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HNRNPA1 Gene

protein-coding   GIFtS: 64
GCID: GC12P054674

Heterogeneous Nuclear Ribonucleoprotein A1


(Previous symbol: HNRPA1)
  See HNRNPA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterogeneous Nuclear Ribonucleoprotein A11 2     Heterogeneous Nuclear Ribonucleoprotein A1B Protein2
HNRPA11 2 3     Heterogeneous Nuclear Ribonucleoprotein B2 Protein2
Helix-Destabilizing Protein2 3     Heterogeneous Nuclear Ribonucleoprotein Core Protein A12
Single-Strand RNA-Binding Protein2 3     hnRNP-A12
HnRNP A12 3     HnRNP A1-Like 32
HnRNP Core Protein A12 3     HnRNP Core Protein A1-Like 32
ALS202 5     Nuclear Ribonucleoprotein Particle A1 Protein2
IBMPFD32 5     Putative Heterogeneous Nuclear Ribonucleoprotein A1-Like 32
ALS192     Single-Strand DNA-Binding Protein UP12
HNRPA1L32     

External Ids:    HGNC: 50311   Entrez Gene: 31782   Ensembl: ENSG000001354867   OMIM: 1640175   UniProtKB: P096513   

Export aliases for HNRNPA1 gene to outside databases

Previous GC identifers: GC12P052961 GC12P051713


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNRNPA1 Gene:
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins
(hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These
proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other
aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to
shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.
The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most
abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other
hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9
domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the
packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may
modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial
protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene
but only two transcripts are fully described. These variants have multiple alternative transcription initiation
sites and multiple polyA sites. (provided by RefSeq, Jul 2008)

GeneCards Summary for HNRNPA1 Gene:
HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) is a protein-coding gene. Diseases associated with HNRNPA1 include amyotrophic lateral sclerosis 20, and inclusion body myopathy wtih early-onset paget disease without frontotemporal dementia 3. GO annotations related to this gene include single-stranded DNA binding and RNA binding. An important paralog of this gene is HNRNPD.

UniProtKB/Swiss-Prot: ROA1_HUMAN, P09651
Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus
to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication

Gene Wiki entry for HNRNPA1 (Heterogeneous nuclear ribonucleoprotein A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNRNPA1 gene promoter:
         AML1a   E2F-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRNPA1 promoter sequence
   Search Chromatin IP Primers for HNRNPA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNRNPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.1   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.1

HNRNPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPA1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054674:  view genomic region     (about GC identifiers)

Start:
54,673,977 bp from pter      End:
54,680,872 bp from pter
Size:
6,896 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ROA1_HUMAN, P09651 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein A1  
Size: 372 amino acids; 38747 Da
Subunit: Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex
containing untranslated mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of
HCV RNA
Selected PDB 3D structures from and Proteopedia for HNRNPA1 (see all 16):
1HA1 (3D)        1L3K (3D)        1PGZ (3D)        1PO6 (3D)        1U1K (3D)        1U1L (3D)    
Secondary accessions: A8K4Z8 Q3MIB7 Q6PJZ7
Alternative splicing: 3 isoforms:  P09651-1   P09651-2   P09651-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HNRNPA1: NX_P09651

Explore proteomics data for HNRNPA1 at MOPED

Post-translational modifications: 

  • Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine1
  • Sumoylated1
  • Ubiquitination2 at Lys3, Lys8, Lys15, Lys52, Lys78, Lys350
  • Modification sites at PhosphoSitePlus

  • See HNRNPA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002127.1  NP_112420.1  

    ENSEMBL proteins: 
     ENSP00000448617   ENSP00000448229   ENSP00000449913   ENSP00000341826   ENSP00000448117  
     ENSP00000333504   ENSP00000447260   ENSP00000447782   ENSP00000448917   ENSP00000446486  
    Reactome Protein details: P09651

    HNRNPA1 Human Recombinant Protein Products:

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    Novus Biologicals HNRNPA1 Proteins
    Novus Biologicals HNRNPA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HNRNPA1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HNRNPA1 

    HNRNPA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HNRNPA1
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    Abcam antibodies for HNRNPA1
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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for HNRNPA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P09651

    ProtoNet protein and cluster: P09651

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: ROA1_HUMAN, P09651
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with HNRNPA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROA1_HUMAN, P09651
    Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus
    to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003697single-stranded DNA binding IDA8521471
    GO:0003723RNA binding TAS8521471
    GO:0003727single-stranded RNA binding IC8521471
         
    Find genes that share ontologies with HNRNPA1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HNRNPA1:
     Increased HPV18 LCR reporter a  Low eccentricity cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HNRNPA1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HNRNPA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HNRNPA1

    miRNA
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    miRTarBase miRNAs that target HNRNPA1:
    hsa-mir-96-5p (MIRT048737), hsa-mir-19b-3p (MIRT031226), hsa-mir-324-5p (MIRT043217), hsa-mir-1 (MIRT024037), hsa-mir-22-5p (MIRT038961), hsa-mir-25-3p (MIRT050353), hsa-mir-1229-3p (MIRT036356), hsa-mir-30a-5p (MIRT028678), hsa-mir-615-3p (MIRT039996), hsa-mir-186-5p (MIRT045060), hsa-mir-1296-5p (MIRT036122), hsa-mir-484 (MIRT042186), hsa-mir-1260b (MIRT052722), hsa-mir-339-5p (MIRT042762), hsa-mir-197-3p (MIRT048099), hsa-mir-194-5p (MIRT044875)

    Block miRNA regulation of human, mouse, rat HNRNPA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNRNPA1 (see all 52):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-300 hsa-miR-330-5p hsa-miR-411 hsa-miR-15a hsa-miR-503 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HNRNPA1
    Predesigned siRNA for gene silencing in human, mouse, rat HNRNPA1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): HNRNPA1 (NM_002136)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPA1
    Addgene plasmids for HNRNPA1 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HNRNPA1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ROA1_HUMAN, P09651: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated
    mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes.
    In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication
    dependent manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with HNRNPA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNRNPA1 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Translational Control
    Translational Control
    4Spliceosome
    Spliceosome
    5Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity


    Find genes that share SuperPaths with HNRNPA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HNRNPA1
        Telomere Extension by Telomerase

    1 Cell Signaling Technology (CST) Pathway for HNRNPA1
        Translational Control

    2 BioSystems Pathways for HNRNPA1
        mRNA processing
    Coregulation of Androgen receptor activity

    2 Reactome Pathways for HNRNPA1
        mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA


    1 Kegg Pathway  (Kegg details for HNRNPA1):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HNRNPA1
    Interactions:

        GeneGlobe Interaction Network for HNRNPA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HNRNPA1 (P096511, 2, 3 ENSP000003418264) via UniProtKB, MINT, STRING, and/or I2D (see all 915)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62718 MINT-62794 MINT-62620 I2D: score=4 STRING: ENSP00000387477
    ENSG00000231825P486342, 3, ENSP000004153634MINT-62718 MINT-62794 MINT-62620 I2D: score=4 STRING: ENSP00000415363
    ABHD16AO958702, 3, ENSP000003792824MINT-62698 MINT-62774 MINT-62600 I2D: score=3 STRING: ENSP00000379282
    ENSG00000236063O958702, 3, ENSP000004069654MINT-62698 MINT-62774 MINT-62600 I2D: score=3 STRING: ENSP00000406965
    ENSG00000206427P486342, 3MINT-62718 MINT-62794 MINT-62620 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000380alternative mRNA splicing, via spliceosome IEA--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing TAS8521471
    GO:0006405RNA export from nucleus IC8521471
    GO:0008219cell death IEA--

    Find genes that share ontologies with HNRNPA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HNRNPA1 (ROA1)

    1 Novoseek inferred chemical compound relationship for HNRNPA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 1 1656054 (1)



    Find genes that share compounds with HNRNPA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HNRNPA1 gene (2 alternative transcripts): 
    NM_002136.2  NM_031157.2  

    Unigene Cluster for HNRNPA1:

    Heterogeneous nuclear ribonucleoprotein A1
    Hs.546261  [show with all ESTs]
    Unigene Representative Sequence: NM_031157
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546500(uc001sfm.3 uc001sfn.3 uc001sfo.3) ENST00000547708
    ENST00000547566 ENST00000547870 ENST00000340913(uc001sfl.3 uc009znj.1)
    ENST00000551702 ENST00000330752 ENST00000547276 ENST00000548688 ENST00000550994
    ENST00000550482 ENST00000551679 ENST00000551665 ENST00000551803
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HNRNPA1 (see all 52):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-300 hsa-miR-330-5p hsa-miR-411 hsa-miR-15a hsa-miR-503 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPA1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): HNRNPA1 (NM_002136)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPA1
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    Addgene plasmids for HNRNPA1 
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      QuantiTect SYBR Green Assays in human, mouse, rat HNRNPA1
      QuantiFast Probe-based Assays in human, mouse, rat HNRNPA1

    Additional mRNA sequence: 

    AK129814.1 AK291113.1 AK298176.1 AK303303.1 AK308679.1 BC002355.2 BC004945.1 BC009600.1 
    BC012158.1 BC020442.2 BC033714.1 BC035253.1 BC052296.1 BC070315.1 BC071945.1 BC073162.1 
    BC074502.1 BC078165.1 BC103707.1 BC104236.1 BC104237.1 BC121133.2 U00947.1 X04347.1 
    X06747.1 X79536.1 

    Selected DOTS entries (see all 171):

    DT.95264221  DT.100725784  DT.100725828  DT.100725762  DT.92032774  DT.91645718  DT.100725796  DT.95264225 
    DT.85105360  DT.100725748  DT.100859202  DT.100725751  DT.91698577  DT.92472227  DT.100046018  DT.100847445 
    DT.100725794  DT.91898151  DT.100725817  DT.100045999  DT.100725742  DT.92002214  DT.100837162  DT.100725785 

    Selected AceView cDNA sequences (see all 3156):

    BQ213931 AI131389 BQ648602 CA418883 BE792794 BM457576 CA841396 BM799252 
    BE794042 BI093968 BG913476 BQ422343 CD676982 BM800180 BM817560 BQ233340 
    BX444574 CA405673 AI141447 BM917510 AA975528 CB269770 BQ182735 BQ888498 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                -     -     -                                                                                 
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for HNRNPA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HNRNPA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTTGATTG
    HNRNPA1 Expression
    About this image


    HNRNPA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    HNRNPA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNRNPA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546261
        Custom PCR Arrays for HNRNPA1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HNRNPA1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpa15 heterogeneous nuclear ribonucleoprotein A1   --   15 (58.58 cM) 103240432 
    chicken
    (Gallus gallus)
    Aves LOC1008596271 heterogeneous nuclear ribonucleoprotein A3 homolog more 76.72(n)
    84.91(a)
      100859627  XM_004942720.1  XP_004942777.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    87(a)
    1 → many
    2(71258665-71268894)
    African clawed frog
    (Xenopus laevis)
    Amphibia hnrpa1-prov2 heterogeneous ribonuclear particle protein 77.67(n)    BC045260.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.7082 Danio rerio mRNA similar to heterogeneous nuclear ribonucleoprotein more 78.42(n)    BC044442.1 


    ENSEMBL Gene Tree for HNRNPA1 (if available)
    TreeFam Gene Tree for HNRNPA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HNRNPA1 gene
    HNRNPD2  HNRNPDL2  HNRNPA32  HNRNPA02  HNRNPAB2  HNRNPA1L22  HNRNPA2B12  
    Selected SIMAP similar genes for HNRNPA1 using alignment to 7 protein entries:     ROA1_HUMAN (see all proteins) (see all similar genes):
    HNRPA1    D10S102    HNRNPA2B1    HNRNPA1L2    HNRNPA3    HNRPA3
    BOLL    RBMXL3    HNRNPA0    CIRBP    HNRNPD    HNRNPAB
    RBMXL2    RBMX    MSI2    HNRNPDL    ELAVL1    PABPC4

    Find genes that share paralogs with HNRNPA1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for HNRNPA1 (see all 85)
    PGOHUM00000261082 PGOHUM00000261085 PGOHUM00000261086 PGOHUM00000261104 PGOHUM00000261106


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HNRNPA1 (see all 108)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0705904
    Amyotrophic lateral sclerosis 20 (ALS20)4--see VAR_0705902 N S mis40--------
    VAR_0705884
    Amyotrophic lateral sclerosis 20 (ALS20)4--see VAR_0705882 D N mis40--------
    VAR_0705894
    Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 (IBMPFD3)4--see VAR_0705892 D V mis40--------
    rs1145817981,2
    C,F--54676109(+) ATTTAG/TTAAGG 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1828669321,2
    C--54676114(+) GTAAGG/TGTTCC 2 -- int10--------
    rs2021190451,2
    C--54676165(+) TTTTT-/TAGTTC 2 -- int10--------
    rs2006430191,2
    --54676218(+) GAAGTG/TAGAAA 4 V syn10--------
    rs1997634501,2
    --54676230(+) GCCCTC/GTCAAA 4 L syn10--------
    rs2007079181,2
    C,F--54676233(+) CTGTCA/GAAGCA 4 S syn11Minor allele frequency- G:0.00EU 1323
    rs780023761,2
    C--54676311(+) TTTGAG/TTTACT 2 -- int10--------

    HapMap Linkage Disequilibrium report for HNRNPA1 (54673977 - 54680872 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HNRNPA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv25123CNV Loss19812545
    nsv832420CNV Loss17160897

    Human Gene Mutation Database (HGMD): HNRNPA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPA1
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 164017   
    OMIM disorders: 615424  615426  
    UniProtKB/Swiss-Prot: ROA1_HUMAN, P09651
  • Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3
    (IBMPFD3) [MIM:615424]: An autosomal dominant disease characterized by disabling muscle weakness clinically
    resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and
    premature frontotemporal dementia. Clinical features show incomplete penetrance. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Amyotrophic lateral sclerosis 20 (ALS20) [MIM:615426]: A neurodegenerative disorder affecting upper motor
    neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis.
    Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal
    tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and
    deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be
    multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 8 diseases for HNRNPA1:    
    About MalaCards
    amyotrophic lateral sclerosis 20    inclusion body myopathy wtih early-onset paget disease without frontotemporal dementia 3    spinal cord disease    human t-cell leukemia virus type 2
    inclusion body myopathy with early-onset paget disease and frontotemporal dementia 1    oculopharyngeal muscular dystrophy    frontotemporal dementia    amyotrophic lateral sclerosis

    2 diseases from the University of Copenhagen DISEASES database for HNRNPA1:
    Tropical spastic paraparesis     Spinal cord disease

    Find genes that share disorders with HNRNPA1           About GenesLikeMe

    7 Novoseek inferred disease relationships for HNRNPA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 37.6 2 11893730 (1), 7474099 (1)
    mimicry 25.7 2 12707436 (1), 16600502 (1)
    immunodeficiency 21.2 2 19737937 (1), 19625255 (1)
    colorectal cancer 8.21 1 19715280 (1)
    tumors 0 1 9865741 (1)
    prostate cancer 0 1 17110431 (1)
    cancer 0 1 20010808 (1)

    Genetic Association Database (GAD): HNRNPA1
    Human Genome Epidemiology (HuGE) Navigator: HNRNPA1 (3 documents)

    Export disorders for HNRNPA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HNRNPA1 gene, integrated from 10 sources (see all 288):
    (articles sorted by number of sources associating them with HNRNPA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human heterogeneous nuclear ribonucleoprotein A1 gene (HNRPA1) to chromosome 12q13.1 by cDNA competitive in situ hybridization. (PubMed id 1733858)1, 3, 9 Saccone S....Della Valle G. (Genomics 1992)
    2. Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein. (PubMed id 1691095)1, 2, 9 Buvoli M.... Riva S. (EMBO J. 1990)
    3. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. (PubMed id 23455423)1, 2 Kim H.J....Taylor J.P. (Nature 2013)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. (PubMed id 17229681)1, 2 Kim C.S.... Jang S.K. (J. Virol. 2007)
    6. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. (PubMed id 15161980)1, 2 Li T.... Chock P.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    9. Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)1, 2 Ong S.E.... Mann M. (Nat. Methods 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3178 HGNC: 5031 AceView: HNRPA1 Ensembl:ENSG00000135486 euGenes: HUgn3178
    ECgene: HNRNPA1 Kegg: 3178 H-InvDB: HNRNPA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HNRNPA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HNRNPA1 gene:
    Search GeneIP for patents involving HNRNPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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