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HNRNPA2B1 Gene

protein-coding   GIFtS: 62
GCID: GC07M026229

Heterogeneous Nuclear Ribonucleoprotein A2/B1


(Previous symbol: HNRPA2B1)
  See HNRNPA2B1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein A2/B11 2     RNPA22
HNRPA2B11 2 3 5     SNRPB12
IBMPFD22 5     Heterogeneous Nuclear Ribonucleoproteins A2/B12
HNRNPA22     HnRNP A2 / HnRNP B12
HNRNPB12     Nuclear Ribonucleoprotein Particle A2 Protein2
HNRPA22     HnRNP A2/B13
HNRPB12     

External Ids:    HGNC: 50331   Entrez Gene: 31812   Ensembl: ENSG000001225667   OMIM: 6001245   UniProtKB: P226263   

Export aliases for HNRNPA2B1 gene to outside databases

Previous GC identifer: GC07M026197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPA2B1 Gene:
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins
(hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These
proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other
aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to
shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.
The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been
described to generate two alternatively spliced transcript variants which encode different isoforms. (provided by
RefSeq, Jul 2008)

GeneCards Summary for HNRNPA2B1 Gene:
HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1) is a protein-coding gene. Diseases associated with HNRNPA2B1 include inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2, and inclusion body myopathy with early-onset paget disease and frontotemporal dementia 1. GO annotations related to this gene include single-stranded telomeric DNA binding and RNA binding. An important paralog of this gene is HNRNPA1.

UniProtKB/Swiss-Prot: ROA2_HUMAN, P22626
Function: Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different
hnRNP and heterogeneous nuclear RNA in the nucleus

Gene Wiki entry for HNRNPA2B1 (HNRPA2B1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPA2B1 gene promoter:
         STAT1   GATA-3   p53   ARP-1   STAT1alpha   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): HNRNPA2B1 promoter sequence
   Search Chromatin IP Primers for HNRNPA2B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPA2B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15

HNRNPA2B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPA2B1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M026229:  view genomic region     (about GC identifiers)

Start:
26,229,547 bp from pter      End:
26,241,149 bp from pter
Size:
11,603 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 26,280,706-26,291,563     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ROA2_HUMAN, P22626 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoproteins A2/B1  
Size: 353 amino acids; 37430 Da
Subunit: Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex
containing untranslated mRNAs. Interacts with IGF2BP1
1 PDB 3D structure from and Proteopedia for HNRNPA2B1:
1X4B (3D)    
Secondary accessions: A8K064 P22627 Q9UC98 Q9UDJ2
Alternative splicing: 2 isoforms:  P22626-1   P22626-2   

Explore the universe of human proteins at neXtProt for HNRNPA2B1: NX_P22626

Explore proteomics data for HNRNPA2B1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys22, Lys46, Lys59, Lys120, Lys168, Lys173
  • Modification sites at PhosphoSitePlus

  • See HNRNPA2B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002128.1  NP_112533.1  

    ENSEMBL proteins: 
     ENSP00000346694   ENSP00000354021   ENSP00000349101  
    Reactome Protein details: P22626

    HNRNPA2B1 Human Recombinant Protein Products:

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    Novus Biologicals HNRNPA2B1 Protein
    Novus Biologicals HNRNPA2B1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HNRNPA2B1 

     
    antibodies-online proteins for HNRNPA2B1 (9 products) 

     
    antibodies-online peptides for HNRNPA2B1

    HNRNPA2B1 Antibody Products:

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    Abcam antibodies for HNRNPA2B1 (P22626, O88569)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for HNRNPA2B1
    antibodies-online antibodies for HNRNPA2B1 (63 products) 

    HNRNPA2B1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    antibodies-online kits for HNRNPA2B1 (27 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P22626

    ProtoNet protein and cluster: P22626

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: ROA2_HUMAN, P22626
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with HNRNPA2B1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROA2_HUMAN, P22626
    Function: Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different
    hnRNP and heterogeneous nuclear RNA in the nucleus

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IDA15659580
    GO:0005515protein binding IPI15703215
    GO:0043047single-stranded telomeric DNA binding IDA15659580
         
    Find genes that share ontologies with HNRNPA2B1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for HNRNPA2B1:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a  Increased homologous recombina 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HNRNPA2B1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HNRNPA2B1:
    hsa-mir-92a-3p (MIRT049721), hsa-mir-30c-5p (MIRT048009), hsa-mir-191-5p (MIRT045809), hsa-let-7f-5p (MIRT051404), hsa-mir-27b-3p (MIRT046213), hsa-mir-877-3p (MIRT037116), hsa-mir-615-3p (MIRT040278), hsa-mir-1260b (MIRT052680), hsa-mir-103a-3p (MIRT027027), hsa-mir-16-5p (MIRT031508), hsa-mir-1296-5p (MIRT036075), hsa-mir-197-3p (MIRT048098)

    Block miRNA regulation of human, mouse, rat HNRNPA2B1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPA2B1 (see all 119):
    hsa-miR-548j hsa-miR-3678-3p hsa-miR-607 hsa-miR-188-5p hsa-miR-15a hsa-miR-3653 hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPA2B1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HNRNPA2B1

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    Clone
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    Sino Biological Human cDNA Clone for HNRNPA2B1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPA2B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPA2B1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPA2B1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ROA2_HUMAN, P22626: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing
    untranslated mRNAs. Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found
    in the cytoplasm of cells in some tissues. Not found in the nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005730nucleolus ----
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with HNRNPA2B1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPA2B1 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with HNRNPA2B1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HNRNPA2B1
        Telomere Extension by Telomerase

    1 Cell Signaling Technology (CST) Pathway for HNRNPA2B1
        Chromatin Regulation / Acetylation

    1 BioSystems Pathway for HNRNPA2B1
        mRNA processing


    2 Reactome Pathways for HNRNPA2B1
        mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA


        Pathway & Disease-focused RT2 Profiler PCR Array including HNRNPA2B1: 
              Telomeres & Telomerase in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HNRNPA2B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPA2B1 (P226261, 2, 3 ENSP000003466944) via UniProtKB, MINT, STRING, and/or I2D (see all 1027)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370119
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7899812 MINT-7947479 I2D: score=1 STRING: ENSP00000349960
    SNRNP70P086212, 3, ENSP000002214484MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000221448
    DHX9Q082112, 3, ENSP000003565204MINT-7945693 MINT-6542945 I2D: score=1 STRING: ENSP00000356520
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing IDA2557628
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--
    GO:0048025negative regulation of mRNA splicing, via spliceosome IEA--

    Find genes that share ontologies with HNRNPA2B1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPA2B1 (ROA2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HNRNPA2B1 gene (2 alternative transcripts): 
    NM_002137.3  NM_031243.2  

    Unigene Cluster for HNRNPA2B1:

    Heterogeneous nuclear ribonucleoprotein A2/B1
    Hs.487774  [show with all ESTs]
    Unigene Representative Sequence: NM_031243
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476233 ENST00000354667(uc003sxr.4 uc003sxs.4) ENST00000360787
    ENST00000463181 ENST00000356674 ENST00000490912 ENST00000495810
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HNRNPA2B1 (see all 119):
    hsa-miR-548j hsa-miR-3678-3p hsa-miR-607 hsa-miR-188-5p hsa-miR-15a hsa-miR-3653 hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPA2B1 3' UTR sequence
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPA2B1
      QuantiFast Probe-based Assays in human, mouse, rat HNRNPA2B1

    Additional mRNA sequence: 

    AK026373.1 AK129839.1 AK289429.1 BX538099.1 M29064.1 M29065.1 

    Selected DOTS entries (see all 74):

    DT.100684586  DT.91747637  DT.100684607  DT.92475931  DT.87018294  DT.95102496  DT.87013039  DT.92475968 
    DT.121644669  DT.92475700  DT.100684595  DT.121044189  DT.91748320  DT.91658749  DT.121043999  DT.87018306 
    DT.100684599  DT.100684591  DT.100843022  DT.95357084  DT.92366371  DT.121044018  DT.97857245  DT.100052969 

    Selected AceView cDNA sequences (see all 1106):

    AI624093 BU678210 AA304981 CB122545 BF446246 BE000032 BQ216618 AW168028 
    AA381636 BU615949 AA453200 AI093279 AI570298 AI267864 BM830587 BQ573857 
    AI080704 AI160059 BQ276346 T24609 AI680189 BQ574155 AW104421 BP870729 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA2B1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a ·
    SP1:                          -                                                           -                                                                     
    SP2:                                                                                      -                                                                     
    SP3:                                                                                      -                                                                     
    SP4:                          -                                   -     -     -     -     -                                                                     
    SP5:                                                                                      -                                         -     -     -     -         

    ExUns: 14b ^ 15a · 15b · 15c · 15d · 15e · 15f
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:        -                                 


    ECgene alternative splicing isoforms for HNRNPA2B1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPA2B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTAATAAG
    HNRNPA2B1 Expression
    About this image


    HNRNPA2B1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    HNRNPA2B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPA2B1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.487774
        Pathway & Disease-focused RT2 Profiler PCR Array including HNRNPA2B1: 
              Telomeres & Telomerase in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HNRNPA2B1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpa2b11 , 5 heterogeneous nuclear ribonucleoprotein A2/B11, 5 93.73(n)1
    99.41(a)1
      6 (24.87 cM)5
    533791  NM_016806.31  NP_058086.21 
     514604345 
    chicken
    (Gallus gallus)
    Aves HNRNPA2B11 heterogeneous nuclear ribonucleoprotein A2/B1 86.59(n)
    97.96(a)
      420627  NM_001030985.1  NP_001026156.1 
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPA2B16
    heterogeneous nuclear ribonucleoprotein A2/B1
    97(a)
    1 ↔ 1
    6(31853421-31864391)
    African clawed frog
    (Xenopus laevis)
    Amphibia hnrpa2b1-prov2 heterogeneous nuclear ribonucleoprotein A2/B1 84.38(n)    BC046692.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hrb87F6
    Hrb98DE6
    (see all 3)
    Heterogeneous nuclear ribonucleoprotein at 98DE
    (see all 3)
    44(a)
    44(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3R(9482568-9486241)
    3R(24425556-24431499)
    worm
    (Caenorhabditis elegans)
    Secernentea hrp-16
    Protein HRP-1, isoform a
    47(a)
    1 → many
    IV(3336924-3338867) WBGene00001999
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRP16
    Subunit of cleavage factor I, a five-subunit compl...
    19(a)
    1 → many
    XV(87844-89448) YOL123W


    ENSEMBL Gene Tree for HNRNPA2B1 (if available)
    TreeFam Gene Tree for HNRNPA2B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPA2B1 gene
    HNRNPA12  HNRNPD2  HNRNPDL2  HNRNPA32  HNRNPA02  HNRNPAB2  HNRNPA1L22  
    17 SIMAP similar genes for HNRNPA2B1 using alignment to 2 protein entries:     ROA2_HUMAN (see all proteins):
    D10S102    HNRNPA3    HNRNPA1    HNRNPA1L2    HNRPA3    HNRPA1
    HNRNPA0    HNRNPD    HNRNPAB    MSI2    MSI1    HNRNPDL
    DAZAP1    CIRBP    RBM3    RBM38    DAZL

    Find genes that share paralogs with HNRNPA2B1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPA2B1 (see all 480)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0705914
    Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2 (IBMPFD2)4--see VAR_0705912 D V mis40--------
    rs1501539551,2
    --26194817(+) TTCAAC/TGTCTT 2 -- ds50010--------
    rs1892036051,2
    --26194892(+) ATTGAC/TGAACT 2 -- ds50010--------
    rs1912853641,2
    --26194893(+) TTGACA/GAACTC 2 -- ds50010--------
    rs125335221,2
    H--26194901(+) CTCAGC/GTATTT 2 -- ds50014Minor allele frequency- G:0.00NS EA 420
    rs736832611,2
    C,F--26194903(+) CAGCTG/ATTTCA 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1454706071,2
    --26195035(+) TCTTAA/GTTCAG 2 -- ds50010--------
    rs793401061,2
    F--26195107(+) CACAAT/GAAAAC 2 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1888167991,2
    --26195211(+) ATCCAC/TGATTT 2 -- ds50010--------
    rs1488202051,2
    --26195257(+) AAGCCA/TGAAAC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for HNRNPA2B1 (26229547 - 26241149 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HNRNPA2B1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv7230n71CNV Loss21882294
    dgv7229n71CNV Loss21882294
    nsv887849CNV Gain21882294
    nsv7393OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): HNRNPA2B1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPA2B1
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPA2B1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600124   
    OMIM disorders: 615422  
    UniProtKB/Swiss-Prot: ROA2_HUMAN, P22626
  • Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2
    (IBMPFD2) [MIM:615422]: An autosomal dominant disease characterized by disabling muscle weakness clinically
    resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and
    premature frontotemporal dementia. Clinical features show incomplete penetrance. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 4 diseases for HNRNPA2B1:    
    About MalaCards
    inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2    inclusion body myopathy with early-onset paget disease and frontotemporal dementia 1    oculopharyngeal muscular dystrophy    frontotemporal dementia

    1 disease from the University of Copenhagen DISEASES database for HNRNPA2B1:
    Lung cancer

    Find genes that share disorders with HNRNPA2B1           About GenesLikeMe

    10 Novoseek inferred disease relationships for HNRNPA2B1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 63.6 12 12012004 (2), 9815620 (1), 10778995 (1), 9676837 (1) (see all 10)
    premalignant 49.3 1 12660006 (1)
    precancerous lesions 44.2 1 16939492 (1)
    carcinoma squamous cell 37.9 4 10874220 (1), 10665654 (1), 12660006 (1)
    dysplasia 32 2 12660006 (1), 11280744 (1)
    lymphoma t-cell 30.5 1 12579305 (1)
    shock 28.4 7 19284558 (1), 18329347 (1), 16094700 (1), 18310271 (1)
    cancer 27.6 2 11280744 (1)
    nsclc 25.7 3 17067748 (1), 19609729 (1)
    tumors 1.99 2 18401453 (1), 16939492 (1)

    Genetic Association Database (GAD): HNRNPA2B1
    Human Genome Epidemiology (HuGE) Navigator: HNRNPA2B1 (1 document)

    Export disorders for HNRNPA2B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPA2B1 gene, integrated from 10 sources (see all 198):
    (articles sorted by number of sources associating them with HNRNPA2B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1. (PubMed id 8029005)1, 2, 3 Biamonti G.... Riva S. (Nucleic Acids Res. 1994)
    2. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. (PubMed id 23455423)1, 2 Kim H.J....Taylor J.P. (Nature 2013)
    3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    4. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    5. Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)1, 2 Ong S.E.... Mann M. (Nat. Methods 2004)
    6. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    7. Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1. (PubMed id 7789969)1, 2 Kozu T.... Schaefer K.P. (Genomics 1995)
    8. Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes. (PubMed id 1699755)1, 2 Bauw G.... Vandekerckhove J. (Electrophoresis 1990)
    9. Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts. (PubMed id 2557628)1, 2 Burd C.G.... Dreyfuss G. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    10. Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteins. (PubMed id 3733753)1, 2 Kumar A.... Szer W. (J. Biol. Chem. 1986)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3181 HGNC: 5033 AceView: HNRPA2B1 Ensembl:ENSG00000122566 euGenes: HUgn3181
    ECgene: HNRNPA2B1 H-InvDB: HNRNPA2B1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HNRNPA2B1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPA2B1 gene:
    Search GeneIP for patents involving HNRNPA2B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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