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HNRNPD Gene

protein-coding   GIFtS: 56
GCID: GC04M083274

Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element...

(Previous names: heterogeneous nuclear ribonucleoprotein D (AU-rich element...)
(Previous symbols: AUF1, HNRPD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding
Protein 1, 37kDa)1 2
     P372
AUF11 2 3 5     ARE-Binding Protein AUFI, Type A2
HNRPD1 2 3 5     Heterogeneous Nuclear Ribonucleoprotein D02
HnRNP D02 3     hnRNPD02
AUF1A2 5     AU-Rich Element RNA-Binding Protein 13
Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA-Binding
Protein 1, 37kD)1
     

External Ids:    HGNC: 50361   Entrez Gene: 31842   Ensembl: ENSG000001386687   OMIM: 6013245   UniProtKB: Q141033   

Export aliases for HNRNPD gene to outside databases

Previous GC identifers: GC04M083494 GC04M079015


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPD Gene:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These
proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other
aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to
shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.
The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the
nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing
of this gene results in four transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for HNRNPD Gene:
HNRNPD (heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)) is a protein-coding gene. Diseases associated with HNRNPD include metabolic acidosis, and rheumatic disease. GO annotations related to this gene include RNA binding and telomeric DNA binding. An important paralog of this gene is HNRNPA1.

UniProtKB/Swiss-Prot: HNRPD_HUMAN, Q14103
Function: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR
of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific
manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a
single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric
DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded
DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may
play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with
other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA
mediated by the major coding-region determinant of instability (mCRD) domain

Gene Wiki entry for HNRNPD (HNRPD) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPD gene promoter:
         AhR   STAT1   p53   STAT1beta   CUTL1   Nkx2-5   STAT1alpha   MZF-1   N-Myc   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRNPD promoter sequence
   Search Chromatin IP Primers for HNRNPD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.22   HGNC cytogenetic band: 4q21

HNRNPD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPD gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M083274:  view genomic region     (about GC identifiers)

Start:
83,273,651 bp from pter      End:
83,295,656 bp from pter
Size:
22,006 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HNRPD_HUMAN, Q14103 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein D0  
Size: 355 amino acids; 38434 Da
Subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Part of a complex
associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR and SYNCRIP. Interacts with
IGF2BP2. Interacts with GTPBP1
Sequence caution: Sequence=AAA35781.1; Type=Frameshift; Positions=45, 59, 355; Sequence=AAA35781.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
Sequence=CAA27544.1; Type=Miscellaneous discrepancy; Note=Several sequence conflicts;
6 PDB 3D structures from and Proteopedia for HNRNPD:
1HD0 (3D)        1HD1 (3D)        1IQT (3D)        1WTB (3D)        1X0F (3D)        2Z5N (3D)    
Secondary accessions: A8K9J2 P07029 Q01858 Q14100 Q14101 Q14102 Q4W5A1 Q9UCE8 Q9UCE9
Alternative splicing: 4 isoforms:  Q14103-1   Q14103-2   Q14103-3   Q14103-4   (Contains a N6-acetyllysine at position 273)

Explore the universe of human proteins at neXtProt for HNRNPD: NX_Q14103

Explore proteomics data for HNRNPD at MOPED

Post-translational modifications: 

  • Arg-345 is dimethylated, probably to asymmetric dimethylarginine1
  • Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates tyrosine
    phosphorylation (By similarity)1
  • Ubiquitination2 at Lys114, Lys119, Lys129, Lys183, Lys197, Lys231, Lys260
  • Modification sites at PhosphoSitePlus

  • See HNRNPD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001003810.1  NP_002129.2  NP_112737.1  NP_112738.1  

    ENSEMBL proteins: 
     ENSP00000313199   ENSP00000313327   ENSP00000426446   ENSP00000305860   ENSP00000424002  
     ENSP00000420926   ENSP00000421952   ENSP00000426666   ENSP00000422615   ENSP00000425439  
     ENSP00000439380   ENSP00000437416  
    Reactome Protein details: Q14103

    HNRNPD Human Recombinant Protein Products:

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    Novus Biologicals HNRNPD Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    HNRNPD Antibody Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012956 CARG-binding_factor_N
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q14103

    ProtoNet protein and cluster: Q14103

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: HNRPD_HUMAN, Q14103
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    HNRNPD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRPD_HUMAN, Q14103
    Function: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR
    of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific
    manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a
    single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric
    DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded
    DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may
    play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with
    other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA
    mediated by the major coding-region determinant of instability (mCRD) domain

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding NAS3754960
    GO:0005515protein binding IPI12107167
    GO:0042162telomeric DNA binding IDA8321232
         
    HNRNPD for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for HNRNPD:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased HPV18 LCR reporter a 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hnrnpd):
     cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     renal/urinary system 

    HNRNPD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hnrnpdtm1Rjsc for HNRNPD

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HNRNPD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HNRNPD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HNRNPD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HNRNPD

    miRNA
    Products:
        
    miRTarBase miRNAs that target HNRNPD:
    hsa-mir-221-3p (MIRT024179), hsa-mir-222-3p (MIRT046797), hsa-mir-1 (MIRT024012), hsa-mir-18a-3p (MIRT040890), hsa-mir-1229-3p (MIRT036291), hsa-mir-197-3p (MIRT004177)

    Block miRNA regulation of human, mouse, rat HNRNPD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPD (see all 45):
    hsa-miR-607 hsa-miR-300 hsa-miR-429 hsa-miR-146a hsa-miR-3653 hsa-miR-105 hsa-miR-1276 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPD 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HNRNPD
    Predesigned siRNA for gene silencing in human, mouse, rat HNRNPD

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): HNRNPD (NM_002138)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPD

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HNRPD_HUMAN, Q14103: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated
    mRNAs. Component of ribonucleosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS1433497
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0019013viral nucleocapsid ----

    HNRNPD for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPD About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2CDK-mediated phosphorylation and removal of Cdc6
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
    3Gene Expression
    Gene Expression0.40
    4Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HNRNPD
        Telomere Extension by Telomerase

    1 Cell Signaling Technology (CST) Pathway for HNRNPD
        Translational Control

    1 BioSystems Pathway for HNRNPD
        mRNA processing

    2 Reactome Pathways for HNRNPD
        mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA



    HNRNPD for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including HNRNPD: 
              Telomeres & Telomerase in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HNRNPD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPD (Q141031, 2, 3 ENSP000003131994) via UniProtKB, MINT, STRING, and/or I2D (see all 774)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ING4Q9UNL41, 2EBI-299674,EBI-2866661 MINT-8426536 MINT-8426567 MINT-8426585 MINT-8426209 MINT-8426481 MINT-8426514 MINT-8426558 MINT-8426218 MINT-8426398
    SYNCRIPO605061, 2, 3, ENSP000003586354EBI-432545,EBI-1024357 MINT-7945693 I2D: score=2 STRING: ENSP00000358635
    YBX1P678091, 3, ENSP000003616264EBI-432545,EBI-354065 I2D: score=2 STRING: ENSP00000361626
    ACTBP607092, 3, ENSP000003499604MINT-7945693 I2D: score=1 STRING: ENSP00000349960
    EIF4G1Q046371, 3, ENSP000003168794EBI-432545,EBI-73711 I2D: score=1 STRING: ENSP00000316879
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS1433497
    GO:0006396RNA processing TAS10205060
    GO:0006401RNA catabolic process TAS10205060

    HNRNPD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPD (HNRPD)

    5 Novoseek inferred chemical compound relationships for HNRNPD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 11 14 16834569 (5), 16556936 (2)
    oligonucleotide 0 1 16556936 (1)
    calcium 0 6 19397786 (3), 15514034 (1)
    tyrosine 0 1 16835382 (1)
    cyclosporin a 0 1 15514034 (1)



    HNRNPD for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HNRNPD gene (4 alternative transcripts): 
    NM_001003810.1  NM_002138.3  NM_031369.2  NM_031370.2  

    Unigene Cluster for HNRNPD:

    Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
    Hs.480073  [show with all ESTs]
    Unigene Representative Sequence: AL832723
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313899(uc003hml.1 uc003hmm.1 uc003hmn.1 uc003hmo.1 uc003hmp.1)
    ENST00000514325 ENST00000353341 ENST00000514671 ENST00000352301 ENST00000508119
    ENST00000513584 ENST00000509263 ENST00000507010 ENST00000515432 ENST00000503822
    ENST00000509107 ENST00000543098 ENST00000541060(uc010ijr.1 uc011cci.1)

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    Selected qRT-PCR Assays for microRNAs that regulate HNRNPD (see all 45):
    hsa-miR-607 hsa-miR-300 hsa-miR-429 hsa-miR-146a hsa-miR-3653 hsa-miR-105 hsa-miR-1276 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPD 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): HNRNPD (NM_002138)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPD
      QuantiFast Probe-based Assays in human, mouse, rat HNRNPD

    Additional mRNA sequence: 

    AF039575.1 AK057836.1 AK292707.1 AK300149.1 AK303552.1 AL832723.1 BC002401.1 BC023977.2 
    BC026015.2 D55671.1 D55672.1 D55673.1 D55674.1 M94630.1 X03910.1 

    Selected DOTS entries (see all 43):

    DT.100879404  DT.208467  DT.121220924  DT.319802  DT.100045012  DT.121220833  DT.100040642  DT.97865824 
    DT.99936726  DT.95320717  DT.100879402  DT.91999354  DT.100879396  DT.100879393  DT.100833653  DT.100742773 
    DT.91964585  DT.121220914  DT.100879391  DT.100879392  DT.121220729  DT.100879406  DT.121220717  DT.102845473 

    Selected AceView cDNA sequences (see all 577):

    BC026015 BQ632439 AI097281 BU687990 AA352838 BM845682 AI401011 AL698033 
    AW630571 AW467664 BU674161 BQ268311 D55671 AF039575 AA384719 AA764947 
    BM479016 BU685748 BM824146 BM468796 AI468190 BI850445 AW069308 CA426562 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPD (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b
    SP1:                    -           -           -     -                                               -     -     -     -               
    SP2:                    -           -           -     -                       -     -     -           -     -     -     -               
    SP3:                    -           -           -     -                       -     -     -                                             
    SP4:                    -     -     -           -     -                       -     -     -                                             
    SP5:                                                                          -     -     -           -     -                           


    ECgene alternative splicing isoforms for HNRNPD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPD expression in normal human tissues (normalized intensities)      HNRNPD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTAGTAGT
    HNRNPD Expression
    About this image


    HNRNPD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
    HNRNPD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.480073
        Pathway & Disease-focused RT2 Profiler PCR Array including HNRNPD: 
              Telomeres & Telomerase in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HNRNPD gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpd1 , 5 heterogeneous nuclear ribonucleoprotein D1, 5 93.99(n)1
    95.49(a)1
      5 (48.46 cM)5
    119911  NM_001077265.21  NP_001070733.11 
     999584265 
    chicken
    (Gallus gallus)
    Aves HNRNPD1 heterogeneous nuclear ribonucleoprotein D (AU-rich more 88.85(n)
    98.83(a)
      422602  NM_001031143.1  NP_001026314.1 
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPD6
    heterogeneous nuclear ribonucleoprotein D (AU-rich...
    95(a)
    1 ↔ 1
    5(42878058-42883441)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD301361.12   -- 81.35(n)    CD301361.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hnrnpd1 heterogeneous nuclear ribonucleoprotein D 74.91(n)
    86.91(a)
      560522  NM_001110460.1  NP_001103930.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sqd6
    squid
    35(a)
    1 → many
    3R(9460679-9472026)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRP16
    Subunit of cleavage factor I, a five-subunit compl...
    22(a)
    1 → many
    XV(87844-89448) YOL123W


    ENSEMBL Gene Tree for HNRNPD (if available)
    TreeFam Gene Tree for HNRNPD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPD gene
    HNRNPA12  HNRNPDL2  HNRNPA32  HNRNPA02  HNRNPAB2  HNRNPA1L22  HNRNPA2B12  
    Selected SIMAP similar genes for HNRNPD using alignment to 10 protein entries:     HNRPD_HUMAN (see all proteins) (see all similar genes):
    HNRNPDL    HNRNPAB    NOL8    HNRNPA2B1    BOLL    G3BP1
    RBMY1E    HNRNPA1    CIRBP    HNRPA1    SLIRP    MSI2
    CSTF2    HNRNPA3    HNRPA3    HNRNPA1L2    DAZAP1    TARDBP

    HNRNPD for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HNRNPD
    PGOHUM00000243232 PGOHUM00000241809


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPD (see all 470)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1909800031,2
    --83089649(+) GGAGGC/TCAAAT 4 -- ds50010--------
    rs1826333101,2
    --83089670(+) AGATGC/TAACTC 4 -- ds50010--------
    rs1150602011,2
    F--83089734(+) ATACAT/GTTCTC 4 -- ds50011Minor allele frequency- G:0.03WA 118
    rs757845691,2
    C,F--83089765(+) ACTATT/CCTGAG 4 -- ds50011Minor allele frequency- C:0.07WA 118
    rs1445969711,2
    --83089806(+) GATTAA/CCACTC 4 -- ds50010--------
    rs76911211,2
    C,F,A--83089853(+) ACAAAC/GGATTT 4 -- ds500114Minor allele frequency- G:0.33NA EA WA CSA 691
    rs1484837761,2
    C--83089883(+) ATCAAC/TTCCCT 4 -- ds50010--------
    rs744601431,2
    F--83089906(+) CAGAAC/TTCAAG 4 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1500553361,2
    C--83089968(+) CACTT-/AAGACT 4 -- ds50010--------
    rs783851721,2
    C,F--83090132(+) AACACG/AGTATA 4 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for HNRNPD (83273651 - 83295656 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HNRNPD:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829988CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPD
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601324    OMIM disorders: --

    Selected diseases for HNRNPD (see all 24):    About MalaCards
    metabolic acidosis    rheumatic disease    hyperparathyroidism    oral squamous cell carcinoma
    hepatitis c virus    hepatitis    hepatitis c    tonsillitis
    squamous cell carcinoma    hepatitis b    hiv-1    thyroiditis
    hepatocellular carcinoma    melanoma    multiple myeloma    neuroblastoma
    myeloma    breast cancer    endotheliitis    pancreatitis


    HNRNPD for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for HNRNPD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 18.2 7 12356764 (2), 16556936 (2), 10205060 (1)
    necrosis 7.61 2 18240226 (1), 11124962 (1)
    tumors 0 4 19574297 (1), 14585195 (1), 18240226 (1), 11124962 (1)
    heart failure 0 1 8626551 (1)

    Genetic Association Database (GAD): HNRNPD

    Export disorders for HNRNPD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPD gene, integrated from 10 sources (see all 220):
    (articles sorted by number of sources associating them with HNRNPD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human HNRPD locus maps to 4q21 and encodes a highly conserved protein. (PubMed id 9615222)1, 2, 3 Dempsey L.A.... Maizels N. (Genomics 1998)
    2. Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. (PubMed id 9521873)1, 2, 9 Wagner B.J.... Brewer G. (Genomics 1998)
    3. Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0. (PubMed id 10080887)1, 2, 9 Nagata T.... Katahira M. (J. Mol. Biol. 1999)
    4. The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family. (PubMed id 7673195)1, 2, 9 Kajita Y.... Ishikawa F. (J. Biol. Chem. 1995)
    5. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    8. Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)1, 2 Ong S.E.... Mann M. (Nat. Methods 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D). (PubMed id 12674497)1, 2 Moraes K.C.... Kobarg J. (Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3184 HGNC: 5036 AceView: HNRPD Ensembl:ENSG00000138668 euGenes: HUgn3184
    ECgene: HNRNPD H-InvDB: HNRNPD

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HNRNPD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HNRNPD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPD gene:
    Search GeneIP for patents involving HNRNPD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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