Aliases for HNRNPA2B1 Gene
External Ids for HNRNPA2B1 Gene
Previous Symbols for HNRNPA2B1 Gene
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNRNPA2B1 Gene
HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1) is a Protein Coding gene. Diseases associated with HNRNPA2B1 include inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2 and oculopharyngeal muscular dystrophy. Among its related pathways are Gene Expression and Chromatin Regulation / Acetylation. GO annotations related to this gene include RNA binding and single-stranded telomeric DNA binding. An important paralog of this gene is HNRNPA0.
UniProtKB/Swiss-Prot for HNRNPA2B1 Gene
Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus