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Aliases for HNRNPA1L2 Gene

Aliases for HNRNPA1L2 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A1-Like 2 2 3 5
  • HnRNP Core Protein A1-Like 2 4
  • HnRNP A1-Like 2 4
  • HNRNPA1L 4

External Ids for HNRNPA1L2 Gene

Previous GeneCards Identifiers for HNRNPA1L2 Gene

  • GC13P052092
  • GC13P053192
  • GC13P033905

Summaries for HNRNPA1L2 Gene

GeneCards Summary for HNRNPA1L2 Gene

HNRNPA1L2 (Heterogeneous Nuclear Ribonucleoprotein A1-Like 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is HNRNPA1.

UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

  • Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.

Additional gene information for HNRNPA1L2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA1L2 Gene

Genomics for HNRNPA1L2 Gene

GeneHancer (GH) Regulatory Elements for HNRNPA1L2 Gene

Promoters and enhancers for HNRNPA1L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I052616 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 550.8 +0.1 59 2.1 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 HNRNPA1L2 TPTE2P2 UTP14C ALG11 MRPS31P4 ENSG00000273784 ENSG00000273723
GH13I052642 Promoter 0.5 EPDnew 550.3 +24.9 24942 0.1 HNRNPA1L2 ENSG00000273723 ENSG00000273784
GH13I052640 Promoter 0.5 EPDnew 550.3 +23.3 23316 0.1 HNRNPA1L2 TPTE2P2 MIR759 ENSG00000273723 ENSG00000273784
GH13I052193 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -422.8 -422810 2.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MRPS31P5 ALG11 RPS4XP16 UTP14C SUGT1 CKAP2 INTS6 SERPINE3 INTS6-AS1 TPTE2P2
GH13I052404 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 4 -212.0 -211970 2.6 ZSCAN5A KLF1 FOXA2 SIN3A ZNF76 YY1 ZNF335 ZFHX2 GLIS2 POLR2A THSD1 TPTE2P2 HNRNPA1L2 RNY4P24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HNRNPA1L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HNRNPA1L2 gene promoter:

Genomic Locations for HNRNPA1L2 Gene

Genomic Locations for HNRNPA1L2 Gene
26,327 bases
Plus strand

Genomic View for HNRNPA1L2 Gene

Genes around HNRNPA1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPA1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPA1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA1L2 Gene

Proteins for HNRNPA1L2 Gene

  • Protein details for HNRNPA1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A1-like 2
    Protein Accession:
    Secondary Accessions:
    • Q5TBS2

    Protein attributes for HNRNPA1L2 Gene

    320 amino acids
    Molecular mass:
    34225 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HNRNPA1L2 Gene

Post-translational modifications for HNRNPA1L2 Gene

No Post-translational modifications

Other Protein References for HNRNPA1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPA1L2 Gene

Domains & Families for HNRNPA1L2 Gene

Gene Families for HNRNPA1L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HNRNPA1L2 Gene

Suggested Antigen Peptide Sequences for HNRNPA1L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HNRNPA1L2: view

No data available for UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

Function for HNRNPA1L2 Gene

Molecular function for HNRNPA1L2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.

Gene Ontology (GO) - Molecular Function for HNRNPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with HNRNPA1L2: view

Phenotypes for HNRNPA1L2 Gene

GenomeRNAi human phenotypes for HNRNPA1L2:
genes like me logo Genes that share phenotypes with HNRNPA1L2: view

Animal Model Products

miRNA for HNRNPA1L2 Gene

miRTarBase miRNAs that target HNRNPA1L2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA1L2 Gene

Localization for HNRNPA1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNRNPA1L2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for HNRNPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA --
GO:0019013 viral nucleocapsid IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with HNRNPA1L2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HNRNPA1L2 Gene

Pathways & Interactions for HNRNPA1L2 Gene

SuperPathways for HNRNPA1L2 Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with HNRNPA1L2: view

Pathways by source for HNRNPA1L2 Gene

1 KEGG pathway for HNRNPA1L2 Gene

Interacting Proteins for HNRNPA1L2 Gene

Selected Interacting proteins: Q32P51-RA1L2_HUMAN for HNRNPA1L2 Gene via IID

Gene Ontology (GO) - Biological Process for HNRNPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006810 transport IEA --
GO:0008380 RNA splicing IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with HNRNPA1L2: view

No data available for SIGNOR curated interactions for HNRNPA1L2 Gene

Drugs & Compounds for HNRNPA1L2 Gene

No Compound Related Data Available

Transcripts for HNRNPA1L2 Gene

mRNA/cDNA for HNRNPA1L2 Gene

Unigene Clusters for HNRNPA1L2 Gene

Heterogeneous nuclear ribonucleoprotein A1-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA1L2 Gene

No ASD Table

Relevant External Links for HNRNPA1L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HNRNPA1L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNRNPA1L2 Gene

Protein differential expression in normal tissues from HIPED for HNRNPA1L2 Gene

This gene is overexpressed in Cervix (11.9), Pancreas (10.1), Peripheral blood mononuclear cells (8.2), Nasal epithelium (7.7), and Blymphocyte (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HNRNPA1L2 Gene

Protein tissue co-expression partners for HNRNPA1L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HNRNPA1L2 Gene:


SOURCE GeneReport for Unigene cluster for HNRNPA1L2 Gene:


Evidence on tissue expression from TISSUES for HNRNPA1L2 Gene

  • Nervous system(4.3)
  • Skin(4)
genes like me logo Genes that share expression patterns with HNRNPA1L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPA1L2 Gene

Orthologs for HNRNPA1L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPA1L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HNRNPA1L2 33 34
  • 98.23 (n)
(Mus musculus)
Mammalia Gm7729 34
  • 96 (a)
Gm5803 33
  • 90.21 (n)
Hnrnpa1l2-ps2 16
(Bos Taurus)
Mammalia LOC100848353 33
  • 92.81 (n)
  • 85 (a)
(Canis familiaris)
Mammalia LOC608729 33
  • 88.33 (n)
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
(Monodelphis domestica)
Mammalia HNRNPA1L2 34
  • 81 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 77 (a)
Species where no ortholog for HNRNPA1L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HNRNPA1L2 Gene

Gene Tree for HNRNPA1L2 (if available)
Gene Tree for HNRNPA1L2 (if available)

Paralogs for HNRNPA1L2 Gene

Paralogs for HNRNPA1L2 Gene

(13) SIMAP similar genes for HNRNPA1L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HNRNPA1L2: view

Variants for HNRNPA1L2 Gene

Sequence variations from dbSNP and Humsavar for HNRNPA1L2 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000165340 -- 52,630,925(+) T/A intron_variant
rs1000218296 -- 52,630,563(+) G/T intron_variant
rs1000275863 -- 52,616,274(+) A/G upstream_transcript_variant
rs1000426176 -- 52,636,868(+) A/G intron_variant
rs1000626250 -- 52,616,008(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA1L2 Gene

Variant ID Type Subtype PubMed ID
dgv1653n100 CNV gain 25217958
esv3632103 CNV loss 21293372
esv3892344 CNV loss 25118596
esv3892345 CNV gain 25118596
nsv1044949 CNV gain 25217958
nsv819201 CNV gain 19587683
nsv820041 CNV gain 19587683
nsv976119 CNV duplication 23825009

Variation tolerance for HNRNPA1L2 Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.46; 82.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNRNPA1L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

Disorders for HNRNPA1L2 Gene

Additional Disease Information for HNRNPA1L2

No disorders were found for HNRNPA1L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPA1L2 Gene

Publications for HNRNPA1L2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for HNRNPA1L2 Gene

Sources for HNRNPA1L2 Gene

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