP00000393151 ENSP00000283179 ENSP00000410728

Reactome Protein details: Q00839
Human Recombinant Protein Products for HNRNPU:

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	Uscn Proteins for HNRNPU

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0009986	cell surface	IEA	--
GO:0030529	ribonucleoprotein complex	IDA	17289661
GO:0030530	heterogeneous nuclear ribonucleoprotein complex	--	--
GO:0070937	CRD-mediated mRNA stability complex	IDA	19029303

HNRNPU for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for HNRNPU

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HNRNPU for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001870 B30.2/SPRY

IPR026745 hnRNP_U

IPR003877 SPRY_rcpt

IPR003034 SAP_dom

IPR018355 SPla/RYanodine_receptor_subgr

Graphical View of Domain Structure for InterPro Entry Q00839

ProtoNet protein and cluster: Q00839

1 Blocks protein family: IPB003034 DNA-binding SAP

UniProtKB/Swiss-Prot: HNRPU_HUMAN, Q00839

Similarity: Contains 1 B30.2/SPRY domain

Similarity: Contains 1 SAP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: HNRPU_HUMAN, Q00839

Function: Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high

affinity for scaffold-attached region (SAR) DNA. Binds to double- and single-stranded DNA and RNA

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	19174163
GO:0005524	ATP binding	IEA	--

HNRNPU for ontologies About GeneDecksing

Phenotypes:
8 GenomeRNAi human phenotypes for HNRNPU:

Decreased NANOG protein expres	Decreased OCT4 protein express	Decreased POU5F1-GFP protein e	Decreased influenza A virus in
Decreased viability	Increased S DNA content	Increased gamma-H2AX phosphory	S arrest

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hnrnpu):

embryogenesis

growth/size

mortality/aging

HNRNPU for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HNRNPU

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		8/159 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRNPU (see all 159):
		hsa-miR-517a hsa-miR-877* hsa-miR-637 hsa-miR-298 hsa-miR-1243 hsa-miR-200b hsa-miR-642b hsa-miR-92b

		SwitchGear 3'UTR luciferase reporter plasmids (see all 2): HNRNPU 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPU

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing	1.00	mRNA Processing	0.82
mRNA Splicing - Major Pathway	1.00	mRNA processing	0.48
Processing of Capped Intron-Containing Pre-mRNA	0.96	Spliceosome	0.31

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for HNRNPU

mRNA processing

5 Reactome Pathways for HNRNPU

	mRNA Splicing - Major Pathway
	mRNA Splicing
	Gene Expression
	mRNA Processing
	Processing of Capped Intron-Containing Pre-mRNA

1 Kegg Pathway (Kegg details for HNRNPU):

Spliceosome

HNRNPU for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HNRNPU

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/1022 Interacting proteins for HNRNPU (Q00839^{1, 2, 3} ENSP00000283179⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 1022)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMN1	Q16637²^,³, ENSP00000370083⁴	MINT-18162 MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370083
RUVBL2	Q9Y230²^,³, ENSP00000221413⁴	MINT-7945693 MINT-6489355 MINT-7947479 I2D: score=1 STRING: ENSP00000221413
HNRNPH1	P31943²^,³, ENSP00000349168⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349168
RBM39	Q14498²^,³, ENSP00000253363⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000253363
SNW1	Q13573²^,³, ENSP00000261531⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000261531

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0006396	RNA processing	TAS	1628625
GO:0008380	RNA splicing	TAS	--
GO:0010467	gene expression	TAS	--
GO:0070934	CRD-mediated mRNA stabilization	IMP	19029303

HNRNPU for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HNRNPU for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HNRNPU
3 Novoseek chemical compound relationships for HNRNPU gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	36.4	12	9642150 (2), 10356358 (2), 7515933 (1), 1725602 (1) (see all 8)
phosphotyrosine	28.8	1	7512571 (1)
heparin	0	1	8444314 (1)

Search CenterWatch for drugs/clinical trials and news about HNRNPU / HNRPU

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HNRNPU gene (2 alternative transcripts):

NM_004501.3 NM_031844.2

Unigene Cluster for HNRNPU:

Heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)

Hs.106212 [show with all ESTs]

Unigene Representative Sequence: NM_031844

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000444376(uc001iay.1 uc001iaz.1 uc001iba.1) ENST00000283179

ENST00000366525 ENST00000483966 ENST00000468690 ENST00000440865 ENST00000465881

ENST00000476241

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HNRNPU Browse OriGene MicroRNA Expression Plasmids
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		8/159 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRNPU (see all 159):
		hsa-miR-517a hsa-miR-877* hsa-miR-637 hsa-miR-298 hsa-miR-1243 hsa-miR-200b hsa-miR-642b hsa-miR-92b

		SwitchGear 3'UTR luciferase reporter plasmids (see all 2): HNRNPU 3' UTR sequence

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		Sirion Biotech Custom design and validation of potent shRNA sequences against HNRNPU

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Additional cDNA sequence:

AF068846.1 AF461014.1 AK095525.1 AK126868.1 AK130669.1 AK297119.1 AK307661.1 BC003367.1

BC003621.2 BC007950.2 BC015782.1 BC024767.1 BC034925.1 X65488.1

24/48 DOTS entries (see all 48):

DT.75162681 DT.208604 DT.95299838 DT.97781188 DT.100683711 DT.100683712 DT.100771204 DT.95225869

DT.121445578 DT.91997642 DT.95298275 DT.92465883 DT.100683700 DT.102842768 DT.121445599 DT.95299795

DT.121445611 DT.95299851 DT.87079962 DT.100848272 DT.85103493 DT.100683714 DT.121445689 DT.95193033

24/1297 AceView cDNA sequences (see all 1297):

AI919320 AA860116 AW630913 CB124277 BM838495 N91360 BF432522 AA827540

BM764876 CB215659 BM760164 AW468770 BQ072076 CA395883 AA360076 BC007950

BX340910 AI333900 BM836732 BU608066 BQ930000 AF461014 BU902347 CA392283

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPU (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b
SP1:							-		-						-																		-						-
SP2:									-						-																		-						-
SP3:							-		-		-				-
SP4:															-
SP5:

ECgene alternative splicing isoforms for HNRNPU

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HNRNPU expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

HNRNPU expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Cap Mesenchyme

Cap Mesenchyme Cells

Kidney

Bone

Mandibular Fossa

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HNRNPU Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HNRNPU

SOURCE GeneReport for Unigene cluster: Hs.106212

SABiosciences Custom PCR Arrays for HNRNPU

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HNRNPU Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HNRNPU
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRNPU

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPU

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HNRNPU gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HNRNPU¹	heterogeneous nuclear ribonucleoprotein U (scaffold more	86.13(n) 94.74(a)		421492 XM_419539.3 XP_419539.3
lizard (Anolis carolinensis)	Reptilia	HNRNPU⁶	--	75(a)	1 ↔ 1	GL343285.1(1230116-1242461)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8951²	Xenopus laevis scaffold attachment factor A (Saf-A) more	82.26(n)		AF068847.1
zebrafish (Danio rerio)	Actinopterygii	hnrnpub¹	heterogeneous nuclear ribonucleoprotein Ub	64.8(n) 63.8(a)		334490 NM_001033595.1 NP_001028767.1
fruit fly (Drosophila melanogaster)	Insecta	CG30122⁶	--	17(a)	1 → many	2R(14519833-14526773)
worm (Caenorhabditis elegans)	Secernentea	Y41E3.11⁶	Protein Y41E3.11, isoform b	9(a)	1 → many	IV(15040043-15049251)
rice (Oryza sativa)	Liliopsida	--	SPRY-domain containing protein, putative, expresse...	20(a)	1 → many	4(32163300-32166741)

ENSEMBL Gene Tree for HNRNPU (if available)
TreeFam Gene Tree for HNRNPU (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for HNRNPU gene

HNRNPUL1² HNRNPUL2² ENSG00000234857²

3 SIMAP similar genes for HNRNPU using alignment to 2 protein entries: HNRPU_HUMAN (see all proteins):

HNRPU HNRNPUL1 HNRNPUL2

HNRNPU for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for HNRNPU
PGOHUM00000248152

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150633318^1,2	C	--	245013111(+)	`ATATC-/CATTA TGAATAACATTA`	2	--	ds500¹		0	--	--	--	--
rs199802108^1,2	C	--	245013111(+)	`AATATA/CCNNNN`	2	--	ds500¹		0	--	--	--	--
rs182977459^1,2		--	245013141(+)	`ACCCAC/TCTATC`	2	--	ds500¹		0	--	--	--	--
rs142762657^1,2		--	245013318(+)	`AGACTC/GTGCTA`	2	--	ds500¹		0	--	--	--	--
rs12564642^1,2	C,F,H	--	245013357(+)	`TGTGAC/TGCCAA`	2	--	ds500¹		6		NS EA NA	540
rs148844946^1,2		--	245013549(+)	`TAATT-/AACAAGTT`	2	--	ds500¹		0	--	--	--	--
rs146061226^1,2		--	245013568(+)	`CAAAGA/GTTAGT`	2	--	ds500¹		0	--	--	--	--
rs138995227^1,2		--	245013735(+)	`TCACCC/TTCATG`	2	--	ut3¹		0	--	--	--	--
rs112842127^1,2	C	--	245013774(+)	`GTGCC-/CACACCC`	2	--	ut3¹		1		CSA	2
rs111230124^1,2	C	--	245013777(+)	`CCCACC/ACCCCC`	2	--	ut3¹		1		CSA	1

HapMap Linkage Disequilibrium report for HNRNPU (245013602 - 245027844 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for HNRNPU
5 CNVs: 74966 84954 74967 84955 84956
Human Gene Mutation Database (HGMD): HNRNPU

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HNRNPU

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HNRNPU for disorders           About GeneDecksing

OMIM gene information: 602869    OMIM disorders: --

20/21 diseases for HNRNPU (see all 21):    About MalaCards

treacher collins syndrome corpus callosum phlyctenulosis x inactivation

mouth disease intestinal tuberculosis diffuse gastric cancer gastric cancer

tuberculosis hepatocellular carcinoma seizures thyroid cancer

thyroiditis lung cancer prostate cancer adenoma

leukemia prostatitis schizophrenia carcinoma

4 Novoseek disease relationships for HNRNPU gene About this table

Disease	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	3	11259850 (1)
necrosis	5	9405365 (1), 11455567 (1), 11259850 (1)
tumors	8	18772145 (1), 12665652 (1), 20093774 (1), 8444314 (1) (see all 6)
cancer	1	12188916 (1)

Export disorders for HNRNPU gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HNRNPU gene, integrated from 9 sources (see all 168):
(articles sorted by number of sources associating them with HNRNPU)

Utopia: connect your pdf to the dynamic
world of online information

hnRNP-U/SAF-A is encoded by two differentially polyadenylated mRNAs in human cells. (PubMed id 7509195)^{1, 2, 3, 9} Fackelmayer F.O. and Richter A. (1994)
Purification of two isoforms of hnRNP-U and characterization of their nucleic acid binding activity. (PubMed id 8068679)^{1, 2, 3, 9} Fackelmayer F.O. and Richter A. (1994)
Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins. (PubMed id 7993898)^{1, 2, 9} Jordan P.... Kubler D. (1994)
Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box. (PubMed id 1628625)^{1, 2, 9} Kiledjian M. and Dreyfuss G. (1992)
Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. (PubMed id 19029303)^{1, 2} Weidensdorfer D....HA1ttelmaier S. (2009)
Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)^{1, 2} Joeson L.... Nielsen F.C. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3192	HGNC: 5048	AceView: HNRPU	Ensembl:ENSG00000153187	euGenes: HUgn3192
ECgene: HNRNPU	Kegg: 3192	H-InvDB: HNRNPU

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HNRNPU	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HNRNPU gene
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Patent Information for HNRNPU gene:
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