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Aliases for HNRNPA2B1 Gene

Aliases for HNRNPA2B1 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A2/B1 2 3
  • HNRPA2B1 3 4 6
  • IBMPFD2 3 6
  • Heterogeneous Nuclear Ribonucleoproteins A2/B1 3
  • Nuclear Ribonucleoprotein Particle A2 Protein 3
  • HnRNP A2 / HnRNP B1 3
  • HnRNP A2/B1 4
  • HNRNPA2 3
  • HNRNPB1 3
  • HNRPA2 3
  • HNRPB1 3
  • SNRPB1 3
  • RNPA2 3

External Ids for HNRNPA2B1 Gene

Previous HGNC Symbols for HNRNPA2B1 Gene

  • HNRPA2B1

Previous GeneCards Identifiers for HNRNPA2B1 Gene

  • GC07M026197

Summaries for HNRNPA2B1 Gene

Entrez Gene Summary for HNRNPA2B1 Gene

  • This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPA2B1 Gene

HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1) is a Protein Coding gene. Diseases associated with HNRNPA2B1 include inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2 and oculopharyngeal muscular dystrophy. Among its related pathways are Gene Expression and Chromatin Regulation / Acetylation. GO annotations related to this gene include RNA binding and single-stranded telomeric DNA binding. An important paralog of this gene is HNRNPA0.

UniProtKB/Swiss-Prot for HNRNPA2B1 Gene

  • Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus

Gene Wiki entry for HNRNPA2B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA2B1 Gene

Genomics for HNRNPA2B1 Gene

Regulatory Elements for HNRNPA2B1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HNRNPA2B1 Gene

26,189,927 bp from pter
26,201,529 bp from pter
11,603 bases
Minus strand

Genomic View for HNRNPA2B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPA2B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA2B1 Gene

Proteins for HNRNPA2B1 Gene

  • Protein details for HNRNPA2B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heterogeneous nuclear ribonucleoproteins A2/B1
    Protein Accession:
    Secondary Accessions:
    • A8K064
    • P22627
    • Q9UC98
    • Q9UDJ2

    Protein attributes for HNRNPA2B1 Gene

    353 amino acids
    Molecular mass:
    37430 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1. Interacts with C9orf72.

    Three dimensional structures from OCA and Proteopedia for HNRNPA2B1 Gene

    Alternative splice isoforms for HNRNPA2B1 Gene


neXtProt entry for HNRNPA2B1 Gene

Proteomics data for HNRNPA2B1 Gene at MOPED

Post-translational modifications for HNRNPA2B1 Gene

  • Ubiquitination at Lys22, Lys46, Lys59, Lys120, Lys168, and Lys173
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPA2B1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HNRNPA2B1 (hnRNP A2/B1)

No data available for DME Specific Peptides for HNRNPA2B1 Gene

Domains for HNRNPA2B1 Gene

Gene Families for HNRNPA2B1 Gene

  • RBM :RNA binding motif (RRM) containing

Protein Domains for HNRNPA2B1 Gene

Suggested Antigen Peptide Sequences for HNRNPA2B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P22626
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPA2B1: view

Function for HNRNPA2B1 Gene

Molecular function for HNRNPA2B1 Gene

UniProtKB/Swiss-Prot Function:
Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus

Gene Ontology (GO) - Molecular Function for HNRNPA2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IDA 15659580
GO:0005515 protein binding IPI 15703215
GO:0043047 single-stranded telomeric DNA binding IDA 15659580
genes like me logo Genes that share ontologies with HNRNPA2B1: view
genes like me logo Genes that share phenotypes with HNRNPA2B1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPA2B1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPA2B1 Gene

Localization for HNRNPA2B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA2B1 Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found in the cytoplasm of cells in some tissues. Not found in the nucleolus.

Subcellular locations from

Jensen Localization Image for HNRNPA2B1 Gene COMPARTMENTS Subcellular localization image for HNRNPA2B1 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HNRNPA2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HNRNPA2B1: view

Pathways for HNRNPA2B1 Gene

genes like me logo Genes that share pathways with HNRNPA2B1: view

Pathways by source for HNRNPA2B1 Gene

1 Qiagen pathway for HNRNPA2B1 Gene
1 Cell Signaling Technology pathway for HNRNPA2B1 Gene
1 BioSystems pathway for HNRNPA2B1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HNRNPA2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IDA 2557628
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with HNRNPA2B1: view

Transcripts for HNRNPA2B1 Gene

Unigene Clusters for HNRNPA2B1 Gene

Heterogeneous nuclear ribonucleoprotein A2/B1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPA2B1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA2B1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a ·
SP1: - -
SP2: -
SP3: -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - -
SP10: -
SP12: - - - - - -

ExUns: 14b ^ 15a · 15b · 15c · 15d · 15e · 15f
SP5: -
SP8: - -
SP9: -
SP12: - -
SP13: - -

Relevant External Links for HNRNPA2B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HNRNPA2B1 Gene

mRNA expression in normal human tissues for HNRNPA2B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPA2B1 Gene

SOURCE GeneReport for Unigene cluster for HNRNPA2B1 Gene Hs.487774

genes like me logo Genes that share expressions with HNRNPA2B1: view

Expression partners for HNRNPA2B1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPA2B1 Gene

Orthologs for HNRNPA2B1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPA2B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HNRNPA2B1 35
  • 95.69 (n)
  • 99.71 (a)
  • 100 (a)
(Canis familiaris)
Mammalia HNRNPA2B1 35
  • 95.94 (n)
  • 100 (a)
  • 99 (a)
(Mus musculus)
Mammalia Hnrnpa2b1 35
  • 93.73 (n)
  • 99.41 (a)
Hnrnpa2b1 16
Hnrnpa2b1 36
  • 99 (a)
(Pan troglodytes)
Mammalia HNRNPA2B1 35
  • 99.91 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Hnrnpa2b1 35
  • 94.33 (n)
  • 99.72 (a)
(Monodelphis domestica)
Mammalia HNRNPA2B1 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia HNRNPA2B1 36
  • 86 (a)
(Gallus gallus)
Aves HNRNPA2B1 35
  • 86.59 (n)
  • 97.96 (a)
  • 97 (a)
(Anolis carolinensis)
Reptilia HNRNPA2B1 36
  • 97 (a)
African clawed frog
(Xenopus laevis)
Amphibia hnrpa2b1-prov 35
fruit fly
(Drosophila melanogaster)
Insecta Hrb87F 36
  • 44 (a)
Hrb98DE 36
  • 44 (a)
Rb97D 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea hrp-1 36
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10370 36
  • 35 (a)
Species with no ortholog for HNRNPA2B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HNRNPA2B1 Gene

Gene Tree for HNRNPA2B1 (if available)
Gene Tree for HNRNPA2B1 (if available)

Paralogs for HNRNPA2B1 Gene

Paralogs for HNRNPA2B1 Gene

Selected SIMAP similar genes for HNRNPA2B1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HNRNPA2B1: view

Variants for HNRNPA2B1 Gene

Sequence variations from dbSNP and Humsavar for HNRNPA2B1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4273 -- 26,190,669(-) GAAGA(A/G)AAAGT utr-variant-3-prime, intron-variant
rs9806 -- 26,192,176(-) TGAAT(A/G)GATTG utr-variant-3-prime, intron-variant
rs9807 -- 26,191,985(-) AGATT(C/T)TTCTC utr-variant-3-prime, intron-variant
rs992605 -- 26,198,460(-) TCAAA(A/T)ATAGA intron-variant
rs1049851 -- 26,191,904(-) AAGTG(C/G)GTGTG utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA2B1 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887849 CNV Gain 21882294
dgv7229n71 CNV Loss 21882294
dgv7230n71 CNV Loss 21882294

Relevant External Links for HNRNPA2B1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA2B1 Gene

Disorders for HNRNPA2B1 Gene

(1) OMIM Diseases for HNRNPA2B1 Gene (600124)


  • Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2 (IBMPFD2) [MIM:615422]: An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance. {ECO:0000269 PubMed:23455423}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for HNRNPA2B1 Gene

(10) Novoseek inferred disease relationships for HNRNPA2B1 Gene

Disease -log(P) Hits PubMed IDs
cancer lung 63.6 11
premalignant 49.3 1
precancerous lesions 44.2 1
carcinoma squamous cell 37.9 3
dysplasia 32 2

Relevant External Links for HNRNPA2B1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HNRNPA2B1: view

No data available for Genatlas for HNRNPA2B1 Gene

Publications for HNRNPA2B1 Gene

  1. Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1. (PMID: 8029005) Biamonti G. … Riva S. (Nucleic Acids Res. 1994) 2 3 4
  2. Prognostic and diagnostic relevance of hnRNP A2/B1, hnRNP B1 and S100 A2 in non-small cell lung cancer. (PMID: 17067748) Zech V.F. … Hilbe W. (Cancer Detect. Prev. 2006) 3 23
  3. Identification of prion protein binding proteins by combined use of far-Western immunoblotting, two dimensional gel electrophoresis and mass spectrometry. (PMID: 16294306) Strom A. … Stuke A.W. (Proteomics 2006) 3 23
  4. Heterogeneous nuclear ribonucleoprotein-A2/B1 modulate collagen prolyl 4-hydroxylase, alpha (I) mRNA stability. (PMID: 16464861) FAohling M. … Thiele B.J. (J. Biol. Chem. 2006) 3 23
  5. Comparison of osteopontin, beta-catenin and hnRNP B1 expression in lung carcinomas. (PMID: 19609729) Guldur M.E. … Bakir K. (Pathol. Oncol. Res. 2010) 3 23

Products for HNRNPA2B1 Gene

Sources for HNRNPA2B1 Gene

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