Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HNRNPH1 Gene

Aliases for HNRNPH1 Gene

  • Heterogeneous Nuclear Ribonucleoprotein H1 (H) 2 3
  • HNRPH1 3 4 6
  • HNRPH 3 4
  • Heterogeneous Nuclear Ribonucleoprotein H 3
  • HnRNP H 4
  • HnRNPH 3

External Ids for HNRNPH1 Gene

Previous Symbols for HNRNPH1 Gene

  • HNRPH1

Summaries for HNRNPH1 Gene

Entrez Gene Summary for HNRNPH1 Gene

  • This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]

GeneCards Summary for HNRNPH1 Gene

HNRNPH1 (Heterogeneous Nuclear Ribonucleoprotein H1 (H)) is a Protein Coding gene. Diseases associated with HNRNPH1 include precursor t-cell acute lymphoblastic leukemia and hereditary lymphedema. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and poly(U) RNA binding. An important paralog of this gene is ESRP2.

UniProtKB/Swiss-Prot for HNRNPH1 Gene

  • This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).

Gene Wiki entry for HNRNPH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPH1 Gene

Genomics for HNRNPH1 Gene

Genomic Location for HNRNPH1 Gene

Start:
179,614,178 bp from pter
End:
179,634,784 bp from pter
Size:
20,607 bases
Orientation:
Minus strand

Genomic View for HNRNPH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPH1 Gene

Regulatory Elements for HNRNPH1 Gene

Proteins for HNRNPH1 Gene

  • Protein details for HNRNPH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31943-HNRH1_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein H
    Protein Accession:
    P31943
    Secondary Accessions:
    • B3KW86
    • D3DWQ2
    • Q6IBM4

    Protein attributes for HNRNPH1 Gene

    Size:
    449 amino acids
    Molecular mass:
    49229 Da
    Quaternary structure:
    • Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with CUGBP1; the interaction is RNA-dependent. Interacts with MBNL1; the interaction in RNA-independent.

    Three dimensional structures from OCA and Proteopedia for HNRNPH1 Gene

neXtProt entry for HNRNPH1 Gene

Proteomics data for HNRNPH1 Gene at MOPED

Post-translational modifications for HNRNPH1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys14, Lys35, Lys87, Lys98, Lys167, Lys185, and Lys200

No data available for DME Specific Peptides for HNRNPH1 Gene

Domains for HNRNPH1 Gene

Gene Families for HNRNPH1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

UniProtKB/Swiss-Prot:

HNRH1_HUMAN
Domain:
  • Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA):
    • P31943
  • Contains 3 RRM (RNA recognition motif) domains.:
    • P31943
genes like me logo Genes that share domains with HNRNPH1: view

Function for HNRNPH1 Gene

Molecular function for HNRNPH1 Gene

UniProtKB/Swiss-Prot Function: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).
UniProtKB/Swiss-Prot Induction: Up-regulated in myotonic dystrophy pathophysiology (DM).

Gene Ontology (GO) - Molecular Function for HNRNPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IDA 16946708
GO:0005515 protein binding IPI 16946708
GO:0008266 poly(U) RNA binding TAS 7499401
genes like me logo Genes that share ontologies with HNRNPH1: view
genes like me logo Genes that share phenotypes with HNRNPH1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPH1 Gene

Localization for HNRNPH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPH1 Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPH1 Gene COMPARTMENTS Subcellular localization image for HNRNPH1 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4

Gene Ontology (GO) - Cellular Components for HNRNPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7499401
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with HNRNPH1: view

Pathways for HNRNPH1 Gene

genes like me logo Genes that share pathways with HNRNPH1: view

Pathways by source for HNRNPH1 Gene

1 BioSystems pathway for HNRNPH1 Gene

Gene Ontology (GO) - Biological Process for HNRNPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006396 RNA processing TAS 7499401
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
GO:0043484 regulation of RNA splicing IDA 16946708
genes like me logo Genes that share ontologies with HNRNPH1: view

Transcripts for HNRNPH1 Gene

Unigene Clusters for HNRNPH1 Gene

Heterogeneous nuclear ribonucleoprotein H1 (H):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPH1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a ·
SP1: - - - - -
SP2: - - - - - - - -
SP3:
SP4: - - - - - - - -
SP5:
SP6: - - - - -
SP7: - - -
SP8: - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - -
SP14:
SP15:
SP16:
SP17:
SP18: - - - - - - -
SP19: - - -
SP20:
SP21: - - - - -
SP22:
SP23: - - - - - - - -
SP24: - - - - - - - -
SP25: - -
SP26:
SP27:
SP28:

ExUns: 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18a ·
SP1: - - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8:
SP9:
SP10:
SP11: - - - - - - -
SP12:
SP13:
SP14: - - -
SP15: - -
SP16: - - - -
SP17:
SP18: - - -
SP19: - - - - - - -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27: -
SP28: - - -

Relevant External Links for HNRNPH1 Gene

GeneLoc Exon Structure for
HNRNPH1
ECgene alternative splicing isoforms for
HNRNPH1

Expression for HNRNPH1 Gene

mRNA expression in normal human tissues for HNRNPH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPH1 Gene

SOURCE GeneReport for Unigene cluster for HNRNPH1 Gene Hs.604001

mRNA Expression by UniProt/SwissProt for HNRNPH1 Gene

P31943-HNRH1_HUMAN
Tissue specificity: Expressed ubiquitously
genes like me logo Genes that share expressions with HNRNPH1: view

Orthologs for HNRNPH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPH1 36
  • 99.85 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia HNRNPH1 36
  • 97.48 (n)
  • 100 (a)
HNRNPH1 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPH1 36
  • 97.48 (n)
  • 100 (a)
HNRNPH1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnph1 36
  • 96.44 (n)
  • 99.78 (a)
Hnrnph1 16
Hnrnph1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 82 (a)
OneToMany
-- 37
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPH1 37
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPH1 36
  • 81.1 (n)
  • 87.35 (a)
HNRNPH1 37
  • 74 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 84 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.22668 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnph1 36
  • 75.89 (n)
  • 83.55 (a)
Str.17058 36
zebrafish
(Danio rerio)
Actinopterygii Dr.782 36
hnrnph1 37
  • 78 (a)
ManyToMany
hnrnph1l 36
  • 76.56 (n)
  • 87.32 (a)
hnrnph1l 37
  • 78 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea hrpf-2 36
  • 48.99 (n)
  • 38.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToMany
Species with no ortholog for HNRNPH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPH1 Gene

ENSEMBL:
Gene Tree for HNRNPH1 (if available)
TreeFam:
Gene Tree for HNRNPH1 (if available)

Paralogs for HNRNPH1 Gene

Paralogs for HNRNPH1 Gene

genes like me logo Genes that share paralogs with HNRNPH1: view

Variants for HNRNPH1 Gene

Sequence variations from dbSNP and Humsavar for HNRNPH1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs3615 -- 179,619,257(+) CAACC(A/G)TCCAT intron-variant
rs1058753 -- 179,614,277(-) AAATT(C/T)TGAGG utr-variant-3-prime
rs1136267 -- 179,623,187(-) CTCAG(G/T)TCTGG intron-variant
rs1802906 -- 179,614,370(-) CACGT(A/T)AGTTT utr-variant-3-prime
rs4078141 -- 179,624,537(+) CCGCT(A/G)CATCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HNRNPH1 Gene

Variant ID Type Subtype PubMed ID
nsv883270 CNV Loss 21882294
nsv7375 OTHER Inversion 18451855
nsv281 OTHER Inversion 15895083
nsv830560 CNV Loss 17160897
nsv883273 CNV Loss 21882294
nsv823357 CNV Gain 20364138

Relevant External Links for HNRNPH1 Gene

HapMap Linkage Disequilibrium report
HNRNPH1
Human Gene Mutation Database (HGMD)
HNRNPH1

Disorders for HNRNPH1 Gene

genes like me logo Genes that share disorders with HNRNPH1: view

No data available for UniProtKB/Swiss-Prot for HNRNPH1 Gene

Publications for HNRNPH1 Gene

  1. Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes. (PMID: 7499401) Honore B. … Celis J.E. (J. Biol. Chem. 1995) 2 3 4 23
  2. Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs. (PMID: 19244236) Wang E. … Cambi F. (J. Biol. Chem. 2009) 3 23
  3. The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization. (PMID: 7512260) Matunis M.J. … Dreyfuss G. (Nucleic Acids Res. 1994) 3 4
  4. Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. (PMID: 20145135) Rauch J. … Gires O. (Cancer Res. 2010) 3 23
  5. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PMID: 1286667) Rasmussen H.H. … Vandekerckhove J. (Electrophoresis 1992) 3 4

Products for HNRNPH1 Gene

Sources for HNRNPH1 Gene

Back to Top

Content