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Aliases for HNRNPCL1 Gene

Aliases for HNRNPCL1 Gene

  • Heterogeneous Nuclear Ribonucleoprotein C-Like 1 2 3 5
  • HnRNP Core Protein C-Like 1 3 4
  • HnRNP C-Like-1 3 4
  • HNRPCL1 3 4

External Ids for HNRNPCL1 Gene

Previous HGNC Symbols for HNRNPCL1 Gene


Previous GeneCards Identifiers for HNRNPCL1 Gene

  • GC01M012830
  • GC01M012907
  • GC01M012060

Summaries for HNRNPCL1 Gene

GeneCards Summary for HNRNPCL1 Gene

HNRNPCL1 (Heterogeneous Nuclear Ribonucleoprotein C-Like 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is HNRNPCL2.

UniProtKB/Swiss-Prot for HNRNPCL1 Gene

  • May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPCL1 Gene

Genomics for HNRNPCL1 Gene

Regulatory Elements for HNRNPCL1 Gene

Genomic Location for HNRNPCL1 Gene

12,847,377 bp from pter
12,848,756 bp from pter
1,380 bases
Minus strand

Genomic View for HNRNPCL1 Gene

Genes around HNRNPCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPCL1 Gene

Proteins for HNRNPCL1 Gene

  • Protein details for HNRNPCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein C-like 1
    Protein Accession:
    Secondary Accessions:
    • B2RP44

    Protein attributes for HNRNPCL1 Gene

    293 amino acids
    Molecular mass:
    32142 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HNRNPCL1 Gene

Post-translational modifications for HNRNPCL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HNRNPCL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPCL1 Gene

Domains & Families for HNRNPCL1 Gene

Gene Families for HNRNPCL1 Gene

Protein Domains for HNRNPCL1 Gene

Suggested Antigen Peptide Sequences for HNRNPCL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRM HNRPC family. RALY subfamily.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRM HNRPC family. RALY subfamily.
genes like me logo Genes that share domains with HNRNPCL1: view

Function for HNRNPCL1 Gene

Molecular function for HNRNPCL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.

Gene Ontology (GO) - Molecular Function for HNRNPCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with HNRNPCL1: view
genes like me logo Genes that share phenotypes with HNRNPCL1: view

Animal Model Products

CRISPR Products

miRNA for HNRNPCL1 Gene

miRTarBase miRNAs that target HNRNPCL1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPCL1 Gene

Localization for HNRNPCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPCL1 Gene

Nucleus. Note=Component of ribonucleosomes. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for HNRNPCL1 Gene COMPARTMENTS Subcellular localization image for HNRNPCL1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HNRNPCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with HNRNPCL1: view

Pathways & Interactions for HNRNPCL1 Gene

SuperPathways for HNRNPCL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HNRNPCL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for HNRNPCL1 Gene

Drugs & Compounds for HNRNPCL1 Gene

No Compound Related Data Available

Transcripts for HNRNPCL1 Gene


(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HNRNPCL1 Gene

Heterogeneous nuclear ribonucleoprotein C-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPCL1 Gene

No ASD Table

Relevant External Links for HNRNPCL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HNRNPCL1 Gene

mRNA expression in normal human tissues for HNRNPCL1 Gene

mRNA differential expression in normal tissues according to GTEx for HNRNPCL1 Gene

This gene is overexpressed in Testis (x40.0), Brain - Cortex (x6.5), and Cervix - Ectocervix (x6.4).

Protein differential expression in normal tissues from HIPED for HNRNPCL1 Gene

This gene is overexpressed in Blymphocyte (11.6), Nasal epithelium (10.0), Tlymphocyte (9.9), Monocytes (9.0), Liver, secretome (7.8), and Breast (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPCL1 Gene

Protein tissue co-expression partners for HNRNPCL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HNRNPCL1 Gene:


SOURCE GeneReport for Unigene cluster for HNRNPCL1 Gene:

genes like me logo Genes that share expression patterns with HNRNPCL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HNRNPCL1 Gene

Orthologs for HNRNPCL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPCL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HNRPC 35
  • 90 (a)
(Canis familiaris)
Mammalia -- 35
  • 75 (a)
-- 35
  • 89 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 76 (a)
(Mus musculus)
Mammalia Hnrnpc 35
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 90 (a)
(Pan troglodytes)
Mammalia -- 35
  • 95 (a)
-- 35
  • 96 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 79 (a)
(Danio rerio)
Actinopterygii hnrnpc 35
  • 54 (a)
zgc:55733 35
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42458 35
  • 12 (a)
Species where no ortholog for HNRNPCL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPCL1 Gene

Gene Tree for HNRNPCL1 (if available)
Gene Tree for HNRNPCL1 (if available)

Paralogs for HNRNPCL1 Gene

Paralogs for HNRNPCL1 Gene

(7) SIMAP similar genes for HNRNPCL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HNRNPCL1: view

Variants for HNRNPCL1 Gene

Sequence variations from dbSNP and Humsavar for HNRNPCL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2076063 - 12,847,517(-) TGATG(A/T)TAATG reference, missense
rs6702447 - 12,847,666(+) TTGCT(A/C)TGTTC reference, missense
rs2982092 - 12,848,048(-) TGTAG(A/G/T)TATTA reference, missense
rs848418 -- 12,848,032(-) GCTGC(A/G)GAGCC reference, synonymous-codon
rs1736808 -- 12,848,390(-) GTCAG(C/T)TTCTC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HNRNPCL1 Gene

Variant ID Type Subtype PubMed ID
dgv114n54 CNV gain 21841781
dgv116n54 CNV loss 21841781
dgv117n54 CNV gain+loss 21841781
dgv120n54 CNV loss 21841781
dgv123n54 CNV gain+loss 21841781
dgv124n54 CNV loss 21841781
dgv125n54 CNV loss 21841781
dgv127n54 CNV loss 21841781
dgv129n54 CNV loss 21841781
dgv130n54 CNV loss 21841781
dgv131n54 CNV loss 21841781
dgv13n67 CNV loss 20364138
dgv14n67 CNV gain 20364138
dgv16n67 CNV gain 20364138
dgv1n64 CNV loss 17921354
dgv20n100 CNV loss 25217958
dgv21n100 CNV loss 25217958
dgv27n100 CNV gain+loss 25217958
dgv28n100 CNV gain+loss 25217958
dgv33n100 CNV loss 25217958
dgv5n27 CNV gain 19166990
dgv6e201 CNV deletion 23290073
dgv6e214 CNV loss 21293372
dgv6n111 CNV duplication 26073780
dgv6n27 CNV loss 19166990
dgv7e214 CNV gain 21293372
dgv7n111 CNV deletion 26073780
dgv8n27 CNV loss 19166990
dgv9n27 CNV gain 19166990
esv2421662 OTHER complex 20811451
esv2669351 CNV deletion 23128226
esv2678231 CNV deletion 23128226
esv2743853 CNV deletion 23290073
esv2743875 CNV deletion 23290073
esv2743920 CNV deletion 23290073
esv28644 CNV gain+loss 19812545
esv32750 CNV gain 17666407
esv3585241 CNV loss 21293372
esv3585246 CNV loss 21293372
esv3585247 CNV loss 21293372
esv3891192 CNV gain+loss 25118596
esv3891414 CNV gain+loss 25118596
esv3891748 CNV gain+loss 25118596
esv990214 CNV gain 20482838
nsv1002419 CNV gain 25217958
nsv1010920 CNV gain+loss 25217958
nsv1075770 CNV duplication 25765185
nsv1161105 CNV deletion 26073780
nsv1161161 CNV deletion 26073780
nsv1161165 CNV duplication 26073780
nsv2965 CNV deletion 18451855
nsv433182 CNV loss 18776910
nsv436469 CNV deletion 17901297
nsv460350 CNV loss 19166990
nsv466394 CNV gain 19166990
nsv470695 CNV loss 18288195
nsv470696 CNV gain 18288195
nsv528703 CNV loss 19592680
nsv545445 CNV gain 21841781
nsv545457 CNV loss 21841781
nsv545462 CNV gain 21841781
nsv7172 OTHER inversion 18451855
nsv817728 CNV gain+loss 17921354
nsv820528 CNV deletion 20802225
nsv832869 CNV gain+loss 17160897
nsv8768 CNV gain+loss 18304495
nsv945774 CNV duplication 23825009
nsv999194 CNV gain 25217958

Variation tolerance for HNRNPCL1 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.66; 86.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPCL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPCL1 Gene

Disorders for HNRNPCL1 Gene

Relevant External Links for HNRNPCL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HNRNPCL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPCL1 Gene

Publications for HNRNPCL1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  5. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3 65

Products for HNRNPCL1 Gene

Sources for HNRNPCL1 Gene

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