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Aliases for HNRNPF Gene

Aliases for HNRNPF Gene

  • Heterogeneous Nuclear Ribonucleoprotein F 2 3
  • HNRPF 3 4 6
  • Nucleolin-Like Protein Mcs94-1 3 4
  • HnRNP F Protein 3
  • OK/SW-Cl.23 3
  • Mcs94-1 3
  • HnRNP F 4

External Ids for HNRNPF Gene

Previous Symbols for HNRNPF Gene

  • HNRPF

Summaries for HNRNPF Gene

Entrez Gene Summary for HNRNPF Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPF Gene

HNRNPF (Heterogeneous Nuclear Ribonucleoprotein F) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and single-stranded RNA binding. An important paralog of this gene is ESRP2.

UniProtKB/Swiss-Prot for HNRNPF Gene

  • Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.

Gene Wiki entry for HNRNPF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPF Gene

Genomics for HNRNPF Gene

Genomic Location for HNRNPF Gene

Start:
43,385,617 bp from pter
End:
43,409,248 bp from pter
Size:
23,632 bases
Orientation:
Minus strand

Genomic View for HNRNPF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPF Gene

Regulatory Elements for HNRNPF Gene

Proteins for HNRNPF Gene

  • Protein details for HNRNPF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52597-HNRPF_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein F
    Protein Accession:
    P52597
    Secondary Accessions:
    • B3KM84
    • Q5T0N2
    • Q96AU2

    Protein attributes for HNRNPF Gene

    Size:
    415 amino acids
    Molecular mass:
    45672 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1.

    Three dimensional structures from OCA and Proteopedia for HNRNPF Gene

neXtProt entry for HNRNPF Gene

Proteomics data for HNRNPF Gene at MOPED

Post-translational modifications for HNRNPF Gene

  • Sumoylated.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys14, Lys87, Lys98, Lys167, Lys185, Lys200, Lys224, and Lys299

Other Protein References for HNRNPF Gene

No data available for DME Specific Peptides for HNRNPF Gene

Domains for HNRNPF Gene

Gene Families for HNRNPF Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

UniProtKB/Swiss-Prot:

HNRPF_HUMAN
Domain:
  • The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA:
    • P52597
  • Contains 3 RRM (RNA recognition motif) domains.:
    • P52597
genes like me logo Genes that share domains with HNRNPF: view

Function for HNRNPF Gene

Molecular function for HNRNPF Gene

UniProtKB/Swiss-Prot Function: Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.

Gene Ontology (GO) - Molecular Function for HNRNPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 7499401
GO:0003727 single-stranded RNA binding IDA 20526337
GO:0005515 protein binding IPI 17932509
genes like me logo Genes that share ontologies with HNRNPF: view

Phenotypes for HNRNPF Gene

GenomeRNAi human phenotypes for HNRNPF:
genes like me logo Genes that share phenotypes with HNRNPF: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPF Gene

Localization for HNRNPF Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPF Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPF Gene COMPARTMENTS Subcellular localization image for HNRNPF gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HNRNPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7499401
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with HNRNPF: view

Pathways for HNRNPF Gene

genes like me logo Genes that share pathways with HNRNPF: view

Pathways by source for HNRNPF Gene

Gene Ontology (GO) - Biological Process for HNRNPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006396 RNA processing TAS 7499401
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
GO:0043484 regulation of RNA splicing IMP 9111328
genes like me logo Genes that share ontologies with HNRNPF: view

Transcripts for HNRNPF Gene

Unigene Clusters for HNRNPF Gene

Heterogeneous nuclear ribonucleoprotein F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPF Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - -
SP13: - - - -
SP14: - - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - -
SP18: - - - - - - - - -
SP19: - - - - - - - - - - - - -
SP20: - - - - - - - - - -

ExUns: 10d · 10e · 10f · 10g · 10h · 10i · 10j · 10k · 10l · 10m · 10n
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for HNRNPF Gene

GeneLoc Exon Structure for
HNRNPF
ECgene alternative splicing isoforms for
HNRNPF

Expression for HNRNPF Gene

mRNA expression in normal human tissues for HNRNPF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPF Gene

SOURCE GeneReport for Unigene cluster for HNRNPF Gene Hs.808

mRNA Expression by UniProt/SwissProt for HNRNPF Gene

P52597-HNRPF_HUMAN
Tissue specificity: Expressed ubiquitously
genes like me logo Genes that share expressions with HNRNPF: view

Orthologs for HNRNPF Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPF 36
  • 99.44 (n)
  • 100 (a)
HNRNPF 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HNRNPF 36
  • 90.98 (n)
  • 97.1 (a)
HNRNPF 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPF 36
  • 92.43 (n)
  • 98.07 (a)
HNRNPF 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm6430 37
  • 97 (a)
OneToMany
Hnrnpf 36
  • 91.57 (n)
  • 98.07 (a)
Hnrnpf 16
Hnrnpf 37
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia HNRNPF 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnpf 36
  • 91.49 (n)
  • 98.07 (a)
chicken
(Gallus gallus)
Aves HNRNPH1 37
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 66 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hnrnph1 37
  • 64 (a)
ManyToMany
hnrnph1l 37
  • 65 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea hrpf-1 36
  • 44.55 (n)
  • 37.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToMany
Species with no ortholog for HNRNPF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HNRNPF Gene

ENSEMBL:
Gene Tree for HNRNPF (if available)
TreeFam:
Gene Tree for HNRNPF (if available)

Paralogs for HNRNPF Gene

Paralogs for HNRNPF Gene

Selected SIMAP similar genes for HNRNPF Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HNRNPF Gene

genes like me logo Genes that share paralogs with HNRNPF: view

Variants for HNRNPF Gene

Sequence variations from dbSNP and Humsavar for HNRNPF Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs10409 -- 43,386,473(-) AAATT(C/G/T)TCTTC utr-variant-3-prime
rs1126487 -- 43,387,894(-) CCCTG(A/T)CAAGT utr-variant-5-prime
rs1126709 -- 43,385,646(-) TTTCT(A/C)GTTTT utr-variant-3-prime
rs1338563 -- 43,409,300(-) CGTGT(C/T)GGCTC upstream-variant-2KB
rs1416226 -- 43,408,759(-) TGATA(C/G/T)GAGAG intron-variant, utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HNRNPF Gene

Variant ID Type Subtype PubMed ID
nsv895087 CNV Loss 21882294
nsv831842 CNV Loss 17160897
nsv895088 CNV Loss 21882294
dgv146n67 CNV Gain 20364138
nsv825355 CNV Gain 20364138
esv6684 CNV Gain 19470904

Relevant External Links for HNRNPF Gene

HapMap Linkage Disequilibrium report
HNRNPF

Disorders for HNRNPF Gene

Relevant External Links for HNRNPF

Genetic Association Database (GAD)
HNRNPF
Human Genome Epidemiology (HuGE) Navigator
HNRNPF
genes like me logo Genes that share disorders with HNRNPF: view

No data available for UniProtKB/Swiss-Prot for HNRNPF Gene

Publications for HNRNPF Gene

  1. Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes. (PMID: 7499401) Honore B. … Celis J.E. (J. Biol. Chem. 1995) 2 3 4
  2. The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization. (PMID: 7512260) Matunis M.J. … Dreyfuss G. (Nucleic Acids Res. 1994) 3 4
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  4. Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues. (PMID: 14980514) HonorAc B. … Vorum H. (Exp. Cell Res. 2004) 3 23
  5. Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer. (PMID: 16424007) Balasubramani M. … Getzenberg R.H. (Cancer Res. 2006) 3 23

Products for HNRNPF Gene

Sources for HNRNPF Gene

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