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Aliases for HNRNPH3 Gene

Aliases for HNRNPH3 Gene

  • Heterogeneous Nuclear Ribonucleoprotein H3 (2H9) 2 3
  • HNRPH3 3 4 6
  • Heterogeneous Nuclear Ribonucleoprotein 2H9 3 4
  • HnRNP 2H9 3 4
  • HnRNP H3 3 4
  • 2H9 3 6
  • Heterogeneous Nuclear Ribonucleoprotein H3 3

External Ids for HNRNPH3 Gene

Previous Symbols for HNRNPH3 Gene

  • HNRPH3

Summaries for HNRNPH3 Gene

Entrez Gene Summary for HNRNPH3 Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPH3 Gene

HNRNPH3 (Heterogeneous Nuclear Ribonucleoprotein H3 (2H9)) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is ESRP2.

UniProtKB/Swiss-Prot for HNRNPH3 Gene

  • Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction

Gene Wiki entry for HNRNPH3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPH3 Gene

Genomics for HNRNPH3 Gene

Genomic Location for HNRNPH3 Gene

Start:
68,331,174 bp from pter
End:
68,343,196 bp from pter
Size:
12,023 bases
Orientation:
Plus strand

Genomic View for HNRNPH3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPH3 Gene

Regulatory Elements for HNRNPH3 Gene

Proteins for HNRNPH3 Gene

  • Protein details for HNRNPH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31942-HNRH3_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein H3
    Protein Accession:
    P31942
    Secondary Accessions:
    • A8K682
    • B3KRE1
    • Q9BSX1
    • Q9NP53
    • Q9NP96
    • Q9NPA7
    • Q9NPI4
    • Q9UFU4
    • Q9Y4J5

    Protein attributes for HNRNPH3 Gene

    Size:
    346 amino acids
    Molecular mass:
    36926 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HNRNPH3 Gene

neXtProt entry for HNRNPH3 Gene

Proteomics data for HNRNPH3 Gene at MOPED

Post-translational modifications for HNRNPH3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys67

Other Protein References for HNRNPH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPH3 Gene

Domains for HNRNPH3 Gene

Gene Families for HNRNPH3 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for HNRNPH3 Gene

Suggested Antigen Peptide Sequences for HNRNPH3 Gene

Graphical View of Domain Structure for InterPro Entry

P31942

UniProtKB/Swiss-Prot:

HNRH3_HUMAN
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.:
    • P31942
genes like me logo Genes that share domains with HNRNPH3: view

Function for HNRNPH3 Gene

Molecular function for HNRNPH3 Gene

UniProtKB/Swiss-Prot Function: Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction

Gene Ontology (GO) - Molecular Function for HNRNPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 10858537
GO:0005515 protein binding IPI 22720776
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HNRNPH3: view

Phenotypes for HNRNPH3 Gene

genes like me logo Genes that share phenotypes with HNRNPH3: view

miRNA for HNRNPH3 Gene

miRTarBase miRNAs that target HNRNPH3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPH3 Gene

Localization for HNRNPH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPH3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPH3 Gene COMPARTMENTS Subcellular localization image for HNRNPH3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for HNRNPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex TAS 8999868
genes like me logo Genes that share ontologies with HNRNPH3: view

Pathways for HNRNPH3 Gene

SuperPathways for HNRNPH3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HNRNPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome NAS 10858537
GO:0006396 RNA processing TAS 8999868
GO:0008380 RNA splicing TAS 8999868
GO:0030855 epithelial cell differentiation IEP 21492153
genes like me logo Genes that share ontologies with HNRNPH3: view

No data available for Pathways by source for HNRNPH3 Gene

Transcripts for HNRNPH3 Gene

Unigene Clusters for HNRNPH3 Gene

Heterogeneous nuclear ribonucleoprotein H3 (2H9):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPH3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ·
SP1: - - - - - - - - -
SP2: - - -
SP3:
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - -
SP8:
SP9: - - - - - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - - - -
SP18: - - - - - -
SP19: - - - - - -
SP20: - -
SP21: - - -
SP22: - -
SP23: - - - - -

ExUns: 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7: -
SP8: -
SP9: -
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23:

Relevant External Links for HNRNPH3 Gene

GeneLoc Exon Structure for
HNRNPH3
ECgene alternative splicing isoforms for
HNRNPH3

Expression for HNRNPH3 Gene

mRNA expression in normal human tissues for HNRNPH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPH3 Gene

SOURCE GeneReport for Unigene cluster for HNRNPH3 Gene Hs.643472

genes like me logo Genes that share expressions with HNRNPH3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPH3 Gene

Orthologs for HNRNPH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPH3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPH3 35
  • 99.71 (n)
  • 100 (a)
HNRNPH3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
HNRNPH3 35
  • 97.48 (n)
  • 99.68 (a)
dog
(Canis familiaris)
Mammalia HNRNPH3 35
  • 97.01 (n)
  • 100 (a)
HNRNPH3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnph3 35
  • 94.99 (n)
  • 99.42 (a)
Hnrnph3 16
Hnrnph3 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPH3 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPH3 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910795 35
  • 95.86 (n)
  • 99.42 (a)
chicken
(Gallus gallus)
Aves HNRNPH3 35
  • 84.63 (n)
  • 90.58 (a)
HNRNPH3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPH3 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5236 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14128 35
zebrafish
(Danio rerio)
Actinopterygii HNRNPH3 36
  • 52 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for HNRNPH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPH3 Gene

ENSEMBL:
Gene Tree for HNRNPH3 (if available)
TreeFam:
Gene Tree for HNRNPH3 (if available)

Paralogs for HNRNPH3 Gene

Paralogs for HNRNPH3 Gene

Selected SIMAP similar genes for HNRNPH3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for HNRNPH3 Gene

genes like me logo Genes that share paralogs with HNRNPH3: view

Variants for HNRNPH3 Gene

Sequence variations from dbSNP and Humsavar for HNRNPH3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1162757 -- 68,340,598(-) GCTTT(C/T)AAAGC intron-variant
rs1162758 -- 68,340,439(-) CAACA(A/G)CAGCA intron-variant
rs1162759 -- 68,340,394(-) ATCAC(C/T)ATCTA intron-variant
rs1162760 -- 68,338,889(-) TCTTA(A/T)TTTTA intron-variant
rs1162761 -- 68,337,524(-) ATTAA(C/T)TAGGT intron-variant

Relevant External Links for HNRNPH3 Gene

HapMap Linkage Disequilibrium report
HNRNPH3
Human Gene Mutation Database (HGMD)
HNRNPH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HNRNPH3 Gene

Disorders for HNRNPH3 Gene

Relevant External Links for HNRNPH3

Genetic Association Database (GAD)
HNRNPH3
Human Genome Epidemiology (HuGE) Navigator
HNRNPH3
genes like me logo Genes that share disorders with HNRNPH3: view

No data available for UniProtKB/Swiss-Prot for HNRNPH3 Gene

Publications for HNRNPH3 Gene

  1. Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest. (PMID: 8999868) Mahe D. … Fuchs J.-P. (J. Biol. Chem. 1997) 2 3 4 23
  2. The hnRNP 2H9 gene, which is involved in the splicing reaction, is a multiply spliced gene. (PMID: 10858537) Honore B. (Biochim. Biophys. Acta 2000) 3 4 23
  3. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PMID: 1286667) Rasmussen H.H. … Vandekerckhove J. (Electrophoresis 1992) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HNRNPH3 Gene

Sources for HNRNPH3 Gene

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