Aliases for HNRNPA2B1 Gene
Aliases for HNRNPA2B1 Gene
External Ids for HNRNPA2B1 Gene
- HGNC: 5033
- Entrez Gene: 3181
- Ensembl: ENSG00000122566
- OMIM: 600124
- UniProtKB: P22626
Previous HGNC Symbols for HNRNPA2B1 Gene
- HNRPA2B1
Previous GeneCards Identifiers for HNRNPA2B1 Gene
- GC07M026197
Summaries for HNRNPA2B1 Gene
-
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNRNPA2B1 Gene
HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1) is a Protein Coding gene. Diseases associated with HNRNPA2B1 include Inclusion Body Myopathy With Early-Onset Paget Disease With Or Without Frontotemporal Dementia 2 and Oculopharyngeal Muscular Dystrophy. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPA3.
UniProtKB/Swiss-Prot for HNRNPA2B1 Gene
-
Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear reader of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680).
-
(Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA2B1 Gene
Genomics for HNRNPA2B1 Gene
Regulatory Elements for HNRNPA2B1 Gene
Enhancers for HNRNPA2B1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HNRNPA2B1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HNRNPA2B1 gene promoter:
Genomic Location for HNRNPA2B1 Gene
- Chromosome:
- 7
- Start:
- 26,189,927 bp from pter
- End:
- 26,201,529 bp from pter
- Size:
- 11,603 bases
- Orientation:
- Minus strand
Genomic View for HNRNPA2B1 Gene
Genes around HNRNPA2B1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p15.2 by Ensembl
- 7p15.2 by Entrez Gene
- 7p15.2 by HGNC
HNRNPA2B1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPA2B1 Gene
Proteins for HNRNPA2B1 Gene
-
Protein details for HNRNPA2B1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P22626-ROA2_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Protein Accession:
- P22626
- A0A024RA27
- A0A024RA61
- A8K064
- P22627
- Q9UC98
- Q9UDJ2
Protein attributes for HNRNPA2B1 Gene
- Size:
- 353 amino acids
- Molecular mass:
- 37430 Da
- Quaternary structure:
-
- Identified in the spliceosome C complex (PubMed:11991638). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with IGF2BP1 (PubMed:17289661). Interacts with C9orf72 (PubMed:24549040). Interacts with DGCR8 (PubMed:26321680). Interacts with TARDBP (PubMed:19429692). Interacts with CKAP5 (PubMed:15703215).
Three dimensional structures from OCA and Proteopedia for HNRNPA2B1 Gene
Protein Expression for HNRNPA2B1 Gene
Post-translational modifications for HNRNPA2B1 Gene
- Asymmetric dimethylation at Arg-266 constitutes the major methylation site (By similarity). According to a report, methlytion affects subcellular location and promotes nuclear localization (PubMed:10772824). According to another report, methylation at Arg-266 does not influence nucleocytoplasmic shuttling (By similarity).
- Sumoylated in exosomes, promoting miRNAs-binding.
- Ubiquitination at isoforms=3, isoforms=222, posLast=4646, posLast=5959, isoforms=2168, and isoforms=2173
- Modification sites at PhosphoSitePlus
Other Protein References for HNRNPA2B1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HNRNPA2B1
- Cell Signaling Technology (CST) Antibodies for HNRNPA2B1 (hnRNP A2/B1)
- Novus Biologicals Antibodies for HNRNPA2B1
-
Abcam antibodies for HNRNPA2B1
-
Cloud-Clone Corp. Antibodies for HNRNPA2B1
- Invitrogen Antibodies for HNRNPA2B1
- antibodies-online Antibodies for HNRNPA2B1: See all 98
- GeneTex HNRNPA2B1 antibody for HNRNPA2B1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPA2B1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HNRNPA2B1
- Origene Custom Protein Services for HNRNPA2B1
-
Cloud-Clone Corp. Proteins for HNRNPA2B1
- antibodies-online Proteins for HNRNPA2B1: See all 12
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HNRNPA2B1
-
Abcam proteins for HNRNPA2B1
Assay Products
-
Cloud-Clone Corp Assay Kits for HNRNPA2B1
- antibodies-online Kits for HNRNPA2B1: See all 33
No data available for DME Specific Peptides for HNRNPA2B1 Gene
Domains & Families for HNRNPA2B1 Gene
Gene Families for HNRNPA2B1 Gene
Protein Domains for HNRNPA2B1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPA2B1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P22626UniProtKB/Swiss-Prot:
ROA2_HUMAN :- The low complexity (LC) region is intrinsically disordered. When incubated at high concentration, it is able to polymerize into labile, amyloid-like fibers and form cross-beta polymerization structures, probably driving the formation of hydrogels. In contrast to irreversible, pathogenic amyloids, the fibers polymerized from LC regions disassemble upon dilution. A number of evidences suggest that formation of cross-beta structures by LC regions mediate the formation of RNA granules, liquid-like droplets, and hydrogels.
- Domain:
-
- The low complexity (LC) region is intrinsically disordered. When incubated at high concentration, it is able to polymerize into labile, amyloid-like fibers and form cross-beta polymerization structures, probably driving the formation of hydrogels. In contrast to irreversible, pathogenic amyloids, the fibers polymerized from LC regions disassemble upon dilution. A number of evidences suggest that formation of cross-beta structures by LC regions mediate the formation of RNA granules, liquid-like droplets, and hydrogels.
Function for HNRNPA2B1 Gene
Molecular function for HNRNPA2B1 Gene
- UniProtKB/Swiss-Prot Function:
- Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear reader of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | TAS,IDA | 15659580 |
| GO:0003730 | mRNA 3-UTR binding | IDA | 10567417 |
| GO:0005515 | protein binding | IPI | 17289661 |
Phenotypes for HNRNPA2B1 Gene
- GenomeRNAi human phenotypes for HNRNPA2B1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability ratio
- Decreased viability
- Decreased IL-8 secretion
- Increased HPV18 LCR reporter activity
- Decreased homologous recombination repair frequency
- Multipolar spindles
- Decreased BPV1 E2 protein expression
- Increased SMN2 exon 7 inclusion
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPA2B1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA2B1 gene
- Search ViGene Biosciences for HNRNPA2B1
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPA2B1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPA2B1
- GenScript: Design CRISPR guide RNA sequences for HNRNPA2B1
miRNA for HNRNPA2B1 Gene
- miRTarBase miRNAs that target HNRNPA2B1
-
- hsa-mir-103a-3p (MIRT027027)
- hsa-mir-16-5p (MIRT031508)
- hsa-mir-1296-5p (MIRT036075)
- hsa-mir-877-3p (MIRT037116)
- hsa-mir-615-3p (MIRT040278)
- hsa-mir-191-5p (MIRT045809)
- hsa-mir-27b-3p (MIRT046213)
- hsa-mir-30c-5p (MIRT048009)
- hsa-mir-197-3p (MIRT048098)
- hsa-mir-92a-3p (MIRT049721)
- hsa-let-7f-5p (MIRT051404)
- hsa-mir-1260b (MIRT052680)
- hsa-mir-124-3p (MIRT054395)
- hsa-mir-340-5p (MIRT054396)
- hsa-let-7c-3p (MIRT103305)
- hsa-mir-548c-3p (MIRT362352)
- hsa-mir-4446-5p (MIRT409087)
- hsa-mir-580-3p (MIRT446391)
- hsa-mir-539-5p (MIRT446392)
- hsa-mir-302a-5p (MIRT446393)
- hsa-mir-548o-3p (MIRT446394)
- hsa-mir-1323 (MIRT446395)
- hsa-mir-5582-3p (MIRT446396)
- hsa-mir-552-5p (MIRT536791)
- hsa-mir-7158-3p (MIRT536792)
- hsa-mir-4539 (MIRT536793)
- hsa-mir-1224-3p (MIRT536794)
- hsa-mir-4724-5p (MIRT536795)
- hsa-mir-140-3p (MIRT536796)
- hsa-mir-708-3p (MIRT536797)
- hsa-mir-1273d (MIRT536798)
- hsa-mir-4709-3p (MIRT562197)
- hsa-mir-3185 (MIRT562198)
- hsa-mir-3156-5p (MIRT562199)
- hsa-mir-6838-5p (MIRT562200)
- hsa-mir-424-5p (MIRT562201)
- hsa-mir-195-5p (MIRT562202)
- hsa-mir-497-5p (MIRT562203)
- hsa-mir-15a-5p (MIRT562204)
- hsa-mir-15b-5p (MIRT562205)
- hsa-mir-107 (MIRT562206)
- hsa-mir-4477a (MIRT567293)
- hsa-mir-3529-3p (MIRT567294)
- hsa-mir-944 (MIRT567295)
- hsa-mir-551b-5p (MIRT567296)
- hsa-mir-5006-3p (MIRT657349)
- hsa-mir-4755-5p (MIRT657350)
- hsa-mir-374a-3p (MIRT657351)
- hsa-mir-623 (MIRT657352)
- hsa-mir-361-5p (MIRT657353)
- hsa-mir-570-3p (MIRT657354)
- hsa-mir-6832-3p (MIRT657355)
- hsa-mir-2115-3p (MIRT657356)
- hsa-mir-211-5p (MIRT657357)
- hsa-mir-204-5p (MIRT657358)
miRNA Products
- Search ViGene Biosciences for HNRNPA2B1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HNRNPA2B1
- Browse OriGene Inhibitory RNA Products For HNRNPA2B1
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA2B1 gene
Clone Products
- Sino Biological Human cDNA Clone for HNRNPA2B1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HNRNPA2B1
-
ViGene Biosciences adenoviral particle packaged cDNA for HNRNPA2B1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPA2B1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA2B1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA2B1 Gene
Localization for HNRNPA2B1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA2B1 Gene
- Nucleus, nucleoplasm. Cytoplasmic granule. Secreted, exosome. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Component of ribonucleosomes (PubMed:17289661). Not found in the nucleolus (PubMed:17289661). Found in exosomes follwong sumoylation (PubMed:24356509). {ECO:0000269 PubMed:17289661, ECO:0000269 PubMed:24356509}.
- Isoform A2: Nucleus. Cytoplasm. Note=Predominantly nucleoplasmic, however is also found in the cytoplasm of cells in some tissues (PubMed:17289661). {ECO:0000269 PubMed:17289661}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000781 | chromosome, telomeric region | ISS | -- |
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005634 | nucleus | IDA,IEA | 22720776 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005681 | spliceosomal complex | IDA | 9731529 |
Pathways & Interactions for HNRNPA2B1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.41
|
| 2 | Chromatin Regulation / Acetylation | ||
| 3 | Telomere Extension by Telomerase | ||
| 4 | Gene Expression |
.48
|
|
Pathways by source for HNRNPA2B1 Gene
1 Cell Signaling Technology pathway for HNRNPA2B1 Gene
1 BioSystems pathway for HNRNPA2B1 Gene
4 Reactome pathways for HNRNPA2B1 Gene
1 Qiagen pathway for HNRNPA2B1 Gene
Interacting Proteins for HNRNPA2B1 Gene
Selected Interacting proteins:
ENSP00000346694
P22626-ROA2_HUMAN
for HNRNPA2B1 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006397 | mRNA processing | IDA | 2557628 |
| GO:0006406 | mRNA export from nucleus | IDA | 10567417 |
| GO:0006810 | transport | IEA | -- |
Transcripts for HNRNPA2B1 Gene
mRNA/cDNA for HNRNPA2B1 Gene
- (5) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (1106) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HNRNPA2B1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPA2B1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPA2B1
- GenScript: Design CRISPR guide RNA sequences for HNRNPA2B1
miRNA Products
- Search ViGene Biosciences for HNRNPA2B1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HNRNPA2B1
- Browse OriGene Inhibitory RNA Products For HNRNPA2B1
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA2B1 gene
Clone Products
- Sino Biological Human cDNA Clone for HNRNPA2B1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 14b | ^ | 15a | · | 15b | · | 15c | · | 15d | · | 15e | · | 15f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | |||||||||||||
| SP5: | - | ||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | - | - | |||||||||||
| SP9: | - | ||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: | - | - | |||||||||||
| SP13: | - | - |
Expression for HNRNPA2B1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPA2B1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HNRNPA2B1 Gene:
HNRNPA2B1SOURCE GeneReport for Unigene cluster for HNRNPA2B1 Gene:
Hs.487774Evidence on tissue expression from TISSUES for HNRNPA2B1 Gene
- Nervous system(5)
- Liver(4.6)
- Intestine(4.4)
- Lung(4.4)
- Blood(3.6)
- Muscle(3.2)
- Spleen(3.1)
- Heart(3)
- Kidney(3)
- Lymph node(2.9)
- Skin(2.9)
- Bone(2.8)
- Pancreas(2.8)
- Thyroid gland(2.8)
- Eye(2.6)
- Adrenal gland(2.5)
- Bone marrow(2.3)
- Gall bladder(2.3)
- Stomach(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPA2B1 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- immune
- nervous
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- cranial nerve
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- skull
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Abdomen:
- abdominal wall
- kidney
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- peripheral nerve
- peripheral nervous system
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for HNRNPA2B1
-
OriGene qPCR primer pairs and template standards for HNRNPA2B1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPA2B1 Gene
Orthologs for HNRNPA2B1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | HNRNPA2B1 35 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | HNRNPA2B1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HNRNPA2B1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HNRNPA2B1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hnrnpa2b1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hnrnpa2b1 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HNRNPA2B1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HNRNPA2B1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HNRNPA2B1 35 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | hnrpa2b1-prov 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Hrb87F 35 |
|
ManyToMany | |
| Hrb98DE 35 |
|
ManyToMany | |||
| Rb97D 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | hrp-1 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HRP1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10370 35 |
|
OneToMany |
- Species where no ortholog for HNRNPA2B1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for HNRNPA2B1 Gene
Paralogs for HNRNPA2B1 Gene
(17) SIMAP similar genes for HNRNPA2B1 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for HNRNPA2B1 Gene
Variants for HNRNPA2B1 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs397515326 | Pathogenic, Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2 (IBMPFD2) [MIM:615422] | 26,193,346(-) | CAATG(A/T)TTTTG | nc-transcript-variant, reference, missense | |
| rs886038701 | Likely benign | 26,192,540(-) | GGGGG(G/T)TATGG | nc-transcript-variant, reference, synonymous-codon | |
| rs117082250 | Benign | 26,196,414(+) | CCTCT(A/G)AAGTT | nc-transcript-variant, reference, synonymous-codon | |
| rs34317198 | Benign | 26,196,615(+) | GCCTT(C/T)CTTAC | nc-transcript-variant, reference, synonymous-codon | |
| rs41275982 | Benign | 26,197,618(+) | TTTAC(A/G)TACCA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3612615 | CNV | gain | 21293372 |
| esv3891090 | CNV | gain | 25118596 |
| nsv606459 | CNV | gain | 21841781 |
| nsv606460 | CNV | loss | 21841781 |
| nsv7393 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.27;
6.02% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HNRNPA2B1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA2B1 Gene
Disorders for HNRNPA2B1 Gene
(6) MalaCards diseases for HNRNPA2B1 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2 |
|
|
| oculopharyngeal muscular dystrophy |
|
|
| inclusion body myopathy with paget disease of bone and frontotemporal dementia |
|
|
| lung cancer |
|
|
| spinocerebellar ataxia 31 |
|
|
Search HNRNPA2B1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ROA2_HUMAN- Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2 (IBMPFD2) [MIM:615422]: An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance. {ECO:0000269 PubMed:23455423}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for HNRNPA2B1
No data available for Genatlas for HNRNPA2B1 Gene
Publications for HNRNPA2B1 Gene
- Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1. (PMID: 8029005) Biamonti G. … Riva S. (Nucleic Acids Res. 1994) 2 3 4 64
- HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing events. (PMID: 26321680) Alarcon C.R. … Tavazoie S.F. (Cell 2015) 3 4 64
- C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. (PMID: 24549040) Farg M.A. … Atkin J.D. (Hum. Mol. Genet. 2014) 3 4 64
- Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. (PMID: 23455423) Kim H.J. … Taylor J.P. (Nature 2013) 3 4 64
- Arginine methylation of hnRNP A2 does not directly govern its subcellular localization. (PMID: 24098712) Friend L.R. … Smith R. (PLoS ONE 2013) 3 4 64
Products for HNRNPA2B1 Gene
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Sources for HNRNPA2B1 Gene
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