Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HNRNPA3 Gene

Aliases for HNRNPA3 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A3 2 3 5
  • HNRPA3 3 4
  • 2610510D13Rik 3
  • HnRNP A3 4
  • D10S102 3
  • FBRNP 3

External Ids for HNRNPA3 Gene

Previous HGNC Symbols for HNRNPA3 Gene

  • HNRPA3

Previous GeneCards Identifiers for HNRNPA3 Gene

  • GC02P177786
  • GC02P178077
  • GC02P169948

Summaries for HNRNPA3 Gene

GeneCards Summary for HNRNPA3 Gene

HNRNPA3 (Heterogeneous Nuclear Ribonucleoprotein A3) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPA1.

UniProtKB/Swiss-Prot for HNRNPA3 Gene

  • Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.

Gene Wiki entry for HNRNPA3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA3 Gene

Genomics for HNRNPA3 Gene

Regulatory Elements for HNRNPA3 Gene

Enhancers for HNRNPA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G177237 2 FANTOM5 Ensembl ENCODE dbSUPER 14.9 +30.2 30195 9.4 HDGF PKNOX1 FOXA2 ARNT SIN3A ARID4B FEZF1 ZNF2 YY1 SLC30A9 NFE2L2 HNRNPA3 ENSG00000222043 ENSG00000229337 ENSG00000238295 ENSG00000237178 LOC100130691 LOC105373754 DNAJC19P5 MIR3128
GH02G177235 1.2 Ensembl ENCODE dbSUPER 13.6 +23.9 23887 2.1 L3MBTL2 CEBPG FOSL1 ZNF121 SSRP1 RAD51 ZNF316 JUND ATF3 ZSCAN29 ENSG00000229337 HNRNPA3 ENSG00000222043 NFE2L2 LOC100130691 LOC105373754 DNAJC19P5 MIR3128
GH02G177187 1.3 Ensembl ENCODE 12.5 -24.0 -23952 2.0 FOXA2 MLX ARID4B FEZF1 DMAP1 YY1 SLC30A9 PAF1 SP5 ZHX2 ENSG00000229337 HNRNPA3 LOC100130691 LOC105373754 GC02P177196 LOC391465
GH02G177247 1.1 dbSUPER 12.8 +36.1 36140 1.9 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000229337 HNRNPA3 ENSG00000238295 ENSG00000237178 LOC105373754 MIR3128 DNAJC19P5
GH02G177233 0.5 dbSUPER 13.6 +21.7 21660 1.3 PKNOX1 GATA3 FOXA1 ENSG00000229337 HNRNPA3 ENSG00000222043 NFE2L2 ENSG00000236501 DNAJC19P5 MIR3128
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HNRNPA3 on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000126852 586 3001 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21

Genomic Location for HNRNPA3 Gene

177,212,314 bp from pter
177,223,959 bp from pter
11,646 bases
Plus strand

Genomic View for HNRNPA3 Gene

Genes around HNRNPA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA3 Gene

Proteins for HNRNPA3 Gene

  • Protein details for HNRNPA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A3
    Protein Accession:
    Secondary Accessions:
    • D3DPF4
    • Q53RW7
    • Q6URK5

    Protein attributes for HNRNPA3 Gene

    378 amino acids
    Molecular mass:
    39595 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Alternative splice isoforms for HNRNPA3 Gene


neXtProt entry for HNRNPA3 Gene

Post-translational modifications for HNRNPA3 Gene

  • Ubiquitination at posLast=44, isoforms=236, posLast=5757, isoforms=273, and isoforms=2151
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPA3 Gene

Domains & Families for HNRNPA3 Gene

Gene Families for HNRNPA3 Gene

Suggested Antigen Peptide Sequences for HNRNPA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPA3: view

No data available for UniProtKB/Swiss-Prot for HNRNPA3 Gene

Function for HNRNPA3 Gene

Molecular function for HNRNPA3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for HNRNPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,TAS 22658674
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding IPI 22720776
GO:0051033 RNA transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with HNRNPA3: view

Phenotypes for HNRNPA3 Gene

genes like me logo Genes that share phenotypes with HNRNPA3: view

Animal Model Products

CRISPR Products

miRNA for HNRNPA3 Gene

miRTarBase miRNAs that target HNRNPA3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA3 Gene

Localization for HNRNPA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA3 Gene

Nucleus. Note=Component of ribonucleosomes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPA3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HNRNPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA --
GO:0019013 viral nucleocapsid IEA --
genes like me logo Genes that share ontologies with HNRNPA3: view

Pathways & Interactions for HNRNPA3 Gene

genes like me logo Genes that share pathways with HNRNPA3: view

Pathways by source for HNRNPA3 Gene

Gene Ontology (GO) - Biological Process for HNRNPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process TAS --
genes like me logo Genes that share ontologies with HNRNPA3: view

No data available for SIGNOR curated interactions for HNRNPA3 Gene

Drugs & Compounds for HNRNPA3 Gene

No Compound Related Data Available

Transcripts for HNRNPA3 Gene

Unigene Clusters for HNRNPA3 Gene

Heterogeneous nuclear ribonucleoprotein A3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA3 Gene

No ASD Table

Relevant External Links for HNRNPA3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HNRNPA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPA3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPA3 Gene

Protein tissue co-expression partners for HNRNPA3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPA3 Gene:


SOURCE GeneReport for Unigene cluster for HNRNPA3 Gene:


Evidence on tissue expression from TISSUES for HNRNPA3 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Lung(3.6)
  • Kidney(3.2)
  • Intestine(3)
  • Eye(2.5)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with HNRNPA3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPA3 Gene

Orthologs for HNRNPA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPA3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia HNRNPA3 35
  • 100 (a)
(Bos Taurus)
Mammalia -- 35
  • 99 (a)
(Mus musculus)
Mammalia Gm6793 35
  • 99 (a)
Gm9242 35
  • 99 (a)
Gm8991 35
  • 97 (a)
(Monodelphis domestica)
Mammalia HNRNPA3 35
  • 90 (a)
(Pan troglodytes)
Mammalia -- 35
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia HNRNPA3 35
  • 71 (a)
(Gallus gallus)
Aves HNRNPA3 35
  • 89 (a)
(Anolis carolinensis)
Reptilia HNRNPA3 35
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17064 34
(Danio rerio)
Actinopterygii hnrnpa3 35
  • 83 (a)
Species where no ortholog for HNRNPA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPA3 Gene

Gene Tree for HNRNPA3 (if available)
Gene Tree for HNRNPA3 (if available)

Paralogs for HNRNPA3 Gene

Variants for HNRNPA3 Gene

Sequence variations from dbSNP and Humsavar for HNRNPA3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000317932 -- 177,223,994(+) GTGGA(C/T)TCTAT downstream-variant-500B
rs1000328376 -- 177,215,204(+) TTTAA(A/G)CGATT intron-variant, upstream-variant-2KB
rs1000350105 -- 177,213,493(+) ATAAT(A/T)GGCCT intron-variant, upstream-variant-2KB, reference, missense
rs1000515874 -- 177,223,222(+) AATAA(A/G)GTAAC nc-transcript-variant, utr-variant-3-prime
rs1000616694 -- 177,218,433(+) CGTGT(A/T)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA3 Gene

Variant ID Type Subtype PubMed ID
nsv834465 CNV loss 17160897
nsv963751 CNV duplication 23825009

Variation tolerance for HNRNPA3 Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA3 Gene

Disorders for HNRNPA3 Gene

Relevant External Links for HNRNPA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HNRNPA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPA3 Gene

Publications for HNRNPA3 Gene

  1. Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein. (PMID: 11886857) Ma A.S.W. … Smith R. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. HnRNP A3 genes and pseudogenes in the vertebrate genomes. (PMID: 15776420) Makeyev A.V. … Bayarsaihan D. (J. Exp. Zoolog. Part A Comp. Exp. Biol. 2005) 2 3 22 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4 64

Products for HNRNPA3 Gene

Sources for HNRNPA3 Gene

Loading form....