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Aliases for HNRNPAB Gene

Aliases for HNRNPAB Gene

  • Heterogeneous Nuclear Ribonucleoprotein A/B 2 3 5
  • APOBEC1-Binding Protein 1 3 4
  • HnRNP A/B 3 4
  • HNRPAB 3 4
  • ABBP-1 3 4
  • ABBP1 3 4
  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 1-Binding Protein 1 3
  • Apobec-1 Binding Protein 1 3
  • HnRNP Type A/B Protein 3

External Ids for HNRNPAB Gene

Previous HGNC Symbols for HNRNPAB Gene

  • HNRPAB

Previous GeneCards Identifiers for HNRNPAB Gene

  • GC05P177565
  • GC05P177631
  • GC05P172357

Summaries for HNRNPAB Gene

Entrez Gene Summary for HNRNPAB Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPAB Gene

HNRNPAB (Heterogeneous Nuclear Ribonucleoprotein A/B) is a Protein Coding gene. Diseases associated with HNRNPAB include Hay-Wells Syndrome and Wells Syndrome. Among its related pathways are Telomere Extension by Telomerase and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is HNRNPD.

UniProtKB/Swiss-Prot for HNRNPAB Gene

  • Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

Gene Wiki entry for HNRNPAB Gene

Additional gene information for HNRNPAB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPAB Gene

Genomics for HNRNPAB Gene

Regulatory Elements for HNRNPAB Gene

Enhancers for HNRNPAB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H178220 1.3 FANTOM5 ENCODE dbSUPER 26.5 +20.0 20041 8 CTCF KLF1 SALL2 ZIC2 ZNF121 GLIS2 POLR2A SCRT2 PRDM10 ZNF548 HNRNPAB ZNF354B RPL21P60 ZNF354C FAM193B ENSG00000254035 RMND5B ZFP2 COL23A1 PHYKPL
GH05H178111 2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -84.4 -84390 16 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B ZNF766 ZNF143 ZNF207 NSD1 ENSG00000247679 ZNF879 ZNF354B LOC202181 CLK4 ZNF354C N4BP3 FAM193B RMND5B
GH05H177425 1.8 FANTOM5 ENCODE dbSUPER 9.9 -775.1 -775136 8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 CBX5 NSD1 GRK6 FAF2 UIMC1 DOK3 ENSG00000247679 LOC202181 ZNF346-IT1 PFN3 FAM193B
GH05H177443 1.6 Ensembl ENCODE dbSUPER 9.7 -758.1 -758144 6 HNRNPUL1 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF207 FOS NSD1 FAF2 UIMC1 ENSG00000248484 ZNF346 LOC105377752 OR1X5P LOC105377753 GMCL1P1 ENSG00000247679
GH05H177356 1.2 ENCODE dbSUPER 12.9 -846.0 -846017 3 HDGF RB1 SIN3A BMI1 ZBTB40 RAD21 YY1 ZNF143 ZNF207 ATF7 RGS14 PRELID1 MXD3 HNRNPAB SLC34A1 UIMC1 RAB24 FAM193B FAF2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HNRNPAB on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPAB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000191416 394 2600 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for HNRNPAB Gene

Chromosome:
5
Start:
178,204,507 bp from pter
End:
178,211,183 bp from pter
Size:
6,677 bases
Orientation:
Plus strand

Genomic View for HNRNPAB Gene

Genes around HNRNPAB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPAB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPAB Gene

Proteins for HNRNPAB Gene

  • Protein details for HNRNPAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99729-ROAA_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A/B
    Protein Accession:
    Q99729
    Secondary Accessions:
    • B3KNN5
    • D3DWP7
    • Q04150
    • Q8N7U3
    • Q9BQ99

    Protein attributes for HNRNPAB Gene

    Size:
    332 amino acids
    Molecular mass:
    36225 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APOBEC1.
    SequenceCaution:
    • Sequence=AAC50956.1; Type=Frameshift; Positions=296, 307, 330; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPAB Gene

    Alternative splice isoforms for HNRNPAB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPAB Gene

Post-translational modifications for HNRNPAB Gene

  • Dimethylation at Arg-322 is probably asymmetric.
  • Ubiquitination at isoforms=2, 3, 486, posLast=9191, posLast=101101, isoforms=2, 3, 4118, isoforms=2, 3, 4125, isoforms=2, 3, 4130, posLast=232232, posLast=155155, posLast=169169, and posLast=271271
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPAB Gene

No data available for DME Specific Peptides for HNRNPAB Gene

Domains & Families for HNRNPAB Gene

Gene Families for HNRNPAB Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HNRNPAB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPAB: view

No data available for UniProtKB/Swiss-Prot for HNRNPAB Gene

Function for HNRNPAB Gene

Molecular function for HNRNPAB Gene

UniProtKB/Swiss-Prot Function:
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

Phenotypes From GWAS Catalog for HNRNPAB Gene

Gene Ontology (GO) - Molecular Function for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 contributes_to transcription factor activity, sequence-specific DNA binding ISS --
GO:0003723 RNA binding IDA,TAS 22658674
GO:0003729 mRNA binding TAS 8999813
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with HNRNPAB: view
genes like me logo Genes that share phenotypes with HNRNPAB: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HNRNPAB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPAB Gene

Localization for HNRNPAB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPAB Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPAB gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm ISS --
GO:0030529 intracellular ribonucleoprotein complex IDA 17289661
GO:0090575 RNA polymerase II transcription factor complex ISS --
genes like me logo Genes that share ontologies with HNRNPAB: view

Pathways & Interactions for HNRNPAB Gene

genes like me logo Genes that share pathways with HNRNPAB: view

Pathways by source for HNRNPAB Gene

2 BioSystems pathways for HNRNPAB Gene
1 Qiagen pathway for HNRNPAB Gene

Gene Ontology (GO) - Biological Process for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001837 epithelial to mesenchymal transition ISS --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with HNRNPAB: view

No data available for SIGNOR curated interactions for HNRNPAB Gene

Drugs & Compounds for HNRNPAB Gene

No Compound Related Data Available

Transcripts for HNRNPAB Gene

Unigene Clusters for HNRNPAB Gene

Heterogeneous nuclear ribonucleoprotein A/B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HNRNPAB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPAB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3:
SP4:
SP5: - - - -

Relevant External Links for HNRNPAB Gene

GeneLoc Exon Structure for
HNRNPAB
ECgene alternative splicing isoforms for
HNRNPAB

Expression for HNRNPAB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPAB Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPAB Gene



Protein tissue co-expression partners for HNRNPAB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPAB Gene:

HNRNPAB

SOURCE GeneReport for Unigene cluster for HNRNPAB Gene:

Hs.591731

mRNA Expression by UniProt/SwissProt for HNRNPAB Gene:

Q99729-ROAA_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for HNRNPAB Gene

  • Skin(4.6)
  • Liver(4.4)
  • Nervous system(4.2)
  • Lung(3)
  • Intestine(2.6)
genes like me logo Genes that share expression patterns with HNRNPAB: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPAB Gene

Orthologs for HNRNPAB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPAB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPAB 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HNRNPAB 33 34
  • 91.11 (n)
dog
(Canis familiaris)
Mammalia HNRNPAB 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910156 33
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Hnrnpab 33 16 34
  • 88.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPAB 34
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPAB 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPAB 33 34
  • 77.65 (n)
lizard
(Anolis carolinensis)
Reptilia HNRNPAB 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpab 33
  • 71.34 (n)
African clawed frog
(Xenopus laevis)
Amphibia hnrpab-prov 33
zebrafish
(Danio rerio)
Actinopterygii hnrnpabb 33 34
  • 69.83 (n)
hnrnpaba 34
  • 67 (a)
OneToMany
Dr.18836 33
fruit fly
(Drosophila melanogaster)
Insecta sqd 34
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10292 34
  • 40 (a)
ManyToMany
CSA.5495 34
  • 40 (a)
ManyToMany
Species where no ortholog for HNRNPAB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPAB Gene

ENSEMBL:
Gene Tree for HNRNPAB (if available)
TreeFam:
Gene Tree for HNRNPAB (if available)

Paralogs for HNRNPAB Gene

Paralogs for HNRNPAB Gene

Pseudogenes.org Pseudogenes for HNRNPAB Gene

genes like me logo Genes that share paralogs with HNRNPAB: view

Variants for HNRNPAB Gene

Sequence variations from dbSNP and Humsavar for HNRNPAB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000294138 -- 178,210,965(+) ACCAG(C/T)GTCAC intron-variant, utr-variant-3-prime
rs1000559336 -- 178,210,000(+) CACCA(A/G)AACAG intron-variant
rs1000899703 -- 178,211,555(+) AGCCT(G/T)CTCTG intron-variant, downstream-variant-500B
rs1001508270 -- 178,204,396(+) CTAGA(-/GCGC)GCGCG upstream-variant-2KB
rs1001636041 -- 178,208,764(+) TTATT(C/G)CAACA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HNRNPAB Gene

Variant ID Type Subtype PubMed ID
dgv1679e212 CNV loss 25503493
nsv1017664 CNV gain 25217958
nsv1019404 CNV gain 25217958
nsv1120062 OTHER inversion 24896259
nsv1144126 CNV deletion 24896259
nsv820182 CNV gain 19587683

Variation tolerance for HNRNPAB Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPAB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPAB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPAB Gene

Disorders for HNRNPAB Gene

MalaCards: The human disease database

(2) MalaCards diseases for HNRNPAB Gene - From: GeneCards

Disorder Aliases PubMed IDs
hay-wells syndrome
  • ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
wells syndrome
  • bullous cellulitis with eosinophilia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HNRNPAB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPAB
genes like me logo Genes that share disorders with HNRNPAB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPAB Gene

Publications for HNRNPAB Gene

  1. Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. (PMID: 8999813) Lau PP … Chan L (The Journal of biological chemistry 1997) 3 4 22 60
  2. Cloning and sequence analysis of a human type A/B hnRNP protein. (PMID: 1717314) Khan FA … Szer W (FEBS letters 1991) 2 3 4 60
  3. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Jønson L … Nielsen FC (Molecular & cellular proteomics : MCP 2007) 3 4 60
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for HNRNPAB Gene

Sources for HNRNPAB Gene

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