Aliases for HNRNPM Gene
Aliases for HNRNPM Gene
External Ids for HNRNPM Gene
- HGNC: 5046
- Entrez Gene: 4670
- Ensembl: ENSG00000099783
- OMIM: 160994
- UniProtKB: P52272
Previous HGNC Symbols for HNRNPM Gene
- NAGR1
- HNRPM
Previous GeneCards Identifiers for HNRNPM Gene
- GC19P008416
- GC19P008509
- GC19P008165
Summaries for HNRNPM Gene
-
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for HNRNPM Gene
HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MYEF2.
UniProtKB/Swiss-Prot for HNRNPM Gene
-
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPM Gene
Genomics for HNRNPM Gene
Regulatory Elements for HNRNPM Gene
Enhancers for HNRNPM Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HNRNPM on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HNRNPM Gene
- Chromosome:
- 19
- Start:
- 8,444,575 bp from pter
- End:
- 8,489,118 bp from pter
- Size:
- 44,544 bases
- Orientation:
- Plus strand
Genomic View for HNRNPM Gene
Genes around HNRNPM on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
HNRNPM Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPM Gene
Proteins for HNRNPM Gene
-
Protein details for HNRNPM Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P52272-HNRPM_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoprotein M
- Protein Accession:
- P52272
- Q15584
- Q8WZ44
- Q96H56
- Q9BWL9
- Q9Y492
Protein attributes for HNRNPM Gene
- Size:
- 730 amino acids
- Molecular mass:
- 77516 Da
- Quaternary structure:
-
- Identified in the spliceosome C complex.
Three dimensional structures from OCA and Proteopedia for HNRNPM Gene
Protein Expression for HNRNPM Gene
Post-translational modifications for HNRNPM Gene
- Sumoylated.
- Ubiquitination at isoforms=269, isoforms=283, isoforms=288, isoforms=2110, posLast=127127, isoforms=2345, isoforms=2381, posLast=388388, isoforms=2651, isoforms=2667, posLast=698698, and isoforms=2716
- Modification sites at PhosphoSitePlus
Other Protein References for HNRNPM Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Assay Products
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No data available for DME Specific Peptides for HNRNPM Gene
Domains & Families for HNRNPM Gene
Gene Families for HNRNPM Gene
Protein Domains for HNRNPM Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPM Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HNRNPM Gene
Function for HNRNPM Gene
Molecular function for HNRNPM Gene
- UniProtKB/Swiss-Prot Function:
- Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | NAS,IEA | 9731529 |
| GO:0005515 | protein binding | IPI | 18457437 |
| GO:0019904 | protein domain specific binding | IPI | 11984006 |
Phenotypes for HNRNPM Gene
- GenomeRNAi human phenotypes for HNRNPM:
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miRNA for HNRNPM Gene
- miRTarBase miRNAs that target HNRNPM
-
- hsa-mir-30a-5p (MIRT005120)
- hsa-mir-26b-5p (MIRT029321)
- hsa-let-7f-1-3p (MIRT038991)
- hsa-mir-615-3p (MIRT039993)
- hsa-mir-18a-3p (MIRT040906)
- hsa-mir-193b-3p (MIRT041425)
- hsa-mir-484 (MIRT042112)
- hsa-mir-331-3p (MIRT043473)
- hsa-mir-191-5p (MIRT045805)
- hsa-mir-15b-5p (MIRT046439)
- hsa-mir-183-5p (MIRT047057)
- hsa-mir-93-5p (MIRT048765)
- hsa-mir-92a-3p (MIRT049361)
- hsa-mir-29a-3p (MIRT049986)
miRNA Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPM Gene
Localization for HNRNPM Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPM Gene
- Nucleus, nucleolus.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IDA | 9731529 |
| GO:0005730 | nucleolus | IEA | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8088785 |
Pathways & Interactions for HNRNPM Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.50
.41
|
| 2 | Signaling by FGFR2 | ||
| 3 | mRNA Capping | ||
| 4 | Gene Expression |
.48
|
|
| 5 | Signaling by GPCR | ||
Pathways by source for HNRNPM Gene
1 BioSystems pathway for HNRNPM Gene
8 Reactome pathways for HNRNPM Gene
1 KEGG pathway for HNRNPM Gene
Interacting Proteins for HNRNPM Gene
Selected Interacting proteins:
P52272-HNRPM_HUMAN
ENSP00000325376
for HNRNPM Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000380 | alternative mRNA splicing, via spliceosome | IMP | 19874820 |
| GO:0000398 | mRNA splicing, via spliceosome | IEA,TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | IEA | -- |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | TAS | -- |
No data available for SIGNOR curated interactions for HNRNPM Gene
Transcripts for HNRNPM Gene
mRNA/cDNA for HNRNPM Gene
- (631) Selected AceView cDNA sequences:
- (18) Additional mRNA sequences :
- (18) REFSEQ mRNAs :
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HNRNPM Gene
CRISPR Products
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| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for HNRNPM Gene
This gene is overexpressed in Bone (21.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPM Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HNRNPM Gene:
HNRNPMSOURCE GeneReport for Unigene cluster for HNRNPM Gene:
Hs.465808Evidence on tissue expression from TISSUES for HNRNPM Gene
- Nervous system(4.7)
- Liver(4.6)
- Intestine(3.3)
- Heart(3)
- Eye(2.6)
- Adrenal gland(2.5)
- Bone marrow(2.5)
- Gall bladder(2.5)
- Kidney(2.5)
- Lung(2.5)
- Lymph node(2.5)
- Muscle(2.5)
- Pancreas(2.5)
- Skin(2.5)
- Spleen(2.5)
- Stomach(2.5)
- Thyroid gland(2.5)
Primer Products
-
OriGene qPCR primer pairs for HNRNPM
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OriGene qPCR primer pairs and template standards for HNRNPM
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPM Gene
Orthologs for HNRNPM Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HNRNPM 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| HNRNPM 34 |
|
||||
| -- 35 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Hnrnpm 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hnrnpm 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HNRNPM 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | HNRNPM 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.1972 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5477 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hnrnpm 35 |
|
OneToOne | |
| wufa10g07 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | rump 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | C25A1.4 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GBP2 35 37 |
|
ManyToMany | |
| HRB1 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7224 35 |
|
OneToMany |
- Species where no ortholog for HNRNPM was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HNRNPM Gene
(5) SIMAP similar genes for HNRNPM Gene using alignment to 10 proteins:
Pseudogenes.org Pseudogenes for HNRNPM Gene
Variants for HNRNPM Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs773444733 | Likely benign | 8,445,074(+) | CGCCC(A/G)GCGTG | reference, missense, utr-variant-5-prime | |
| rs483352729 | Uncertain significance | 8,488,790(+) | CTGCC(A/G)GATGA | reference, missense | |
| rs1000002876 | -- | 8,457,897(+) | TATTA(C/G)TCTCA | intron-variant | |
| rs1000055547 | -- | 8,461,354(+) | GTTGG(A/G)ATAGG | intron-variant | |
| rs1000096369 | -- | 8,468,900(+) | ATTAC(C/T)ATATG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv137n111 | CNV | deletion | 26073780 |
| dgv1708n106 | CNV | deletion | 24896259 |
| dgv396n27 | CNV | loss | 19166990 |
| dgv6258n54 | CNV | loss | 21841781 |
| esv1320041 | CNV | deletion | 17803354 |
| esv2335907 | CNV | deletion | 18987734 |
| esv2718124 | CNV | deletion | 23290073 |
| esv3098235 | CNV | deletion | 24192839 |
| esv3555991 | CNV | deletion | 23714750 |
| esv4060 | CNV | loss | 18987735 |
| esv7145 | CNV | loss | 19470904 |
| esv989310 | CNV | deletion | 20482838 |
| nsv1071142 | CNV | deletion | 25765185 |
| nsv1148644 | CNV | deletion | 26484159 |
| nsv458350 | CNV | loss | 19166990 |
| nsv578559 | CNV | loss | 21841781 |
| nsv956596 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
4.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.44;
28.23% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HNRNPM Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HNRNPM
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPM Gene
Disorders for HNRNPM Gene
Relevant External Links for HNRNPM
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HNRNPM
No disorders were found for HNRNPM Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPM Gene
Publications for HNRNPM Gene
- The human hnRNP M proteins: identification of a methionine/arginine- rich repeat motif in ribonucleoproteins. (PMID: 8441656) Datar K.V. … Swanson M.S. (Nucleic Acids Res. 1993) 2 3 4 64
- Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. (PMID: 20467437) LlA"res D. … Lamond A.I. (EMBO Rep. 2010) 3 22 64
- hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures. (PMID: 19874820) Marko M. … Guialis A. (Exp. Cell Res. 2010) 3 22 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
- Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PMID: 15561718) Gocke C.B. … Kang J. (J. Biol. Chem. 2005) 3 4 64
Products for HNRNPM Gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPM
- Search Santa Cruz Biotechnology (SCBT) for HNRNPM siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPM
- Cyagen custom Knockout/knockin (KOKI) mouse models for HNRNPM
- VectorBuilder custom plasmid, inducible vectors for HNRNPM
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HNRNPM
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HNRNPM Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer