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HNRNPM Gene

protein-coding   GIFtS: 57
GCID: GC19P008509

Heterogeneous Nuclear Ribonucleoprotein M


(Previous symbols: NAGR1, HNRPM)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein M1 2     CEAR2
HNRPM1 2 3 5     HNRNPM42
NAGR11 2 3 5     HTGR12
CEA Receptor1 2     Heterogenous Nuclear Ribonucleoprotein M42
HnRNP M2 3     HnRNA-Binding Protein M42
HNRPM42 5     N-Acetylglucosamine Receptor 12

External Ids:    HGNC: 50461   Entrez Gene: 46702   Ensembl: ENSG000000997837   OMIM: 1609945   UniProtKB: P522723   

Export aliases for HNRNPM gene to outside databases

Previous GC identifers: GC19P008416 GC19P008165


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPM Gene:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are
associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA
metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the
nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded
by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of
the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature
GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Aug 2011)

GeneCards Summary for HNRNPM Gene:
HNRNPM (heterogeneous nuclear ribonucleoprotein M) is a protein-coding gene. Diseases associated with HNRNPM include impetigo, and treacher collins syndrome. GO annotations related to this gene include RNA binding and protein domain specific binding. An important paralog of this gene is MYEF2.

UniProtKB/Swiss-Prot: HNRPM_HUMAN, P52272
Function: Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro.
Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of
signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and
tumor necrosis factor alpha cytokines




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPM gene promoter:
         ER-alpha   RFX1   Pax-5   MyoD   NF-AT   NF-AT4   NF-AT2   NF-AT3   ZIC2/Zic2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRNPM promoter sequence
   Search Chromatin IP Primers for HNRNPM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

HNRNPM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPM gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P008509:  view genomic region     (about GC identifiers)

Start:
8,509,651 bp from pter      End:
8,553,998 bp from pter
Size:
44,348 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HNRPM_HUMAN, P52272 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein M  
Size: 730 amino acids; 77516 Da
Subunit: Identified in the spliceosome C complex
4 PDB 3D structures from and Proteopedia for HNRNPM:
2DGV (3D)        2DH9 (3D)        2DO0 (3D)        2OT8 (3D)    
Secondary accessions: Q15584 Q8WZ44 Q96H56 Q9BWL9 Q9Y492
Alternative splicing: 3 isoforms:  P52272-1   P52272-2   P52272-3   

Explore the universe of human proteins at neXtProt for HNRNPM: NX_P52272

Explore proteomics data for HNRNPM at MOPED

Post-translational modifications: 

  • Sumoylated1
  • Ubiquitination2 at Lys69, Lys83, Lys88, Lys110, Lys127, Lys345, Lys381, Lys388, Lys651, Lys667,
                                 Lys698, Lys716
  • Modification sites at PhosphoSitePlus

  • See HNRNPM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005959.2  NP_112480.2  

    ENSEMBL proteins: 
     ENSP00000325732   ENSP00000325376   ENSP00000470932   ENSP00000471530   ENSP00000472789  
     ENSP00000470017   ENSP00000471339   ENSP00000469906   ENSP00000470635   ENSP00000472599  
     ENSP00000469681  
    Reactome Protein details: P52272

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR024666 HnRNP_M_PY-NLS
     IPR012677 Nucleotide-bd_a/b_plait
     IPR024667 HnRNP_M
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P52272

    ProtoNet protein and cluster: P52272

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: HNRPM_HUMAN, P52272
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    HNRNPM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRPM_HUMAN, P52272
    Function: Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro.
    Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of
    signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and
    tumor necrosis factor alpha cytokines

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding NAS9731529
    GO:0005515protein binding IPI19874820
    GO:0019904protein domain specific binding IPI11984006
         
    HNRNPM for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for HNRNPM:
     Decreased homologous recombina  Decreased viability  Decreased viability of wild-ty  G0/1 arrest 
     Increased G1 DNA content  Synthetic lethal with Ras 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target HNRNPM:
    hsa-let-7f-1-3p (MIRT038991), hsa-mir-183-5p (MIRT047057), hsa-mir-18a-3p (MIRT040906), hsa-mir-26b-5p (MIRT029321), hsa-mir-30a-5p (MIRT005120), hsa-mir-191-5p (MIRT045805), hsa-mir-484 (MIRT042112), hsa-mir-92a-3p (MIRT049361), hsa-mir-15b-5p (MIRT046439), hsa-mir-93-5p (MIRT048765), hsa-mir-615-3p (MIRT039993), hsa-mir-29a-3p (MIRT049986), hsa-mir-331-3p (MIRT043473), hsa-mir-193b-3p (MIRT041425)

    Block miRNA regulation of human, mouse, rat HNRNPM using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate HNRNPM:
    hsa-miR-505 hsa-miR-522 hsa-miR-224* hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPM 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HNRNPM

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    Sino Biological Human cDNA Clone for HNRNPM
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HNRPM_HUMAN, P52272: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    cytosol2
    chloroplast1
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005730NOT nucleolus IDA--
    GO:0005887integral component of plasma membrane TAS8088785

    HNRNPM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPM About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HNRNPM
        mRNA processing


    2 Reactome Pathways for HNRNPM
        mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA


    1 Kegg Pathway  (Kegg details for HNRNPM):
        Spliceosome


    HNRNPM for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPM
    Interactions:

        Search GeneGlobe Interaction Network for HNRNPM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPM (P522721, 2, 3 ENSP000003253764) via UniProtKB, MINT, STRING, and/or I2D (see all 993)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLRG1O436601, 2, 3, ENSP000003031914EBI-486809,EBI-1051504 MINT-7979397 MINT-7979468 MINT-7945693 MINT-7979389 MINT-7979545 MINT-7947479 MINT-7979423 I2D: score=1 STRING: ENSP00000303191
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62730 MINT-62632 MINT-62806 I2D: score=5 STRING: ENSP00000387477
    ENSG00000231825P486342, 3, ENSP000004153634MINT-62730 MINT-62632 MINT-62806 I2D: score=5 STRING: ENSP00000415363
    ENSG00000206427P486342, 3MINT-62730 MINT-62632 MINT-62806 I2D: score=5 
    ENSG00000225164P486342, 3MINT-62730 MINT-62632 MINT-62806 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000380alternative mRNA splicing, via spliceosome IMP19874820
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    HNRNPM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPM (HNRPM)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HNRNPM gene (2 alternative transcripts): 
    NM_005968.4  NM_031203.3  

    Unigene Cluster for HNRNPM:

    Heterogeneous nuclear ribonucleoprotein M
    Hs.465808  [show with all ESTs]
    Unigene Representative Sequence: NM_005968
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348943(uc010xke.1 uc010dwd.3) ENST00000597813 ENST00000325495(uc010dwc.1 uc010dwe.3 uc002mka.3)
    ENST00000600092 ENST00000600806 ENST00000594907 ENST00000596984 ENST00000601645
    ENST00000593293 ENST00000598367 ENST00000597270 ENST00000597081 ENST00000598603
    ENST00000596295 ENST00000598999 ENST00000602219
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate HNRNPM:
    hsa-miR-505 hsa-miR-522 hsa-miR-224* hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPM 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): HNRNPM (NM_031203)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HNRNPM
      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPM
      QuantiFast Probe-based Assays in human, mouse, rat HNRNPM

    Additional mRNA sequence: 

    AB209733.1 AF061832.1 AK022050.1 AK093731.1 AK309659.1 AL713781.1 BC000138.2 BC008895.2 
    BC018916.2 BC019580.1 BC054874.1 BC058893.1 BC064588.1 L03532.1 L32611.1 X72018.1 

    Selected DOTS entries (see all 34):

    DT.86774695  DT.100877267  DT.95104294  DT.121464677  DT.91906913  DT.40133085  DT.97766622  DT.100639213 
    DT.449272  DT.100877266  DT.431984  DT.95104225  DT.91775205  DT.100761755  DT.121464683  DT.95104288 
    DT.100877250  DT.121464713  DT.121464745  DT.40268042  DT.91785734  DT.100722499  DT.100877252  DT.121464666 

    Selected AceView cDNA sequences (see all 631):

    AA504272 BU166265 CD106412 CA426138 AW150701 H68143 BM846344 BG391938 
    AI968560 BU193228 BM783414 BQ219428 BQ929635 BG055291 CB216877 AA504208 
    BG698751 AA648812 AI444976 BG027888 BF367545 AA335700 BU190828 H90669 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPM (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
    SP1:                                                  -     -                 -                             -                                       
    SP2:                    -                             -     -                 -           -                 -                                       
    SP3:                                                  -     -                 -                             -     -                                 
    SP4:                                                                          -                                                                     
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for HNRNPM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCAGCAGCT
    HNRNPM Expression
    About this image


    HNRNPM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Secondary Spermatocyte Seminiferous Tubules
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
    HNRNPM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465808
        Custom PCR Arrays for HNRNPM
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HNRNPM gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpm1 , 5 heterogeneous nuclear ribonucleoprotein M1, 5 93.02(n)1
    97.63(a)1
      17 (17.98 cM)5
    769361  NM_029804.31  NP_084080.11 
     336462335 
    chicken
    (Gallus gallus)
    Aves HNRNPM6
    Gallus gallus heterogeneous nuclear ribonucleoprot...
    75(a)
    1 ↔ 1
    28(509129-534490)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.54772 Xenopus laevis transcribed sequence with moderate similarity more 73.36(n)    BU907390.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa10g072 wufa10g07 74.17(n)   334958  CA474897.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rump6
    rumpelstiltskin
    28(a)
    1 → many
    3R(5331575-5336087)
    worm
    (Caenorhabditis elegans)
    Secernentea C25A1.46
    Protein C25A1.4 (C25A1.4) mRNA, complete cds
    33(a)
    1 → many
    I(10169636-10172645) WBGene00007706
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GBP2(YCL011C)4 Poly(A+) RNA-binding protein, involved in the export more   --   3(103358-102075) 850346  NP_009916.1 


    ENSEMBL Gene Tree for HNRNPM (if available)
    TreeFam Gene Tree for HNRNPM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPM gene
    MYEF22  
    5 SIMAP similar genes for HNRNPM using alignment to 10 protein entries:     HNRPM_HUMAN (see all proteins):
    HNRPM    ORF    ELAVL2    MYEF2    RBMY1A1

    HNRNPM for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HNRNPM
    PGOHUM00000246772 PGOHUM00000234727


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPM (see all 1135)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107963301,2
    C,F,A,H--8444320(+) tgtgcG/Acctgt 2 -- us2k113Minor allele frequency- A:0.26NA WA CSA EA 265
    rs1131794191,2
    C,F--8444409(+) GCCACC/TGCACT 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1897558781,2
    --8444412(+) ACTGCA/CCTCCA 2 -- us2k10--------
    rs81057701,2
    C,F,H--8444518(+) caatcC/Gcagca 2 -- us2k19Minor allele frequency- G:0.10NA WA CSA 21
    rs1823690851,2
    --8444711(+) TGCAGC/TGAGCC 2 -- us2k10--------
    rs171604891,2
    C,F,H--8444872(+) TGGAGG/ACTGCA 2 -- us2k124Minor allele frequency- A:0.50NA EA NS WA 2560
    rs778247171,2
    C,F--8444943(+) TAGTAC/TAGAAT 2 -- us2k12Minor allele frequency- T:0.08WA NA 238
    rs734996151,2
    C,F--8445028(+) TTTTTT/CTGAGA 2 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1870412761,2
    C--8445367(+) AGGTTG/TGTTAA 2 -- us2k10--------
    rs1419991191,2
    --8445517(+) ATCTCA/GGCTCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HNRNPM (8509651 - 8553998 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HNRNPM (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718124CNV Deletion23290073
    esv1320041CNV Deletion17803354
    esv2335907CNV Deletion18987734
    esv989310CNV Deletion20482838
    esv4060CNV Deletion18987735
    dgv3721n71CNV Loss21882294
    nsv911004CNV Loss21882294
    dgv396n27CNV Loss19166990
    dgv3719n71CNV Loss21882294
    dgv3720n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPM
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 160994    OMIM disorders: --

    13 diseases for HNRNPM:    
    About MalaCards
    impetigo    treacher collins syndrome    tonsillitis    thyroiditis
    prostatitis    hiv-1    prostate cancer    multiple myeloma
    myeloma    breast cancer    cerebritis    malaria
    endotheliitis


    HNRNPM for disorders           About GeneDecksing


    Export disorders for HNRNPM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPM gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with HNRNPM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human hnRNP M proteins: identification of a methionine/arginine- rich repeat motif in ribonucleoproteins. (PubMed id 8441656)1, 2, 3 Datar K.V.... Swanson M.S. (Nucleic Acids Res. 1993)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (J. Biol. Chem. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    6. The human hnRNP-M proteins: structure and relation with early heat shock-induced splicing arrest and chromosome mapping. (PubMed id 8692693)1, 2 Gattoni R....Fuchs J.-P. (Nucleic Acids Res. 1996)
    7. Molecular cloning, cDNA analysis, and localization of a monomer of the N-acetylglucosamine-specific receptor of the thyroid, NAGR1, to chromosome 19p13.3-13.2. (PubMed id 7558047)1, 3 Blanck O.... Miquelis R. (Genomics 1995)
    8. hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures. (PubMed id 19874820)1, 9 Marko M....Guialis A. (Exp. Cell Res. 2010)
    9. Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. (PubMed id 20467437)1, 9 LlA"res D....Lamond A.I. (EMBO Rep. 2010)
    10. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4670 HGNC: 5046 AceView: HNRPM Ensembl:ENSG00000099783 euGenes: HUgn4670
    ECgene: HNRNPM Kegg: 4670 H-InvDB: HNRNPM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HNRNPM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPM gene:
    Search GeneIP for patents involving HNRNPM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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