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HNRNPU Gene

protein-coding   GIFtS: 59
GCID: GC01M245013

Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment...


(Previous symbol: HNRPU)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor
A)1 2
     pp1202 3
HNRPU1 2 3     Heterogeneous Nuclear Ribonucleoprotein U2
Scaffold Attachment Factor A2 3     P120 Nuclear Protein2
SAF-A2 3     SAFA3
U21.12 3     p1203
HnRNP U2 3     

External Ids:    HGNC: 50481   Entrez Gene: 31922   Ensembl: ENSG000001531877   OMIM: 6028695   UniProtKB: Q008393   

Export aliases for HNRNPU gene to outside databases

Previous GC identifers: GC01M243081 GC01M215396


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPU Gene:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These
proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other
aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to
shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.
The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific
bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large
ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage
occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein
from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA
metabolism. At least two alternatively spliced transcript variants have been identified for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for HNRNPU Gene:
HNRNPU (heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)) is a protein-coding gene. Diseases associated with HNRNPU include phlyctenulosis, and intestinal tuberculosis. GO annotations related to this gene include RNA binding. An important paralog of this gene is HNRNPUL1.

UniProtKB/Swiss-Prot: HNRPU_HUMAN, Q00839
Function: Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high
affinity for scaffold-attached region (SAR) DNA. Binds to double- and single-stranded DNA and RNA

Gene Wiki entry for HNRNPU (HNRPU) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPU gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRNPU promoter sequence
   Search Chromatin IP Primers for HNRNPU

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

HNRNPU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPU gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M245013:  view genomic region     (about GC identifiers)

Start:
245,013,602 bp from pter      End:
245,027,844 bp from pter
Size:
14,243 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HNRPU_HUMAN, Q00839 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein U  
Size: 825 amino acids; 90584 Da
Subunit: Identified in the spliceosome C complex. Component of the coding region determinant (CRD)-mediated
complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a IGF2BP1-dependent mRNP granule
complex containing untranslated mRNAs. Interacts with IGF2BP1, IGF2BP2, IGF2BP3 and ERBB4. Ligand for CR2
Sequence caution: Sequence=AAC19382.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
1 PDB 3D structure from and Proteopedia for HNRNPU:
1ZRJ (3D)    
Secondary accessions: O75507 Q8N174 Q96HY9 Q9BQ09
Alternative splicing: 2 isoforms:  Q00839-1   Q00839-2   (Contains a N6-acetyllysine at position 215)

Explore the universe of human proteins at neXtProt for HNRNPU: NX_Q00839

Explore proteomics data for HNRNPU at MOPED

Post-translational modifications: 

  • Extensively phosphorylated1
  • Arg-733 and Arg-739 are dimethylated, probably to asymmetric dimethylarginine1
  • Citrullinated by PADI4 (By similarity)1
  • Ubiquitination2 at Lys9, Lys186, Lys265, Lys352, Lys464, Lys516, Lys524, Lys536, Lys544, Lys551,
                                 Lys565, Lys602, Lys635, Lys664, Lys814
  • Modification sites at PhosphoSitePlus

  • See HNRNPU Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004492.2  NP_114032.2  

    ENSEMBL proteins: 
     ENSP00000393151   ENSP00000283179   ENSP00000410728  
    Reactome Protein details: Q00839

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR001870 B30.2/SPRY
     IPR026745 hnRNP_U
     IPR027417 P-loop_NTPase
     IPR003877 SPRY_rcpt
     IPR003034 SAP_dom

    Graphical View of Domain Structure for InterPro Entry Q00839

    ProtoNet protein and cluster: Q00839

    1 Blocks protein domain: IPB003034 DNA-binding SAP

    UniProtKB/Swiss-Prot: HNRPU_HUMAN, Q00839
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 SAP domain


    HNRNPU for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRPU_HUMAN, Q00839
    Function: Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high
    affinity for scaffold-attached region (SAR) DNA. Binds to double- and single-stranded DNA and RNA

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding TAS1628625
    GO:0005515protein binding IPI17289661
    GO:0005524ATP binding IEA--
         
    HNRNPU for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for HNRNPU:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased influenza A virus in 
     Decreased viability  Increased S DNA content  Increased gamma-H2AX phosphory  S arrest 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hnrnpu):
     embryogenesis  growth/size/body  mortality/aging 

    HNRNPU for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HNRNPU
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    miRNA
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    miRTarBase miRNAs that target HNRNPU:
    hsa-mir-17-5p (MIRT050837), hsa-mir-149-5p (MIRT045483), hsa-mir-615-3p (MIRT039706), hsa-mir-27b-3p (MIRT046200), hsa-mir-1 (MIRT005282), hsa-mir-30c-5p (MIRT047974), hsa-mir-186-5p (MIRT045256), hsa-mir-7-5p (MIRT025868), hsa-mir-26a-5p (MIRT050141)

    Block miRNA regulation of human, mouse, rat HNRNPU using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPU (see all 159):
    hsa-miR-517a hsa-miR-877* hsa-miR-637 hsa-miR-298 hsa-miR-1243 hsa-miR-200b hsa-miR-642b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): HNRNPU 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPU

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPU


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HNRPU_HUMAN, Q00839: Nucleus. Cytoplasm. Cell surface. Note=Localized in cytoplasmic mRNP granules containing
    untranslated mRNAs. Component of ribonucleosomes. Also found associated with the cell surface
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    cytosol2
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0009986cell surface IEA--
    GO:0030529ribonucleoprotein complex IDA17289661
    GO:0070937CRD-mediated mRNA stability complex IDA19029303

    HNRNPU for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPU About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HNRNPU
        mRNA processing

    2 Reactome Pathways for HNRNPU
        mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA


    1 Kegg Pathway  (Kegg details for HNRNPU):
        Spliceosome


    HNRNPU for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPU
    Interactions:

        GeneGlobe Interaction Network for HNRNPU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPU (Q008391, 2, 3 ENSP000002831794) via UniProtKB, MINT, STRING, and/or I2D (see all 1063)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-18162 MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370083
    RUVBL2Q9Y2302, 3, ENSP000002214134MINT-7945693 MINT-6489355 MINT-7947479 I2D: score=1 STRING: ENSP00000221413
    HNRNPH1P319432, 3, ENSP000003491684MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349168
    RBM39Q144982, 3, ENSP000002533634MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000253363
    SNW1Q135732, 3, ENSP000002615314MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000261531
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006396RNA processing TAS1628625
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--
    GO:0070934CRD-mediated mRNA stabilization IMP19029303

    HNRNPU for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPU (HNRPU)

    3 Novoseek inferred chemical compound relationships for HNRNPU gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 36.4 12 9642150 (2), 10356358 (2), 7515933 (1), 1725602 (1) (see all 8)
    phosphotyrosine 28.8 1 7512571 (1)
    heparin 0 1 8444314 (1)



    HNRNPU for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HNRNPU gene (2 alternative transcripts): 
    NM_004501.3  NM_031844.2  

    Unigene Cluster for HNRNPU:

    Heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
    Hs.106212  [show with all ESTs]
    Unigene Representative Sequence: NM_031844
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444376(uc001iay.1 uc001iaz.1 uc001iba.1) ENST00000283179
    ENST00000366525 ENST00000483966 ENST00000468690 ENST00000440865 ENST00000465881
    ENST00000476241
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    hsa-miR-517a hsa-miR-877* hsa-miR-637 hsa-miR-298 hsa-miR-1243 hsa-miR-200b hsa-miR-642b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): HNRNPU 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPU
      QuantiFast Probe-based Assays in human, mouse, rat HNRNPU

    Additional mRNA sequence: 

    AF068846.1 AF461014.1 AK095525.1 AK126868.1 AK130669.1 AK297119.1 AK307661.1 BC003367.1 
    BC003621.2 BC007950.2 BC015782.1 BC024767.1 BC034925.1 X65488.1 

    Selected DOTS entries (see all 50):

    DT.75162681  DT.208604  DT.95299838  DT.97781188  DT.100683711  DT.100683712  DT.100771204  DT.95225869 
    DT.121445578  DT.91997642  DT.95298275  DT.100683700  DT.92465883  DT.102842768  DT.121445599  DT.95299795 
    DT.121445611  DT.95299851  DT.87079962  DT.100848272  DT.85103493  DT.100683714  DT.121445689  DT.92465880 

    Selected AceView cDNA sequences (see all 1297):

    BM720921 BC024767 AI692217 BI870169 BM760164 BU678172 BF797994 N87078 
    AW276546 BG620832 N24746 BM752008 BM992188 AA367043 AL557228 BG231988 
    CR608250 AA402247 BU631294 BF980876 AA187968 CA313116 AI367963 CB216786 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPU (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                    -     -                 -                                                     -                 -                                 
    SP2:                          -                 -                                                     -                 -                                 
    SP3:                    -     -     -           -                                                                                                         
    SP4:                                            -                                                                                                         
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for HNRNPU

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HNRNPU expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HNRNPU Expression
    About this image


    HNRNPU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    HNRNPU Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPU Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.106212
        Custom PCR Arrays for HNRNPU
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HNRNPU gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpu1 , 5 heterogeneous nuclear ribonucleoprotein U1, 5 92.03(n)1
    96.87(a)1
      1 (83.16 cM)5
    518101  NM_016805.21  NP_058085.21 
     1783230745 
    chicken
    (Gallus gallus)
    Aves HNRNPU1 heterogeneous nuclear ribonucleoprotein U (scaffold more 85.46(n)
    93.72(a)
      421492  XM_419539.4  XP_419539.4 
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPU6
    heterogeneous nuclear ribonucleoprotein U (scaffol...
    74(a)
    1 ↔ 1
    GL343285.1(1230116-1242461)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.89512 Xenopus laevis scaffold attachment factor A (Saf-A) more 82.26(n)    AF068847.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hnrnpub1 heterogeneous nuclear ribonucleoprotein Ub 65.34(n)
    65.85(a)
      334490  NM_001033595.2  NP_001028767.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG301226
    --
    17(a)
    1 → many
    2R(14519833-14526773)
    worm
    (Caenorhabditis elegans)
    Secernentea Y41E3.116
    Protein Y41E3.11, isoform a
    8(a)
    1 → many
    IV(15040075-15049283) WBGene00012769


    ENSEMBL Gene Tree for HNRNPU (if available)
    TreeFam Gene Tree for HNRNPU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPU gene
    HNRNPUL12  HNRNPUL22  HNRNPUL2-BSCL22  
    4 SIMAP similar genes for HNRNPU using alignment to 2 protein entries:     HNRPU_HUMAN (see all proteins):
    HNRPU    HNRNPUL1    HNRNPUL2-BSCL2    HNRNPUL2

    HNRNPU for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HNRNPU
    PGOHUM00000248152


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPU (see all 383)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506333181,2
    C--245013111(+) ATATC-/CATTA 
     TGAATAA
    CATTA
    2 -- cds10--------
    rs1998021081,2
    C--245013111(+) AATATA/CCNNNN 2 -- ds50010--------
    rs1829774591,2
    C--245013141(+) ACCCAC/TCTATC 2 -- ds50010--------
    rs1427626571,2
    C--245013318(+) AGACTC/GTGCTA 2 -- ds50010--------
    rs125646421,2
    C,F,H--245013357(+) TGTGAC/TGCCAA 2 -- ds50016Minor allele frequency- T:0.03NS EA NA 540
    rs1488449461,2
    C--245013549(+) TAATT-/AACAAGTT 2 -- ds50010--------
    rs1460612261,2
    --245013568(+) CAAAGA/GTTAGT 2 -- ds50010--------
    rs1389952271,2
    C--245013735(+) TCACCC/TTCATG 2 -- ut310--------
    rs572292491,2
    C--245013777(+) CCCAC-/A/ACC 
            
    CCCCC
    4 -- ut311NA 2
    rs1112301241,2
    C--245013777(+) CCCACC/ACCCCC 2 -- ut311Minor allele frequency- A:0.00CSA 1

    HapMap Linkage Disequilibrium report for HNRNPU (245013602 - 245027844 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HNRNPU: --
    Human Gene Mutation Database (HGMD): HNRNPU
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPU
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPU

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602869    OMIM disorders: --

    Selected diseases for HNRNPU (see all 24):    
    About MalaCards
    phlyctenulosis    intestinal tuberculosis    diffuse gastric cancer    mouth disease
    treacher collins syndrome    intellectual disability    tuberculosis    thyroid cancer
    thyroiditis    adenoma    tonsillitis    hiv-1
    parkinson's disease    schizophrenia    lung cancer    hepatocellular carcinoma
    prostate cancer    prostatitis    leukemia    multiple myeloma


    HNRNPU for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for HNRNPU gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 0 3 11259850 (1)
    necrosis 0 5 9405365 (1), 11455567 (1), 11259850 (1)
    tumors 0 8 18772145 (1), 12665652 (1), 20093774 (1), 8444314 (1) (see all 6)
    cancer 0 1 12188916 (1)

    Genetic Association Database (GAD): HNRNPU

    Export disorders for HNRNPU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPU gene, integrated from 10 sources (see all 198):
    (articles sorted by number of sources associating them with HNRNPU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hnRNP-U/SAF-A is encoded by two differentially polyadenylated mRNAs in human cells. (PubMed id 7509195)1, 2, 3, 9 Fackelmayer F.O. and Richter A. (Biochim. Biophys. Acta 1994)
    2. Purification of two isoforms of hnRNP-U and characterization of their nucleic acid binding activity. (PubMed id 8068679)1, 2, 3, 9 Fackelmayer F.O. and Richter A. (Biochemistry 1994)
    3. Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins. (PubMed id 7993898)1, 2, 9 Jordan P.... Kubler D. (Biochemistry 1994)
    4. Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box. (PubMed id 1628625)1, 2, 9 Kiledjian M. and Dreyfuss G. (EMBO J. 1992)
    5. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. (PubMed id 19029303)1, 2 Weidensdorfer D.... Huettelmaiery S. (RNA 2009)
    6. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3192 HGNC: 5048 AceView: HNRPU Ensembl:ENSG00000153187 euGenes: HUgn3192
    ECgene: HNRNPU Kegg: 3192 H-InvDB: HNRNPU

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HNRNPU Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPU gene:
    Search GeneIP for patents involving HNRNPU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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