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Aliases for HNRNPA2B1 Gene

Aliases for HNRNPA2B1 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A2/B1 2 3 5
  • HNRPA2B1 3 4
  • Heterogeneous Nuclear Ribonucleoproteins A2/B1 3
  • Nuclear Ribonucleoprotein Particle A2 Protein 3
  • HnRNP A2 / HnRNP B1 3
  • HnRNP A2/B1 4
  • HNRNPA2 3
  • HNRNPB1 3
  • IBMPFD2 3
  • HNRPA2 3
  • HNRPB1 3
  • SNRPB1 3
  • RNPA2 3

External Ids for HNRNPA2B1 Gene

Previous HGNC Symbols for HNRNPA2B1 Gene

  • HNRPA2B1

Previous GeneCards Identifiers for HNRNPA2B1 Gene

  • GC07M026197

Summaries for HNRNPA2B1 Gene

Entrez Gene Summary for HNRNPA2B1 Gene

  • This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPA2B1 Gene

HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1) is a Protein Coding gene. Diseases associated with HNRNPA2B1 include Inclusion Body Myopathy With Early-Onset Paget Disease With Or Without Frontotemporal Dementia 2 and Oculopharyngeal Muscular Dystrophy. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPA3.

UniProtKB/Swiss-Prot for HNRNPA2B1 Gene

  • Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear reader of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680).

  • (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport.

Gene Wiki entry for HNRNPA2B1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA2B1 Gene

Genomics for HNRNPA2B1 Gene

Regulatory Elements for HNRNPA2B1 Gene

Enhancers for HNRNPA2B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G027095 3.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 8.9 -936.7 -936667 86.3 MLX ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 HOTAIRM1 HOXA10-AS HOXA2 HOXA-AS2 HOXA9 HOXA11-AS HOXA10 HOXA11 EIF4HP1 SKAP2
GH07G026151 2 FANTOM5 Ensembl ENCODE dbSUPER 13.6 +45.5 45469 9.7 HNRNPUL1 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 SIN3A DMAP1 ZNF2 HNRNPA2B1 SNX10 CBX3 LOC105375304 ENSG00000273237 NFE2L3
GH07G026372 2.1 ENCODE 10.9 -173.5 -173464 5.5 HDGF PKNOX1 ARID4B FEZF1 ZNF2 ZNF302 ZNF143 ZNF548 SP3 REST HOXA10-AS HOXA9 CBX3 HNRNPA2B1 KIAA0087 C7orf71 SNX10 LOC105375304 LOC441204
GH07G026304 2 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -105.0 -104989 4.7 ZFP64 ARID4B ZNF48 YY1 FOS SP5 JUNB MXD4 MIER2 PPARG SNX10 CBX3 HNRNPA2B1 LOC105375304
GH07G026328 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -128.5 -128500 2.3 HDGF CTCF FOXA2 MAX EBF1 RAD21 ZNF664 EED PATZ1 SMC3 SNX10 CBX3 HNRNPA2B1 LOC105375304
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HNRNPA2B1 on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPA2B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000209748 629 7001 AGO1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 GLIS1 NBN

Genomic Location for HNRNPA2B1 Gene

Chromosome:
7
Start:
26,189,927 bp from pter
End:
26,201,529 bp from pter
Size:
11,603 bases
Orientation:
Minus strand

Genomic View for HNRNPA2B1 Gene

Genes around HNRNPA2B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPA2B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPA2B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA2B1 Gene

Proteins for HNRNPA2B1 Gene

  • Protein details for HNRNPA2B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22626-ROA2_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoproteins A2/B1
    Protein Accession:
    P22626
    Secondary Accessions:
    • A0A024RA27
    • A0A024RA61
    • A8K064
    • P22627
    • Q9UC98
    • Q9UDJ2

    Protein attributes for HNRNPA2B1 Gene

    Size:
    353 amino acids
    Molecular mass:
    37430 Da
    Quaternary structure:
    • Identified in the spliceosome C complex (PubMed:11991638). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with IGF2BP1 (PubMed:17289661). Interacts with C9orf72 (PubMed:24549040). Interacts with DGCR8 (PubMed:26321680). Interacts with TARDBP (PubMed:19429692). Interacts with CKAP5 (PubMed:15703215).

    Three dimensional structures from OCA and Proteopedia for HNRNPA2B1 Gene

    Alternative splice isoforms for HNRNPA2B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPA2B1 Gene

Post-translational modifications for HNRNPA2B1 Gene

  • Asymmetric dimethylation at Arg-266 constitutes the major methylation site (By similarity). According to a report, methlytion affects subcellular location and promotes nuclear localization (PubMed:10772824). According to another report, methylation at Arg-266 does not influence nucleocytoplasmic shuttling (By similarity).
  • Sumoylated in exosomes, promoting miRNAs-binding.
  • Ubiquitination at isoforms=3, isoforms=222, posLast=4646, posLast=5959, isoforms=2168, and isoforms=2173
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPA2B1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HNRNPA2B1 (hnRNP A2/B1)

No data available for DME Specific Peptides for HNRNPA2B1 Gene

Domains & Families for HNRNPA2B1 Gene

Gene Families for HNRNPA2B1 Gene

Suggested Antigen Peptide Sequences for HNRNPA2B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22626

UniProtKB/Swiss-Prot:

ROA2_HUMAN :
  • The low complexity (LC) region is intrinsically disordered. When incubated at high concentration, it is able to polymerize into labile, amyloid-like fibers and form cross-beta polymerization structures, probably driving the formation of hydrogels. In contrast to irreversible, pathogenic amyloids, the fibers polymerized from LC regions disassemble upon dilution. A number of evidences suggest that formation of cross-beta structures by LC regions mediate the formation of RNA granules, liquid-like droplets, and hydrogels.
Domain:
  • The low complexity (LC) region is intrinsically disordered. When incubated at high concentration, it is able to polymerize into labile, amyloid-like fibers and form cross-beta polymerization structures, probably driving the formation of hydrogels. In contrast to irreversible, pathogenic amyloids, the fibers polymerized from LC regions disassemble upon dilution. A number of evidences suggest that formation of cross-beta structures by LC regions mediate the formation of RNA granules, liquid-like droplets, and hydrogels.
genes like me logo Genes that share domains with HNRNPA2B1: view

Function for HNRNPA2B1 Gene

Molecular function for HNRNPA2B1 Gene

UniProtKB/Swiss-Prot Function:
Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear reader of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport.

Gene Ontology (GO) - Molecular Function for HNRNPA2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding TAS,IDA 15659580
GO:0003730 mRNA 3-UTR binding IDA 10567417
GO:0005515 protein binding IPI 17289661
genes like me logo Genes that share ontologies with HNRNPA2B1: view
genes like me logo Genes that share phenotypes with HNRNPA2B1: view

Human Phenotype Ontology for HNRNPA2B1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for HNRNPA2B1 Gene

miRTarBase miRNAs that target HNRNPA2B1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA2B1 Gene

Localization for HNRNPA2B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA2B1 Gene

Nucleus, nucleoplasm. Cytoplasmic granule. Secreted, exosome. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Component of ribonucleosomes (PubMed:17289661). Not found in the nucleolus (PubMed:17289661). Found in exosomes follwong sumoylation (PubMed:24356509). {ECO:0000269 PubMed:17289661, ECO:0000269 PubMed:24356509}.
Isoform A2: Nucleus. Cytoplasm. Note=Predominantly nucleoplasmic, however is also found in the cytoplasm of cells in some tissues (PubMed:17289661). {ECO:0000269 PubMed:17289661}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPA2B1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HNRNPA2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region ISS --
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA,IEA 22720776
GO:0005654 nucleoplasm IDA,TAS --
GO:0005681 spliceosomal complex IDA 9731529
genes like me logo Genes that share ontologies with HNRNPA2B1: view

Pathways & Interactions for HNRNPA2B1 Gene

genes like me logo Genes that share pathways with HNRNPA2B1: view

Pathways by source for HNRNPA2B1 Gene

1 Cell Signaling Technology pathway for HNRNPA2B1 Gene
1 BioSystems pathway for HNRNPA2B1 Gene

SIGNOR curated interactions for HNRNPA2B1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for HNRNPA2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IDA 2557628
GO:0006406 mRNA export from nucleus IDA 10567417
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with HNRNPA2B1: view

Drugs & Compounds for HNRNPA2B1 Gene

No Compound Related Data Available

Transcripts for HNRNPA2B1 Gene

Unigene Clusters for HNRNPA2B1 Gene

Heterogeneous nuclear ribonucleoprotein A2/B1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA2B1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a ·
SP1: - -
SP2: -
SP3: -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - -
SP10: -
SP11:
SP12: - - - - - -
SP13:

ExUns: 14b ^ 15a · 15b · 15c · 15d · 15e · 15f
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8: - -
SP9: -
SP10:
SP11:
SP12: - -
SP13: - -

Relevant External Links for HNRNPA2B1 Gene

GeneLoc Exon Structure for
HNRNPA2B1
ECgene alternative splicing isoforms for
HNRNPA2B1

Expression for HNRNPA2B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPA2B1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPA2B1 Gene



Protein tissue co-expression partners for HNRNPA2B1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HNRNPA2B1 Gene:

HNRNPA2B1

SOURCE GeneReport for Unigene cluster for HNRNPA2B1 Gene:

Hs.487774

Evidence on tissue expression from TISSUES for HNRNPA2B1 Gene

  • Nervous system(5)
  • Liver(4.6)
  • Intestine(4.4)
  • Lung(4.4)
  • Blood(3.6)
  • Muscle(3.2)
  • Spleen(3.1)
  • Heart(3)
  • Kidney(3)
  • Lymph node(2.9)
  • Skin(2.9)
  • Bone(2.8)
  • Pancreas(2.8)
  • Thyroid gland(2.8)
  • Eye(2.6)
  • Adrenal gland(2.5)
  • Bone marrow(2.3)
  • Gall bladder(2.3)
  • Stomach(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPA2B1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cranial nerve
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
  • kidney
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • peripheral nerve
  • peripheral nervous system
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with HNRNPA2B1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPA2B1 Gene

Orthologs for HNRNPA2B1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPA2B1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia HNRNPA2B1 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HNRNPA2B1 34 35
  • 99.91 (n)
dog
(Canis familiaris)
Mammalia HNRNPA2B1 34 35
  • 95.94 (n)
cow
(Bos Taurus)
Mammalia HNRNPA2B1 34 35
  • 95.69 (n)
rat
(Rattus norvegicus)
Mammalia Hnrnpa2b1 34
  • 94.33 (n)
mouse
(Mus musculus)
Mammalia Hnrnpa2b1 34 16 35
  • 93.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPA2B1 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRNPA2B1 34 35
  • 86.59 (n)
lizard
(Anolis carolinensis)
Reptilia HNRNPA2B1 35
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hnrpa2b1-prov 34
fruit fly
(Drosophila melanogaster)
Insecta Hrb87F 35
  • 44 (a)
ManyToMany
Hrb98DE 35
  • 44 (a)
ManyToMany
Rb97D 35
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-1 35
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10370 35
  • 35 (a)
OneToMany
Species where no ortholog for HNRNPA2B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HNRNPA2B1 Gene

ENSEMBL:
Gene Tree for HNRNPA2B1 (if available)
TreeFam:
Gene Tree for HNRNPA2B1 (if available)

Paralogs for HNRNPA2B1 Gene

(17) SIMAP similar genes for HNRNPA2B1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for HNRNPA2B1 Gene

genes like me logo Genes that share paralogs with HNRNPA2B1: view

Variants for HNRNPA2B1 Gene

Sequence variations from dbSNP and Humsavar for HNRNPA2B1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs397515326 Pathogenic, Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2 (IBMPFD2) [MIM:615422] 26,193,346(-) CAATG(A/T)TTTTG nc-transcript-variant, reference, missense
rs886038701 Likely benign 26,192,540(-) GGGGG(G/T)TATGG nc-transcript-variant, reference, synonymous-codon
rs117082250 Benign 26,196,414(+) CCTCT(A/G)AAGTT nc-transcript-variant, reference, synonymous-codon
rs34317198 Benign 26,196,615(+) GCCTT(C/T)CTTAC nc-transcript-variant, reference, synonymous-codon
rs41275982 Benign 26,197,618(+) TTTAC(A/G)TACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA2B1 Gene

Variant ID Type Subtype PubMed ID
esv3612615 CNV gain 21293372
esv3891090 CNV gain 25118596
nsv606459 CNV gain 21841781
nsv606460 CNV loss 21841781
nsv7393 OTHER inversion 18451855

Variation tolerance for HNRNPA2B1 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPA2B1 Gene

Human Gene Mutation Database (HGMD)
HNRNPA2B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPA2B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA2B1 Gene

Disorders for HNRNPA2B1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for HNRNPA2B1 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ROA2_HUMAN
  • Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2 (IBMPFD2) [MIM:615422]: An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance. {ECO:0000269 PubMed:23455423}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HNRNPA2B1

Genetic Association Database (GAD)
HNRNPA2B1
Human Genome Epidemiology (HuGE) Navigator
HNRNPA2B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPA2B1
genes like me logo Genes that share disorders with HNRNPA2B1: view

No data available for Genatlas for HNRNPA2B1 Gene

Publications for HNRNPA2B1 Gene

  1. Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1. (PMID: 8029005) Biamonti G. … Riva S. (Nucleic Acids Res. 1994) 2 3 4 64
  2. HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing events. (PMID: 26321680) Alarcon C.R. … Tavazoie S.F. (Cell 2015) 3 4 64
  3. C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. (PMID: 24549040) Farg M.A. … Atkin J.D. (Hum. Mol. Genet. 2014) 3 4 64
  4. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. (PMID: 23455423) Kim H.J. … Taylor J.P. (Nature 2013) 3 4 64
  5. Arginine methylation of hnRNP A2 does not directly govern its subcellular localization. (PMID: 24098712) Friend L.R. … Smith R. (PLoS ONE 2013) 3 4 64

Products for HNRNPA2B1 Gene

Sources for HNRNPA2B1 Gene

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