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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNRNPD Gene

protein-coding   GIFtS: 57
GCID: GC04M083274

Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element...

(Previous names: heterogeneous nuclear ribonucleoprotein D (AU-rich element...)
(Previous symbols: AUF1, HNRPD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding
Protein 1, 37kDa)1 2
     P372
AUF11 2 3 5     ARE-Binding Protein AUFI, Type A2
HNRPD1 2 3 5     Heterogeneous Nuclear Ribonucleoprotein D02
HnRNP D02 3     hnRNPD02
AUF1A2 5     AU-Rich Element RNA-Binding Protein 13
Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA-Binding
Protein 1, 37kD)1
     

External Ids:    HGNC: 50361   Entrez Gene: 31842   Ensembl: ENSG000001386687   OMIM: 6013245   UniProtKB: Q141033   

Export aliases for HNRNPD gene to outside databases

Previous GC identifers: GC04M083494 GC04M079015


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HNRNPD Gene:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These
proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other
aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to
shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.
The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the
nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing
of this gene results in four transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for HNRNPD Gene: 
HNRNPD (heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)) is a protein-coding gene. Diseases associated with HNRNPD include metabolic acidosis, and hyperparathyroidism, and among its related super-pathways are mRNA Processing and Metabolism of RNA. GO annotations related to this gene include RNA binding and telomeric DNA binding. An important paralog of this gene is HNRNPDL.

UniProtKB/Swiss-Prot: HNRPD_HUMAN, Q14103
Function: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR
of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific
manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a
single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric
DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded
DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may
play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with
other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA
mediated by the major coding-region determinant of instability (mCRD) domain

Gene Wiki entry for HNRNPD (HNRPD) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNRNPD gene promoter:
         AhR   STAT1   p53   STAT1beta   CUTL1   Nkx2-5   STAT1alpha   MZF-1   N-Myc   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRNPD promoter sequence
   Search SABiosciences Chromatin IP Primers for HNRNPD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.22   HGNC cytogenetic band: 4q21

HNRNPD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPD gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M083274:  view genomic region     (about GC identifiers)

Start:
83,273,651 bp from pter      End:
83,295,656 bp from pter
Size:
22,006 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HNRPD_HUMAN, Q14103 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein D0  
Size: 355 amino acids; 38434 Da
Subunit: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1,
HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1,
RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Part of a complex associated
with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR and SYNCRIP. Interacts with IGF2BP2.
Interacts with GTPBP1
Subcellular location: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated
mRNAs. Component of ribonucleosomes
Sequence caution: Sequence=AAA35781.1; Type=Frameshift; Positions=45, 59, 355; Sequence=AAA35781.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
Sequence=CAA27544.1; Type=Miscellaneous discrepancy; Note=Several sequence conflicts;
6 PDB 3D structures from and Proteopedia for HNRNPD:
1HD0 (3D)        1HD1 (3D)        1IQT (3D)        1WTB (3D)        1X0F (3D)        2Z5N (3D)    
Secondary accessions: A8K9J2 P07029 Q01858 Q14100 Q14101 Q14102 Q4W5A1 Q9UCE8 Q9UCE9
Alternative splicing: 4 isoforms:  Q14103-1   Q14103-2   Q14103-3   Q14103-4   (Contains a N6-acetyllysine at position 273)

Explore the universe of human proteins at neXtProt for HNRNPD: NX_Q14103

Explore proteomics data for HNRNPD at MOPED 

Post-translational modifications:

  • UniProtKB: Arg-345 is dimethylated, probably to asymmetric dimethylarginine
  • UniProtKB: Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates tyrosine
    phosphorylation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14103

  • HNRNPD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HNRNPD Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001003810.1  NP_002129.2  NP_112737.1  NP_112738.1  

    ENSEMBL proteins: 
     ENSP00000313199   ENSP00000313327   ENSP00000426446   ENSP00000305860   ENSP00000424002  
     ENSP00000420926   ENSP00000421952   ENSP00000426666   ENSP00000422615   ENSP00000425439  
     ENSP00000439380   ENSP00000437416  
    Reactome Protein details: Q14103
    Human Recombinant Protein Products for HNRNPD: 
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    Novus Biologicals HNRNPD Protein
    Novus Biologicals HNRNPD Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS1433497
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0030529ribonucleoprotein complex IDA17289661

    HNRNPD for ontologies           About GeneDecksing



    HNRNPD Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012956 CARG-binding_factor_N
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q14103

    ProtoNet protein and cluster: Q14103

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: HNRPD_HUMAN, Q14103
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    HNRNPD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRPD_HUMAN, Q14103
    Function: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR
    of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific
    manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a
    single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric
    DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded
    DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may
    play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with
    other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA
    mediated by the major coding-region determinant of instability (mCRD) domain

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding NAS3754960
    GO:0005515protein binding IPI12107167
    GO:0042162telomeric DNA binding IDA8321232
         
    HNRNPD for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for HNRNPD:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased HPV18 LCR reporter a 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hnrnpd):
     cardiovascular system  growth/size  homeostasis/metabolism  immune system  renal/urinary system 

    HNRNPD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hnrnpdtm1Rjsc for HNRNPD

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HNRNPD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HNRNPD

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    miRNA
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    miRTarBase miRNAs that target HNRNPD:
    hsa-mir-197 (MIRT004177)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HNRNPD
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRNPD (see all 45):
    hsa-miR-607 hsa-miR-300 hsa-miR-429 hsa-miR-146a hsa-miR-3653 hsa-miR-105 hsa-miR-1276 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPD 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HNRNPD About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA processing0.46
    mRNA Splicing - Major Pathway0.82
    2Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    3CDK-mediated phosphorylation and removal of Cdc6
    Destabilization of mRNA by AUF1 (hnRNP D0)0.87
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.63
    4Generic Transcription Pathway
    Gene Expression0.47
    5Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HNRNPD
        Translational Control

    1 BioSystems Pathway for HNRNPD
        mRNA processing

    5/9        Reactome Pathways for HNRNPD (see all 9)
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    mRNA Splicing - Major Pathway
    mRNA Splicing
    Destabilization of mRNA by AUF1 (hnRNP D0)
    Metabolism of RNA



    HNRNPD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HNRNPD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/740 Interacting proteins for HNRNPD (Q141031, 2, 3 ENSP000003131994) via UniProtKB, MINT, STRING, and/or I2D (see all 740)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYNCRIPO605061, 2, 3, ENSP000003586354EBI-432545,EBI-1024357 MINT-7945693 I2D: score=2 STRING: ENSP00000358635
    YBX1P678091, 3, ENSP000003616264EBI-432545,EBI-354065 I2D: score=2 STRING: ENSP00000361626
    ACTBP607092, 3, ENSP000003499604MINT-7945693 I2D: score=1 STRING: ENSP00000349960
    EIF4G1Q046371, 3, ENSP000003168794EBI-432545,EBI-73711 I2D: score=1 STRING: ENSP00000316879
    HDAC1Q135472, 3, ENSP000003626494MINT-7945693 I2D: score=1 STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS1433497
    GO:0006396RNA processing TAS10205060
    GO:0006401RNA catabolic process TAS10205060

    HNRNPD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HNRNPD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HNRNPD (HNRPD)

    5 Novoseek inferred chemical compound relationships for HNRNPD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 11 14 16834569 (5), 16556936 (2)
    oligonucleotide 0 1 16556936 (1)
    calcium 0 6 19397786 (3), 15514034 (1)
    tyrosine 0 1 16835382 (1)
    cyclosporin a 0 1 15514034 (1)

    Search CenterWatch for drugs/clinical trials and news about HNRNPD / HNRPD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HNRNPD gene (4 alternative transcripts): 
    NM_001003810.1  NM_002138.3  NM_031369.2  NM_031370.2  

    Unigene Cluster for HNRNPD:

    Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
    Hs.480073  [show with all ESTs]
    Unigene Representative Sequence: AL832723
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313899(uc003hml.1 uc003hmm.1 uc003hmn.1 uc003hmo.1 uc003hmp.1)
    ENST00000514325 ENST00000353341 ENST00000514671 ENST00000352301 ENST00000508119
    ENST00000513584 ENST00000509263 ENST00000507010 ENST00000515432 ENST00000503822
    ENST00000509107 ENST00000543098 ENST00000541060(uc010ijr.1 uc011cci.1)

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    Additional mRNA sequence: 

    AF039575.1 AK057836.1 AK292707.1 AK300149.1 AK303552.1 AL832723.1 BC002401.1 BC023977.2 
    BC026015.2 D55671.1 D55672.1 D55673.1 D55674.1 M94630.1 X03910.1 

    24/43 DOTS entries (see all 43):

    DT.100879404  DT.208467  DT.121220924  DT.319802  DT.100045012  DT.121220833  DT.100040642  DT.97865824 
    DT.99936726  DT.95320717  DT.100879402  DT.91999354  DT.100879396  DT.100879393  DT.100833653  DT.100742773 
    DT.91964585  DT.121220914  DT.100879391  DT.100879392  DT.121220729  DT.100879406  DT.121220717  DT.102845473 

    24/577 AceView cDNA sequences (see all 577):

    AI629015 BG292440 BC002401 AA304460 BU633921 BU902276 AW467664 BU674161 
    AL698033 AI401011 CB158168 BU727499 AW069308 BC026015 BQ632439 AI097281 
    BU687990 AA352838 BM845682 AA384877 CR621925 AU077201 T29055 CB070296 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPD (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b
    SP1:                    -           -           -     -                                               -     -     -     -               
    SP2:                    -           -           -     -                       -     -     -           -     -     -     -               
    SP3:                    -           -           -     -                       -     -     -                                             
    SP4:                    -     -     -           -     -                       -     -     -                                             
    SP5:                                                                          -     -     -           -     -                           


    ECgene alternative splicing isoforms for HNRNPD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNRNPD expression in normal human tissues (normalized intensities)      HNRNPD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTAGTAGT
    HNRNPD Expression
    About this image


    HNRNPD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   

    See HNRNPD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNRNPD

    SOURCE GeneReport for Unigene cluster: Hs.480073
        SABiosciences Expression via Pathway-Focused PCR Array including HNRNPD: 
              Telomeres & Telomerase in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HNRNPD gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpd1 , 5 heterogeneous nuclear ribonucleoprotein D1, 5 95.2(n)1
    97.74(a)1
      5 (48.46 cM)5
    119911  NM_001077265.11  NP_001070733.11 
     999584265 
    chicken
    (Gallus gallus)
    Aves HNRNPD1 heterogeneous nuclear ribonucleoprotein D (AU-rich more 88.85(n)
    98.83(a)
      422602  NM_001031143.1  NP_001026314.1 
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPD6
    Uncharacterized protein
    95(a)
    1 ↔ 1
    5(42878058-42883441)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD301361.12   -- 81.35(n)    CD301361.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hnrnpd1 heterogeneous nuclear ribonucleoprotein D 74.8(n)
    87.11(a)
      560522  NM_001110460.1  NP_001103930.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0003991 AGAP000399-PB 50.75(n)
    41.79(a)
      1271847  XM_310701.4  XP_310701.4 
    worm
    (Caenorhabditis elegans)
    Secernentea sqd-11 Protein SQD-1 46.49(n)
    35.34(a)
      177392  NM_001028403.2  NP_001023574.1 


    ENSEMBL Gene Tree for HNRNPD (if available)
    TreeFam Gene Tree for HNRNPD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HNRNPD gene
    HNRNPDL2  HNRNPA12  HNRNPA02  HNRNPA32  HNRNPAB2  DAZAP12  HNRNPA1L22  HNRNPA2B12  
    18/35 SIMAP similar genes for HNRNPD using alignment to 10 protein entries:     HNRPD_HUMAN (see all proteins) (see all similar genes):
    HNRPDL    HNRNPAB    NOL8    HNRNPA2B1    BOLL    G3BP1
    RBMY1E    HNRNPA1    CIRBP    HNRPA1    SLIRP    MSI2
    CSTF2    HNRNPA3    HNRPA3    HNRNPA1L2    TARDBP    DAZAP1

    HNRNPD for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HNRNPD
    PGOHUM00000243232 PGOHUM00000241809


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/470 SNPs in HNRNPD are shown (see all 470)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1909800031,2
    --83089649(+) GGAGGC/TCAAAT 4 -- ds50010--------
    rs1826333101,2
    --83089670(+) AGATGC/TAACTC 4 -- ds50010--------
    rs1150602011,2
    F--83089734(+) ATACAT/GTTCTC 4 -- ds50011Minor allele frequency- G:0.03WA 118
    rs757845691,2
    C,F--83089765(+) ACTATT/CCTGAG 4 -- ds50011Minor allele frequency- C:0.07WA 118
    rs1445969711,2
    --83089806(+) GATTAA/CCACTC 4 -- ds50010--------
    rs76911211,2
    C,F,A--83089853(+) ACAAAC/GGATTT 4 -- ds500114Minor allele frequency- G:0.33NA EA WA CSA 691
    rs1484837761,2
    C--83089883(+) ATCAAC/TTCCCT 4 -- ds50010--------
    rs744601431,2
    F--83089906(+) CAGAAC/TTCAAG 4 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1500553361,2
    C--83089968(+) CACTT-/AAGACT 4 -- ds50010--------
    rs783851721,2
    C,F--83090132(+) AACACG/AGTATA 4 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for HNRNPD (83273651 - 83295656 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HNRNPD:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829988CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601324    OMIM disorders: --

    15 diseases for HNRNPD:    About MalaCards
    metabolic acidosis    hyperparathyroidism    rheumatic disease    oral squamous cell carcinoma
    hepatitis    hepatitis c    squamous cell carcinoma    thyroiditis
    hepatitis b    hepatocellular carcinoma    melanoma    gastric cancer
    endotheliitis    breast cancer    neuronitis


    HNRNPD for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for HNRNPD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 18.2 7 12356764 (2), 16556936 (2), 10205060 (1)
    necrosis 7.61 2 18240226 (1), 11124962 (1)
    tumors 0 4 19574297 (1), 14585195 (1), 18240226 (1), 11124962 (1)
    heart failure 0 1 8626551 (1)

    Genetic Association Database (GAD): HNRNPD

    Export disorders for HNRNPD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNRNPD gene, integrated from 9 sources (see all 218):
    (articles sorted by number of sources associating them with HNRNPD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human HNRPD locus maps to 4q21 and encodes a highly conserved protein. (PubMed id 9615222)1, 2, 3 Dempsey L.A.... Maizels N. (1998)
    2. Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. (PubMed id 9521873)1, 2, 9 Wagner B.J.... Brewer G. (1998)
    3. Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0. (PubMed id 10080887)1, 2, 9 Nagata T.... Katahira M. (1999)
    4. The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family. (PubMed id 7673195)1, 2, 9 Kajita Y.... Ishikawa F. (1995)
    5. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    8. Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)1, 2 Ong S.E.... Mann M. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D). (PubMed id 12674497)1, 2 Moraes K.C.... Kobarg J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3184 HGNC: 5036 AceView: HNRPD Ensembl:ENSG00000138668 euGenes: HUgn3184
    ECgene: HNRNPD H-InvDB: HNRNPD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNRNPD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HNRNPD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HNRNPD gene:
    Search GeneIP for patents involving HNRNPD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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