Aliases for HNRNPA3 Gene
Aliases for HNRNPA3 Gene
External Ids for HNRNPA3 Gene
- HGNC: 24941
- Entrez Gene: 220988
- Ensembl: ENSG00000170144
- OMIM: 605372
- UniProtKB: P51991
Previous HGNC Symbols for HNRNPA3 Gene
- HNRPA3
Previous GeneCards Identifiers for HNRNPA3 Gene
- GC02P177786
- GC02P178077
- GC02P169948
Summaries for HNRNPA3 Gene
GeneCards Summary for HNRNPA3 Gene
HNRNPA3 (Heterogeneous Nuclear Ribonucleoprotein A3) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPA1.
UniProtKB/Swiss-Prot for HNRNPA3 Gene
-
Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA3 Gene
Genomics for HNRNPA3 Gene
Regulatory Elements for HNRNPA3 Gene
- Transcription factor binding sites by QIAGEN in the HNRNPA3 gene promoter:
Regulatory Element Products
Genomic Location for HNRNPA3 Gene
- Chromosome:
- 2
- Start:
- 177,212,314 bp from pter
- End:
- 177,223,959 bp from pter
- Size:
- 11,646 bases
- Orientation:
- Plus strand
Genomic View for HNRNPA3 Gene
- Cytogenetic band:
-
- 2q31.2 by Ensembl
- 2q31.2 by Entrez Gene
- 2q31.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPA3 Gene
Proteins for HNRNPA3 Gene
-
Protein details for HNRNPA3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P51991-ROA3_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoprotein A3
- Protein Accession:
- P51991
- D3DPF4
- Q53RW7
- Q6URK5
Protein attributes for HNRNPA3 Gene
- Size:
- 378 amino acids
- Molecular mass:
- 39595 Da
- Quaternary structure:
-
- Identified in the spliceosome C complex.
Protein Expression for HNRNPA3 Gene
Post-translational modifications for HNRNPA3 Gene
Other Protein References for HNRNPA3 Gene
Antibody Products
- Novus Biologicals Antibodies for HNRNPA3
- Invitrogen Antibodies for HNRNPA3
- antibodies-online Antibodies for HNRNPA3: See all 29
- GeneTex HNRNPA3 antibody for HNRNPA3
Protein Products
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- Novus Biologicals proteins for HNRNPA3
- antibodies-online Proteins for HNRNPA3: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HNRNPA3
Assay Products
- antibodies-online Kits for HNRNPA3: See all 22
No data available for DME Specific Peptides for HNRNPA3 Gene
Domains & Families for HNRNPA3 Gene
Gene Families for HNRNPA3 Gene
Protein Domains for HNRNPA3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPA3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HNRNPA3 Gene
Function for HNRNPA3 Gene
Molecular function for HNRNPA3 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IDA,TAS | 22658674 |
| GO:0003729 | mRNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 22720776 |
| GO:0051033 | RNA transmembrane transporter activity | IEA | -- |
Phenotypes for HNRNPA3 Gene
- GenomeRNAi human phenotypes for HNRNPA3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPA3 gene
-
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- Search ViGene Biosciences for HNRNPA3
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPA3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPA3
- GenScript: Design CRISPR guide RNA sequences for HNRNPA3
miRNA for HNRNPA3 Gene
- miRTarBase miRNAs that target HNRNPA3
-
- hsa-mir-155-5p (MIRT020978)
- hsa-mir-1-3p (MIRT024046)
- hsa-mir-1229-3p (MIRT036353)
- hsa-mir-1224-3p (MIRT036550)
- hsa-mir-505-3p (MIRT040992)
- hsa-mir-484 (MIRT041738)
- hsa-mir-346 (MIRT042699)
- hsa-mir-1260b (MIRT052673)
- hsa-mir-200b-3p (MIRT054550)
- hsa-mir-494-3p (MIRT054719)
- hsa-mir-218-5p (MIRT299659)
- hsa-mir-636 (MIRT299660)
- hsa-mir-548m (MIRT299661)
- hsa-mir-4768-5p (MIRT351802)
- hsa-mir-6833-3p (MIRT351803)
- hsa-mir-32-3p (MIRT351834)
- hsa-mir-4735-5p (MIRT388752)
- hsa-mir-26a-1-3p (MIRT404095)
- hsa-mir-26a-2-3p (MIRT404096)
- hsa-mir-6731-3p (MIRT404097)
- hsa-mir-513b-5p (MIRT498228)
- hsa-mir-4719 (MIRT498229)
- hsa-mir-7853-5p (MIRT498230)
- hsa-mir-105-5p (MIRT498231)
- hsa-mir-6744-3p (MIRT507004)
- hsa-mir-4757-5p (MIRT507005)
- hsa-mir-6781-3p (MIRT507006)
- hsa-mir-2682-3p (MIRT507007)
- hsa-mir-581 (MIRT507008)
- hsa-mir-5692a (MIRT507009)
- hsa-mir-3689e (MIRT574680)
- hsa-mir-3689b-5p (MIRT574681)
- hsa-mir-3689a-5p (MIRT574682)
- hsa-mir-6763-5p (MIRT574683)
- hsa-mir-3978 (MIRT574684)
- hsa-mir-3150a-3p (MIRT574685)
- hsa-mir-5087 (MIRT574686)
- hsa-mir-6825-5p (MIRT574687)
- hsa-mir-939-5p (MIRT574688)
- hsa-mir-1343-5p (MIRT574689)
- hsa-mir-3175 (MIRT574690)
- hsa-mir-6878-5p (MIRT574691)
- hsa-mir-5093 (MIRT574692)
- hsa-mir-6873-3p (MIRT709170)
- hsa-mir-6845-3p (MIRT709171)
- hsa-mir-3680-3p (MIRT725416)
- hsa-mir-557 (MIRT725417)
- hsa-mir-507 (MIRT725418)
- hsa-mir-450b-5p (MIRT725419)
- hsa-mir-4325 (MIRT725420)
- hsa-mir-527 (MIRT725421)
- hsa-mir-518a-5p (MIRT725422)
- hsa-mir-548aw (MIRT725423)
- hsa-mir-4793-3p (MIRT725424)
- hsa-mir-6826-5p (MIRT725425)
- hsa-mir-22-3p (MIRT725426)
- hsa-mir-129-5p (MIRT725427)
miRNA Products
- Search ViGene Biosciences for HNRNPA3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HNRNPA3
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-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA3 gene
Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HNRNPA3
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA3 Gene
Localization for HNRNPA3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA3 Gene
- Nucleus. Note=Component of ribonucleosomes.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 22720776 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0019013 | viral nucleocapsid | IEA | -- |
Pathways & Interactions for HNRNPA3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.50
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for HNRNPA3 Gene
4 Reactome pathways for HNRNPA3 Gene
1 KEGG pathway for HNRNPA3 Gene
Interacting Proteins for HNRNPA3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | IEA | -- |
| GO:0010467 | gene expression | TAS | -- |
| GO:0016070 | RNA metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for HNRNPA3 Gene
Transcripts for HNRNPA3 Gene
mRNA/cDNA for HNRNPA3 Gene
- (11) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (801) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HNRNPA3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPA3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPA3
- GenScript: Design CRISPR guide RNA sequences for HNRNPA3
miRNA Products
- Search ViGene Biosciences for HNRNPA3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HNRNPA3
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-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA3 gene
Clone Products
-
OriGene ORF clones in human for HNRNPA3
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HNRNPA3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPA3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HNRNPA3 Gene:
HNRNPA3SOURCE GeneReport for Unigene cluster for HNRNPA3 Gene:
Hs.516539Evidence on tissue expression from TISSUES for HNRNPA3 Gene
- Nervous system(4.9)
- Liver(4.7)
- Lung(3.6)
- Kidney(3.2)
- Intestine(3)
- Eye(2.5)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for HNRNPA3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPA3 Gene
Orthologs for HNRNPA3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | HNRNPA3 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Gm6793 35 |
|
OneToMany | |
| Gm9242 35 |
|
OneToMany | |||
| Gm8991 35 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | HNRNPA3 35 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HNRNPA3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HNRNPA3 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HNRNPA3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.17064 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hnrnpa3 35 |
|
OneToOne |
- Species where no ortholog for HNRNPA3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HNRNPA3 Gene
Paralogs for HNRNPA3 Gene
(15) SIMAP similar genes for HNRNPA3 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for HNRNPA3 Gene
- PGOHUM00000290429
- PGOHUM00000291338
- PGOHUM00000291982
- PGOHUM00000292957
- PGOHUM00000294786
- PGOHUM00000294824
- PGOHUM00000295688
- PGOHUM00000296379
- PGOHUM00000298421
- PGOHUM00000298822
- PGOHUM00000299475
- PGOHUM00000299803
- PGOHUM00000299961
- PGOHUM00000300274
- PGOHUM00000300795
- PGOHUM00000301363
- PGOHUM00000302829
- PGOHUM00000305361
- PGOHUM00000289824
Variants for HNRNPA3 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000317932 | -- | 177,223,994(+) | GTGGA(C/T)TCTAT | downstream-variant-500B | |
| rs1000328376 | -- | 177,215,204(+) | TTTAA(A/G)CGATT | intron-variant, upstream-variant-2KB | |
| rs1000350105 | -- | 177,213,493(+) | ATAAT(A/T)GGCCT | intron-variant, upstream-variant-2KB, reference, missense | |
| rs1000515874 | -- | 177,223,222(+) | AATAA(A/G)GTAAC | nc-transcript-variant, utr-variant-3-prime | |
| rs1000616694 | -- | 177,218,433(+) | CGTGT(A/T)AAAGA | intron-variant |
Relevant External Links for HNRNPA3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HNRNPA3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA3 Gene
Disorders for HNRNPA3 Gene
Relevant External Links for HNRNPA3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HNRNPA3
No disorders were found for HNRNPA3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPA3 Gene
Publications for HNRNPA3 Gene
- Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein. (PMID: 11886857) Ma A.S.W. … Smith R. (J. Biol. Chem. 2002) 2 3 4 22 64
- HnRNP A3 genes and pseudogenes in the vertebrate genomes. (PMID: 15776420) Makeyev A.V. … Bayarsaihan D. (J. Exp. Zoolog. Part A Comp. Exp. Biol. 2005) 2 3 22 64
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4 64
Products for HNRNPA3 Gene
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- antibodies-online Antibodies for HNRNPA3: See all 29
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- antibodies-online Proteins for HNRNPA3: See all 3
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- ViGene Biosciences adenoviral particle packaged cDNA for HNRNPA3 gene
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HNRNPA3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
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- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
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- (109) TreeFam
- (110) PathCards
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- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




