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Aliases for HNRNPA1L2 Gene

Aliases for HNRNPA1L2 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A1-Like 2 2 3
  • HnRNP Core Protein A1-Like 2 4
  • HnRNP A1-Like 2 4
  • HNRNPA1L 4

External Ids for HNRNPA1L2 Gene

Previous GeneCards Identifiers for HNRNPA1L2 Gene

  • GC13P052092
  • GC13P053192
  • GC13P033905

Summaries for HNRNPA1L2 Gene

GeneCards Summary for HNRNPA1L2 Gene

HNRNPA1L2 (Heterogeneous Nuclear Ribonucleoprotein A1-Like 2) is a Protein Coding gene. Among its related pathways are Spliceosome. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is HNRNPA0.

UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

  • Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA1L2 Gene

Genomics for HNRNPA1L2 Gene

Regulatory Elements for HNRNPA1L2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HNRNPA1L2 Gene

Start:
52,617,470 bp from pter
End:
52,643,796 bp from pter
Size:
26,327 bases
Orientation:
Plus strand

Genomic View for HNRNPA1L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPA1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA1L2 Gene

Proteins for HNRNPA1L2 Gene

  • Protein details for HNRNPA1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q32P51-RA1L2_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A1-like 2
    Protein Accession:
    Q32P51
    Secondary Accessions:
    • Q5TBS2

    Protein attributes for HNRNPA1L2 Gene

    Size:
    320 amino acids
    Molecular mass:
    34225 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HNRNPA1L2 Gene

Proteomics data for HNRNPA1L2 Gene at MOPED

Post-translational modifications for HNRNPA1L2 Gene

  • Ubiquitination at Lys15 and Lys52
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPA1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPA1L2 Gene

Domains for HNRNPA1L2 Gene

Gene Families for HNRNPA1L2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for HNRNPA1L2 Gene

Suggested Antigen Peptide Sequences for HNRNPA1L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q32P51

UniProtKB/Swiss-Prot:

RA1L2_HUMAN :
  • Q32P51
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPA1L2: view

Function for HNRNPA1L2 Gene

Molecular function for HNRNPA1L2 Gene

UniProtKB/Swiss-Prot Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.

Gene Ontology (GO) - Molecular Function for HNRNPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with HNRNPA1L2: view

Animal Model Products

CRISPR Products

miRNA for HNRNPA1L2 Gene

miRTarBase miRNAs that target HNRNPA1L2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPA1L2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPA1L2 Gene

Localization for HNRNPA1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPA1L2 Gene COMPARTMENTS Subcellular localization image for HNRNPA1L2 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for HNRNPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HNRNPA1L2: view

Pathways for HNRNPA1L2 Gene

SuperPathways for HNRNPA1L2 Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with HNRNPA1L2: view

Pathways by source for HNRNPA1L2 Gene

1 KEGG pathway for HNRNPA1L2 Gene

Interacting Proteins for HNRNPA1L2 Gene

Selected Interacting proteins: Q32P51-RA1L2_HUMAN for HNRNPA1L2 Gene via I2D

Gene Ontology (GO) - Biological Process for HNRNPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with HNRNPA1L2: view

Transcripts for HNRNPA1L2 Gene

mRNA/cDNA for HNRNPA1L2 Gene

Unigene Clusters for HNRNPA1L2 Gene

Heterogeneous nuclear ribonucleoprotein A1-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPA1L2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HNRNPA1L2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA1L2 Gene

No ASD Table

Relevant External Links for HNRNPA1L2 Gene

GeneLoc Exon Structure for
HNRNPA1L2
ECgene alternative splicing isoforms for
HNRNPA1L2

Expression for HNRNPA1L2 Gene

mRNA expression in normal human tissues for HNRNPA1L2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HNRNPA1L2 Gene

SOURCE GeneReport for Unigene cluster for HNRNPA1L2 Gene Hs.447506

genes like me logo Genes that share expressions with HNRNPA1L2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPA1L2 Gene

Orthologs for HNRNPA1L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPA1L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPA1L2 35
  • 98.23 (n)
  • 95.92 (a)
HNRNPA1L2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HNRNPA1L2 36
  • 85 (a)
OneToOne
LOC100848353 35
  • 92.81 (n)
  • 94.37 (a)
dog
(Canis familiaris)
Mammalia HNRNPA1L2 36
  • 86 (a)
OneToOne
LOC608729 35
  • 88.33 (n)
  • 86.56 (a)
mouse
(Mus musculus)
Mammalia Gm5803 35
  • 90.21 (n)
  • 93.12 (a)
Gm5803 16
Gm7729 36
  • 96 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia HNRNPA1L2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToMany
Species with no ortholog for HNRNPA1L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HNRNPA1L2 Gene

ENSEMBL:
Gene Tree for HNRNPA1L2 (if available)
TreeFam:
Gene Tree for HNRNPA1L2 (if available)

Paralogs for HNRNPA1L2 Gene

Paralogs for HNRNPA1L2 Gene

Selected SIMAP similar genes for HNRNPA1L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HNRNPA1L2: view

Variants for HNRNPA1L2 Gene

Sequence variations from dbSNP and Humsavar for HNRNPA1L2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs186900 -- 52,632,578(-) ATATC(C/T)AACTA intron-variant
rs237106 -- 52,635,297(-) TTTAC(A/G)CACTT intron-variant
rs342768 -- 52,634,747(-) ACTCT(A/G)GGATA intron-variant
rs342769 -- 52,634,612(-) ATTAT(A/G)TTTCC intron-variant
rs342770 -- 52,634,102(-) TCTAA(C/T)GAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA1L2 Gene

Variant ID Type Subtype PubMed ID
dgv1588n71 CNV Loss 21882294
nsv820041 CNV Gain 19587683
nsv900087 CNV Loss 21882294
nsv819201 CNV Gain 19587683

Relevant External Links for HNRNPA1L2 Gene

HapMap Linkage Disequilibrium report
HNRNPA1L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

Disorders for HNRNPA1L2 Gene

No disorders were found for HNRNPA1L2 Gene.

No data available for UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

Publications for HNRNPA1L2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3
  4. Identification of proteins associated with ligand-activated estrogen receptor I+ in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PMID: 21182205) Tarallo R. … Weisz A. (Proteomics 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for HNRNPA1L2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HNRNPA1L2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPA1L2
  • Block miRNA regulation of HNRNPA1L2 using miScript Target Protectors

Sources for HNRNPA1L2 Gene

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