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Aliases for HNRNPR Gene

Aliases for HNRNPR Gene

  • Heterogeneous Nuclear Ribonucleoprotein R 2 3 5
  • HNRPR 3 4
  • HnRNP-R 3
  • HnRNP R 4

External Ids for HNRNPR Gene

Previous HGNC Symbols for HNRNPR Gene

  • HNRPR

Previous GeneCards Identifiers for HNRNPR Gene

  • GC01M023509
  • GC01M023630
  • GC01M021888

Summaries for HNRNPR Gene

Entrez Gene Summary for HNRNPR Gene

  • This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]

GeneCards Summary for HNRNPR Gene

HNRNPR (Heterogeneous Nuclear Ribonucleoprotein R) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBM47.

UniProtKB/Swiss-Prot for HNRNPR Gene

  • Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

Gene Wiki entry for HNRNPR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPR Gene

Genomics for HNRNPR Gene

Regulatory Elements for HNRNPR Gene

Promoters for HNRNPR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HNRNPR on UCSC Golden Path with GeneCards custom track

Genomic Location for HNRNPR Gene

Chromosome:
1
Start:
23,303,771 bp from pter
End:
23,344,650 bp from pter
Size:
40,880 bases
Orientation:
Minus strand

Genomic View for HNRNPR Gene

Genes around HNRNPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPR Gene

Proteins for HNRNPR Gene

  • Protein details for HNRNPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43390-HNRPR_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein R
    Protein Accession:
    O43390
    Secondary Accessions:
    • Q2L7G6
    • Q5TEH1
    • Q9BV64
    • S4R3J4

    Protein attributes for HNRNPR Gene

    Size:
    633 amino acids
    Molecular mass:
    70943 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with GTPBP1.

    Three dimensional structures from OCA and Proteopedia for HNRNPR Gene

    Alternative splice isoforms for HNRNPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPR Gene

Proteomics data for HNRNPR Gene at MOPED

Post-translational modifications for HNRNPR Gene

  • Ubiquitination at Lys 41, Lys 187, and Lys 359
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HNRNPR (hnRNP R)

No data available for DME Specific Peptides for HNRNPR Gene

Domains & Families for HNRNPR Gene

Gene Families for HNRNPR Gene

Graphical View of Domain Structure for InterPro Entry

O43390

UniProtKB/Swiss-Prot:

HNRPR_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPR: view

Function for HNRNPR Gene

Molecular function for HNRNPR Gene

UniProtKB/Swiss-Prot Function:
Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

Gene Ontology (GO) - Molecular Function for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 9421497
genes like me logo Genes that share ontologies with HNRNPR: view

Phenotypes for HNRNPR Gene

genes like me logo Genes that share phenotypes with HNRNPR: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPR Gene

Localization for HNRNPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPR Gene

Nucleus. Microsome. Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). {ECO:0000250 UniProtKB:Q7TMK9, ECO:0000269 PubMed:17289661}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPR Gene COMPARTMENTS Subcellular localization image for HNRNPR gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 3
cytosol 2

Gene Ontology (GO) - Cellular Components for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0030425 dendrite IEA --
GO:0030529 intracellular ribonucleoprotein complex IDA 17289661
genes like me logo Genes that share ontologies with HNRNPR: view

Pathways & Interactions for HNRNPR Gene

genes like me logo Genes that share pathways with HNRNPR: view

Pathways by source for HNRNPR Gene

Gene Ontology (GO) - Biological Process for HNRNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0007623 circadian rhythm IEA --
GO:0061014 positive regulation of mRNA catabolic process IEA --
genes like me logo Genes that share ontologies with HNRNPR: view

No data available for SIGNOR curated interactions for HNRNPR Gene

Drugs & Compounds for HNRNPR Gene

No Compound Related Data Available

Transcripts for HNRNPR Gene

Unigene Clusters for HNRNPR Gene

Heterogeneous nuclear ribonucleoprotein R:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPR Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: - - - -
SP11: - - - -
SP12:
SP13:

Relevant External Links for HNRNPR Gene

GeneLoc Exon Structure for
HNRNPR
ECgene alternative splicing isoforms for
HNRNPR

Expression for HNRNPR Gene

mRNA expression in normal human tissues for HNRNPR Gene

Protein differential expression in normal tissues from HIPED for HNRNPR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.2) and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPR Gene



SOURCE GeneReport for Unigene cluster for HNRNPR Gene Hs.373763

genes like me logo Genes that share expression patterns with HNRNPR: view

Protein tissue co-expression partners for HNRNPR Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPR Gene

Orthologs for HNRNPR Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HNRNPR 35
  • 96.31 (n)
  • 99.84 (a)
HNRNPR 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPR 35
  • 97.21 (n)
  • 100 (a)
HNRNPR 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpr 35
  • 91.46 (n)
  • 95.89 (a)
Hnrnpr 16
Hnrnpr 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HNRNPR 35
  • 99.89 (n)
  • 100 (a)
HNRNPR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnpr 35
  • 91.98 (n)
  • 95.73 (a)
oppossum
(Monodelphis domestica)
Mammalia HNRNPR 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPR 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPR 35
  • 85.81 (n)
  • 93.2 (a)
HNRNPR 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPR 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpr 35
  • 75.27 (n)
  • 84.18 (a)
Str.10730 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6623 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12332 35
zebrafish
(Danio rerio)
Actinopterygii hnrnpr 36
  • 79 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17838 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-2 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for HNRNPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPR Gene

ENSEMBL:
Gene Tree for HNRNPR (if available)
TreeFam:
Gene Tree for HNRNPR (if available)

Paralogs for HNRNPR Gene

Paralogs for HNRNPR Gene

(7) SIMAP similar genes for HNRNPR Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for HNRNPR Gene

genes like me logo Genes that share paralogs with HNRNPR: view

Variants for HNRNPR Gene

Sequence variations from dbSNP and Humsavar for HNRNPR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs585180 -- 23,312,651(+) AAGCC(A/G)ATTAA intron-variant
rs593246 -- 23,325,268(+) AAAAA(C/T)AGCTG intron-variant
rs593710 -- 23,325,375(+) AGATG(G/T)ACTAT intron-variant
rs613869 -- 23,313,729(+) AAACC(A/G)TCATT intron-variant
rs581834 -- 23,311,896(+) TACTT(C/T)GCTTG intron-variant

Variation tolerance for HNRNPR Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPR Gene

HapMap Linkage Disequilibrium report
HNRNPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HNRNPR Gene

Disorders for HNRNPR Gene

Relevant External Links for HNRNPR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPR

No disorders were found for HNRNPR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPR Gene

Publications for HNRNPR Gene

  1. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. (PMID: 9421497) Hassfeld W. … Tan E.M. (Nucleic Acids Res. 1998) 2 3 4 23 67
  2. The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons. (PMID: 20167579) Glinka M. … Sendtner M. (Hum. Mol. Genet. 2010) 3 23
  3. Heterogeneous nuclear ribonucleoprotein R enhances transcription from the naturally configured c-fos promoter in vitro. (PMID: 19581295) Fukuda A. … Hisatake K. (J. Biol. Chem. 2009) 3 23
  4. Cloning and expression of a novel isoform of heterogeneous nuclear ribonucleoprotein-R. (PMID: 15858414) Huang J. … Xu P. (NeuroReport 2005) 3 23
  5. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3

Products for HNRNPR Gene

Sources for HNRNPR Gene

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