Aliases for HNRNPDL Gene
External Ids for HNRNPDL Gene
Previous HGNC Symbols for HNRNPDL Gene
Previous GeneCards Identifiers for HNRNPDL Gene
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011]
GeneCards Summary for HNRNPDL Gene
HNRNPDL (Heterogeneous Nuclear Ribonucleoprotein D Like) is a Protein Coding gene. Diseases associated with HNRNPDL include limb-girdle muscular dystrophy, type 1g and chromosome 4q21 deletion syndrome. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is HNRNPA0.
UniProtKB/Swiss-Prot for HNRNPDL Gene
Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5-ACUAGC-3 RNA consensus sequence.