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Aliases for HNRNPH3 Gene

Aliases for HNRNPH3 Gene

  • Heterogeneous Nuclear Ribonucleoprotein H3 2 3
  • Heterogeneous Nuclear Ribonucleoprotein H3 (2H9) 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein 2H9 2 3 4
  • HnRNP 2H9 3 4
  • HnRNP H3 3 4
  • HNRPH3 3 4
  • 2H9 3

External Ids for HNRNPH3 Gene

Previous HGNC Symbols for HNRNPH3 Gene

  • HNRPH3

Previous GeneCards Identifiers for HNRNPH3 Gene

  • GC10P069762
  • GC10P070090
  • GC10P064093

Summaries for HNRNPH3 Gene

Entrez Gene Summary for HNRNPH3 Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPH3 Gene

HNRNPH3 (Heterogeneous Nuclear Ribonucleoprotein H3) is a Protein Coding gene. Diseases associated with HNRNPH3 include lymphatic system cancer. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ESRP2.

UniProtKB/Swiss-Prot for HNRNPH3 Gene

  • Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.

Gene Wiki entry for HNRNPH3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPH3 Gene

Genomics for HNRNPH3 Gene

Regulatory Elements for HNRNPH3 Gene

Enhancers for HNRNPH3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HNRNPH3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HNRNPH3 Gene

Chromosome:
10
Start:
68,331,174 bp from pter
End:
68,343,196 bp from pter
Size:
12,023 bases
Orientation:
Plus strand

Genomic View for HNRNPH3 Gene

Genes around HNRNPH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPH3 Gene

Proteins for HNRNPH3 Gene

  • Protein details for HNRNPH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31942-HNRH3_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein H3
    Protein Accession:
    P31942
    Secondary Accessions:
    • A8K682
    • B3KRE1
    • Q9BSX1
    • Q9NP53
    • Q9NP96
    • Q9NPA7
    • Q9NPI4
    • Q9UFU4
    • Q9Y4J5

    Protein attributes for HNRNPH3 Gene

    Size:
    346 amino acids
    Molecular mass:
    36926 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HNRNPH3 Gene

neXtProt entry for HNRNPH3 Gene

Proteomics data for HNRNPH3 Gene at MOPED

Post-translational modifications for HNRNPH3 Gene

  • Ubiquitination at Lys 6 and Lys 67
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPH3 Gene

Domains & Families for HNRNPH3 Gene

Gene Families for HNRNPH3 Gene

Protein Domains for HNRNPH3 Gene

Suggested Antigen Peptide Sequences for HNRNPH3 Gene

Graphical View of Domain Structure for InterPro Entry

P31942

UniProtKB/Swiss-Prot:

HNRH3_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPH3: view

Function for HNRNPH3 Gene

Molecular function for HNRNPH3 Gene

UniProtKB/Swiss-Prot Function:
Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.

Gene Ontology (GO) - Molecular Function for HNRNPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with HNRNPH3: view
genes like me logo Genes that share phenotypes with HNRNPH3: view

Animal Model Products

miRNA for HNRNPH3 Gene

miRTarBase miRNAs that target HNRNPH3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPH3 Gene

Localization for HNRNPH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPH3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPH3 Gene COMPARTMENTS Subcellular localization image for HNRNPH3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for HNRNPH3 Gene

Pathways & Interactions for HNRNPH3 Gene

SuperPathways for HNRNPH3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HNRNPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 8999868
genes like me logo Genes that share ontologies with HNRNPH3: view

No data available for Pathways by source and SIGNOR curated interactions for HNRNPH3 Gene

Drugs & Compounds for HNRNPH3 Gene

No Compound Related Data Available

Transcripts for HNRNPH3 Gene

Unigene Clusters for HNRNPH3 Gene

Heterogeneous nuclear ribonucleoprotein H3 (2H9):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPH3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ·
SP1: - - - - - - - - -
SP2: - - -
SP3:
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - -
SP8:
SP9: - - - - - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - - - -
SP18: - - - - - -
SP19: - - - - - -
SP20: - -
SP21: - - -
SP22: - -
SP23: - - - - -

ExUns: 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7: -
SP8: -
SP9: -
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23:

Relevant External Links for HNRNPH3 Gene

GeneLoc Exon Structure for
HNRNPH3
ECgene alternative splicing isoforms for
HNRNPH3

Expression for HNRNPH3 Gene

mRNA expression in normal human tissues for HNRNPH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HNRNPH3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPH3 Gene



SOURCE GeneReport for Unigene cluster for HNRNPH3 Gene Hs.643472

genes like me logo Genes that share expression patterns with HNRNPH3: view

Protein tissue co-expression partners for HNRNPH3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPH3 Gene

Orthologs for HNRNPH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPH3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HNRNPH3 35
  • 97.48 (n)
  • 99.68 (a)
-- 36
  • 95 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HNRNPH3 35
  • 97.01 (n)
  • 100 (a)
HNRNPH3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnph3 35
  • 94.99 (n)
  • 99.42 (a)
Hnrnph3 16
Hnrnph3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HNRNPH3 35
  • 99.71 (n)
  • 100 (a)
HNRNPH3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910795 35
  • 95.86 (n)
  • 99.42 (a)
oppossum
(Monodelphis domestica)
Mammalia HNRNPH3 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPH3 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPH3 35
  • 84.63 (n)
  • 90.58 (a)
HNRNPH3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPH3 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5236 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14128 35
zebrafish
(Danio rerio)
Actinopterygii HNRNPH3 36
  • 52 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for HNRNPH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPH3 Gene

ENSEMBL:
Gene Tree for HNRNPH3 (if available)
TreeFam:
Gene Tree for HNRNPH3 (if available)

Paralogs for HNRNPH3 Gene

Paralogs for HNRNPH3 Gene

(6) SIMAP similar genes for HNRNPH3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for HNRNPH3 Gene

genes like me logo Genes that share paralogs with HNRNPH3: view

Variants for HNRNPH3 Gene

Sequence variations from dbSNP and Humsavar for HNRNPH3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2273903 - 68,339,191(+) TGGGA(A/G)TGATG reference, missense, utr-variant-5-prime
VAR_052226 -
rs2475878 -- 68,336,682(-) CACTA(C/G)AATTT intron-variant
rs2475879 -- 68,336,404(-) TAAAA(C/G)GTACA intron-variant
rs2475880 -- 68,336,403(-) AAAAG(C/G)TACAT intron-variant

Variation tolerance for HNRNPH3 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPH3 Gene

HapMap Linkage Disequilibrium report
HNRNPH3
Human Gene Mutation Database (HGMD)
HNRNPH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HNRNPH3 Gene

Disorders for HNRNPH3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNRNPH3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lymphatic system cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HNRNPH3

Genetic Association Database (GAD)
HNRNPH3
Human Genome Epidemiology (HuGE) Navigator
HNRNPH3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPH3
genes like me logo Genes that share disorders with HNRNPH3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPH3 Gene

Publications for HNRNPH3 Gene

  1. Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest. (PMID: 8999868) Mahe D. … Fuchs J.-P. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. The hnRNP 2H9 gene, which is involved in the splicing reaction, is a multiply spliced gene. (PMID: 10858537) Honore B. (Biochim. Biophys. Acta 2000) 3 23
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for HNRNPH3 Gene

Sources for HNRNPH3 Gene

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