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Aliases for HNRNPD Gene

Aliases for HNRNPD Gene

  • Heterogeneous Nuclear Ribonucleoprotein D 2 3 5
  • AU-Rich Element RNA Binding Protein 1, 37kDa 2 3
  • HnRNP D0 3 4
  • HNRPD 3 4
  • AUF1 3 4
  • Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding Protein 1, 37kDa) 3
  • Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA-Binding Protein 1, 37kD) 2
  • AU-Rich Element RNA-Binding Protein 1 4
  • ARE-Binding Protein AUFI, Type A 3
  • HnRNPD0 3
  • AUF1A 3
  • P37 3

External Ids for HNRNPD Gene

Previous HGNC Symbols for HNRNPD Gene

  • AUF1
  • HNRPD

Previous GeneCards Identifiers for HNRNPD Gene

  • GC04M083494
  • GC04M083274
  • GC04M079015

Summaries for HNRNPD Gene

Entrez Gene Summary for HNRNPD Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPD Gene

HNRNPD (Heterogeneous Nuclear Ribonucleoprotein D) is a Protein Coding gene. Diseases associated with HNRNPD include chromosome 4q21 deletion syndrome. Among its related pathways are Translational Control and Telomere Extension by Telomerase. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPA0.

UniProtKB/Swiss-Prot for HNRNPD Gene

  • Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5-UUAG-3 sequence and also weaker to the single-stranded 5-TTAGGG-3 telomeric DNA repeat. Binds RNA oligonucleotides with 5-UUAGGG-3 repeats more tightly than the telomeric single-stranded DNA 5-TTAGGG-3 repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.

Gene Wiki entry for HNRNPD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPD Gene

Genomics for HNRNPD Gene

Regulatory Elements for HNRNPD Gene

Enhancers for HNRNPD Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HNRNPD on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HNRNPD on UCSC Golden Path with GeneCards custom track

Genomic Location for HNRNPD Gene

Chromosome:
4
Start:
82,352,498 bp from pter
End:
82,374,503 bp from pter
Size:
22,006 bases
Orientation:
Minus strand

Genomic View for HNRNPD Gene

Genes around HNRNPD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPD Gene

Proteins for HNRNPD Gene

  • Protein details for HNRNPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14103-HNRPD_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein D0
    Protein Accession:
    Q14103
    Secondary Accessions:
    • A8K9J2
    • P07029
    • Q01858
    • Q14100
    • Q14101
    • Q14102
    • Q4W5A1
    • Q9UCE8
    • Q9UCE9

    Protein attributes for HNRNPD Gene

    Size:
    355 amino acids
    Molecular mass:
    38434 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR and SYNCRIP. Interacts with IGF2BP2. Interacts with GTPBP1. Interacts with EIF4G1; the interaction requires RNA. Interacts with EIF3B and RPS3.
    SequenceCaution:
    • Sequence=AAA35781.1; Type=Frameshift; Positions=45, 59, 355; Evidence={ECO:0000305}; Sequence=AAA35781.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=CAA27544.1; Type=Miscellaneous discrepancy; Note=Several sequence conflicts.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPD Gene

    Alternative splice isoforms for HNRNPD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPD Gene

Proteomics data for HNRNPD Gene at MOPED

Post-translational modifications for HNRNPD Gene

  • Arg-345 is dimethylated, probably to asymmetric dimethylarginine.
  • Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates tyrosine phosphorylation (By similarity).
  • Ubiquitination at Lys 114, Lys 119, Lys 183, Lys 231, Lys 260, and Lys 292
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPD Gene

Domains & Families for HNRNPD Gene

Gene Families for HNRNPD Gene

Suggested Antigen Peptide Sequences for HNRNPD Gene

Graphical View of Domain Structure for InterPro Entry

Q14103

UniProtKB/Swiss-Prot:

HNRPD_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPD: view

Function for HNRNPD Gene

Molecular function for HNRNPD Gene

UniProtKB/Swiss-Prot Function:
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5-UUAG-3 sequence and also weaker to the single-stranded 5-TTAGGG-3 telomeric DNA repeat. Binds RNA oligonucleotides with 5-UUAGGG-3 repeats more tightly than the telomeric single-stranded DNA 5-TTAGGG-3 repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.

Gene Ontology (GO) - Molecular Function for HNRNPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003682 chromatin binding IEA --
GO:0035925 mRNA 3-UTR AU-rich region binding IEA --
GO:0042162 telomeric DNA binding IDA 8321232
genes like me logo Genes that share ontologies with HNRNPD: view
genes like me logo Genes that share phenotypes with HNRNPD: view

Animal Models for HNRNPD Gene

MGI Knock Outs for HNRNPD:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HNRNPD Gene

Localization for HNRNPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPD Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPD Gene COMPARTMENTS Subcellular localization image for HNRNPD gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for HNRNPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HNRNPD: view

Pathways & Interactions for HNRNPD Gene

genes like me logo Genes that share pathways with HNRNPD: view

Pathways by source for HNRNPD Gene

1 Cell Signaling Technology pathway for HNRNPD Gene
1 BioSystems pathway for HNRNPD Gene

SIGNOR curated interactions for HNRNPD Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HNRNPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001889 liver development IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 1433497
GO:0006396 RNA processing TAS 10205060
GO:0006401 RNA catabolic process TAS 10205060
genes like me logo Genes that share ontologies with HNRNPD: view

Drugs & Compounds for HNRNPD Gene

(3) Drugs for HNRNPD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for HNRNPD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HNRNPD: view

Transcripts for HNRNPD Gene

Unigene Clusters for HNRNPD Gene

Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b
SP1: - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6:
SP7: - - -
SP8: - - -
SP9:
SP10:
SP11: - -

Relevant External Links for HNRNPD Gene

GeneLoc Exon Structure for
HNRNPD
ECgene alternative splicing isoforms for
HNRNPD

Expression for HNRNPD Gene

mRNA expression in normal human tissues for HNRNPD Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPD Gene



SOURCE GeneReport for Unigene cluster for HNRNPD Gene Hs.480073

genes like me logo Genes that share expression patterns with HNRNPD: view

Protein tissue co-expression partners for HNRNPD Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPD Gene

Orthologs for HNRNPD Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPD Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HNRNPD 35
  • 98.03 (n)
  • 99.44 (a)
HNRNPD 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpd 35
  • 93.99 (n)
  • 95.49 (a)
Hnrnpd 16
Hnrnpd 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HNRNPD 35
  • 99.91 (n)
  • 100 (a)
HNRNPD 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrpd 35
  • 93.01 (n)
  • 94.9 (a)
cow
(Bos Taurus)
Mammalia HNRPD 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPD 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPD 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPD 35
  • 88.85 (n)
  • 98.83 (a)
HNRNPD 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPD 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpd 35
  • 75.12 (n)
  • 82.25 (a)
Str.8893 35
zebrafish
(Danio rerio)
Actinopterygii hnrnpd 35
  • 74.91 (n)
  • 86.91 (a)
hnrnpd 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sqd 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10292 36
  • 37 (a)
ManyToMany
CSA.5495 36
  • 41 (a)
ManyToMany
Species with no ortholog for HNRNPD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPD Gene

ENSEMBL:
Gene Tree for HNRNPD (if available)
TreeFam:
Gene Tree for HNRNPD (if available)

Paralogs for HNRNPD Gene

Paralogs for HNRNPD Gene

Pseudogenes.org Pseudogenes for HNRNPD Gene

genes like me logo Genes that share paralogs with HNRNPD: view

Variants for HNRNPD Gene

Sequence variations from dbSNP and Humsavar for HNRNPD Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3944 -- 82,353,646(+) AAGTC(A/G)TTCCC utr-variant-3-prime
rs11074 -- 82,353,330(+) CATAA(A/T)CACGG utr-variant-3-prime
rs1135946 -- 82,363,269(-) acccc(A/G)tctct intron-variant
rs1045146 -- 82,370,779(-) GTCTT(C/T)CTGCT intron-variant
rs1045147 -- 82,370,683(-) TCTTT(A/C)CAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPD Gene

Variant ID Type Subtype PubMed ID
nsv829988 CNV Loss 17160897

Variation tolerance for HNRNPD Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPD Gene

HapMap Linkage Disequilibrium report
HNRNPD
Human Gene Mutation Database (HGMD)
HNRNPD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPD Gene

Disorders for HNRNPD Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNRNPD Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 4q21 deletion syndrome
  • 4q21 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HNRNPD

Genetic Association Database (GAD)
HNRNPD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPD
genes like me logo Genes that share disorders with HNRNPD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPD Gene

Publications for HNRNPD Gene

  1. The human HNRPD locus maps to 4q21 and encodes a highly conserved protein. (PMID: 9615222) Dempsey L.A. … Maizels N. (Genomics 1998) 2 3 4 67
  2. HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. (PMID: 20102719) VA!zquez-Chantada M. … MartA-nez-Chantar M.L. (Gastroenterology 2010) 3 23
  3. Similar regulation of human inducible nitric-oxide synthase expression by different isoforms of the RNA-binding protein AUF1. (PMID: 19074427) Pautz A. … Kleinert H. (J. Biol. Chem. 2009) 3 23
  4. The role of AUF1 in thyroid carcinoma progression. (PMID: 19574297) Trojanowicz B. … Hoang-Vu C. (Endocr. Relat. Cancer 2009) 3 23
  5. Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay. (PMID: 18573886) Sinsimer K.S. … Brewer G. (Mol. Cell. Biol. 2008) 3 23

Products for HNRNPD Gene

Sources for HNRNPD Gene

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