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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNRNPR Gene

protein-coding   GIFtS: 56
GCID: GC01M023630

Heterogeneous Nuclear Ribonucleoprotein R


(Previous symbol: HNRPR)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heterogeneous Nuclear Ribonucleoprotein R1 2
HNRPR1 2 3 5
HnRNP R2 3
hnRNP-R2

External Ids:    HGNC: 50471   Entrez Gene: 102362   Ensembl: ENSG000001259447   OMIM: 6072015   UniProtKB: O433903   

Export aliases for HNRNPR gene to outside databases

Previous GC identifers: GC01M023509 GC01M021888


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HNRNPR Gene:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are
associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA
metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the
nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded
by this gene has three repeats of quasi-RRM domains that bind to RNAs and also contains a nuclear localization
motif. Multiple alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for HNRNPR Gene: 
HNRNPR (heterogeneous nuclear ribonucleoprotein R) is a protein-coding gene. Diseases associated with HNRNPR include spinal muscular atrophy, and muscular atrophy, and among its related super-pathways are mRNA Processing and Generic Transcription Pathway. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SYNCRIP.

UniProtKB/Swiss-Prot: HNRPR_HUMAN, O43390
Function: Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear
ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus

Gene Wiki entry for HNRNPR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNRNPR gene promoter:
         GR   USF1   GR-beta   USF-1:USF-2   Nkx2-5   SRY   POU2F1   POU2F1a   GR-alpha   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HNRNPR promoter sequence
   Search SABiosciences Chromatin IP Primers for HNRNPR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.12

HNRNPR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M023630:  view genomic region     (about GC identifiers)

Start:
23,630,264 bp from pter      End:
23,670,853 bp from pter
Size:
40,590 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HNRPR_HUMAN, O43390 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein R  
Size: 633 amino acids; 70943 Da
Subunit: Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB,
ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3,
NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated
mRNAs. Interacts with GTPBP1
Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing
untranslated mRNAs
1 PDB 3D structure from and Proteopedia for HNRNPR:
2DK2 (3D)    
Secondary accessions: Q2L7G6 Q5TEH1 Q9BV64
Alternative splicing: 3 isoforms:  O43390-1   O43390-2   O43390-3   (Expression is low and neural-specific)

Explore the universe of human proteins at neXtProt for HNRNPR: NX_O43390

Explore proteomics data for HNRNPR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43390

  • HNRNPR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HNRNPR Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001095867.1  NP_001095868.1  NP_001095869.1  NP_005817.1  

    ENSEMBL proteins: 
     ENSP00000474437   ENSP00000363745   ENSP00000363741   ENSP00000304405   ENSP00000475760  
     ENSP00000392799   ENSP00000415042  
    Reactome Protein details: O43390
    Human Recombinant Protein Products for HNRNPR: 
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    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex NAS9421497
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    HNRNPR for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR006535 HnRNP_R/Q_splicing_fac
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O43390

    ProtoNet protein and cluster: O43390

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: HNRPR_HUMAN, O43390
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    HNRNPR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRPR_HUMAN, O43390
    Function: Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear
    ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding NAS9421497
    GO:0005515protein binding IPI17474147
         
    HNRNPR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HNRNPR:
     Decreased circadian period len 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidHNRNPR 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HNRNPR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA processing0.46
    mRNA Splicing - Major Pathway0.82
    2Generic Transcription Pathway
    Gene Expression0.47
    3Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HNRNPR
        Translational Control

    1 BioSystems Pathway for HNRNPR
        mRNA processing


    5        Reactome Pathways for HNRNPR
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA



    HNRNPR for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HNRNPR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/726 Interacting proteins for HNRNPR (O433901, 2, 3 ENSP000003637454) via UniProtKB, MINT, STRING, and/or I2D (see all 726)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 I2D: score=3 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7945693 I2D: score=3 STRING: ENSP00000370119
    FARSAQ9Y2852, 3, ENSP000003203094MINT-65368 I2D: score=4 STRING: ENSP00000320309
    RPL26P612542, 3, ENSP000002938424MINT-65366 I2D: score=4 STRING: ENSP00000293842
    ABL1P005192, 3, ENSP000003614234MINT-8110455 I2D: score=3 STRING: ENSP00000361423
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing NAS9421497
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    HNRNPR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HNRNPR (HNRPR)

    Search CenterWatch for drugs/clinical trials and news about HNRNPR / HNRPR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HNRNPR gene (4 alternative transcripts): 
    NM_001102397.1  NM_001102398.1  NM_001102399.1  NM_005826.3  

    Unigene Cluster for HNRNPR:

    Heterogeneous nuclear ribonucleoprotein R
    Hs.373763  [show with all ESTs]
    Unigene Representative Sequence: BX647784
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464516 ENST00000478691(uc001bgs.4 uc009vqk.3 uc010odx.2 uc009vql.3)
    ENST00000374616(uc001bgp.4) ENST00000476660(uc001bgo.3) ENST00000374612(uc001bgr.4 uc010odw.2)
    ENST00000302271 ENST00000606561 ENST00000463552 ENST00000470941 ENST00000476451
    ENST00000490652 ENST00000427764 ENST00000426846
    miRNA
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    Additional mRNA sequence: 

    AF000364.1 AK001846.1 AK098580.1 AK297382.1 AK297405.1 AK300029.1 AK311519.1 AK313142.1 
    BC001449.2 BC110389.1 BX538163.1 BX640912.1 BX647784.1 DQ351905.1 

    24/28 DOTS entries (see all 28):

    DT.309325  DT.100826223  DT.100826229  DT.95184997  DT.451851  DT.91946687  DT.100668861  DT.100826231 
    DT.95263190  DT.91766504  DT.121354628  DT.121354569  DT.75138084  DT.91766495  DT.100773054  DT.121354563 
    DT.121354541  DT.121354542  DT.91766498  DT.101961283  DT.121354553  DT.121354559  DT.121354562  DT.121354614 

    24/569 AceView cDNA sequences (see all 569):

    AL531879 AL557253 BQ053474 AU125048 AI826420 BQ778483 BU174940 AU143588 
    NM_005826 CA443396 BG575173 AA278394 BU685539 BC001449 BU739861 AI400650 
    AU130315 CN480593 CB132129 BE251227 BU175143 BM842672 BU621279 AW628275 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPR (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                                -                             -     -           -                             -                                 
    SP2:                                -                             -     -                                         -                                 
    SP3:              -                 -                             -     -                                         -                                 
    SP4:              -                 -                             -     -           -                                                               
    SP5:              -                 -                 -           -     -           -                                                               


    ECgene alternative splicing isoforms for HNRNPR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNRNPR expression in normal human tissues (normalized intensities)      HNRNPR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGATTTCA
    HNRNPR Expression
    About this image


    HNRNPR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             cortex   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See HNRNPR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNRNPR

    SOURCE GeneReport for Unigene cluster: Hs.373763
        SABiosciences Custom PCR Arrays for HNRNPR
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HNRNPR gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpr1 , 5 heterogeneous nuclear ribonucleoprotein R1, 5 94.04(n)1
    99.68(a)1
      4 (68.40 cM)5
    743261  NM_028871.11  NP_083147.11 
     1363109765 
    chicken
    (Gallus gallus)
    Aves HNRNPR1 heterogeneous nuclear ribonucleoprotein R 88.34(n)
    97.94(a)
      419570  NM_001006309.3  NP_001006309.3 
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPR6
    heterogeneous nuclear ribonucleoprotein R
    93(a)
    1 ↔ 1
    GL343743.1(182374-204980)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.66232 Xenopus laevis transcribed sequence with strong similarity more 79.6(n)    BQ734736.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hnrnpr6
    heterogeneous nuclear ribonucleoprotein R
    79(a)
    possible ortholog
    19(40444-48614)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG178381 CG17838 53.23(n)
    55.78(a)
      42460  NM_142656.3  NP_650913.2 
    worm
    (Caenorhabditis elegans)
    Secernentea hrp-21 Protein HRP-2 53.11(n)
    48.21(a)
      173086  NM_060648.2  NP_493049.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G008301 RNA recognition motif-containing protein 45.96(n)
    36.32(a)
      827998  NM_001036489.2  NP_001031566.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g01518001 hypothetical protein 49.52(n)
    38.66(a)
      4348127  NM_001070716.1  NP_001064181.1 


    ENSEMBL Gene Tree for HNRNPR (if available)
    TreeFam Gene Tree for HNRNPR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HNRNPR gene
    SYNCRIP2  RBM472  DND12  RBM462  A1CF2  
    7 SIMAP similar genes for HNRNPR using alignment to 2 protein entries:     HNRPR_HUMAN (see all proteins):
    DKFZp686O0665    DKFZp686A13234    HNRPR    SYNCRIP    A1CF    RBM46
    RBM47

    HNRNPR for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for HNRNPR
    PGOHUM00000251234 PGOHUM00000242200 PGOHUM00000245880


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/735 SNPs in HNRNPR are shown (see all 735)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710204991,2
    C--21915184(+) AAAAA-/A/    
       AAAAA
    TTAGC
    4 -- int11NA 2
    rs1485766261,2
    --23635845(+) CAATTC/TTCCCT 4 -- ds50010--------
    rs127565971,2
    C--23635986(+) ATGCCT/GGCAAG 4 -- ds50011Minor allele frequency- G:0.00NA 2
    rs38354211,2
    C--23636016(-) AAAAA-/A/AA  
            
    CAGGT
    4 -- ds50010--------
    rs561965961,2
    C--23636028(+) TTTTT-/TAATAA 4 -- ds50011Minor allele frequency- T:0.00NA 2
    rs1844444101,2
    --23636033(+) TAATAA/GAAGAT 4 -- ds50010--------
    rs1891463771,2
    --23636064(+) GACTAC/TGAGAG 4 -- ds50010--------
    rs10450791,2
    C,F,H--23636094(-) TTCCAA/GTTAGC 4 -- ds500113Minor allele frequency- G:0.12NS EA NA WA 1350
    rs1389190091,2
    C--23636146(+) AACAC-/ATGTTGG 4 -- ds50010--------
    rs560976601,2
    C--23636349(+) CATCAA/GAGAAC 4 -- ut310--------

    HapMap Linkage Disequilibrium report for HNRNPR (23630264 - 23670853 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HNRNPR: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPR
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607201    OMIM disorders: --

    5 diseases for HNRNPR:    About MalaCards
    spinal muscular atrophy    muscular atrophy    hepatocellular carcinoma    neuronitis
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for HNRNPR:
    Spinal muscular atrophy

    HNRNPR for disorders           About GeneDecksing


    Export disorders for HNRNPR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNRNPR gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with HNRNPR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. (PubMed id 9421497)1, 2, 3, 9 Hassfeld W.... Tan E.M. (1998)
    2. Cloning and expression of a novel isoform of heterogeneous nuclear ribonucleoprotein-R. (PubMed id 15858414)1, 2, 9 Huang J.... Xu P. (2005)
    3. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    6. Heterogeneous nuclear ribonucleoprotein R enhances tr anscription from the naturally configured c-fos promoter in vitro. (PubMed id 19581295)1, 9 Fukuda A....Hisatake K. (2009)
    7. The novel ubiquitin ligase complex, SCF(Fbxw4), intera cts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. (PubMed id 23658844)1 Lockwood W.W....Beverly L.J. (2013)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. Cleavage and polyadenylation specificity factor 1 (CPS F1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10236 HGNC: 5047 AceView: HNRPR Ensembl:ENSG00000125944 euGenes: HUgn10236
    ECgene: HNRNPR H-InvDB: HNRNPR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNRNPR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HNRNPR gene:
    Search GeneIP for patents involving HNRNPR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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