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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNRNPR Gene

protein-coding   GIFtS: 54
GCID: GC01M023630

heterogeneous nuclear ribonucleoprotein R


(Previous symbol: HNRPR)
 Explore 5 diseases affiliated with
HNRNPR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HNRNPR    

Aliases
for HNRNPR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heterogeneous Nuclear Ribonucleoprotein R1 2
HNRPR1 2 3 5
HnRNP-R1
HnRNP R2 3

External Ids:    HGNC: 50471   Entrez Gene: 102362   Ensembl: ENSG000001259447   OMIM: 6072015   UniProtKB: O433903   

Export aliases for HNRNPR gene to outside databases

Previous GC identifers: GC01M023509 GC01M021888


Summaries
for HNRNPR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HNRNPR:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated
with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and
transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the
cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has
three repeats of quasi-RRM domains that bind to RNAs and also contains a nuclear localization motif. Multiple
alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HNRPR_HUMAN, O43390
Function: Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear
ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus

Gene Wiki entry for HNRNPR


Genomic Views
for HNRNPR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNRNPR gene promoter:
         GR   USF1   GR-beta   USF-1:USF-2   Nkx2-5   SRY   POU2F1   POU2F1a   GR-alpha   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HNRNPR promoter sequence
   Search SABiosciences Chromatin IP Primers for HNRNPR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.12

HNRNPR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M023630:  view genomic region     (about GC identifiers)

Start:
 23,630,264 bp from pter      End:
 23,670,853 bp from pter
Size:
 40,590 bases      Orientation:
 minus strand

Proteins
for HNRNPR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HNRPR_HUMAN, O43390 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein R  
Size: 633 amino acids; 70943 Da
Subunit: Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB,
ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3,
NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated
mRNAs. Interacts with GTPBP1
Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing
untranslated mRNAs
1 PDB 3D structure from and Proteopedia for HNRNPR:
2DK2 (3D)    
Secondary accessions: Q5TEH1 Q9BV64
Alternative splicing: 2 isoforms:  O43390-1   O43390-2   

Explore the universe of human proteins at neXtProt for HNRNPR: NX_O43390

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43390

    • HNRNPR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001095867.1  NP_001095868.1  NP_001095869.1  NP_005817.1  

    ENSEMBL proteins: 
     ENSP00000363745   ENSP00000363741   ENSP00000304405   ENSP00000392799   ENSP00000415042  
    Reactome Protein details: O43390
    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): HNRNPR
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    Novus Biologicals HNRNPR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HNRNPR

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex NAS9421497
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--


    HNRNPR for ontologies           About GeneDecksing



    HNRNPR Antibody Products: 
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    Uscn ELISAs and CLIAs for HNRNPR

    Protein Domains /
    Families
    for HNRNPR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HNRNPR for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR006535 HnRNP_R/Q_splicing_fac
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O43390

    ProtoNet protein and cluster: O43390

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: HNRPR_HUMAN, O43390
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    Function
    for HNRNPR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HNRPR_HUMAN, O43390
    Function: Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear
    ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus

    miRNA
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    hsa-miR-2052 hsa-miR-498 hsa-miR-4307 hsa-miR-300 hsa-miR-606 hsa-miR-641 hsa-miR-7-1* hsa-miR-2276
    SwitchGear 3'UTR luciferase reporter plasmid: HNRNPR 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding NAS9421497
    GO:0005515protein binding IPI17474147


    HNRNPR for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HNRNPR:
     Decreased circadian period len 


    Pathways & Interactions
    for HNRNPR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA Splicing - Major Pathway1.00
    		mRNA Processing0.82
    		mRNA Splicing1.00
    		mRNA processing0.48
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    2Translational Control
    		Translational Control1.00
    3Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HNRNPR
        Translational Control

    1 BioSystems Pathway for HNRNPR 
        mRNA processing

    5        Reactome Pathways for HNRNPR
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA



    HNRNPR for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HNRNPR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/690 Interacting proteins for HNRNPR (O433901, 2, 3 ENSP000003637454) via UniProtKB, MINT, STRING, and/or I2D (see all 690)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 I2D: score=3 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7945693 I2D: score=3 STRING: ENSP00000370119
    FARSAQ9Y2852, 3, ENSP000003203094MINT-65368 I2D: score=4 STRING: ENSP00000320309
    RPL26P612542, 3, ENSP000002938424MINT-65366 I2D: score=4 STRING: ENSP00000293842
    ABL1P005192, 3, ENSP000003614234MINT-8110455 I2D: score=3 STRING: ENSP00000361423
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing NAS9421497
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--


    HNRNPR for ontologies           About GeneDecksing



    Drugs & Compounds
    for HNRNPR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HNRNPR
    Search CenterWatch for drugs/clinical trials and news about HNRNPR / HNRPR 

    Transcripts
    for HNRNPR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HNRNPR gene (4 alternative transcripts): 
    NM_001102397.1  NM_001102398.1  NM_001102399.1  NM_005826.3  

    Unigene Cluster for HNRNPR:

    Heterogeneous nuclear ribonucleoprotein R
    Hs.373763  [show with all ESTs]
    Unigene Representative Sequence: BX647784
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464516 ENST00000478691(uc001bgs.4 uc009vqk.3 uc010odx.2 uc009vql.3)
    ENST00000374616(uc001bgp.4) ENST00000476660(uc001bgo.3) ENST00000374612(uc001bgr.4 uc010odw.2)
    ENST00000302271 ENST00000463552 ENST00000470941 ENST00000476451 ENST00000491459
    ENST00000490652 ENST00000427764 ENST00000426846

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRNPR (see all 17):
    hsa-miR-2052 hsa-miR-498 hsa-miR-4307 hsa-miR-300 hsa-miR-606 hsa-miR-641 hsa-miR-7-1* hsa-miR-2276
    SwitchGear 3'UTR luciferase reporter plasmid: HNRNPR 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HNRNPR (see all 4)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF000364.1 AK001846.1 AK098580.1 AK297382.1 AK297405.1 AK300029.1 AK311519.1 AK313142.1 
    BC001449.2 BC110389.1 BX538163.1 BX640912.1 BX647784.1 DQ351905.1 

    24/28 DOTS entries (see all 28):

    DT.309325  DT.100826223  DT.100826229  DT.95184997  DT.451851  DT.91946687  DT.100668861  DT.100826231 
    DT.95263190  DT.91766504  DT.121354628  DT.121354569  DT.75138084  DT.91766495  DT.100773054  DT.121354563 
    DT.121354541  DT.121354542  DT.91766498  DT.101961283  DT.121354553  DT.121354559  DT.121354562  DT.121354614 

    24/569 AceView cDNA sequences (see all 569):

    AI868436 R33042 BU685539 BM835617 AW272227 BU162215 AA055729 CA395054 
    AA318353 BI869277 AA278394 CA397911 AL134749 BM726605 AI263848 BQ876248 
    AI817228 BU629406 BQ009796 BM888324 BE396797 AF000364 AA486402 AI273292 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPR (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                                -                             -     -           -                             -                                 
    SP2:                                -                             -     -                                         -                                 
    SP3:              -                 -                             -     -                                         -                                 
    SP4:              -                 -                             -     -           -                                                               
    SP5:              -                 -                 -           -     -           -                                                               


    ECgene alternative splicing isoforms for HNRNPR

    Expression
    for HNRNPR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNRNPR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAGATTTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HNRNPR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNRNPR

    SOURCE GeneReport for Unigene cluster: Hs.373763
        SABiosciences Custom PCR Arrays for HNRNPR
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    In Situ
    Assay Products:     
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    Orthologs
    for HNRNPR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HNRNPR gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HNRNPR1 heterogeneous nuclear ribonucleoprotein R 88.34(n)
    97.94(a)    		   419570  NM_001006309.3  NP_001006309.3 
    lizard
    (Anolis carolinensis)    		 Reptilia HNRNPR6
    		 --
    		 98(a)
    		 1 ↔ 1
    		 GL343743.1(188988-199922)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.66232 Xenopus laevis transcribed sequence with strong similarity more 79.6(n)    BQ734736.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hnrpr6
    		 heterogeneous nuclear ribonucleoprotein R
    		 78(a)
    		 possible ortholog
    		 19(40444-48614)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG178381 CG17838 53.23(n)
    55.78(a)    		   42460  NM_142656.3  NP_650913.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea hrp-21 Protein HRP-2 53.11(n)
    48.21(a)    		   173086  NM_060648.2  NP_493049.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G008301 RNA recognition motif-containing protein 45.96(n)
    36.32(a)    		   827998  NM_001036489.2  NP_001031566.1 
    rice
    (Oryza sativa)    		 Liliopsida Os10g01518001 hypothetical protein 49.52(n)
    38.66(a)    		   4348127  NM_001070716.1  NP_001064181.1 


    ENSEMBL Gene Tree for HNRNPR (if available)
    TreeFam Gene Tree for HNRNPR (if available) 

    Paralogs
    for HNRNPR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HNRNPR gene
    RBM472  SYNCRIP2  DND12  RBM462  A1CF2  
    7 SIMAP similar genes for HNRNPR using alignment to 3 protein entries:     HNRPR_HUMAN (see all proteins):
    DKFZp686O0665    HNRPR    DKFZp686A13234    SYNCRIP    A1CF    RBM46
    RBM47

    HNRNPR for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for HNRNPR
    PGOHUM00000251234 PGOHUM00000242200 PGOHUM00000245880


    Genomic Variants
    for HNRNPR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/584 NCBI SNPs in HNRNPR are shown (see all 584)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1485766261,2
    		--23635845(+) CAATTC/TTCCCT 4 -- ds50010--------
    rs127565971,2
    		C--23635986(+) ATGCCT/GGCAAG 4 -- ds50011Minor allele frequency- G:0.00NA 2
    rs561965961,2
    		C--23636016(+) TTTTT-/TAATAA 4 -- ds50011Minor allele frequency- T:0.00NA 2
    rs588371661,2
    		C--23636016(+) ACCTG-/TTTTTTT 4 -- ds50010--------
    rs1844444101,2
    		--23636033(+) TAATAA/GAAGAT 4 -- ds50010--------
    rs1891463771,2
    		--23636064(+) GACTAC/TGAGAG 4 -- ds50010--------
    rs10450791,2
    		C,F,H,--23636094(-) TTCCAA/GTTAGC 4 -- ds500113Minor allele frequency- G:0.12NS EA NA WA 1350
    rs1389190091,2
    		--23636146(+) AACAC-/ATGTTGG 4 -- ds50010--------
    rs560976601,2
    		C--23636349(+) CATCAA/GAGAAC 4 -- ut310--------
    rs1818147271,2
    		--23636358(+) ACAAAC/TTGTCA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for HNRNPR (23630264 - 23670853 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HNRNPR: --

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    Disorders / Diseases
    for HNRNPR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HNRNPR for disorders           About GeneDecksing

    OMIM gene information: 607201    OMIM disorders: --

    5 diseases for HNRNPR:    About MalaCards
    spinal muscular atrophy    muscular atrophy    hepatocellular carcinoma    carcinoma
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for HNRNPR:
    Spinal muscular atrophy

    Export disorders for HNRNPR gene to outside databases

    Publications
    for HNRNPR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNRNPR gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with HNRNPR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. (PubMed id 9421497)1, 2, 3, 9 Hassfeld W.... Tan E.M. (1998)
    2. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    5. Heterogeneous nuclear ribonucleoprotein R enhances tr anscription from the naturally configured c-fos promoter in vitro. (PubMed id 19581295)1, 9 Fukuda A....Hisatake K. (2009)
    6. Cloning and expression of a novel isoform of heterogeneous nuclear ribonucleoprotein-R. (PubMed id 15858414)1, 9 Huang J.... Xu P. (2005)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Biochemical and phosphoproteomic analysis of the helix -loop-helix protein E47. (PubMed id 22354994)1 Teachenor R....Murre C. (2012)

    External Searches for HNRNPR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HNRNPR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10236 HGNC: 5047 AceView: HNRPR Ensembl:ENSG00000125944 euGenes: HUgn10236
    ECgene: HNRNPR H-InvDB: HNRNPR

    Other Databases showing HNRNPR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HNRNPR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNRNPR Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HNRNPR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HNRNPR gene:
    Search GeneIP for patents involving HNRNPR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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