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Aliases for HNRNPAB Gene

Aliases for HNRNPAB Gene

  • Heterogeneous Nuclear Ribonucleoprotein A/B 2 3
  • APOBEC1-Binding Protein 1 3 4
  • HnRNP A/B 3 4
  • HNRPAB 3 4
  • ABBP-1 3 4
  • ABBP1 3 4
  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 1-Binding Protein 1 3
  • Apobec-1 Binding Protein 1 3
  • HnRNP Type A/B Protein 3

External Ids for HNRNPAB Gene

Previous HGNC Symbols for HNRNPAB Gene


Previous GeneCards Identifiers for HNRNPAB Gene

  • GC05P177565
  • GC05P177631
  • GC05P172357

Summaries for HNRNPAB Gene

Entrez Gene Summary for HNRNPAB Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPAB Gene

HNRNPAB (Heterogeneous Nuclear Ribonucleoprotein A/B) is a Protein Coding gene. Diseases associated with HNRNPAB include hay-wells syndrome and wells syndrome. Among its related pathways are mRNA Splicing - Major Pathway and Telomere Extension by Telomerase. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HNRNPA0.

UniProtKB/Swiss-Prot for HNRNPAB Gene

  • Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site

Gene Wiki entry for HNRNPAB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPAB Gene

Genomics for HNRNPAB Gene

Regulatory Elements for HNRNPAB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HNRNPAB Gene

178,204,507 bp from pter
178,211,183 bp from pter
6,677 bases
Plus strand

Genomic View for HNRNPAB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPAB Gene

Proteins for HNRNPAB Gene

  • Protein details for HNRNPAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A/B
    Protein Accession:
    Secondary Accessions:
    • B3KNN5
    • D3DWP7
    • Q04150
    • Q8N7U3
    • Q9BQ99

    Protein attributes for HNRNPAB Gene

    332 amino acids
    Molecular mass:
    36225 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APOBEC1.
    • Sequence=AAC50956.1; Type=Frameshift; Positions=296, 307, 330; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPAB Gene

    Alternative splice isoforms for HNRNPAB Gene


neXtProt entry for HNRNPAB Gene

Proteomics data for HNRNPAB Gene at MOPED

Post-translational modifications for HNRNPAB Gene

  • Dimethylation at Arg-322 is probably asymmetric
  • Ubiquitination at Lys86, Lys91, Lys101, Lys118, Lys125, Lys130, Lys232, Lys155, Lys169, and Lys271
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPAB Gene

Domains for HNRNPAB Gene

Gene Families for HNRNPAB Gene

  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for HNRNPAB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q99729
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPAB: view

Function for HNRNPAB Gene

Molecular function for HNRNPAB Gene

UniProtKB/Swiss-Prot Function:
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site

Gene Ontology (GO) - Molecular Function for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003700 contributes_to sequence-specific DNA binding transcription factor activity ISS --
GO:0003723 RNA binding TAS 1717314
GO:0003729 mRNA binding TAS 8999813
genes like me logo Genes that share ontologies with HNRNPAB: view
genes like me logo Genes that share phenotypes with HNRNPAB: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPAB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPAB Gene

Localization for HNRNPAB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPAB Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

Jensen Localization Image for HNRNPAB Gene COMPARTMENTS Subcellular localization image for HNRNPAB gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm ISS --
GO:0030529 ribonucleoprotein complex IDA 17289661
GO:0090575 RNA polymerase II transcription factor complex ISS --
genes like me logo Genes that share ontologies with HNRNPAB: view

Pathways for HNRNPAB Gene

genes like me logo Genes that share pathways with HNRNPAB: view

Pathways by source for HNRNPAB Gene

1 Qiagen pathway for HNRNPAB Gene
1 BioSystems pathway for HNRNPAB Gene

Gene Ontology (GO) - Biological Process for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001837 epithelial to mesenchymal transition ISS --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with HNRNPAB: view

Transcripts for HNRNPAB Gene

Unigene Clusters for HNRNPAB Gene

Heterogeneous nuclear ribonucleoprotein A/B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPAB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPAB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP2: -
SP5: - - - -

Relevant External Links for HNRNPAB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HNRNPAB Gene

mRNA expression in normal human tissues for HNRNPAB Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPAB Gene

SOURCE GeneReport for Unigene cluster for HNRNPAB Gene Hs.591731

mRNA Expression by UniProt/SwissProt for HNRNPAB Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with HNRNPAB: view

Expression partners for HNRNPAB Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for HNRNPAB Gene

Orthologs for HNRNPAB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPAB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HNRNPAB 35
  • 91.11 (n)
  • 95.83 (a)
  • 96 (a)
(Mus musculus)
Mammalia Hnrnpab 35
  • 88.38 (n)
  • 91.13 (a)
Hnrnpab 16
Hnrnpab 36
  • 92 (a)
(Rattus norvegicus)
Mammalia LOC100910156 35
  • 88.89 (n)
  • 91.74 (a)
(Canis familiaris)
Mammalia HNRNPAB 36
  • 90 (a)
(Monodelphis domestica)
Mammalia HNRNPAB 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia HNRNPAB 36
  • 87 (a)
(Pan troglodytes)
Mammalia HNRNPAB 36
  • 100 (a)
(Gallus gallus)
  • 77.65 (n)
  • 84.67 (a)
  • 87 (a)
(Anolis carolinensis)
Reptilia HNRNPAB 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpab 35
  • 71.34 (n)
  • 76.55 (a)
African clawed frog
(Xenopus laevis)
Amphibia hnrpab-prov 35
(Danio rerio)
Actinopterygii Dr.18836 35
hnrnpabb 35
  • 69.83 (n)
  • 72.99 (a)
hnrnpaba 36
  • 67 (a)
hnrnpabb 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta sqd 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10292 36
  • 40 (a)
CSA.5495 36
  • 40 (a)
Species with no ortholog for HNRNPAB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPAB Gene

Gene Tree for HNRNPAB (if available)
Gene Tree for HNRNPAB (if available)

Paralogs for HNRNPAB Gene

Paralogs for HNRNPAB Gene Pseudogenes for HNRNPAB Gene

genes like me logo Genes that share paralogs with HNRNPAB: view

Variants for HNRNPAB Gene

Sequence variations from dbSNP and Humsavar for HNRNPAB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1131347 -- 178,206,812(+) CCGGT(C/G)AAGAA synonymous-codon, reference
rs2115053 -- 178,202,558(+) GAACC(C/T)GGGAG upstream-variant-2KB
rs2913753 -- 178,204,307(-) GCGCC(A/G)GGTCC upstream-variant-2KB
rs2913817 -- 178,203,039(+) CCTTG(A/G)GGCCC upstream-variant-2KB
rs2961673 -- 178,202,800(+) GTGAT(C/G)GTGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HNRNPAB Gene

Variant ID Type Subtype PubMed ID
nsv820182 CNV Gain 19587683

Relevant External Links for HNRNPAB Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPAB Gene

Disorders for HNRNPAB Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HNRNPAB Gene in MalaCards »

(2) Diseases for HNRNPAB Gene including...

genes like me logo Genes that share disorders with HNRNPAB: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HNRNPAB Gene

Publications for HNRNPAB Gene

  1. Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. (PMID: 8999813) Lau P.P. … Chan L. (J. Biol. Chem. 1997) 3 4 23
  2. Cloning and sequence analysis of a human type A/B hnRNP protein. (PMID: 1717314) Khan F. … Szer W. (FEBS Lett. 1991) 2 3 4
  3. P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome. (PMID: 12692135) Fomenkov A. … Ratovitski E. (J. Biol. Chem. 2003) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HNRNPAB Gene

Sources for HNRNPAB Gene

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