Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNRNPC Gene

protein-coding   GIFtS: 59
GCID: GC14M021677

heterogeneous nuclear ribonucleoprotein C (C1/C2)


(Previous symbol: HNRPC)
 Explore 25 diseases affiliated with
HNRNPC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HNRNPC    

Aliases
for HNRNPC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heterogeneous Nuclear Ribonucleoprotein C (C1/C2)1 2     HNRNP2
HNRPC1 2 3     SNRPC2
HnRNP C1/C22 3     Heterogeneous Nuclear Ribonucleoproteins C1/C22
HnRNPC1     Nuclear Ribonucleoprotein Particle C1 Protein2
C12     Nuclear Ribonucleoprotein Particle C2 Protein2
C22     

External Ids:    HGNC: 50351   Entrez Gene: 31832   Ensembl: ENSG000000921997   OMIM: 1640205   UniProtKB: P079103   

Export aliases for HNRNPC gene to outside databases

Previous GC identifers: GC14M020747 GC14M001797


Summaries
for HNRNPC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HNRNPC:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated
with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and
transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the
cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act
as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least
two different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HNRPC_HUMAN, P07910
Function: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240
nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome
assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the
stability and the level of translation of bound mRNA molecules

Gene Wiki entry for HNRNPC


Genomic Views
for HNRNPC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNRNPC gene promoter:
         Bach1   E2F-4   E2F-3a   E2F-5   E2F-2   Cdc5   AREB6   E2F-1   E2F   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HNRNPC promoter sequence
   Search SABiosciences Chromatin IP Primers for HNRNPC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11

HNRNPC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPC gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021677:  view genomic region     (about GC identifiers)

Start:
 21,677,295 bp from pter      End:
 21,737,653 bp from pter
Size:
 60,359 bases      Orientation:
 minus strand

Proteins
for HNRNPC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HNRPC_HUMAN, P07910 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoproteins C1/C2  
Size: 306 amino acids; 33670 Da
Subunit: Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound
pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle.
Identified in the spliceosome C complex. Interacts with IGF2BP1
Subcellular location: Nucleus. Note=Component of ribonucleosomes
Sequence caution: Sequence=BAD92764.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for HNRNPC:
1TXP (3D)        1WF2 (3D)        3LN4 (3D)    
Secondary accessions: D3DS19 D3DS22 P22628 Q53EX2 Q59FD3 Q5FWE8 Q86SF8 Q86U45 Q96HK7 Q96HM4 Q96IY5
Q9BTS3
Alternative splicing: 4 isoforms:  P07910-1   P07910-2   P07910-3   P07910-4   (Contains a phosphoserine at position 107. Contains a phosphoserine at position 108)

Explore the universe of human proteins at neXtProt for HNRNPC: NX_P07910

Post-translational modifications:

  • Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the
    • poly-Ser stretch at position 238 in response to hydrogen peroxide1
  • Sumoylated. Sumoylation reduces affinity for mRNA1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P07910

    • HNRNPC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001070910.1  NP_001070911.1  NP_004491.2  NP_112604.2  

    ENSEMBL proteins: 
     ENSP00000338095   ENSP00000450725   ENSP00000451187   ENSP00000451291   ENSP00000442816  
     ENSP00000450548   ENSP00000451708   ENSP00000450790   ENSP00000452599   ENSP00000451652  
     ENSP00000450629   ENSP00000452214   ENSP00000452276   ENSP00000450544   ENSP00000451176  
     ENSP00000404848   ENSP00000450601   ENSP00000452545   ENSP00000452021   ENSP00000452213  
     ENSP00000452185   ENSP00000450467   ENSP00000451292   ENSP00000452573   ENSP00000451892  
     ENSP00000450669   ENSP00000319690   ENSP00000404559  
    Reactome Protein details: P07910
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HNRNPC
    OriGene Protein Over-expression Lysate (see all 5): HNRNPC
    OriGene Custom Protein Services for HNRNPC 
    GenScript Custom Purified and Recombinant Proteins Services for HNRNPC
    Novus Biologicals HNRNPC Proteins
    Novus Biologicals HNRNPC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HNRNPC

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0030529ribonucleoprotein complex ----
    GO:0045120pronucleus ----
    GO:0071013catalytic step 2 spliceosome IDA11991638


    HNRNPC for ontologies           About GeneDecksing



    HNRNPC Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HNRNPC
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): HNRNPC
    OriGene Custom Antibody Services for HNRNPC 
    GenScript Superior Antibodies for HNRNPC
    Novus Biologicals HNRNPC Antibodies
    Abcam antibodies for HNRNPC 
    Uscn Antibodies for HNRNPC
    ThermoFisher Antibody for HNRNPC

    Assay Products for HNRNPC: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HNRNPC
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HNRNPC

    Protein Domains /
    Families
    for HNRNPC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HNRNPC for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017347 hnRNP_C_Raly
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P07910

    ProtoNet protein and cluster: P07910

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: HNRPC_HUMAN, P07910
    Similarity: Belongs to the RRM HNRPC family. RALY subfamily
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Function
    for HNRNPC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HNRPC_HUMAN, P07910
    Function: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240
    nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome
    assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the
    stability and the level of translation of bound mRNA molecules

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 4): HNRNPC
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HNRNPC
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRNPC (see all 78):
    hsa-miR-3607-3p hsa-miR-30d hsa-miR-3916 hsa-miR-3162-5p hsa-miR-1273d hsa-miR-3161 hsa-miR-30a hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: HNRNPC 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HNRNPC (see all 4)
    OriGene shRNA RFP: HNRNPC
    OriGene siRNA: HNRNPC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HNRNPC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HNRNPC

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPC (see all 10)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPC (see all 7)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): HNRNPC (NM_001077442)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPC 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HNRNPC
    Search LifeMap BioReagents cell lines for HNRNPC

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPC

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding NAS9731529
    GO:0003729mRNA binding ----
    GO:0005515protein binding IPI17289661


    HNRNPC for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for HNRNPC:
     Decreased homologous recombina  Decreased viability  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hnrnpc):
     embryogenesis  mortality/aging 

    HNRNPC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HNRNPC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA Splicing1.00
    		mRNA Processing0.82
    		mRNA Splicing - Major Pathway1.00
    		mRNA processing0.48
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    		Spliceosome0.31
    2Regulation of Telomerase
    		Regulation of Telomerase1.00
    3Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for HNRNPC 
        mRNA processing
    Regulation of Telomerase

    5        Reactome Pathways for HNRNPC
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA


    1         Kegg Pathway  (Kegg details for HNRNPC):
        Spliceosome


    HNRNPC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HNRNPC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1055 Interacting proteins for HNRNPC (P079101, 2, 3 ENSP000003196904) via UniProtKB, MINT, STRING, and/or I2D (see all 1055)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHX9Q082112, 3, ENSP000003565204MINT-7945693 MINT-6489539 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000356520
    EIF4A3P389192, 3, ENSP000002693494MINT-7945693 MINT-7947479 MINT-6488791 I2D: score=2 STRING: ENSP00000269349
    SMARCC1Q929222, 3, ENSP000002544804MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000254480
    YWHAZP631042, 3, ENSP000003095034MINT-3296904 MINT-7899812 I2D: score=1 STRING: ENSP00000309503
    HNRNPCP079101, 2EBI-357966,EBI-357966 MINT-6489539 MINT-67051 MINT-8335836
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--


    HNRNPC for ontologies           About GeneDecksing



    Drugs & Compounds
    for HNRNPC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HNRNPC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HNRNPC
    6 Novoseek chemical compound relationships for HNRNPC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly c 53.4 2 1729596 (1)
    poly u 49.5 1 9516488 (1)
    adenylate 26.8 1 12945950 (1)
    arginine 20.9 1 9891755 (1)
    h2o2 8.99 5 12564933 (2), 15687492 (1), 11877401 (1), 17626781 (1)
    tyrosine 0 3 18494499 (3)

    Search CenterWatch for drugs/clinical trials and news about HNRNPC / HNRPC 

    Transcripts
    for HNRNPC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HNRNPC gene (4 alternative transcripts): 
    NM_001077442.1  NM_001077443.1  NM_004500.3  NM_031314.2  

    Unigene Clusters for HNRNPC:

    Heterogeneous nuclear ribonucleoprotein C (C1/C2)
    Hs.508848  [show with all ESTs], Hs.700762  [show with all ESTs]
    Unigene Representative Sequences: AK126950, BQ229088
    18/34 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):
    ENST00000336053(uc001wae.3) ENST00000554969 ENST00000556142 ENST00000554455
    ENST00000430246 ENST00000553753(uc010tlr.2) ENST00000555914 ENST00000555309
    ENST00000557442 ENST00000556628 ENST00000555883 ENST00000556513 ENST00000553444
    ENST00000557201 ENST00000553300 ENST00000556897 ENST00000420743 ENST00000557157


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): HNRNPC
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HNRNPC
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRNPC (see all 78):
    hsa-miR-3607-3p hsa-miR-30d hsa-miR-3916 hsa-miR-3162-5p hsa-miR-1273d hsa-miR-3161 hsa-miR-30a hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: HNRNPC 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HNRNPC (see all 4)
    OriGene shRNA RFP: HNRNPC
    OriGene siRNA: HNRNPC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HNRNPC
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPC (see all 10)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPC (see all 7)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): HNRNPC (NM_001077442)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPC 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HNRNPC
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HNRNPC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HNRNPC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRNPC

    Additional cDNA sequence: Z70766.1 

    24/124 DOTS entries (see all 124):

    DT.100865690  DT.91957243  DT.91781270  DT.95184722  DT.100721679  DT.100721719  DT.100721714  DT.75185372 
    DT.95154289  DT.87018408  DT.100721736  DT.95154238  DT.100721734  DT.100721703  DT.100721713  DT.120756840 
    DT.40275536  DT.100800446  DT.95154210  DT.120756704  DT.120756778  DT.101986706  DT.92363090  DT.91781287 

    24/1446 AceView cDNA sequences (see all 1446):

    BQ438191 AI831097 BE733136 BX443099 CR620247 F02550 CA393706 AI081230 
    AI859285 CN483823 BQ017800 AA319229 BM458248 BU625215 AA362010 BM913849 
    BE257683 BF794719 BM794997 CB136740 BU162224 BI258585 BM454510 BG570019 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPC (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b · 11c ^ 12a ·
    SP1:                    -     -     -     -     -     -                             -                                                                           
    SP2:                          -           -     -     -                       -     -                                                                           
    SP3:                    -                 -     -     -                             -                                                                           
    SP4:                          -           -     -     -                             -                                                                           
    SP5:                    -                 -     -     -                       -     -                                                                           

    ExUns: 12b · 12c · 12d · 12e ^ 13a · 13b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for HNRNPC

    Expression
    for HNRNPC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNRNPC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAAGGACAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HNRNPC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HNRNPC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNRNPC

    SOURCE GeneReport for Unigene clusters: Hs.508848 Hs.700762
        SABiosciences Custom PCR Arrays for HNRNPC
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HNRNPC
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HNRNPC
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HNRNPC
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRNPC
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPC

    Orthologs
    for HNRNPC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HNRNPC gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 93(a)
    79(a)
    		 many ↔ many
    many ↔ many
    		 GL343466.1(326034-328872)
    GL343466.1(320837-324493)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3977932 C protein 74.95(n)    J03831.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc557332 similar to heterogeneous nuclear ribonucleoprotein more 74.64(n)   393968  BC046891.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG424586
    		 --
    		 10(a)
    		 1 → many
    		 3L(7416927-7447719)


    ENSEMBL Gene Tree for HNRNPC (if available)
    TreeFam Gene Tree for HNRNPC (if available) 

    Paralogs
    for HNRNPC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HNRNPC gene
    RALY2  RALYL2  HNRNPCL12  
    10 SIMAP similar genes for HNRNPC using alignment to 16 protein entries:     HNRPC_HUMAN (see all proteins):
    HNRPC    HNRPCL1    HNRNPCL1    LOC649330    LOC440563    RALYL
    RALY    SFRS5    SRSF5    RBMX

    HNRNPC for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for HNRNPC (see all 11)
    PGOHUM00000261834 PGOHUM00000261836 PGOHUM00000261837 PGOHUM00000261852 PGOHUM00000261871


    Genomic Variants
    for HNRNPC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1162 NCBI SNPs in HNRNPC are shown (see all 1162)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs171135161,2
    		C,F,H,--1798637(+) AAAGGG/CTGCCA 4 -- ut31 ese328Minor allele frequency- C:0.15NA EA NS WA CSA 2570
    rs115591221,2
    		C--1799142(+) CCCCAC/TACAGC 4 -- ut31 ese31Minor allele frequency- T:0.00NA 2
    rs32034521,2
    		--1799315(-) TTTATA/CAACTG 4 -- ut310--------
    rs10648791,2
    		--1799318(-) GTTTTA/TATCAA 4 -- ut310--------
    rs763863611,2
    		--1800548(+) ACAGTG/AACTAT 4 -- int11Minor allele frequency- A:0.01NA 120
    rs171025951,2
    		C,F,H,--1801919(+) CAATTA/TAAAGG 4 -- int119Minor allele frequency- T:0.13NA NS EA WA 1350
    rs49824261,2
    		C,F,A,H,--1802459(+) TCATTT/GCCATA 4 -- int118Minor allele frequency- G:0.14NA NS EA WA CSA 929
    rs714102671,2
    		C,F--1802607(+) ACAAAC/TGTGAT 4 -- int12Minor allele frequency- T:0.50NA 4
    rs1117000461,2
    		C,--1803006(+) TGGTTA/GATCTC 4 -- int12Minor allele frequency- G:0.05CSA WA 120
    rs756604271,2
    		F,--1803564(+) GCTTTT/CAGTTA 4 -- int11Minor allele frequency- C:0.11WA 118

    HapMap Linkage Disequilibrium report for HNRNPC (21677295 - 21737653 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HNRNPC: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HNRNPC
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPC

    Disorders / Diseases
    for HNRNPC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HNRNPC for disorders           About GeneDecksing

    OMIM gene information: 164020    OMIM disorders: --

    20/25 diseases for HNRNPC (see all 25):    About MalaCards
    mixed connective tissue disease    transient global amnesia    connective tissue disease    oculopharyngeal muscular dystrophy
    lupus erythematosus    muscular dystrophy    systemic lupus erythematosus    myotonic dystrophy
    rheumatoid arthritis    muscular atrophy    acute myeloid leukemia    myeloid leukemia
    bipolar disorder    hepatitis c    hepatitis b    arthritis
    hepatocellular carcinoma    hepatitis    leukemia    lung cancer

    1 disease from the University of Copenhagen DISEASES database for HNRNPC:
    Mixed connective tissue disease

    7 Novoseek disease relationships for HNRNPC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mixed connective tissue disease 64.7 2 8957102 (1)
    rheumatic diseases 38.3 2 18240226 (1), 7779120 (1)
    lupus erythematosus systemic 23.2 2 8957102 (1)
    rheumatoid arthritis 11.7 2 8957102 (1)
    cancer lung 0 6 12871776 (5)
    tumors 0 2 17627933 (1), 19013444 (1)
    cancer 0 1 20010808 (1)


    Export disorders for HNRNPC gene to outside databases

    Publications
    for HNRNPC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNRNPC gene, integrated from 9 sources (see all 215):
    (articles sorted by number of sources associating them with HNRNPC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells. (PubMed id 16010978)1, 2, 9 Shetty S. (2005)
    2. Heterogeneous nuclear ribonucleoprotein C modulates translation of c- myc mRNA in a cell cycle phase-dependent manner. (PubMed id 12509468)1, 2, 9 Kim J.H....Jang S.K. (2003)
    3. Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2. (PubMed id 12564933)1, 2, 9 Stone J.R.... Collins T. (2003)
    4. 1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins. (PubMed id 1385725)1, 2, 9 Witteking M.... Mueller L. (1992)
    5. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    6. Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)1, 2 Beranova-Giorgianni S.... Giorgianni F. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Solution structure of the symmetric coiled coil tetramer formed by the oligomerization domain of hnRNP C: implications for biological function. (PubMed id 15936032)1, 2 Whitson S.R.... Krezel A.M. (2005)
    9. SUMO modification of heterogeneous nuclear ribonucleoproteins. (PubMed id 15082759)1, 2 Vassileva M.T. and Matunis M.J. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for HNRNPC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HNRNPC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3183 HGNC: 5035 AceView: HNRPC Ensembl:ENSG00000092199 euGenes: HUgn3183
    ECgene: HNRNPC Kegg: 3183 H-InvDB: HNRNPC

    Other Databases showing HNRNPC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HNRNPC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNRNPC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HNRNPC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HNRNPC gene:
    Search GeneIP for patents involving HNRNPC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HNRNPC gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HNRNPC
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for HNRNPC   OriGene shRNA RFP for HNRNPC  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HNRNPC   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HNRNPC  
     OriGene Protein Over-expression Lysate for HNRNPC   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HNRNPC   OriGene 3'-UTR Clone for HNRNPC  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPC   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPC  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for HNRNPC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HNRNPC   OriGene Custom Protein Services for HNRNPC  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HNRNPC
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HNRNPC
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPC
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HNRNPC
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRNPC
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HNRNPC
     GenScript Custom Purified and Recombinant Proteins Services for HNRNPC GenScript cDNA clones with any tag delivered in your preferred vector for HNRNPC
     GenScript Custom Assay Services for HNRNPC GenScript Superior Antibodies for HNRNPC
     GenScript Custom overexpressing Cell Line Services for HNRNPC CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HNRNPC promoter
     Search Chromatin IP Primers for HNRNPC
     RT2 qPCR Primer Assay in human, mouse, rat HNRNPC
     GNC Network for HNRNPC
     SABiosciences Custom PCR Arrays for HNRNPC
     Search Tocris compounds for HNRNPC
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HNRNPC antibodies
     HNRNPC proteins
     HNRNPC lysates
     Antibodies for HNRNPC
     See all of Abcam's Antibodies, Kits and Proteins for HNRNPC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HNRNPC Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HNRNPC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPC
     SwitchGear 3'UTR luciferase reporter plasmids for HNRNPC
     SwitchGear Promoter luciferase reporter plasmids for HNRNPC
     ThermoFisher Antibody for HNRNPC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPC
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HNRNPC gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4