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HNRNPH2 Gene

protein-coding   GIFtS: 51
GCID: GC0XP100663

Heterogeneous Nuclear Ribonucleoprotein H2 (H')


(Previous symbol: HNRPH2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein H2 (H')1 2     HNRPH'2
HNRPH21 2 3 5     Heterogeneous Nuclear Ribonucleoprotein H-Prime2
FTP-32 3     Heterogeneous Nuclear Ribonucleoprotein H22
FTP32 3     hnRNPH'2
HnRNP H'2 3     Heterogeneous Nuclear Ribonucleoprotein H'3
HnRNP H22 3     

External Ids:    HGNC: 50421   Entrez Gene: 31882   Ensembl: ENSG000001269457   OMIM: 3006105   UniProtKB: P557953   

Export aliases for HNRNPH2 gene to outside databases

Previous GC identifers: GC0XP100549 GC0XP100533 GC0XP090469


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPH2 Gene:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are
associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA
metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the
nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded
by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member
HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype.
Alternative splicing results in multiple transcript variants encoding the same protein. Read-through
transcription between this locus and the ribosomal protein L36a gene has been observed. (provided by RefSeq, Jan
2011)

GeneCards Summary for HNRNPH2 Gene:
HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2 (H')) is a protein-coding gene. Diseases associated with HNRNPH2 include agammaglobulinemia, and down syndrome. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBM12B.

UniProtKB/Swiss-Prot: HNRH2_HUMAN, P55795
Function: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which
provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable
mRNAs in the cytoplasm. Binds poly(RG)

Gene Wiki entry for HNRNPH2 (HNRPH2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPH2 gene promoter:
         HOXA9B   HOXA9   C/EBPbeta   p53   GATA-2   CREB   IRF-2   deltaCREB   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRNPH2 promoter sequence
   Search Chromatin IP Primers for HNRNPH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22

HNRNPH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPH2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP100663:  view genomic region     (about GC identifiers)

Start:
100,663,121 bp from pter      End:
100,669,128 bp from pter
Size:
6,008 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HNRH2_HUMAN, P55795 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein H2  
Size: 449 amino acids; 49264 Da
Subunit: Interacts with TXNL4/DIM1
2 PDB 3D structures from and Proteopedia for HNRNPH2:
1WEZ (3D)        1WG5 (3D)    
Secondary accessions: A1L400 Q9HHA7

Explore the universe of human proteins at neXtProt for HNRNPH2: NX_P55795

Explore proteomics data for HNRNPH2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35, Lys98, Lys167, Lys185, Lys200
  • Modification sites at PhosphoSitePlus

  • See HNRNPH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001027565.1  NP_062543.1  

    ENSEMBL proteins: 
     ENSP00000361927  
    Reactome Protein details: P55795

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012996 Znf_CHHC
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P55795

    ProtoNet protein and cluster: P55795

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB012996 Zinc finger


    UniProtKB/Swiss-Prot: HNRH2_HUMAN, P55795
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    HNRNPH2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRH2_HUMAN, P55795
    Function: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which
    provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable
    mRNAs in the cytoplasm. Binds poly(RG)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS7499401
    GO:0044822poly(A) RNA binding IDA--
         
    HNRNPH2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HNRNPH2
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    miRNA
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    miRTarBase miRNAs that target HNRNPH2:
    hsa-mir-484 (MIRT041915), hsa-mir-324-5p (MIRT043033)

    Block miRNA regulation of human, mouse, rat HNRNPH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPH2 (see all 28):
    hsa-miR-495 hsa-miR-4307 hsa-miR-4328 hsa-miR-300 hsa-miR-429 hsa-miR-485-3p hsa-miR-624 hsa-miR-513c
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPH2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HNRH2_HUMAN, P55795: Nucleus, nucleoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS7499401
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0015629actin cytoskeleton ----
    GO:0030529ribonucleoprotein complex IDA18809582

    HNRNPH2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPH2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HNRNPH2
        mRNA processing


    2 Reactome Pathways for HNRNPH2
        mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA



    HNRNPH2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPH2
    Interactions:

        Search GeneGlobe Interaction Network for HNRNPH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPH2 (P557952, 3 ENSP000003619274) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3296856 I2D: score=1 STRING: ENSP00000309503
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    GPN1Q9HCN43, ENSP000002647184I2D: score=1 STRING: ENSP00000264718
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    TOB1P506163, ENSP000002689574I2D: score=1 STRING: ENSP00000268957
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    HNRNPH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPH2 (HNRH2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HNRNPH2 gene (2 alternative transcripts): 
    NM_001032393.2  NM_019597.4  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000316594(uc022cag.1 uc022cah.1 uc004ehm.3 uc004ehn.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat HNRNPH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPH2 (see all 28):
    hsa-miR-495 hsa-miR-4307 hsa-miR-4328 hsa-miR-300 hsa-miR-429 hsa-miR-485-3p hsa-miR-624 hsa-miR-513c
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPH2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): HNRNPH2 (NM_019597)
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      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPH2
      QuantiFast Probe-based Assays in human, mouse, rat HNRNPH2

    Selected AceView cDNA sequences (see all 398):

    AI559641 BP338256 BM352153 AI174940 BP341852 CD677333 AW873648 BM699715 
    AI799921 BF223016 BQ772009 AA504969 BU659885 BP358061 BU788010 BE891421 
    AA297291 BM836238 CK826284 BG528737 CB134552 AI168039 AI682801 H08425 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPH2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c
    SP1:                                                
    SP2:                                                
    SP3:                    -                           
    SP4:                                                


    ECgene alternative splicing isoforms for HNRNPH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPH2 expression in normal human tissues (normalized intensities)      HNRNPH2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HNRNPH2 Expression
    About this image


    HNRNPH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    HNRNPH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPH2 Protein Expression

    UniProtKB/Swiss-Prot: HNRH2_HUMAN, P55795
    Tissue specificity: Expressed ubiquitously

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HNRNPH2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnph21 , 5 heterogeneous nuclear ribonucleoprotein H21, 5 93.69(n)1
    99.11(a)1
      X (56.20 cM)5
    562581  NM_019868.31  NP_063921.11 
     1346011795 
    chicken
    (Gallus gallus)
    Aves HNRNPH16
    Gallus gallus heterogeneous nuclear ribonucleoprot...
    73(a)
    1 → many
    13(12896978-12911863)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    83(a)
    1 → many
    2(140417161-140425189)
    zebrafish
    (Danio rerio)
    Actinopterygii hnrnph16
    hnrnph1l6
    heterogeneous nuclear ribonucleoprotein H1, like
    78(a)
    77(a)
    many ↔ many
    many ↔ many
    14(6957524-6980892) ENSDARG00000040881
    21(28913671-28925825) ENSDARG00000005551


    ENSEMBL Gene Tree for HNRNPH2 (if available)
    TreeFam Gene Tree for HNRNPH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPH2 gene
    RBM12B2  HNRNPH32  ESRP12  GRSF12  ESRP22  HNRNPH12  HNRNPF2  RBM122  
    5 SIMAP similar genes for HNRNPH2 using alignment to 1 protein entry:     HNRH2_HUMAN:
    DKFZp686A15170    HNRNPH1    HNRNPF    HNRNPH3    GRSF1

    HNRNPH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    7 SNPs for HNRNPH2    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453111181,2
    F--100635043(+) AGATAT/CGTGGA 4 /Y syn11Minor allele frequency- C:0.00NA 4542
    rs31902551,2
    C--100635080(+) CAAGTG/TGGGGT 4 G W mis12Minor allele frequency- T:0.00MN NA 186
    rs1997731771,2
    --100635146(+) GTGGCA/GCTTAT 4 T A mis10--------
    rs1476633581,2
    C--100635163(+) CAAATG/CATGGG 4 /I /M mis11Minor allele frequency- C:0.00NA 4550
    rs3728235861,2
    ----100635193(+) CAGTCC/TAGTTA 4 S syn10--------
    rs3747303211,2
    ----100634959(+) GTTACC/TGGTGA 4 T syn10--------
    rs3690568491,2
    ----100635143(+) GTGGTA/GGCGCT 4 S G mis10--------

    HapMap Linkage Disequilibrium report for HNRNPH2 (100663121 - 100669128 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HNRNPH2: --
    Locus Specific Mutation Databases (LSDB): HNRNPH2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPH2
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300610    OMIM disorders: --

    9 diseases for HNRNPH2:    About MalaCards
    agammaglobulinemia    down syndrome    tonsillitis    hiv-1
    neuroblastoma    cerebritis    thyroiditis    endotheliitis
    prostatitis


    HNRNPH2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HNRNPH2
    Human Genome Epidemiology (HuGE) Navigator: HNRNPH2 (3 documents)

    Export disorders for HNRNPH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPH2 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with HNRNPH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes. (PubMed id 7499401)1, 2, 3 Honore B.... Celis J.E. (J. Biol. Chem. 1995)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. Evidence that Dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for Dim1 interactions with hnRNP F and Npw38/PQBP-1. (PubMed id 11054566)1, 2 Zhang Y.-Z....Golemis E.A. (Gene 2000)
    5. Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. (PubMed id 9110171)1, 2 Oeltjen J.C....Belmont J.W. (Genome Res. 1997)
    6. Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22. (PubMed id 7959728)1, 2 Vorechovsky I.... Ochs H.D. (Genomics 1994)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    8. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    9. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3188 HGNC: 5042 AceView: HNRPH2 Ensembl:ENSG00000126945 euGenes: HUgn3188
    ECgene: HNRNPH2 H-InvDB: HNRNPH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HNRNPH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPH2 gene:
    Search GeneIP for patents involving HNRNPH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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