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HNRNPK Gene

protein-coding   GIFtS: 60
GCID: GC09M086582

Heterogeneous Nuclear Ribonucleoprotein K


(Previous symbol: HNRPK)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein K1 2     CSBP2
HNRPK1 2 3 5     DC-Stretch Binding Protein2
Transformation Upregulated Nuclear Protein1 2     HnRNP K3
TUNP2 3     Transformation Up-Regulated Nuclear Protein3

External Ids:    HGNC: 50441   Entrez Gene: 31902   Ensembl: ENSG000001651197   OMIM: 6007125   UniProtKB: P619783   

Export aliases for HNRNPK gene to outside databases

Previous GC identifers: GC09M085775 GC09M056408


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPK Gene:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are
associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA
metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the
nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded
by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct
among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also
thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been
described for this gene, however, not all of them are fully characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for HNRNPK Gene:
HNRNPK (heterogeneous nuclear ribonucleoprotein K) is a protein-coding gene. GO annotations related to this gene include single-stranded DNA binding and RNA binding. An important paralog of this gene is PCBP2.

UniProtKB/Swiss-Prot: HNRPK_HUMAN, P61978
Function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a
role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can
also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the
level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of
p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription
repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced
by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest

Gene Wiki entry for HNRNPK (HNRPK) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPK gene promoter:
         Nkx3-1   Nkx6-1   Nkx3-1 v1   Nkx2-5   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HNRNPK promoter sequence
   Search Chromatin IP Primers for HNRNPK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.32-q21.33   Ensembl cytogenetic band:  9q21.32   HGNC cytogenetic band: 9q21.32-q21.33

HNRNPK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPK gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M086582:  view genomic region     (about GC identifiers)

Start:
86,582,998 bp from pter      End:
86,595,569 bp from pter
Size:
12,572 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HNRPK_HUMAN, P61978 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein K  
Size: 463 amino acids; 50976 Da
Subunit: Interacts with RBM42 and ZIK1. Interacts with BRDT (By similarity). Identified in the spliceosome C
complex. Interacts with ANKRD28. Interacts with HCV core protein. Interacts with ASFV p30 protein. Interacts with
DDX1. Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation. Interacts with
p53/TP53
Mass spectrometry: Mass=50976.25; Method=MALDI; Range=1-463 (P61978-1); Source=PubMed:11840567;
Sequence caution: Sequence=BAD92799.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
5 PDB 3D structures from and Proteopedia for HNRNPK:
1J5K (3D)        1KHM (3D)        1ZZI (3D)        1ZZJ (3D)        1ZZK (3D)    
Secondary accessions: Q07244 Q15671 Q59F98 Q5T6W4 Q60577 Q922Y7 Q96J62
Alternative splicing: 3 isoforms:  P61978-1, Q07244-1   P61978-2, Q07244-2   P61978-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HNRNPK: NX_P61978

Explore proteomics data for HNRNPK at MOPED

Post-translational modifications: 

  • Arg-296 and Arg-299 are dimethylated, probably to asymmetric dimethylarginine1
  • Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV
    light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions1
  • Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK
    poly-ubiquitination1
  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner1
  • Ubiquitination2 at Lys34, Lys52, Lys163, Lys179, Lys198, Lys219, Lys405, Lys422, Lys456, Lys461
  • Modification sites at PhosphoSitePlus

  • See HNRNPK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_002131.2  NP_112552.1  NP_112553.1  

    ENSEMBL proteins: 
     ENSP00000365458   ENSP00000317788   ENSP00000353552   ENSP00000473957   ENSP00000409456  
     ENSP00000475098   ENSP00000365440   ENSP00000365439  
    Reactome Protein details: P61978

    HNRNPK Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for HNRNPK
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for HNRNPK (9 products) 

     
    antibodies-online peptides for HNRNPK

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004087 KH_dom
     IPR012987 ROK_N
     IPR004088 KH_dom_type_1

    Graphical View of Domain Structure for InterPro Entry P61978

    ProtoNet protein and cluster: P61978

    2 Blocks protein domains:
    IPB004087 KH domain
    IPB012987 ROK


    UniProtKB/Swiss-Prot: HNRPK_HUMAN, P61978
    Similarity: Contains 3 KH domains


    Find genes that share domains with HNRNPK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRPK_HUMAN, P61978
    Function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a
    role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can
    also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the
    level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of
    p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription
    repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced
    by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest
    Induction: By DNA damage, including ionizing radiations and phleomycin treatment or UV irradiation. This induction
    requires ATM kinase activity (ionizing radiations and phleomycin) or ATR activity (UV irradiation). Up-regulation
    is due to protein stabilization. Constitutive protein levels are controlled by MDM2-mediated ubiquitination and
    degradation via the proteasome pathway

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP--
    GO:0003697single-stranded DNA binding TAS--
    GO:0003723RNA binding TAS8107114
    GO:0005515protein binding IPI12183465
         
    Find genes that share ontologies with HNRNPK           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for HNRNPK:
     Cell division defect  Decreased homologous recombina  Increased G2M DNA content  Increased cell death in breast 
     Increased gamma-H2AX phosphory  Increased number of mitotic ce 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HNRNPK

    miRNA
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    miRTarBase miRNAs that target HNRNPK:
    hsa-mir-15b-5p (MIRT046389), hsa-mir-1260b (MIRT052770), hsa-mir-877-3p (MIRT037186), hsa-mir-503-5p (MIRT041102), hsa-mir-450a-5p (MIRT004345), hsa-mir-21-5p (MIRT005325), hsa-mir-615-3p (MIRT040216), hsa-mir-30c-5p (MIRT047832), hsa-mir-125b-5p (MIRT045940), hsa-mir-106b-3p (MIRT038583), hsa-mir-484 (MIRT042152), hsa-mir-328-3p (MIRT043787), hsa-mir-23b-3p (MIRT046352)

    Block miRNA regulation of human, mouse, rat HNRNPK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPK (see all 27):
    hsa-miR-124* hsa-miR-3685 hsa-miR-323-3p hsa-miR-520d-5p hsa-miR-539 hsa-miR-4299 hsa-miR-105 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPK 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HNRPK_HUMAN, P61978: Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to
    p53/TP53-responsive promoters, in the presence of functional p53/TP53. In case of ASFV infection, there is a
    shift in the localization which becomes predominantly nuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA--
    GO:0002102podosome IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with HNRNPK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPK About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Influenza A
    Herpes simplex infection0.33
    4Viral carcinogenesis
    Viral carcinogenesis
    5Translational Control
    Translational Control


    Find genes that share SuperPaths with HNRNPK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HNRNPK
        EphB-EphrinB Signaling

    1 Cell Signaling Technology (CST) Pathway for HNRNPK
        Translational Control

    2 BioSystems Pathways for HNRNPK
        mRNA processing
    B Cell Receptor Signaling Pathway


    2 Reactome Pathways for HNRNPK
        mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA


    4 Kegg Pathways  (Kegg details for HNRNPK):
        Spliceosome
    Herpes simplex infection
    Viral carcinogenesis
    MicroRNAs in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPK
    Interactions:

        GeneGlobe Interaction Network for HNRNPK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPK (P619781, 2, 3 ENSP000003654394) via UniProtKB, MINT, STRING, and/or I2D (see all 1114)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006396RNA processing TAS8107114
    GO:0007165signal transduction TAS16130169
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with HNRNPK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPK (HNRPK)

    3 Novoseek inferred chemical compound relationships for HNRNPK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly c 65.8 2 1729596 (1)
    tyrosine 35.8 7 15860232 (2), 16854432 (2)
    cytosine 18.7 2 15361071 (1), 11278705 (1)



    Find genes that share compounds with HNRNPK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HNRNPK gene (3 alternative transcripts): 
    NM_002140.3  NM_031262.2  NM_031263.2  

    Unigene Cluster for HNRNPK:

    Heterogeneous nuclear ribonucleoprotein K
    Hs.522257  [show with all ESTs]
    Unigene Representative Sequence: NM_002140
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376281(uc011lsw.2 uc004and.4 uc004anl.4) ENST00000351839
    ENST00000360384 ENST00000493362 ENST00000492865 ENST00000481820 ENST00000457156
    ENST00000472778 ENST00000376256 ENST00000483135 ENST00000376264(uc004anm.4)
    ENST00000376263(uc004anf.4 uc004ang.4 uc004anh.4 uc011lsx.2)

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    Additional mRNA sequence: 

    AB209562.1 AB451263.1 AB451390.1 AK096385.1 AK123117.1 AK291336.1 AK294067.1 AK300744.1 
    AK307962.1 AY911506.1 BC000355.2 BC013220.1 BC014980.1 BC025321.1 CR456771.1 S74678.1 
    X72727.1 

    Selected DOTS entries (see all 79):

    DT.95203404  DT.99997266  DT.92471004  DT.100045527  DT.100691601  DT.40210631  DT.100847871  DT.100691597 
    DT.121167909  DT.121167999  DT.95275135  DT.101976217  DT.95275150  DT.95337834  DT.100855178  DT.100691576 
    DT.95143559  DT.100691604  DT.92387024  DT.92471018  DT.100691577  DT.100691600  DT.100876532  DT.95275255 

    Selected AceView cDNA sequences (see all 96):

    AA031892 BM128061 T89204 CK819110 BM677048 BM685985 AL560321 H13039 
    R81030 AW239147 AA452668 AA399206 CB409932 W73806 BM127994 BE300406 
    BM127791 CK819111 BF690066 BE313952 AA226170 W93157 BM663632 W60856 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPK (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18
    SP1:        -                                                                                                                                       
    SP2:                                                                                                                                                
    SP3:                                                                                                                                                
    SP4:                                -     -     -     -     -     -     -     -     -     -     -                                                   
    SP5:                                                                    -                                                                           


    ECgene alternative splicing isoforms for HNRNPK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTGGCAT
    HNRNPK Expression
    About this image


    HNRNPK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    HNRNPK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522257
        Custom PCR Arrays for HNRNPK
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HNRNPK gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpk1 , 5 heterogeneous nuclear ribonucleoprotein K1, 5 93.75(n)1
    99.78(a)1
      13 (31.04 cM)5
    153871  NM_025279.21  NP_079555.11 
     583911425 
    chicken
    (Gallus gallus)
    Aves HNRPK6
    heterogeneous nuclear ribonucleoprotein K
    96(a)
    1 → many
    JH376210.1(13811-34765)
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPK6
    heterogeneous nuclear ribonucleoprotein K
    90(a)
    1 ↔ 1
    2(42561266-42575155)
    African clawed frog
    (Xenopus laevis)
    Amphibia hnrpk-prov2 heterogeneous nuclear ribonucleoprotein K 83.44(n)    BC044711.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.242252 Danio rerio mRNA similar to heterogeneous nuclear ribonucleoprotein more 78.77(n)    BC047844.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bl6
    bancal
    34(a)
    1 ↔ 1
    2R(16475010-16494359)
    worm
    (Caenorhabditis elegans)
    Secernentea F26B1.26
    Protein F26B1.2, isoform a
    43(a)
    1 ↔ 1
    I(6317701-6320419) WBGene00017816
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PBP26
    RNA binding protein with similarity to mammalian h...
    23(a)
    1 → many
    II(683428-684669) YBR233W


    ENSEMBL Gene Tree for HNRNPK (if available)
    TreeFam Gene Tree for HNRNPK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPK gene
    PCBP22  NOVA22  PCBP42  ENSG000002727622  PCBP12  NOVA12  PCBP32  
    3 SIMAP similar genes for HNRNPK using alignment to 6 protein entries:     HNRPK_HUMAN (see all proteins):
    HNRPK    PCBP3    PCBP2

    Find genes that share paralogs with HNRNPK           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for HNRNPK
    PGOHUM00000242216 PGOHUM00000240356 PGOHUM00000238098 PGOHUM00000235129 PGOHUM00000235390


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPK (see all 356)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018635191,2
    C--56414906(-) AATTTG/TTTTTT 3 -- int10--------
    rs1481914251,2
    --86462016(+) TAAATG/TCAATA 3 -- ds50010--------
    rs1839689341,2
    --86462069(+) TTGAGA/GCAGGA 3 -- ds50010--------
    rs1412299021,2
    --86462079(+) AAGATC/TGCTTG 3 -- ds50010--------
    rs1869639621,2
    --86462086(+) CTTGTA/GCCCAG 3 -- ds50010--------
    rs1904576501,2
    --86462159(+) GACACC/TGTCTC 3 -- ds50010--------
    rs755566621,2
    F--86462191(+) CAAAAA/CCAGTT 3 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1827380351,2
    --86462202(+) TTCAAC/GCTTTC 3 -- ds50010--------
    rs1507394131,2
    --86462251(+) TGAGCC/TGGGAA 3 -- ds50010--------
    rs1381466571,2
    --86462384(+) CTGACA/TATAAG 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for HNRNPK (86582998 - 86595569 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for HNRNPK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831644CNV Gain17160897
    nsv893514CNV Gain21882294
    nsv8541CNV Gain18304495
    dgv2394e1CNV Complex17122850
    nsv469859CNV Complex16826518
    nsv436717OTHER Inversion17901297

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600712    OMIM disorders: --


    Find genes that share disorders with HNRNPK           About GenesLikeMe

    7 Novoseek inferred disease relationships for HNRNPK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 16.4 1 16953238 (1)
    mental retardation 4.26 2 9178771 (1), 8156595 (1)
    carcinoma squamous cell 0 2 17667924 (1), 17667925 (1)
    shock 0 2 15668997 (1), 15682461 (1)
    tumors 0 2 19609950 (1), 17612614 (1)
    prostate cancer 0 2 19401687 (2)
    cancer 0 2 19609950 (1), 17612614 (1)

    Human Genome Epidemiology (HuGE) Navigator: HNRNPK (1 document)

    Export disorders for HNRNPK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPK gene, integrated from 10 sources (see all 269):
    (articles sorted by number of sources associating them with HNRNPK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing. (PubMed id 8107114)1, 2, 3 Dejgaard K.... Celis J.E. (J. Mol. Biol. 1994)
    2. hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. (PubMed id 16360036)1, 2, 9 Moumen A.... Jackson S.P. (Cell 2005)
    3. Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K. (PubMed id 9651361)1, 2, 9 Hsieh T.-Y.... Lai M.M.C. (J. Biol. Chem. 1998)
    4. PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K. (PubMed id 16564677)1, 2, 9 Kwiek N.C.... Haystead T.A.J. (Cell. Signal. 2006)
    5. Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein. (PubMed id 1729596)1, 2, 9 Matunis M.J.... Dreyfuss G. (Mol. Cell. Biol. 1992)
    6. DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation. (PubMed id 22825850)1, 2 Pelisch F.... Srebrow A. (J. Biol. Chem. 2012)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3190 HGNC: 5044 AceView: HNRPK.1 Ensembl:ENSG00000165119 euGenes: HUgn3190
    ECgene: HNRNPK Kegg: 3190 H-InvDB: HNRNPK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HNRNPK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HNRNPK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPK gene:
    Search GeneIP for patents involving HNRNPK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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