HNRNPA3 Gene
protein-coding GIFtS: 52
GCID: GC02P178077
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heterogeneous nuclear ribonucleoprotein A3
(Previous symbol: HNRPA3)
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Aliases
for HNRNPA3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Heterogeneous Nuclear Ribonucleoprotein A31 2 | | HNRPA31 2 3 5 | | HnRNP A32 3 | | D10S1022 5 | | FBRNP2 5 | | 2610510D13Rik2 |
Export aliases for HNRNPA3 gene to outside databasesPrevious GC identifers: GC02P177786 GC02P169948 |
Summaries
for HNRNPA3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ROA3_HUMAN, P51991Function: Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May beinvolved in pre-mRNA splicing
Gene Wiki entry for HNRNPA3 (HNRPA3)
|
Genomic Views
for HNRNPA3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HNRNPA3 gene promoter:
USF1 Pax-5 USF2 POU6F1 (c2) USF-1:USF-2 AREB6 FOXJ2 (long isoform) USF-1 FOXJ2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for HNRNPA3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPA3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q31.2 Ensembl cytogenetic band: 2q31.2 HGNC cytogenetic band: 2q31.2HNRNPA3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P178077: view genomic region
(about GC identifiers)
Start:
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178,077,291 bp from pter |
End:
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178,088,685 bp from pter |
Size:
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11,395 bases |
Orientation:
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plus strand |
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Proteins
for HNRNPA3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ROA3_HUMAN, P51991 (See
protein sequence)Recommended Name: Heterogeneous nuclear ribonucleoprotein A3 Size: 378 amino acids; 39595 Da
Subunit: Identified in the spliceosome C complex
Subcellular location: Nucleus (By similarity). Note=Component of ribonucleosomes
Caution: An older version of this entry represented the conceptual translation of what was thought to be HNRNPA3 butwhich was in fact a pseudogene (HNRPA3P1/FBRNP) located on chromosome 10
Secondary accessions: D3DPF4 Q53RW7 Q6URK5Alternative splicing: 2 isoforms: P51991-1 P51991-2 Explore the universe of human proteins at neXtProt for HNRNPA3: NX_P51991
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51991
HNRNPA3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_919223.1
ENSEMBL proteins: ENSP00000376309 ENSP00000408487 ENSP00000416365 ENSP00000416340 ENSP00000400688 Reactome Protein details: P51991
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
HNRNPA3 for ontologies About GeneDecksing
HNRNPA3 Antibody Products:
Assay Products for HNRNPA3: |
Protein
Domains /
Families
for HNRNPA3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HNRNPA3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P51991ProtoNet protein and cluster: P51991 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: ROA3_HUMAN, P51991Similarity: Contains 2 RRM (RNA recognition motif) domains |
Function
for HNRNPA3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ROA3_HUMAN, P51991Function: Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May beinvolved in pre-mRNA splicing
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPA3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPA3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPA3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
HNRNPA3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HNRNPA3:
|
Pathways & Interactions
for HNRNPA3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | | | 2 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for HNRNPA3
1 
Kegg Pathway (Kegg details for HNRNPA3):
HNRNPA3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HNRNPA3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/628 Interacting proteins for HNRNPA3 (P519912, 3 ENSP000003763094) via UniProtKB, MINT, STRING, and/or I2D (see all 628)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
HNRNPA3 for ontologies About GeneDecksing
|
Drugs & Compounds
for HNRNPA3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HNRNPA3
Search CenterWatch for drugs/clinical trials and news about HNRNPA3 / ROA3
|
Transcripts
for HNRNPA3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HNRNPA3 gene: NM_194247.2 Unigene Cluster for HNRNPA3: Heterogeneous nuclear ribonucleoprotein A3 Hs.516539 [show with all ESTs]Unigene Representative Sequence: NM_1942476 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000392524(uc002ulb.1) ENST00000411529(uc002ulc.1 uc002uld.2)
ENST00000416446 ENST00000435711(uc002ule.3) ENST00000432457 ENST00000483137
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPA3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPA3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for HNRNPA3 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HNRNPA3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPA3 |
Additional cDNA sequence: AF517524.1 AK293125.1 AK303208.1 AK304687.1 AK316434.1 AL832246.1 AY363225.1 BC032437.1 BC061894.1 BC064494.1 BC069022.1 BC080591.1 BC112027.1 BC113470.1 BX647217.1 24/46 DOTS entries (see all 46): DT.418108 DT.91993224 DT.100677943 DT.91773440 DT.95265959 DT.91773419 DT.40117308 DT.91773450 DT.95355028 DT.95363889 DT.120761338 DT.91773435 DT.95363883 DT.91949765 DT.121021461 DT.121021560 DT.121271394 DT.121324431 DT.91773429 DT.95331957 DT.97860989 DT.100677941 DT.100677944 DT.100790528 24/801 AceView cDNA sequences (see all 801): N81010 BM800173 AA969807 BQ221848 AA496096 CD521462 BF794023 CR603865 CB129292 BM841433 AI026146 AF517524 CK299193 AA026550 H89678 AW105336 Z42906 BQ213415 BU845878 AA774481 BM820353 BM810184 AA829511 CN484973
GeneLoc Exon Structure
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Expression
for HNRNPA3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HNRNPA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGGGGGCA
About this image
See HNRNPA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HNRNPA3
SOURCE GeneReport for Unigene cluster: Hs.516539
SABiosciences Custom PCR Arrays for HNRNPA3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HNRNPA3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HNRNPA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HNRNPA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRNPA3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPA3 |
Orthologs
for HNRNPA3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HNRNPA3 gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for HNRNPA3 (if available)
TreeFam Gene Tree for HNRNPA3 (if available) |
Paralogs
for HNRNPA3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HNRNPA3 gene
- DAZAP12 HNRNPA2B12 HNRNPA1L22 MSI12 HNRNPD2 HNRNPA12 MSI22 HNRNPA02
- HNRNPAB2 HNRPDL2
18 SIMAP similar genes for HNRNPA3 using alignment to 3 protein entries: ROA3_HUMAN (see all proteins):D10S102 HNRNPA2B1 HNRNPA1 HNRPA3 HNRNPA1L2 RBMY1A1
HNRPA1 HNRNPA0 CIRBP HNRNPAB HNRNPD DAZAP1
MSI1 HNRPDL RBM3 RBM38 MSI2 SRSF5
HNRNPA3 for paralogs About GeneDecksing
5/18 Pseudogenes.org Pseudogenes for HNRNPA3 (see all 18)
PGOHUM00000258471 PGOHUM00000258563 PGOHUM00000258626 PGOHUM00000258709 PGOHUM00000258860
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Genomic Variants
for HNRNPA3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HNRNPA3 (178077291 - 178088685 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HNRNPA3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HNRNPA3 |
|
Disorders
/ Diseases
for HNRNPA3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HNRNPA3 for disorders About GeneDecksing
OMIM gene information: 605372
OMIM disorders: --
5  diseases for HNRNPA3: About MalaCardsmultiple endocrine neoplasia sipple syndrome breast cancer myeloma
malaria
1 disease from the University of Copenhagen DISEASES database for HNRNPA3:Sipple syndrome Export disorders for HNRNPA3 gene to outside databases
|
Publications
for HNRNPA3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HNRNPA3 gene, integrated from 9 sources (see all 54):
(articles sorted by number of sources associating them with HNRNPA3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein. (PubMed id 11886857)1, 2, 3, 9 Ma A.S.W....Smith R. (2002)
- HnRNP A3 genes and pseudogenes in the vertebrate genomes. (PubMed id 15776420)1, 3, 9 Makeyev A.V....Bayarsaihan D. (2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
- A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Expression profile and interactions of hnRNP A3 within hnRNP/mRNP complexes in mammals. (PubMed id 22546510)1 Papadopoulou C....Guialis A. (2012)
|
External Searches for HNRNPA3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing HNRNPA3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HNRNPA3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HNRNPA3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HNRNPA3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HNRNPA3 gene:
Search GeneIP for patents involving HNRNPA3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HNRNPA3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HNRNPA3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HNRNPA3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPA3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HNRNPA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRNPA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HNRNPA3 |
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 | | | HNRNPA3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPA3 |
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