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Aliases for HNRNPK Gene

Aliases for HNRNPK Gene

  • Heterogeneous Nuclear Ribonucleoprotein K 2 3
  • HNRPK 3 4 6
  • Transformation Upregulated Nuclear Protein 2 3
  • TUNP 3 4
  • Transformation Up-Regulated Nuclear Protein 4
  • DC-Stretch Binding Protein 3
  • HnRNP K 4
  • CSBP 3

External Ids for HNRNPK Gene

Previous HGNC Symbols for HNRNPK Gene

  • HNRPK

Previous GeneCards Identifiers for HNRNPK Gene

  • GC09M085775
  • GC09M086582
  • GC09M056408

Summaries for HNRNPK Gene

Entrez Gene Summary for HNRNPK Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPK Gene

HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K) is a Protein Coding gene. Diseases associated with HNRNPK include spinocerebellar ataxia 10. Among its related pathways are MicroRNAs in cancer and Translational Control. GO annotations related to this gene include RNA binding and single-stranded DNA binding. An important paralog of this gene is PCBP3.

UniProtKB/Swiss-Prot for HNRNPK Gene

  • One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

Gene Wiki entry for HNRNPK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPK Gene

Genomics for HNRNPK Gene

Regulatory Elements for HNRNPK Gene

Genomic Location for HNRNPK Gene

Start:
83,968,083 bp from pter
End:
83,980,660 bp from pter
Size:
12,578 bases
Orientation:
Minus strand

Genomic View for HNRNPK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPK Gene

Proteins for HNRNPK Gene

  • Protein details for HNRNPK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61978-HNRPK_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein K
    Protein Accession:
    P61978
    Secondary Accessions:
    • Q07244
    • Q15671
    • Q59F98
    • Q5T6W4
    • Q60577
    • Q922Y7
    • Q96J62

    Protein attributes for HNRNPK Gene

    Size:
    463 amino acids
    Molecular mass:
    50976 Da
    Quaternary structure:
    • Interacts with RBM42 and ZIK1. Interacts with BRDT (By similarity). Identified in the spliceosome C complex. Interacts with ANKRD28. Interacts with HCV core protein. Interacts with ASFV p30 protein. Interacts with DDX1. Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation. Interacts with p53/TP53.
    SequenceCaution:
    • Sequence=BAD92799.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPK Gene

    Alternative splice isoforms for HNRNPK Gene

neXtProt entry for HNRNPK Gene

Proteomics data for HNRNPK Gene at MOPED

Post-translational modifications for HNRNPK Gene

  • Arg-296 and Arg-299 are dimethylated, probably to asymmetric dimethylarginine
  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions.
  • Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK poly-ubiquitination.
  • Ubiquitination at Lys34, Lys52, Lys163, Lys179, Lys198, Lys219, Lys405, Lys422, Lys456, and Lys461
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPK Gene

No data available for DME Specific Peptides for HNRNPK Gene

Domains for HNRNPK Gene

Protein Domains for HNRNPK Gene

Suggested Antigen Peptide Sequences for HNRNPK Gene

Graphical View of Domain Structure for InterPro Entry

P61978

UniProtKB/Swiss-Prot:

HNRPK_HUMAN :
  • P61978
Domain:
  • Contains 3 KH domains.
genes like me logo Genes that share domains with HNRNPK: view

No data available for Gene Families for HNRNPK Gene

Function for HNRNPK Gene

Molecular function for HNRNPK Gene

UniProtKB/Swiss-Prot Function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
UniProtKB/Swiss-Prot Induction: By DNA damage, including ionizing radiations and phleomycin treatment or UV irradiation. This induction requires ATM kinase activity (ionizing radiations and phleomycin) or ATR activity (UV irradiation). Up-regulation is due to protein stabilization. Constitutive protein levels are controlled by MDM2-mediated ubiquitination and degradation via the proteasome pathway.

Gene Ontology (GO) - Molecular Function for HNRNPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP 20371611
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP 20371611
GO:0003676 nucleic acid binding --
GO:0003697 single-stranded DNA binding TAS 20371611
GO:0003723 RNA binding TAS 8107114
genes like me logo Genes that share ontologies with HNRNPK: view
genes like me logo Genes that share phenotypes with HNRNPK: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPK Gene

Localization for HNRNPK Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPK Gene

Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53. In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPK Gene COMPARTMENTS Subcellular localization image for HNRNPK gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HNRNPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 20371611
GO:0002102 podosome IEA --
GO:0005634 nucleus TAS 16130169
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HNRNPK: view

Pathways for HNRNPK Gene

genes like me logo Genes that share pathways with HNRNPK: view

Pathways by source for HNRNPK Gene

1 Qiagen pathway for HNRNPK Gene
1 Cell Signaling Technology pathway for HNRNPK Gene
2 BioSystems pathways for HNRNPK Gene

Gene Ontology (GO) - Biological Process for HNRNPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006396 RNA processing TAS 8107114
GO:0007165 signal transduction TAS 16130169
GO:0008380 RNA splicing TAS --
genes like me logo Genes that share ontologies with HNRNPK: view

Compounds for HNRNPK Gene

(3) Novoseek inferred chemical compound relationships for HNRNPK Gene

Compound -log(P) Hits PubMed IDs
poly c 65.8 1
tyrosine 35.8 4
cytosine 18.7 2
genes like me logo Genes that share compounds with HNRNPK: view

Transcripts for HNRNPK Gene

Unigene Clusters for HNRNPK Gene

Heterogeneous nuclear ribonucleoprotein K:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPK Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18
SP1: -
SP2:
SP3:
SP4: - - - - - - - - - - -
SP5: -
SP6:
SP7:
SP8:
SP9: -

Relevant External Links for HNRNPK Gene

GeneLoc Exon Structure for
HNRNPK
ECgene alternative splicing isoforms for
HNRNPK

Expression for HNRNPK Gene

mRNA expression in normal human tissues for HNRNPK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPK Gene

SOURCE GeneReport for Unigene cluster for HNRNPK Gene Hs.522257

genes like me logo Genes that share expressions with HNRNPK: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPK Gene

Orthologs for HNRNPK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPK 35
  • 99.78 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia HNRNPK 35
  • 96.55 (n)
  • 99.78 (a)
HNRNPK 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 98 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
HNRNPK 35
  • 96.19 (n)
  • 99.14 (a)
mouse
(Mus musculus)
Mammalia Gm7964 36
  • 98 (a)
OneToMany
Hnrnpk 35
  • 93.75 (n)
  • 99.78 (a)
Hnrnpk 16
Hnrnpk 36
  • 99 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia HNRNPK 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnpk 35
  • 94.05 (n)
  • 99.78 (a)
chicken
(Gallus gallus)
Aves HNRPK 36
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HNRNPK 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hnrpk-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75642 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8484 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24225 35
hnrnpk 36
  • 72 (a)
OneToMany
hnrpkl 36
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta bl 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F26B1.2 36
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBP2 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for HNRNPK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPK Gene

ENSEMBL:
Gene Tree for HNRNPK (if available)
TreeFam:
Gene Tree for HNRNPK (if available)

Paralogs for HNRNPK Gene

Paralogs for HNRNPK Gene

Selected SIMAP similar genes for HNRNPK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HNRNPK: view

Variants for HNRNPK Gene

Sequence variations from dbSNP and Humsavar for HNRNPK Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs14961 -- 83,969,116(-) TTTTT(C/T)GTTAT utr-variant-3-prime
rs167202 -- 83,972,428(-) AAGCT(A/G)TTACT intron-variant
rs167203 -- 83,978,399(-) CAGTT(C/G)TGCTC utr-variant-5-prime
rs192705 -- 83,976,789(-) TCTTT(C/T)AAACC intron-variant
rs296884 -- 83,968,008(-) ATTAA(A/C)GTGGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HNRNPK Gene

Variant ID Type Subtype PubMed ID
nsv469859 CNV Complex 16826518
dgv2394e1 CNV Complex 17122850
nsv8541 CNV Gain 18304495
nsv436717 OTHER Inversion 17901297
nsv831644 CNV Gain 17160897
nsv893514 CNV Gain 21882294

Relevant External Links for HNRNPK Gene

HapMap Linkage Disequilibrium report
HNRNPK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPK Gene

Disorders for HNRNPK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HNRNPK Gene including...

Search for HNRNPK Gene in MalaCards »

(7) Novoseek inferred disease relationships for HNRNPK Gene

Disease -log(P) Hits PubMed IDs
colorectal cancer 16.4 1
mental retardation 4.26 2
carcinoma squamous cell 0 2
shock 0 2
tumors 0 2

Relevant External Links for HNRNPK

Human Genome Epidemiology (HuGE) Navigator
HNRNPK
genes like me logo Genes that share disorders with HNRNPK: view

No data available for UniProtKB/Swiss-Prot for HNRNPK Gene

Publications for HNRNPK Gene

  1. Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein. (PMID: 1729596) Matunis M.J. … Dreyfuss G. (Mol. Cell. Biol. 1992) 3 4 23
  2. Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K. (PMID: 9651361) Hsieh T.-Y. … Lai M.M.C. (J. Biol. Chem. 1998) 3 4 23
  3. hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. (PMID: 16360036) Moumen A. … Jackson S.P. (Cell 2005) 3 4 23
  4. PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K. (PMID: 16564677) Kwiek N.C. … Haystead T.A.J. (Cell. Signal. 2006) 3 4 23
  5. Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing. (PMID: 8107114) Dejgaard K. … Celis J.E. (J. Mol. Biol. 1994) 2 3 4

Products for HNRNPK Gene

Sources for HNRNPK Gene

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