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HNRNPC Gene

protein-coding   GIFtS: 62
GCID: GC14M021677

Heterogeneous Nuclear Ribonucleoprotein C (C1/C2)


(Previous symbol: HNRPC)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein C (C1/C2)1 2     HNRNP2
HNRPC1 2 3 5     SNRPC2
HnRNP C1/C22 3     Heterogeneous Nuclear Ribonucleoproteins C1/C22
C12     Nuclear Ribonucleoprotein Particle C1 Protein2
C22     Nuclear Ribonucleoprotein Particle C2 Protein2

External Ids:    HGNC: 50351   Entrez Gene: 31832   Ensembl: ENSG000000921997   OMIM: 1640205   UniProtKB: P079103   

Export aliases for HNRNPC gene to outside databases

Previous GC identifers: GC14M020747 GC14M001797


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPC Gene:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are
associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA
metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the
nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded
by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript
variants encoding at least two different isoforms have been described for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for HNRNPC Gene:
HNRNPC (heterogeneous nuclear ribonucleoprotein C (C1/C2)) is a protein-coding gene. Diseases associated with HNRNPC include transient global amnesia, and mixed connective tissue disease. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RALY.

UniProtKB/Swiss-Prot: HNRPC_HUMAN, P07910
Function: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240
nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome
assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the
stability and the level of translation of bound mRNA molecules

Gene Wiki entry for HNRNPC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPC gene promoter:
         Bach1   E2F-4   E2F-3a   E2F-5   E2F-2   Cdc5   AREB6   E2F-1   E2F   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRNPC promoter sequence
   Search Chromatin IP Primers for HNRNPC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

HNRNPC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPC gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021677:  view genomic region     (about GC identifiers)

Start:
21,677,295 bp from pter      End:
21,737,653 bp from pter
Size:
60,359 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HNRPC_HUMAN, P07910 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoproteins C1/C2  
Size: 306 amino acids; 33670 Da
Subunit: Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound
pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP
particle. Identified in the spliceosome C complex. Interacts with IGF2BP1
Sequence caution: Sequence=BAD92764.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for HNRNPC:
1TXP (3D)        1WF2 (3D)        3LN4 (3D)    
Secondary accessions: D3DS19 D3DS22 P22628 Q53EX2 Q59FD3 Q5FWE8 Q86SF8 Q86U45 Q96HK7 Q96HM4
Q96IY5 Q9BTS3
Alternative splicing: 4 isoforms:  P07910-1   P07910-2   P07910-3   P07910-4   (Contains a phosphoserine at position 107. Contains a phosphoserine at position 108)

Explore the universe of human proteins at neXtProt for HNRNPC: NX_P07910

Explore proteomics data for HNRNPC at MOPED

Post-translational modifications: 

  • Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the
    poly-Ser stretch at position 238 in response to hydrogen peroxide1
  • Sumoylated. Sumoylation reduces affinity for mRNA1
  • Ubiquitination2 at Lys8, Lys29, Lys39, Lys42, Lys89, Lys206
  • Modification sites at PhosphoSitePlus

  • See HNRNPC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001070910.1  NP_001070911.1  NP_004491.2  NP_112604.2  

    ENSEMBL proteins: 
     ENSP00000338095   ENSP00000450725   ENSP00000451187   ENSP00000451291   ENSP00000442816  
     ENSP00000450548   ENSP00000451708   ENSP00000450790   ENSP00000452599   ENSP00000451652  
     ENSP00000450629   ENSP00000452214   ENSP00000452276   ENSP00000450544   ENSP00000451176  
     ENSP00000404848   ENSP00000450601   ENSP00000452545   ENSP00000452021   ENSP00000452213  
     ENSP00000452185   ENSP00000450467   ENSP00000451292   ENSP00000452573   ENSP00000451892  
     ENSP00000450669   ENSP00000319690   ENSP00000404559  
    Reactome Protein details: P07910

    HNRNPC Human Recombinant Protein Products:

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    HNRNPC Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR017347 hnRNP_C_Raly
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P07910

    ProtoNet protein and cluster: P07910

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: HNRPC_HUMAN, P07910
    Similarity: Belongs to the RRM HNRPC family. RALY subfamily
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    HNRNPC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNRPC_HUMAN, P07910
    Function: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240
    nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome
    assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the
    stability and the level of translation of bound mRNA molecules

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding NAS9731529
    GO:0003729mRNA binding ----
    GO:0005515protein binding IPI15161933
         
    HNRNPC for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for HNRNPC:
     Decreased homologous recombina  Decreased viability  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hnrnpc):
     embryogenesis  mortality/aging 

    HNRNPC for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HNRNPC
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    miRNA
    Products:
        
    miRTarBase miRNAs that target HNRNPC:
    hsa-let-7e-5p (MIRT051596), hsa-mir-455-3p (MIRT037890), hsa-mir-30c-5p (MIRT047904), hsa-mir-186-5p (MIRT045150), hsa-mir-744-5p (MIRT037494), hsa-mir-18a-3p (MIRT040851), hsa-mir-484 (MIRT042196), hsa-mir-505-5p (MIRT037959), hsa-mir-615-3p (MIRT039991), hsa-mir-342-3p (MIRT043694)

    Block miRNA regulation of human, mouse, rat HNRNPC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPC (see all 78):
    hsa-miR-3607-3p hsa-miR-30d hsa-miR-3916 hsa-miR-3162-5p hsa-miR-1273d hsa-miR-3161 hsa-miR-30a hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HNRNPC

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HNRPC_HUMAN, P07910: Nucleus. Note=Component of ribonucleosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005730NOT nucleolus IDA--
    GO:0019013viral nucleocapsid ----

    HNRNPC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPC About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Translational Control
    Translational Control
    4Spliceosome
    Spliceosome
    5Regulation of Telomerase
    Regulation of Telomerase

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HNRNPC
        Classical Complement Pathway
    Lectin Induced Complement Pathway
    Complement Pathway

    1 Cell Signaling Technology (CST) Pathway for HNRNPC
        Translational Control

    2 BioSystems Pathways for HNRNPC
        mRNA processing
    Regulation of Telomerase


    2 Reactome Pathways for HNRNPC
        mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA


    1 Kegg Pathway  (Kegg details for HNRNPC):
        Spliceosome


    HNRNPC for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPC
    Interactions:

        GeneGlobe Interaction Network for HNRNPC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPC (P079101, 2, 3 ENSP000003196904) via UniProtKB, MINT, STRING, and/or I2D (see all 1109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631041, 2, 3, ENSP000003095034EBI-357966,EBI-347088 MINT-3296904 MINT-7899812 I2D: score=1 STRING: ENSP00000309503
    DHX9Q082112, 3, ENSP000003565204MINT-7945693 MINT-6489539 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000356520
    EIF4A3P389192, 3, ENSP000002693494MINT-7945693 MINT-7947479 MINT-6488791 I2D: score=2 STRING: ENSP00000269349
    SMARCC1Q929222, 3, ENSP000002544804MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000254480
    HNRNPCP079101, 2EBI-357966,EBI-357966 MINT-6489539 MINT-67051 MINT-8335836
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--
    GO:0038032termination of G-protein coupled receptor signaling pathway ----

    HNRNPC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPC (HNRPC)

    6 Novoseek inferred chemical compound relationships for HNRNPC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly c 53.4 2 1729596 (1)
    poly u 49.5 1 9516488 (1)
    adenylate 26.8 1 12945950 (1)
    arginine 20.9 1 9891755 (1)
    h2o2 8.99 5 12564933 (2), 15687492 (1), 11877401 (1), 17626781 (1)
    tyrosine 0 3 18494499 (3)



    HNRNPC for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HNRNPC gene (4 alternative transcripts): 
    NM_001077442.1  NM_001077443.1  NM_004500.3  NM_031314.2  

    Unigene Cluster for HNRNPC:

    Heterogeneous nuclear ribonucleoprotein C (C1/C2)
    Hs.508848  [show with all ESTs]
    Unigene Representative Sequence: AK126950
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):
    ENST00000336053(uc001wae.3) ENST00000554969 ENST00000556142 ENST00000554455
    ENST00000430246 ENST00000553753(uc010tlr.2) ENST00000555914 ENST00000555309
    ENST00000557442 ENST00000556628 ENST00000555883 ENST00000556513 ENST00000553444
    ENST00000557201 ENST00000553300 ENST00000556897 ENST00000420743 ENST00000557157


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    Selected qRT-PCR Assays for microRNAs that regulate HNRNPC (see all 78):
    hsa-miR-3607-3p hsa-miR-30d hsa-miR-3916 hsa-miR-3162-5p hsa-miR-1273d hsa-miR-3161 hsa-miR-30a hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPC 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): HNRNPC (NM_001077442)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPC
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPC
      QuantiFast Probe-based Assays in human, mouse, rat HNRNPC

    Additional mRNA sequence: 

    AB209527.1 AK126950.1 AK223517.1 AK225032.1 AK292619.1 AK297482.1 AK298906.1 AK299923.1 
    AK302213.1 AK312338.1 AK312382.1 AL833432.1 BC003394.1 BC007052.1 BC008364.1 BC008423.1 
    BC066932.1 BC071943.1 BC089438.1 BC092433.1 BC103758.1 BC108658.1 BX161480.1 BX247961.1 
    BX247992.1 M16342.1 M29063.1 Z70766.1 

    Selected DOTS entries (see all 124):

    DT.100865690  DT.91957243  DT.91781270  DT.95184722  DT.100721679  DT.100721719  DT.100721714  DT.75185372 
    DT.95154289  DT.87018408  DT.100721736  DT.95154238  DT.100721734  DT.100721703  DT.120756840  DT.100721713 
    DT.40275536  DT.100800446  DT.95154210  DT.120756778  DT.120756704  DT.92363090  DT.101986706  DT.91781287 

    Selected AceView cDNA sequences (see all 1446):

    CD106347 AI819431 BM803927 AA312573 CR594564 BQ049322 CF146605 BU658989 
    CR624349 CA416213 CA392469 BX442913 CB145780 AI311328 CD245438 F03926 
    CR604464 BG387571 CB156829 AW470915 AA356169 BX397733 CB129628 CN482817 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPC (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b · 11c ^ 12a ·
    SP1:                    -     -     -     -     -     -                             -                                                                           
    SP2:                          -           -     -     -                       -     -                                                                           
    SP3:                    -                 -     -     -                             -                                                                           
    SP4:                          -           -     -     -                             -                                                                           
    SP5:                    -                 -     -     -                       -     -                                                                           

    ExUns: 12b · 12c · 12d · 12e ^ 13a · 13b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for HNRNPC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPC expression in normal human tissues (normalized intensities)      HNRNPC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGGACAA
    HNRNPC Expression
    About this image


    HNRNPC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Bone Marrow
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    HNRNPC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508848
        Custom PCR Arrays for HNRNPC
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HNRNPC gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpc1 , 5 heterogeneous nuclear ribonucleoprotein C1, 5 93.55(n)1
    98.03(a)1
      14 (26.79 cM)5
    153811  NM_016884.31  NP_058580.11 
     520733805 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    89(a)
    1 → many
    GL343466.1(320960-329899)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3977932 C protein 74.95(n)    J03831.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc557332 similar to heterogeneous nuclear ribonucleoprotein more 74.64(n)   393968  BC046891.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG424586
    --
    12(a)
    1 → many
    3L(7416927-7447719)


    ENSEMBL Gene Tree for HNRNPC (if available)
    TreeFam Gene Tree for HNRNPC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPC gene
    RALY2  RALYL2  HNRNPCL12  
    10 SIMAP similar genes for HNRNPC using alignment to 16 protein entries:     HNRPC_HUMAN (see all proteins):
    HNRPC    HNRPCL1    HNRNPCL1    LOC649330    LOC440563    RALYL
    RALY    SFRS5    SRSF5    RBMX

    HNRNPC for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for HNRNPC (see all 11)
    PGOHUM00000261834 PGOHUM00000261836 PGOHUM00000261837 PGOHUM00000261852 PGOHUM00000261871


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPC (see all 1433)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118485101,2
    C,F,H--1817364(+) aaaaaG/Aaaaaa 4 -- int1 trp31Minor allele frequency- A:0.50CSA 2
    rs1913667951,2
    --2675255(+) GTCTCC/TTTACT 4 -- ds50010--------
    rs1830790961,2
    --2675355(+) AACACA/GAGGAA 4 -- ds50010--------
    rs1859806921,2
    --2675378(+) GTAGCA/GTAGCC 4 -- ds50010--------
    rs1436876471,2
    C--2675698(+) GCAAAC/GAAAAA 4 -- ds50010--------
    rs1178878751,2
    C,F--2675714(+) AAAAAA/CAGTTA 4 -- ds50011Minor allele frequency- C:0.07NA 120
    rs752617791,2
    --2675729(+) AAATAA/TAAATA 4 -- ds50010--------
    rs1832482821,2
    --2675766(+) ATTTAC/TATTTT 4 -- ut310--------
    rs1481141081,2
    --2676043(+) CACTCC/TCTCCT 4 -- ut310--------
    rs1878626171,2
    --2676044(+) ACTCTC/GTCCTA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for HNRNPC (21677295 - 21737653 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HNRNPC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656744CNV Deletion23128226
    esv2748453CNV Deletion23290073
    nsv509527CNV Insertion20534489
    esv1560508CNV Insertion17803354
    dgv1852n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164020    OMIM disorders: --

    Selected diseases for HNRNPC (see all 37):    About MalaCards
    transient global amnesia    mixed connective tissue disease    oculopharyngeal muscular dystrophy    connective tissue disease
    rheumatic disease    spinal muscular atrophy    myotonic dystrophy    muscular atrophy
    lupus erythematosus    muscular dystrophy    bipolar disorder    rheumatoid arthritis
    arthritis    acute myeloid leukemia    hepatitis c virus    hepatitis
    myeloid leukemia    systemic lupus erythematosus    type 1 diabetes    atherosclerosis

    1 disease from the University of Copenhagen DISEASES database for HNRNPC:
    Mixed connective tissue disease

    HNRNPC for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for HNRNPC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mixed connective tissue disease 64.7 2 8957102 (1)
    rheumatic diseases 38.3 2 18240226 (1), 7779120 (1)
    lupus erythematosus systemic 23.2 2 8957102 (1)
    rheumatoid arthritis 11.7 2 8957102 (1)
    cancer lung 0 6 12871776 (5)
    tumors 0 2 17627933 (1), 19013444 (1)
    cancer 0 1 20010808 (1)

    Genetic Association Database (GAD): HNRNPC

    Export disorders for HNRNPC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPC gene, integrated from 10 sources (see all 240):
    (articles sorted by number of sources associating them with HNRNPC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells. (PubMed id 16010978)1, 2, 9 Shetty S. (Mol. Cell. Biochem. 2005)
    2. Heterogeneous nuclear ribonucleoprotein C modulates translation of c- myc mRNA in a cell cycle phase-dependent manner. (PubMed id 12509468)1, 2, 9 Kim J.H....Jang S.K. (Mol. Cell. Biol. 2003)
    3. Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2. (PubMed id 12564933)1, 2, 9 Stone J.R.... Collins T. (Biochemistry 2003)
    4. 1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins. (PubMed id 1385725)1, 2, 9 Witteking M.... Mueller L. (Biochemistry 1992)
    5. Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. (PubMed id 21738484)1, 4 Smith E.N....Kelsoe J.R. (PLoS Genet. 2011)
    6. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    7. Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)1, 2 Beranova-Giorgianni S.... Giorgianni F. (Pituitary 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Solution structure of the symmetric coiled coil tetramer formed by the oligomerization domain of hnRNP C: implications for biological function. (PubMed id 15936032)1, 2 Whitson S.R.... Krezel A.M. (J. Mol. Biol. 2005)
    10. SUMO modification of heterogeneous nuclear ribonucleoproteins. (PubMed id 15082759)1, 2 Vassileva M.T. and Matunis M.J. (Mol. Cell. Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3183 HGNC: 5035 AceView: HNRPC Ensembl:ENSG00000092199 euGenes: HUgn3183
    ECgene: HNRNPC Kegg: 3183 H-InvDB: HNRNPC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HNRNPC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HNRNPC gene:
    Search GeneIP for patents involving HNRNPC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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