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HNRNPLL Gene

protein-coding   GIFtS: 41
GCID: GC02M038790

Heterogeneous Nuclear Ribonucleoprotein L-Like


(Previous symbol: HNRPLL)
  See HNRNPLL-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein L-Like1 2
HNRPLL1 2 3 5
SRRF2 3 5
Stromal RNA-Regulating Factor2 3
Stromal RNA Regulating Factor2
hnRNPLL3

External Ids:    HGNC: 251271   Entrez Gene: 929062   Ensembl: ENSG000001438897   OMIM: 6112085   UniProtKB: Q8WVV93   

Export aliases for HNRNPLL gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPLL Gene:
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters
splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation
(Oberdoerffer et al., 2008 (PubMed 18669861)).(supplied by OMIM, Aug 2008)

GeneCards Summary for HNRNPLL Gene:
HNRNPLL (heterogeneous nuclear ribonucleoprotein L-like) is a protein-coding gene. Diseases associated with HNRNPLL include t cell deficiency. GO annotations related to this gene include mRNA binding and nucleotide binding. An important paralog of this gene is ENSG00000268083.

UniProtKB/Swiss-Prot: HNRLL_HUMAN, Q8WVV9
Function: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs,
including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for HNRNPLL
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRNPLL promoter sequence
   Search Chromatin IP Primers for HNRNPLL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPLL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22

HNRNPLL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPLL gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M038790:  view genomic region     (about GC identifiers)

Start:
38,789,120 bp from pter      End:
38,830,728 bp from pter
Size:
41,609 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HNRLL_HUMAN, Q8WVV9 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein L-like  
Size: 542 amino acids; 60083 Da
Subunit: Interacts with HNRNPL
Secondary accessions: Q53T80 Q5JB51 Q659B9 Q8IVH5 Q8IVH6 Q96HR5
Alternative splicing: 4 isoforms:  Q8WVV9-1   Q8WVV9-2   Q8WVV9-3   Q8WVV9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HNRNPLL: NX_Q8WVV9

Explore proteomics data for HNRNPLL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys71, Lys261
  • Modification sites at PhosphoSitePlus

  • See HNRNPLL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136122.1  NP_612403.2  

    ENSEMBL proteins: 
     ENSP00000390625   ENSP00000387088   ENSP00000272249   ENSP00000386575   ENSP00000415766  
     ENSP00000386695   ENSP00000396669   ENSP00000476852   ENSP00000368195   ENSP00000351136  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR006536 HnRNP-L_PTB
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q8WVV9

    ProtoNet protein and cluster: Q8WVV9

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB000634 Serine/threonine dehydratase


    UniProtKB/Swiss-Prot: HNRLL_HUMAN, Q8WVV9
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    Find genes that share domains with HNRNPLL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRLL_HUMAN, Q8WVV9
    Function: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs,
    including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC
    Induction: Up-regulated in stimulated T-cells

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003729mRNA binding IDA18669861
    GO:0005515protein binding IPI18669861
         
    Find genes that share ontologies with HNRNPLL           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hnrpll):
     hematopoietic system  immune system 

    Find genes that share phenotypes with HNRNPLL           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HNRNPLL
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    Predesigned siRNA for gene silencing in human, mouse, rat HNRNPLL

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0019013viral nucleocapsid ----
    GO:0030529ribonucleoprotein complex IEA--

    Find genes that share ontologies with HNRNPLL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPLL About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control


    Find genes that share SuperPaths with HNRNPLL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HNRNPLL
        Translational Control


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPLL
    Interactions:

        Search GeneGlobe Interaction Network for HNRNPLL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for HNRNPLL (Q8WVV92, 3 ENSP000003870884) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225073Q138382, 3, ENSP000004003264MINT-62644 MINT-62818 MINT-62742 I2D: score=4 STRING: ENSP00000400326
    ENSG00000215425Q138382, 3MINT-62644 MINT-62818 MINT-62742 I2D: score=4 
    ENSG00000225859Q138382, 3MINT-62644 MINT-62818 MINT-62742 I2D: score=4 
    ENSG00000229496Q138382, 3MINT-62644 MINT-62818 MINT-62742 I2D: score=4 
    ENSG00000230624Q138382, 3MINT-62644 MINT-62818 MINT-62742 I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0033120positive regulation of RNA splicing IDA18669861

    Find genes that share ontologies with HNRNPLL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPLL (HNRLL)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HNRNPLL gene (2 alternative transcripts): 
    NM_001142650.1  NM_138394.3  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449105(uc021vgc.1) ENST00000409636(uc002rqv.3 uc021vgb.1)
    ENST00000272249 ENST00000409328 ENST00000441689 ENST00000410076 ENST00000488099
    ENST00000425682 ENST00000498516 ENST00000608859 ENST00000378915 ENST00000358367

    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPLL
      QuantiFast Probe-based Assays in human, mouse, rat HNRNPLL

    Selected AceView cDNA sequences (see all 170):

    AL512692 CB216871 AI097117 BM680747 BM798744 CB529631 AA772017 AI159865 
    BQ218989 AA600090 CA395569 AI884490 AA759359 AK000155 AI638152 BF438351 
    AW474947 AI307220 AI302235 NM_138394 BM718873 BM981493 BC008217 AI655053 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPLL    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                    -                                         -     -                                             
    SP2:                    -                             -           -     -                                             
    SP3:                                                              -                                                   
    SP4:                    -                                                                                             
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for HNRNPLL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPLL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HNRNPLL Expression
    About this image

    HNRNPLL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPLL Protein Expression

    UniProtKB/Swiss-Prot: HNRLL_HUMAN, Q8WVV9
    Tissue specificity: Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta,
    pancreas, kidney and lung

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HNRNPLL gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrpll5
    Hnrnpll1
    heterogeneous nuclear ribonucleoprotein L-like1, 5 90.87(n)1
    95.5(a)1
      17 (50.30 cM)5
    726921  NM_144802.31  NP_659051.31 
     800294875 
    chicken
    (Gallus gallus)
    Aves HNRPLL1 heterogeneous nuclear ribonucleoprotein L-like 84.74(n)
    97.71(a)
      416702  XM_414998.4  XP_414998.4 
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPLL6
    heterogeneous nuclear ribonucleoprotein L-like
    85(a)
    1 ↔ 1
    1(254075161-254093780)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hnrnpll1 heterogeneous nuclear ribonucleoprotein L-like 77.12(n)
    87.12(a)
      100151733  NM_001127432.1  NP_001120904.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sm6
    smooth
    33(a)
    1 → many
    2R(15405369-15519013)
    worm
    (Caenorhabditis elegans)
    Secernentea C44B7.26
    Protein C44B7.2, isoform b (C44B7.2) mRNA, complet...
    31(a)
    1 → many
    II(6898680-6901792) WBGene00016624


    ENSEMBL Gene Tree for HNRNPLL (if available)
    TreeFam Gene Tree for HNRNPLL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPLL gene
    ENSG000002680832  PTBP12  PTBP32  PTBP22  HNRNPL2  
    2 SIMAP similar genes for HNRNPLL using alignment to 6 protein entries:     HNRLL_HUMAN (see all proteins):
    HNRPLL    HNRNPL

    Find genes that share paralogs with HNRNPLL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPLL (see all 997)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831602521,2
    --38789954(+) TTCCAC/TCTAAA 2 -- int10--------
    rs1383154871,2
    --38789992(+) AAATGC/TCTGCC 2 -- int10--------
    rs101714131,2
    C,F--38790118(+) TGTCAA/GCTACT 2 -- int11Minor allele frequency- G:0.04WA 118
    rs777917011,2
    C,F--38790122(+) AACTAT/CTGATA 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs1887932961,2
    --38790175(+) AAGATA/GAAAAC 2 -- int10--------
    rs1929351861,2
    --38790257(+) ATACCA/CTGTTT 2 -- int10--------
    rs2017169921,2
    C--38790270(+) TCCTT-/AAATCT 2 -- int10--------
    rs1471035961,2
    C--38790311(+) AAAAG-/AAAAAA 2 -- int10--------
    rs1443368991,2
    C--38790436(+) ACATAA/TTACTG 2 -- ut310--------
    rs1177723511,2
    F--38790450(+) GATCCA/TAGAGT 2 -- ut311Minor allele frequency- T:0.02EA 120

    HapMap Linkage Disequilibrium report for HNRNPLL (38789120 - 38830728 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HNRNPLL: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPLL
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPLL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611208    OMIM disorders: --

    1 disease for HNRNPLL:    
    About MalaCards
    t cell deficiency


    Find genes that share disorders with HNRNPLL           About GenesLikeMe


    Export disorders for HNRNPLL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPLL gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with HNRNPLL)
        Utopia: connect your pdf to the dynamic
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    1. Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. (PubMed id 18669861)1, 2, 3, 9 Oberdoerffer S....Rao A. (Science 2008)
    2. Alternatively spliced isoforms of a novel stromal RNA regulating factor. (PubMed id 15256261)1, 2, 9 Shur I.... Benayahu D. (Gene 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Proteomic dissection of the von Hippel-Lindau (VHL) interactome. (PubMed id 21942715)1 Lai Y....Shiio Y. (J. Proteome Res. 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92906 HGNC: 25127 AceView: LOC92906 Ensembl:ENSG00000143889 euGenes: HUgn92906
    ECgene: HNRNPLL H-InvDB: HNRNPLL

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HNRNPLL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPLL gene:
    Search GeneIP for patents involving HNRNPLL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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