Aliases for HNRNPK Gene
Aliases for HNRNPK Gene
External Ids for HNRNPK Gene
- HGNC: 5044
- Entrez Gene: 3190
- Ensembl: ENSG00000165119
- OMIM: 600712
- UniProtKB: P61978
Previous HGNC Symbols for HNRNPK Gene
- HNRPK
Previous GeneCards Identifiers for HNRNPK Gene
- GC09M085775
- GC09M086582
- GC09M056408
Summaries for HNRNPK Gene
-
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNRNPK Gene
HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K) is a Protein Coding gene. Diseases associated with HNRNPK include Au-Kline Syndrome and Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Hip Dysplasia Syndrome Due To 9Q21 Microdeletion. Among its related pathways are mRNA Splicing - Major Pathway and Influenza A. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP3.
UniProtKB/Swiss-Prot for HNRNPK Gene
-
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPK Gene
Genomics for HNRNPK Gene
Regulatory Elements for HNRNPK Gene
Enhancers for HNRNPK Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH09G083508 | 0.9 | FANTOM5 ENCODE dbSUPER | 1.7 | +472.4 | 472434 | 0.2 | L3MBTL2 | KIF27 HNRNPK UBQLN1 PIR58953 GC09M083513 GC09M083455 |
| GH09G083977 | 1.4 | ENCODE dbSUPER | 0.7 | +0.6 | 598 | 5.5 | HNRNPUL1 PKNOX1 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 | C9orf64 KIF27 LOC105376116 IDNK RMI1 GKAP1 HNRNPK ENSG00000235298 |
| GH09G083972 | 0.4 | dbSUPER | 0.4 | +8.2 | 8198 | 0.9 | PAF1 | ENSG00000235298 HNRNPK |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HNRNPK on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HNRNPK gene promoter:
Regulatory Element Products
Genomic Location for HNRNPK Gene
- Chromosome:
- 9
- Start:
- 83,968,083 bp from pter
- End:
- 83,980,654 bp from pter
- Size:
- 12,572 bases
- Orientation:
- Minus strand
Genomic View for HNRNPK Gene
Genes around HNRNPK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q21.32 by Ensembl
- 9q21.32 by Entrez Gene
- 9q21.32 by HGNC
HNRNPK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPK Gene
Proteins for HNRNPK Gene
-
Protein details for HNRNPK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P61978-HNRPK_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoprotein K
- Protein Accession:
- P61978
- Q07244
- Q15671
- Q59F98
- Q5T6W4
- Q60577
- Q922Y7
- Q96J62
Protein attributes for HNRNPK Gene
- Size:
- 463 amino acids
- Molecular mass:
- 50976 Da
- Quaternary structure:
-
- Interacts with RBM42 and ZIK1. Interacts with BRDT (By similarity). Identified in the spliceosome C complex. Interacts with ANKRD28. Interacts with HCV core protein. Interacts with ASFV p30 protein. Interacts with DDX1. Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation. Interacts with p53/TP53.
- SequenceCaution:
-
- Sequence=BAD92799.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for HNRNPK Gene
Alternative splice isoforms for HNRNPK Gene
- UniProtKB/Swiss-Prot:
Protein Expression for HNRNPK Gene
Post-translational modifications for HNRNPK Gene
- Arg-296 and Arg-299 are dimethylated, probably to asymmetric dimethylarginine.
- O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
- Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions.
- Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK poly-ubiquitination.
- Ubiquitination at isoforms=2, 334, isoforms=2, 352, isoforms=2, 3163, isoforms=2, 3179, posLast=198198, isoforms=456, and isoforms=461
- Modification sites at PhosphoSitePlus
Other Protein References for HNRNPK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HNRNPK
- Cell Signaling Technology (CST) Antibodies for HNRNPK (hnRNP K)
-
Custom Antibody ServicesOriGene Antibodies for HNRNPK
- Novus Biologicals Antibodies for HNRNPK
- Invitrogen Antibodies for HNRNPK
- antibodies-online Antibodies for HNRNPK: See all 115
- GeneTex HNRNPK antibody for HNRNPK
-
Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPK
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HNRNPK
- Origene Custom Protein Services for HNRNPK
- ProSpec Recombinant Proteins for HNRNPK
- antibodies-online Proteins for HNRNPK: See all 17
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HNRNPK
Assay Products
- antibodies-online Kits for HNRNPK: See all 35
No data available for DME Specific Peptides for HNRNPK Gene
Domains & Families for HNRNPK Gene
Protein Domains for HNRNPK Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPK Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ53312, highly similar to Heterogeneous nuclear ribonucleoprotein K (B4DFF1_HUMAN)
- Transformation up-regulated nuclear protein (HNRPK_HUMAN)
- Heterogeneous nuclear ribonucleoprotein K transcript variant (Q5EC54_HUMAN)
- cDNA FLJ77137, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein K (HNRPK), transcript variant 1, mRNA (Q6IBN1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for HNRNPK Gene
Function for HNRNPK Gene
Molecular function for HNRNPK Gene
- UniProtKB/Swiss-Prot Function:
- One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
- UniProtKB/Swiss-Prot Induction:
- By DNA damage, including ionizing radiations and phleomycin treatment or UV irradiation. This induction requires ATM kinase activity (ionizing radiations and phleomycin) or ATR activity (UV irradiation). Up-regulation is due to protein stabilization. Constitutive protein levels are controlled by MDM2-mediated ubiquitination and degradation via the proteasome pathway.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IMP | 20371611 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | IMP | 20371611 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003697 | single-stranded DNA binding | TAS | 20371611 |
Phenotypes for HNRNPK Gene
- GenomeRNAi human phenotypes for HNRNPK:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased NF-kappaB reporter expression
- Increased G1 DNA content
- G0/1 arrest
- Increased number of mitotic cells
- Decreased homologous recombination repair frequency
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased cell number
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased lymphocytic choriomeningitis virus (LCMV) infection
- Increased viability with nutlin-3
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPK gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPK gene
- Search ViGene Biosciences for HNRNPK
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPK
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPK
- GenScript: Design CRISPR guide RNA sequences for HNRNPK
miRNA for HNRNPK Gene
- miRTarBase miRNAs that target HNRNPK
-
- hsa-mir-450a-5p (MIRT004345)
- hsa-mir-21-5p (MIRT005325)
- hsa-mir-877-3p (MIRT037186)
- hsa-mir-106b-3p (MIRT038583)
- hsa-mir-615-3p (MIRT040216)
- hsa-mir-503-5p (MIRT041102)
- hsa-mir-484 (MIRT042152)
- hsa-mir-328-3p (MIRT043787)
- hsa-mir-125b-5p (MIRT045940)
- hsa-mir-23b-3p (MIRT046352)
- hsa-mir-15b-5p (MIRT046389)
- hsa-mir-30c-5p (MIRT047832)
- hsa-mir-1260b (MIRT052770)
- hsa-mir-1229-3p (MIRT379534)
- hsa-mir-6511a-3p (MIRT379535)
- hsa-mir-6511b-3p (MIRT379536)
- hsa-mir-6784-3p (MIRT379537)
- hsa-mir-6862-3p (MIRT379538)
- hsa-mir-500b-3p (MIRT657329)
- hsa-mir-590-3p (MIRT657330)
- hsa-mir-5571-5p (MIRT657331)
- hsa-mir-649 (MIRT657332)
miRNA Products
- Search ViGene Biosciences for HNRNPK
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HNRNPK
- Browse OriGene Inhibitory RNA Products For HNRNPK
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPK gene
Clone Products
- Sino Biological Human cDNA Clone for HNRNPK
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HNRNPK
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for HNRNPK gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPK gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPK gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPK Gene
Localization for HNRNPK Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPK Gene
- Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53 (PubMed:16360036). In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear (PubMed:18775702).
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 4 |
| mitochondrion | 2 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA | 20371611 |
| GO:0002102 | podosome | IEA | -- |
| GO:0005634 | nucleus | TAS | 8107114 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IEA | -- |
Pathways & Interactions for HNRNPK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.50
.41
|
| 2 | Metabolism of proteins | ||
| 3 | SUMOylation |
.95
|
|
| 4 | Influenza A | ||
| 5 | MicroRNAs in cancer | ||
Pathways by source for HNRNPK Gene
1 Cell Signaling Technology pathway for HNRNPK Gene
1 BioSystems pathway for HNRNPK Gene
9 Reactome pathways for HNRNPK Gene
4 KEGG pathways for HNRNPK Gene
1 Qiagen pathway for HNRNPK Gene
Interacting Proteins for HNRNPK Gene
Selected Interacting proteins:
ENSP00000365439
P61978-HNRPK_HUMAN
for HNRNPK Gene via
STRING
IID
UniProtKB
MINT
SIGNOR curated interactions for HNRNPK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA | -- |
Transcripts for HNRNPK Gene
mRNA/cDNA for HNRNPK Gene
- (12) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (96) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HNRNPK Gene
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPK
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPK
- GenScript: Design CRISPR guide RNA sequences for HNRNPK
miRNA Products
- Search ViGene Biosciences for HNRNPK
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HNRNPK
- Browse OriGene Inhibitory RNA Products For HNRNPK
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPK gene
Clone Products
- Sino Biological Human cDNA Clone for HNRNPK
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HNRNPK
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - |
Expression for HNRNPK Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPK Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HNRNPK Gene:
HNRNPKSOURCE GeneReport for Unigene cluster for HNRNPK Gene:
Hs.522257Evidence on tissue expression from TISSUES for HNRNPK Gene
- Nervous system(5)
- Liver(4.8)
- Muscle(4.5)
- Kidney(4.4)
- Skin(4.3)
- Blood(4.2)
- Lung(4.2)
- Intestine(4)
- Eye(3.9)
- Bone marrow(2.7)
- Heart(2.6)
- Stomach(2.4)
- Adrenal gland(2.2)
- Gall bladder(2.2)
- Lymph node(2.2)
- Pancreas(2.2)
- Spleen(2.2)
- Thyroid gland(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for HNRNPK
-
OriGene qPCR primer pairs for HNRNPK
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPK Gene
Orthologs for HNRNPK Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | HNRNPK 35 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | HNRNPK 34 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| HNRNPK 34 |
|
||||
| mouse (Mus musculus) |
Mammalia | Gm7964 35 |
|
OneToMany | |
| Hnrnpk 34 16 35 |
|
||||
| cow (Bos Taurus) |
Mammalia | HNRNPK 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HNRNPK 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hnrnpk 34 |
|
||
| chicken (Gallus gallus) |
Aves | HNRPK 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | HNRNPK 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | MGC75642 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | hnrpk-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hnrpkl 35 |
|
OneToMany | |
| hnrnpk 35 |
|
OneToMany | |||
| Dr.24225 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8484 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | bl 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | F26B1.2 35 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PBP2 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for HNRNPK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HNRNPK Gene
(3) SIMAP similar genes for HNRNPK Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for HNRNPK Gene
Variants for HNRNPK Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs767454980 | Pathogenic | 83,970,273(+) | CTCCC(A/G/T)ACTCA | upstream-variant-2KB, reference, missense, stop-gained | |
| rs863223402 | Pathogenic | 83,971,880(-) | GGGGG(-/G)TAAGT | splice-donor-variant | |
| rs863223403 | Pathogenic | 83,975,462(-) | CGAGC(A/G)GTATG | reference, missense | |
| rs879255263 | Pathogenic | 83,971,903(-) | TCCTC(-/TT)CACCA | reference, frameshift-variant | |
| rs886041807 | Pathogenic | 83,972,055(-) | GGTGG(-/G)TTTTG | reference, frameshift-variant |
Residual Variation Intolerance Score:
12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.22;
5.02% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HNRNPK Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPK Gene
Disorders for HNRNPK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| au-kline syndrome |
|
|
| neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-hip dysplasia syndrome due to 9q21 microdeletion |
|
|
| spinocerebellar ataxia 10 |
|
|
| stomatitis |
|
|
| hepatitis c virus |
|
|
Search HNRNPK in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HNRPK_HUMAN- Au-Kline syndrome (AUKS) [MIM:616580]: A disorder characterized by intellectual disability, facial dysmorphism, cardiac defects, and connective tissue and skeletal abnormalities. Dysmorphic features include long palpebral fissures, ptosis, a broad prominent nasal bridge, hypoplastic alae nasi, an open downturned mouth, ears with underdeveloped and thick helices, high palate, and a unique tongue with a prominent median crease. Hypotonia, hyporeflexia, and high pain tolerance are additional features. {ECO:0000269 PubMed:26173930}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for HNRNPK
No data available for Genatlas for HNRNPK Gene
Publications for HNRNPK Gene
- PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K. (PMID: 16564677) Kwiek N.C. … Haystead T.A.J. (Cell. Signal. 2006) 3 4 22 64
- hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. (PMID: 16360036) Moumen A. … Jackson S.P. (Cell 2005) 3 4 22 64
- Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K. (PMID: 9651361) Hsieh T.-Y. … Lai M.M.C. (J. Biol. Chem. 1998) 3 4 22 64
- Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing. (PMID: 8107114) Dejgaard K. … Celis J.E. (J. Mol. Biol. 1994) 2 3 4 64
- Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein. (PMID: 1729596) Matunis M.J. … Dreyfuss G. (Mol. Cell. Biol. 1992) 3 4 22 64
Products for HNRNPK Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for HNRNPK
- Browse OriGene ELISA Kits
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- Search Origene for MassSpec and Protein Over-expression Lysates for HNRNPK
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- GenScript: Next-day shipping cDNA ORF clone for HNRNPK in any vector
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- Novus Biologicals Antibodies for HNRNPK
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- ProSpec Recombinant Proteins for HNRNPK
- Addgene plasmids for HNRNPK
- antibodies-online Antibodies for HNRNPK: See all 115
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- antibodies-online Proteins for HNRNPK: See all 17
- Search antibodies-online for peptides
- GeneTex HNRNPK antibody for HNRNPK
- Search GeneTex for Proteins for HNRNPK
- ViGene Biosciences adenoviral particle packaged cDNA for HNRNPK gene
- ViGene Biosciences lentiviral particle packaged cDNA for HNRNPK gene
- ViGene Biosciences ready-to-package AAV shRNAs for HNRNPK gene
- Search ViGene Biosciences for HNRNPK
- Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPK
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- Cyagen custom Knockout/knockin (KOKI) mouse models for HNRNPK
- VectorBuilder custom plasmid, inducible vectors for HNRNPK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HNRNPK
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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