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HNRNPA3 Gene

protein-coding   GIFtS: 53
GCID: GC02P178077

Heterogeneous Nuclear Ribonucleoprotein A3


(Previous symbol: HNRPA3)
  See HNRNPA3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein A31 2
HNRPA31 2 3 5
HnRNP A32 3
D10S1022 5
FBRNP2 5
2610510D13Rik2

External Ids:    HGNC: 249411   Entrez Gene: 2209882   Ensembl: ENSG000001701447   OMIM: 6053725   UniProtKB: P519913   

Export aliases for HNRNPA3 gene to outside databases

Previous GC identifers: GC02P177786 GC02P169948


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HNRNPA3 Gene:
HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3) is a protein-coding gene. Diseases associated with HNRNPA3 include sipple syndrome. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is HNRNPA1.

UniProtKB/Swiss-Prot: ROA3_HUMAN, P51991
Function: Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be
involved in pre-mRNA splicing

Gene Wiki entry for HNRNPA3 (HNRPA3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPA3 gene promoter:
         USF1   Pax-5   USF2   POU6F1 (c2)   USF-1:USF-2   AREB6   FOXJ2 (long isoform)   USF-1   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRNPA3 promoter sequence
   Search Chromatin IP Primers for HNRNPA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.2   Ensembl cytogenetic band:  2q31.2   HGNC cytogenetic band: 2q31.2

HNRNPA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPA3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P178077:  view genomic region     (about GC identifiers)

Start:
178,077,291 bp from pter      End:
178,088,686 bp from pter
Size:
11,396 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ROA3_HUMAN, P51991 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein A3  
Size: 378 amino acids; 39595 Da
Subunit: Identified in the spliceosome C complex
Caution: An older version of this entry represented the conceptual translation of what was thought to be HNRNPA3
but which was in fact a pseudogene (HNRPA3P1/FBRNP) located on chromosome 10
Secondary accessions: D3DPF4 Q53RW7 Q6URK5
Alternative splicing: 2 isoforms:  P51991-1   P51991-2   

Explore the universe of human proteins at neXtProt for HNRNPA3: NX_P51991

Explore proteomics data for HNRNPA3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys36, Lys57, Lys73, Lys151
  • Modification sites at PhosphoSitePlus

  • See HNRNPA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_919223.1  
    ENSEMBL proteins: 
     ENSP00000376309   ENSP00000408487   ENSP00000416340   ENSP00000400688  
    Reactome Protein details: P51991

    HNRNPA3 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HNRNPA3 

    HNRNPA3 Antibody Products:

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    Search eBioscience for ELISAs for HNRNPA3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P51991

    ProtoNet protein and cluster: P51991

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: ROA3_HUMAN, P51991
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with HNRNPA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROA3_HUMAN, P51991
    Function: Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be
    involved in pre-mRNA splicing

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS8101480
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with HNRNPA3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HNRNPA3:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HNRNPA3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HNRNPA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HNRNPA3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HNRNPA3

    miRNA
    Products:
        
    miRTarBase miRNAs that target HNRNPA3:
    hsa-mir-1229-3p (MIRT036353), hsa-mir-1224-3p (MIRT036550), hsa-mir-484 (MIRT041738), hsa-mir-155-5p (MIRT020978), hsa-mir-346 (MIRT042699), hsa-mir-1 (MIRT024046), hsa-mir-1260b (MIRT052673), hsa-mir-505-3p (MIRT040992)

    Block miRNA regulation of human, mouse, rat HNRNPA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPA3 (see all 188):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-640 hsa-miR-938 hsa-miR-3622b-3p hsa-miR-376a* hsa-miR-510 hsa-miR-4326
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HNRNPA3
    Predesigned siRNA for gene silencing in human, mouse, rat HNRNPA3

    Gene Editing
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    OriGene clones in human, mouse for HNRNPA3 (see all 7)
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    GenScript Custom all cDNA clones Services for HNRNPA3
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPA3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HNRNPA3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ROA3_HUMAN, P51991: Nucleus (By similarity). Note=Component of ribonucleosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus ----
    GO:0030529ribonucleoprotein complex TAS8101480
    GO:0071013catalytic step 2 spliceosome IDA11991638

    Find genes that share ontologies with HNRNPA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPA3 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome


    Find genes that share SuperPaths with HNRNPA3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for HNRNPA3
        mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA


    1 Kegg Pathway  (Kegg details for HNRNPA3):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPA3
    Interactions:

        Search GeneGlobe Interaction Network for HNRNPA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPA3 (P519912, 3 ENSP000003763094) via UniProtKB, MINT, STRING, and/or I2D (see all 696)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5205809 I2D: score=1 STRING: ENSP00000221494
    NSFP464592, 3MINT-7945693 I2D: score=1 
    PUF60Q9UHX12, 3, ENSP000003220164MINT-7945693 I2D: score=2 STRING: ENSP00000322016
    TOP1P113873, ENSP000003545224I2D: score=3 STRING: ENSP00000354522
    ARHGDIAP525653, ENSP000002693214I2D: score=2 STRING: ENSP00000269321
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with HNRNPA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPA3 (ROA3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HNRNPA3 gene: 
    NM_194247.2  

    Unigene Cluster for HNRNPA3:

    Heterogeneous nuclear ribonucleoprotein A3
    Hs.516539  [show with all ESTs]
    Unigene Representative Sequence: NM_194247
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392524(uc002ulb.1) ENST00000411529(uc002ulc.1 uc002uld.2)
    ENST00000435711(uc002ule.3) ENST00000432457 ENST00000483137
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HNRNPA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPA3 (see all 188):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-640 hsa-miR-938 hsa-miR-3622b-3p hsa-miR-376a* hsa-miR-510 hsa-miR-4326
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HNRNPA3
    Predesigned siRNA for gene silencing in human, mouse, rat HNRNPA3
    Clone
    Products:
         
    OriGene clones in human, mouse for HNRNPA3 (see all 7)
    OriGene ORF clones in mouse, rat for HNRNPA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for HNRNPA3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPA3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HNRNPA3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HNRNPA3
      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPA3
      QuantiFast Probe-based Assays in human, mouse, rat HNRNPA3

    Additional mRNA sequence: 

    AF517524.1 AK293125.1 AK303208.1 AK304687.1 AK316434.1 AL832246.1 AY363225.1 BC032437.1 
    BC061894.1 BC064494.1 BC069022.1 BC080591.1 BC112027.1 BC113470.1 BX647217.1 

    Selected DOTS entries (see all 46):

    DT.418108  DT.91993224  DT.100677943  DT.91773440  DT.95265959  DT.40117308  DT.91773419  DT.91773450 
    DT.95355028  DT.95363889  DT.120761338  DT.95363883  DT.91949765  DT.121021461  DT.121021560  DT.121271394 
    DT.91773429  DT.91773435  DT.95331957  DT.97860989  DT.100677941  DT.100677944  DT.100790528  DT.102843011 

    Selected AceView cDNA sequences (see all 801):

    BM810184 AU130689 AA599110 AA906779 BU508500 CD521462 AA365233 BF791596 
    AI683959 CB117308 AA969807 BM721218 W88678 BE675887 AU135178 AA716224 
    BM782965 CR603865 AA773438 AI216419 BU656954 D63090 BM800173 AV702129 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGGGGGCA
    HNRNPA3 Expression
    About this image


    HNRNPA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
    HNRNPA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516539
        Custom PCR Arrays for HNRNPA3
    Primer
    Products:
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HNRNPA3
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    QuantiFast Probe-based Assays in human, mouse, rat HNRNPA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HNRNPA3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpa35 heterogeneous nuclear ribonucleoprotein A3   --   2 (44.75 cM) 75659261 
    chicken
    (Gallus gallus)
    Aves HNRNPA36
    heterogeneous nuclear ribonucleoprotein A3
    89(a)
    1 ↔ 1
    7(15327805-15341998)
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPA36
    heterogeneous nuclear ribonucleoprotein A3
    86(a)
    1 ↔ 1
    GL343411.1(538076-549401)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.170642 Transcribed sequence with moderate similarity to protein more 82.69(n)    142017809 
    zebrafish
    (Danio rerio)
    Actinopterygii hnrnpa36
    heterogeneous nuclear ribonucleoprotein A3
    83(a)
    1 ↔ 1
    9(1682273-1693148) ENSDARG00000059351


    ENSEMBL Gene Tree for HNRNPA3 (if available)
    TreeFam Gene Tree for HNRNPA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPA3 gene
    HNRNPA12  HNRNPD2  HNRNPDL2  HNRNPA02  HNRNPAB2  HNRNPA1L22  HNRNPA2B12  
    15 SIMAP similar genes for HNRNPA3 using alignment to 2 protein entries:     ROA3_HUMAN (see all proteins):
    D10S102    HNRNPA2B1    HNRNPA1    HNRPA3    HNRNPA1L2    HNRPA1
    CIRBP    HNRNPD    HNRNPAB    HNRNPA0    MSI1    RBM3
    RBM38    HNRNPDL    MSI2

    Find genes that share paralogs with HNRNPA3           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for HNRNPA3 (see all 18)
    PGOHUM00000258471 PGOHUM00000258563 PGOHUM00000258626 PGOHUM00000258709 PGOHUM00000258860


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPA3 (see all 257)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815451231,2
    --178078152(+) GTAGTC/GCTTTC 1 -- int10--------
    rs43833691,2
    C,F,H--178078215(+) AAGTCG/AATAAT 1 -- int112Minor allele frequency- A:0.10NS EA WA NA 1312
    rs1442414911,2
    --178078229(+) CCTTTC/TCTTTT 1 -- int10--------
    rs67183931,2
    C,F--178078274(+) AAAAAC/GTTTGC 1 -- int12Minor allele frequency- G:0.07WA 120
    rs1510383451,2
    C--178078298(+) TTCCTA/GATATA 1 -- int10--------
    rs67466571,2
    C,F,H--178078312(+) TTGCTA/GAAGTA 1 -- int110Minor allele frequency- G:0.07NS EA WA NA 1206
    rs1409159941,2
    --178078322(+) ACTTAC/TATTAC 1 -- int10--------
    rs1871300321,2
    --178078348(+) ATGTGG/TGCGAA 1 -- int10--------
    rs1910155391,2
    --178078534(+) GTAGTG/TTCCTG 1 -- int10--------
    rs1832864131,2
    C--178078540(+) TCCTGA/GAATTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for HNRNPA3 (178077291 - 178088686 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HNRNPA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834465CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPA3
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605372    OMIM disorders: --

    1 disease for HNRNPA3:    
    About MalaCards
    sipple syndrome

    1 disease from the University of Copenhagen DISEASES database for HNRNPA3:
    Sipple syndrome

    Find genes that share disorders with HNRNPA3           About GenesLikeMe


    Export disorders for HNRNPA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPA3 gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with HNRNPA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein. (PubMed id 11886857)1, 2, 3, 9 Ma A.S.W....Smith R. (J. Biol. Chem. 2002)
    2. HnRNP A3 genes and pseudogenes in the vertebrate genomes. (PubMed id 15776420)1, 3, 9 Makeyev A.V....Bayarsaihan D. (J. Exp. Zoolog. Part A Comp. Exp. Biol. 2005)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    6. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    7. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    10. Analysis of hnRNPA1, A2/B1, and A3 genes in patients with amyotrophic lateral sclerosis. (PubMed id 23827524)1 Calini D....Silani V. (Neurobiol. Aging 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 220988 HGNC: 24941 AceView: HNRPA3 Ensembl:ENSG00000170144 euGenes: HUgn220988
    ECgene: HNRNPA3 Kegg: 220988 H-InvDB: HNRNPA3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HNRNPA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPA3 gene:
    Search GeneIP for patents involving HNRNPA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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