Aliases for HNRNPH1 Gene
Aliases for HNRNPH1 Gene
External Ids for HNRNPH1 Gene
- HGNC: 5041
- Entrez Gene: 3187
- Ensembl: ENSG00000169045
- OMIM: 601035
- UniProtKB: P31943
Previous HGNC Symbols for HNRNPH1 Gene
- HNRPH1
Previous GeneCards Identifiers for HNRNPH1 Gene
- GC05M178974
- GC05M179043
- GC05M173768
Summaries for HNRNPH1 Gene
-
This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]
GeneCards Summary for HNRNPH1 Gene
HNRNPH1 (Heterogeneous Nuclear Ribonucleoprotein H1) is a Protein Coding gene. Diseases associated with HNRNPH1 include Precursor T-Cell Acute Lymphoblastic Leukemia and Hereditary Lymphedema. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPH2.
UniProtKB/Swiss-Prot for HNRNPH1 Gene
-
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPH1 Gene
Genomics for HNRNPH1 Gene
Regulatory Elements for HNRNPH1 Gene
Enhancers for HNRNPH1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G179619 | 1.7 | Ensembl ENCODE dbSUPER | 7.9 | +12.5 | 12512 | 6.1 | MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZFP41 | LOC101928445 ZNF879 CLK4 RUFY1 MAML1 ENSG00000248367 ENSG00000253520 HNRNPH1 GC05M179481 ENSG00000273549 |
| GH05G179969 | 1.2 | FANTOM5 Ensembl ENCODE | 3.6 | -336.6 | -336570 | 2.8 | ZNF707 POLR2A NBN RELB ZNF18 | RNF130 MIR340 TBC1D9B MRNIP MAML1 SQSTM1 RUFY1 HNRNPH1 GC05M179952 PIR35962 |
| GH05G180069 | 1.7 | FANTOM5 ENCODE dbSUPER | 2.4 | -436.2 | -436196 | 3.6 | MLX CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 | ZFP62 RNF130 MAML1 CNOT6 LOC100996419 LOC105377763 SQSTM1 HNRNPH1 GC05M180018 |
| GH05G179635 | 0.5 | dbSUPER | 8 | +0.3 | 264 | 1.6 | PHF8 PRDM10 NR3C1 ZFX | HNRNPH1 ENSG00000253520 ENSG00000273549 |
| GH05G179637 | 0.5 | dbSUPER | 8 | +0.3 | 302 | 1.5 | PHF8 PRDM10 NR3C1 ZFX | HNRNPH1 ENSG00000253520 ENSG00000273549 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HNRNPH1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HNRNPH1 gene promoter:
Regulatory Element Products
Genomic Location for HNRNPH1 Gene
- Chromosome:
- 5
- Start:
- 179,614,178 bp from pter
- End:
- 179,634,784 bp from pter
- Size:
- 20,607 bases
- Orientation:
- Minus strand
Genomic View for HNRNPH1 Gene
Genes around HNRNPH1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.3 by Ensembl
- 5q35.3 by Entrez Gene
- 5q35.3 by HGNC
HNRNPH1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPH1 Gene
Proteins for HNRNPH1 Gene
-
Protein details for HNRNPH1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31943-HNRH1_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoprotein H
- Protein Accession:
- P31943
- B3KW86
- D3DWQ2
- Q6IBM4
Protein attributes for HNRNPH1 Gene
- Size:
- 449 amino acids
- Molecular mass:
- 49229 Da
- Quaternary structure:
-
- Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with CUGBP1; the interaction is RNA-dependent. Interacts with MBNL1; the interaction in RNA-independent.
Protein Expression for HNRNPH1 Gene
Post-translational modifications for HNRNPH1 Gene
Other Protein References for HNRNPH1 Gene
- ENSEMBL proteins:
-
- ENSP00000327539
- ENSP00000377082
- ENSP00000397797
- ENSP00000420850
- ENSP00000421695
- ENSP00000422955
- ENSP00000423140
- ENSP00000424087
- ENSP00000425343
- ENSP00000425732
- ENSP00000425851
- ENSP00000426275
- ENSP00000426518
- ENSP00000426726
- ENSP00000427351
- ENSP00000427388
- ENSP00000427408
- ENSP00000427845
- ENSP00000427986
- ENSP00000428620
- ENSP00000429179
- ENSP00000429270
- ENSP00000429481
- ENSP00000429661
- ENSP00000429673
- ENSP00000430156
- ENSP00000430445
- ENSP00000430970
- ENSP00000486889
- ENSP00000349168
- REFSEQ proteins:
-
- NP_001244222.1
- NP_005511.1
- XP_005265952.1
- XP_005265953.1
- XP_005265958.1
- XP_005265959.1
- XP_006714925.1
- XP_006714926.1
- XP_011532844.1
- XP_011532846.1
- XP_011532847.1
- XP_011532848.1
- XP_011532849.1
- XP_016864903.1
- XP_016864904.1
- XP_016864905.1
- XP_016864906.1
- XP_016864907.1
- XP_016864908.1
- XP_016864909.1
- XP_016864910.1
- XP_016864911.1
- XP_016864912.1
- XP_016864913.1
- XP_016864914.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HNRNPH1
- Novus Biologicals Antibodies for HNRNPH1
- Invitrogen Antibodies for HNRNPH1
- antibodies-online Antibodies for HNRNPH1: See all 75
- GeneTex HNRNPH1 antibody for HNRNPH1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPH1
Protein Products
-
OriGene Purified Proteins for HNRNPH1
- Search Origene for MassSpec and Protein Over-expression Lysates for HNRNPH1
- Origene Custom Protein Services for HNRNPH1
- Novus Biologicals lysates for HNRNPH1
- antibodies-online Proteins for HNRNPH1: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HNRNPH1
Assay Products
- antibodies-online Kits for HNRNPH1: See all 21
No data available for DME Specific Peptides for HNRNPH1 Gene
Domains & Families for HNRNPH1 Gene
Gene Families for HNRNPH1 Gene
Protein Domains for HNRNPH1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPH1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31943UniProtKB/Swiss-Prot:
HNRH1_HUMAN :- Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA).
- Domain:
-
- Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA).
Function for HNRNPH1 Gene
Molecular function for HNRNPH1 Gene
- UniProtKB/Swiss-Prot Function:
- This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in myotonic dystrophy pathophysiology (DM).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IDA,IEA | 16946708 |
| GO:0005515 | protein binding | IPI | 9111328 |
| GO:0008266 | poly(U) RNA binding | TAS | 7499401 |
Phenotypes for HNRNPH1 Gene
- MGI mutant phenotypes for HNRNPH1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HNRNPH1:
Animal Models for HNRNPH1 Gene
- MGI Knock Outs for HNRNPH1:
-
- Hnrnph1 tm1b(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPH1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPH1 gene
- Search ViGene Biosciences for HNRNPH1
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPH1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPH1
- GenScript: Design CRISPR guide RNA sequences for HNRNPH1
miRNA for HNRNPH1 Gene
- miRTarBase miRNAs that target HNRNPH1
miRNA Products
- Search ViGene Biosciences for HNRNPH1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HNRNPH1
- Browse OriGene Inhibitory RNA Products For HNRNPH1
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPH1 gene
Clone Products
-
OriGene ORF clones in human for HNRNPH1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HNRNPH1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HNRNPH1
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for HNRNPH1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPH1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPH1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HNRNPH1 Gene
Localization for HNRNPH1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPH1 Gene
- Nucleus, nucleoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,TAS | 24910439 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005681 | spliceosomal complex | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0016020 | membrane | IDA | 19946888 |
Pathways & Interactions for HNRNPH1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.41
|
| 2 | Signaling by FGFR2 | ||
| 3 | mRNA Capping | ||
| 4 | Gene Expression |
.48
|
|
| 5 | Signaling by GPCR | ||
Pathways by source for HNRNPH1 Gene
2 BioSystems pathways for HNRNPH1 Gene
8 Reactome pathways for HNRNPH1 Gene
Interacting Proteins for HNRNPH1 Gene
Selected Interacting proteins:
P31943-HNRH1_HUMAN
ENSP00000349168
for HNRNPH1 Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006396 | RNA processing | TAS | 7499401 |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | IEA | -- |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | TAS | -- |
No data available for SIGNOR curated interactions for HNRNPH1 Gene
Transcripts for HNRNPH1 Gene
mRNA/cDNA for HNRNPH1 Gene
- (25) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (775) Selected AceView cDNA sequences:
- (50) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HNRNPH1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPH1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPH1
- GenScript: Design CRISPR guide RNA sequences for HNRNPH1
miRNA Products
- Search ViGene Biosciences for HNRNPH1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HNRNPH1
- Browse OriGene Inhibitory RNA Products For HNRNPH1
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPH1 gene
Clone Products
-
OriGene ORF clones in human for HNRNPH1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HNRNPH1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HNRNPH1
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP25: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP26: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP27: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP28: |
| ExUns: | 9b | · | 9c | · | 9d | · | 9e | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP25: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP26: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP27: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP28: | - | - | - |
Expression for HNRNPH1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPH1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HNRNPH1 Gene:
HNRNPH1SOURCE GeneReport for Unigene cluster for HNRNPH1 Gene:
Hs.604001mRNA Expression by UniProt/SwissProt for HNRNPH1 Gene:
P31943-HNRH1_HUMAN
Tissue specificity:
Expressed ubiquitously.
Evidence on tissue expression from TISSUES for HNRNPH1 Gene
- Nervous system(5)
- Liver(4.7)
- Skin(4.6)
- Muscle(4.4)
- Lung(4)
- Intestine(3.6)
- Kidney(3.5)
- Bone marrow(2.7)
- Lymph node(2.6)
- Spleen(2.6)
- Blood(2.5)
- Eye(2.5)
- Stomach(2.4)
- Adrenal gland(2.3)
- Gall bladder(2.3)
- Thyroid gland(2.3)
- Heart(2.1)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for HNRNPH1
-
OriGene qPCR primer pairs and template standards for HNRNPH1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPH1 Gene
Orthologs for HNRNPH1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HNRNPH1 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HNRNPH1 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HNRNPH1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HNRNPH1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hnrnph1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | HNRNPH1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hnrnph1 34 |
|
||
| Str.17058 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.22668 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hnrnph1 35 |
|
ManyToMany | |
| hnrnph1l 34 35 |
|
||||
| Dr.782 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | hrpf-2 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HNRNPH1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HNRNPH1 Gene
(8) SIMAP similar genes for HNRNPH1 Gene using alignment to 27 proteins:
- HNRH1_HUMAN
- D6R9D3_HUMAN
- D6R9T0_HUMAN
- D6RAM1_HUMAN
- D6RBM0_HUMAN
- D6RDL0_HUMAN
- D6RDU3_HUMAN
- D6RF17_HUMAN
- D6RFM3_HUMAN
- D6RIH9_HUMAN
- D6RIT2_HUMAN
- D6RIU0_HUMAN
- D6RJ04_HUMAN
- E5RGH4_HUMAN
- E5RGV0_HUMAN
- E5RJ94_HUMAN
- E7EN40_HUMAN
- E7EQJ0_HUMAN
- E9PCY7_HUMAN
- F5GZT4_HUMAN
- G8JLB6_HUMAN
- H0YAQ2_HUMAN
- H0YB39_HUMAN
- H0YBD7_HUMAN
- H0YBG7_HUMAN
- H0YBK1_HUMAN
- H0YBW2_HUMAN
Pseudogenes.org Pseudogenes for HNRNPH1 Gene
Variants for HNRNPH1 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000091706 | -- | 179,623,847(+) | CAGCA(C/G)CCCCA | intron-variant, upstream-variant-2KB | |
| rs1000144967 | -- | 179,613,924(+) | CTGGC(A/G)CCTCC | downstream-variant-500B | |
| rs1000209177 | -- | 179,614,992(+) | GGAGT(A/G)ATATC | intron-variant | |
| rs1000241502 | -- | 179,624,112(+) | CTGGC(C/T)GACCT | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000260148 | -- | 179,619,676(+) | AAGAA(C/T)ACATA | intron-variant, utr-variant-5-prime |
Residual Variation Intolerance Score:
31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.63;
13.59% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HNRNPH1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPH1 Gene
Disorders for HNRNPH1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| precursor t-cell acute lymphoblastic leukemia |
|
|
| hereditary lymphedema |
|
|
| lymphedema |
|
|
| congenital lymphedema |
|
|
| congenital myasthenic syndrome |
|
|
Search HNRNPH1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HNRNPH1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HNRNPH1
No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPH1 Gene
Publications for HNRNPH1 Gene
- Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes. (PMID: 7499401) Honore B. … Celis J.E. (J. Biol. Chem. 1995) 2 3 4 22 64
- Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. (PMID: 20145135) Rauch J. … Gires O. (Cancer Res. 2010) 3 22 64
- Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs. (PMID: 19244236) Wang E. … Cambi F. (J. Biol. Chem. 2009) 3 22 64
- Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Joeson L. … Nielsen F.C. (Mol. Cell. Proteomics 2007) 3 4 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
Products for HNRNPH1 Gene
- Browse R&D Systems for Antibodies
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for HNRNPH1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HNRNPH1
- Search Origene for MassSpec and Protein Over-expression Lysates for HNRNPH1
- Origene Custom Protein Services for HNRNPH1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HNRNPH1
- Browse OriGene Inhibitory RNA Products For HNRNPH1
- OriGene qPCR primer pairs and template standards for HNRNPH1
- OriGene qPCR primer pairs for HNRNPH1
- OriGene CRISPR knockouts for HNRNPH1
- OriGene ORF clones in human for HNRNPH1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HNRNPH1
- GenScript: Next-day shipping cDNA ORF clone for HNRNPH1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HNRNPH1
- GenScript Custom Assay Services for HNRNPH1
- GenScript Custom overexpressing Cell Line Services for HNRNPH1
- GenScript: Design CRISPR guide RNA sequences for HNRNPH1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HNRNPH1
- Sino Biological Human cDNA Clone for HNRNPH1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HNRNPH1
- Novus Biologicals lysates for HNRNPH1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Addgene plasmids for HNRNPH1
- antibodies-online Antibodies for HNRNPH1: See all 75
- antibodies-online Kits for HNRNPH1: See all 21
- antibodies-online Proteins for HNRNPH1: See all 5
- Search antibodies-online for peptides
- GeneTex HNRNPH1 antibody for HNRNPH1
- Search GeneTex for Proteins for HNRNPH1
- ViGene Biosciences adenoviral particle packaged cDNA for HNRNPH1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HNRNPH1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HNRNPH1 gene
- Search ViGene Biosciences for HNRNPH1
- Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPH1
- Search Santa Cruz Biotechnology (SCBT) for HNRNPH1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPH1
- Cyagen custom Knockout/knockin (KOKI) mouse models for HNRNPH1
- VectorBuilder custom plasmid, inducible vectors for HNRNPH1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HNRNPH1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HNRNPH1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (115) ProteomicsDB
- (116) SCBT
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- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer