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Aliases for HNRNPA1L2 Gene

Aliases for HNRNPA1L2 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A1-Like 2 2 3 5
  • HnRNP Core Protein A1-Like 2 4
  • HnRNP A1-Like 2 4
  • HNRNPA1L 4

External Ids for HNRNPA1L2 Gene

Previous GeneCards Identifiers for HNRNPA1L2 Gene

  • GC13P052092
  • GC13P053192
  • GC13P033905

Summaries for HNRNPA1L2 Gene

GeneCards Summary for HNRNPA1L2 Gene

HNRNPA1L2 (Heterogeneous Nuclear Ribonucleoprotein A1-Like 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is HNRNPA1.

UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

  • Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA1L2 Gene

Genomics for HNRNPA1L2 Gene

Regulatory Elements for HNRNPA1L2 Gene

Enhancers for HNRNPA1L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F052404 0.6 ENCODE 3.9 -211.8 -211796 2.3 ZSCAN5A KLF1 ZNF76 SIN3A YY1 ZFHX2 GLIS2 POLR2A PATZ1 SCRT2 TPTE2P2 HNRNPA1L2 THSD1 RNY4P24
GH13F052779 0.4 FANTOM5 1.5 +161.7 161722 0.1 PCDH8 HNRNPA1L2 LOC105370209 MIR759
GH13F052616 1.1 FANTOM5 ENCODE 0.8 +0.0 11 2.0 PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ALG11 TPTE2P2 UTP14C HNRNPA1L2 ENSG00000273723
GH13F052623 1.2 Ensembl ENCODE 0.4 +6.5 6529 1.2 CTCF PKNOX1 ZNF654 RFX1 MTA2 BMI1 RAD21 TBX21 GATA3 IKZF1 VPS36 TPTE2P2 PPIAP26 HNRNPA1L2 ENSG00000273723
GH13F052631 0.4 Ensembl 0.4 +13.9 13931 0.4 ZNF664 HNRNPA1L2 ENSG00000273723
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HNRNPA1L2 on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPA1L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001035855 130 2001 PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for HNRNPA1L2 Gene

Chromosome:
13
Start:
52,617,470 bp from pter
End:
52,643,796 bp from pter
Size:
26,327 bases
Orientation:
Plus strand

Genomic View for HNRNPA1L2 Gene

Genes around HNRNPA1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPA1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPA1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA1L2 Gene

Proteins for HNRNPA1L2 Gene

  • Protein details for HNRNPA1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q32P51-RA1L2_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A1-like 2
    Protein Accession:
    Q32P51
    Secondary Accessions:
    • Q5TBS2

    Protein attributes for HNRNPA1L2 Gene

    Size:
    320 amino acids
    Molecular mass:
    34225 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HNRNPA1L2 Gene

Post-translational modifications for HNRNPA1L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HNRNPA1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HNRNPA1L2 Gene

Domains & Families for HNRNPA1L2 Gene

Gene Families for HNRNPA1L2 Gene

Protein Domains for HNRNPA1L2 Gene

Suggested Antigen Peptide Sequences for HNRNPA1L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q32P51

UniProtKB/Swiss-Prot:

RA1L2_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPA1L2: view

Function for HNRNPA1L2 Gene

Molecular function for HNRNPA1L2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.

Gene Ontology (GO) - Molecular Function for HNRNPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with HNRNPA1L2: view

Phenotypes for HNRNPA1L2 Gene

GenomeRNAi human phenotypes for HNRNPA1L2:
genes like me logo Genes that share phenotypes with HNRNPA1L2: view

Animal Model Products

miRNA for HNRNPA1L2 Gene

miRTarBase miRNAs that target HNRNPA1L2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA1L2 Gene

Localization for HNRNPA1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPA1L2 Gene COMPARTMENTS Subcellular localization image for HNRNPA1L2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for HNRNPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA --
GO:0019013 viral nucleocapsid IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with HNRNPA1L2: view

Pathways & Interactions for HNRNPA1L2 Gene

SuperPathways for HNRNPA1L2 Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with HNRNPA1L2: view

Pathways by source for HNRNPA1L2 Gene

1 KEGG pathway for HNRNPA1L2 Gene

Interacting Proteins for HNRNPA1L2 Gene

Selected Interacting proteins: Q32P51-RA1L2_HUMAN for HNRNPA1L2 Gene via IID

Gene Ontology (GO) - Biological Process for HNRNPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006810 transport IEA --
GO:0008380 RNA splicing IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with HNRNPA1L2: view

No data available for SIGNOR curated interactions for HNRNPA1L2 Gene

Transcripts for HNRNPA1L2 Gene

mRNA/cDNA for HNRNPA1L2 Gene

Unigene Clusters for HNRNPA1L2 Gene

Heterogeneous nuclear ribonucleoprotein A1-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA1L2 Gene

No ASD Table

Relevant External Links for HNRNPA1L2 Gene

GeneLoc Exon Structure for
HNRNPA1L2
ECgene alternative splicing isoforms for
HNRNPA1L2

Expression for HNRNPA1L2 Gene

mRNA expression in normal human tissues for HNRNPA1L2 Gene

Protein differential expression in normal tissues from HIPED for HNRNPA1L2 Gene

This gene is overexpressed in Cervix (11.9), Pancreas (10.1), Peripheral blood mononuclear cells (8.2), Nasal epithelium (7.7), and Blymphocyte (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HNRNPA1L2 Gene



Protein tissue co-expression partners for HNRNPA1L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HNRNPA1L2 Gene:

HNRNPA1L2

SOURCE GeneReport for Unigene cluster for HNRNPA1L2 Gene:

Hs.447506
genes like me logo Genes that share expression patterns with HNRNPA1L2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPA1L2 Gene

Orthologs for HNRNPA1L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPA1L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPA1L2 34 35
  • 98.23 (n)
mouse
(Mus musculus)
Mammalia Gm7729 35
  • 96 (a)
ManyToMany
Gm5803 34 16
  • 90.21 (n)
cow
(Bos Taurus)
Mammalia LOC100848353 34
  • 92.81 (n)
HNRNPA1L2 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC608729 34
  • 88.33 (n)
HNRNPA1L2 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 88 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia HNRNPA1L2 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 77 (a)
OneToMany
Species where no ortholog for HNRNPA1L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HNRNPA1L2 Gene

ENSEMBL:
Gene Tree for HNRNPA1L2 (if available)
TreeFam:
Gene Tree for HNRNPA1L2 (if available)

Paralogs for HNRNPA1L2 Gene

(13) SIMAP similar genes for HNRNPA1L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HNRNPA1L2: view

Variants for HNRNPA1L2 Gene

Sequence variations from dbSNP and Humsavar for HNRNPA1L2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10661534 -- 52,639,694(+) GTCTC(-/A/AA)AAAAA intron-variant
rs111605069 -- 52,619,885(+) CACTG(C/T)ACTCT intron-variant
rs111730720 -- 52,636,240(+) ACTTT(C/T)GTGTA intron-variant
rs111767403 -- 52,634,901(+) AAAAG(C/T)GTGAG intron-variant
rs111843573 -- 52,620,307(+) ATCTT(A/T)GGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA1L2 Gene

Variant ID Type Subtype PubMed ID
dgv1653n100 CNV gain 25217958
esv3632103 CNV loss 21293372
esv3892344 CNV loss 25118596
esv3892345 CNV gain 25118596
nsv1044949 CNV gain 25217958
nsv819201 CNV gain 19587683
nsv820041 CNV gain 19587683
nsv976119 CNV duplication 23825009

Variation tolerance for HNRNPA1L2 Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.46; 82.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPA1L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNRNPA1L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA1L2 Gene

Disorders for HNRNPA1L2 Gene

Relevant External Links for HNRNPA1L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPA1L2

No disorders were found for HNRNPA1L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPA1L2 Gene

Publications for HNRNPA1L2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for HNRNPA1L2 Gene

Sources for HNRNPA1L2 Gene

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