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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNRNPA2B1 Gene

protein-coding   GIFtS: 57
GCID: GC07M026229

heterogeneous nuclear ribonucleoprotein A2/B1


(Previous symbol: HNRPA2B1)
 Explore 37 diseases affiliated with
HNRNPA2B1 via
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our new
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Biological research products
for HNRNPA2B1    

Aliases
for HNRNPA2B1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heterogeneous Nuclear Ribonucleoprotein A2/B11 2     RNPA22
HNRPA2B11 2 3 5     SNRPB12
HNRNPA22     Heterogeneous Nuclear Ribonucleoproteins A2/B12
HNRNPB12     HnRNP A2 / HnRNP B12
HNRPA22     Nuclear Ribonucleoprotein Particle A2 Protein2
HNRPB12     HnRNP A2/B13

External Ids:    HGNC: 50331   Entrez Gene: 31812   Ensembl: ENSG000001225667   OMIM: 6001245   UniProtKB: P226263   

Export aliases for HNRNPA2B1 gene to outside databases

Previous GC identifer: GC07M026197


Summaries
for HNRNPA2B1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HNRNPA2B1:
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated
with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and
transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the
cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two
repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced
transcript variants which encode different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ROA2_HUMAN, P22626
Function: Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP
and heterogeneous nuclear RNA in the nucleus

Gene Wiki entry for HNRNPA2B1 (HNRPA2B1)


Genomic Views
for HNRNPA2B1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNRNPA2B1 gene promoter:
         STAT1   GATA-3   p53   ARP-1   STAT1alpha   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): HNRNPA2B1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HNRNPA2B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPA2B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15

HNRNPA2B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPA2B1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M026229:  view genomic region     (about GC identifiers)

Start:
 26,229,547 bp from pter      End:
 26,241,149 bp from pter
Size:
 11,603 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 26,280,706-26,291,563     

Proteins
for HNRNPA2B1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ROA2_HUMAN, P22626 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoproteins A2/B1  
Size: 353 amino acids; 37430 Da
Subunit: Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB,
ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3,
NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated
mRNAs. Interacts with IGF2BP1
Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing
untranslated mRNAs. Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found in the
cytoplasm of cells in some tissues. Not found in the nucleolus
1 PDB 3D structure from and Proteopedia for HNRNPA2B1:
1X4B (3D)    
Secondary accessions: A8K064 P22627 Q9UC98 Q9UDJ2
Alternative splicing: 2 isoforms:  P22626-1   P22626-2   

Explore the universe of human proteins at neXtProt for HNRNPA2B1: NX_P22626

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P22626

    • HNRNPA2B1 Protein expression data from MOPED and PaxDb:    About this image 
    HNRNPA2B1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002128.1  NP_112533.1  

    ENSEMBL proteins: 
     ENSP00000346694   ENSP00000354021   ENSP00000349101  
    Reactome Protein details: P22626
    Human Recombinant Protein Products for HNRNPA2B1: 
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    Novus Biologicals HNRNPA2B1 Protein
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    Uscn Proteins for HNRNPA2B1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--

    HNRNPA2B1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HNRNPA2B1

    Protein Domains /
    Families
    for HNRNPA2B1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HNRNPA2B1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P22626

    ProtoNet protein and cluster: P22626

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: ROA2_HUMAN, P22626
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Function
    for HNRNPA2B1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROA2_HUMAN, P22626
    Function: Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP
    and heterogeneous nuclear RNA in the nucleus

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IDA15659580
    GO:0005515protein binding IPI15703215
    GO:0043047single-stranded telomeric DNA binding IDA15659580
    GO:0097157pre-mRNA intronic binding IEA--
         
    HNRNPA2B1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HNRNPA2B1:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HNRNPA2B1 

    miRNA
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    hsa-miR-548j hsa-miR-3678-3p hsa-miR-607 hsa-miR-188-5p hsa-miR-15a hsa-miR-3653 hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmid: HNRNPA2B1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HNRNPA2B1 (see all 5)
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for HNRNPA2B1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA Splicing1.00
    		mRNA Processing0.82
    		mRNA Splicing - Major Pathway1.00
    		mRNA processing0.48
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    2Chromatin Regulation / Acetylation
    		Chromatin Regulation / Acetylation1.00
    3Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HNRNPA2B1
        Chromatin Regulation / Acetylation

    1 BioSystems Pathway for HNRNPA2B1 
        mRNA processing

    5        Reactome Pathways for HNRNPA2B1
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA



    HNRNPA2B1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HNRNPA2B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/951 Interacting proteins for HNRNPA2B1 (P226262, 3 ENSP000003466944) via UniProtKB, MINT, STRING, and/or I2D (see all 951)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370119
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7899812 MINT-7947479 I2D: score=1 STRING: ENSP00000349960
    SNRNP70P086212, 3, ENSP000002214484MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000221448
    DHX9Q082112, 3, ENSP000003565204MINT-7945693 MINT-6542945 I2D: score=1 STRING: ENSP00000356520
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing IDA2557628
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--
    GO:0048025negative regulation of mRNA splicing, via spliceosome IEA--

    HNRNPA2B1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HNRNPA2B1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HNRNPA2B1
    Search CenterWatch for drugs/clinical trials and news about HNRNPA2B1 / ROA2 

    Transcripts
    for HNRNPA2B1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HNRNPA2B1 gene (2 alternative transcripts): 
    NM_002137.3  NM_031243.2  

    Unigene Cluster for HNRNPA2B1:

    Heterogeneous nuclear ribonucleoprotein A2/B1
    Hs.487774  [show with all ESTs]
    Unigene Representative Sequence: NM_031243
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476233 ENST00000354667(uc003sxr.4 uc003sxs.4) ENST00000360787
    ENST00000463181 ENST00000356674 ENST00000490912 ENST00000495810

    miRNA
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    8/119 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRNPA2B1 (see all 119):
    hsa-miR-548j hsa-miR-3678-3p hsa-miR-607 hsa-miR-188-5p hsa-miR-15a hsa-miR-3653 hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmid: HNRNPA2B1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK026373.1 AK129839.1 AK289429.1 BX538099.1 M29064.1 M29065.1 

    24/74 DOTS entries (see all 74):

    DT.100684586  DT.91747637  DT.100684607  DT.92475931  DT.87018294  DT.95102496  DT.87013039  DT.92475968 
    DT.100684595  DT.92475700  DT.121644669  DT.121044189  DT.91748320  DT.91658749  DT.87018306  DT.100684599 
    DT.121043999  DT.100684591  DT.92366371  DT.95357084  DT.100843022  DT.121044018  DT.97857245  DT.100052969 

    24/1106 AceView cDNA sequences (see all 1106):

    AA126497 BQ001067 AA381643 AL597680 BQ771984 AA427526 BC045724 BX440842 
    BU175490 AA889466 CA432534 AI690264 N33217 AI475739 BI093432 BF939566 
    AI272966 H27061 AA381945 N90938 AI086933 CA413154 AA361758 CB529896 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA2B1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a ·
    SP1:                          -                                                           -                                                                     
    SP2:                                                                                      -                                                                     
    SP3:                                                                                      -                                                                     
    SP4:                          -                                   -     -     -     -     -                                                                     
    SP5:                                                                                      -                                         -     -     -     -         

    ExUns: 14b ^ 15a · 15b · 15c · 15d · 15e · 15f
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:        -                                 


    ECgene alternative splicing isoforms for HNRNPA2B1

    Expression
    for HNRNPA2B1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNRNPA2B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGTAATAAG
    HNRNPA2B1 Expression
    About this image

    HNRNPA2B1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HNRNPA2B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNRNPA2B1

    SOURCE GeneReport for Unigene cluster: Hs.487774
        SABiosciences Expression via Pathway-Focused PCR Array including HNRNPA2B1: 
              Telomeres & Telomerase in human mouse rat

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    Orthologs
    for HNRNPA2B1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HNRNPA2B1 gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HNRNPA2B11 heterogeneous nuclear ribonucleoprotein A2/B1 86.92(n)
    98.82(a)    		   420627  NM_001030985.1  NP_001026156.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HNRNPA2B16
    		 --
    		 97(a)
    		 1 ↔ 1
    		 6(31853639-31864391)
    African clawed frog
    (Xenopus laevis)    		 Amphibia hnrpa2b1-prov2 heterogeneous nuclear ribonucleoprotein A2/B1 84.38(n)    BC046692.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1107966
    		 zgc:110796
    		 37(a)
    		 possible ortholog
    		 5(6512450-6515054)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hrb98DE6
    Hrb87F6
    (see all 3)    		 Heterogeneous nuclear ribonucleoprotein at 87F
    (see all 3)    		 38(a)
    35(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 3R(24425556-24431499)
    3R(9482568-9486241)
    worm
    (Caenorhabditis elegans)    		 Secernentea hrp-16
    		 Heterogeneous nuclear ribonucleoprotein A1
    		 37(a)
    		 1 → many
    		 IV(3336921-3338864)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes HRP11 Hrp1p 50.25(n)
    41.21(a)    		   853997   NP_014518.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G078101 RNA recognition motif-containing protein 48.73(n)
    40.37(a)    		   819972  NM_111660.2  NP_566321.1 
    rice
    (Oryza sativa)    		 Liliopsida Os11g06377001 hypothetical protein 45.28(n)
    40.19(a)    		   4350986  NM_001074867.1  NP_001068335.1 


    ENSEMBL Gene Tree for HNRNPA2B1 (if available)
    TreeFam Gene Tree for HNRNPA2B1 (if available) 

    Paralogs
    for HNRNPA2B1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HNRNPA2B1 gene
    HNRNPA32  DAZAP12  HNRNPA1L22  MSI12  HNRNPD2  HNRNPA12  MSI22  HNRNPA02  
    HNRNPAB2  HNRPDL2  
    17 SIMAP similar genes for HNRNPA2B1 using alignment to 2 protein entries:     ROA2_HUMAN (see all proteins):
    D10S102    HNRNPA3    HNRNPA1    HNRNPA1L2    HNRPA3    HNRPA1
    HNRNPA0    HNRNPD    HNRNPAB    MSI2    MSI1    HNRPDL
    DAZAP1    CIRBP    RBM3    RBM38    DAZL

    HNRNPA2B1 for paralogs           About GeneDecksing



    Genomic Variants
    for HNRNPA2B1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/351 NCBI SNPs in HNRNPA2B1 are shown (see all 351)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1501539551,2
    		--26229076(+) TTCAAC/TGTCTT 2 -- ds50010--------
    rs1892036051,2
    		--26229151(+) ATTGAC/TGAACT 2 -- ds50010--------
    rs1912853641,2
    		--26229152(+) TTGACA/GAACTC 2 -- ds50010--------
    rs1454706071,2
    		--26229294(+) TCTTAA/GTTCAG 2 -- ds50010--------
    rs1888167991,2
    		--26229470(+) ATCCAC/TGATTT 2 -- ds50010--------
    rs1488202051,2
    		--26229516(+) AAGCCA/TGAAAC 2 -- ds50010--------
    rs1812431161,2
    		--26229530(+) AGGAGC/TACTCA 2 -- ds50010--------
    rs1869702221,2
    		--26229539(+) CAAACA/GCTGAA 2 -- ds50010--------
    rs1900656461,2
    		--26229560(+) ATAATC/GAACAG 2 -- ut310--------
    rs746467721,2
    		C,F--26229576(+) TATTGG/AGGACA 2 -- ut311Minor allele frequency- A:0.05EA 120

    HapMap Linkage Disequilibrium report for HNRNPA2B1 (26229547 - 26241149 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HNRNPA2B1: --

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    Disorders / Diseases
    for HNRNPA2B1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HNRNPA2B1 for disorders           About GeneDecksing

    OMIM gene information: 600124    OMIM disorders: --

    20/37 diseases for HNRNPA2B1 (see all 37):    About MalaCards
    mixed connective tissue disease    oculopharyngeal muscular dystrophy    japanese encephalitis    connective tissue disease
    squamous cell carcinoma    muscular dystrophy    oral squamous cell carcinoma    esophageal squamous cell carcinoma
    systemic lupus erythematosus    lupus erythematosus    malignant mesothelioma    encephalitis
    autoimmune hepatitis    rheumatoid arthritis    down syndrome    endocarditis
    gastric adenocarcinoma    carcinoma    vaccinia    lung adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for HNRNPA2B1:
    Lung cancer

    10 Novoseek disease relationships for HNRNPA2B1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 63.6 12 12012004 (2), 9815620 (1), 10778995 (1), 9676837 (1) (see all 10)
    premalignant 49.3 1 12660006 (1)
    precancerous lesions 44.2 1 16939492 (1)
    carcinoma squamous cell 37.9 4 10874220 (1), 10665654 (1), 12660006 (1)
    dysplasia 32 2 12660006 (1), 11280744 (1)
    lymphoma t-cell 30.5 1 12579305 (1)
    shock 28.4 7 19284558 (1), 18329347 (1), 16094700 (1), 18310271 (1)
    cancer 27.6 2 11280744 (1)
    nsclc 25.7 3 17067748 (1), 19609729 (1)
    tumors 1.99 2 18401453 (1), 16939492 (1)

    Human Genome Epidemiology (HuGE) Navigator: HNRNPA2B1 (1 document)

    Export disorders for HNRNPA2B1 gene to outside databases

    Publications
    for HNRNPA2B1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNRNPA2B1 gene, integrated from 9 sources (see all 168):
    (articles sorted by number of sources associating them with HNRNPA2B1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1. (PubMed id 8029005)1, 2, 3 Biamonti G.... Riva S. (1994)
    2. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    3. Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)1, 2 Ong S.E.... Mann M. (2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    5. Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1. (PubMed id 7789969)1, 2 Kozu T.... Schaefer K.P. (1995)
    6. Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes. (PubMed id 1699755)1, 2 Bauw G.... Vandekerckhove J. (1990)
    7. Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts. (PubMed id 2557628)1, 2 Burd C.G.... Dreyfuss G. (1989)
    8. Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteins. (PubMed id 3733753)1, 2 Kumar A.... Szer W. (1986)
    9. Differential expression of the early lung cancer detection marker, heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in normal breast and neoplastic breast cancer. (PubMed id 11510693)1, 9 Zhou J....Mulshine J.L. (2001)
    10. Heterogeneous nuclear ribonucleoprotein-A2/B1 modulate collagen prolyl 4-hydroxylase, alpha (I) mRNA stability. (PubMed id 16464861)1, 9 Fahling M....Thiele B.J. (2006)

    External Searches for HNRNPA2B1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HNRNPA2B1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3181 HGNC: 5033 AceView: HNRPA2B1 Ensembl:ENSG00000122566 euGenes: HUgn3181
    ECgene: HNRNPA2B1 H-InvDB: HNRNPA2B1

    Other Databases showing HNRNPA2B1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HNRNPA2B1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNRNPA2B1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HNRNPA2B1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HNRNPA2B1 gene:
    Search GeneIP for patents involving HNRNPA2B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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