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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNRNPL Gene

protein-coding   GIFtS: 55
GCID: GC19M039327

heterogeneous nuclear ribonucleoprotein L


(Previous symbol: HNRPL)
 Explore 14 diseases affiliated with
HNRNPL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HNRNPL    

Aliases
for HNRNPL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heterogeneous Nuclear Ribonucleoprotein L1 2
HNRPL1 2 3
HnRNP L2 3
HnRNP-L1

External Ids:    HGNC: 50451   Entrez Gene: 31912   Ensembl: ENSG000001048247   OMIM: 6030835   UniProtKB: P148663   

Export aliases for HNRNPL gene to outside databases

Previous GC identifers: GC19M044022 GC19M035773


Summaries
for HNRNPL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HNRNPL:
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific
proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among
the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a
major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is
present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the
nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the
cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that
they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HNRPL_HUMAN, P14866
Function: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide
the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the
cytoplasm. Is associated with most nascent transcripts including those of the landmark giant loops of amphibian
lampbrush chromosomes. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the
APEX2 promoter

Gene Wiki entry for HNRNPL


Genomic Views
for HNRNPL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNRNPL gene promoter:
         E2F-1   Sp1   Pax-5   E2F   p300   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HNRNPL promoter sequence
   Search SABiosciences Chromatin IP Primers for HNRNPL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

HNRNPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPL gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039327:  view genomic region     (about GC identifiers)

Start:
 39,327,028 bp from pter      End:
 39,342,979 bp from pter
Size:
 15,952 bases      Orientation:
 minus strand

Proteins
for HNRNPL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HNRPL_HUMAN, P14866 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein L  
Size: 589 amino acids; 64133 Da
Subunit: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1,
HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0,
RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with HNRPLL. Interacts with
APEX1; the interaction is DNA-dependent
Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing
untranslated mRNAs
Sequence caution: Sequence=CAA34261.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for HNRNPL:
3R27 (3D)        3TO8 (3D)    
Secondary accessions: A6ND69 A6NIT8 Q9H3P3
Alternative splicing: 2 isoforms:  P14866-1   P14866-2   

Explore the universe of human proteins at neXtProt for HNRNPL: NX_P14866

Post-translational modifications:

  • Several isoelectric forms of the L protein are probably the results of post-translational modifications1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P14866

    • HNRNPL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005335.1  NP_001524.2  

    ENSEMBL proteins: 
     ENSP00000221419   ENSP00000373401   ENSP00000373402  
    Reactome Protein details: P14866
    Human Recombinant Protein Products: 
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    Uscn Proteins for HNRNPL

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15798186
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0030529ribonucleoprotein complex IDA17289661
    GO:0030530heterogeneous nuclear ribonucleoprotein complex ----


    HNRNPL for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for HNRNPL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HNRNPL for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006536 HnRNP-L_PTB
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P14866

    ProtoNet protein and cluster: P14866

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: HNRPL_HUMAN, P14866
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    Function
    for HNRNPL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HNRPL_HUMAN, P14866
    Function: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide
    the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the
    cytoplasm. Is associated with most nascent transcripts including those of the landmark giant loops of amphibian
    lampbrush chromosomes. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the
    APEX2 promoter

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI11809897
    GO:0044212transcription regulatory region DNA binding IDA11809897


    HNRNPL for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for HNRNPL:
     Decreased viability  Increased gamma-H2AX phosphory 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hnrnpl):
     cellular  hematopoietic system  immune system  mortality/aging 

    HNRNPL for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HNRNPL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA Splicing1.00
    		mRNA Processing0.82
    		mRNA Splicing - Major Pathway1.00
    		mRNA processing0.48
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    2Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for HNRNPL 
        mRNA processing

    5        Reactome Pathways for HNRNPL
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA



    HNRNPL for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HNRNPL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/284 Interacting proteins for HNRNPL (P148662, 3 ENSP000002214194) via UniProtKB, MINT, STRING, and/or I2D (see all 284)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PJA1Q8NG272, 3, ENSP000003550144MINT-65012 I2D: score=4 STRING: ENSP00000355014
    CSE1LP550602, 3MINT-63871 I2D: score=5 
    PCBP2Q153662, 3, ENSP000003524384MINT-8198073 MINT-6488791 I2D: score=2 STRING: ENSP00000352438
    UBCP0CG482, 3, ENSP000003448184MINT-6488791 I2D: score=1 STRING: ENSP00000344818
    HMG20BQ9P0W22, 3, ENSP000003282694MINT-65669 I2D: score=5 STRING: ENSP00000328269
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006396RNA processing TAS2687284
    GO:0006397mRNA processing ----
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--


    HNRNPL for ontologies           About GeneDecksing



    Drugs & Compounds
    for HNRNPL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HNRNPL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HNRNPL
    1 Novoseek chemical compound relationship for HNRNPL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 37.8 1 16441660 (1)

    Search CenterWatch for drugs/clinical trials and news about HNRNPL / HNRPL 

    Transcripts
    for HNRNPL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HNRNPL gene (2 alternative transcripts): 
    NM_001005335.1  NM_001533.2  

    Unigene Cluster for HNRNPL:

    Heterogeneous nuclear ribonucleoprotein L
    Hs.644906  [show with all ESTs]
    Unigene Representative Sequence: AB044547
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221419(uc021uuh.1) ENST00000388749(uc002ojk.3 uc002ojl.3 uc021uui.1 uc002ojo.1)
    ENST00000388750(uc002ojj.1 uc010ege.1 uc002ojp.1 uc010xun.2)


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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB044547.1 AK292115.1 AK298384.1 AK301062.1 AK313652.1 AY927543.1 AY927544.1 BC069184.1 
    X16135.1 

    24/34 DOTS entries (see all 34):

    DT.92441002  DT.100814044  DT.95185903  DT.448398  DT.100836288  DT.92441011  DT.100814046  DT.95150508 
    DT.91690394  DT.100814042  DT.95150506  DT.100790374  DT.121453538  DT.100031144  DT.101956375  DT.100031149 
    DT.121081997  DT.121453529  DT.121453549  DT.121453552  DT.91811927  DT.448397  DT.92441013  DT.95150500 

    24/417 AceView cDNA sequences (see all 417):

    BE885077 AA714846 CA488455 AI683736 AA357097 AI440387 BM785551 BE886245 
    AA605135 BE783177 AU125955 BE792697 AI280801 AW949411 BM761257 AA308252 
    AA485382 BP345370 CF141490 BI256815 BU729716 AA314609 BM664067 AW513714 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPL (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                                                        -                                                         
    SP2:                                                                                                                  
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:                                                        -                                                         


    ECgene alternative splicing isoforms for HNRNPL

    Expression
    for HNRNPL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNRNPL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACTCTTGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HNRNPL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSecondary SpermatocyteGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HNRNPL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNRNPL

    SOURCE GeneReport for Unigene cluster: Hs.644906
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    In Situ
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    Orthologs
    for HNRNPL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HNRNPL gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hnrnpl1 , 5 heterogeneous nuclear ribonucleoprotein L1, 5 91.3(n)1
    98.29(a)1    		   7 (16.93 cM)5
    153881  NM_177301.51  NP_796275.31 
     288085415 
    lizard
    (Anolis carolinensis)    		 Reptilia HNRNPL6
    		 --
    		 89(a)
    		 1 → many
    		 GL343665.1(40413-53340)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.13242 Xenopus laevis RNA-binding protein XlhnRNPL mRNA, partial more 79.19(n)    AF148690.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc554292 similar to heterogeneous nuclear ribonucleoprotein more 77.3(n)   394074  BC045336.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sm1 smooth 55.22(n)
    48.77(a)    		   37254  NM_001032268.2  NP_001027439.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea C44B7.21 Protein C44B7.2 48.52(n)
    42.62(a)    		   3565706  NM_063010.3  NP_495411.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PTB36
    		 polypyrimidine tract-binding protein 3
    		 29(a)
    		 1 → many
    		 1(16275108-16278624)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 polypyrimidine tract-binding protein, putative, ex...
    polypyrimidine tract-binding protein, putative, ex...
    		 29(a)
    28(a)
    		 many ↔ many
    many ↔ many
    		 5(21352461-21358180)
    1(37579409-37584185)


    ENSEMBL Gene Tree for HNRNPL (if available)
    TreeFam Gene Tree for HNRNPL (if available) 

    Paralogs
    for HNRNPL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HNRNPL gene
    PTBP12  PTBP32  HNRPLL2  PTBP22  
    1 SIMAP similar gene for HNRNPL using alignment to 5 protein entries:     HNRPL_HUMAN (see all proteins):
    HNRPLL

    HNRNPL for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HNRNPL
    PGOHUM00000258852 PGOHUM00000243056


    Genomic Variants
    for HNRNPL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/347 NCBI SNPs in HNRNPL are shown (see all 347)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs344619961,2
    		C--39326546(+) AAACCT/-TTTTT 2 -- ds50011Minor allele frequency- -:0.50NA 2
    rs1861160491,2
    		--39326560(+) TTGAGA/GTAGGG 2 -- ds50010--------
    rs72462781,2
    		C,F,A,--39326571(+) TCTCAC/TTGTCA 2 -- ds500111Minor allele frequency- T:0.06NA WA CSA EA 372
    rs1484729781,2
    		--39326628(+) AGGCTC/TAACTG 2 -- ds50010--------
    rs793321021,2
    		F,--39326695(+) CCTTTT/CTGTAG 2 -- ds50011Minor allele frequency- C:0.03WA 118
    rs23184591,2
    		C,F,A,H,--39326754(+) AGTATC/GTGCCC 2 -- ds500111Minor allele frequency- G:0.46NA WA CSA EA 373
    rs1901455311,2
    		--39326765(+) CACCTA/TGGCCT 2 -- ds50010--------
    rs23184601,2
    		C,F,A,H,--39326809(+) CACTGC/GGCCTG 2 -- ds500112Minor allele frequency- G:0.46NA WA CSA EA 376
    rs1425287201,2
    		--39326810(+) ACTGGA/GCCTGA 2 -- ds50010--------
    rs1475570281,2
    		--39326827(+) TTGCTC/TGGGCA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for HNRNPL (39327028 - 39342979 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HNRNPL
         1 CNV: 73366

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    Disorders / Diseases
    for HNRNPL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HNRNPL for disorders           About GeneDecksing

    OMIM gene information: 603083    OMIM disorders: --

    14 diseases for HNRNPL:    About MalaCards
    esophageal squamous cell carcinoma    squamous cell carcinoma    herpes simplex    fanconi's anemia
    down syndrome    anemia    esophagitis    pancreatic cancer
    osteosarcoma    pancreatitis    carcinoma    hypoxia
    hepatitis    malaria


    Export disorders for HNRNPL gene to outside databases

    Publications
    for HNRNPL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNRNPL gene, integrated from 9 sources (see all 94):
    (articles sorted by number of sources associating them with HNRNPL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts. (PubMed id 2687284)1, 2, 3 Pinol-Roma S.... Dreyfuss G. (1989)
    2. Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter. (PubMed id 11809897)1, 2, 9 Kuninger D.T....Mitra S. (2002)
    3. Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. (PubMed id 18669861)1, 2 Oberdoerffer S....Rao A. (2008)
    4. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Molecular basis of T cell-mediated recognition of pancreatic cancer cells. (PubMed id 11280764)1, 2 Ito M....Itoh K. (2001)
    7. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)
    8. Binding of hnRNP L to the pre-mRNA processing enhancer of the herpes simplex virus thymidine kinase gene enhances both polyadenylation and nucleocytoplasmic export of intronless mRNAs. (PubMed id 16024770)1, 9 Guang S....Mertz J.E. (2005)
    9. Heterogeneous nuclear ribonucleoprotein L Is a subuni t of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. (PubMed id 19332550)1, 9 Yuan W....Reinberg D. (2009)
    10. Heterogeneous nuclear ribonucleoprotein D/AUF1 interacts with heterogeneous nuclear ribonucleoprotein L. (PubMed id 18202450)1, 9 Park H.G....Choi M. (2007)

    External Searches for HNRNPL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HNRNPL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3191 HGNC: 5045 AceView: HNRPL Ensembl:ENSG00000104824 euGenes: HUgn3191
    ECgene: HNRNPL H-InvDB: HNRNPL

    Other Databases showing HNRNPL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HNRNPL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNRNPL Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HNRNPL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HNRNPL gene:
    Search GeneIP for patents involving HNRNPL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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