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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNRNPA2B1 Gene

protein-coding   GIFtS: 60
GCID: GC07M026229

Heterogeneous Nuclear Ribonucleoprotein A2/B1


(Previous symbol: HNRPA2B1)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heterogeneous Nuclear Ribonucleoprotein A2/B11 2     RNPA22
HNRPA2B11 2 3 5     SNRPB12
HNRNPA22     Heterogeneous Nuclear Ribonucleoproteins A2/B12
HNRNPB12     HnRNP A2 / HnRNP B12
HNRPA22     Nuclear Ribonucleoprotein Particle A2 Protein2
HNRPB12     HnRNP A2/B13

External Ids:    HGNC: 50331   Entrez Gene: 31812   Ensembl: ENSG000001225667   OMIM: 6001245   UniProtKB: P226263   

Export aliases for HNRNPA2B1 gene to outside databases

Previous GC identifer: GC07M026197


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HNRNPA2B1 Gene:
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins
(hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These
proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other
aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to
shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.
The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been
described to generate two alternatively spliced transcript variants which encode different isoforms. (provided by
RefSeq, Jul 2008)

GeneCards Summary for HNRNPA2B1 Gene: 
HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1) is a protein-coding gene. Diseases associated with HNRNPA2B1 include oculopharyngeal muscular dystrophy, and japanese encephalitis, and among its related super-pathways are mRNA Processing and Generic Transcription Pathway. GO annotations related to this gene include single-stranded telomeric DNA binding and RNA binding. An important paralog of this gene is HNRNPDL.

UniProtKB/Swiss-Prot: ROA2_HUMAN, P22626
Function: Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different
hnRNP and heterogeneous nuclear RNA in the nucleus

Gene Wiki entry for HNRNPA2B1 (HNRPA2B1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNRNPA2B1 gene promoter:
         STAT1   GATA-3   p53   ARP-1   STAT1alpha   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): HNRNPA2B1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HNRNPA2B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPA2B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15

HNRNPA2B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPA2B1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M026229:  view genomic region     (about GC identifiers)

Start:
26,229,547 bp from pter      End:
26,241,149 bp from pter
Size:
11,603 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 26,280,706-26,291,563     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ROA2_HUMAN, P22626 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoproteins A2/B1  
Size: 353 amino acids; 37430 Da
Subunit: Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB,
ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3,
NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated
mRNAs. Interacts with IGF2BP1
Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing
untranslated mRNAs. Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found
in the cytoplasm of cells in some tissues. Not found in the nucleolus
1 PDB 3D structure from and Proteopedia for HNRNPA2B1:
1X4B (3D)    
Secondary accessions: A8K064 P22627 Q9UC98 Q9UDJ2
Alternative splicing: 2 isoforms:  P22626-1   P22626-2   

Explore the universe of human proteins at neXtProt for HNRNPA2B1: NX_P22626

Explore proteomics data for HNRNPA2B1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22626

  • HNRNPA2B1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HNRNPA2B1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002128.1  NP_112533.1  

    ENSEMBL proteins: 
     ENSP00000346694   ENSP00000354021   ENSP00000349101  
    Reactome Protein details: P22626
    Human Recombinant Protein Products for HNRNPA2B1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--

    HNRNPA2B1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P22626

    ProtoNet protein and cluster: P22626

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: ROA2_HUMAN, P22626
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    HNRNPA2B1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROA2_HUMAN, P22626
    Function: Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different
    hnRNP and heterogeneous nuclear RNA in the nucleus

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IDA15659580
    GO:0005515protein binding IPI15703215
    GO:0043047single-stranded telomeric DNA binding IDA15659580
         
    HNRNPA2B1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HNRNPA2B1:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HNRNPA2B1 
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    hsa-miR-548j hsa-miR-3678-3p hsa-miR-607 hsa-miR-188-5p hsa-miR-15a hsa-miR-3653 hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPA2B1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HNRNPA2B1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA processing0.46
    mRNA Splicing - Major Pathway0.82
    2Generic Transcription Pathway
    Gene Expression0.47
    3Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HNRNPA2B1
        Chromatin Regulation / Acetylation

    1 BioSystems Pathway for HNRNPA2B1
        mRNA processing

    5        Reactome Pathways for HNRNPA2B1
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA



    HNRNPA2B1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HNRNPA2B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/993 Interacting proteins for HNRNPA2B1 (P226262, 3 ENSP000003466944) via UniProtKB, MINT, STRING, and/or I2D (see all 993)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370119
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7899812 MINT-7947479 I2D: score=1 STRING: ENSP00000349960
    SNRNP70P086212, 3, ENSP000002214484MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000221448
    DHX9Q082112, 3, ENSP000003565204MINT-7945693 MINT-6542945 I2D: score=1 STRING: ENSP00000356520
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing IDA2557628
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--
    GO:0048025negative regulation of mRNA splicing, via spliceosome IEA--

    HNRNPA2B1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HNRNPA2B1 (ROA2)

    Search CenterWatch for drugs/clinical trials and news about HNRNPA2B1 / ROA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HNRNPA2B1 gene (2 alternative transcripts): 
    NM_002137.3  NM_031243.2  

    Unigene Cluster for HNRNPA2B1:

    Heterogeneous nuclear ribonucleoprotein A2/B1
    Hs.487774  [show with all ESTs]
    Unigene Representative Sequence: NM_031243
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476233 ENST00000354667(uc003sxr.4 uc003sxs.4) ENST00000360787
    ENST00000463181 ENST00000356674 ENST00000490912 ENST00000495810
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/119 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRNPA2B1 (see all 119):
    hsa-miR-548j hsa-miR-3678-3p hsa-miR-607 hsa-miR-188-5p hsa-miR-15a hsa-miR-3653 hsa-miR-371-5p hsa-miR-550a*
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK026373.1 AK129839.1 AK289429.1 BX538099.1 M29064.1 M29065.1 

    24/74 DOTS entries (see all 74):

    DT.100684586  DT.91747637  DT.100684607  DT.92475931  DT.87018294  DT.95102496  DT.87013039  DT.92475968 
    DT.121644669  DT.92475700  DT.100684595  DT.121044189  DT.91748320  DT.91658749  DT.121043999  DT.87018306 
    DT.100684599  DT.100684591  DT.100843022  DT.95357084  DT.92366371  DT.121044018  DT.97857245  DT.100052969 

    24/1106 AceView cDNA sequences (see all 1106):

    AA151101 BF590114 AA380066 BM455855 F11075 AA380242 BI962867 AU280828 
    BG257775 BF110020 BM423851 BG110356 AA315707 T28569 AA381643 AA427526 
    CB161238 BM423351 BF940171 F12801 CD367106 BQ771984 AW016631 BE349459 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA2B1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a ·
    SP1:                          -                                                           -                                                                     
    SP2:                                                                                      -                                                                     
    SP3:                                                                                      -                                                                     
    SP4:                          -                                   -     -     -     -     -                                                                     
    SP5:                                                                                      -                                         -     -     -     -         

    ExUns: 14b ^ 15a · 15b · 15c · 15d · 15e · 15f
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:        -                                 


    ECgene alternative splicing isoforms for HNRNPA2B1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNRNPA2B1 expression in normal human tissues (normalized intensities)      HNRNPA2B1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTAATAAG
    HNRNPA2B1 Expression
    About this image


    HNRNPA2B1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See HNRNPA2B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNRNPA2B1

    SOURCE GeneReport for Unigene cluster: Hs.487774
        SABiosciences Expression via Pathway-Focused PCR Array including HNRNPA2B1: 
              Telomeres & Telomerase in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPA2B1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HNRNPA2B1 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpa2b11 , 5 heterogeneous nuclear ribonucleoprotein A2/B11, 5 93.73(n)1
    99.41(a)1
      6 (24.87 cM)5
    533791  NM_016806.21  NP_058086.21 
     514604345 
    chicken
    (Gallus gallus)
    Aves HNRNPA2B11 heterogeneous nuclear ribonucleoprotein A2/B1 86.92(n)
    98.82(a)
      420627  NM_001030985.1  NP_001026156.1 
    lizard
    (Anolis carolinensis)
    Reptilia HNRNPA2B16
    Uncharacterized protein
    96(a)
    1 ↔ 1
    6(31853421-31864391)
    African clawed frog
    (Xenopus laevis)
    Amphibia hnrpa2b1-prov2 heterogeneous nuclear ribonucleoprotein A2/B1 84.38(n)    BC046692.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hnrnpa36
    heterogeneous nuclear ribonucleoprotein A3
    63(a)
    1 → many
    9(1682273-1693148)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRP11 Hrp1p 50.25(n)
    41.21(a)
      853997   NP_014518.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G078101 RNA recognition motif-containing protein 48.73(n)
    40.37(a)
      819972  NM_111660.2  NP_566321.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g06377001 hypothetical protein 45.28(n)
    40.19(a)
      4350986  NM_001074867.1  NP_001068335.1 


    ENSEMBL Gene Tree for HNRNPA2B1 (if available)
    TreeFam Gene Tree for HNRNPA2B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HNRNPA2B1 gene
    HNRNPDL2  HNRNPA12  HNRNPD2  HNRNPA02  HNRNPA32  HNRNPAB2  DAZAP12  HNRNPA1L22  
    17 SIMAP similar genes for HNRNPA2B1 using alignment to 2 protein entries:     ROA2_HUMAN (see all proteins):
    D10S102    HNRNPA3    HNRNPA1    HNRNPA1L2    HNRPA3    HNRPA1
    HNRNPA0    HNRNPD    HNRNPAB    MSI2    MSI1    HNRPDL
    DAZAP1    CIRBP    RBM3    RBM38    DAZL

    HNRNPA2B1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/479 SNPs in HNRNPA2B1 are shown (see all 479)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501539551,2
    --26194817(+) TTCAAC/TGTCTT 2 -- ds50010--------
    rs1892036051,2
    --26194892(+) ATTGAC/TGAACT 2 -- ds50010--------
    rs1912853641,2
    --26194893(+) TTGACA/GAACTC 2 -- ds50010--------
    rs125335221,2
    H--26194901(+) CTCAGC/GTATTT 2 -- ds50014Minor allele frequency- G:0.00NS EA 420
    rs736832611,2
    C,F--26194903(+) CAGCTG/ATTTCA 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1454706071,2
    --26195035(+) TCTTAA/GTTCAG 2 -- ds50010--------
    rs793401061,2
    F--26195107(+) CACAAT/GAAAAC 2 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1888167991,2
    --26195211(+) ATCCAC/TGATTT 2 -- ds50010--------
    rs1488202051,2
    --26195257(+) AAGCCA/TGAAAC 2 -- ds50010--------
    rs1812431161,2
    --26195271(+) AGGAGC/TACTCA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for HNRNPA2B1 (26229547 - 26241149 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HNRNPA2B1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv7230n71CNV Loss21882294
    dgv7229n71CNV Loss21882294
    nsv887849CNV Gain21882294
    nsv7393OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): HNRNPA2B1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600124    OMIM disorders: --

    20/35 diseases for HNRNPA2B1 (see all 35):    About MalaCards
    oculopharyngeal muscular dystrophy    japanese encephalitis    mixed connective tissue disease    connective tissue disease
    autoimmune hepatitis    endocarditis    malignant mesothelioma    encephalitis
    gastric adenocarcinoma    vaccinia    behcet's disease    muscular dystrophy
    squamous cell carcinoma    lung adenocarcinoma    down syndrome    esophageal squamous cell carcinoma
    oral squamous cell carcinoma    adenocarcinoma    lung cancer    esophagitis

    1 disease from the University of Copenhagen DISEASES database for HNRNPA2B1:
    Lung cancer

    HNRNPA2B1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for HNRNPA2B1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 63.6 12 12012004 (2), 9815620 (1), 10778995 (1), 9676837 (1) (see all 10)
    premalignant 49.3 1 12660006 (1)
    precancerous lesions 44.2 1 16939492 (1)
    carcinoma squamous cell 37.9 4 10874220 (1), 10665654 (1), 12660006 (1)
    dysplasia 32 2 12660006 (1), 11280744 (1)
    lymphoma t-cell 30.5 1 12579305 (1)
    shock 28.4 7 19284558 (1), 18329347 (1), 16094700 (1), 18310271 (1)
    cancer 27.6 2 11280744 (1)
    nsclc 25.7 3 17067748 (1), 19609729 (1)
    tumors 1.99 2 18401453 (1), 16939492 (1)

    Genetic Association Database (GAD): HNRNPA2B1
    Human Genome Epidemiology (HuGE) Navigator: HNRNPA2B1 (1 document)

    Export disorders for HNRNPA2B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNRNPA2B1 gene, integrated from 9 sources (see all 192):
    (articles sorted by number of sources associating them with HNRNPA2B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1. (PubMed id 8029005)1, 2, 3 Biamonti G.... Riva S. (1994)
    2. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    3. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    4. Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)1, 2 Ong S.E.... Mann M. (2004)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    6. Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1. (PubMed id 7789969)1, 2 Kozu T.... Schaefer K.P. (1995)
    7. Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes. (PubMed id 1699755)1, 2 Bauw G.... Vandekerckhove J. (1990)
    8. Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts. (PubMed id 2557628)1, 2 Burd C.G.... Dreyfuss G. (1989)
    9. Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteins. (PubMed id 3733753)1, 2 Kumar A.... Szer W. (1986)
    10. Differential expression of the early lung cancer detection marker, heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in normal breast and neoplastic breast cancer. (PubMed id 11510693)1, 9 Zhou J....Mulshine J.L. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3181 HGNC: 5033 AceView: HNRPA2B1 Ensembl:ENSG00000122566 euGenes: HUgn3181
    ECgene: HNRNPA2B1 H-InvDB: HNRNPA2B1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNRNPA2B1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HNRNPA2B1 gene:
    Search GeneIP for patents involving HNRNPA2B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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