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HNRNPDL Gene

protein-coding   GIFtS: 41
GCID: GC04M083344

Heterogeneous Nuclear Ribonucleoprotein D-Like


(Previous symbol: HNRPDL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein D-Like1 2     HnRNP DL2 3
HNRPDL1 2 3 5     JKT41-Binding Protein2 3
JKTBP2 3 5     HNRNP2
Protein LaAUF12 3     JKTBP22
AU-Rich Element RNA-Binding Factor2 3     A+U-Rich Element RNA Binding Factor2
HnRNP D-Like2 3     laAUF12

External Ids:    HGNC: 50371   Entrez Gene: 99872   Ensembl: ENSG000001527957   OMIM: 6071375   UniProtKB: O149793   

Export aliases for HNRNPDL gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPDL Gene:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are
associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA
metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the
nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded
by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been
described for this gene. One of the variants is probably not translated because the transcript is a candidate for
nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD.
(provided by RefSeq, May 2011)

GeneCards Summary for HNRNPDL Gene:
HNRNPDL (heterogeneous nuclear ribonucleoprotein D-like) is a protein-coding gene. Diseases associated with HNRNPDL include mixed connective tissue disease, and rheumatic disease. GO annotations related to this gene include double-stranded DNA binding and RNA binding. An important paralog of this gene is HNRNPA1.

UniProtKB/Swiss-Prot: HNRDL_HUMAN, O14979
Function: Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription
activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds
to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to
RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine
mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or
poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence

Gene Wiki entry for HNRNPDL (HNRPDL) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for HNRNPDL
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRNPDL promoter sequence
   Search Chromatin IP Primers for HNRNPDL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPDL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.22   Ensembl cytogenetic band:  4q21.22   HGNC cytogenetic band: 4q21.22

HNRNPDL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPDL gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M083344:  view genomic region     (about GC identifiers)

Start:
83,343,717 bp from pter      End:
83,351,378 bp from pter
Size:
7,662 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HNRDL_HUMAN, O14979 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein D-like  
Size: 420 amino acids; 46438 Da
Subunit: Interacts with ZNF148 (By similarity). Interacts with TNPO1
Sequence caution: Sequence=BAA22860.1; Type=Erroneous initiation;
Secondary accessions: Q6SPF2 Q7KZ74 Q7KZ75 Q96IM0 Q96S43
Alternative splicing: 3 isoforms:  O14979-1   O14979-2   O14979-3   

Explore the universe of human proteins at neXtProt for HNRNPDL: NX_O14979

Explore proteomics data for HNRNPDL at MOPED

Post-translational modifications: 

  • Dimethylation of Arg-408 is probably of the asymmetric type1
  • Ubiquitination2 at Lys137, Lys149, Lys162, Lys197, Lys204, Lys234, Lys302
  • Modification sites at PhosphoSitePlus

  • See HNRNPDL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001193929.1  NP_112740.1  

    ENSEMBL proteins: 
     ENSP00000295470   ENSP00000473677   ENSP00000422040   ENSP00000338552  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O14979

    ProtoNet protein and cluster: O14979

    UniProtKB/Swiss-Prot: HNRDL_HUMAN, O14979
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    HNRNPDL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRDL_HUMAN, O14979
    Function: Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription
    activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds
    to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to
    RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine
    mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or
    poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence
    Induction: Up-regulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) in macrophages and retinoic acid (RA) in
    granulocytes (at protein level). Down-regulated by IL4/interleukin-4

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003690double-stranded DNA binding IDA9538234
    GO:0003697single-stranded DNA binding IDA9538234
         
    HNRNPDL for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HNRNPDL:
     Decreased homologous recombina 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HNRDL_HUMAN, O14979: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent
    manner

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex NAS9538234
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    HNRNPDL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPDL
    Interactions:

        Search GeneGlobe Interaction Network for HNRNPDL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPDL (O149792, 3 ENSP000002954704) via UniProtKB, MINT, STRING, and/or I2D (see all 342)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    ATICP319393, ENSP000002369594I2D: score=2 STRING: ENSP00000236959
    HNRNPA1P096513, ENSP000003418264I2D: score=1 STRING: ENSP00000341826
    KHDRBS2Q5VWX13, ENSP000002811564I2D: score=1 STRING: ENSP00000281156
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006396RNA processing NAS9538234
    GO:0010468regulation of gene expression IDA9538234

    HNRNPDL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPDL (HNRDL)

    1 Novoseek inferred chemical compound relationship for HNRNPDL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nacl 6.07 1 10793134 (1)



    HNRNPDL for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HNRNPDL gene (3 alternative transcripts): 
    NM_001207000.1  NM_031372.3  NM_005463.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295470(uc003hmq.3 uc003hmr.3 uc003hmt.3) ENST00000602300
    ENST00000502762 ENST00000507721 ENST00000514511 ENST00000349655
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      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPDL
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    Selected AceView cDNA sequences (see all 896):

    BM702014 AI131259 AI499671 BI966175 AA211588 BC071944 AA164817 AI217391 
    AI027830 AU137724 BQ267854 CB156192 N68140 CA394290 D89092 CB115471 
    AA776588 AY453824 AA377542 CR605042 CR593853 AL537852 CD364798 AI831039 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPDL (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
    SP1:                                                  -     -                 -                                               -     -                     
    SP2:                                                  -     -                 -                                   -           -     -                     
    SP3:                                                  -     -                                                                                             
    SP4:                                                                                                                          -                           
    SP5:        -     -     -     -                       -     -                 -                                                                           


    ECgene alternative splicing isoforms for HNRNPDL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPDL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HNRNPDL Expression
    About this image

    HNRNPDL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPDL Protein Expression

    UniProtKB/Swiss-Prot: HNRDL_HUMAN, O14979
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen,
    thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric
    adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma,
    osteosarcoma and urinary bladder carcinoma cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HNRNPDL gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrpdl5
    Hnrnpdl1
    heterogeneous nuclear ribonucleoprotein D-like1, 5 93.33(n)1
    97.14(a)1
      5 (48.46 cM)5
    509261  NM_016690.41  NP_057899.21 
     1000335775 
    chicken
    (Gallus gallus)
    Aves HNRNPDL1 heterogeneous nuclear ribonucleoprotein D-like 79.89(n)
    94.33(a)
      422601  NM_001031142.1  NP_001026313.1 
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPDL6
    heterogeneous nuclear ribonucleoprotein D-like
    87(a)
    1 ↔ 1
    5(42900651-42908629)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC533102 similar to heterogeneous nuclear ribonucleoprotein more 77.43(n)    BC045124.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11d082 Danio rerio cDNA clone MGC66169 IMAGE5601422, complete more 78.63(n)    BC055525.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sqd6
    squid
    36(a)
    1 → many
    3R(9460679-9472026)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRP16
    Subunit of cleavage factor I, a five-subunit compl...
    21(a)
    1 → many
    XV(87844-89448) YOL123W


    ENSEMBL Gene Tree for HNRNPDL (if available)
    TreeFam Gene Tree for HNRNPDL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPDL gene
    HNRNPA12  HNRNPD2  HNRNPA32  HNRNPA02  HNRNPAB2  HNRNPA1L22  HNRNPA2B12  
    10 SIMAP similar genes for HNRNPDL using alignment to 1 protein entry:     HNRDL_HUMAN:
    HNRNPD    HNRNPAB    HNRNPA2B1    HNRNPA1    HNRNPA1L2    HNRPA1
    HNRNPA0    HNRPA3    HNRNPA3    MSI2

    HNRNPDL for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for HNRNPDL
    PGOHUM00000234454 PGOHUM00000240995 PGOHUM00000241649 PGOHUM00000241896 PGOHUM00000241897


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPDL (see all 303)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1498175621,2
    Cuntested183166174(+) GCGGCA/GGAGCG 5 S syn10--------
    rs345830141,2
    C--79088666(+) TCATT-/AAGA  
            
    TAGTT
    3 -- int10--------
    rs1117888951,2
    C--79088666(+) TCATTA/TAGATA 3 -- int10--------
    rs767398831,2
    C--79088669(+) TTAAGA/TTAGTT 3 -- int10--------
    rs1503849321,2
    --83158884(+) CGTGCC/GGCCAG 3 -- ds50010--------
    rs350288631,2
    C,F--83158891(+) CCAGCT/ATAGTC 3 -- ds50016Minor allele frequency- A:0.38NA CSA WA EA 363
    rs1831055221,2
    --83158898(+) AGTCAA/GCTTTT 3 -- ds50010--------
    rs1155859321,2
    C,F--83159025(+) GCAATC/TGTCCC 3 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1878344311,2
    --83159059(+) TACAGA/GTGTGC 3 -- ds50010--------
    rs1386979771,2
    --83159064(+) GTGTGC/TACCAT 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for HNRNPDL (83343717 - 83351378 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HNRNPDL: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPDL
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPDL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607137    OMIM disorders: --

    Selected diseases for HNRNPDL (see all 27):    About MalaCards
    mixed connective tissue disease    rheumatic disease    connective tissue disease    bladder carcinoma
    fibrosarcoma    gastric adenocarcinoma    colon adenocarcinoma    oral squamous cell carcinoma
    retinoblastoma    osteosarcoma    hiv-1    lupus erythematosus
    rheumatoid arthritis    myeloid leukemia    cervicitis    arthritis
    obesity    neuroblastoma    squamous cell carcinoma    adenocarcinoma


    HNRNPDL for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for HNRNPDL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mixed connective tissue disease 55.9 3 12567457 (1), 8843857 (1), 17453722 (1)
    rheumatic diseases 20.5 1 12567457 (1)
    lupus erythematosus systemic 11.4 3 12567457 (1), 8843857 (1), 17453722 (1)
    shock 0 3 8999868 (1), 10212141 (1)
    rheumatoid arthritis 0 3 12567457 (1), 8843857 (1), 17453722 (1)
    tumors 0 2 10632338 (2)


    Export disorders for HNRNPDL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPDL gene, integrated from 10 sources (see all 133):
    (articles sorted by number of sources associating them with HNRNPDL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two forms of expression and genomic structure of the human heterogeneous nuclear ribonucleoprotein D-like JKTBP gene (HNRPDL). (PubMed id 10072754)1, 2, 3, 9 Kamei D.... Yamada M. (Gene 1999)
    2. Molecular cloning of the cDNA encoding A + U-rich element RNA binding factor. (PubMed id 9524220)1, 2, 3 Doi A.... Fujita S. (Biochim. Biophys. Acta 1998)
    3. Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and heterogeneous nuclear ribonucleoprotein D-like protein (JKTBP1) reciprocally regulate transcription activity by physical interaction with the BERF-1/ZBP-89 factor. (PubMed id 15190078)1, 2 Boopathi E.... Avadhani N.G. (J. Biol. Chem. 2004)
    4. Identification of the nucleocytoplasmic shuttling sequence of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its interaction with mRNA. (PubMed id 11705999)1, 2 Kawamura H.... Yamada M. (J. Biol. Chem. 2002)
    5. Cloning and characterization of a cDNA encoding a novel heterogeneous nuclear ribonucleoprotein-like protein and its expression in myeloid leukemia cells. (PubMed id 9538234)1, 2 Tsuchiya N.... Yamada M. (J. Biochem. 1998)
    6. Interactions of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its domains with high-affinity binding sites. (PubMed id 12406575)2, 9 Kamei D. and Yamada M. (Gene 2002)
    7. Overexpression of JKTBP1 induces androgen-independent LNCaP cell proliferation through activation of epidermal growth factor-receptor (EGF-R). (PubMed id 18381662)1, 9 Wu Y.Y....Wei Y.Q. (Cell Biochem. Funct. 2008)
    8. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)
    9. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    10. Proteomic analyses and identification of arginine methylated proteins differentially recognized by autosera from anti-Sm positive SLE patients. (PubMed id 23642268)1 Chang H.H....Li C. (J. Biomed. Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9987 HGNC: 5037 AceView: HNRPDL Ensembl:ENSG00000152795 euGenes: HUgn9987
    ECgene: HNRNPDL H-InvDB: HNRNPDL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HNRNPDL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HNRNPDL gene:
    Search GeneIP for patents involving HNRNPDL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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