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HNRNPF Gene

protein-coding   GIFtS: 61
GCID: GC10M043881

Heterogeneous Nuclear Ribonucleoprotein F


(Previous symbol: HNRPF)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein F1 2     HnRNP F Protein2
HNRPF1 2 3 5     mcs94-12
Nucleolin-Like Protein Mcs94-12 3     HnRNP F3
OK/SW-cl.232     

External Ids:    HGNC: 50391   Entrez Gene: 31852   Ensembl: ENSG000001698137   OMIM: 6010375   UniProtKB: P525973   

Export aliases for HNRNPF gene to outside databases

Previous GC identifers: GC10M043202 GC10M040407


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPF Gene:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are
associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of
mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between
the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein
encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich
sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants,
encoding the same protein, have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for HNRNPF Gene:
HNRNPF (heterogeneous nuclear ribonucleoprotein F) is a protein-coding gene. Diseases associated with HNRNPF include sipple syndrome, and gout. GO annotations related to this gene include single-stranded RNA binding and RNA binding. An important paralog of this gene is RBM12B.

UniProtKB/Swiss-Prot: HNRPF_HUMAN, P52597
Function: Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate
for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm.
Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps
target RNA in an unfolded state

Gene Wiki entry for HNRNPF (HNRPF) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPF gene promoter:
         Elk-1   Meis-1   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRNPF promoter sequence
   Search Chromatin IP Primers for HNRNPF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.21   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.21

HNRNPF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPF gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M043881:  view genomic region     (about GC identifiers)

Start:
43,881,065 bp from pter      End:
43,904,696 bp from pter
Size:
23,632 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HNRPF_HUMAN, P52597 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein F  
Size: 415 amino acids; 45672 Da
Subunit: Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1
Selected PDB 3D structures from and Proteopedia for HNRNPF (see all 7):
2HGL (3D)        2HGM (3D)        2HGN (3D)        2KFY (3D)        2KG0 (3D)        2KG1 (3D)    
Secondary accessions: B3KM84 Q5T0N2 Q96AU2

Explore the universe of human proteins at neXtProt for HNRNPF: NX_P52597

Explore proteomics data for HNRNPF at MOPED

Post-translational modifications: 

  • Sumoylated1
  • Ubiquitination2 at Lys14, Lys87, Lys98, Lys167, Lys185, Lys200, Lys224, Lys299
  • Modification sites at PhosphoSitePlus

  • See HNRNPF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001091674.1  NP_001091675.1  NP_001091676.1  NP_001091677.1  NP_001091678.1  NP_004957.1  

    ENSEMBL proteins: 
     ENSP00000349573   ENSP00000348345   ENSP00000338477   ENSP00000438061   ENSP00000400433  
    Reactome Protein details: P52597

    HNRNPF Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012996 Znf_CHHC
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P52597

    ProtoNet protein and cluster: P52597

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB012996 Zinc finger


    UniProtKB/Swiss-Prot: HNRPF_HUMAN, P52597
    Domain: The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    HNRNPF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRPF_HUMAN, P52597
    Function: Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate
    for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm.
    Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps
    target RNA in an unfolded state

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS7499401
    GO:0003727single-stranded RNA binding IDA--
    GO:0005515protein binding IPI17932509
         
    HNRNPF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HNRNPF:
     Decreased p24 protein expressi 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target HNRNPF:
    hsa-mir-505-3p (MIRT041015), hsa-mir-27b-3p (MIRT046236), hsa-let-7b-5p (MIRT052092), hsa-mir-328-3p (MIRT043767), hsa-mir-874-3p (MIRT037762), hsa-mir-339-5p (MIRT042766), hsa-mir-10a-5p (MIRT047662), hsa-mir-615-3p (MIRT040073), hsa-mir-10b-5p (MIRT047469), hsa-mir-92a-3p (MIRT049243), hsa-mir-18a-3p (MIRT040847), hsa-mir-16-5p (MIRT051089)

    Block miRNA regulation of human, mouse, rat HNRNPF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPF (see all 55):
    hsa-miR-124* hsa-miR-3685 hsa-miR-3146 hsa-miR-128 hsa-miR-139-5p hsa-miR-29a hsa-miR-200a hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPF 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 6): HNRNPF (NM_001098207)
    Sino Biological Human cDNA Clone for HNRNPF
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HNRPF_HUMAN, P52597: Nucleus, nucleoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS7499401
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0071013catalytic step 2 spliceosome IDA11991638

    HNRNPF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPF About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HNRNPF
        Telomere Extension by Telomerase


    2 Reactome Pathways for HNRNPF
        mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA



    HNRNPF for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPF
    Interactions:

        Search GeneGlobe Interaction Network for HNRNPF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPF (P525972, 3 ENSP000003384774) via UniProtKB, MINT, STRING, and/or I2D (see all 1003)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPH1P319432, 3, ENSP000003491684MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000349168
    NSFP464592, 3MINT-7945693 MINT-7947479 I2D: score=1 
    SRRM2Q9UQ352, 3, ENSP000003017404MINT-7945693 I2D: score=1 STRING: ENSP00000301740
    UBA5Q9GZZ92, 3MINT-7945693 MINT-7947479 I2D: score=1 
    PRPF40AO754002, 3MINT-7945693 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006396RNA processing TAS7499401
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--
    GO:0043484regulation of RNA splicing IMP9111328

    HNRNPF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPF (HNRPF)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HNRNPF gene (6 alternative transcripts): 
    NM_001098204.1  NM_001098205.1  NM_001098206.1  NM_001098207.1  NM_001098208.1  NM_004966.3  

    Unigene Cluster for HNRNPF:

    Heterogeneous nuclear ribonucleoprotein F
    Hs.808  [show with all ESTs]
    Unigene Representative Sequence: NM_001098208
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357065(uc001jas.2 uc001jav.2 uc001jau.2) ENST00000356053(uc001jat.2)
    ENST00000337970 ENST00000477108 ENST00000498176 ENST00000544000(uc001jar.2)
    ENST00000443950(uc009xmh.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat HNRNPF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPF (see all 55):
    hsa-miR-124* hsa-miR-3685 hsa-miR-3146 hsa-miR-128 hsa-miR-139-5p hsa-miR-29a hsa-miR-200a hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPF 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 6): HNRNPF (NM_001098207)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPF
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPF
      QuantiFast Probe-based Assays in human, mouse, rat HNRNPF

    Additional mRNA sequence: 

    AB062287.1 AK001364.1 AK296696.1 BC001432.2 BC004254.1 BC015580.2 BC016736.1 BC106008.1 
    L28010.1 

    Selected DOTS entries (see all 48):

    DT.92463968  DT.95341421  DT.99991983  DT.86855111  DT.100038746  DT.95341433  DT.100038744  DT.101973798 
    DT.100643538  DT.100639461  DT.100657795  DT.92463949  DT.100639456  DT.92463969  DT.121237919  DT.121237926 
    DT.95341435  DT.95341331  DT.121237788  DT.95341422  DT.121237829  DT.100686078  DT.100657802  DT.100657798 

    Selected AceView cDNA sequences (see all 902):

    BQ922616 BM918499 BP360561 BQ722119 BM459996 CD676865 BI756772 BG482187 
    W07799 AA299841 AI921157 BQ959039 AL043726 BG675947 AA864851 BU542485 
    AA554219 BG254343 BQ220363 AI377397 AW518999 BM468313 AA554358 AA307806 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPF (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ·
    SP1:                          -     -     -     -     -     -     -     -     -     -     -     -     -           -     -                                       
    SP2:                          -     -     -     -     -     -     -     -     -     -     -           -           -     -           -     -                     
    SP3:                                                                                -     -     -     -           -     -                                       
    SP4:                                                                                                  -           -     -           -     -                     
    SP5:                          -     -     -     -     -     -     -     -     -     -     -     -     -           -     -           -     -                     

    ExUns: 10d · 10e · 10f · 10g · 10h · 10i · 10j · 10k · 10l · 10m · 10n
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for HNRNPF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTTCATT
    HNRNPF Expression
    About this image


    HNRNPF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
    HNRNPF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.808

    UniProtKB/Swiss-Prot: HNRPF_HUMAN, P52597
    Tissue specificity: Expressed ubiquitously

        Custom PCR Arrays for HNRNPF
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HNRNPF gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpf1 , 5 heterogeneous nuclear ribonucleoprotein F1, 5 91.57(n)1
    98.07(a)1
      6 (55.66 cM)5
    987581  NM_001166427.11  NP_001159899.11 
     1179003245 
    chicken
    (Gallus gallus)
    Aves HNRNPH16
    Gallus gallus heterogeneous nuclear ribonucleoprot...
    59(a)
    1 → many
    13(12896978-12911863)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    66(a)
    1 → many
    2(140417161-140425189)
    zebrafish
    (Danio rerio)
    Actinopterygii hnrnph1l6
    hnrnph16
    heterogeneous nuclear ribonucleoprotein H1
    65(a)
    64(a)
    many ↔ many
    many ↔ many
    21(28913671-28925825) ENSDARG00000005551
    14(6957524-6980892) ENSDARG00000040881
    worm
    (Caenorhabditis elegans)
    Secernentea hrpf-11 hrpf-1 44.55(n)
    37.29(a)
      172395  NM_170888.4  NP_740877.1 


    ENSEMBL Gene Tree for HNRNPF (if available)
    TreeFam Gene Tree for HNRNPF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPF gene
    RBM12B2  HNRNPH32  ESRP12  HNRNPH22  GRSF12  ESRP22  HNRNPH12  RBM122  
    5 SIMAP similar genes for HNRNPF using alignment to 1 protein entry:     HNRPF_HUMAN:
    DKFZp686A15170    HNRNPH1    HNRNPH2    HNRNPH3    GRSF1

    HNRNPF for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HNRNPF
    PGOHUM00000250544


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPF (see all 596)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs741357401,2
    C,F--43880592(+) TGGAAC/GGAAGG 6 -- ds50012Minor allele frequency- G:0.04WA 120
    rs1505191941,2
    --43880593(+) GGAACA/GAAGGG 6 -- ds50010--------
    rs1846935061,2
    --43880614(+) GGTGAA/GCCTCT 6 -- ds50010--------
    rs727852561,2
    C,F--43880649(+) CTGAAG/AACTTC 6 -- ds50012Minor allele frequency- A:0.12WA NA 238
    rs1903733331,2
    --43880666(+) CTAATA/TTTTAA 6 -- ds50010--------
    rs749345041,2
    C--43880800(+) TTGAA-/GAATTCCC 6 -- ds50010--------
    rs1822080041,2
    --43880816(+) AATGGC/TAGATA 6 -- ds50010--------
    rs79205391,2
    C,F,A,H--43880833(+) TTGCAT/CAGAAT 6 -- ds500134Minor allele frequency- C:0.47NA NS EA WA CSA 3332
    rs1152963601,2
    F--43880837(+) ACAGAA/GTGGTT 6 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1855879031,2
    --43880996(+) GCTTGA/TTAATG 6 -- ds50010--------

    HapMap Linkage Disequilibrium report for HNRNPF (43881065 - 43904696 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for HNRNPF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831842CNV Loss17160897
    nsv895087CNV Loss21882294
    nsv895088CNV Loss21882294
    nsv825355CNV Gain20364138
    esv6684CNV Gain19470904
    dgv146n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPF
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601037    OMIM disorders: --

    19 diseases for HNRNPF:    
    About MalaCards
    sipple syndrome    gout    influenza    tonsillitis
    ataxia    pancreatic cancer    hiv-1    pancreatitis
    neuroblastoma    hepatocellular carcinoma    alzheimer's disease    prostatitis
    melanoma    prostate cancer    thyroiditis    cerebritis
    breast cancer    neuronitis    endotheliitis


    HNRNPF for disorders           About GeneDecksing

    Genetic Association Database (GAD): HNRNPF
    Human Genome Epidemiology (HuGE) Navigator: HNRNPF (2 documents)

    Export disorders for HNRNPF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPF gene, integrated from 10 sources (see all 114):
    (articles sorted by number of sources associating them with HNRNPF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes. (PubMed id 7499401)1, 2, 3 Honore B.... Celis J.E. (J. Biol. Chem. 1995)
    2. Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs. (PubMed id 20526337)1, 2 Dominguez C.... Allain F.H. (Nat. Struct. Mol. Biol. 2010)
    3. Proteomic and functional analysis of Argonaute-containing mRNA- protein complexes in human cells. (PubMed id 17932509)1, 2 Hoeck J.... Meister G. (EMBO Rep. 2007)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition. (PubMed id 16885237)1, 2 Dominguez C. and Allain F.H. (Nucleic Acids Res. 2006)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. (PubMed id 15161980)1, 2 Li T.... Chock P.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3185 HGNC: 5039 AceView: HNRPF Ensembl:ENSG00000169813 euGenes: HUgn3185
    ECgene: HNRNPF H-InvDB: HNRNPF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HNRNPF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPF gene:
    Search GeneIP for patents involving HNRNPF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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