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Aliases for HNRNPM Gene

Aliases for HNRNPM Gene

  • Heterogeneous Nuclear Ribonucleoprotein M 2 3
  • HNRPM 3 4 6
  • NAGR1 3 4 6
  • CEA Receptor 2 3
  • HnRNP M 3 4
  • HNRPM4 3 6
  • Heterogenous Nuclear Ribonucleoprotein M4 3
  • N-Acetylglucosamine Receptor 1 3
  • HnRNA-Binding Protein M4 3
  • HNRNPM4 3
  • HTGR1 3
  • CEAR 3

External Ids for HNRNPM Gene

Previous Symbols for HNRNPM Gene

  • NAGR1
  • HNRPM

Summaries for HNRNPM Gene

Entrez Gene Summary for HNRNPM Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for HNRNPM Gene

HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include RNA binding and protein domain specific binding. An important paralog of this gene is MYEF2.

UniProtKB/Swiss-Prot for HNRNPM Gene

  • Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPM Gene

Genomics for HNRNPM Gene

Genomic Location for HNRNPM Gene

Start:
8,444,576 bp from pter
End:
8,489,118 bp from pter
Size:
44,543 bases
Orientation:
Plus strand

Genomic View for HNRNPM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPM Gene

Regulatory Elements for HNRNPM Gene

Proteins for HNRNPM Gene

  • Protein details for HNRNPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52272-HNRPM_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein M
    Protein Accession:
    P52272
    Secondary Accessions:
    • Q15584
    • Q8WZ44
    • Q96H56
    • Q9BWL9
    • Q9Y492

    Protein attributes for HNRNPM Gene

    Size:
    730 amino acids
    Molecular mass:
    77516 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for HNRNPM Gene

    Alternative splice isoforms for HNRNPM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPM Gene

Proteomics data for HNRNPM Gene at MOPED

Post-translational modifications for HNRNPM Gene

  • Sumoylated.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys69, Lys83, Lys88, Lys110, Lys127, Lys345, Lys381, Lys388, Lys651, Lys667, Lys698, and Lys716

No data available for DME Specific Peptides for HNRNPM Gene

Domains for HNRNPM Gene

Gene Families for HNRNPM Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

UniProtKB/Swiss-Prot:

HNRPM_HUMAN
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.:
    • P52272
genes like me logo Genes that share domains with HNRNPM: view

Function for HNRNPM Gene

Molecular function for HNRNPM Gene

UniProtKB/Swiss-Prot Function: Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines

Gene Ontology (GO) - Molecular Function for HNRNPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 9731529
GO:0005515 protein binding IPI 18457437
GO:0019904 protein domain specific binding IPI 11984006
genes like me logo Genes that share ontologies with HNRNPM: view
genes like me logo Genes that share phenotypes with HNRNPM: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPM Gene

Localization for HNRNPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPM Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPM Gene COMPARTMENTS Subcellular localization image for HNRNPM gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2
chloroplast 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HNRNPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005730 nucleolus IEA --
GO:0005887 integral component of plasma membrane TAS 8088785
genes like me logo Genes that share ontologies with HNRNPM: view

Pathways for HNRNPM Gene

genes like me logo Genes that share pathways with HNRNPM: view

Pathways by source for HNRNPM Gene

1 KEGG pathway for HNRNPM Gene

Gene Ontology (GO) - Biological Process for HNRNPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome IMP 19874820
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with HNRNPM: view

Transcripts for HNRNPM Gene

Unigene Clusters for HNRNPM Gene

Heterogeneous nuclear ribonucleoprotein M:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPM Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5:
SP6:

Relevant External Links for HNRNPM Gene

GeneLoc Exon Structure for
HNRNPM
ECgene alternative splicing isoforms for
HNRNPM

Expression for HNRNPM Gene

mRNA expression in normal human tissues for HNRNPM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPM Gene

SOURCE GeneReport for Unigene cluster for HNRNPM Gene Hs.465808

genes like me logo Genes that share expressions with HNRNPM: view

Orthologs for HNRNPM Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPM 36
  • 99.59 (n)
  • 100 (a)
HNRNPM 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 78 (a)
OneToMany
-- 37
  • 99 (a)
OneToMany
HNRNPM 36
  • 95.3 (n)
  • 99.32 (a)
dog
(Canis familiaris)
Mammalia HNRNPM 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpm 36
  • 93.02 (n)
  • 97.63 (a)
Hnrnpm 16
Hnrnpm 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 83 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 92 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hnrnpm 36
  • 93.06 (n)
  • 98.18 (a)
chicken
(Gallus gallus)
Aves HNRNPM 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5477 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1972 36
zebrafish
(Danio rerio)
Actinopterygii hnrnpm 37
  • 52 (a)
OneToOne
wufa10g07 36
fruit fly
(Drosophila melanogaster)
Insecta rump 37
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C25A1.4 37
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GBP2 37
  • 23 (a)
ManyToMany
GBP2 39
HRB1 37
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7224 37
  • 36 (a)
OneToMany
Species with no ortholog for HNRNPM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPM Gene

ENSEMBL:
Gene Tree for HNRNPM (if available)
TreeFam:
Gene Tree for HNRNPM (if available)

Paralogs for HNRNPM Gene

Paralogs for HNRNPM Gene

Pseudogenes.org Pseudogenes for HNRNPM Gene

genes like me logo Genes that share paralogs with HNRNPM: view

Variants for HNRNPM Gene

Sequence variations from dbSNP and Humsavar for HNRNPM Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs6992 -- 8,488,746(+) TGTGG(C/T)GTGGT reference, synonymous-codon
rs9309 -- 8,488,866(+) GCCTT(G/T)TTTAA utr-variant-3-prime
rs511004 -- 8,450,729(-) aaaaa(A/T)aataa intron-variant
rs563320 -- 8,452,502(-) CAAAA(G/T)AAAGT intron-variant
rs628532 -- 8,465,165(-) TACCA(C/G)CTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPM Gene

Variant ID Type Subtype PubMed ID
dgv3719n71 CNV Loss 21882294
nsv911004 CNV Loss 21882294
esv2335907 CNV Deletion 18987734
esv4060 CNV Deletion 18987735
esv2718124 CNV Deletion 23290073
esv989310 CNV Deletion 20482838
esv7145 CNV Loss 19470904
esv1320041 CNV Deletion 17803354
dgv3720n71 CNV Loss 21882294
dgv3721n71 CNV Loss 21882294
nsv458350 CNV Loss 19166990
dgv396n27 CNV Loss 19166990

Relevant External Links for HNRNPM Gene

HapMap Linkage Disequilibrium report
HNRNPM

Disorders for HNRNPM Gene

No disorders were found for HNRNPM Gene.

No data available for UniProtKB/Swiss-Prot for HNRNPM Gene

Publications for HNRNPM Gene

  1. The human hnRNP M proteins: identification of a methionine/arginine- rich repeat motif in ribonucleoproteins. (PMID: 8441656) Datar K.V. … Swanson M.S. (Nucleic Acids Res. 1993) 2 3 4
  2. The human hnRNP-M proteins: structure and relation with early heat shock-induced splicing arrest and chromosome mapping. (PMID: 8692693) Gattoni R. … Fuchs J.-P. (Nucleic Acids Res. 1996) 3 4
  3. hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures. (PMID: 19874820) Marko M. … Guialis A. (Exp. Cell Res. 2010) 3 23
  4. Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. (PMID: 20467437) LlA"res D. … Lamond A.I. (EMBO Rep. 2010) 3 23
  5. Molecular cloning, cDNA analysis, and localization of a monomer of the N-acetylglucosamine-specific receptor of the thyroid, NAGR1, to chromosome 19p13.3-13.2. (PMID: 7558047) Blanck O. … Miquelis R. (Genomics 1995) 2 3

Products for HNRNPM Gene

Sources for HNRNPM Gene

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