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Aliases for HNRNPH2 Gene

Aliases for HNRNPH2 Gene

  • Heterogeneous Nuclear Ribonucleoprotein H2 (H') 2
  • HNRPH2 3 4 6
  • Heterogeneous Nuclear Ribonucleoprotein H2 (H) 2 3
  • HnRNP H2 3 4
  • HnRNP H 3 4
  • FTP-3 3 4
  • FTP3 3 4
  • Heterogeneous Nuclear Ribonucleoprotein H-Prime 3
  • Heterogeneous Nuclear Ribonucleoprotein H2 3
  • Heterogeneous Nuclear Ribonucleoprotein H 4
  • HnRNPH 3
  • HNRPH 3

External Ids for HNRNPH2 Gene

Previous HGNC Symbols for HNRNPH2 Gene

  • HNRPH2

Previous GeneCards Identifiers for HNRNPH2 Gene

  • GC0XP100549
  • GC0XP100533
  • GC0XP100663
  • GC0XP090469

Summaries for HNRNPH2 Gene

Entrez Gene Summary for HNRNPH2 Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. [provided by RefSeq, Jan 2011]

GeneCards Summary for HNRNPH2 Gene

HNRNPH2 (Heterogeneous Nuclear Ribonucleoprotein H2 (H')) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is ESRP2.

UniProtKB/Swiss-Prot for HNRNPH2 Gene

  • This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG)

Gene Wiki entry for HNRNPH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPH2 Gene

Genomics for HNRNPH2 Gene

Regulatory Elements for HNRNPH2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HNRNPH2 Gene

Start:
101,408,133 bp from pter
End:
101,414,140 bp from pter
Size:
6,008 bases
Orientation:
Plus strand

Genomic View for HNRNPH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPH2 Gene

Proteins for HNRNPH2 Gene

  • Protein details for HNRNPH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55795-HNRH2_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein H2
    Protein Accession:
    P55795
    Secondary Accessions:
    • A1L400
    • Q9HHA7

    Protein attributes for HNRNPH2 Gene

    Size:
    449 amino acids
    Molecular mass:
    49264 Da
    Quaternary structure:
    • Interacts with TXNL4/DIM1.

    Three dimensional structures from OCA and Proteopedia for HNRNPH2 Gene

neXtProt entry for HNRNPH2 Gene

Proteomics data for HNRNPH2 Gene at MOPED

Post-translational modifications for HNRNPH2 Gene

  • Ubiquitination at Lys35, Lys98, Lys167, Lys185, and Lys200
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPH2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HNRNPH2 Gene

Domains for HNRNPH2 Gene

Gene Families for HNRNPH2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for HNRNPH2 Gene

Graphical View of Domain Structure for InterPro Entry

P55795

UniProtKB/Swiss-Prot:

HNRH2_HUMAN :
  • P55795
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPH2: view

Function for HNRNPH2 Gene

Molecular function for HNRNPH2 Gene

UniProtKB/Swiss-Prot Function: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG)

Gene Ontology (GO) - Molecular Function for HNRNPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 7499401
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HNRNPH2: view

Animal Model Products

CRISPR Products

miRNA for HNRNPH2 Gene

miRTarBase miRNAs that target HNRNPH2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPH2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPH2 Gene

Localization for HNRNPH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPH2 Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPH2 Gene COMPARTMENTS Subcellular localization image for HNRNPH2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for HNRNPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7499401
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0030529 ribonucleoprotein complex IDA 18809582
genes like me logo Genes that share ontologies with HNRNPH2: view

Pathways for HNRNPH2 Gene

genes like me logo Genes that share pathways with HNRNPH2: view

Pathways by source for HNRNPH2 Gene

1 BioSystems pathway for HNRNPH2 Gene

Interacting Proteins for HNRNPH2 Gene

Gene Ontology (GO) - Biological Process for HNRNPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with HNRNPH2: view

Transcripts for HNRNPH2 Gene

mRNA/cDNA for HNRNPH2 Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPH2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPH2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c
SP1:
SP2:
SP3: -
SP4:

Relevant External Links for HNRNPH2 Gene

GeneLoc Exon Structure for
HNRNPH2
ECgene alternative splicing isoforms for
HNRNPH2

Expression for HNRNPH2 Gene

mRNA expression in normal human tissues for HNRNPH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPH2 Gene

mRNA Expression by UniProt/SwissProt for HNRNPH2 Gene

P55795-HNRH2_HUMAN
Tissue specificity: Expressed ubiquitously
genes like me logo Genes that share expressions with HNRNPH2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HNRNPH2 Gene

Orthologs for HNRNPH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPH2 35
  • 100 (n)
  • 100 (a)
HNRNPH2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HNRNPH2 35
  • 95.1 (n)
  • 99.33 (a)
HNRPH2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPH2 35
  • 95.55 (n)
  • 99.55 (a)
HNRNPH2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnph2 35
  • 93.69 (n)
  • 99.11 (a)
Hnrnph2 16
Hnrnph2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPH2 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnph2 35
  • 93.39 (n)
  • 98.89 (a)
chicken
(Gallus gallus)
Aves HNRNPH1 36
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hnrnph1 36
  • 78 (a)
ManyToMany
hnrnph1l 36
  • 77 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for HNRNPH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPH2 Gene

ENSEMBL:
Gene Tree for HNRNPH2 (if available)
TreeFam:
Gene Tree for HNRNPH2 (if available)

Paralogs for HNRNPH2 Gene

Paralogs for HNRNPH2 Gene

Selected SIMAP similar genes for HNRNPH2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HNRNPH2: view

Variants for HNRNPH2 Gene

Relevant External Links for HNRNPH2 Gene

HapMap Linkage Disequilibrium report
HNRNPH2
Locus Specific Mutation Databases (LSDB)
HNRNPH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for HNRNPH2 Gene

Disorders for HNRNPH2 Gene

Relevant External Links for HNRNPH2

Genetic Association Database (GAD)
HNRNPH2
Human Genome Epidemiology (HuGE) Navigator
HNRNPH2
genes like me logo Genes that share disorders with HNRNPH2: view

No data available for UniProtKB/Swiss-Prot for HNRNPH2 Gene

Publications for HNRNPH2 Gene

  1. Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes. (PMID: 7499401) Honore B. … Celis J.E. (J. Biol. Chem. 1995) 2 3 4
  2. Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22. (PMID: 7959728) Vorechovsky I. … Ochs H.D. (Genomics 1994) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Evidence that Dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for Dim1 interactions with hnRNP F and Npw38/PQBP-1. (PMID: 11054566) Zhang Y.-Z. … Golemis E.A. (Gene 2000) 3 4
  5. Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. (PMID: 9110171) Oeltjen J.C. … Belmont J.W. (Genome Res. 1997) 3 4

Products for HNRNPH2 Gene

Sources for HNRNPH2 Gene

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