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HNRNPR Gene

protein-coding   GIFtS: 56
GCID: GC01M023630

Heterogeneous Nuclear Ribonucleoprotein R


(Previous symbol: HNRPR)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein R1 2
HNRPR1 2 3 5
HnRNP R2 3
hnRNP-R2

External Ids:    HGNC: 50471   Entrez Gene: 102362   Ensembl: ENSG000001259447   OMIM: 6072015   UniProtKB: O433903   

Export aliases for HNRNPR gene to outside databases

Previous GC identifers: GC01M023509 GC01M021888


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPR Gene:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are
associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA
metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the
nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded
by this gene has three repeats of quasi-RRM domains that bind to RNAs and also contains a nuclear localization
motif. Multiple alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for HNRNPR Gene:
HNRNPR (heterogeneous nuclear ribonucleoprotein R) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SYNCRIP.

UniProtKB/Swiss-Prot: HNRPR_HUMAN, O43390
Function: Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear
ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus

Gene Wiki entry for HNRNPR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPR gene promoter:
         GR   USF1   GR-beta   USF-1:USF-2   Nkx2-5   SRY   POU2F1   POU2F1a   GR-alpha   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HNRNPR promoter sequence
   Search Chromatin IP Primers for HNRNPR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.12

HNRNPR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M023630:  view genomic region     (about GC identifiers)

Start:
23,630,264 bp from pter      End:
23,670,853 bp from pter
Size:
40,590 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HNRPR_HUMAN, O43390 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein R  
Size: 633 amino acids; 70943 Da
Subunit: Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex
containing untranslated mRNAs. Interacts with GTPBP1
1 PDB 3D structure from and Proteopedia for HNRNPR:
2DK2 (3D)    
Secondary accessions: Q2L7G6 Q5TEH1 Q9BV64
Alternative splicing: 3 isoforms:  O43390-1   O43390-2   O43390-3   (Expression is low and neural-specific)

Explore the universe of human proteins at neXtProt for HNRNPR: NX_O43390

Explore proteomics data for HNRNPR at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys41, Lys187, Lys359, Lys366
  • Modification sites at PhosphoSitePlus

  • See HNRNPR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001095867.1  NP_001095868.1  NP_001095869.1  NP_005817.1  

    ENSEMBL proteins: 
     ENSP00000474437   ENSP00000363745   ENSP00000363741   ENSP00000304405   ENSP00000475760  
     ENSP00000392799   ENSP00000415042  
    Reactome Protein details: O43390

    HNRNPR Human Recombinant Protein Products:

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    antibodies-online peptides for HNRNPR

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR006535 HnRNP_R/Q_splicing_fac
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O43390

    ProtoNet protein and cluster: O43390

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: HNRPR_HUMAN, O43390
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    Find genes that share domains with HNRNPR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRPR_HUMAN, O43390
    Function: Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear
    ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding NAS9421497
    GO:0005515protein binding IPI17474147
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with HNRNPR           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HNRNPR:
     Decreased circadian period len 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HNRNPR

    miRNA
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    miRTarBase miRNAs that target HNRNPR:
    hsa-mir-615-3p (MIRT040144), hsa-mir-18a-5p (MIRT031331), hsa-mir-130b-5p (MIRT038314), hsa-mir-940 (MIRT036632)

    Block miRNA regulation of human, mouse, rat HNRNPR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPR (see all 17):
    hsa-miR-2052 hsa-miR-498 hsa-miR-4307 hsa-miR-300 hsa-miR-606 hsa-miR-641 hsa-miR-7-1* hsa-miR-2276
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPR 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HNRPR_HUMAN, O43390: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing
    untranslated mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex NAS9421497
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with HNRNPR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPR About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Translational Control
    Translational Control


    Find genes that share SuperPaths with HNRNPR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HNRNPR
        Translational Control

    1 BioSystems Pathway for HNRNPR
        mRNA processing


    2 Reactome Pathways for HNRNPR
        mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPR
    Interactions:

        Search GeneGlobe Interaction Network for HNRNPR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPR (O433901, 2, 3 ENSP000003637454) via UniProtKB, MINT, STRING, and/or I2D (see all 736)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 I2D: score=3 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7945693 I2D: score=3 STRING: ENSP00000370119
    FARSAQ9Y2852, 3, ENSP000003203094MINT-65368 I2D: score=4 STRING: ENSP00000320309
    RPL26P612542, 3, ENSP000002938424MINT-65366 I2D: score=4 STRING: ENSP00000293842
    ABL1P005192, 3, ENSP000003614234MINT-8110455 I2D: score=3 STRING: ENSP00000361423
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing NAS9421497
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with HNRNPR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPR (HNRPR)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HNRNPR gene (4 alternative transcripts): 
    NM_001102397.1  NM_001102398.1  NM_001102399.1  NM_005826.3  

    Unigene Cluster for HNRNPR:

    Heterogeneous nuclear ribonucleoprotein R
    Hs.373763  [show with all ESTs]
    Unigene Representative Sequence: BX647784
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464516 ENST00000478691(uc001bgs.4 uc009vqk.3 uc010odx.2 uc009vql.3)
    ENST00000374616(uc001bgp.4) ENST00000476660(uc001bgo.3) ENST00000374612(uc001bgr.4 uc010odw.2)
    ENST00000302271 ENST00000606561 ENST00000463552 ENST00000470941 ENST00000476451
    ENST00000490652 ENST00000427764 ENST00000426846
    miRNA
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    hsa-miR-2052 hsa-miR-498 hsa-miR-4307 hsa-miR-300 hsa-miR-606 hsa-miR-641 hsa-miR-7-1* hsa-miR-2276
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPR 3' UTR sequence
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    Additional mRNA sequence: 

    AF000364.1 AK001846.1 AK098580.1 AK297382.1 AK297405.1 AK300029.1 AK311519.1 AK313142.1 
    BC001449.2 BC110389.1 BX538163.1 BX640912.1 BX647784.1 DQ351905.1 

    Selected DOTS entries (see all 28):

    DT.309325  DT.100826223  DT.100826229  DT.95184997  DT.451851  DT.91946687  DT.100668861  DT.100826231 
    DT.95263190  DT.91766504  DT.121354628  DT.121354569  DT.75138084  DT.91766495  DT.100773054  DT.121354563 
    DT.121354541  DT.121354542  DT.91766498  DT.101961283  DT.121354553  DT.121354559  DT.121354562  DT.121354614 

    Selected AceView cDNA sequences (see all 569):

    AU123385 BE888103 BE408810 BE251227 BX441367 BG259904 AA486402 BU615375 
    AA379170 CK820933 BM970219 BU175143 CA443396 CB132129 AL557253 BU621279 
    AW160414 BM786272 CN480593 R33042 NM_005826 BM710382 AI225142 BU552860 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPR (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                                -                             -     -           -                             -                                 
    SP2:                                -                             -     -                                         -                                 
    SP3:              -                 -                             -     -                                         -                                 
    SP4:              -                 -                             -     -           -                                                               
    SP5:              -                 -                 -           -     -           -                                                               


    ECgene alternative splicing isoforms for HNRNPR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGATTTCA
    HNRNPR Expression
    About this image


    HNRNPR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    HNRNPR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.373763
        Custom PCR Arrays for HNRNPR
    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HNRNPR gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpr1 , 5 heterogeneous nuclear ribonucleoprotein R1, 5 91.46(n)1
    95.89(a)1
      4 (68.40 cM)5
    743261  NM_001277121.11  NP_001264050.11 
     1363109425 
    chicken
    (Gallus gallus)
    Aves HNRNPR1 heterogeneous nuclear ribonucleoprotein R 85.81(n)
    93.2(a)
      419570  NM_001006309.3  NP_001006309.3 
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPR6
    heterogeneous nuclear ribonucleoprotein R
    93(a)
    1 ↔ 1
    GL343743.1(182374-204980)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.66232 Xenopus laevis transcribed sequence with strong similarity more 79.6(n)    BQ734736.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hnrnpr6
    heterogeneous nuclear ribonucleoprotein R
    79(a)
    many ↔ many
    19(40444-48614) ENSDARG00000014569
    fruit fly
    (Drosophila melanogaster)
    Insecta CG178386
    --
    46(a)
    1 → many
    3R(16582451-16631963)
    worm
    (Caenorhabditis elegans)
    Secernentea hrp-26
    Protein HRP-2, isoform a (hrp-2) mRNA, complete cd...
    41(a)
    1 → many
    I(12060276-12064897) WBGene00002000


    ENSEMBL Gene Tree for HNRNPR (if available)
    TreeFam Gene Tree for HNRNPR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPR gene
    SYNCRIP2  RBM472  DND12  RBM462  A1CF2  
    7 SIMAP similar genes for HNRNPR using alignment to 4 protein entries:     HNRPR_HUMAN (see all proteins):
    DKFZp686O0665    HNRPR    DKFZp686A13234    SYNCRIP    A1CF    RBM46
    RBM47

    Find genes that share paralogs with HNRNPR           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for HNRNPR
    PGOHUM00000251234 PGOHUM00000242200 PGOHUM00000245880


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPR (see all 735)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710204991,2
    C--21915184(+) AAAAA-/A/    
       AAAAA
    TTAGC
    4 -- int11NA 2
    rs1485766261,2
    --23635845(+) CAATTC/TTCCCT 4 -- ds50010--------
    rs127565971,2
    C--23635986(+) ATGCCT/GGCAAG 4 -- ds50011Minor allele frequency- G:0.00NA 2
    rs38354211,2
    C--23636016(-) AAAAA-/A/AA  
            
    CAGGT
    4 -- ds50010--------
    rs561965961,2
    C--23636028(+) TTTTT-/TAATAA 4 -- ds50011Minor allele frequency- T:0.00NA 2
    rs1844444101,2
    --23636033(+) TAATAA/GAAGAT 4 -- ds50010--------
    rs1891463771,2
    --23636064(+) GACTAC/TGAGAG 4 -- ds50010--------
    rs10450791,2
    C,F,H--23636094(-) TTCCAA/GTTAGC 4 -- ds500113Minor allele frequency- G:0.12NS EA NA WA 1350
    rs1389190091,2
    C--23636146(+) AACAC-/ATGTTGG 4 -- ds50010--------
    rs560976601,2
    C--23636349(+) CATCAA/GAGAAC 4 -- ut310--------

    HapMap Linkage Disequilibrium report for HNRNPR (23630264 - 23670853 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HNRNPR: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPR
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607201    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for HNRNPR:
    Spinal muscular atrophy

    Find genes that share disorders with HNRNPR           About GenesLikeMe


    Export disorders for HNRNPR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPR gene, integrated from 10 sources (see all 73):
    (articles sorted by number of sources associating them with HNRNPR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. (PubMed id 9421497)1, 2, 3, 9 Hassfeld W.... Tan E.M. (Nucleic Acids Res. 1998)
    2. Cloning and expression of a novel isoform of heterogeneous nuclear ribonucleoprotein-R. (PubMed id 15858414)1, 2, 9 Huang J.... Xu P. (NeuroReport 2005)
    3. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    6. Heterogeneous nuclear ribonucleoprotein R enhances transcription from the naturally configured c-fos promoter in vitro. (PubMed id 19581295)1, 9 Fukuda A....Hisatake K. (J. Biol. Chem. 2009)
    7. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    8. The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. (PubMed id 23658844)1 Lockwood W.W....Beverly L.J. (PLoS ONE 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10236 HGNC: 5047 AceView: HNRPR Ensembl:ENSG00000125944 euGenes: HUgn10236
    ECgene: HNRNPR H-InvDB: HNRNPR

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HNRNPR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPR gene:
    Search GeneIP for patents involving HNRNPR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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