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Aliases for HNRNPA1L2 Gene

Aliases for HNRNPA1L2 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A1-Like 2 2 3 5
  • HnRNP Core Protein A1-Like 2 4
  • HnRNP A1-Like 2 4
  • HNRNPA1L 4

External Ids for HNRNPA1L2 Gene

Previous GeneCards Identifiers for HNRNPA1L2 Gene

  • GC13P052092
  • GC13P053192
  • GC13P033905

Summaries for HNRNPA1L2 Gene

GeneCards Summary for HNRNPA1L2 Gene

HNRNPA1L2 (Heterogeneous Nuclear Ribonucleoprotein A1-Like 2) is a Protein Coding gene. Diseases associated with HNRNPA1L2 include dementia, frontotemporal and amyotrophic lateral sclerosis 1. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is HNRNPA0.

UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

  • Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA1L2 Gene

Genomics for HNRNPA1L2 Gene

Regulatory Elements for HNRNPA1L2 Gene

Promoters for HNRNPA1L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HNRNPA1L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HNRNPA1L2 Gene

Chromosome:
13
Start:
52,617,470 bp from pter
End:
52,643,796 bp from pter
Size:
26,327 bases
Orientation:
Plus strand

Genomic View for HNRNPA1L2 Gene

Genes around HNRNPA1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPA1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPA1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA1L2 Gene

Proteins for HNRNPA1L2 Gene

  • Protein details for HNRNPA1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q32P51-RA1L2_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A1-like 2
    Protein Accession:
    Q32P51
    Secondary Accessions:
    • Q5TBS2

    Protein attributes for HNRNPA1L2 Gene

    Size:
    320 amino acids
    Molecular mass:
    34225 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HNRNPA1L2 Gene

Proteomics data for HNRNPA1L2 Gene at MOPED

Post-translational modifications for HNRNPA1L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HNRNPA1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPA1L2 Gene

Domains & Families for HNRNPA1L2 Gene

Gene Families for HNRNPA1L2 Gene

Protein Domains for HNRNPA1L2 Gene

Suggested Antigen Peptide Sequences for HNRNPA1L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q32P51

UniProtKB/Swiss-Prot:

RA1L2_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPA1L2: view

Function for HNRNPA1L2 Gene

Molecular function for HNRNPA1L2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.

Phenotypes for HNRNPA1L2 Gene

GenomeRNAi human phenotypes for HNRNPA1L2:
genes like me logo Genes that share phenotypes with HNRNPA1L2: view

Animal Model Products

CRISPR Products

miRNA for HNRNPA1L2 Gene

miRTarBase miRNAs that target HNRNPA1L2

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA1L2 Gene

Localization for HNRNPA1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPA1L2 Gene COMPARTMENTS Subcellular localization image for HNRNPA1L2 gene
Compartment Confidence
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for HNRNPA1L2 Gene

Pathways & Interactions for HNRNPA1L2 Gene

SuperPathways for HNRNPA1L2 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with HNRNPA1L2: view

Pathways by source for HNRNPA1L2 Gene

1 KEGG pathway for HNRNPA1L2 Gene

Interacting Proteins for HNRNPA1L2 Gene

Selected Interacting proteins: Q32P51-RA1L2_HUMAN for HNRNPA1L2 Gene via I2D

Gene Ontology (GO) - Biological Process for HNRNPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with HNRNPA1L2: view

No data available for SIGNOR curated interactions for HNRNPA1L2 Gene

Drugs & Compounds for HNRNPA1L2 Gene

No Compound Related Data Available

Transcripts for HNRNPA1L2 Gene

mRNA/cDNA for HNRNPA1L2 Gene

Unigene Clusters for HNRNPA1L2 Gene

Heterogeneous nuclear ribonucleoprotein A1-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA1L2 Gene

No ASD Table

Relevant External Links for HNRNPA1L2 Gene

GeneLoc Exon Structure for
HNRNPA1L2
ECgene alternative splicing isoforms for
HNRNPA1L2

Expression for HNRNPA1L2 Gene

mRNA expression in normal human tissues for HNRNPA1L2 Gene

Protein differential expression in normal tissues from HIPED for HNRNPA1L2 Gene

This gene is overexpressed in Cervix (11.9), Pancreas (10.1), Peripheral blood mononuclear cells (8.2), Nasal epithelium (7.7), and Blymphocyte (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HNRNPA1L2 Gene



SOURCE GeneReport for Unigene cluster for HNRNPA1L2 Gene Hs.447506

genes like me logo Genes that share expression patterns with HNRNPA1L2: view

Protein tissue co-expression partners for HNRNPA1L2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPA1L2 Gene

Orthologs for HNRNPA1L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPA1L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100848353 35
  • 92.81 (n)
  • 94.37 (a)
HNRNPA1L2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC608729 35
  • 88.33 (n)
  • 86.56 (a)
HNRNPA1L2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5803 35
  • 90.21 (n)
  • 93.12 (a)
Gm5803 16
Gm7729 36
  • 96 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia HNRNPA1L2 35
  • 98.23 (n)
  • 95.92 (a)
HNRNPA1L2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPA1L2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToMany
Species with no ortholog for HNRNPA1L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HNRNPA1L2 Gene

ENSEMBL:
Gene Tree for HNRNPA1L2 (if available)
TreeFam:
Gene Tree for HNRNPA1L2 (if available)

Paralogs for HNRNPA1L2 Gene

Paralogs for HNRNPA1L2 Gene

(13) SIMAP similar genes for HNRNPA1L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HNRNPA1L2: view

Variants for HNRNPA1L2 Gene

Sequence variations from dbSNP and Humsavar for HNRNPA1L2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs9536212 - 52,643,135(+) ATGAC(A/G)ACTTT reference, missense
rs186900 -- 52,632,578(-) ATATC(C/T)AACTA intron-variant
rs619222 -- 52,623,087(-) TGTCT(C/G)AATTA intron-variant
rs342768 -- 52,634,747(-) ACTCT(A/G)GGATA intron-variant
rs342769 -- 52,634,612(-) ATTAT(A/G)TTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA1L2 Gene

Variant ID Type Subtype PubMed ID
dgv1588n71 CNV Loss 21882294
nsv820041 CNV Gain 19587683
nsv900087 CNV Loss 21882294
nsv819201 CNV Gain 19587683

Variation tolerance for HNRNPA1L2 Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.46; 82.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPA1L2 Gene

HapMap Linkage Disequilibrium report
HNRNPA1L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

Disorders for HNRNPA1L2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HNRNPA1L2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dementia, frontotemporal
  • dementia, frontotemporal, with or without parkinsonism
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HNRNPA1L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPA1L2
genes like me logo Genes that share disorders with HNRNPA1L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPA1L2 Gene

Publications for HNRNPA1L2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Viral immune modulators perturb the human molecular network by common and unique strategies. (PMID: 22810585) Pichlmair A. … Superti-Furga G. (Nature 2012) 3

Products for HNRNPA1L2 Gene

Sources for HNRNPA1L2 Gene

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