Aliases for HNRNPH3 Gene
External Ids for HNRNPH3 Gene
Previous HGNC Symbols for HNRNPH3 Gene
Previous GeneCards Identifiers for HNRNPH3 Gene
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNRNPH3 Gene
HNRNPH3 (Heterogeneous Nuclear Ribonucleoprotein H3) is a Protein Coding gene. Diseases associated with HNRNPH3 include reticulosarcoma and lymphatic system cancer. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ESRP2.
UniProtKB/Swiss-Prot for HNRNPH3 Gene
Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.