Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HNRNPC Gene

Aliases for HNRNPC Gene

  • Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) 2 3 5
  • HnRNP C1/C2 3 4
  • HNRPC 3 4
  • Nuclear Ribonucleoprotein Particle C1 Protein 3
  • Nuclear Ribonucleoprotein Particle C2 Protein 3
  • HNRNP 3
  • SNRPC 3
  • C1 3
  • C2 3

External Ids for HNRNPC Gene

Previous HGNC Symbols for HNRNPC Gene

  • HNRPC

Previous GeneCards Identifiers for HNRNPC Gene

  • GC14M020747
  • GC14M021677
  • GC14M001797

Summaries for HNRNPC Gene

Entrez Gene Summary for HNRNPC Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPC Gene

HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2)) is a Protein Coding gene. Diseases associated with HNRNPC include systemic lupus erythematosus and connective tissue disease. Among its related pathways are Gene Expression and Complement and coagulation cascades. GO annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is HNRNPCL3.

UniProtKB/Swiss-Prot for HNRNPC Gene

  • Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named m(6)A-switch to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3-UTR or 5-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).

Gene Wiki entry for HNRNPC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPC Gene

Genomics for HNRNPC Gene

Regulatory Elements for HNRNPC Gene

Promoters for HNRNPC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HNRNPC on UCSC Golden Path with GeneCards custom track

Genomic Location for HNRNPC Gene

Chromosome:
14
Start:
21,209,136 bp from pter
End:
21,269,494 bp from pter
Size:
60,359 bases
Orientation:
Minus strand

Genomic View for HNRNPC Gene

Genes around HNRNPC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPC Gene

Proteins for HNRNPC Gene

  • Protein details for HNRNPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07910-HNRPC_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoproteins C1/C2
    Protein Accession:
    P07910
    Secondary Accessions:
    • D3DS19
    • D3DS22
    • P22628
    • Q53EX2
    • Q59FD3
    • Q5FWE8
    • Q86SF8
    • Q86U45
    • Q96HK7
    • Q96HM4
    • Q96IY5
    • Q9BTS3

    Protein attributes for HNRNPC Gene

    Size:
    306 amino acids
    Molecular mass:
    33670 Da
    Quaternary structure:
    • Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1.
    SequenceCaution:
    • Sequence=BAD92764.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPC Gene

    Alternative splice isoforms for HNRNPC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPC Gene

Proteomics data for HNRNPC Gene at MOPED

Post-translational modifications for HNRNPC Gene

  • Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.
  • Sumoylated. Sumoylation reduces affinity for mRNA.
  • Ubiquitination at Lys 8 and Lys 89
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HNRNPC (hnRNP C1/C2)

No data available for DME Specific Peptides for HNRNPC Gene

Domains & Families for HNRNPC Gene

Gene Families for HNRNPC Gene

Protein Domains for HNRNPC Gene

Graphical View of Domain Structure for InterPro Entry

P07910

UniProtKB/Swiss-Prot:

HNRPC_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRM HNRPC family. RALY subfamily.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RRM HNRPC family. RALY subfamily.
genes like me logo Genes that share domains with HNRNPC: view

Function for HNRNPC Gene

Molecular function for HNRNPC Gene

UniProtKB/Swiss-Prot Function:
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named m(6)A-switch to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3-UTR or 5-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).

Gene Ontology (GO) - Molecular Function for HNRNPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16217013
GO:0003676 nucleic acid binding IEA --
GO:0003729 mRNA binding IEA --
GO:0031492 nucleosomal DNA binding IDA 16217013
genes like me logo Genes that share ontologies with HNRNPC: view
genes like me logo Genes that share phenotypes with HNRNPC: view

Animal Model Products

miRNA for HNRNPC Gene

miRTarBase miRNAs that target HNRNPC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPC Gene

Localization for HNRNPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPC Gene

Nucleus. Note=Component of ribonucleosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPC Gene COMPARTMENTS Subcellular localization image for HNRNPC gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for HNRNPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 16217013
GO:0005697 colocalizes_with telomerase holoenzyme complex IDA 18082603
GO:0005829 cytosol IDA 16010978
GO:0043234 protein complex IDA 16217013
GO:0045120 pronucleus IEA --
genes like me logo Genes that share ontologies with HNRNPC: view

Pathways & Interactions for HNRNPC Gene

genes like me logo Genes that share pathways with HNRNPC: view

SIGNOR curated interactions for HNRNPC Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HNRNPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016925 protein sumoylation TAS --
genes like me logo Genes that share ontologies with HNRNPC: view

Drugs & Compounds for HNRNPC Gene

(2) Drugs for HNRNPC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for HNRNPC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HNRNPC: view

Transcripts for HNRNPC Gene

Unigene Clusters for HNRNPC Gene

Heterogeneous nuclear ribonucleoprotein C (C1/C2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b · 11c ^ 12a ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - -
SP10: - -
SP11: -
SP12: - - -
SP13: - -
SP14:
SP15: - - - - - - - - - - - -
SP16:

ExUns: 12b · 12c · 12d · 12e ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for HNRNPC Gene

GeneLoc Exon Structure for
HNRNPC
ECgene alternative splicing isoforms for
HNRNPC

Expression for HNRNPC Gene

mRNA expression in normal human tissues for HNRNPC Gene

Protein differential expression in normal tissues from HIPED for HNRNPC Gene

This gene is overexpressed in Tlymphocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HNRNPC Gene



SOURCE GeneReport for Unigene cluster for HNRNPC Gene Hs.508848

genes like me logo Genes that share expression patterns with HNRNPC: view

Protein tissue co-expression partners for HNRNPC Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPC Gene

Orthologs for HNRNPC Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPC 36
  • 100 (a)
OneToOne
HNRNPC 35
  • 99.66 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia LOC510852 35
  • 96.47 (n)
  • 98.63 (a)
HNRPC 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 95 (a)
ManyToMany
LOC475399 35
  • 96.28 (n)
  • 98.36 (a)
mouse
(Mus musculus)
Mammalia Ralyl 36
  • 71 (a)
ManyToMany
Hnrnpc 16
Hnrnpc 35
  • 93.55 (n)
  • 98.03 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hnrnpc 35
  • 93.33 (n)
  • 98.03 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC397793 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6109 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3917 35
zebrafish
(Danio rerio)
Actinopterygii zgc55733 35
hnrnpc 36
  • 59 (a)
ManyToMany
zgc:55733 36
  • 65 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42458 36
  • 12 (a)
OneToMany
Species with no ortholog for HNRNPC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPC Gene

ENSEMBL:
Gene Tree for HNRNPC (if available)
TreeFam:
Gene Tree for HNRNPC (if available)

Paralogs for HNRNPC Gene

Paralogs for HNRNPC Gene

genes like me logo Genes that share paralogs with HNRNPC: view

Variants for HNRNPC Gene

Sequence variations from dbSNP and Humsavar for HNRNPC Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7495 -- 21,209,535(+) TTGAC(C/T)GAATT downstream-variant-500B, utr-variant-3-prime
rs1064879 -- 21,210,938(-) GTTTT(A/T)ATCAA utr-variant-3-prime
rs1064971 -- 21,211,128(-) AGTAT(C/T)TTCAG utr-variant-3-prime
rs1142288 -- 21,263,848(-) AATCT(C/G)TTCTC intron-variant, upstream-variant-2KB
rs1957415 -- 21,215,825(+) ATCTG(C/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPC Gene

Variant ID Type Subtype PubMed ID
dgv1852n71 CNV Gain 21882294
esv2656744 CNV Deletion 23128226
esv2748453 CNV Deletion 23290073
nsv509527 CNV Insertion 20534489
esv1560508 CNV Insertion 17803354

Variation tolerance for HNRNPC Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPC Gene

HapMap Linkage Disequilibrium report
HNRNPC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPC Gene

Disorders for HNRNPC Gene

MalaCards: The human disease database

(3) MalaCards diseases for HNRNPC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • lupus nephritis
connective tissue disease
  • connective tissue disorder
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HNRNPC

Genetic Association Database (GAD)
HNRNPC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPC
genes like me logo Genes that share disorders with HNRNPC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPC Gene

Publications for HNRNPC Gene

  1. Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells. (PMID: 16010978) Shetty S. (Mol. Cell. Biochem. 2005) 3 4 23 67
  2. Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. (PMID: 20020773) Freibaum B.D. … Taylor J.P. (J. Proteome Res. 2010) 3 23
  3. Up-regulation of a hydrogen peroxide-responsive pre-mRNA binding protein in atherosclerosis and intimal hyperplasia. (PMID: 18508286) Panchenko M.P. … Stone J.R. (Cardiovasc. Pathol. 2009) 3 23
  4. Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex. (PMID: 19740742) Mosessian S. … Wu H. (J. Biol. Chem. 2009) 3 23
  5. Posttranscriptional regulation of urokinase receptor expression by heterogeneous nuclear ribonuclear protein C. (PMID: 18494499) Velusamy T. … Shetty S. (Biochemistry 2008) 3 23

Products for HNRNPC Gene

Sources for HNRNPC Gene

Back to Top

Content