Aliases for HNRNPH3 Gene
Aliases for HNRNPH3 Gene
External Ids for HNRNPH3 Gene
- HGNC: 5043
- Entrez Gene: 3189
- Ensembl: ENSG00000096746
- OMIM: 602324
- UniProtKB: P31942
Previous HGNC Symbols for HNRNPH3 Gene
- HNRPH3
Previous GeneCards Identifiers for HNRNPH3 Gene
- GC10P069762
- GC10P070090
- GC10P064093
Summaries for HNRNPH3 Gene
-
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNRNPH3 Gene
HNRNPH3 (Heterogeneous Nuclear Ribonucleoprotein H3) is a Protein Coding gene. Diseases associated with HNRNPH3 include Lymphatic System Cancer. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPH1.
UniProtKB/Swiss-Prot for HNRNPH3 Gene
-
Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPH3 Gene
Genomics for HNRNPH3 Gene
Regulatory Elements for HNRNPH3 Gene
Regulatory Element Products
Genomic Location for HNRNPH3 Gene
- Chromosome:
- 10
- Start:
- 68,331,174 bp from pter
- End:
- 68,343,196 bp from pter
- Size:
- 12,023 bases
- Orientation:
- Plus strand
Genomic View for HNRNPH3 Gene
- Cytogenetic band:
-
- 10q21.3 by Ensembl
- 10q21.3 by Entrez Gene
- 10q21.3 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPH3 Gene
Proteins for HNRNPH3 Gene
-
Protein details for HNRNPH3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31942-HNRH3_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoprotein H3
- Protein Accession:
- P31942
- A8K682
- B3KRE1
- Q9BSX1
- Q9NP53
- Q9NP96
- Q9NPA7
- Q9NPI4
- Q9UFU4
- Q9Y4J5
Protein attributes for HNRNPH3 Gene
- Size:
- 346 amino acids
- Molecular mass:
- 36926 Da
- Quaternary structure:
- No Data Available
Protein Expression for HNRNPH3 Gene
Post-translational modifications for HNRNPH3 Gene
Other Protein References for HNRNPH3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001309363.1
- NP_001309365.1
- NP_001309366.1
- NP_001309367.1
- NP_001309368.1
- NP_001309369.1
- NP_001309370.1
- NP_001309371.1
- NP_001309372.1
- NP_001309373.1
- NP_001309374.1
- NP_001309375.1
- NP_001309376.1
- NP_001309377.1
- NP_001309378.1
- NP_001309379.1
- NP_001309380.1
- NP_001309381.1
- NP_001309382.1
- NP_036339.1
- NP_067676.2
- XP_011538044.1
- XP_016871657.1
- XP_016871658.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HNRNPH3
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- antibodies-online Antibodies for HNRNPH3: See all 23
- GeneTex HNRNPH3 antibody for HNRNPH3
-
Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPH3
Protein Products
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- antibodies-online Proteins for HNRNPH3: See all 3
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Assay Products
No data available for DME Specific Peptides for HNRNPH3 Gene
Domains & Families for HNRNPH3 Gene
Gene Families for HNRNPH3 Gene
Protein Domains for HNRNPH3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPH3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HNRNPH3 Gene
Function for HNRNPH3 Gene
Molecular function for HNRNPH3 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | TAS,NAS | 10858537 |
| GO:0005515 | protein binding | IPI | 22365833 |
Phenotypes for HNRNPH3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPH3 gene
-
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CRISPR Products
-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPH3
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miRNA for HNRNPH3 Gene
- miRTarBase miRNAs that target HNRNPH3
miRNA Products
- Search ViGene Biosciences for HNRNPH3
Inhibitory RNA Products
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-
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Clone Products
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Cell Line Products
-
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-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPH3 Gene
Localization for HNRNPH3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPH3 Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IDA | 22720776 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005681 | spliceosomal complex | TAS | 8999868 |
| GO:0019013 | viral nucleocapsid | IEA | -- |
| GO:0030529 | intracellular ribonucleoprotein complex | IEA | -- |
Pathways & Interactions for HNRNPH3 Gene
Interacting Proteins for HNRNPH3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | NAS | 10858537 |
| GO:0006396 | RNA processing | TAS | 8999868 |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | TAS | 8999868 |
| GO:0030855 | epithelial cell differentiation | IEP | 21492153 |
No data available for Pathways by source and SIGNOR curated interactions for HNRNPH3 Gene
Transcripts for HNRNPH3 Gene
mRNA/cDNA for HNRNPH3 Gene
- (24) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (395) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HNRNPH3 Gene
CRISPR Products
-
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-
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
- Sino Biological Human cDNA Clone for HNRNPH3
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Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | · | 2h | · | 2i | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | · | 8d | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | - | - | - |
| ExUns: | 8e | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||
| SP11: | - | ||||||||||||||||||||
| SP12: | |||||||||||||||||||||
| SP13: | |||||||||||||||||||||
| SP14: | |||||||||||||||||||||
| SP15: | |||||||||||||||||||||
| SP16: | |||||||||||||||||||||
| SP17: | |||||||||||||||||||||
| SP18: | |||||||||||||||||||||
| SP19: | |||||||||||||||||||||
| SP20: | - | ||||||||||||||||||||
| SP21: | |||||||||||||||||||||
| SP22: | |||||||||||||||||||||
| SP23: |
Expression for HNRNPH3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPH3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HNRNPH3 Gene:
HNRNPH3SOURCE GeneReport for Unigene cluster for HNRNPH3 Gene:
Hs.643472Evidence on tissue expression from TISSUES for HNRNPH3 Gene
- Nervous system(4.9)
- Liver(4.5)
- Skin(4.4)
- Eye(2.6)
- Heart(2.5)
- Spleen(2.5)
- Kidney(2.4)
- Lung(2.4)
- Lymph node(2.4)
- Muscle(2.4)
- Bone marrow(2.1)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for HNRNPH3
-
OriGene qPCR primer pairs and template standards for HNRNPH3
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPH3 Gene
Orthologs for HNRNPH3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| HNRNPH3 34 |
|
||||
| -- 35 |
|
OneToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | HNRNPH3 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HNRNPH3 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HNRNPH3 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HNRNPH3 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hnrnph3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hnrnph3 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | HNRNPH3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HNRNPH3 35 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5236 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | HNRNPH3 35 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.14128 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HNRNPH3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HNRNPH3 Gene
(6) SIMAP similar genes for HNRNPH3 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for HNRNPH3 Gene
Variants for HNRNPH3 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000183533 | -- | 68,340,139(+) | AAGTT(A/T)TTCTT | intron-variant | |
| rs1000242351 | -- | 68,340,406(+) | AGAAA(C/T)TGAGG | intron-variant | |
| rs1000292075 | -- | 68,332,632(+) | AAGGG(A/T)TGAGG | intron-variant, upstream-variant-2KB | |
| rs1000725840 | -- | 68,332,461(+) | GGGAC(A/G)TCCAG | intron-variant, upstream-variant-2KB | |
| rs1000742449 | -- | 68,333,089(+) | ATTTG(A/G)AACTT | intron-variant, upstream-variant-2KB, utr-variant-5-prime |
Relevant External Links for HNRNPH3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPH3 Gene
Disorders for HNRNPH3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphatic system cancer |
|
|
Relevant External Links for HNRNPH3
No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPH3 Gene
Publications for HNRNPH3 Gene
- Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest. (PMID: 8999868) Mahe D. … Fuchs J.-P. (J. Biol. Chem. 1997) 2 3 4 22 64
- The hnRNP 2H9 gene, which is involved in the splicing reaction, is a multiply spliced gene. (PMID: 10858537) Honore B. (Biochim. Biophys. Acta 2000) 3 4 22 64
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
Products for HNRNPH3 Gene
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- Novus Biologicals Antibodies for HNRNPH3
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- Novus Biologicals
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- antibodies-online Antibodies for HNRNPH3: See all 23
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- antibodies-online Proteins for HNRNPH3: See all 3
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- GeneTex HNRNPH3 antibody for HNRNPH3
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- ViGene Biosciences adenoviral particle packaged cDNA for HNRNPH3 gene
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- VectorBuilder custom plasmid, inducible vectors for HNRNPH3
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HNRNPH3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
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- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
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- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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- (85) SIMAP
- (86) GenomeRNAi
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- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
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- (112) GeneTex
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- (114) GTEx
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- (116) SCBT
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- (122) diseasecard
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




