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Aliases for HNRNPA3 Gene

Aliases for HNRNPA3 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A3 2 3 5
  • HnRNP A3 3 4
  • HNRPA3 3 4
  • 2610510D13Rik 3
  • D10S102 3
  • FBRNP 3

External Ids for HNRNPA3 Gene

Previous HGNC Symbols for HNRNPA3 Gene

  • HNRPA3

Previous GeneCards Identifiers for HNRNPA3 Gene

  • GC02P177786
  • GC02P178077
  • GC02P169948

Summaries for HNRNPA3 Gene

GeneCards Summary for HNRNPA3 Gene

HNRNPA3 (Heterogeneous Nuclear Ribonucleoprotein A3) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPA0.

UniProtKB/Swiss-Prot for HNRNPA3 Gene

  • Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.

Gene Wiki entry for HNRNPA3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA3 Gene

Genomics for HNRNPA3 Gene

Regulatory Elements for HNRNPA3 Gene

Promoters for HNRNPA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HNRNPA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HNRNPA3 Gene

Chromosome:
2
Start:
177,212,314 bp from pter
End:
177,223,959 bp from pter
Size:
11,646 bases
Orientation:
Plus strand

Genomic View for HNRNPA3 Gene

Genes around HNRNPA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA3 Gene

Proteins for HNRNPA3 Gene

  • Protein details for HNRNPA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51991-ROA3_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A3
    Protein Accession:
    P51991
    Secondary Accessions:
    • D3DPF4
    • Q53RW7
    • Q6URK5

    Protein attributes for HNRNPA3 Gene

    Size:
    378 amino acids
    Molecular mass:
    39595 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Alternative splice isoforms for HNRNPA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPA3 Gene

Proteomics data for HNRNPA3 Gene at MOPED

Post-translational modifications for HNRNPA3 Gene

  • Ubiquitination at Lys 4, Lys 36, Lys 57, Lys 73, and Lys 151
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPA3 Gene

No data available for DME Specific Peptides for HNRNPA3 Gene

Domains & Families for HNRNPA3 Gene

Gene Families for HNRNPA3 Gene

Protein Domains for HNRNPA3 Gene

Suggested Antigen Peptide Sequences for HNRNPA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51991

UniProtKB/Swiss-Prot:

ROA3_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPA3: view

Function for HNRNPA3 Gene

Molecular function for HNRNPA3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for HNRNPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding TAS 8101480
GO:0051033 RNA transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with HNRNPA3: view

Phenotypes for HNRNPA3 Gene

GenomeRNAi human phenotypes for HNRNPA3:
genes like me logo Genes that share phenotypes with HNRNPA3: view

Animal Model Products

miRNA for HNRNPA3 Gene

miRTarBase miRNAs that target HNRNPA3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA3 Gene

Localization for HNRNPA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA3 Gene

Nucleus. Note=Component of ribonucleosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPA3 Gene COMPARTMENTS Subcellular localization image for HNRNPA3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HNRNPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0043005 neuron projection IEA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with HNRNPA3: view

Pathways & Interactions for HNRNPA3 Gene

genes like me logo Genes that share pathways with HNRNPA3: view

Pathways by source for HNRNPA3 Gene

Gene Ontology (GO) - Biological Process for HNRNPA3 Gene

None

No data available for SIGNOR curated interactions for HNRNPA3 Gene

Drugs & Compounds for HNRNPA3 Gene

No Compound Related Data Available

Transcripts for HNRNPA3 Gene

Unigene Clusters for HNRNPA3 Gene

Heterogeneous nuclear ribonucleoprotein A3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA3 Gene

No ASD Table

Relevant External Links for HNRNPA3 Gene

GeneLoc Exon Structure for
HNRNPA3
ECgene alternative splicing isoforms for
HNRNPA3

Expression for HNRNPA3 Gene

mRNA expression in normal human tissues for HNRNPA3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPA3 Gene



SOURCE GeneReport for Unigene cluster for HNRNPA3 Gene Hs.516539

genes like me logo Genes that share expression patterns with HNRNPA3: view

Protein tissue co-expression partners for HNRNPA3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPA3 Gene

Orthologs for HNRNPA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 84 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HNRNPA3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm6793 36
  • 99 (a)
OneToMany
Gm8991 36
  • 97 (a)
OneToMany
Gm9242 36
  • 99 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia HNRNPA3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPA3 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPA3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPA3 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17064 35
zebrafish
(Danio rerio)
Actinopterygii hnrnpa3 36
  • 83 (a)
OneToOne
Species with no ortholog for HNRNPA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPA3 Gene

ENSEMBL:
Gene Tree for HNRNPA3 (if available)
TreeFam:
Gene Tree for HNRNPA3 (if available)

Paralogs for HNRNPA3 Gene

Paralogs for HNRNPA3 Gene

(15) SIMAP similar genes for HNRNPA3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HNRNPA3: view

Variants for HNRNPA3 Gene

Sequence variations from dbSNP and Humsavar for HNRNPA3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs60370412 -- 177,210,542(+) TTTTT(-/TTT)GAGGC upstream-variant-2KB
rs61386755 -- 177,210,380(+) CTAAT(-/T)TTTTT upstream-variant-2KB
rs145036507 -- 177,210,521(+) CGGCC(-/TTT)TTTTT upstream-variant-2KB
rs375796186 -- 177,210,461(+) CGTGA(A/T)CCGCC upstream-variant-2KB
rs534304531 -- 177,210,709(+) TTTTT(A/T)AAAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA3 Gene

Variant ID Type Subtype PubMed ID
nsv834465 CNV Loss 17160897

Variation tolerance for HNRNPA3 Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPA3 Gene

HapMap Linkage Disequilibrium report
HNRNPA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA3 Gene

Disorders for HNRNPA3 Gene

Relevant External Links for HNRNPA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPA3

No disorders were found for HNRNPA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPA3 Gene

Publications for HNRNPA3 Gene

  1. Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein. (PMID: 11886857) Ma A.S.W. … Smith R. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. HnRNP A3 genes and pseudogenes in the vertebrate genomes. (PMID: 15776420) Makeyev A.V. … Bayarsaihan D. (J. Exp. Zoolog. Part A Comp. Exp. Biol. 2005) 2 3 23
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for HNRNPA3 Gene

Sources for HNRNPA3 Gene

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