Aliases for HNRNPLL Gene
Aliases for HNRNPLL Gene
External Ids for HNRNPLL Gene
- HGNC: 25127
- Entrez Gene: 92906
- Ensembl: ENSG00000143889
- OMIM: 611208
- UniProtKB: Q8WVV9
Previous HGNC Symbols for HNRNPLL Gene
- HNRPLL
Previous GeneCards Identifiers for HNRNPLL Gene
- GC02M038790
Summaries for HNRNPLL Gene
-
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]
GeneCards Summary for HNRNPLL Gene
HNRNPLL (Heterogeneous Nuclear Ribonucleoprotein L Like) is a Protein Coding gene. Diseases associated with HNRNPLL include T Cell Deficiency. Among its related pathways are Translational Control. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPL.
UniProtKB/Swiss-Prot for HNRNPLL Gene
-
RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPLL Gene
Genomics for HNRNPLL Gene
Regulatory Elements for HNRNPLL Gene
Enhancers for HNRNPLL Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HNRNPLL on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HNRNPLL Gene
- Chromosome:
- 2
- Start:
- 38,561,978 bp from pter
- End:
- 38,603,586 bp from pter
- Size:
- 41,609 bases
- Orientation:
- Minus strand
Genomic View for HNRNPLL Gene
Genes around HNRNPLL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p22.1 by Ensembl
- 2p22.1 by Entrez Gene
- 2p22.1 by HGNC
HNRNPLL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPLL Gene
Proteins for HNRNPLL Gene
-
Protein details for HNRNPLL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WVV9-HNRLL_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoprotein L-like
- Protein Accession:
- Q8WVV9
- Q53T80
- Q5JB51
- Q5JB52
- Q659B9
- Q8IVH5
- Q8IVH6
- Q96HR5
Protein attributes for HNRNPLL Gene
- Size:
- 542 amino acids
- Molecular mass:
- 60083 Da
- Quaternary structure:
-
- Interacts with HNRNPL.
Protein Expression for HNRNPLL Gene
Post-translational modifications for HNRNPLL Gene
Other Protein References for HNRNPLL Gene
Antibody Products
- Cell Signaling Technology (CST) Antibodies for HNRNPLL (HNRPLL)
- Novus Biologicals Antibodies for HNRNPLL
-
Abcam antibodies for HNRNPLL
- Invitrogen Antibodies for HNRNPLL
- antibodies-online Antibodies for HNRNPLL: See all 41
- GeneTex HNRNPLL antibody for HNRNPLL
-
Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPLL
Protein Products
-
OriGene Purified Proteins for HNRNPLL
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- Search GeneTex for Proteins for HNRNPLL
Assay Products
- antibodies-online Kits for HNRNPLL: See all 21
No data available for DME Specific Peptides for HNRNPLL Gene
Domains & Families for HNRNPLL Gene
Gene Families for HNRNPLL Gene
Protein Domains for HNRNPLL Gene
Suggested Antigen Peptide Sequences for HNRNPLL Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HNRNPLL Gene
Function for HNRNPLL Gene
Molecular function for HNRNPLL Gene
- UniProtKB/Swiss-Prot Function:
- RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in stimulated T-cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,IDA | 22658674 |
| GO:0003729 | mRNA binding | IDA | 18669861 |
| GO:0005515 | protein binding | IPI | 18669861 |
Phenotypes for HNRNPLL Gene
- MGI mutant phenotypes for HNRNPLL:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HNRNPLL:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Increased transcriptional activity
- Decreased shRNA abundance (Z-score < -2)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPLL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPLL gene
- Search ViGene Biosciences for HNRNPLL
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPLL
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPLL
- GenScript: Design CRISPR guide RNA sequences for HNRNPLL
miRNA for HNRNPLL Gene
- miRTarBase miRNAs that target HNRNPLL
miRNA Products
- Search ViGene Biosciences for HNRNPLL
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HNRNPLL
- Browse OriGene Inhibitory RNA Products For HNRNPLL
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPLL gene
Clone Products
- Sino Biological Human cDNA Clone for HNRNPLL
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Cell Line Products
-
Horizon Cell Lines for HNRNPLL
-
ViGene Biosciences adenoviral particle packaged cDNA for HNRNPLL gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPLL gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPLL Gene
Localization for HNRNPLL Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| mitochondrion | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0016020 | membrane | IDA | 19946888 |
| GO:0019013 | viral nucleocapsid | IEA | -- |
| GO:0030529 | intracellular ribonucleoprotein complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for HNRNPLL Gene
Pathways & Interactions for HNRNPLL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Translational Control | ||
Pathways by source for HNRNPLL Gene
1 Cell Signaling Technology pathway for HNRNPLL Gene
Interacting Proteins for HNRNPLL Gene
Selected Interacting proteins:
ENSP00000387088
Q8WVV9-HNRLL_HUMAN
for HNRNPLL Gene via
STRING
IID
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0033120 | positive regulation of RNA splicing | IDA | 18669861 |
No data available for SIGNOR curated interactions for HNRNPLL Gene
Transcripts for HNRNPLL Gene
mRNA/cDNA for HNRNPLL Gene
- (6) REFSEQ mRNAs :
- (170) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPLL
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPLL
- GenScript: Design CRISPR guide RNA sequences for HNRNPLL
miRNA Products
- Search ViGene Biosciences for HNRNPLL
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HNRNPLL
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-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPLL gene
Clone Products
- Sino Biological Human cDNA Clone for HNRNPLL
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for HNRNPLL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epiblast (Early Embryonic Tissues)
- Primordial Germ Cell Precursors Epiblast
-
Gonad
- Primordial Germ Cell Precursors Epiblast
This gene is overexpressed in Peripheral blood mononuclear cells (10.9) and Fetal ovary (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPLL Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HNRNPLL Gene:
HNRNPLLmRNA Expression by UniProt/SwissProt for HNRNPLL Gene:
Q8WVV9-HNRLL_HUMAN
Tissue specificity:
Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung.
Evidence on tissue expression from TISSUES for HNRNPLL Gene
- Nervous system(4.7)
- Lymph node(4.2)
Primer Products
-
OriGene qPCR primer pairs for HNRNPLL
-
OriGene qPCR primer pairs and template standards for HNRNPLL
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPLL Gene
Orthologs for HNRNPLL Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HNRNPLL 35 |
|
OneToOne | |
| HNRPLL 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | HNRNPLL 35 |
|
OneToOne | |
| HNRPLL 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | HNRNPLL 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HNRNPLL 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hnrnpll 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hnrnpll 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HNRNPLL 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HNRNPLL 35 |
|
OneToOne | |
| HNRPLL 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | HNRNPLL 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hnrnpll 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | sm 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | C44B7.2 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HNRNPLL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for HNRNPLL Gene
(2) SIMAP similar genes for HNRNPLL Gene using alignment to 6 proteins:
Variants for HNRNPLL Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000120394 | -- | 38,564,020(+) | TTTAA(G/T)CTTAC | downstream-variant-500B, utr-variant-3-prime | |
| rs1000137908 | -- | 38,597,754(+) | CACGA(A/T)CTCAG | intron-variant | |
| rs1000246726 | -- | 38,566,942(+) | TGGGG(C/G)GACGG | intron-variant | |
| rs1000295617 | -- | 38,579,448(+) | AATAA(A/T)AATTC | intron-variant | |
| rs1000361751 | -- | 38,589,037(+) | CCCAA(A/G)TGTTG | intron-variant |
Residual Variation Intolerance Score:
9.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.00;
49.84% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HNRNPLL Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HNRNPLL
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPLL Gene
Disorders for HNRNPLL Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| t cell deficiency |
|
|
Search HNRNPLL in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HNRNPLL
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HNRNPLL
No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPLL Gene
Publications for HNRNPLL Gene
- Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. (PMID: 18669861) Oberdoerffer S. … Rao A. (Science 2008) 2 3 4 22 64
- Alternatively spliced isoforms of a novel stromal RNA regulating factor. (PMID: 15256261) Shur I. … Benayahu D. (Gene 2004) 3 4 22 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3 64
- Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
Products for HNRNPLL Gene
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- antibodies-online Antibodies for HNRNPLL: See all 41
- antibodies-online Kits for HNRNPLL: See all 21
- Search antibodies-online for proteins
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- GeneTex HNRNPLL antibody for HNRNPLL
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- ViGene Biosciences adenoviral particle packaged cDNA for HNRNPLL gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HNRNPLL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (141) ENCODE
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- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer