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HNRNPH3 Gene

protein-coding   GIFtS: 55
GCID: GC10P070090

Heterogeneous Nuclear Ribonucleoprotein H3 (2H9)


(Previous symbol: HNRPH3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Heterogeneous Nuclear Ribonucleoprotein H3 (2H9)1 2     HnRNP H32 3
HNRPH31 2 3 5     2H92 5
Heterogeneous Nuclear Ribonucleoprotein 2H92 3     Heterogeneous Nuclear Ribonucleoprotein H32
HnRNP 2H92 3     

External Ids:    HGNC: 50431   Entrez Gene: 31892   Ensembl: ENSG000000967467   OMIM: 6023245   UniProtKB: P319423   
ORGUL members:         

Export aliases for HNRNPH3 gene to outside databases

Previous GC identifers: GC10P069762 GC10P064093


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPH3 Gene:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are
associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA
metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the
nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded
by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the
nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced
splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants
have been noted for this gene, however, not all are fully characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for HNRNPH3 Gene:
HNRNPH3 (heterogeneous nuclear ribonucleoprotein H3 (2H9)) is a protein-coding gene. Diseases associated with HNRNPH3 include reticulosarcoma, and malignant histiocytosis. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBM12B.

UniProtKB/Swiss-Prot: HNRH3_HUMAN, P31942
Function: Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to
their great structural variations the different isoforms may possess different functions in the splicing reaction

Gene Wiki entry for HNRNPH3 (HNRPH3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPH3 gene promoter:
         Pbx1a   AML1a   Pax-2   Evi-1   NF-AT   MZF-1   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRNPH3 promoter sequence
   Search Chromatin IP Primers for HNRNPH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q22

HNRNPH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPH3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P070090:  view genomic region     (about GC identifiers)

Start:
70,090,931 bp from pter      End:
70,102,953 bp from pter
Size:
12,023 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HNRH3_HUMAN, P31942 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein H3  
Size: 346 amino acids; 36926 Da
Secondary accessions: A8K682 B3KRE1 Q9BSX1 Q9NP53 Q9NP96 Q9NPA7 Q9NPI4 Q9UFU4 Q9Y4J5
Alternative splicing: 6 isoforms:  P31942-1   P31942-2   P31942-3   P31942-4   P31942-5   P31942-6   

Explore the universe of human proteins at neXtProt for HNRNPH3: NX_P31942

Explore proteomics data for HNRNPH3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys67
  • Modification sites at PhosphoSitePlus

  • See HNRNPH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_036339.1  NP_067676.2  

    ENSEMBL proteins: 
     ENSP00000265866   ENSP00000346726   ENSP00000409869  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P31942

    ProtoNet protein and cluster: P31942

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: HNRH3_HUMAN, P31942
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    HNRNPH3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRH3_HUMAN, P31942
    Function: Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to
    their great structural variations the different isoforms may possess different functions in the splicing reaction

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding NAS10858537
    GO:0044822poly(A) RNA binding IDA--
         
    HNRNPH3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HNRNPH3:
     Increased G1 DNA content  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HNRNPH3
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    miRNA
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    miRTarBase miRNAs that target HNRNPH3:
    hsa-mir-15b-5p (MIRT046477), hsa-mir-769-3p (MIRT039115)

    Block miRNA regulation of human, mouse, rat HNRNPH3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPH3 (see all 17):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-142-5p hsa-miR-411 hsa-miR-340 hsa-miR-548l hsa-miR-570 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPH3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPH3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HNRH3_HUMAN, P31942: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex TAS8999868
    GO:0005730NOT nucleolus IDA--
    GO:0019013viral nucleocapsid ----
    GO:0030529ribonucleoprotein complex ----

    HNRNPH3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPH3
    Interactions:

        Search GeneGlobe Interaction Network for HNRNPH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPH3 (P319422, 3 ENSP000002658664) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS4XP627012, 3, ENSP000003627444MINT-63658 I2D: score=4 STRING: ENSP00000362744
    ZMYM2Q9UBW72, 3, ENSP000003723224MINT-62318 I2D: score=3 STRING: ENSP00000372322
    C14orf1Q9UKR52, 3MINT-63665 I2D: score=5 
    CRMP1Q141942, 3MINT-63659 I2D: score=5 
    EEF1GP266412, 3MINT-63657 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome NAS10858537
    GO:0006396RNA processing TAS8999868
    GO:0008380RNA splicing TAS8999868
    GO:0030855epithelial cell differentiation IEP--

    HNRNPH3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPH3 (HNRH3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HNRNPH3 gene (2 alternative transcripts): 
    NM_012207.2  NM_021644.3  

    Unigene Cluster for HNRNPH3:

    Heterogeneous nuclear ribonucleoprotein H3 (2H9)
    Hs.643472  [show with all ESTs]
    Unigene Representative Sequence: NM_012207
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469172(uc009xpu.3) ENST00000461310 ENST00000265866(uc001jnw.4 uc001jnx.4 uc010qiv.2)
    ENST00000480987 ENST00000486854 ENST00000467249 ENST00000354695 ENST00000481819
    ENST00000491200(uc001jny.4) ENST00000490442 ENST00000478698 ENST00000441000

    miRNA
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    Block miRNA regulation of human, mouse, rat HNRNPH3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPH3 (see all 17):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-142-5p hsa-miR-411 hsa-miR-340 hsa-miR-548l hsa-miR-570 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPH3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HNRNPH3
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HNRNPH3 (NM_021644)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPH3
    Primer
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    OriGene qPCR primer pairs and template standards for HNRNPH3
    OriGene qSTAR qPCR primer pairs in human, mouse for HNRNPH3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HNRNPH3
      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPH3
      QuantiFast Probe-based Assays in human, mouse, rat HNRNPH3

    Additional mRNA sequence: 

    AF052131.1 AF132361.1 AF132362.1 AK223441.1 AK291547.1 AK295316.1 BC004511.2 BC039824.1 

    Selected DOTS entries (see all 40):

    DT.97814563  DT.448460  DT.97780489  DT.102836965  DT.95267874  DT.91755504  DT.100044954  DT.100655854 
    DT.95267871  DT.100674048  DT.100044957  DT.100044959  DT.100858854  DT.121257648  DT.100674045  DT.95267904 
    DT.100674046  DT.121257676  DT.100809833  DT.100674043  DT.91696639  DT.95233774  DT.97779866  DT.95191783 

    Selected AceView cDNA sequences (see all 395):

    BM836708 AF132364 BQ882744 CB215748 BQ434442 CA407019 BM665198 BQ695021 
    BM803843 BG574151 AF132362 C03134 N79282 BQ950707 NM_021644 BC039824 
    CA417933 BQ223146 BU742127 BU541342 AI192388 AF132363 CD677991 BQ691243 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPH3 (see all 23)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ·
    SP1:                                                        -     -     -           -     -     -           -                 -     -                           
    SP2:                                                                                                        -                 -     -                           
    SP3:                                                                                                                                                            
    SP4:                                                              -     -           -     -     -     -     -                 -     -                           
    SP5:                                                        -     -     -           -     -     -           -                       -                           

    ExUns: 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
    SP1:  -                                                               
    SP2:  -                                                               
    SP3:  -                                                               
    SP4:  -                                                               
    SP5:  -                                                               


    ECgene alternative splicing isoforms for HNRNPH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGGAGGTG
    HNRNPH3 Expression
    About this image


    HNRNPH3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    HNRNPH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643472
        Custom PCR Arrays for HNRNPH3
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    QuantiTect SYBR Green Assays in human, mouse, rat HNRNPH3
    QuantiFast Probe-based Assays in human, mouse, rat HNRNPH3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HNRNPH3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnph31 , 5 heterogeneous nuclear ribonucleoprotein H31, 5 94.99(n)1
    99.42(a)1
      10 (32.52 cM)5
    4324671  NM_001079824.11  NP_001073293.11 
     630146645 
    chicken
    (Gallus gallus)
    Aves HNRNPH31 heterogeneous nuclear ribonucleoprotein H3 (2H9) 84.63(n)
    90.58(a)
      423686  NM_001012592.1  NP_001012610.1 
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPH36
    heterogeneous nuclear ribonucleoprotein H3 (2H9)
    91(a)
    1 ↔ 1
    GL343215.1(1485372-1492946)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.52362 Xenopus laevis transcribed sequence with moderate similarity more 80.12(n)    CD302920.1 
    zebrafish
    (Danio rerio)
    Actinopterygii HNRNPH36
    heterogeneous nuclear ribonucleoprotein H3 (2H9)
    52(a)
    1 ↔ 1
    13(23003728-23012629) ENSDARG00000039466


    ENSEMBL Gene Tree for HNRNPH3 (if available)
    TreeFam Gene Tree for HNRNPH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPH3 gene
    RBM12B2  ESRP12  HNRNPH22  GRSF12  ESRP22  HNRNPH12  HNRNPF2  RBM122  
    6 SIMAP similar genes for HNRNPH3 using alignment to 2 protein entries:     HNRH3_HUMAN (see all proteins):
    HNRNPH1    DKFZp686A15170    GRSF1    HNRNPH2    OK/SW-cl.23    HNRNPF

    HNRNPH3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HNRNPH3
    PGOHUM00000241869


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPH3 (see all 171)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880257911,2
    --70094726(+) GGTAGA/GGTGAG 2 -- int10--------
    rs1141734781,2
    F--70094772(+) ACCCTA/GTAAAA 2 -- int11Minor allele frequency- G:0.10WA 118
    rs1163386141,2
    C--70094778(+) TAAAAC/TAGATT 2 -- int10--------
    rs1420663051,2
    --70094812(+) TTTCCA/GCAATT 2 -- int10--------
    rs341334191,2
    C--70094868(+) AACAC-/TTTTTT 2 -- int10--------
    rs764854971,2
    --70094992(+) CTTTTC/TTTTTT 2 -- int10--------
    rs724088221,2
    C--70094993(+) TTTTC-/TTTTTTT 2 -- int10--------
    rs1925343041,2
    --70095088(+) CTTCAA/GTTTTT 2 -- int10--------
    rs782601981,2
    C--70095195(+) AAAAAA/TAAATA 2 -- int10--------
    rs2007546151,2
    --70095197(+) AAATA-/AATAAAAC 2 -- int10--------

    HapMap Linkage Disequilibrium report for HNRNPH3 (70090931 - 70102953 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HNRNPH3: --
    Human Gene Mutation Database (HGMD): HNRNPH3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPH3
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602324    OMIM disorders: --

    14 diseases for HNRNPH3:    
    About MalaCards
    reticulosarcoma    malignant histiocytosis    anterior uveitis    histiocytosis
    uveitis    neuroblastoma    hepatocellular carcinoma    alzheimer's disease
    hepatitis b    hiv-1    endotheliitis    melanoma
    thyroiditis    hepatitis


    HNRNPH3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HNRNPH3
    Human Genome Epidemiology (HuGE) Navigator: HNRNPH3 (1 document)

    Export disorders for HNRNPH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPH3 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with HNRNPH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest. (PubMed id 8999868)1, 2, 3, 9 Mahe D....Fuchs J.-P. (J. Biol. Chem. 1997)
    2. The hnRNP 2H9 gene, which is involved in the splicing reaction, is a multiply spliced gene. (PubMed id 10858537)1, 2, 9 Honore B. (Biochim. Biophys. Acta 2000)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A post-translational modification of nuclear proteins, N(G),N(G)- dimethyl-Arg, found in a natural HLA class I peptide ligand. (PubMed id 11152131)1, 2 Yague J.... Lopez de Castro J.A. (Protein Sci. 2000)
    9. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (Electrophoresis 1992)
    10. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3189 HGNC: 5043 AceView: HNRPH3 Ensembl:ENSG00000096746 euGenes: HUgn3189
    ECgene: HNRNPH3 H-InvDB: HNRNPH3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HNRNPH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPH3 gene:
    Search GeneIP for patents involving HNRNPH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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