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Aliases for HNRNPCL1 Gene

Aliases for HNRNPCL1 Gene

  • Heterogeneous Nuclear Ribonucleoprotein C-Like 1 2 3
  • HnRNP Core Protein C-Like 1 3 4
  • HnRNP C-Like-1 3 4
  • HNRPCL1 3 4

External Ids for HNRNPCL1 Gene

Previous HGNC Symbols for HNRNPCL1 Gene

  • HNRPCL1

Previous GeneCards Identifiers for HNRNPCL1 Gene

  • GC01M012830
  • GC01M012907
  • GC01M012060

Summaries for HNRNPCL1 Gene

GeneCards Summary for HNRNPCL1 Gene

HNRNPCL1 (Heterogeneous Nuclear Ribonucleoprotein C-Like 1) is a Protein Coding gene. Diseases associated with HNRNPCL1 include pancreatic endocrine carcinoma. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RALYL.

UniProtKB/Swiss-Prot for HNRNPCL1 Gene

  • May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPCL1 Gene

Genomics for HNRNPCL1 Gene

Regulatory Elements for HNRNPCL1 Gene

Genomic Location for HNRNPCL1 Gene

Start:
12,847,377 bp from pter
End:
12,947,578 bp from pter
Size:
100,202 bases
Orientation:
Minus strand

Genomic View for HNRNPCL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPCL1 Gene

Proteins for HNRNPCL1 Gene

  • Protein details for HNRNPCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60812-HNRC1_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein C-like 1
    Protein Accession:
    O60812
    Secondary Accessions:
    • B2RP44

    Protein attributes for HNRNPCL1 Gene

    Size:
    293 amino acids
    Molecular mass:
    32142 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HNRNPCL1 Gene

Proteomics data for HNRNPCL1 Gene at MOPED

Post-translational modifications for HNRNPCL1 Gene

  • Ubiquitination at Lys29, Lys39, and Lys193
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPCL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPCL1 Gene

Domains for HNRNPCL1 Gene

Gene Families for HNRNPCL1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for HNRNPCL1 Gene

Suggested Antigen Peptide Sequences for HNRNPCL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60812

UniProtKB/Swiss-Prot:

HNRC1_HUMAN :
  • O60812
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RRM HNRPC family. RALY subfamily.
genes like me logo Genes that share domains with HNRNPCL1: view

Function for HNRNPCL1 Gene

Molecular function for HNRNPCL1 Gene

UniProtKB/Swiss-Prot Function: May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.

Gene Ontology (GO) - Molecular Function for HNRNPCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with HNRNPCL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HNRNPCL1 TF2648 - C2

CRISPR Products

miRNA for HNRNPCL1 Gene

miRTarBase miRNAs that target HNRNPCL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPCL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPCL1 Gene

Localization for HNRNPCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPCL1 Gene

Nucleus. Note=Component of ribonucleosomes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPCL1 Gene COMPARTMENTS Subcellular localization image for HNRNPCL1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for HNRNPCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with HNRNPCL1: view

Pathways for HNRNPCL1 Gene

SuperPathways for HNRNPCL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HNRNPCL1 Gene

None

No data available for Pathways by source for HNRNPCL1 Gene

Transcripts for HNRNPCL1 Gene

mRNA/cDNA for HNRNPCL1 Gene

(4) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HNRNPCL1 Gene

Heterogeneous nuclear ribonucleoprotein C-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPCL1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HNRNPCL1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPCL1 Gene

No ASD Table

Relevant External Links for HNRNPCL1 Gene

GeneLoc Exon Structure for
HNRNPCL1
ECgene alternative splicing isoforms for
HNRNPCL1

Expression for HNRNPCL1 Gene

mRNA expression in normal human tissues for HNRNPCL1 Gene

mRNA differential expression in normal tissues according to GTEx for HNRNPCL1 Gene

This gene is overexpressed in Testis (40.0), Brain - Cortex (6.5), and Cervix - Ectocervix (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPCL1 Gene

SOURCE GeneReport for Unigene cluster for HNRNPCL1 Gene Hs.502617

genes like me logo Genes that share expressions with HNRNPCL1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HNRNPCL1 Gene

Orthologs for HNRNPCL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPCL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
cow
(Bos Taurus)
Mammalia HNRPC 36
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 75 (a)
ManyToMany
-- 36
  • 89 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hnrnpc 36
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hnrnpc 36
  • 54 (a)
ManyToMany
zgc:55733 36
  • 60 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42458 36
  • 12 (a)
OneToMany
Species with no ortholog for HNRNPCL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPCL1 Gene

ENSEMBL:
Gene Tree for HNRNPCL1 (if available)
TreeFam:
Gene Tree for HNRNPCL1 (if available)

Paralogs for HNRNPCL1 Gene

Paralogs for HNRNPCL1 Gene

Selected SIMAP similar genes for HNRNPCL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HNRNPCL1: view

Variants for HNRNPCL1 Gene

Sequence variations from dbSNP and Humsavar for HNRNPCL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1736808 -- 12,848,390(-) GTCAG(C/T)TTCTC utr-variant-5-prime
rs1736809 -- 12,848,383(-) TCTCC(A/C)CGTAG utr-variant-5-prime
rs1736811 -- 12,847,984(-) GCAGC(A/G)GAGAT synonymous-codon, reference
rs1856637 -- 12,850,088(+) CCAGC(A/C)CCTTG upstream-variant-2KB
rs1856638 -- 12,850,283(+) AAATC(A/G)TGTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HNRNPCL1 Gene

Variant ID Type Subtype PubMed ID
dgv20e1 CNV Complex 17122850
dgv21e1 CNV Complex 17122850
nsv428410 CNV Gain+Loss 18775914
nsv466394 CNV Gain 19166990
essv3598 CNV CNV 17122850
dgv22e1 CNV Complex 17122850
dgv146n71 CNV Gain 21882294
nsv832869 CNV Gain+Loss 17160897
dgv23e1 CNV Complex 17122850
nsv470695 CNV Loss 18288195
nsv528703 CNV Loss 19592680
dgv24e1 CNV Complex 17122850
dgv147n71 CNV Gain 21882294
dgv5n27 CNV Gain 19166990
dgv6n27 CNV Loss 19166990
dgv149n71 CNV Gain 21882294
nsv517190 CNV Gain+Loss 19592680
dgv13n67 CNV Loss 20364138
esv28644 CNV Gain+Loss 19812545
esv990214 CNV Gain 20482838
esv2421662 OTHER Complex 20811451
nsv8768 CNV Gain+Loss 18304495
dgv14n67 CNV Gain 20364138
esv32750 CNV Gain 17666407
dgv151n71 CNV Loss 21882294
dgv155n71 CNV Gain+Loss 21882294
dgv156n71 CNV Gain 21882294
dgv157n71 CNV Gain+Loss 21882294
dgv158n71 CNV Gain 21882294
nsv871956 CNV Loss 21882294
dgv159n71 CNV Loss 21882294
esv2669351 CNV Deletion 23128226
dgv25e1 CNV Complex 17122850
nsv470696 CNV Gain 18288195
dgv8n27 CNV Loss 19166990
dgv9n27 CNV Gain 19166990
nsv817728 CNV Gain+Loss 17921354
dgv1n64 CNV Loss 17921354
nsv871633 CNV Gain 21882294
dgv161n71 CNV Loss 21882294
nsv2965 CNV Loss 18451855
esv2743853 CNV Deletion 23290073
nsv871161 CNV Gain+Loss 21882294
nsv7172 OTHER Inversion 18451855
nsv460350 CNV Loss 19166990
nsv433182 CNV Loss 18776910
nsv871065 CNV Gain 21882294
dgv162n71 CNV Loss 21882294
dgv16e201 CNV Deletion 23290073
esv2743875 CNV Deletion 23290073
nsv870584 CNV Gain+Loss 21882294
nsv820528 CNV Deletion 20802225
nsv436469 CNV Deletion 17901297
dgv17e201 CNV Deletion 23290073
dgv16n67 CNV Gain 20364138
esv2678231 CNV Deletion 23128226
nsv819147 CNV Gain 19587683
nsv821616 CNV Gain 15273396
esv2743920 CNV Deletion 23290073
esv2675529 CNV Deletion 23128226

Relevant External Links for HNRNPCL1 Gene

HapMap Linkage Disequilibrium report
HNRNPCL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPCL1 Gene

Disorders for HNRNPCL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HNRNPCL1 Gene including...

Search for HNRNPCL1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for HNRNPCL1 Gene

genes like me logo Genes that share disorders with HNRNPCL1: view

No data available for UniProtKB/Swiss-Prot for HNRNPCL1 Gene

Publications for HNRNPCL1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry. (PMID: 18457437) Forsman A. … Rymo L. (J. Proteome Res. 2008) 3
  3. System-wide changes to SUMO modifications in response to heat shock. (PMID: 19471022) Golebiowski F. … Hay R.T. (Sci Signal 2009) 3
  4. Identification of DeltaNp63alpha protein interactions by mass spectrometry. (PMID: 20085233) Amoresano A. … CalabrA^ V. (J. Proteome Res. 2010) 3
  5. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PMID: 21110914) Grant M.M. (BMB Rep 2010) 3

Products for HNRNPCL1 Gene

Sources for HNRNPCL1 Gene

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