Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HNRNPC Gene

Aliases for HNRNPC Gene

  • Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) 2 3 5
  • HnRNP C1/C2 3 4
  • HNRPC 3 4
  • Heterogeneous Nuclear Ribonucleoproteins C1/C2 3
  • Nuclear Ribonucleoprotein Particle C1 Protein 3
  • Nuclear Ribonucleoprotein Particle C2 Protein 3
  • HNRNP 3
  • SNRPC 3
  • C1 3
  • C2 3

External Ids for HNRNPC Gene

Previous HGNC Symbols for HNRNPC Gene

  • HNRPC

Previous GeneCards Identifiers for HNRNPC Gene

  • GC14M020747
  • GC14M021677
  • GC14M001797

Summaries for HNRNPC Gene

Entrez Gene Summary for HNRNPC Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPC Gene

HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2)) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is HNRNPCL1.

UniProtKB/Swiss-Prot for HNRNPC Gene

  • Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3-UTR or 5-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named m(6)A-switch, facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

Gene Wiki entry for HNRNPC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPC Gene

Genomics for HNRNPC Gene

Regulatory Elements for HNRNPC Gene

Enhancers for HNRNPC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G021307 1.3 Ensembl ENCODE 11.8 -39.1 -39107 2.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 RPGRIP1 HNRNPC SNORD9 SNORD8 UBA52P2 MRPS17P6 ENSG00000260830
GH14G021241 0.9 ENCODE dbSUPER 12 +28.1 28088 0.2 CTCF MAFG RAD21 ZNF316 MAFF POLR2A MAFK SUPT5H RBFOX2 SNORD9 UBA52P2 SNORD8 HNRNPC SUPT16H GC14P021259 GC14P021211 GC14P021210
GH14G021297 0.8 ENCODE 11.4 -28.7 -28710 1.7 PKNOX1 THRB ZNF48 RARA POLR3A ZNF366 HMG20B CEBPB KLF16 PBX2 PARP2 RPGRIP1 TMEM55B HNRNPC SNORD9 SNORD8 UBA52P2 ENSG00000258515 SALL2 MRPS17P6
GH14G021203 0.7 ENCODE 10.9 +65.4 65401 1.7 SOX13 ARID4B GATA4 POLR2A PAF1 ZNF639 GATAD2A SOX5 HMG20B SMAD5 SNORD9 SNORD8 UBA52P2 HNRNPC OR5AU1 LINC00641 LOC100129923
GH14G021343 0.4 Ensembl 11.2 -73.6 -73607 0.2 ZNF652 RPGRIP1 HNRNPC SNORD9 SNORD8 UBA52P2 SALL2 ENSG00000260830 MRPS17P6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HNRNPC on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066468 1194 3401 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for HNRNPC Gene

Chromosome:
14
Start:
21,209,136 bp from pter
End:
21,269,494 bp from pter
Size:
60,359 bases
Orientation:
Minus strand

Genomic View for HNRNPC Gene

Genes around HNRNPC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPC Gene

Proteins for HNRNPC Gene

  • Protein details for HNRNPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07910-HNRPC_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoproteins C1/C2
    Protein Accession:
    P07910
    Secondary Accessions:
    • D3DS19
    • D3DS22
    • P22628
    • Q53EX2
    • Q59FD3
    • Q5FWE8
    • Q86SF8
    • Q86U45
    • Q96HK7
    • Q96HM4
    • Q96IY5
    • Q9BTS3

    Protein attributes for HNRNPC Gene

    Size:
    306 amino acids
    Molecular mass:
    33670 Da
    Quaternary structure:
    • Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1.
    SequenceCaution:
    • Sequence=BAD92764.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPC Gene

    Alternative splice isoforms for HNRNPC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPC Gene

Post-translational modifications for HNRNPC Gene

  • Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.
  • Sumoylated. Sumoylation reduces affinity for mRNA.
  • Ubiquitination at posLast=88 and posLast=8989
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HNRNPC (hnRNP C1/C2)

No data available for DME Specific Peptides for HNRNPC Gene

Domains & Families for HNRNPC Gene

Gene Families for HNRNPC Gene

Protein Domains for HNRNPC Gene

Graphical View of Domain Structure for InterPro Entry

P07910

UniProtKB/Swiss-Prot:

HNRPC_HUMAN :
  • Belongs to the RRM HNRPC family. RALY subfamily.
Family:
  • Belongs to the RRM HNRPC family. RALY subfamily.
genes like me logo Genes that share domains with HNRNPC: view

Function for HNRNPC Gene

Molecular function for HNRNPC Gene

UniProtKB/Swiss-Prot Function:
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3-UTR or 5-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named m(6)A-switch, facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

Gene Ontology (GO) - Molecular Function for HNRNPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16217013
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16217013
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding NAS 9731529
GO:0003730 mRNA 3-UTR binding IDA 16010978
genes like me logo Genes that share ontologies with HNRNPC: view
genes like me logo Genes that share phenotypes with HNRNPC: view

Animal Model Products

miRNA for HNRNPC Gene

miRTarBase miRNAs that target HNRNPC

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPC Gene

Localization for HNRNPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPC Gene

Nucleus. Note=Component of ribonucleosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPC gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for HNRNPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 16217013
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm TAS,IDA --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005697 colocalizes_with telomerase holoenzyme complex IDA 18082603
genes like me logo Genes that share ontologies with HNRNPC: view

Pathways & Interactions for HNRNPC Gene

genes like me logo Genes that share pathways with HNRNPC: view

Pathways by source for HNRNPC Gene

1 KEGG pathway for HNRNPC Gene
1 Qiagen pathway for HNRNPC Gene

SIGNOR curated interactions for HNRNPC Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HNRNPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing TAS 3110598
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with HNRNPC: view

Drugs & Compounds for HNRNPC Gene

(2) Drugs for HNRNPC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for HNRNPC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HNRNPC: view

Transcripts for HNRNPC Gene

Unigene Clusters for HNRNPC Gene

Heterogeneous nuclear ribonucleoprotein C (C1/C2):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b · 11c ^ 12a ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - -
SP10: - -
SP11: -
SP12: - - -
SP13: - -
SP14:
SP15: - - - - - - - - - - - -
SP16:

ExUns: 12b · 12c · 12d · 12e ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for HNRNPC Gene

GeneLoc Exon Structure for
HNRNPC
ECgene alternative splicing isoforms for
HNRNPC

Expression for HNRNPC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPC Gene

Protein differential expression in normal tissues from HIPED for HNRNPC Gene

This gene is overexpressed in Tlymphocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HNRNPC Gene



Protein tissue co-expression partners for HNRNPC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPC Gene:

HNRNPC

SOURCE GeneReport for Unigene cluster for HNRNPC Gene:

Hs.508848

Evidence on tissue expression from TISSUES for HNRNPC Gene

  • Nervous system(5)
  • Blood(4.8)
  • Eye(4.8)
  • Liver(4.8)
  • Bone marrow(4.4)
  • Lung(4.4)
  • Skin(4.2)
  • Intestine(3.8)
  • Kidney(3.6)
  • Pancreas(3.6)
  • Stomach(3.1)
  • Heart(2.5)
  • Bone(2.3)
  • Lymph node(2.2)
  • Adrenal gland(2.1)
  • Muscle(2.1)
  • Spleen(2.1)
  • Thyroid gland(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with HNRNPC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPC Gene

Orthologs for HNRNPC Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPC 34 35
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia HNRPC 35
  • 98 (a)
OneToMany
LOC510852 34
  • 96.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 98 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC475399 34
  • 96.28 (n)
-- 35
  • 95 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hnrnpc 34 16
  • 93.55 (n)
Ralyl 35
  • 71 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Hnrnpc 34
  • 93.33 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6109 34
African clawed frog
(Xenopus laevis)
Amphibia LOC397793 34
zebrafish
(Danio rerio)
Actinopterygii zgc:55733 35
  • 65 (a)
ManyToMany
hnrnpc 35
  • 59 (a)
ManyToMany
zgc55733 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3917 34
fruit fly
(Drosophila melanogaster)
Insecta CG42458 35
  • 12 (a)
OneToMany
Species where no ortholog for HNRNPC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPC Gene

ENSEMBL:
Gene Tree for HNRNPC (if available)
TreeFam:
Gene Tree for HNRNPC (if available)

Paralogs for HNRNPC Gene

Variants for HNRNPC Gene

Sequence variations from dbSNP and Humsavar for HNRNPC Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000034143 -- 21,253,416(+) TTGCA(C/G)TGAGA intron-variant
rs1000066094 -- 21,258,209(+) AACAT(A/G)GTGAA intron-variant
rs1000067378 -- 21,259,758(+) ATCTC(C/T)TACTT intron-variant
rs1000077475 -- 21,257,969(+) ACATA(C/T)ACACA intron-variant
rs1000102943 -- 21,208,836(+) AACCC(C/T)ACCAT downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HNRNPC Gene

Variant ID Type Subtype PubMed ID
esv1560508 CNV insertion 17803354
esv2656744 CNV deletion 23128226
esv2748453 CNV deletion 23290073
esv3335931 CNV insertion 20981092
esv3633707 CNV loss 21293372
nsv1113621 CNV deletion 24896259
nsv509527 CNV insertion 20534489
nsv974313 CNV duplication 23825009
nsv983803 CNV duplication 23825009

Variation tolerance for HNRNPC Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPC Gene

Disorders for HNRNPC Gene

Relevant External Links for HNRNPC

Genetic Association Database (GAD)
HNRNPC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPC

No disorders were found for HNRNPC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPC Gene

Publications for HNRNPC Gene

  1. Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells. (PMID: 16010978) Shetty S. (Mol. Cell. Biochem. 2005) 3 4 22 64
  2. Heterogeneous nuclear ribonucleoprotein C modulates translation of c- myc mRNA in a cell cycle phase-dependent manner. (PMID: 12509468) Kim J.H. … Jang S.K. (Mol. Cell. Biol. 2003) 3 4 22 64
  3. Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2. (PMID: 12564933) Stone J.R. … Collins T. (Biochemistry 2003) 3 4 22 64
  4. 1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins. (PMID: 1385725) Witteking M. … Mueller L. (Biochemistry 1992) 3 4 22 64
  5. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. (PMID: 25719671) Liu N. … Pan T. (Nature 2015) 3 4 64

Products for HNRNPC Gene

Sources for HNRNPC Gene

Content
Loading form....