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Aliases for HNRNPH3 Gene

Aliases for HNRNPH3 Gene

  • Heterogeneous Nuclear Ribonucleoprotein H3 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein 2H9 2 3 4
  • HnRNP 2H9 3 4
  • HnRNP H3 3 4
  • HNRPH3 3 4
  • Heterogeneous Nuclear Ribonucleoprotein H3 (2H9) 2
  • 2H9 3

External Ids for HNRNPH3 Gene

Previous HGNC Symbols for HNRNPH3 Gene

  • HNRPH3

Previous GeneCards Identifiers for HNRNPH3 Gene

  • GC10P069762
  • GC10P070090
  • GC10P064093

Summaries for HNRNPH3 Gene

Entrez Gene Summary for HNRNPH3 Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPH3 Gene

HNRNPH3 (Heterogeneous Nuclear Ribonucleoprotein H3) is a Protein Coding gene. Diseases associated with HNRNPH3 include Lymphatic System Cancer. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPH2.

UniProtKB/Swiss-Prot for HNRNPH3 Gene

  • Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.

Gene Wiki entry for HNRNPH3 Gene

Additional gene information for HNRNPH3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPH3 Gene

Genomics for HNRNPH3 Gene

GeneHancer (GH) Regulatory Elements for HNRNPH3 Gene

Promoters and enhancers for HNRNPH3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I068327 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 595.7 +1.1 1096 9.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 HNRNPH3 PBLD DDX50 HERC4 CCAR1 SIRT1 DNA2 RPL26P27 TET1 RPS3AP38
GH10I069179 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 45.6 +849.5 849485 3.3 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SUPV3L1 CCAR1 DDX50 HNRNPH3 TYSND1 SAR1A DDX21 RPL26P27 VPS26A HKDC1
GH10I068119 Enhancer 0.8 dbSUPER 90.1 -211.3 -211326 1.1 ZNF529 ZFP64 MZF1 ZNF213 ZNF354C ZNF138 ZNF202 ZNF680 ZBTB11 ZC3H11A CCAR1 HNRNPH3 DDX50 SIRT1 HERC4 TET1 KIF1BP RUFY2 ENSG00000260400 RPL26P27
GH10I069122 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 24.5 +793.3 793275 3.1 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 VPS26A CCAR1 DDX50 HNRNPH3 RPL26P27 SUPV3L1 LOC101928994 HKDC1 SRGN DDX21
GH10I068526 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.9 +196.1 196122 2.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 SLC25A16 DDX50 DNA2 CCAR1 HNRNPH3 HERC4 SIRT1 RPL26P27 SUPV3L1 MIR1254-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HNRNPH3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HNRNPH3 gene promoter:

Genomic Locations for HNRNPH3 Gene

Genomic Locations for HNRNPH3 Gene
chr10:68,331,174-68,343,196
(GRCh38/hg38)
Size:
12,023 bases
Orientation:
Plus strand
chr10:70,090,931-70,102,953
(GRCh37/hg19)

Genomic View for HNRNPH3 Gene

Genes around HNRNPH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPH3 Gene

Proteins for HNRNPH3 Gene

  • Protein details for HNRNPH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31942-HNRH3_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein H3
    Protein Accession:
    P31942
    Secondary Accessions:
    • A8K682
    • B3KRE1
    • Q9BSX1
    • Q9NP53
    • Q9NP96
    • Q9NPA7
    • Q9NPI4
    • Q9UFU4
    • Q9Y4J5

    Protein attributes for HNRNPH3 Gene

    Size:
    346 amino acids
    Molecular mass:
    36926 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HNRNPH3 Gene

neXtProt entry for HNRNPH3 Gene

Post-translational modifications for HNRNPH3 Gene

  • Ubiquitination at isoforms=26 and isoforms=2, 367

No data available for DME Specific Peptides for HNRNPH3 Gene

Domains & Families for HNRNPH3 Gene

Gene Families for HNRNPH3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HNRNPH3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPH3: view

No data available for UniProtKB/Swiss-Prot for HNRNPH3 Gene

Function for HNRNPH3 Gene

Molecular function for HNRNPH3 Gene

UniProtKB/Swiss-Prot Function:
Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.

Phenotypes From GWAS Catalog for HNRNPH3 Gene

Gene Ontology (GO) - Molecular Function for HNRNPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding TAS,NAS 10858537
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with HNRNPH3: view
genes like me logo Genes that share phenotypes with HNRNPH3: view

miRNA for HNRNPH3 Gene

miRTarBase miRNAs that target HNRNPH3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPH3 Gene

Localization for HNRNPH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPH3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPH3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 22720776
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex TAS 8999868
GO:0019013 viral nucleocapsid IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with HNRNPH3: view

Pathways & Interactions for HNRNPH3 Gene

SuperPathways for HNRNPH3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HNRNPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome NAS 10858537
GO:0006396 RNA processing TAS 8999868
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing TAS 8999868
GO:0030855 epithelial cell differentiation IEP 21492153
genes like me logo Genes that share ontologies with HNRNPH3: view

No data available for Pathways by source and SIGNOR curated interactions for HNRNPH3 Gene

Drugs & Compounds for HNRNPH3 Gene

(1) Drugs for HNRNPH3 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202
genes like me logo Genes that share compounds with HNRNPH3: view

Transcripts for HNRNPH3 Gene

Unigene Clusters for HNRNPH3 Gene

Heterogeneous nuclear ribonucleoprotein H3 (2H9):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPH3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ·
SP1: - - - - - - - - -
SP2: - - -
SP3:
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - -
SP8:
SP9: - - - - - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - - - -
SP18: - - - - - -
SP19: - - - - - -
SP20: - -
SP21: - - -
SP22: - -
SP23: - - - - -

ExUns: 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7: -
SP8: -
SP9: -
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23:

Relevant External Links for HNRNPH3 Gene

GeneLoc Exon Structure for
HNRNPH3
ECgene alternative splicing isoforms for
HNRNPH3

Expression for HNRNPH3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HNRNPH3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPH3 Gene



Protein tissue co-expression partners for HNRNPH3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPH3 Gene:

HNRNPH3

SOURCE GeneReport for Unigene cluster for HNRNPH3 Gene:

Hs.643472

Evidence on tissue expression from TISSUES for HNRNPH3 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Skin(4.4)
  • Eye(2.6)
  • Heart(2.5)
  • Spleen(2.5)
  • Kidney(2.4)
  • Lung(2.4)
  • Lymph node(2.4)
  • Muscle(2.4)
  • Bone marrow(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with HNRNPH3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPH3 Gene

Orthologs for HNRNPH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPH3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 34
  • 100 (a)
OneToMany
HNRNPH3 33
  • 97.48 (n)
-- 34
  • 95 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia HNRNPH3 33 34
  • 99.71 (n)
oppossum
(Monodelphis domestica)
Mammalia HNRNPH3 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPH3 33 34
  • 97.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPH3 34
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnph3 33
  • 95.86 (n)
mouse
(Mus musculus)
Mammalia Hnrnph3 33 16 34
  • 94.99 (n)
chicken
(Gallus gallus)
Aves HNRNPH3 33 34
  • 84.63 (n)
lizard
(Anolis carolinensis)
Reptilia HNRNPH3 34
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5236 33
zebrafish
(Danio rerio)
Actinopterygii HNRNPH3 34
  • 52 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14128 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToMany
Species where no ortholog for HNRNPH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPH3 Gene

ENSEMBL:
Gene Tree for HNRNPH3 (if available)
TreeFam:
Gene Tree for HNRNPH3 (if available)

Paralogs for HNRNPH3 Gene

Paralogs for HNRNPH3 Gene

(6) SIMAP similar genes for HNRNPH3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for HNRNPH3 Gene

genes like me logo Genes that share paralogs with HNRNPH3: view

Variants for HNRNPH3 Gene

Sequence variations from dbSNP and Humsavar for HNRNPH3 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000183533 -- 68,340,139(+) A/T intron_variant
rs1000242351 -- 68,340,406(+) C/T intron_variant
rs1000292075 -- 68,332,632(+) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000725840 -- 68,332,461(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000742449 -- 68,333,089(+) G/A 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPH3 Gene

Variant ID Type Subtype PubMed ID
nsv950972 CNV duplication 24416366

Variation tolerance for HNRNPH3 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPH3 Gene

Human Gene Mutation Database (HGMD)
HNRNPH3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPH3 Gene

Disorders for HNRNPH3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNRNPH3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
lymphatic system cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HNRNPH3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HNRNPH3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPH3 Gene

Publications for HNRNPH3 Gene

  1. Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest. (PMID: 8999868) Mahé D … Fuchs JP (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. The hnRNP 2H9 gene, which is involved in the splicing reaction, is a multiply spliced gene. (PMID: 10858537) Honoré B (Biochimica et biophysica acta 2000) 3 4 22 58
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58

Products for HNRNPH3 Gene

Sources for HNRNPH3 Gene

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