Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HNRNPK Gene

protein-coding GIFtS: 60
GCID: GC09M086582

heterogeneous nuclear ribonucleoprotein K

(Previous symbol: HNRPK)

Explore 33 diseases affiliated with
HNRNPK via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heterogeneous Nuclear Ribonucleoprotein K¹ ²		DC-Stretch Binding Protein²
HNRPK¹ ² ³ ⁵		Transformation Upregulated Nuclear Protein²
TUNP¹ ² ³		HnRNP K³
CSBP¹ ²		Transformation Up-Regulated Nuclear Protein³

External Ids:	HGNC: 5044¹	Entrez Gene: 3190²	Ensembl: ENSG00000165119⁷	OMIM: 600712⁵	UniProtKB: P61978³

Export aliases for HNRNPK gene to outside databases

Previous GC identifers: GC09M085775 GC09M056408

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HNRNPK:

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The

hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated

with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and

transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the

cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is

located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP

proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role

during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene,

however, not all of them are fully characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HNRPK_HUMAN, P61978

Function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in

the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind

poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both

transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a

role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned,

acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction

is necessary for the induction of apoptosis, but not cell cycle arrest

Gene Wiki entry for HNRNPK (HNRPK)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HNRNPK gene promoter:
Nkx3-1 Nkx6-1 Nkx3-1 v1 Nkx2-5 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HNRNPK promoter sequence

Search SABiosciences Chromatin IP Primers for HNRNPK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.32-q21.33 Ensembl cytogenetic band: 9q21.32 HGNC cytogenetic band: 9q21.32-q21.33

HNRNPK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPK gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M086582: view genomic region (about GC identifiers)

Start:	86,582,998 bp from pter	End:	86,595,569 bp from pter
Size:	12,572 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HNRPK_HUMAN, P61978 (See protein sequence)

Recommended Name: Heterogeneous nuclear ribonucleoprotein K

Size: 463 amino acids; 50976 Da

Subunit: Interacts with RBM42 and ZIK1. Interacts with BRDT (By similarity). Identified in the spliceosome C complex.

Interacts with ANKRD28. Interacts with HCV core protein. Interacts with ASFV p30 protein. Interacts with DDX1.

Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation. Interacts with p53/TP53

Subcellular location: Cytoplasm. Nucleus, nucleoplasm. Note=Recruited to p53/TP53-responsive promoters, in the presence

of functional p53/TP53. In case of ASFV infection, there is a shift in the localization which becomes predominantly

nuclear

Mass spectrometry: Mass=50976.25; Method=MALDI; Range=1-463 (P61978-1); Source=PubMed:11840567;

Sequence caution: Sequence=BAD92799.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

5 PDB 3D structures from and Proteopedia for HNRNPK:

1J5K (3D)

1KHM (3D)

1ZZI (3D)

1ZZJ (3D)

1ZZK (3D)

Secondary accessions: Q07244 Q15671 Q59F98 Q5T6W4 Q60577 Q922Y7 Q96J62

Alternative splicing: 3 isoforms: P61978-1, Q07244-1 P61978-2, Q07244-2 P61978-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HNRNPK: NX_P61978

Post-translational modifications:

Arg-296 and Arg-299 are dimethylated, probably to asymmetric dimethylarginine¹

Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light

and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions¹

Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK

poly-ubiquitination¹

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P61978

HNRNPK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_002131.2 NP_112552.1 NP_112553.1

ENSEMBL proteins:

ENSP00000365458 ENSP00000365444 ENSP00000317788 ENSP00000397725 ENSP00000353552

ENSP00000409456 ENSP00000365432 ENSP00000365440 ENSP00000365439

Reactome Protein details: P61978
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 3): HNRNPK OriGene Protein Over-expression Lysate (see all 4): HNRNPK OriGene Custom Protein Services for HNRNPK
	GenScript Custom Purified and Recombinant Proteins Services for HNRNPK
	Novus Biologicals HNRNPK Protein Novus Biologicals HNRNPK Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HNRNPK

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	IDA	--
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--

HNRNPK for ontologies About GeneDecksing

HNRNPK Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HNRNPK
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for HNRNPK (hnRNP K)
	OriGene Antibodies (see all 2): HNRNPK OriGene Custom Antibody Services for HNRNPK
	GenScript Custom Superior Antibodies Services for HNRNPK
	Novus Biologicals HNRNPK Antibodies
	Abcam antibodies for HNRNPK
	Uscn Antibodies for HNRNPK
	ThermoFisher Antibody for HNRNPK

Assay Products for HNRNPK:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HNRNPK
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HNRNPK

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HNRNPK for domains About GeneDecksing

3 InterPro domains/families:

IPR004087 KH_dom

IPR012987 ROK_N

IPR004088 KH_dom_type_1

Graphical View of Domain Structure for InterPro Entry P61978

ProtoNet protein and cluster: P61978

2 Blocks protein families:

IPB004087 KH domain

IPB012987 ROK

UniProtKB/Swiss-Prot: HNRPK_HUMAN, P61978

Similarity: Contains 3 KH domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HNRPK_HUMAN, P61978

Function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in

the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind

poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both

transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a

role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned,

acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction

is necessary for the induction of apoptosis, but not cell cycle arrest

Induction: By DNA damage, including ionizing radiations and phleomycin treatment or UV irradiation. This induction

requires ATM kinase activity (ionizing radiations and phleomycin) or ATR activity (UV irradiation). Up-regulation is

due to protein stabilization. Constitutive protein levels are controlled by MDM2-mediated ubiquitination and

degradation via the proteasome pathway

miRNA Products:		miRTarBase miRNAs that target HNRNPK: hsa-mir-21 (MIRT005325), hsa-mir-450a (MIRT004345)

		OriGene 3'-UTR Clone (see all 3): HNRNPK Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HNRNPK
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRNPK (see all 27):
		hsa-miR-124* hsa-miR-3685 hsa-miR-323-3p hsa-miR-520d-5p hsa-miR-539 hsa-miR-4299 hsa-miR-105 hsa-miR-3916

		SwitchGear 3'UTR luciferase reporter plasmid: HNRNPK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HNRNPK (see all 4) OriGene shRNA RFP: HNRNPK OriGene siRNA: HNRNPK
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HNRNPK

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HNRNPK

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPK (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPK (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): HNRNPK (NM_031263)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPK
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPK

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HNRNPK
		Search LifeMap BioReagents cell lines for HNRNPK

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPK

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	IMP	--
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IMP	--
GO:0003697	single-stranded DNA binding	TAS	--
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	19174163

HNRNPK for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for HNRNPK:

Cell division defect	Decreased homologous recombina	Increased G2M DNA content	Increased cell death in breast
Increased gamma-H2AX phosphory	Increased number of mitotic ce

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing - Major Pathway	1.00	mRNA Processing	0.82
mRNA Splicing	1.00	mRNA processing	0.48
Processing of Capped Intron-Containing Pre-mRNA	0.96	Spliceosome	0.31

B Cell Receptor Signaling Pathway

B Cell Receptor Signaling Pathway

1.00

Translational Control

Translational Control

1.00

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for HNRNPK

Translational Control

2 BioSystems Pathways for HNRNPK

	mRNA processing
	B Cell Receptor Signaling Pathway

5 Reactome Pathways for HNRNPK

	mRNA Splicing - Major Pathway
	mRNA Splicing
	Gene Expression
	mRNA Processing
	Processing of Capped Intron-Containing Pre-mRNA

1 Kegg Pathway (Kegg details for HNRNPK):

Spliceosome

HNRNPK for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HNRNPK

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/1055 Interacting proteins for HNRNPK (P61978^{1, 2, 3} ENSP00000365439⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 1055)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3A	P68431³	I2D: score=1
HIST1H3B	P68431³	I2D: score=1
HIST1H3C	P68431³	I2D: score=1
HIST1H3D	P68431³	I2D: score=1
HIST1H3E	P68431³	I2D: score=1

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0006396	RNA processing	TAS	8107114
GO:0007165	signal transduction	TAS	16130169
GO:0008380	RNA splicing	TAS	--
GO:0010467	gene expression	TAS	--

HNRNPK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HNRNPK for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HNRNPK
3 Novoseek chemical compound relationships for HNRNPK gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
poly c	65.8	2	1729596 (1)
tyrosine	35.8	7	15860232 (2), 16854432 (2)
cytosine	18.7	2	15361071 (1), 11278705 (1)

Search CenterWatch for drugs/clinical trials and news about HNRNPK / HNRPK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HNRNPK gene (3 alternative transcripts):

NM_002140.3 NM_031262.2 NM_031263.2

Unigene Cluster for HNRNPK:

Heterogeneous nuclear ribonucleoprotein K

Hs.522257 [show with all ESTs]

Unigene Representative Sequence: NM_002140

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376281(uc011lsw.2 uc004and.4 uc004anl.4) ENST00000376268

ENST00000351839 ENST00000435158 ENST00000360384 ENST00000493362 ENST00000492865

ENST00000481820 ENST00000457156 ENST00000376256 ENST00000472778 ENST00000483135

ENST00000376264(uc004anm.4) ENST00000376263(uc004anf.4 uc004ang.4 uc004anh.4 uc011lsx.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): HNRNPK Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HNRNPK
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRNPK (see all 27):
		hsa-miR-124* hsa-miR-3685 hsa-miR-323-3p hsa-miR-520d-5p hsa-miR-539 hsa-miR-4299 hsa-miR-105 hsa-miR-3916

		SwitchGear 3'UTR luciferase reporter plasmid: HNRNPK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HNRNPK (see all 4) OriGene shRNA RFP: HNRNPK OriGene siRNA: HNRNPK
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HNRNPK

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPK (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPK (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): HNRNPK (NM_031263)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPK
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPK

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HNRNPK Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HNRNPK
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HNRNPK
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRNPK

Additional cDNA sequence:

AB209562.1 AB451263.1 AB451390.1 AK096385.1 AK123117.1 AK291336.1 AK294067.1 AK300744.1

AK307962.1 AY911506.1 BC000355.2 BC013220.1 BC014980.1 BC025321.1 CR456771.1 S74678.1

X72727.1

24/79 DOTS entries (see all 79):

DT.95203404 DT.99997266 DT.92471004 DT.100045527 DT.100691601 DT.40210631 DT.100847871 DT.100691597

DT.121167909 DT.121167999 DT.95275135 DT.101976217 DT.95275150 DT.95337834 DT.100855178 DT.100691576

DT.95143559 DT.100691604 DT.92387024 DT.92471018 DT.100691577 DT.100691600 DT.100876532 DT.95275255

24/96 AceView cDNA sequences (see all 96):

CK819110 AA031892 BM677048 BM685985 BM128061 T89204 AL560321 AW239147

CB409932 H13039 AA452668 R81030 AA399206 BE300406 BM663632 W93157

BE313952 AA226170 W73806 BM127994 BM127791 BF690066 CK819111 AA258207

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPK (see all 9) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18
SP1:			-
SP2:
SP3:
SP4:											-		-		-		-		-		-		-		-		-		-		-
SP5:																							-

ECgene alternative splicing isoforms for HNRNPK

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HNRNPK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCCTGGCAT

About this image
See HNRNPK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HNRNPK

SOURCE GeneReport for Unigene cluster: Hs.522257

SABiosciences Custom PCR Arrays for HNRNPK

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HNRNPK Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HNRNPK
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HNRNPK
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRNPK

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HNRNPK gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HNRNPK¹	heterogeneous nuclear ribonucleoprotein K-like	83.33(n) 95.58(a)		427458 XM_425032.3 XP_425032.2
lizard (Anolis carolinensis)	Reptilia	HNRNPK⁶	--	90(a)	1 ↔ 1	2(42561266-42575155)
African clawed frog (Xenopus laevis)	Amphibia	hnrpk-prov²	heterogeneous nuclear ribonucleoprotein K	83.44(n)		BC044711.1
zebrafish (Danio rerio)	Actinopterygii	Dr.24225²	Danio rerio mRNA similar to heterogeneous nuclear ribonucleoprotein more	78.77(n)		BC047844.1
fruit fly (Drosophila melanogaster)	Insecta	bl⁶	bancal	27(a)	1 ↔ 1	2R(16475010-16494359)
worm (Caenorhabditis elegans)	Secernentea	F26B1.2¹	Protein F26B1.2	51.99(n) 49.24(a)		172330 NM_170880.3 NP_740869.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G25970⁶ AT4G10070⁶ (see all 3)	KH domain-containing protein (see all 3)	6(a) 5(a) (see all 3)	possible ortholog possible ortholog (see all 3)	2(11071651-11075669) 4(6295608-6299836)
rice (Oryza sativa)	Liliopsida	-- --	KH domain-containing protein, putative, expressed	6(a) 5(a)	possible ortholog possible ortholog	2(6979511-6985051) 8(571856-577417)

ENSEMBL Gene Tree for HNRNPK (if available)
TreeFam Gene Tree for HNRNPK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HNRNPK gene

FUBP1² PCBP4² KHSRP² PCBP3² PCBP2² NOVA2² PCBP1² NOVA1²

FUBP3²

2 SIMAP similar genes for HNRNPK using alignment to 4 protein entries: HNRPK_HUMAN (see all proteins):

HNRPK PCBP2

HNRNPK for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for HNRNPK
PGOHUM00000242216 PGOHUM00000240356 PGOHUM00000238098 PGOHUM00000235129 PGOHUM00000235390

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75556662^1,2	F,	--	56408307(+)	`CAAAAA/CCAGTT`	3	--	ds500¹		1		NA	120
rs11140311^1,2		--	56408665(+)	`AGGAAC/TGTTTC`	3	--	ut3¹ ese³		1		NA	120
rs11548852^1,2	C	--	56409201(+)	`AAAAAC/AAAACA`	3	--	ut3¹		1		NA	2
rs1055950^1,2	C	--	56409615(-)	`TGAACA/CCCTTG`	3	--	ut3¹		2		NA	4
rs7033844^1,2	C,	--	56409659(+)	`CAACAA/GTAACG`	3	--	ut3¹		0	--	--	--	--
rs14961^1,2	F,	--	56409664(-)	`TTTTTT/CGTTAT`	3	--	ut3¹		3		MN	556
rs11548848^1,2	C	--	56409793(-)	`GGTGTA/GGTGAA`	3	--	ut3¹		2		NA	4
rs112635088^1,2	F	--	56410994(+)	`ATGATG/CTAACG`	3	--	int¹		3		CSA	10
rs78280596^1,2	F,	--	56411155(+)	`TCACTA/GAAGCC`	3	--	int¹		1		WA	118
rs77120505^1,2	C,F,	--	56412158(+)	`AAAACG/ATGAAC`	3	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for HNRNPK (86582998 - 86595569 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for HNRNPK
2 CNVs: 31520 3773
1 Inversion: 29497

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HNRNPK

DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPK

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HNRNPK for disorders           About GeneDecksing

OMIM gene information: 600712    OMIM disorders: --

20/33 diseases for HNRNPK (see all 33):    About MalaCards

wiskott-aldrich syndrome fragile x syndrome oral squamous cell carcinoma oral leukoplakia

leukoplakia squamous cell carcinoma aplastic anemia chronic myeloid leukemia

herpes simplex myeloid leukemia kaposi's sarcoma gallbladder carcinoma

hepatitis c colorectal cancer hepatitis b prostate cancer

anemia sarcoma nasopharyngitis carcinoma

7 Novoseek disease relationships for HNRNPK gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colorectal cancer	16.4	1	16953238 (1)
mental retardation	4.26	2	9178771 (1), 8156595 (1)
carcinoma squamous cell	0	2	17667924 (1), 17667925 (1)
shock	0	2	15668997 (1), 15682461 (1)
tumors	0	2	19609950 (1), 17612614 (1)
prostate cancer	0	2	19401687 (2)
cancer	0	2	19609950 (1), 17612614 (1)

Human Genome Epidemiology (HuGE) Navigator: HNRNPK (1 document)

Export disorders for HNRNPK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HNRNPK gene, integrated from 9 sources (see all 235):
(articles sorted by number of sources associating them with HNRNPK)

Utopia: connect your pdf to the dynamic
world of online information

Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing. (PubMed id 8107114)^{1, 2, 3} Dejgaard K.... Celis J.E. (1994)
hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. (PubMed id 16360036)^{1, 2, 9} Moumen A....Jackson S.P. (2005)
Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K. (PubMed id 9651361)^{1, 2, 9} Hsieh T.-Y.... Lai M.M.C. (1998)
PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K. (PubMed id 16564677)^{1, 2, 9} Kwiek N.C.... Haystead T.A.J. (2006)
Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein. (PubMed id 1729596)^{1, 2, 9} Matunis M.J.... Dreyfuss G. (1992)
DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation. (PubMed id 22825850)^{1, 2} Pelisch F.... Srebrow A. (2012)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Molecular basis of sequence-specific single-stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single-stranded DNA. (PubMed id 12093748)^{1, 2} Braddock D.T.... Clore G.M. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3190	HGNC: 5044	AceView: HNRPK.1	Ensembl:ENSG00000165119	euGenes: HUgn3190
ECgene: HNRNPK	Kegg: 3190	H-InvDB: HNRNPK

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HNRNPK	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HNRNPK gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HNRNPK gene:
Search GeneIP for patents involving HNRNPK

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of HNRNPK
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for HNRNPK		OriGene shRNA RFP for HNRNPK
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HNRNPK		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HNRNPK
	OriGene Protein Over-expression Lysate for HNRNPK		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HNRNPK		OriGene 3'-UTR Clone for HNRNPK
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPK		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPK
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for HNRNPK		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HNRNPK		OriGene Custom Protein Services for HNRNPK
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HNRNPK
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HNRNPK
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPK
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HNRNPK
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRNPK
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HNRNPK

	GenScript Custom Purified and Recombinant Proteins Services for HNRNPK		GenScript cDNA clones with any tag delivered in your preferred vector for HNRNPK
	GenScript Custom Assay Services for HNRNPK		GenScript Custom Superior Antibodies Services for HNRNPK
	GenScript Custom overexpressing Cell Line Services for HNRNPK		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for HNRNPK
(hnRNP K)

	Regulatory tfbs in HNRNPK promoter
	Search Chromatin IP Primers for HNRNPK
	RT² qPCR Primer Assay in human, mouse, rat HNRNPK
	GNC Network for HNRNPK
	SABiosciences Custom PCR Arrays for HNRNPK

Search Tocris compounds for HNRNPK

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HNRNPK antibodies
	HNRNPK proteins
	HNRNPK lysates

	Antibodies for HNRNPK
	See all of Abcam's Antibodies, Kits and Proteins for HNRNPK
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

HNRNPK Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HNRNPK

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPK

	SwitchGear 3'UTR luciferase reporter plasmids for HNRNPK
	SwitchGear Promoter luciferase reporter plasmids for HNRNPK

ThermoFisher Antibody for HNRNPK

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPK

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HNRNPK gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

HNRNPK Gene

heterogeneous nuclear ribonucleoprotein K

Aliases
for HNRNPK gene

Summaries
for HNRNPK gene

Genomic Views
for HNRNPK gene

Proteins
for HNRNPK gene

Protein Domains /
Families
for HNRNPK gene

Function
for HNRNPK gene

Pathways & Interactions
for HNRNPK gene

Drugs & Compounds
for HNRNPK gene

Transcripts
for HNRNPK gene

Expression
for HNRNPK gene

Orthologs
for HNRNPK gene

Paralogs
for HNRNPK gene

Genomic Variants
for HNRNPK gene

Disorders / Diseases
for HNRNPK gene

Publications
for HNRNPK gene

External Searches for HNRNPK gene

Genome Databases showing HNRNPK gene

Other Databases showing HNRNPK gene

Specialized Databases showing HNRNPK gene

Intellectual Property
for HNRNPK gene

Products
for HNRNPK gene

View Random Gene

Advanced Search

Export list of displayed genes

HNRNPK Gene

heterogeneous nuclear ribonucleoprotein K

Aliasesfor HNRNPK gene

Summariesfor HNRNPK gene

Genomic Viewsfor HNRNPK gene

Proteinsfor HNRNPK gene

Protein Domains /Familiesfor HNRNPK gene

Functionfor HNRNPK gene

Pathways & Interactionsfor HNRNPK gene

Drugs & Compoundsfor HNRNPK gene

Transcriptsfor HNRNPK gene

Expression for HNRNPK gene

Orthologsfor HNRNPK gene

Paralogsfor HNRNPK gene

Genomic Variantsfor HNRNPK gene

Disorders / Diseasesfor HNRNPK gene

Publicationsfor HNRNPK gene

External Searches for HNRNPK gene

Genome Databases showing HNRNPK gene

Other Databases showing HNRNPK gene

Specialized Databases showing HNRNPK gene

Intellectual Propertyfor HNRNPK gene

Productsfor HNRNPK gene

View Random Gene

Aliases
for HNRNPK gene

Summaries
for HNRNPK gene

Genomic Views
for HNRNPK gene

Proteins
for HNRNPK gene

Protein Domains /
Families
for HNRNPK gene

Function
for HNRNPK gene

Pathways & Interactions
for HNRNPK gene

Drugs & Compounds
for HNRNPK gene

Transcripts
for HNRNPK gene

Expression
for HNRNPK gene

Orthologs
for HNRNPK gene

Paralogs
for HNRNPK gene

Genomic Variants
for HNRNPK gene

Disorders / Diseases
for HNRNPK gene

Publications
for HNRNPK gene

Intellectual Property
for HNRNPK gene

Products
for HNRNPK gene