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Aliases for HNRNPA3 Gene

Aliases for HNRNPA3 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A3 2 3 5
  • HNRPA3 3 4
  • 2610510D13Rik 3
  • HnRNP A3 4
  • D10S102 3
  • FBRNP 3

External Ids for HNRNPA3 Gene

Previous HGNC Symbols for HNRNPA3 Gene

  • HNRPA3

Previous GeneCards Identifiers for HNRNPA3 Gene

  • GC02P177786
  • GC02P178077
  • GC02P169948

Summaries for HNRNPA3 Gene

GeneCards Summary for HNRNPA3 Gene

HNRNPA3 (Heterogeneous Nuclear Ribonucleoprotein A3) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPA1.

UniProtKB/Swiss-Prot for HNRNPA3 Gene

  • Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.

Gene Wiki entry for HNRNPA3 Gene

Additional gene information for HNRNPA3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA3 Gene

Genomics for HNRNPA3 Gene

GeneHancer (GH) Regulatory Elements for HNRNPA3 Gene

Promoters and enhancers for HNRNPA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I177210 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 584.5 +0.9 919 5.4 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC HNRNPA3 ENSG00000229337 MIR4444-1 DNAJC19P5 NFE2L2 LOC100130691 LOC105373754 LOC105373759
GH02I177164 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 51.1 -43.7 -43662 9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 HNRNPA3 DNAJC19P5 RBM45 NFE2L2 ENSG00000222043 ENSG00000236501 LOC105373760 LOC391465 ENSG00000229337
GH02I177391 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 42.7 +183.1 183102 7.2 MLX DMAP1 YY1 SLC30A9 ZNF143 NFYC MEF2D SSRP1 ZNF610 GLIS1 AGPS HNRNPA3 RBM45 LOC100130691 ENSG00000238295 ENSG00000237178 DNAJC19P5 NFE2L2 GC02P177449 GC02M177355
GH02I177260 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.4 +53.6 53637 10 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 GC02P177265 ENSG00000222043 NFE2L2 HNRNPA3 RBM45 DNAJC19P5 LOC100130691 LOC105373754 ENSG00000271825
GH02I177551 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 19.5 +340.7 340673 2.2 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 ZNF207 PIR48086 PIR37119 TTC30B HNRNPA3 DNAJC19P5 AGPS GC02M177472 GC02M177479 GC02M177517 GC02M177516
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HNRNPA3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HNRNPA3 gene promoter:

Genomic Locations for HNRNPA3 Gene

Genomic Locations for HNRNPA3 Gene
chr2:177,212,314-177,223,959
(GRCh38/hg38)
Size:
11,646 bases
Orientation:
Plus strand
chr2:178,077,291-178,088,686
(GRCh37/hg19)

Genomic View for HNRNPA3 Gene

Genes around HNRNPA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA3 Gene

Proteins for HNRNPA3 Gene

  • Protein details for HNRNPA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51991-ROA3_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A3
    Protein Accession:
    P51991
    Secondary Accessions:
    • D3DPF4
    • Q53RW7
    • Q6URK5

    Protein attributes for HNRNPA3 Gene

    Size:
    378 amino acids
    Molecular mass:
    39595 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Alternative splice isoforms for HNRNPA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPA3 Gene

Post-translational modifications for HNRNPA3 Gene

  • Ubiquitination at posLast=44, posLast=3636, isoforms=257, posLast=7373, and posLast=151151

No data available for DME Specific Peptides for HNRNPA3 Gene

Domains & Families for HNRNPA3 Gene

Gene Families for HNRNPA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HNRNPA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPA3: view

No data available for UniProtKB/Swiss-Prot for HNRNPA3 Gene

Function for HNRNPA3 Gene

Molecular function for HNRNPA3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.

Phenotypes From GWAS Catalog for HNRNPA3 Gene

Gene Ontology (GO) - Molecular Function for HNRNPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,TAS 22658674
GO:0005515 protein binding IPI 22720776
genes like me logo Genes that share ontologies with HNRNPA3: view

Phenotypes for HNRNPA3 Gene

genes like me logo Genes that share phenotypes with HNRNPA3: view

Animal Model Products

CRISPR Products

miRNA for HNRNPA3 Gene

miRTarBase miRNAs that target HNRNPA3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA3 Gene

Localization for HNRNPA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA3 Gene

Nucleus. Note=Component of ribonucleosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPA3 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HNRNPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0019013 viral nucleocapsid IEA --
GO:0030529 intracellular ribonucleoprotein complex TAS 8101480
genes like me logo Genes that share ontologies with HNRNPA3: view

Pathways & Interactions for HNRNPA3 Gene

genes like me logo Genes that share pathways with HNRNPA3: view

Pathways by source for HNRNPA3 Gene

Gene Ontology (GO) - Biological Process for HNRNPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0016070 RNA metabolic process TAS --
genes like me logo Genes that share ontologies with HNRNPA3: view

No data available for SIGNOR curated interactions for HNRNPA3 Gene

Drugs & Compounds for HNRNPA3 Gene

No Compound Related Data Available

Transcripts for HNRNPA3 Gene

Unigene Clusters for HNRNPA3 Gene

Heterogeneous nuclear ribonucleoprotein A3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA3 Gene

No ASD Table

Relevant External Links for HNRNPA3 Gene

GeneLoc Exon Structure for
HNRNPA3
ECgene alternative splicing isoforms for
HNRNPA3

Expression for HNRNPA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPA3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPA3 Gene



Protein tissue co-expression partners for HNRNPA3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPA3 Gene:

HNRNPA3

SOURCE GeneReport for Unigene cluster for HNRNPA3 Gene:

Hs.516539

Evidence on tissue expression from TISSUES for HNRNPA3 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Lung(3.6)
  • Kidney(3.2)
  • Intestine(3)
  • Eye(2.5)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with HNRNPA3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPA3 Gene

Orthologs for HNRNPA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPA3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HNRNPA3 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm6793 34
  • 99 (a)
OneToMany
Gm9242 34
  • 99 (a)
OneToMany
Gm8991 34
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia HNRNPA3 34
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPA3 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPA3 34
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPA3 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17064 33
zebrafish
(Danio rerio)
Actinopterygii hnrnpa3 34
  • 83 (a)
OneToOne
Species where no ortholog for HNRNPA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPA3 Gene

ENSEMBL:
Gene Tree for HNRNPA3 (if available)
TreeFam:
Gene Tree for HNRNPA3 (if available)

Paralogs for HNRNPA3 Gene

Variants for HNRNPA3 Gene

Sequence variations from dbSNP and Humsavar for HNRNPA3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000317932 -- 177,223,994(+) T/C downstream_transcript_variant
rs1000328376 -- 177,215,204(+) G/A intron_variant
rs1000350105 -- 177,213,493(+) T/A intron_variant
rs1000515874 -- 177,223,222(+) G/A 3_prime_UTR_variant, non_coding_transcript_variant
rs1000616694 -- 177,218,433(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA3 Gene

Variant ID Type Subtype PubMed ID
nsv834465 CNV loss 17160897
nsv963751 CNV duplication 23825009

Variation tolerance for HNRNPA3 Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA3 Gene

Disorders for HNRNPA3 Gene

Additional Disease Information for HNRNPA3

No disorders were found for HNRNPA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPA3 Gene

Publications for HNRNPA3 Gene

  1. Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein. (PMID: 11886857) Ma AS … Smith R (The Journal of biological chemistry 2002) 2 3 4 22 58
  2. HnRNP A3 genes and pseudogenes in the vertebrate genomes. (PMID: 15776420) Makeyev AV … Bayarsaihan D (Journal of experimental zoology. Part A, Comparative experimental biology 2005) 2 3 22 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica MS … Moore MJ (RNA (New York, N.Y.) 2002) 3 4 58

Products for HNRNPA3 Gene

Sources for HNRNPA3 Gene

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