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HNRNPAB Gene

protein-coding   GIFtS: 55
GCID: GC05P177631

Heterogeneous Nuclear Ribonucleoprotein A/B


(Previous symbol: HNRPAB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Heterogeneous Nuclear Ribonucleoprotein A/B1 2     HnRNP A/B2 3
HNRPAB1 2 3     Apobec-1 Binding Protein 12
ABBP-12 3     Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 1-Binding
Protein 12
ABBP12 3     HnRNP Type A/B Protein2
APOBEC1-Binding Protein 12 3     

External Ids:    HGNC: 50341   Entrez Gene: 31822   Ensembl: ENSG000001974517   OMIM: 6026885   UniProtKB: Q997293   
ORGUL members:         

Export aliases for HNRNPAB gene to outside databases

Previous GC identifers: GC05P177565 GC05P172357


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPAB Gene:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA)
complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and
other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to
shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.
The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has
two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript
variants encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for HNRNPAB Gene:
HNRNPAB (heterogeneous nuclear ribonucleoprotein A/B) is a protein-coding gene. Diseases associated with HNRNPAB include wells syndrome, and cystic fibrosis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HNRNPA1.

UniProtKB/Swiss-Prot: ROAA_HUMAN, Q99729
Function: Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to
APOB mRNA transcripts around the RNA editing site

Gene Wiki entry for HNRNPAB (HNRPAB) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPAB gene promoter:
         Nkx2-5   CBF-C   CREB   CBF-A   CBF-B   deltaCREB   CP1C   CP1A   NF-Y   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HNRNPAB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPAB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

HNRNPAB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPAB gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P177631:  view genomic region     (about GC identifiers)

Start:
177,631,508 bp from pter      End:
177,638,184 bp from pter
Size:
6,677 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ROAA_HUMAN, Q99729 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein A/B  
Size: 332 amino acids; 36225 Da
Subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with
APOBEC1
Sequence caution: Sequence=AAC50956.1; Type=Frameshift; Positions=296, 307, 330;
1 PDB 3D structure from and Proteopedia for HNRNPAB:
3S7R (3D)    
Secondary accessions: B3KNN5 D3DWP7 Q04150 Q8N7U3 Q9BQ99
Alternative splicing: 4 isoforms:  Q99729-1   Q99729-2   Q99729-3   Q99729-4   (Ref.1 (AAA36575) sequence differs from that shown due to several frameshifts. Contains a N6-acetyllysine at position 272. Contains a phosphoserine at position 256)

Explore the universe of human proteins at neXtProt for HNRNPAB: NX_Q99729

Explore proteomics data for HNRNPAB at MOPED

Post-translational modifications: 

  • Dimethylation at Arg-322 is probably asymmetric1
  • Ubiquitination2 at Lys86, Lys91, Lys101, Lys118, Lys125, Lys130, Lys232
  • Modification sites at PhosphoSitePlus

  • See HNRNPAB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004490.2  NP_112556.2  

    ENSEMBL proteins: 
     ENSP00000351108   ENSP00000422501   ENSP00000348093   ENSP00000427110   ENSP00000423495  
     ENSP00000427465   ENSP00000425031  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012956 CARG-binding_factor_N
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q99729

    ProtoNet protein and cluster: Q99729

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB012956 CBF


    UniProtKB/Swiss-Prot: ROAA_HUMAN, Q99729
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    HNRNPAB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROAA_HUMAN, Q99729
    Function: Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to
    APOB mRNA transcripts around the RNA editing site

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003700contributes to sequence-specific DNA binding transcription factor activity ISS--
    GO:0003723RNA binding TAS1717314
    GO:0003729mRNA binding TAS8999813
         
    HNRNPAB for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HNRNPAB:
     Decreased Hepatitis C virus re  Decreased viability of wild-ty  Synthetic lethal with c-Myc af 

    Animal Models:
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    Block miRNA regulation of human, mouse, rat HNRNPAB using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate HNRNPAB:
    hsa-miR-548m hsa-miR-3163 hsa-miR-1197 hsa-miR-376a* hsa-miR-548k hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPAB 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ROAA_HUMAN, Q99729: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated
    mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0030529ribonucleoprotein complex IDA17289661

    HNRNPAB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPAB About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HNRNPAB
        Telomere Extension by Telomerase

    1 BioSystems Pathway for HNRNPAB
        mRNA processing



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPAB
    Interactions:

        GeneGlobe Interaction Network for HNRNPAB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPAB (Q997292, 3 ENSP000003511084) via UniProtKB, MINT, STRING, and/or I2D (see all 711)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607092, 3, ENSP000003499604MINT-7945693 I2D: score=2 STRING: ENSP00000349960
    SF3A2Q154282, 3, ENSP000002214944MINT-5205818 I2D: score=1 STRING: ENSP00000221494
    NSFP464592, 3MINT-7945693 I2D: score=1 
    SQSTM1Q135012, 3MINT-7945693 I2D: score=1 
    SYNCRIPO605062, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001837epithelial to mesenchymal transition ISS--
    GO:0045893positive regulation of transcription, DNA-templated ISS--

    HNRNPAB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPAB (ROAA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HNRNPAB gene (2 alternative transcripts): 
    NM_004499.3  NM_031266.2  

    Unigene Cluster for HNRNPAB:

    Heterogeneous nuclear ribonucleoprotein A/B
    Hs.591731  [show with all ESTs]
    Unigene Representative Sequence: NM_031266
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358344(uc003miu.3 uc003miv.3) ENST00000506339 ENST00000355836
    ENST00000514633 ENST00000515193 ENST00000506259(uc003mix.3) ENST00000504898
    ENST00000504796
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate HNRNPAB:
    hsa-miR-548m hsa-miR-3163 hsa-miR-1197 hsa-miR-376a* hsa-miR-548k hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPAB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HNRNPAB
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      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPAB
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    Additional mRNA sequence: 

    AK054600.1 AK097657.1 AK223425.1 BC001616.1 BC002625.2 BC004561.2 BC009359.2 BC015556.2 
    BC036708.2 M65028.1 U76713.1 Z36844.1 

    23 DOTS entries:

    DT.446996  DT.100839425  DT.100839434  DT.91762877  DT.100839418  DT.100839441  DT.120839439  DT.100044721 
    DT.120839602  DT.40287340  DT.120839512  DT.95184714  DT.121137298  DT.100839440  DT.120839523  DT.120839610 
    DT.95235931  DT.100044720  DT.120839530  DT.120839552  DT.446995  DT.100682262  DT.95184703 

    Selected AceView cDNA sequences (see all 647):

    CA428839 BQ923791 AA827225 BQ068738 CR610544 BM997583 BQ940610 BM853528 
    BC002625 BC004561 BF969266 BQ955207 AI199152 BC036708 BE390276 CR610666 
    CR602810 BG284592 CR619967 CR617383 CR610440 BQ430329 BM905769 BM557957 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPAB    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                                                                            
    SP2:                                                                                            -               
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                          -     -     -     -                                                               


    ECgene alternative splicing isoforms for HNRNPAB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPAB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGATTTT
    HNRNPAB Expression
    About this image


    HNRNPAB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Septum   
    HNRNPAB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPAB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591731

    UniProtKB/Swiss-Prot: ROAA_HUMAN, Q99729
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPAB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HNRNPAB gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpab1 , 5 heterogeneous nuclear ribonucleoprotein A/B1, 5 88.38(n)1
    91.13(a)1
      11 (31.11 cM)5
    153841  NM_001048061.11  NP_001041526.11 
     516001005 
    chicken
    (Gallus gallus)
    Aves HNRNPAB1 heterogeneous nuclear ribonucleoprotein A/B 77.65(n)
    84.67(a)
      396268  NM_205328.5  NP_990659.1 
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPAB6
    heterogeneous nuclear ribonucleoprotein A/B
    72(a)
    1 ↔ 1
    2(142037696-142045439)
    African clawed frog
    (Xenopus laevis)
    Amphibia hnrpab-prov2 heterogeneous nuclear ribonucleoprotein A/B 82.16(n)    BC043814.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.188362 Danio rerio mRNA similar to heterogeneous nuclear ribonucleoprotein more 78.91(n)    BC048898.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sqd6
    squid
    36(a)
    1 → many
    3R(9460679-9472026)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRP16
    Subunit of cleavage factor I, a five-subunit compl...
    22(a)
    1 → many
    XV(87844-89448) YOL123W


    ENSEMBL Gene Tree for HNRNPAB (if available)
    TreeFam Gene Tree for HNRNPAB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPAB gene
    HNRNPA12  HNRNPD2  HNRNPDL2  HNRNPA32  HNRNPA02  HNRNPA1L22  HNRNPA2B12  
    17 SIMAP similar genes for HNRNPAB using alignment to 4 protein entries:     ROAA_HUMAN (see all proteins):
    HNRNPDL    HNRNPD    HNRNPA2B1    HNRPA1    HNRNPA1L2    HNRPA3
    MSI2    HNRNPA1    HNRNPA3    D10S102    MSI1    SLIRP
    HNRNPA0    DAZAP1    RBMY1A1    CIRBP    RBM38

    HNRNPAB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HNRNPAB
    PGOHUM00000239668


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPAB (see all 175)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391365661,2
    C--172355830(+) TGTTAG/TGGAAT 2 -- us2k10--------
    rs1165920171,2
    C,F--172355931(+) TTTGGG/TGGAAG 2 -- us2k11Minor allele frequency- T:0.05NA 120
    rs1435077591,2
    C--172355991(+) CACGT-/TATCTT 2 -- us2k10--------
    rs49767141,2
    C,F--172356071(+) GGGCCG/ACTGCT 2 -- us2k13Minor allele frequency- A:0.08WA NA EA 358
    rs1895279241,2
    --172356086(+) ACTTCA/CGTTTT 2 -- us2k10--------
    rs49767151,2
    C--177629543(+) GGCAGA/GAGAAT 2 -- us2k10--------
    rs21150531,2
    C,A,H--177629559(+) GAACCC/TGGGAG 2 -- us2k17Minor allele frequency- T:0.00NA WA CSA 13
    rs348313571,2
    C--177629640(+) CAAAG-/AAAAAA 2 -- us2k12Minor allele frequency- A:0.00NA CSA 4
    rs1408212051,2
    C--177629661(+) GATCTA/GGCTGG 2 -- us2k10--------
    rs1173564841,2
    F--177629676(+) CATAGG/AGAGAC 2 -- us2k11Minor allele frequency- A:0.01EA 120

    HapMap Linkage Disequilibrium report for HNRNPAB (177631508 - 177638184 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HNRNPAB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820182CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPAB
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPAB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602688    OMIM disorders: --

    14 diseases for HNRNPAB:    
    About MalaCards
    wells syndrome    cystic fibrosis    pancreatic cancer    pancreatitis
    hepatocellular carcinoma    hiv-1    neuroblastoma    endotheliitis
    multiple myeloma    breast cancer    myeloma    cerebritis
    malaria    neuronitis


    HNRNPAB for disorders           About GeneDecksing


    Export disorders for HNRNPAB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPAB gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with HNRNPAB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequence analysis of a human type A/B hnRNP protein. (PubMed id 1717314)1, 2, 3 Khan F.... Szer W. (FEBS Lett. 1991)
    2. Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. (PubMed id 8999813)1, 2, 9 Lau P.P.... Chan L. (J. Biol. Chem. 1997)
    3. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)1, 2 Ong S.E.... Mann M. (Nat. Methods 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome. (PubMed id 12692135)1, 9 Fomenkov A....Ratovitski E. (J. Biol. Chem. 2003)
    9. An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19. (PubMed id 23500468)1 Velasco K....Lindsten K. (Biochem. Biophys. Res. Commun. 2013)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3182 HGNC: 5034 AceView: HNRPAB Ensembl:ENSG00000197451 euGenes: HUgn3182
    ECgene: HNRNPAB H-InvDB: HNRNPAB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HNRNPAB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPAB gene:
    Search GeneIP for patents involving HNRNPAB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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