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Aliases for HNRNPLL Gene

Aliases for HNRNPLL Gene

  • Heterogeneous Nuclear Ribonucleoprotein L Like 2 3
  • Stromal RNA-Regulating Factor 3 4
  • HNRPLL 3 4
  • SRRF 3 4
  • Heterogeneous Nuclear Ribonucleoprotein L-Like 5
  • Stromal RNA Regulating Factor 3
  • HnRNPLL 4

External Ids for HNRNPLL Gene

Previous HGNC Symbols for HNRNPLL Gene

  • HNRPLL

Previous GeneCards Identifiers for HNRNPLL Gene

  • GC02M038790

Summaries for HNRNPLL Gene

Entrez Gene Summary for HNRNPLL Gene

  • HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]

GeneCards Summary for HNRNPLL Gene

HNRNPLL (Heterogeneous Nuclear Ribonucleoprotein L Like) is a Protein Coding gene. Diseases associated with HNRNPLL include T Cell Deficiency. Among its related pathways are Translational Control. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ENSG00000268083.

UniProtKB/Swiss-Prot for HNRNPLL Gene

  • RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPLL Gene

Genomics for HNRNPLL Gene

Regulatory Elements for HNRNPLL Gene

Enhancers for HNRNPLL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HNRNPLL on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPLL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HNRNPLL on UCSC Golden Path with GeneCards custom track

Genomic Location for HNRNPLL Gene

Chromosome:
2
Start:
38,561,978 bp from pter
End:
38,603,586 bp from pter
Size:
41,609 bases
Orientation:
Minus strand

Genomic View for HNRNPLL Gene

Genes around HNRNPLL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPLL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPLL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPLL Gene

Proteins for HNRNPLL Gene

  • Protein details for HNRNPLL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVV9-HNRLL_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein L-like
    Protein Accession:
    Q8WVV9
    Secondary Accessions:
    • Q53T80
    • Q5JB51
    • Q5JB52
    • Q659B9
    • Q8IVH5
    • Q8IVH6
    • Q96HR5

    Protein attributes for HNRNPLL Gene

    Size:
    542 amino acids
    Molecular mass:
    60083 Da
    Quaternary structure:
    • Interacts with HNRNPL.

    Alternative splice isoforms for HNRNPLL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPLL Gene

Proteomics data for HNRNPLL Gene at MOPED

Post-translational modifications for HNRNPLL Gene

  • Ubiquitination at Lys 71
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPLL Gene

Domains & Families for HNRNPLL Gene

Gene Families for HNRNPLL Gene

Suggested Antigen Peptide Sequences for HNRNPLL Gene

Graphical View of Domain Structure for InterPro Entry

Q8WVV9

UniProtKB/Swiss-Prot:

HNRLL_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPLL: view

Function for HNRNPLL Gene

Molecular function for HNRNPLL Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
UniProtKB/Swiss-Prot Induction:
Up-regulated in stimulated T-cells.

Gene Ontology (GO) - Molecular Function for HNRNPLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003729 mRNA binding IDA 18669861
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HNRNPLL: view
genes like me logo Genes that share phenotypes with HNRNPLL: view

Animal Model Products

CRISPR Products

miRNA for HNRNPLL Gene

miRTarBase miRNAs that target HNRNPLL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPLL Gene

Localization for HNRNPLL Gene

Gene Ontology (GO) - Cellular Components for HNRNPLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HNRNPLL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for HNRNPLL Gene

Pathways & Interactions for HNRNPLL Gene

SuperPathways for HNRNPLL Gene

Superpath Contained pathways
1 Translational Control
genes like me logo Genes that share pathways with HNRNPLL: view

Pathways by source for HNRNPLL Gene

1 Cell Signaling Technology pathway for HNRNPLL Gene

Gene Ontology (GO) - Biological Process for HNRNPLL Gene

None

No data available for SIGNOR curated interactions for HNRNPLL Gene

Drugs & Compounds for HNRNPLL Gene

No Compound Related Data Available

Transcripts for HNRNPLL Gene

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPLL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for HNRNPLL Gene

GeneLoc Exon Structure for
HNRNPLL
ECgene alternative splicing isoforms for
HNRNPLL

Expression for HNRNPLL Gene

mRNA expression in normal human tissues for HNRNPLL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HNRNPLL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.9) and Fetal ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPLL Gene



mRNA Expression by UniProt/SwissProt for HNRNPLL Gene

Q8WVV9-HNRLL_HUMAN
Tissue specificity: Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung.
genes like me logo Genes that share expression patterns with HNRNPLL: view

Protein tissue co-expression partners for HNRNPLL Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for HNRNPLL Gene

Orthologs for HNRNPLL Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPLL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HNRPLL 35
  • 96 (n)
  • 99.82 (a)
HNRNPLL 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPLL 35
  • 96.31 (n)
  • 99.82 (a)
HNRNPLL 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpll 35
  • 90.87 (n)
  • 95.5 (a)
Hnrnpll 16
Hnrnpll 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HNRPLL 35
  • 99.31 (n)
  • 99.63 (a)
HNRNPLL 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnpll 35
  • 90.34 (n)
  • 94.83 (a)
oppossum
(Monodelphis domestica)
Mammalia HNRNPLL 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPLL 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRPLL 35
  • 84.74 (n)
  • 97.71 (a)
HNRNPLL 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPLL 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpll 35
  • 77.12 (n)
  • 87.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta sm 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C44B7.2 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for HNRNPLL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HNRNPLL Gene

ENSEMBL:
Gene Tree for HNRNPLL (if available)
TreeFam:
Gene Tree for HNRNPLL (if available)

Paralogs for HNRNPLL Gene

Paralogs for HNRNPLL Gene

(2) SIMAP similar genes for HNRNPLL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HNRNPLL: view

Variants for HNRNPLL Gene

Sequence variations from dbSNP and Humsavar for HNRNPLL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs438564 -- 38,601,695(+) TCATG(A/G)GGCAA intron-variant
rs442831 -- 38,604,370(-) GACAG(C/G)CGGTG upstream-variant-2KB
rs1653807 -- 38,579,437(+) attaa(A/G)aaatt intron-variant
rs1653808 -- 38,582,899(+) AGGGT(A/C)CCAAA intron-variant
rs1864828 -- 38,597,639(+) TCACA(A/T)AACAG intron-variant

Variation tolerance for HNRNPLL Gene

Residual Variation Intolerance Score: 9.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for HNRNPLL Gene

Disorders for HNRNPLL Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNRNPLL Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t cell deficiency
  • t-lymphocyte deficiency
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HNRNPLL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPLL
genes like me logo Genes that share disorders with HNRNPLL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPLL Gene

Publications for HNRNPLL Gene

  1. Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. (PMID: 18669861) Oberdoerffer S. … Rao A. (Science 2008) 2 3 4 23 67
  2. Alternatively spliced isoforms of a novel stromal RNA regulating factor. (PMID: 15256261) Shur I. … Benayahu D. (Gene 2004) 3 23
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for HNRNPLL Gene

Sources for HNRNPLL Gene

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