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Aliases for HNRNPR Gene

Aliases for HNRNPR Gene

  • Heterogeneous Nuclear Ribonucleoprotein R 2 3
  • HNRPR 3 4
  • HnRNP-R 3
  • HnRNP R 4
  • HNRPR, 6

External Ids for HNRNPR Gene

Previous HGNC Symbols for HNRNPR Gene

  • HNRPR

Previous GeneCards Identifiers for HNRNPR Gene

  • GC01M023509
  • GC01M023630
  • GC01M021888

Summaries for HNRNPR Gene

Entrez Gene Summary for HNRNPR Gene

  • This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]

GeneCards Summary for HNRNPR Gene

HNRNPR (Heterogeneous Nuclear Ribonucleoprotein R) is a Protein Coding gene. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBM47.

UniProtKB/Swiss-Prot for HNRNPR Gene

  • Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus

Gene Wiki entry for HNRNPR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPR Gene

Genomics for HNRNPR Gene

Regulatory Elements for HNRNPR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HNRNPR Gene

Start:
23,303,771 bp from pter
End:
23,344,650 bp from pter
Size:
40,880 bases
Orientation:
Minus strand

Genomic View for HNRNPR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPR Gene

Proteins for HNRNPR Gene

  • Protein details for HNRNPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43390-HNRPR_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein R
    Protein Accession:
    O43390
    Secondary Accessions:
    • Q2L7G6
    • Q5TEH1
    • Q9BV64
    • S4R3J4

    Protein attributes for HNRNPR Gene

    Size:
    633 amino acids
    Molecular mass:
    70943 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with GTPBP1.

    Three dimensional structures from OCA and Proteopedia for HNRNPR Gene

    Alternative splice isoforms for HNRNPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPR Gene

Proteomics data for HNRNPR Gene at MOPED

Post-translational modifications for HNRNPR Gene

  • Ubiquitination at Lys41, Lys187, Lys359, and Lys366
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HNRNPR (hnRNP R)

No data available for DME Specific Peptides for HNRNPR Gene

Domains for HNRNPR Gene

Gene Families for HNRNPR Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for HNRNPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43390

UniProtKB/Swiss-Prot:

HNRPR_HUMAN :
  • O43390
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPR: view

Function for HNRNPR Gene

Molecular function for HNRNPR Gene

UniProtKB/Swiss-Prot Function: Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus

Gene Ontology (GO) - Molecular Function for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 9421497
GO:0005515 protein binding IPI 16169070
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HNRNPR: view

Phenotypes for HNRNPR Gene

GenomeRNAi human phenotypes for HNRNPR:
genes like me logo Genes that share phenotypes with HNRNPR: view

Animal Model Products

CRISPR Products

miRNA for HNRNPR Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPR Gene

Localization for HNRNPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPR Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPR Gene COMPARTMENTS Subcellular localization image for HNRNPR gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex NAS 9421497
GO:0005730 NOT nucleolus IDA 9421497
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HNRNPR: view

Pathways for HNRNPR Gene

genes like me logo Genes that share pathways with HNRNPR: view

Pathways by source for HNRNPR Gene

1 Cell Signaling Technology pathway for HNRNPR Gene
1 BioSystems pathway for HNRNPR Gene

Gene Ontology (GO) - Biological Process for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing NAS 9421497
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with HNRNPR: view

Transcripts for HNRNPR Gene

Unigene Clusters for HNRNPR Gene

Heterogeneous nuclear ribonucleoprotein R:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPR

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HNRNPR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPR Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: - - - -
SP11: - - - -
SP12:
SP13:

Relevant External Links for HNRNPR Gene

GeneLoc Exon Structure for
HNRNPR
ECgene alternative splicing isoforms for
HNRNPR

Expression for HNRNPR Gene

mRNA expression in normal human tissues for HNRNPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPR Gene

SOURCE GeneReport for Unigene cluster for HNRNPR Gene Hs.373763

genes like me logo Genes that share expressions with HNRNPR: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPR Gene

Orthologs for HNRNPR Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPR 35
  • 99.89 (n)
  • 100 (a)
HNRNPR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HNRNPR 35
  • 96.31 (n)
  • 99.84 (a)
HNRNPR 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPR 35
  • 97.21 (n)
  • 100 (a)
HNRNPR 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpr 35
  • 91.46 (n)
  • 95.89 (a)
Hnrnpr 16
Hnrnpr 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPR 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPR 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnpr 35
  • 91.98 (n)
  • 95.73 (a)
chicken
(Gallus gallus)
Aves HNRNPR 35
  • 85.81 (n)
  • 93.2 (a)
HNRNPR 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPR 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6623 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpr 35
  • 75.27 (n)
  • 84.18 (a)
Str.10730 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12332 35
zebrafish
(Danio rerio)
Actinopterygii hnrnpr 36
  • 79 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17838 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-2 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for HNRNPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPR Gene

ENSEMBL:
Gene Tree for HNRNPR (if available)
TreeFam:
Gene Tree for HNRNPR (if available)

Paralogs for HNRNPR Gene

Paralogs for HNRNPR Gene

Selected SIMAP similar genes for HNRNPR Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for HNRNPR Gene

genes like me logo Genes that share paralogs with HNRNPR: view

Variants for HNRNPR Gene

Sequence variations from dbSNP and Humsavar for HNRNPR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs581834 -- 23,311,896(+) TACTT(C/T)GCTTG intron-variant
rs582557 -- 23,312,760(+) CCACC(A/G)ACCAA intron-variant
rs585180 -- 23,312,651(+) AAGCC(A/G)ATTAA intron-variant
rs588316 -- 23,306,060(+) GTTAA(C/T)CTATC utr-variant-3-prime
rs593246 -- 23,325,268(+) AAAAA(C/T)AGCTG intron-variant

Relevant External Links for HNRNPR Gene

HapMap Linkage Disequilibrium report
HNRNPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HNRNPR Gene

Disorders for HNRNPR Gene

(1) University of Copenhagen DISEASES for HNRNPR Gene

genes like me logo Genes that share disorders with HNRNPR: view

No data available for UniProtKB/Swiss-Prot for HNRNPR Gene

Publications for HNRNPR Gene

  1. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. (PMID: 9421497) Hassfeld W. … Tan E.M. (Nucleic Acids Res. 1998) 2 3 4 23
  2. Cloning and expression of a novel isoform of heterogeneous nuclear ribonucleoprotein-R. (PMID: 15858414) Huang J. … Xu P. (NeuroReport 2005) 3 4 23
  3. Heterogeneous nuclear ribonucleoprotein R enhances transcription from the naturally configured c-fos promoter in vitro. (PMID: 19581295) Fukuda A. … Hisatake K. (J. Biol. Chem. 2009) 3 23
  4. The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons. (PMID: 20167579) Glinka M. … Sendtner M. (Hum. Mol. Genet. 2010) 3 23
  5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4

Products for HNRNPR Gene

Sources for HNRNPR Gene

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