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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNRNPA1L2 Gene

protein-coding   GIFtS: 41
GCID: GC13P053192

Heterogeneous Nuclear Ribonucleoprotein A1-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heterogeneous Nuclear Ribonucleoprotein A1-Like 21 2
HnRNP A1-Like 22 3
HnRNP Core Protein A1-Like 22 3
HNRNPA1L3

External Ids:    HGNC: 270671   Entrez Gene: 1449832   Ensembl: ENSG000001396757   UniProtKB: Q32P513   

Export aliases for HNRNPA1L2 gene to outside databases

Previous GC identifers: GC13P052092 GC13P033905


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HNRNPA1L2 Gene: 
HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1-like 2) is a protein-coding gene. Diseases associated with HNRNPA1L2 include spinal cord disease, and spastic paraparesis, and among its related super-pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is HNRNPDL.

UniProtKB/Swiss-Prot: RA1L2_HUMAN, Q32P51
Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus
to the cytoplasm and may modulate splice site selection (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNRNPA1L2 gene promoter:
         STAT5B   STAT1   AML1a   STAT4   STAT1beta   STAT5A   STAT1alpha   STAT2   STAT3   TGIF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HNRNPA1L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPA1L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.3   HGNC cytogenetic band: 13q14.3

HNRNPA1L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPA1L2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P053192:  view genomic region     (about GC identifiers)

Start:
53,191,605 bp from pter      End:
53,217,919 bp from pter
Size:
26,315 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RA1L2_HUMAN, Q32P51 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein A1-like 2  
Size: 320 amino acids; 34225 Da
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity)
Secondary accessions: Q5TBS2

Explore the universe of human proteins at neXtProt for HNRNPA1L2: NX_Q32P51

Explore proteomics data for HNRNPA1L2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q32P51

  • HNRNPA1L2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HNRNPA1L2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001011724.1  NP_001011725.1  

    ENSEMBL proteins: 
     ENSP00000350090   ENSP00000341285   ENSP00000381119  

    Human Recombinant Protein Products for HNRNPA1L2: 
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    Browse Sino Biological Cell Lysates 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005681spliceosomal complex IEA--
    GO:0005737cytoplasm IEA--

    HNRNPA1L2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR021662 HnRNPA1
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q32P51

    ProtoNet protein and cluster: Q32P51

    UniProtKB/Swiss-Prot: RA1L2_HUMAN, Q32P51
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    HNRNPA1L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RA1L2_HUMAN, Q32P51
    Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus
    to the cytoplasm and may modulate splice site selection (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
         
    HNRNPA1L2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HNRNPA1L2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Spliceosome0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for HNRNPA1L2):
        Spliceosome


    HNRNPA1L2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HNRNPA1L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/30 Interacting proteins for HNRNPA1L2 (Q32P513 ENSP000003500904) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUFUQ9UMX13I2D: score=3 
    PIAS1O759253I2D: score=2 
    ARRB1P494073I2D: score=1 
    ESR1P033723I2D: score=1 
    GRID2O434243I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--
    GO:0051028mRNA transport IEA--

    HNRNPA1L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HNRNPA1L2 (RA1L2)

    Search CenterWatch for drugs/clinical trials and news about HNRNPA1L2 / RA1L2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HNRNPA1L2 gene (2 alternative transcripts): 
    NM_001011724.1  NM_001011725.1  

    Unigene Cluster for HNRNPA1L2:

    Heterogeneous nuclear ribonucleoprotein A1-like 2
    Hs.447506  [show with all ESTs]
    Unigene Representative Sequence: AK126454
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357495(uc021rjy.1) ENST00000342657(uc001vgx.1) ENST00000398039(uc021rjx.1 uc001vgy.1 uc001vgz.1)

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    hsa-miR-649 hsa-miR-646 hsa-miR-636
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    Additional mRNA sequence: 

    AK091082.1 AK094423.1 AK123081.1 AK123159.1 AK126454.1 BC082242.1 BC108266.1 

    24/42 DOTS entries (see all 42):

    DT.100725837  DT.120775453  DT.95264235  DT.121643552  DT.100725742  DT.101964105  DT.100725794  DT.95264326 
    DT.100725829  DT.100837162  DT.91741698  DT.95264225  DT.100888711  DT.120775430  DT.306096  DT.451790 
    DT.85105360  DT.91698577  DT.91741699  DT.92002214  DT.100046018  DT.100725796  DT.120775439  DT.120775455 

    24/37 AceView cDNA sequences (see all 37):

    AK126454 BQ549643 BQ425201 BM465470 BM721161 CB153408 BU074334 BC082242 
    AK091082 AK123159 BE902520 BQ549161 AA169363 BG757899 AL598686 AK094423 
    BE899301 BM679584 BG743252 BX487651 BM710503 AA101679 AI003057 AI751729 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNRNPA1L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HNRNPA1L2 Expression
    About this image


    See HNRNPA1L2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNRNPA1L2

    SOURCE GeneReport for Unigene cluster: Hs.447506
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HNRNPA1L2 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm58031 , 5 predicted gene 58031, 5 90.21(n)1
    93.12(a)1
      15 (8.54 cM)5
    5450911  NM_001165971.11  NP_001159443.11 
     227138685 
    chicken
    (Gallus gallus)
    Aves --
    --
    92(a)
    1 → many
    JH375601.1(21-2529)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    76(a)
    1 → many
    2(71258665-71268894)


    ENSEMBL Gene Tree for HNRNPA1L2 (if available)
    TreeFam Gene Tree for HNRNPA1L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HNRNPA1L2 gene
    HNRNPDL2  HNRNPA12  HNRNPD2  HNRNPA02  HNRNPA32  HNRNPAB2  DAZAP12  HNRNPA2B12  
    13 SIMAP similar genes for HNRNPA1L2 using alignment to 1 protein entry:     RA1L2_HUMAN:
    HNRPA1    D10S102    HNRNPA1    HNRNPA2B1    HNRNPA0    HNRNPA3
    HNRNPAB    HNRPA3    HNRNPD    HNRPDL    MSI1    DAZAP1
    MSI2

    HNRNPA1L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/579 SNPs in HNRNPA1L2 are shown (see all 579)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1462575381,2
    --53189747(+) ATTGCA/GCAATA 2 -- us2k10--------
    rs1147294571,2
    C,F--53189770(+) TCAATA/CACAAT 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1392832351,2
    --53189814(+) GAATTG/TTTTGT 2 -- us2k10--------
    rs740873581,2
    C,F--53190034(+) TAGCAA/GCTCTC 2 -- us2k12Minor allele frequency- G:0.07WA 120
    rs1819465091,2
    --53190036(+) GCAACC/TCTCTG 2 -- us2k10--------
    rs1858486011,2
    --53190120(+) GGCCCC/TGTGAC 2 -- us2k10--------
    rs757683171,2
    C--53190150(+) TGAAAC/TGAAAG 2 -- us2k10--------
    rs1465675591,2
    --53190316(+) CACGAC/GGTCAA 2 -- us2k10--------
    rs1903709791,2
    --53190343(+) TGGCCA/GATGTG 2 -- us2k10--------
    rs1810323871,2
    --53190365(+) TCTCTA/CCTAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HNRNPA1L2 (53191605 - 53217919 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HNRNPA1L2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv900087CNV Loss21882294
    dgv1588n71CNV Loss21882294
    nsv819201CNV Gain19587683
    nsv820041CNV Gain19587683

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    6 diseases for HNRNPA1L2:    About MalaCards
    spinal cord disease    spastic paraparesis    tropical spastic paraparesis    spasticity
    muscular atrophy    breast cancer


    HNRNPA1L2 for disorders           About GeneDecksing


    Export disorders for HNRNPA1L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNRNPA1L2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with HNRNPA1L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Viral immune modulators perturb the human molecular ne twork by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Characterization of the protein ubiquitination respons e induced by Doxorubicin. (PubMed id 22536838)1 Mandili G....Turrini F. (2012)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 144983 HGNC: 27067 AceView: LOC144983 Ensembl:ENSG00000139675 euGenes: HUgn144983
    ECgene: HNRNPA1L2 Kegg: 144983 H-InvDB: HNRNPA1L2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNRNPA1L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPA1L2 gene:
    Search GeneIP for patents involving HNRNPA1L2

    GeneCards and IP:
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