Aliases for HNRNPAB Gene
Aliases for HNRNPAB Gene
External Ids for HNRNPAB Gene
- HGNC: 5034
- Entrez Gene: 3182
- Ensembl: ENSG00000197451
- OMIM: 602688
- UniProtKB: Q99729
Previous HGNC Symbols for HNRNPAB Gene
- HNRPAB
Previous GeneCards Identifiers for HNRNPAB Gene
- GC05P177565
- GC05P177631
- GC05P172357
Summaries for HNRNPAB Gene
-
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNRNPAB Gene
HNRNPAB (Heterogeneous Nuclear Ribonucleoprotein A/B) is a Protein Coding gene. Diseases associated with HNRNPAB include Hay-Wells Syndrome and Wells Syndrome. Among its related pathways are mRNA Splicing - Major Pathway and Preimplantation Embryo. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is HNRNPD.
UniProtKB/Swiss-Prot for HNRNPAB Gene
-
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPAB Gene
Genomics for HNRNPAB Gene
Regulatory Elements for HNRNPAB Gene
Enhancers for HNRNPAB Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HNRNPAB on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HNRNPAB Gene
- Chromosome:
- 5
- Start:
- 178,204,507 bp from pter
- End:
- 178,211,183 bp from pter
- Size:
- 6,677 bases
- Orientation:
- Plus strand
Genomic View for HNRNPAB Gene
Genes around HNRNPAB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.3 by Ensembl
- 5q35.3 by Entrez Gene
- 5q35.3 by HGNC
HNRNPAB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPAB Gene
Proteins for HNRNPAB Gene
-
Protein details for HNRNPAB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99729-ROAA_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoprotein A/B
- Protein Accession:
- Q99729
- B3KNN5
- D3DWP7
- Q04150
- Q8N7U3
- Q9BQ99
Protein attributes for HNRNPAB Gene
- Size:
- 332 amino acids
- Molecular mass:
- 36225 Da
- Quaternary structure:
-
- Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APOBEC1.
- SequenceCaution:
-
- Sequence=AAC50956.1; Type=Frameshift; Positions=296, 307, 330; Evidence={ECO:0000305};
Protein Expression for HNRNPAB Gene
Post-translational modifications for HNRNPAB Gene
- Dimethylation at Arg-322 is probably asymmetric.
- Ubiquitination at isoforms=2, 3, 486, posLast=9191, isoforms=2, 3, 4101, isoforms=2, 3, 4118, isoforms=2, 3, 4125, isoforms=2, 3, 4130, posLast=232232, isoforms=3155, isoforms=3169, and isoforms=4271
- Modification sites at PhosphoSitePlus
Other Protein References for HNRNPAB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HNRNPAB
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- antibodies-online Antibodies for HNRNPAB: See all 31
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-
Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPAB
Protein Products
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- antibodies-online Proteins for HNRNPAB: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HNRNPAB
Assay Products
- antibodies-online Kits for HNRNPAB: See all 18
No data available for DME Specific Peptides for HNRNPAB Gene
Domains & Families for HNRNPAB Gene
Gene Families for HNRNPAB Gene
Protein Domains for HNRNPAB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPAB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HNRNPAB Gene
Function for HNRNPAB Gene
Molecular function for HNRNPAB Gene
- UniProtKB/Swiss-Prot Function:
- Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003700 | contributes_to transcription factor activity, sequence-specific DNA binding | ISS | -- |
| GO:0003723 | RNA binding | TAS,IDA | 22658674 |
| GO:0003729 | mRNA binding | TAS | 8999813 |
| GO:0005515 | protein binding | IPI | 24965446 |
Phenotypes for HNRNPAB Gene
- MGI mutant phenotypes for HNRNPAB:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HNRNPAB:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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ViGene Biosciences lentiviral particle packaged cDNA for HNRNPAB gene
-
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CRISPR Products
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OriGene CRISPR knockouts for HNRNPAB
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPAB
- GenScript: Design CRISPR guide RNA sequences for HNRNPAB
miRNA for HNRNPAB Gene
- miRTarBase miRNAs that target HNRNPAB
-
- hsa-mir-1260a (MIRT035853)
- hsa-mir-615-3p (MIRT039743)
- hsa-mir-504-5p (MIRT041080)
- hsa-mir-193b-3p (MIRT041499)
- hsa-mir-149-5p (MIRT045420)
- hsa-mir-181a-5p (MIRT047321)
- hsa-mir-625-5p (MIRT238509)
- hsa-mir-1275 (MIRT238510)
- hsa-mir-4665-5p (MIRT238514)
- hsa-mir-141-3p (MIRT313183)
- hsa-mir-200a-3p (MIRT313184)
- hsa-mir-545-5p (MIRT313185)
- hsa-mir-548k (MIRT313186)
- hsa-mir-548n (MIRT313187)
- hsa-mir-548av-5p (MIRT313188)
- hsa-mir-8054 (MIRT313189)
- hsa-mir-34a-3p (MIRT358520)
- hsa-mir-492 (MIRT358522)
- hsa-mir-548c-3p (MIRT358523)
- hsa-mir-631 (MIRT358525)
- hsa-mir-637 (MIRT358526)
- hsa-mir-3144-5p (MIRT358527)
- hsa-mir-3649 (MIRT358528)
- hsa-mir-3661 (MIRT358529)
- hsa-mir-4490 (MIRT358530)
- hsa-mir-4641 (MIRT358532)
- hsa-mir-4690-3p (MIRT358533)
- hsa-mir-5685 (MIRT358534)
- hsa-mir-4314 (MIRT562185)
- hsa-mir-5010-5p (MIRT562186)
- hsa-mir-4525 (MIRT562187)
- hsa-mir-7111-5p (MIRT562188)
- hsa-mir-6870-5p (MIRT562189)
- hsa-mir-5698 (MIRT562190)
- hsa-mir-4723-5p (MIRT562191)
- hsa-mir-7155-5p (MIRT562192)
- hsa-mir-8089 (MIRT562193)
- hsa-mir-4700-5p (MIRT562194)
- hsa-mir-4667-5p (MIRT562195)
- hsa-mir-652-3p (MIRT562196)
- hsa-mir-4282 (MIRT567290)
- hsa-mir-101-3p (MIRT567291)
- hsa-mir-144-3p (MIRT567292)
miRNA Products
- Search ViGene Biosciences for HNRNPAB
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HNRNPAB
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-
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for HNRNPAB
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPAB Gene
Localization for HNRNPAB Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPAB Gene
- Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS,IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | ISS,IEA | -- |
| GO:0030529 | intracellular ribonucleoprotein complex | IDA | 17289661 |
| GO:0090575 | RNA polymerase II transcription factor complex | ISS | -- |
Pathways & Interactions for HNRNPAB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Telomere Extension by Telomerase | ||
| 2 | mRNA Splicing - Major Pathway |
.41
|
|
| 3 | Preimplantation Embryo | ||
Pathways by source for HNRNPAB Gene
2 BioSystems pathways for HNRNPAB Gene
1 Qiagen pathway for HNRNPAB Gene
Interacting Proteins for HNRNPAB Gene
Selected Interacting proteins:
ENSP00000351108
Q99729-ROAA_HUMAN
for HNRNPAB Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001837 | epithelial to mesenchymal transition | ISS | -- |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISS | -- |
No data available for SIGNOR curated interactions for HNRNPAB Gene
Transcripts for HNRNPAB Gene
mRNA/cDNA for HNRNPAB Gene
- (2) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (647) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HNRNPAB Gene
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPAB
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPAB
- GenScript: Design CRISPR guide RNA sequences for HNRNPAB
miRNA Products
- Search ViGene Biosciences for HNRNPAB
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HNRNPAB
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-
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Clone Products
- Sino Biological Human cDNA Clone for HNRNPAB
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - |
Expression for HNRNPAB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPAB Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HNRNPAB Gene:
HNRNPABSOURCE GeneReport for Unigene cluster for HNRNPAB Gene:
Hs.591731mRNA Expression by UniProt/SwissProt for HNRNPAB Gene:
Q99729-ROAA_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for HNRNPAB Gene
- Skin(4.6)
- Liver(4.4)
- Nervous system(4.2)
- Lung(3)
- Intestine(2.6)
Primer Products
-
OriGene qPCR primer pairs for HNRNPAB
-
OriGene qPCR primer pairs and template standards for HNRNPAB
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPAB Gene
Orthologs for HNRNPAB Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HNRNPAB 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HNRNPAB 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HNRNPAB 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | LOC100910156 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hnrnpab 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HNRNPAB 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HNRNPAB 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HNRNPAB 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HNRNPAB 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hnrnpab 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | hnrpab-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hnrnpabb 34 35 |
|
||
| hnrnpaba 35 |
|
OneToMany | |||
| Dr.18836 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | sqd 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HRP1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10292 35 |
|
ManyToMany | |
| CSA.5495 35 |
|
ManyToMany |
- Species where no ortholog for HNRNPAB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HNRNPAB Gene
Paralogs for HNRNPAB Gene
(17) SIMAP similar genes for HNRNPAB Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for HNRNPAB Gene
Variants for HNRNPAB Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000294138 | -- | 178,210,965(+) | ACCAG(C/T)GTCAC | intron-variant, utr-variant-3-prime | |
| rs1000559336 | -- | 178,210,000(+) | CACCA(A/G)AACAG | intron-variant | |
| rs1000899703 | -- | 178,211,555(+) | AGCCT(G/T)CTCTG | intron-variant, downstream-variant-500B | |
| rs1001508270 | -- | 178,204,396(+) | CTAGA(-/GCGC)GCGCG | upstream-variant-2KB | |
| rs1001636041 | -- | 178,208,764(+) | TTATT(C/G)CAACA | intron-variant, nc-transcript-variant, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1679e212 | CNV | loss | 25503493 |
| nsv1017664 | CNV | gain | 25217958 |
| nsv1019404 | CNV | gain | 25217958 |
| nsv1120062 | OTHER | inversion | 24896259 |
| nsv1144126 | CNV | deletion | 24896259 |
| nsv820182 | CNV | gain | 19587683 |
Residual Variation Intolerance Score:
35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.77;
16.18% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HNRNPAB Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HNRNPAB
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPAB Gene
Disorders for HNRNPAB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hay-wells syndrome |
|
|
| wells syndrome |
|
|
Search HNRNPAB in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HNRNPAB
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HNRNPAB
No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPAB Gene
Publications for HNRNPAB Gene
- Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. (PMID: 8999813) Lau P.P. … Chan L. (J. Biol. Chem. 1997) 3 4 22 64
- Cloning and sequence analysis of a human type A/B hnRNP protein. (PMID: 1717314) Khan F. … Szer W. (FEBS Lett. 1991) 2 3 4 64
- Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Joeson L. … Nielsen F.C. (Mol. Cell. Proteomics 2007) 3 4 64
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
Products for HNRNPAB Gene
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- antibodies-online Antibodies for HNRNPAB: See all 31
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- antibodies-online Proteins for HNRNPAB: See all 8
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- ViGene Biosciences adenoviral particle packaged cDNA for HNRNPAB gene
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- VectorBuilder custom plasmid, inducible vectors for HNRNPAB
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HNRNPAB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
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