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Aliases for HNRNPL Gene

Aliases for HNRNPL Gene

  • Heterogeneous Nuclear Ribonucleoprotein L 2 3 5
  • HnRNP L 3 4
  • HNRPL 3 4
  • P/OKcl.14 3
  • HnRNP-L 3

External Ids for HNRNPL Gene

Previous HGNC Symbols for HNRNPL Gene

  • HNRPL

Previous GeneCards Identifiers for HNRNPL Gene

  • GC19M044022
  • GC19M039327
  • GC19M035773

Summaries for HNRNPL Gene

Entrez Gene Summary for HNRNPL Gene

  • Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPL Gene

HNRNPL (Heterogeneous Nuclear Ribonucleoprotein L) is a Protein Coding gene. Diseases associated with HNRNPL include Alzheimer Disease 19, Late Onset. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPLL.

UniProtKB/Swiss-Prot for HNRNPL Gene

  • Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897).

Gene Wiki entry for HNRNPL Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPL Gene

Genomics for HNRNPL Gene

Regulatory Elements for HNRNPL Gene

Enhancers for HNRNPL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G038673 2.1 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +157.5 157461 42.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF573 ZNF607 EID2B ACTN4 ENSG00000267152 RN7SL566P RPS16 LOC100631378 CAPN12 SUPT5H
GH19G038809 0.6 dbSUPER 4.9 +42.3 42314 0.8 BCOR ZNF579 ZNF121 ZMYM3 PRDM4 ZNF623 ZEB1 LGALS7 HNRNPL GC19P038813 GC19M038798 RNU6-140P
GH19G039073 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -221.6 -221597 1.8 ZNF493 SIN3A ZNF2 ZNF121 GLIS2 GATA2 FOS SP3 YY2 REST EID2B ENSG00000269069 MED29 ACP7 FBXO27 PAK4 RPS16 FBL ACTN4 EID2
GH19G038924 1.1 FANTOM5 ENCODE 1.4 -72.6 -72562 1.6 CTCF KLF17 ZMYM3 ZNF335 HIC1 GLIS2 ZFHX2 POLR2A PRDM10 EGR2 SARS2 ENSG00000267892 NFKBIB ZFP36 MAP4K1 HNRNPL MRPS12 CCER2
GH19G038846 1.5 ENCODE dbSUPER 0.7 +2.2 2159 6.6 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 FBL RPS16 ENSG00000267892 EID2B LGALS7 ENSG00000269688 RN7SL566P ZFP36 RINL ACTN4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HNRNPL on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109334 1647 4601 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548

Genomic Location for HNRNPL Gene

Chromosome:
19
Start:
38,836,378 bp from pter
End:
38,852,347 bp from pter
Size:
15,970 bases
Orientation:
Minus strand

Genomic View for HNRNPL Gene

Genes around HNRNPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPL Gene

Proteins for HNRNPL Gene

  • Protein details for HNRNPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14866-HNRPL_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein L
    Protein Accession:
    P14866
    Secondary Accessions:
    • A6ND69
    • A6NIT8
    • Q9H3P3

    Protein attributes for HNRNPL Gene

    Size:
    589 amino acids
    Molecular mass:
    64133 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with HNRNPLL (PubMed:18669861). Interacts with APEX1; the interaction is DNA-dependent (PubMed:11809897). Component of a complex with SETD2 (PubMed:19332550). Interacts with ELAVL1 (PubMed:18161049).
    Miscellaneous:
    • Excess hnRNP L activates NMD of its own mRNA by promoting the inclusion of a poison exon containing a premature stop codon and leading to nonsense-mediated decay. It also cross-regulates inclusion of an analogous poison exon in the hnRNP L-like pre-mRNA (PubMed:19124611).
    SequenceCaution:
    • Sequence=CAA34261.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPL Gene

    Alternative splice isoforms for HNRNPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPL Gene

Post-translational modifications for HNRNPL Gene

  • Phosphorylation at Ser-544 by CaMK4 enhances interaction with a CaMK4-responsive RNA element (CaRRE1), and prevents inclusion of the stress axis-regulated exon (STREX) of the KCNMA1 potassium channel transcripts upon membrane depolarization.
  • Several isoelectric forms of the L protein are probably the results of post-translational modifications.
  • Ubiquitination at isoforms=59, isoforms=97, isoforms=2229, posLast=248248, posLast=264264, posLast=277277, posLast=302302, isoforms=2455, posLast=493493, posLast=533533, and isoforms=2568
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPL Gene

Domains & Families for HNRNPL Gene

Gene Families for HNRNPL Gene

Graphical View of Domain Structure for InterPro Entry

P14866

UniProtKB/Swiss-Prot:

HNRPL_HUMAN :
  • RRM domain 2 has moderate RNA-binding affinity. RRM domains 3 and 4 may facilitate RNA looping when binding to two appropriately separated binding sites within the same target pre-mRNA (PubMed:23782695).
Domain:
  • RRM domain 2 has moderate RNA-binding affinity. RRM domains 3 and 4 may facilitate RNA looping when binding to two appropriately separated binding sites within the same target pre-mRNA (PubMed:23782695).
genes like me logo Genes that share domains with HNRNPL: view

Function for HNRNPL Gene

Molecular function for HNRNPL Gene

UniProtKB/Swiss-Prot Function:
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897).

Gene Ontology (GO) - Molecular Function for HNRNPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
GO:0003730 mRNA 3-UTR binding IEA --
GO:0005515 protein binding IPI 11809897
GO:0044212 transcription regulatory region DNA binding IDA 11809897
genes like me logo Genes that share ontologies with HNRNPL: view
genes like me logo Genes that share phenotypes with HNRNPL: view

Animal Models for HNRNPL Gene

MGI Knock Outs for HNRNPL:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HNRNPL Gene

Localization for HNRNPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPL Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules. {ECO:0000269 PubMed:17289661}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPL gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HNRNPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 15798186
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HNRNPL: view

Pathways & Interactions for HNRNPL Gene

genes like me logo Genes that share pathways with HNRNPL: view

Pathways by source for HNRNPL Gene

SIGNOR curated interactions for HNRNPL Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HNRNPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 25623890
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006396 RNA processing TAS 2687284
GO:0006397 mRNA processing IEA --
GO:0007623 circadian rhythm IEA --
genes like me logo Genes that share ontologies with HNRNPL: view

Drugs & Compounds for HNRNPL Gene

(1) Additional Compounds for HNRNPL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HNRNPL: view

Transcripts for HNRNPL Gene

Unigene Clusters for HNRNPL Gene

Heterogeneous nuclear ribonucleoprotein L:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPL Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for HNRNPL Gene

GeneLoc Exon Structure for
HNRNPL
ECgene alternative splicing isoforms for
HNRNPL

Expression for HNRNPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPL Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPL Gene



Protein tissue co-expression partners for HNRNPL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPL Gene:

HNRNPL

SOURCE GeneReport for Unigene cluster for HNRNPL Gene:

Hs.644906

Evidence on tissue expression from TISSUES for HNRNPL Gene

  • Nervous system(4.7)
  • Liver(4.6)
  • Skin(4.6)
  • Intestine(3.2)
  • Lung(3.2)
  • Kidney(3.1)
  • Muscle(3.1)
  • Heart(3)
  • Adrenal gland(2.8)
  • Bone marrow(2.8)
  • Gall bladder(2.8)
  • Lymph node(2.8)
  • Pancreas(2.8)
  • Spleen(2.8)
  • Stomach(2.8)
  • Thyroid gland(2.8)
  • Blood(2)
genes like me logo Genes that share expression patterns with HNRNPL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPL Gene

Orthologs for HNRNPL Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPL 34 35
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia HNRNPL 34 35
  • 94.84 (n)
dog
(Canis familiaris)
Mammalia HNRNPL 34 35
  • 94.51 (n)
rat
(Rattus norvegicus)
Mammalia Hnrnpl 34
  • 91.87 (n)
mouse
(Mus musculus)
Mammalia Hnrnpl 34 16 35
  • 91.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 98 (a)
ManyToMany
-- 35
  • 89 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpl 34
  • 77.71 (n)
Str.5918 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1324 34
zebrafish
(Danio rerio)
Actinopterygii hnrnpl2 35
  • 77 (a)
ManyToMany
hnrpl 34 35
  • 73.6 (n)
CABZ01100304.1 35
  • 52 (a)
ManyToMany
zgc55429 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8682 34
fruit fly
(Drosophila melanogaster)
Insecta sm 34 35
  • 54.13 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012054 34
  • 54 (n)
worm
(Caenorhabditis elegans)
Secernentea C44B7.2 34 35
  • 48.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2266 34
Species where no ortholog for HNRNPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPL Gene

ENSEMBL:
Gene Tree for HNRNPL (if available)
TreeFam:
Gene Tree for HNRNPL (if available)

Paralogs for HNRNPL Gene

Paralogs for HNRNPL Gene

(4) SIMAP similar genes for HNRNPL Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for HNRNPL Gene

genes like me logo Genes that share paralogs with HNRNPL: view

Variants for HNRNPL Gene

Sequence variations from dbSNP and Humsavar for HNRNPL Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000113012 -- 38,843,275(+) GGGAG(C/T)TGTCC intron-variant
rs1000219686 -- 38,851,631(+) TGGTG(A/G)CTCAC intron-variant, upstream-variant-2KB
rs1000355165 -- 38,851,918(+) ACGGG(A/G)GCGGG intron-variant, upstream-variant-2KB
rs1000417755 -- 38,851,795(+) GAGGG(A/G)ACAGG intron-variant, upstream-variant-2KB
rs1000523865 -- 38,843,775(+) AGGCC(C/T)ATTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPL Gene

Variant ID Type Subtype PubMed ID
esv29388 CNV loss 19812545
nsv1160616 CNV duplication 26073780

Variation tolerance for HNRNPL Gene

Residual Variation Intolerance Score: 6.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPL Gene

Disorders for HNRNPL Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNRNPL Gene - From: DISEASES

Disorder Aliases PubMed IDs
alzheimer disease 19, late onset
  • alzheimer's disease 19
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HNRNPL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPL
genes like me logo Genes that share disorders with HNRNPL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPL Gene

Publications for HNRNPL Gene

  1. Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. (PMID: 19332550) Yuan W. … Reinberg D. (J. Biol. Chem. 2009) 3 4 22 64
  2. Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter. (PMID: 11809897) Kuninger D.T. … Mitra S. (Nucleic Acids Res. 2002) 3 4 22 64
  3. A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts. (PMID: 2687284) Pinol-Roma S. … Dreyfuss G. (J. Cell Biol. 1989) 2 3 4 64
  4. hnRNP L inhibits CD44 V10 exon splicing through interacting with its upstream intron. (PMID: 25623890) Loh T.J. … Shen H. (Biochim. Biophys. Acta 2015) 3 4 64
  5. The Signature of the Five-Stranded vRRM Fold Defined by Functional, Structural and Computational Analysis of the hnRNP L Protein. (PMID: 26051023) Blatter M. … Allain F.H. (J. Mol. Biol. 2015) 3 4 64

Products for HNRNPL Gene

Sources for HNRNPL Gene

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