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Aliases for HNRNPM Gene

Aliases for HNRNPM Gene

  • Heterogeneous Nuclear Ribonucleoprotein M 2 3 5
  • CEA Receptor 2 3
  • HnRNP M 3 4
  • HNRPM 3 4
  • NAGR1 3 4
  • Heterogenous Nuclear Ribonucleoprotein M4 3
  • N-Acetylglucosamine Receptor 1 3
  • HnRNA-Binding Protein M4 3
  • HNRNPM4 3
  • HNRPM4 3
  • HTGR1 3
  • CEAR 3

External Ids for HNRNPM Gene

Previous HGNC Symbols for HNRNPM Gene

  • NAGR1
  • HNRPM

Previous GeneCards Identifiers for HNRNPM Gene

  • GC19P008416
  • GC19P008509
  • GC19P008165

Summaries for HNRNPM Gene

Entrez Gene Summary for HNRNPM Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for HNRNPM Gene

HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MYEF2.

UniProtKB/Swiss-Prot for HNRNPM Gene

  • Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPM Gene

Genomics for HNRNPM Gene

Regulatory Elements for HNRNPM Gene

Promoters for HNRNPM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HNRNPM on UCSC Golden Path with GeneCards custom track

Genomic Location for HNRNPM Gene

Chromosome:
19
Start:
8,444,575 bp from pter
End:
8,489,118 bp from pter
Size:
44,544 bases
Orientation:
Plus strand

Genomic View for HNRNPM Gene

Genes around HNRNPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPM Gene

Proteins for HNRNPM Gene

  • Protein details for HNRNPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52272-HNRPM_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein M
    Protein Accession:
    P52272
    Secondary Accessions:
    • Q15584
    • Q8WZ44
    • Q96H56
    • Q9BWL9
    • Q9Y492

    Protein attributes for HNRNPM Gene

    Size:
    730 amino acids
    Molecular mass:
    77516 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for HNRNPM Gene

    Alternative splice isoforms for HNRNPM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPM Gene

Proteomics data for HNRNPM Gene at MOPED

Post-translational modifications for HNRNPM Gene

  • Sumoylated.
  • Ubiquitination at Lys 69, Lys 83, Lys 88, Lys 110, Lys 127, Lys 345, Lys 381, Lys 388, Lys 651, Lys 667, Lys 698, and Lys 716
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPM Gene

Domains & Families for HNRNPM Gene

Gene Families for HNRNPM Gene

Suggested Antigen Peptide Sequences for HNRNPM Gene

Graphical View of Domain Structure for InterPro Entry

P52272

UniProtKB/Swiss-Prot:

HNRPM_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPM: view

Function for HNRNPM Gene

Molecular function for HNRNPM Gene

UniProtKB/Swiss-Prot Function:
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

Gene Ontology (GO) - Molecular Function for HNRNPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0048306 calcium-dependent protein binding IEA --
genes like me logo Genes that share ontologies with HNRNPM: view
genes like me logo Genes that share phenotypes with HNRNPM: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPM Gene

Localization for HNRNPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPM Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPM Gene COMPARTMENTS Subcellular localization image for HNRNPM gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
cytosol 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HNRNPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0016020 membrane IDA 19946888
GO:0031012 extracellular matrix IEA,IDA 23658023
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with HNRNPM: view

Pathways & Interactions for HNRNPM Gene

genes like me logo Genes that share pathways with HNRNPM: view

Pathways by source for HNRNPM Gene

1 KEGG pathway for HNRNPM Gene

Gene Ontology (GO) - Biological Process for HNRNPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990831 cellular response to carcinoembryonic antigen IEA --
genes like me logo Genes that share ontologies with HNRNPM: view

No data available for SIGNOR curated interactions for HNRNPM Gene

Drugs & Compounds for HNRNPM Gene

No Compound Related Data Available

Transcripts for HNRNPM Gene

Unigene Clusters for HNRNPM Gene

Heterogeneous nuclear ribonucleoprotein M:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPM Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5:
SP6:

Relevant External Links for HNRNPM Gene

GeneLoc Exon Structure for
HNRNPM
ECgene alternative splicing isoforms for
HNRNPM

Expression for HNRNPM Gene

mRNA expression in normal human tissues for HNRNPM Gene

Protein differential expression in normal tissues from HIPED for HNRNPM Gene

This gene is overexpressed in Bone (21.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPM Gene



SOURCE GeneReport for Unigene cluster for HNRNPM Gene Hs.465808

genes like me logo Genes that share expression patterns with HNRNPM: view

Protein tissue co-expression partners for HNRNPM Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPM Gene

Orthologs for HNRNPM Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HNRNPM 35
  • 95.3 (n)
  • 99.32 (a)
-- 36
  • 78 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Hnrnpm 35
  • 93.02 (n)
  • 97.63 (a)
Hnrnpm 16
Hnrnpm 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HNRNPM 35
  • 99.59 (n)
  • 100 (a)
HNRNPM 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnpm 35
  • 93.06 (n)
  • 98.18 (a)
dog
(Canis familiaris)
Mammalia HNRNPM 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves HNRNPM 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1972 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5477 35
zebrafish
(Danio rerio)
Actinopterygii wufa10g07 35
hnrnpm 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta rump 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C25A1.4 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GBP2 36
  • 23 (a)
ManyToMany
HRB1 36
  • 20 (a)
ManyToMany
GBP2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7224 36
  • 36 (a)
OneToMany
Species with no ortholog for HNRNPM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPM Gene

ENSEMBL:
Gene Tree for HNRNPM (if available)
TreeFam:
Gene Tree for HNRNPM (if available)

Paralogs for HNRNPM Gene

Paralogs for HNRNPM Gene

Pseudogenes.org Pseudogenes for HNRNPM Gene

genes like me logo Genes that share paralogs with HNRNPM: view

Variants for HNRNPM Gene

Sequence variations from dbSNP and Humsavar for HNRNPM Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs6992 -- 8,488,746(+) TGTGG(C/T)GTGGT reference, synonymous-codon
rs9309 -- 8,488,866(+) GCCTT(G/T)TTTAA utr-variant-3-prime
rs628532 -- 8,465,165(-) TACCA(C/G)CTTAG intron-variant
rs635153 -- 8,452,921(-) CAAGA(C/T)TGCAG intron-variant
rs637922 -- 8,452,274(-) TCCAT(A/G)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPM Gene

Variant ID Type Subtype PubMed ID
dgv3719n71 CNV Loss 21882294
nsv911004 CNV Loss 21882294
esv2335907 CNV Deletion 18987734
esv4060 CNV Deletion 18987735
esv2718124 CNV Deletion 23290073
esv989310 CNV Deletion 20482838
esv7145 CNV Loss 19470904
esv1320041 CNV Deletion 17803354
dgv3720n71 CNV Loss 21882294
dgv3721n71 CNV Loss 21882294
nsv458350 CNV Loss 19166990
dgv396n27 CNV Loss 19166990

Variation tolerance for HNRNPM Gene

Residual Variation Intolerance Score: 4.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPM Gene

HapMap Linkage Disequilibrium report
HNRNPM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPM Gene

Disorders for HNRNPM Gene

Relevant External Links for HNRNPM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPM

No disorders were found for HNRNPM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPM Gene

Publications for HNRNPM Gene

  1. The human hnRNP M proteins: identification of a methionine/arginine- rich repeat motif in ribonucleoproteins. (PMID: 8441656) Datar K.V. … Swanson M.S. (Nucleic Acids Res. 1993) 2 3 4 67
  2. hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures. (PMID: 19874820) Marko M. … Guialis A. (Exp. Cell Res. 2010) 3 23
  3. Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. (PMID: 20467437) LlA"res D. … Lamond A.I. (EMBO Rep. 2010) 3 23
  4. Molecular cloning, cDNA analysis, and localization of a monomer of the N-acetylglucosamine-specific receptor of the thyroid, NAGR1, to chromosome 19p13.3-13.2. (PMID: 7558047) Blanck O. … Miquelis R. (Genomics 1995) 2 3
  5. Analysis of HIV-1 Gag protein interactions via biotin ligase tagging. (PMID: 25631074) Ritchie C. … Barklis E. (J. Virol. 2015) 3

Products for HNRNPM Gene

Sources for HNRNPM Gene

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