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Aliases for HNRNPF Gene

Aliases for HNRNPF Gene

  • Heterogeneous Nuclear Ribonucleoprotein F 2 3 5
  • Nucleolin-Like Protein Mcs94-1 3 4
  • HNRPF 3 4
  • HnRNP F Protein 3
  • OK/SW-Cl.23 3
  • Mcs94-1 3
  • HnRNP F 4

External Ids for HNRNPF Gene

Previous HGNC Symbols for HNRNPF Gene

  • HNRPF

Previous GeneCards Identifiers for HNRNPF Gene

  • GC10M043202
  • GC10M043881
  • GC10M040407

Summaries for HNRNPF Gene

Entrez Gene Summary for HNRNPF Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPF Gene

HNRNPF (Heterogeneous Nuclear Ribonucleoprotein F) is a Protein Coding gene. Among its related pathways are mRNA Capping and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPH1.

UniProtKB/Swiss-Prot for HNRNPF Gene

  • Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.

Gene Wiki entry for HNRNPF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPF Gene

Genomics for HNRNPF Gene

Regulatory Elements for HNRNPF Gene

Enhancers for HNRNPF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F043136 0.8 FANTOM5 ENCODE 16.5 +270.2 270178 4.3 ATF1 CREB3L1 ARID4B SIN3A ZNF2 GLIS2 ELK1 KLF7 FOS ZNF263 CSGALNACT2 HNRNPF ENSG00000273008 RASGEF1A GC10P043154
GH10F043304 1.5 FANTOM5 Ensembl ENCODE 7.1 +104.2 104248 1.2 E2F1 L3MBTL2 ZNF512 CBX2 PRDM10 ZBTB8A UBTF CSGALNACT2 HNRNPF LOC105378271 RASGEF1A
GH10F043120 0.9 FANTOM5 Ensembl ENCODE 4.2 +287.8 287848 2.8 CBX3 WRNIP1 MAX EBF1 ZIC2 RELA EED PRDM10 ETV6 CBFB CSGALNACT2 RASGEF1A HNRNPF GC10M043121 PIR60596
GH10F044043 0.5 ENCODE 4.1 -635.6 -635610 1.9 SMARCA4 POLR2A FEZF1 REST RAD21 NR2F2 LOC101929465 CXCL12 HNRNPF PIR37397 ENSG00000237590
GH10F043392 0.9 FANTOM5 ENCODE 1.6 +7.6 7559 18.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 BMS1 ZNF32-AS2 HNRNPA3P1 LOC105378272 EIF3LP2 ZNF32 ZNF32-AS1 ZNF37BP ZNF239 RASGEF1A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HNRNPF on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000354060 1048 4401 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for HNRNPF Gene

Chromosome:
10
Start:
43,385,617 bp from pter
End:
43,409,248 bp from pter
Size:
23,632 bases
Orientation:
Minus strand

Genomic View for HNRNPF Gene

Genes around HNRNPF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPF Gene

Proteins for HNRNPF Gene

  • Protein details for HNRNPF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52597-HNRPF_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein F
    Protein Accession:
    P52597
    Secondary Accessions:
    • B3KM84
    • Q5T0N2
    • Q96AU2

    Protein attributes for HNRNPF Gene

    Size:
    415 amino acids
    Molecular mass:
    45672 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1.

    Three dimensional structures from OCA and Proteopedia for HNRNPF Gene

neXtProt entry for HNRNPF Gene

Post-translational modifications for HNRNPF Gene

Antibody Products

No data available for DME Specific Peptides for HNRNPF Gene

Domains & Families for HNRNPF Gene

Gene Families for HNRNPF Gene

Graphical View of Domain Structure for InterPro Entry

P52597

UniProtKB/Swiss-Prot:

HNRPF_HUMAN :
  • The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA.
Domain:
  • The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA.
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPF: view

Function for HNRNPF Gene

Molecular function for HNRNPF Gene

UniProtKB/Swiss-Prot Function:
Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.

Gene Ontology (GO) - Molecular Function for HNRNPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding TAS 7499401
GO:0003727 single-stranded RNA binding IDA 20526337
GO:0005515 protein binding IPI 9111328
genes like me logo Genes that share ontologies with HNRNPF: view
genes like me logo Genes that share phenotypes with HNRNPF: view

Animal Model Products

miRNA for HNRNPF Gene

miRTarBase miRNAs that target HNRNPF

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPF Gene

Localization for HNRNPF Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPF Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPF Gene COMPARTMENTS Subcellular localization image for HNRNPF gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HNRNPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7499401
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HNRNPF: view

Pathways & Interactions for HNRNPF Gene

genes like me logo Genes that share pathways with HNRNPF: view

Pathways by source for HNRNPF Gene

Gene Ontology (GO) - Biological Process for HNRNPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006396 RNA processing TAS 7499401
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with HNRNPF: view

No data available for SIGNOR curated interactions for HNRNPF Gene

Transcripts for HNRNPF Gene

Unigene Clusters for HNRNPF Gene

Heterogeneous nuclear ribonucleoprotein F:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPF Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - -
SP13: - - - -
SP14: - - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - -
SP18: - - - - - - - - -
SP19: - - - - - - - - - - - - -
SP20: - - - - - - - - - -

ExUns: 10d · 10e · 10f · 10g · 10h · 10i · 10j · 10k · 10l · 10m · 10n
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for HNRNPF Gene

GeneLoc Exon Structure for
HNRNPF
ECgene alternative splicing isoforms for
HNRNPF

Expression for HNRNPF Gene

mRNA expression in normal human tissues for HNRNPF Gene

Protein differential expression in normal tissues from HIPED for HNRNPF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPF Gene



Protein tissue co-expression partners for HNRNPF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPF Gene:

HNRNPF

SOURCE GeneReport for Unigene cluster for HNRNPF Gene:

Hs.808

mRNA Expression by UniProt/SwissProt for HNRNPF Gene:

P52597-HNRPF_HUMAN
Tissue specificity: Expressed ubiquitously.
genes like me logo Genes that share expression patterns with HNRNPF: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HNRNPF Gene

Orthologs for HNRNPF Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPF 34 35
  • 99.44 (n)
mouse
(Mus musculus)
Mammalia Gm6430 35
  • 97 (a)
OneToMany
Hnrnpf 34 16 35
  • 91.57 (n)
dog
(Canis familiaris)
Mammalia HNRNPF 34 35
  • 92.43 (n)
rat
(Rattus norvegicus)
Mammalia Hnrnpf 34
  • 91.49 (n)
cow
(Bos Taurus)
Mammalia HNRNPF 34 35
  • 90.98 (n)
oppossum
(Monodelphis domestica)
Mammalia HNRNPF 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPH1 35
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 66 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hnrnph1l 35
  • 65 (a)
ManyToMany
hnrnph1 35
  • 64 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea hrpf-1 34
  • 44.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
Species where no ortholog for HNRNPF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HNRNPF Gene

ENSEMBL:
Gene Tree for HNRNPF (if available)
TreeFam:
Gene Tree for HNRNPF (if available)

Paralogs for HNRNPF Gene

Paralogs for HNRNPF Gene

(5) SIMAP similar genes for HNRNPF Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HNRNPF Gene

genes like me logo Genes that share paralogs with HNRNPF: view

Variants for HNRNPF Gene

Sequence variations from dbSNP and Humsavar for HNRNPF Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10409 -- 43,386,473(-) AAATT(C/T)TCTTC utr-variant-3-prime
rs10659782 -- 43,391,672(+) CCAGG(-/AG)AGTTT intron-variant
rs10732897 -- 43,398,096(+) GATCT(C/T)GGCTC intron-variant, upstream-variant-2KB
rs10793430 -- 43,388,197(+) GCAAG(G/T)GCATT intron-variant
rs10793431 -- 43,388,854(+) AGGGT(A/C)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPF Gene

Variant ID Type Subtype PubMed ID
dgv146n67 CNV gain 20364138
esv3578785 CNV loss 25503493
esv3623043 CNV loss 21293372
esv6684 CNV gain 19470904
nsv825355 CNV gain 20364138
nsv831842 CNV loss 17160897
nsv951568 CNV deletion 24416366

Variation tolerance for HNRNPF Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPF Gene

Disorders for HNRNPF Gene

Relevant External Links for HNRNPF

Genetic Association Database (GAD)
HNRNPF
Human Genome Epidemiology (HuGE) Navigator
HNRNPF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPF

No disorders were found for HNRNPF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPF Gene

Publications for HNRNPF Gene

  1. Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes. (PMID: 7499401) Honore B. … Celis J.E. (J. Biol. Chem. 1995) 2 3 4 64
  2. Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs. (PMID: 20526337) Dominguez C. … Allain F.H. (Nat. Struct. Mol. Biol. 2010) 3 4 64
  3. Proteomic and functional analysis of Argonaute-containing mRNA- protein complexes in human cells. (PMID: 17932509) Hoeck J. … Meister G. (EMBO Rep. 2007) 3 4 64
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  5. NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition. (PMID: 16885237) Dominguez C. … Allain F.H. (Nucleic Acids Res. 2006) 3 4 64

Products for HNRNPF Gene

Sources for HNRNPF Gene

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