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Aliases for HNRNPLL Gene

Aliases for HNRNPLL Gene

  • Heterogeneous Nuclear Ribonucleoprotein L-Like 2 3
  • HNRPLL 3 4 6
  • SRRF 3 4 6
  • Stromal RNA-Regulating Factor 3 4
  • Stromal RNA Regulating Factor 3
  • HnRNPLL 4

External Ids for HNRNPLL Gene

Previous HGNC Symbols for HNRNPLL Gene

  • HNRPLL

Previous GeneCards Identifiers for HNRNPLL Gene

  • GC02M038790

Summaries for HNRNPLL Gene

Entrez Gene Summary for HNRNPLL Gene

  • HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]

GeneCards Summary for HNRNPLL Gene

HNRNPLL (Heterogeneous Nuclear Ribonucleoprotein L-Like) is a Protein Coding gene. Diseases associated with HNRNPLL include t cell deficiency. Among its related pathways are Translational Control. GO annotations related to this gene include nucleotide binding and mRNA binding. An important paralog of this gene is ENSG00000268083.

UniProtKB/Swiss-Prot for HNRNPLL Gene

  • RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPLL Gene

Genomics for HNRNPLL Gene

Genomic Location for HNRNPLL Gene

Start:
38,561,978 bp from pter
End:
38,603,586 bp from pter
Size:
41,609 bases
Orientation:
Minus strand

Genomic View for HNRNPLL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPLL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPLL Gene

No data available for Regulatory Elements for HNRNPLL Gene

Proteins for HNRNPLL Gene

  • Protein details for HNRNPLL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVV9-HNRLL_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein L-like
    Protein Accession:
    Q8WVV9
    Secondary Accessions:
    • Q53T80
    • Q5JB51
    • Q5JB52
    • Q659B9
    • Q8IVH5
    • Q8IVH6
    • Q96HR5

    Protein attributes for HNRNPLL Gene

    Size:
    542 amino acids
    Molecular mass:
    60083 Da
    Quaternary structure:
    • Interacts with HNRNPL.

    Alternative splice isoforms for HNRNPLL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPLL Gene

Proteomics data for HNRNPLL Gene at MOPED

Post-translational modifications for HNRNPLL Gene

  • Ubiquitination at Lys71 and Lys261
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPLL Gene

Domains for HNRNPLL Gene

Gene Families for HNRNPLL Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Graphical View of Domain Structure for InterPro Entry

Q8WVV9

UniProtKB/Swiss-Prot:

HNRLL_HUMAN :
  • Q8WVV9
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPLL: view

No data available for Suggested Antigen Peptide Sequences for HNRNPLL Gene

Function for HNRNPLL Gene

Molecular function for HNRNPLL Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
UniProtKB/Swiss-Prot Induction: Up-regulated in stimulated T-cells.

Gene Ontology (GO) - Molecular Function for HNRNPLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0003729 mRNA binding IDA 18669861
GO:0005515 protein binding IPI 18669861
genes like me logo Genes that share ontologies with HNRNPLL: view

Phenotypes for HNRNPLL Gene

genes like me logo Genes that share phenotypes with HNRNPLL: view

Animal Model Products

CRISPR Products

miRNA for HNRNPLL Gene

miRTarBase miRNAs that target HNRNPLL

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPLL Gene

Localization for HNRNPLL Gene

Gene Ontology (GO) - Cellular Components for HNRNPLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IDA 19946888
GO:0019013 viral nucleocapsid --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with HNRNPLL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for HNRNPLL Gene

Pathways for HNRNPLL Gene

SuperPathways for HNRNPLL Gene

Superpath Contained pathways
1 Translational Control
genes like me logo Genes that share pathways with HNRNPLL: view

Pathways by source for HNRNPLL Gene

1 Cell Signaling Technology pathway for HNRNPLL Gene

Gene Ontology (GO) - Biological Process for HNRNPLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0033120 positive regulation of RNA splicing IDA 18669861
genes like me logo Genes that share ontologies with HNRNPLL: view

Transcripts for HNRNPLL Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPLL

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPLL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for HNRNPLL Gene

GeneLoc Exon Structure for
HNRNPLL
ECgene alternative splicing isoforms for
HNRNPLL

Expression for HNRNPLL Gene

mRNA expression in normal human tissues for HNRNPLL Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPLL Gene

mRNA Expression by UniProt/SwissProt for HNRNPLL Gene

Q8WVV9-HNRLL_HUMAN
Tissue specificity: Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung.
genes like me logo Genes that share expressions with HNRNPLL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HNRNPLL Gene

Orthologs for HNRNPLL Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPLL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPLL 36
  • 100 (a)
OneToOne
HNRPLL 35
  • 99.31 (n)
  • 99.63 (a)
cow
(Bos Taurus)
Mammalia HNRNPLL 36
  • 98 (a)
OneToOne
HNRPLL 35
  • 96 (n)
  • 99.82 (a)
dog
(Canis familiaris)
Mammalia HNRNPLL 35
  • 96.31 (n)
  • 99.82 (a)
HNRNPLL 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpll 35
  • 90.87 (n)
  • 95.5 (a)
Hnrnpll 36
  • 87 (a)
OneToOne
Hnrpll 16
oppossum
(Monodelphis domestica)
Mammalia HNRNPLL 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPLL 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnpll 35
  • 90.34 (n)
  • 94.83 (a)
chicken
(Gallus gallus)
Aves HNRNPLL 36
  • 97 (a)
OneToOne
HNRPLL 35
  • 84.74 (n)
  • 97.71 (a)
lizard
(Anolis carolinensis)
Reptilia HNRNPLL 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpll 35
  • 77.12 (n)
  • 87.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta sm 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C44B7.2 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for HNRNPLL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HNRNPLL Gene

ENSEMBL:
Gene Tree for HNRNPLL (if available)
TreeFam:
Gene Tree for HNRNPLL (if available)

Paralogs for HNRNPLL Gene

Paralogs for HNRNPLL Gene

Selected SIMAP similar genes for HNRNPLL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HNRNPLL: view

Variants for HNRNPLL Gene

Sequence variations from dbSNP and Humsavar for HNRNPLL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs438564 -- 38,601,695(+) TCATG(A/G)GGCAA intron-variant
rs442831 -- 38,604,370(-) GACAG(C/G)CGGTG upstream-variant-2KB
rs919633 -- 38,601,306(+) ttttt(C/T)ttatt intron-variant
rs969876 -- 38,574,105(+) CACAC(A/T)CAAAT intron-variant
rs1249115 -- 38,594,755(+) gatca(A/G)cctgg intron-variant

Relevant External Links for HNRNPLL Gene

HapMap Linkage Disequilibrium report
HNRNPLL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HNRNPLL Gene

Disorders for HNRNPLL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HNRNPLL Gene including...

Search for HNRNPLL Gene in MalaCards »
genes like me logo Genes that share disorders with HNRNPLL: view

No data available for UniProtKB/Swiss-Prot for HNRNPLL Gene

Publications for HNRNPLL Gene

  1. Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. (PMID: 18669861) Oberdoerffer S. … Rao A. (Science 2008) 2 3 4 23
  2. Alternatively spliced isoforms of a novel stromal RNA regulating factor. (PMID: 15256261) Shur I. … Benayahu D. (Gene 2004) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Nucleolar proteome dynamics. (PMID: 15635413) Andersen J.S. … Mann M. (Nature 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for HNRNPLL Gene

  • antibodies-online peptides for HNRNPLL
  • antibodies-online antibodies for HNRNPLL
  • antibodies-online kits for HNRNPLL

Sources for HNRNPLL Gene

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