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Aliases for HNRNPAB Gene

Aliases for HNRNPAB Gene

  • Heterogeneous Nuclear Ribonucleoprotein A/B 2 3 5
  • APOBEC1-Binding Protein 1 3 4
  • HnRNP A/B 3 4
  • HNRPAB 3 4
  • ABBP-1 3 4
  • ABBP1 3 4
  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 1-Binding Protein 1 3
  • Apobec-1 Binding Protein 1 3
  • HnRNP Type A/B Protein 3

External Ids for HNRNPAB Gene

Previous HGNC Symbols for HNRNPAB Gene

  • HNRPAB

Previous GeneCards Identifiers for HNRNPAB Gene

  • GC05P177565
  • GC05P177631
  • GC05P172357

Summaries for HNRNPAB Gene

Entrez Gene Summary for HNRNPAB Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPAB Gene

HNRNPAB (Heterogeneous Nuclear Ribonucleoprotein A/B) is a Protein Coding gene. Diseases associated with HNRNPAB include Hay-Wells Syndrome and Wells Syndrome. Among its related pathways are mRNA Splicing - Major Pathway and Telomere Extension by Telomerase. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is HNRNPD.

UniProtKB/Swiss-Prot for HNRNPAB Gene

  • Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

Gene Wiki entry for HNRNPAB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPAB Gene

Genomics for HNRNPAB Gene

Regulatory Elements for HNRNPAB Gene

Enhancers for HNRNPAB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F178220 0.9 FANTOM5 ENCODE 26.5 +20.0 20041 8.6 CTCF KLF1 TEAD4 ZIC2 ZNF121 GLIS2 POLR2A SCRT2 PRDM10 ZNF548 HNRNPAB ZNF354C ZNF354B ZNF879 RPL21P60 ZFP2 ZNF454 LOC100130798 RMND5B COL23A1
GH05F178203 0.2 ENCODE 16.3 +5.3 5322 12.1 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZFP2 LOC100130798 ZNF454 ZNF879 ENSG00000247679 ZNF354C ZNF354B HNRNPAB LOC202181 CLK4
GH05F177350 0.6 ENCODE 12.2 -853.2 -853167 2.5 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FAF2 ZNF346 ZNF346-IT1 ENSG00000247679 RGS14 HNRNPAB LOC202181 LMAN2 RPS20P17
GH05F177507 0.8 ENCODE 12.2 -694.7 -694650 4.8 HDGF PKNOX1 WRNIP1 ZNF121 GLIS2 GATA2 TBX21 SMARCA4 MYNN KDM1A LOC105377750 DOK3 HNRNPAB PDLIM7 DDX41
GH05F177476 0.2 ENCODE 12.2 -725.7 -725714 3.7 NFRKB ZNF76 ARID4B RARA SCRT2 EGR2 SMARCA5 ZNF362 CEBPB REST HNRNPAB PRR7 FGFR4 ENSG00000279821 PIR32965
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HNRNPAB on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPAB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001298048 394 2600 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for HNRNPAB Gene

Chromosome:
5
Start:
178,204,507 bp from pter
End:
178,211,183 bp from pter
Size:
6,677 bases
Orientation:
Plus strand

Genomic View for HNRNPAB Gene

Genes around HNRNPAB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPAB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPAB Gene

Proteins for HNRNPAB Gene

  • Protein details for HNRNPAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99729-ROAA_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A/B
    Protein Accession:
    Q99729
    Secondary Accessions:
    • B3KNN5
    • D3DWP7
    • Q04150
    • Q8N7U3
    • Q9BQ99

    Protein attributes for HNRNPAB Gene

    Size:
    332 amino acids
    Molecular mass:
    36225 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APOBEC1.
    SequenceCaution:
    • Sequence=AAC50956.1; Type=Frameshift; Positions=296, 307, 330; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPAB Gene

    Alternative splice isoforms for HNRNPAB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPAB Gene

Post-translational modifications for HNRNPAB Gene

  • Dimethylation at Arg-322 is probably asymmetric.
  • Ubiquitination at Lys 86, Lys 91, Lys 101, Lys 118, Lys 125, Lys 130, Lys 232, Lys 155, Lys 169, and Lys 271
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPAB Gene

No data available for DME Specific Peptides for HNRNPAB Gene

Domains & Families for HNRNPAB Gene

Gene Families for HNRNPAB Gene

Suggested Antigen Peptide Sequences for HNRNPAB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99729

UniProtKB/Swiss-Prot:

ROAA_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPAB: view

Function for HNRNPAB Gene

Molecular function for HNRNPAB Gene

UniProtKB/Swiss-Prot Function:
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

Gene Ontology (GO) - Molecular Function for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003700 contributes_to transcription factor activity, sequence-specific DNA binding ISS --
GO:0003723 RNA binding TAS 1717314
GO:0003729 mRNA binding TAS 8999813
genes like me logo Genes that share ontologies with HNRNPAB: view
genes like me logo Genes that share phenotypes with HNRNPAB: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPAB Gene

Localization for HNRNPAB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPAB Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPAB Gene COMPARTMENTS Subcellular localization image for HNRNPAB gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,ISS --
GO:0030529 intracellular ribonucleoprotein complex IDA 17289661
GO:0090575 RNA polymerase II transcription factor complex ISS --
genes like me logo Genes that share ontologies with HNRNPAB: view

Pathways & Interactions for HNRNPAB Gene

genes like me logo Genes that share pathways with HNRNPAB: view

Pathways by source for HNRNPAB Gene

1 BioSystems pathway for HNRNPAB Gene
1 Qiagen pathway for HNRNPAB Gene

Gene Ontology (GO) - Biological Process for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001837 epithelial to mesenchymal transition ISS --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with HNRNPAB: view

No data available for SIGNOR curated interactions for HNRNPAB Gene

Transcripts for HNRNPAB Gene

Unigene Clusters for HNRNPAB Gene

Heterogeneous nuclear ribonucleoprotein A/B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPAB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3:
SP4:
SP5: - - - -

Relevant External Links for HNRNPAB Gene

GeneLoc Exon Structure for
HNRNPAB
ECgene alternative splicing isoforms for
HNRNPAB

Expression for HNRNPAB Gene

mRNA expression in normal human tissues for HNRNPAB Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPAB Gene



Protein tissue co-expression partners for HNRNPAB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPAB Gene:

HNRNPAB

SOURCE GeneReport for Unigene cluster for HNRNPAB Gene:

Hs.591731

mRNA Expression by UniProt/SwissProt for HNRNPAB Gene:

Q99729-ROAA_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with HNRNPAB: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for HNRNPAB Gene

Orthologs for HNRNPAB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPAB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPAB 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HNRNPAB 34 35
  • 91.11 (n)
dog
(Canis familiaris)
Mammalia HNRNPAB 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910156 34
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Hnrnpab 34 16 35
  • 88.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPAB 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPAB 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPAB 34 35
  • 77.65 (n)
lizard
(Anolis carolinensis)
Reptilia HNRNPAB 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpab 34
  • 71.34 (n)
African clawed frog
(Xenopus laevis)
Amphibia hnrpab-prov 34
zebrafish
(Danio rerio)
Actinopterygii hnrnpabb 34 35
  • 69.83 (n)
hnrnpaba 35
  • 67 (a)
OneToMany
Dr.18836 34
fruit fly
(Drosophila melanogaster)
Insecta sqd 35
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10292 35
  • 40 (a)
ManyToMany
CSA.5495 35
  • 40 (a)
ManyToMany
Species where no ortholog for HNRNPAB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPAB Gene

ENSEMBL:
Gene Tree for HNRNPAB (if available)
TreeFam:
Gene Tree for HNRNPAB (if available)

Paralogs for HNRNPAB Gene

Pseudogenes.org Pseudogenes for HNRNPAB Gene

genes like me logo Genes that share paralogs with HNRNPAB: view

Variants for HNRNPAB Gene

Sequence variations from dbSNP and Humsavar for HNRNPAB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10061499 -- 178,203,266(+) cggct(C/T)actgc upstream-variant-2KB
rs10066437 -- 178,203,260(+) agatc(A/G/T)cggct upstream-variant-2KB
rs10408 -- 178,211,122(+) ATATT(C/G)AAGCT intron-variant, utr-variant-3-prime
rs1050988 -- 178,211,108(+) TTGCC(A/C)CAACC intron-variant, utr-variant-3-prime
rs10586409 -- 178,203,809(+) CCATC(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HNRNPAB Gene

Variant ID Type Subtype PubMed ID
dgv1679e212 CNV loss 25503493
nsv1017664 CNV gain 25217958
nsv1019404 CNV gain 25217958
nsv1120062 OTHER inversion 24896259
nsv1144126 CNV deletion 24896259
nsv820182 CNV gain 19587683

Variation tolerance for HNRNPAB Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPAB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPAB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPAB Gene

Disorders for HNRNPAB Gene

MalaCards: The human disease database

(2) MalaCards diseases for HNRNPAB Gene - From: GeneCards

Disorder Aliases PubMed IDs
hay-wells syndrome
  • aec syndrome
wells syndrome
  • bullous cellulitis with eosinophilia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HNRNPAB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPAB
genes like me logo Genes that share disorders with HNRNPAB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPAB Gene

Publications for HNRNPAB Gene

  1. Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. (PMID: 8999813) Lau P.P. … Chan L. (J. Biol. Chem. 1997) 3 4 22 64
  2. Cloning and sequence analysis of a human type A/B hnRNP protein. (PMID: 1717314) Khan F. … Szer W. (FEBS Lett. 1991) 2 3 4 64
  3. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Joeson L. … Nielsen F.C. (Mol. Cell. Proteomics 2007) 3 4 64
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for HNRNPAB Gene

Sources for HNRNPAB Gene

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