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Aliases for HNRNPR Gene

Aliases for HNRNPR Gene

  • Heterogeneous Nuclear Ribonucleoprotein R 2 3 5
  • HNRPR 3 4
  • HnRNP-R 3
  • HnRNP R 4

External Ids for HNRNPR Gene

Previous HGNC Symbols for HNRNPR Gene


Previous GeneCards Identifiers for HNRNPR Gene

  • GC01M023509
  • GC01M023630
  • GC01M021888

Summaries for HNRNPR Gene

Entrez Gene Summary for HNRNPR Gene

  • This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]

GeneCards Summary for HNRNPR Gene

HNRNPR (Heterogeneous Nuclear Ribonucleoprotein R) is a Protein Coding gene. Diseases associated with HNRNPR include Spinal Muscular Atrophy. Among its related pathways are Translational Control and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SYNCRIP.

UniProtKB/Swiss-Prot for HNRNPR Gene

  • Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

Gene Wiki entry for HNRNPR Gene

Additional gene information for HNRNPR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPR Gene

Genomics for HNRNPR Gene

Regulatory Elements for HNRNPR Gene

Enhancers for HNRNPR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H023625 0.9 dbSUPER 51.8 -281.0 -281002 0.8 YBX3 HDGF PKNOX1 ATF1 TBL1XR1 ZNF473 ZNF195 NFXL1 YBX1 GLI4 ZNF436-AS1 HNRNPR SRSF10 LINC01355 KDM1A PNRC2 RPL11 MDS2 ID3 E2F2
GH01H023691 1.1 ENCODE 37.5 -348.0 -347973 3.1 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SRSF10 SRRM1 LINC01355 HNRNPR PNRC2 KDM1A RPL11 ELOA ASAP3 GC01M023708
GH01H023539 1.6 Ensembl ENCODE dbSUPER 23.4 -195.3 -195340 1.1 HDGF PKNOX1 ARNT ARID4B SLC30A9 ZNF766 ZNF143 ZNF207 ZC3H11A REST LINC01355 SRSF10 HNRNPR ZNF436-AS1 KDM1A ELOA E2F2 LOC105376859
GH01H023166 1.3 ENCODE dbSUPER 22.4 +176.3 176313 4.5 HDGF PKNOX1 ARID4B SIN3A FEZF1 YY1 ZNF548 SP3 REST ZNF592 SRSF10 ZBTB40 PNRC2 RPL11 LINC01355 HNRNPR ELOA LUZP1 LACTBL1 GC01P023167
GH01H023521 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15 -184.0 -184034 13.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 CBX5 LINC01355 SRSF10 KDM1A HNRNPR ASAP3 ID3 ZNF436 TCEA3 PNRC2 ENSG00000271420
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HNRNPR on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for HNRNPR Gene

Genomic Locations for HNRNPR Gene
40,880 bases
Minus strand

Genomic View for HNRNPR Gene

Genes around HNRNPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPR Gene

Proteins for HNRNPR Gene

  • Protein details for HNRNPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein R
    Protein Accession:
    Secondary Accessions:
    • Q2L7G6
    • Q5TEH1
    • Q9BV64
    • S4R3J4

    Protein attributes for HNRNPR Gene

    633 amino acids
    Molecular mass:
    70943 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with GTPBP1.

    Three dimensional structures from OCA and Proteopedia for HNRNPR Gene

    Alternative splice isoforms for HNRNPR Gene


neXtProt entry for HNRNPR Gene

Post-translational modifications for HNRNPR Gene

  • Ubiquitination at isoforms=2, 341, posLast=187187, and isoforms=2, 3, 4359
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPR Gene

Domains & Families for HNRNPR Gene

Gene Families for HNRNPR Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPR: view

No data available for UniProtKB/Swiss-Prot for HNRNPR Gene

Function for HNRNPR Gene

Molecular function for HNRNPR Gene

UniProtKB/Swiss-Prot Function:
Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

Phenotypes From GWAS Catalog for HNRNPR Gene

Gene Ontology (GO) - Molecular Function for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding NAS 9421497
GO:0003730 mRNA 3-UTR binding IEA --
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with HNRNPR: view

Phenotypes for HNRNPR Gene

genes like me logo Genes that share phenotypes with HNRNPR: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPR Gene

Localization for HNRNPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPR Gene

Nucleus. Microsome. Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). {ECO:0000250 UniProtKB:Q7TMK9, ECO:0000269 PubMed:17289661}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPR gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex NAS 9421497
GO:0005730 NOT nucleolus IDA 9421497
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HNRNPR: view

Pathways & Interactions for HNRNPR Gene

genes like me logo Genes that share pathways with HNRNPR: view

Pathways by source for HNRNPR Gene

1 Cell Signaling Technology pathway for HNRNPR Gene
1 BioSystems pathway for HNRNPR Gene

Gene Ontology (GO) - Biological Process for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing NAS 9421497
GO:0007623 circadian rhythm IEA --
GO:0008380 RNA splicing IEA --
GO:0016070 RNA metabolic process TAS --
genes like me logo Genes that share ontologies with HNRNPR: view

No data available for SIGNOR curated interactions for HNRNPR Gene

Drugs & Compounds for HNRNPR Gene

No Compound Related Data Available

Transcripts for HNRNPR Gene

Unigene Clusters for HNRNPR Gene

Heterogeneous nuclear ribonucleoprotein R:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPR Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: - - - -
SP11: - - - -

Relevant External Links for HNRNPR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HNRNPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPR Gene

Protein differential expression in normal tissues from HIPED for HNRNPR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.2) and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPR Gene

Protein tissue co-expression partners for HNRNPR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPR Gene:


SOURCE GeneReport for Unigene cluster for HNRNPR Gene:


Evidence on tissue expression from TISSUES for HNRNPR Gene

  • Nervous system(5)
  • Liver(4.5)
  • Eye(2.7)
  • Skin(2.5)
  • Spleen(2.4)
  • Heart(2.2)
  • Lung(2.2)
  • Kidney(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with HNRNPR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPR Gene

Orthologs for HNRNPR Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HNRNPR 33 34
  • 99.89 (n)
(Canis familiaris)
Mammalia HNRNPR 33 34
  • 97.21 (n)
(Bos Taurus)
Mammalia HNRNPR 33 34
  • 96.31 (n)
(Monodelphis domestica)
Mammalia HNRNPR 34
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia HNRNPR 34
  • 92 (a)
(Rattus norvegicus)
Mammalia Hnrnpr 33
  • 91.98 (n)
(Mus musculus)
Mammalia Hnrnpr 33 16 34
  • 91.46 (n)
(Gallus gallus)
Aves HNRNPR 33 34
  • 85.81 (n)
(Anolis carolinensis)
Reptilia HNRNPR 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpr 33
  • 75.27 (n)
Str.10730 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6623 33
(Danio rerio)
Actinopterygii hnrnpr 34
  • 79 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12332 33
fruit fly
(Drosophila melanogaster)
Insecta CG17838 34
  • 46 (a)
(Caenorhabditis elegans)
Secernentea hrp-2 34
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
Species where no ortholog for HNRNPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPR Gene

Gene Tree for HNRNPR (if available)
Gene Tree for HNRNPR (if available)

Paralogs for HNRNPR Gene

Paralogs for HNRNPR Gene

(7) SIMAP similar genes for HNRNPR Gene using alignment to 4 proteins: Pseudogenes for HNRNPR Gene

genes like me logo Genes that share paralogs with HNRNPR: view

Variants for HNRNPR Gene

Sequence variations from dbSNP and Humsavar for HNRNPR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000011953 -- 23,343,863(+) GAAGC(A/G)GCAGG intron-variant
rs1000020640 -- 23,337,257(+) AAGAG(C/T)ATGAA intron-variant
rs1000055644 -- 23,343,214(+) ATTTA(A/C)AGATT intron-variant
rs1000076889 -- 23,337,556(+) GGAGG(C/G)TGAGG intron-variant
rs1000119317 -- 23,324,018(+) TAAAA(A/G)CAGAA intron-variant

Variation tolerance for HNRNPR Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPR Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HNRNPR Gene

Disorders for HNRNPR Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNRNPR Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spinal muscular atrophy
  • juvenile spinal muscular atrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HNRNPR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HNRNPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPR Gene

Publications for HNRNPR Gene

  1. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. (PMID: 9421497) Hassfeld W … Tan EM (Nucleic acids research 1998) 2 3 4 22 60
  2. Cloning and expression of a novel isoform of heterogeneous nuclear ribonucleoprotein-R. (PMID: 15858414) Huang J … Xu P (Neuroreport 2005) 3 4 22 60
  3. The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons. (PMID: 20167579) Glinka M … Sendtner M (Human molecular genetics 2010) 3 22 60
  4. Heterogeneous nuclear ribonucleoprotein R enhances transcription from the naturally configured c-fos promoter in vitro. (PMID: 19581295) Fukuda A … Hisatake K (The Journal of biological chemistry 2009) 3 22 60
  5. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Jønson L … Nielsen FC (Molecular & cellular proteomics : MCP 2007) 3 4 60

Products for HNRNPR Gene

Sources for HNRNPR Gene

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