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Aliases for HNRNPR Gene

Aliases for HNRNPR Gene

  • Heterogeneous Nuclear Ribonucleoprotein R 2 3 5
  • HNRPR 3 4
  • HnRNP-R 3
  • HnRNP R 4

External Ids for HNRNPR Gene

Previous HGNC Symbols for HNRNPR Gene

  • HNRPR

Previous GeneCards Identifiers for HNRNPR Gene

  • GC01M023509
  • GC01M023630
  • GC01M021888

Summaries for HNRNPR Gene

Entrez Gene Summary for HNRNPR Gene

  • This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]

GeneCards Summary for HNRNPR Gene

HNRNPR (Heterogeneous Nuclear Ribonucleoprotein R) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Translational Control. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SYNCRIP.

UniProtKB/Swiss-Prot for HNRNPR Gene

  • Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

Gene Wiki entry for HNRNPR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPR Gene

Genomics for HNRNPR Gene

Regulatory Elements for HNRNPR Gene

Enhancers for HNRNPR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F023512 0.5 FANTOM5 2.2 -168.3 -168333 0.3 ZNF362 ZNF512 NFE2 YY1 ZNF436 ID3 ENSG00000201405 ZNF436-AS1 HNRNPR PIR36355 LOC101928163
GH01F023584 1.5 FANTOM5 Ensembl ENCODE 1.2 -249.6 -249635 18.7 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A ZNF766 ZNF143 FOS ZNF436-AS1 LINC01355 PNRC2 E2F2 ID3 ZNF436 ASAP3 ENSG00000201405 STPG1 RPL11
GH01F023339 0.6 ENCODE 0.8 +1.6 1647 6.3 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF436-AS1 ZNF436 ENSG00000201405 ELOA ZBTB40-IT1 TCEA3 HNRNPR LINC01355
GH01F023328 0.6 ENCODE 0.3 +15.8 15808 0.2 ZNF639 KLF1 ZNF146 POLR2A ZNF600 SUPT5H HNRNPR LINC01355
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HNRNPR on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000532537 1350 4201 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for HNRNPR Gene

Chromosome:
1
Start:
23,303,771 bp from pter
End:
23,344,650 bp from pter
Size:
40,880 bases
Orientation:
Minus strand

Genomic View for HNRNPR Gene

Genes around HNRNPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPR Gene

Proteins for HNRNPR Gene

  • Protein details for HNRNPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43390-HNRPR_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein R
    Protein Accession:
    O43390
    Secondary Accessions:
    • Q2L7G6
    • Q5TEH1
    • Q9BV64
    • S4R3J4

    Protein attributes for HNRNPR Gene

    Size:
    633 amino acids
    Molecular mass:
    70943 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with GTPBP1.

    Three dimensional structures from OCA and Proteopedia for HNRNPR Gene

    Alternative splice isoforms for HNRNPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPR Gene

Post-translational modifications for HNRNPR Gene

  • Ubiquitination at Lys 41, Lys 187, and Lys 359
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPR Gene

Domains & Families for HNRNPR Gene

Gene Families for HNRNPR Gene

Graphical View of Domain Structure for InterPro Entry

O43390

UniProtKB/Swiss-Prot:

HNRPR_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPR: view

Function for HNRNPR Gene

Molecular function for HNRNPR Gene

UniProtKB/Swiss-Prot Function:
Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

Gene Ontology (GO) - Molecular Function for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding NAS 9421497
GO:0003730 mRNA 3-UTR binding IEA --
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with HNRNPR: view

Phenotypes for HNRNPR Gene

genes like me logo Genes that share phenotypes with HNRNPR: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPR Gene

Localization for HNRNPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPR Gene

Nucleus. Microsome. Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). {ECO:0000250 UniProtKB:Q7TMK9, ECO:0000269 PubMed:17289661}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPR Gene COMPARTMENTS Subcellular localization image for HNRNPR gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 3
cytosol 2

Gene Ontology (GO) - Cellular Components for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA,TAS --
GO:0005681 spliceosomal complex NAS 9421497
GO:0005730 NOT nucleolus IDA 9421497
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HNRNPR: view

Pathways & Interactions for HNRNPR Gene

genes like me logo Genes that share pathways with HNRNPR: view

Pathways by source for HNRNPR Gene

1 Cell Signaling Technology pathway for HNRNPR Gene
1 BioSystems pathway for HNRNPR Gene

Gene Ontology (GO) - Biological Process for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC,TAS --
GO:0006397 mRNA processing NAS 9421497
GO:0007623 circadian rhythm IEA --
GO:0008380 RNA splicing IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with HNRNPR: view

No data available for SIGNOR curated interactions for HNRNPR Gene

Transcripts for HNRNPR Gene

Unigene Clusters for HNRNPR Gene

Heterogeneous nuclear ribonucleoprotein R:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPR Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: - - - -
SP11: - - - -
SP12:
SP13:

Relevant External Links for HNRNPR Gene

GeneLoc Exon Structure for
HNRNPR
ECgene alternative splicing isoforms for
HNRNPR

Expression for HNRNPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNRNPR Gene

Protein differential expression in normal tissues from HIPED for HNRNPR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.2) and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPR Gene



Protein tissue co-expression partners for HNRNPR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPR Gene:

HNRNPR

SOURCE GeneReport for Unigene cluster for HNRNPR Gene:

Hs.373763
genes like me logo Genes that share expression patterns with HNRNPR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPR Gene

Orthologs for HNRNPR Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPR 34 35
  • 99.89 (n)
dog
(Canis familiaris)
Mammalia HNRNPR 34 35
  • 97.21 (n)
cow
(Bos Taurus)
Mammalia HNRNPR 34 35
  • 96.31 (n)
oppossum
(Monodelphis domestica)
Mammalia HNRNPR 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPR 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnpr 34
  • 91.98 (n)
mouse
(Mus musculus)
Mammalia Hnrnpr 34 16 35
  • 91.46 (n)
chicken
(Gallus gallus)
Aves HNRNPR 34 35
  • 85.81 (n)
lizard
(Anolis carolinensis)
Reptilia HNRNPR 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpr 34
  • 75.27 (n)
Str.10730 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6623 34
zebrafish
(Danio rerio)
Actinopterygii hnrnpr 35
  • 79 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12332 34
fruit fly
(Drosophila melanogaster)
Insecta CG17838 35
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-2 35
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToMany
Species where no ortholog for HNRNPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPR Gene

ENSEMBL:
Gene Tree for HNRNPR (if available)
TreeFam:
Gene Tree for HNRNPR (if available)

Paralogs for HNRNPR Gene

Paralogs for HNRNPR Gene

(7) SIMAP similar genes for HNRNPR Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for HNRNPR Gene

genes like me logo Genes that share paralogs with HNRNPR: view

Variants for HNRNPR Gene

Sequence variations from dbSNP and Humsavar for HNRNPR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1045079 -- 23,309,601(-) TTCCA(A/G)TTAGC downstream-variant-500B, utr-variant-3-prime
rs10493016 -- 23,315,530(-) TTAGA(A/T)GAGTG intron-variant
rs10528059 -- 23,345,414(+) CTATA(-/TTTA)ATTAT upstream-variant-2KB
rs10669273 -- 23,331,862(+) AAAAA(-/AAAAAAAG)GGTCC intron-variant
rs10917370 -- 23,316,344(+) CCATA(A/G)TATTT intron-variant

Variation tolerance for HNRNPR Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPR Gene

Human Gene Mutation Database (HGMD)
HNRNPR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HNRNPR Gene

Disorders for HNRNPR Gene

Relevant External Links for HNRNPR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPR

No disorders were found for HNRNPR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPR Gene

Publications for HNRNPR Gene

  1. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. (PMID: 9421497) Hassfeld W. … Tan E.M. (Nucleic Acids Res. 1998) 2 3 4 22 64
  2. Cloning and expression of a novel isoform of heterogeneous nuclear ribonucleoprotein-R. (PMID: 15858414) Huang J. … Xu P. (NeuroReport 2005) 3 4 22 64
  3. The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons. (PMID: 20167579) Glinka M. … Sendtner M. (Hum. Mol. Genet. 2010) 3 22 64
  4. Heterogeneous nuclear ribonucleoprotein R enhances transcription from the naturally configured c-fos promoter in vitro. (PMID: 19581295) Fukuda A. … Hisatake K. (J. Biol. Chem. 2009) 3 22 64
  5. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Joeson L. … Nielsen F.C. (Mol. Cell. Proteomics 2007) 3 4 64

Products for HNRNPR Gene

Sources for HNRNPR Gene

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