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Aliases for HNRNPD Gene

Aliases for HNRNPD Gene

  • Heterogeneous Nuclear Ribonucleoprotein D 2 3 5
  • AU-Rich Element RNA Binding Protein 1, 37kDa 2 3
  • HnRNP D0 3 4
  • HNRPD 3 4
  • AUF1 3 4
  • Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA-Binding Protein 1, 37kD) 2
  • Heterogeneous Nuclear Ribonucleoprotein D0 3
  • AU-Rich Element RNA-Binding Protein 1 4
  • ARE-Binding Protein AUFI, Type A 3
  • HnRNPD0 3
  • AUF1A 3
  • P37 3

External Ids for HNRNPD Gene

Previous HGNC Symbols for HNRNPD Gene

  • AUF1
  • HNRPD

Previous GeneCards Identifiers for HNRNPD Gene

  • GC04M083494
  • GC04M083274
  • GC04M079015

Summaries for HNRNPD Gene

Entrez Gene Summary for HNRNPD Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPD Gene

HNRNPD (Heterogeneous Nuclear Ribonucleoprotein D) is a Protein Coding gene. Diseases associated with HNRNPD include Chromosome 4Q21 Deletion Syndrome. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Translational Control. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPAB.

UniProtKB/Swiss-Prot for HNRNPD Gene

  • Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5-UUAG-3 sequence and also weaker to the single-stranded 5-TTAGGG-3 telomeric DNA repeat. Binds RNA oligonucleotides with 5-UUAGGG-3 repeats more tightly than the telomeric single-stranded DNA 5-TTAGGG-3 repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.

Gene Wiki entry for HNRNPD Gene

Additional gene information for HNRNPD Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPD Gene

Genomics for HNRNPD Gene

Regulatory Elements for HNRNPD Gene

Enhancers for HNRNPD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H082370 1.4 ENCODE dbSUPER 55.8 +1.0 1049 5 MLX DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A SSRP1 ZNF610 GLIS1 HNRNPD HNRNPDL THAP9-AS1 SEC31A ENSG00000199530 LOC101928963 ENOPH1 TMEM150C PIR50483
GH04H082427 1.6 Ensembl ENCODE dbSUPER 37.8 -55.0 -54969 4 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 HNRNPD HNRNPDL ENOPH1 GC04M082403 ENSG00000202440
GH04H083033 1.2 ENCODE 39.3 -660.8 -660785 2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 HNRNPD HELQ THAP9-AS1 ABRAXAS1 HNRNPDL SEC31A GC04P083035 COPS4
GH04H082898 1.4 ENCODE dbSUPER 30.6 -525.9 -525911 4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 THAP9-AS1 HNRNPD HELQ ABRAXAS1 THAP9 GC04P082899
GH04H083254 1.5 Ensembl ENCODE dbSUPER 25.7 -883.6 -883584 6 PKNOX1 FOXA2 FEZF1 ZNF143 ATF7 FOS RUNX3 TSHZ1 REST PPARG HNRNPD HNRNPDL HELQ SEC31A ABRAXAS1 LOC391674 THAP9-AS1 PLAC8 PIR52005 GC04P083274
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HNRNPD on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000169990 1003 5001 MLX DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A SSRP1 ZNF610 GLIS1

Genomic Location for HNRNPD Gene

Chromosome:
4
Start:
82,352,498 bp from pter
End:
82,374,503 bp from pter
Size:
22,006 bases
Orientation:
Minus strand

Genomic View for HNRNPD Gene

Genes around HNRNPD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPD Gene

Proteins for HNRNPD Gene

  • Protein details for HNRNPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14103-HNRPD_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein D0
    Protein Accession:
    Q14103
    Secondary Accessions:
    • A8K9J2
    • P07029
    • Q01858
    • Q14100
    • Q14101
    • Q14102
    • Q4W5A1
    • Q9UCE8
    • Q9UCE9

    Protein attributes for HNRNPD Gene

    Size:
    355 amino acids
    Molecular mass:
    38434 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR and SYNCRIP. Interacts with IGF2BP2. Interacts with GTPBP1. Interacts with EIF4G1; the interaction requires RNA. Interacts with EIF3B and RPS3.
    SequenceCaution:
    • Sequence=AAA35781.1; Type=Frameshift; Positions=45, 59, 355; Evidence={ECO:0000305}; Sequence=AAA35781.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=CAA27544.1; Type=Miscellaneous discrepancy; Note=Several sequence conflicts.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPD Gene

    Alternative splice isoforms for HNRNPD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPD Gene

Post-translational modifications for HNRNPD Gene

  • Arg-345 is dimethylated, probably to asymmetric dimethylarginine.
  • Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates tyrosine phosphorylation (By similarity).
  • Ubiquitination at isoforms=2, 3, 4114, isoforms=2, 3, 4119, posLast=183183, isoforms=2, 3, 4231, posLast=260260, and isoforms=4292
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HNRNPD (hnRNP D0)

No data available for DME Specific Peptides for HNRNPD Gene

Domains & Families for HNRNPD Gene

Gene Families for HNRNPD Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HNRNPD Gene

Suggested Antigen Peptide Sequences for HNRNPD Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPD: view

No data available for UniProtKB/Swiss-Prot for HNRNPD Gene

Function for HNRNPD Gene

Molecular function for HNRNPD Gene

UniProtKB/Swiss-Prot Function:
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5-UUAG-3 sequence and also weaker to the single-stranded 5-TTAGGG-3 telomeric DNA repeat. Binds RNA oligonucleotides with 5-UUAGGG-3 repeats more tightly than the telomeric single-stranded DNA 5-TTAGGG-3 repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.

Gene Ontology (GO) - Molecular Function for HNRNPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003680 AT DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding NAS,IEA 3754960
genes like me logo Genes that share ontologies with HNRNPD: view
genes like me logo Genes that share phenotypes with HNRNPD: view

Animal Models for HNRNPD Gene

MGI Knock Outs for HNRNPD:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HNRNPD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HNRNPD Gene

Localization for HNRNPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPD Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPD gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,TAS 1433497
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0019013 viral nucleocapsid IEA --
genes like me logo Genes that share ontologies with HNRNPD: view

Pathways & Interactions for HNRNPD Gene

genes like me logo Genes that share pathways with HNRNPD: view

Pathways by source for HNRNPD Gene

1 Cell Signaling Technology pathway for HNRNPD Gene
2 BioSystems pathways for HNRNPD Gene

SIGNOR curated interactions for HNRNPD Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HNRNPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001889 liver development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 1433497
GO:0006396 RNA processing TAS 10205060
genes like me logo Genes that share ontologies with HNRNPD: view

Drugs & Compounds for HNRNPD Gene

(3) Drugs for HNRNPD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for HNRNPD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HNRNPD: view

Transcripts for HNRNPD Gene

Unigene Clusters for HNRNPD Gene

Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HNRNPD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b
SP1: - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6:
SP7: - - -
SP8: - - -
SP9:
SP10:
SP11: - -

Relevant External Links for HNRNPD Gene

GeneLoc Exon Structure for
HNRNPD
ECgene alternative splicing isoforms for
HNRNPD

Expression for HNRNPD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPD Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPD Gene



Protein tissue co-expression partners for HNRNPD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPD Gene:

HNRNPD

SOURCE GeneReport for Unigene cluster for HNRNPD Gene:

Hs.480073

Evidence on tissue expression from TISSUES for HNRNPD Gene

  • Lung(4.7)
  • Liver(4.5)
  • Blood(4.4)
  • Nervous system(4.2)
  • Muscle(2.7)
  • Thyroid gland(2.7)
  • Kidney(2.6)
  • Intestine(2.5)
  • Spleen(2.5)
  • Heart(2.3)
  • Bone marrow(2.2)
  • Lymph node(2.2)
  • Skin(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with HNRNPD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPD Gene

Orthologs for HNRNPD Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPD Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPD 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HNRNPD 33 34
  • 99.91 (n)
cow
(Bos Taurus)
Mammalia HNRPD 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPD 33 34
  • 98.03 (n)
mouse
(Mus musculus)
Mammalia Hnrnpd 33 16 34
  • 93.99 (n)
rat
(Rattus norvegicus)
Mammalia Hnrpd 33
  • 93.01 (n)
oppossum
(Monodelphis domestica)
Mammalia HNRNPD 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPD 33 34
  • 88.85 (n)
lizard
(Anolis carolinensis)
Reptilia HNRNPD 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpd 33
  • 75.12 (n)
Str.8893 33
zebrafish
(Danio rerio)
Actinopterygii hnrnpd 33 34
  • 74.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta sqd 34
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5495 34
  • 41 (a)
ManyToMany
CSA.10292 34
  • 37 (a)
ManyToMany
Species where no ortholog for HNRNPD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPD Gene

ENSEMBL:
Gene Tree for HNRNPD (if available)
TreeFam:
Gene Tree for HNRNPD (if available)

Paralogs for HNRNPD Gene

Variants for HNRNPD Gene

Sequence variations from dbSNP and Humsavar for HNRNPD Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000020840 -- 82,372,187(+) AAAAG(A/G)AATGG intron-variant, upstream-variant-2KB
rs1000140846 -- 82,373,033(+) CAAAC(A/G)GAGAA intron-variant, upstream-variant-2KB
rs1000264328 -- 82,373,634(+) CCGTT(-/GCC)GCCGC upstream-variant-2KB, cds-indel
rs10003180 -- 82,367,272(+) TAAGG(G/T)AAACT intron-variant
rs1000346487 -- 82,363,694(+) GAGTA(A/T)CTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPD Gene

Variant ID Type Subtype PubMed ID
nsv594743 CNV loss 21841781
nsv829988 CNV loss 17160897
nsv950348 CNV duplication 24416366

Variation tolerance for HNRNPD Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPD Gene

Human Gene Mutation Database (HGMD)
HNRNPD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPD Gene

Disorders for HNRNPD Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNRNPD Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
chromosome 4q21 deletion syndrome
  • 4q21 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HNRNPD

Genetic Association Database (GAD)
HNRNPD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPD
genes like me logo Genes that share disorders with HNRNPD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPD Gene

Publications for HNRNPD Gene

  1. Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0. (PMID: 10080887) Nagata T … Katahira M (Journal of molecular biology 1999) 3 4 22 60
  2. The human HNRPD locus maps to 4q21 and encodes a highly conserved protein. (PMID: 9615222) Dempsey LA … Maizels N (Genomics 1998) 2 3 4 60
  3. Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. (PMID: 9521873) Wagner BJ … Brewer G (Genomics 1998) 3 4 22 60
  4. The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family. (PMID: 7673195) Kajita Y … Ishikawa F (The Journal of biological chemistry 1995) 3 4 22 60
  5. AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation. (PMID: 24423872) Lee KH … Kim KT (Nucleic acids research 2014) 3 4 60

Products for HNRNPD Gene

Sources for HNRNPD Gene

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