Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNRNPA1 Gene

protein-coding   GIFtS: 63
GCID: GC12P054674

Heterogeneous Nuclear Ribonucleoprotein A1


(Previous symbol: HNRPA1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heterogeneous Nuclear Ribonucleoprotein A11 2     Heterogeneous Nuclear Ribonucleoprotein B2 Protein2
HNRPA11 2 3 5     Heterogeneous Nuclear Ribonucleoprotein Core Protein A12
Helix-Destabilizing Protein2 3     hnRNP-A12
Single-Strand RNA-Binding Protein2 3     HnRNP A1-Like 32
HnRNP A12 3     HnRNP Core Protein A1-Like 32
HnRNP Core Protein A12 3     Nuclear Ribonucleoprotein Particle A1 Protein2
HNRPA1L32     Putative Heterogeneous Nuclear Ribonucleoprotein A1-Like 32
Heterogeneous Nuclear Ribonucleoprotein A1B Protein2     Single-Strand DNA-Binding Protein UP12

External Ids:    HGNC: 50311   Entrez Gene: 31782   Ensembl: ENSG000001354867   OMIM: 1640175   UniProtKB: P096513   

Export aliases for HNRNPA1 gene to outside databases

Previous GC identifers: GC12P052961 GC12P051713


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HNRNPA1 Gene:
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins
(hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These
proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other
aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to
shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.
The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most
abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other
hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9
domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the
packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may
modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial
protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene
but only two transcripts are fully described. These variants have multiple alternative transcription initiation
sites and multiple polyA sites. (provided by RefSeq, Jul 2008)

GeneCards Summary for HNRNPA1 Gene: 
HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) is a protein-coding gene. Diseases associated with HNRNPA1 include human t-cell leukemia virus type 2, and oculopharyngeal muscular dystrophy, and among its related super-pathways are mRNA Processing and Generic Transcription Pathway. GO annotations related to this gene include single-stranded DNA binding and RNA binding. An important paralog of this gene is HNRNPDL.

UniProtKB/Swiss-Prot: ROA1_HUMAN, P09651
Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus
to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication

Gene Wiki entry for HNRNPA1 (Heterogeneous nuclear ribonucleoprotein A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNRNPA1 gene promoter:
         AML1a   E2F-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRNPA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HNRNPA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.1   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.1

HNRNPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPA1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054674:  view genomic region     (about GC identifiers)

Start:
54,673,977 bp from pter      End:
54,680,872 bp from pter
Size:
6,896 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ROA1_HUMAN, P09651 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein A1  
Size: 372 amino acids; 38747 Da
Subunit: Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB,
ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3,
NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated
mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA
Subcellular location: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated
mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes.
In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication
dependent manner
6/16 PDB 3D structures from and Proteopedia for HNRNPA1 (see all 16):
1HA1 (3D)        1L3K (3D)        1PGZ (3D)        1PO6 (3D)        1U1K (3D)        1U1L (3D)    
Secondary accessions: A8K4Z8 Q3MIB7 Q6PJZ7
Alternative splicing: 3 isoforms:  P09651-1   P09651-2   P09651-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HNRNPA1: NX_P09651

Explore proteomics data for HNRNPA1 at MOPED 

Post-translational modifications:

  • UniProtKB: Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine
  • UniProtKB: Sumoylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09651

  • HNRNPA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HNRNPA1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002127.1  NP_112420.1  

    ENSEMBL proteins: 
     ENSP00000448617   ENSP00000448229   ENSP00000449913   ENSP00000341826   ENSP00000448117  
     ENSP00000333504   ENSP00000447260   ENSP00000447782   ENSP00000448917   ENSP00000446486  
    Reactome Protein details: P09651
    Human Recombinant Protein Products for HNRNPA1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for HNRNPA1
    OriGene Protein Over-expression Lysate for HNRNPA1
    OriGene MassSpec for HNRNPA1 
    OriGene Custom Protein Services for HNRNPA1
    GenScript Custom Purified and Recombinant Proteins Services for HNRNPA1
    Novus Biologicals HNRNPA1 Proteins
    Novus Biologicals HNRNPA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HNRNPA1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    HNRNPA1 for ontologies           About GeneDecksing



    HNRNPA1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HNRNPA1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for HNRNPA1  (hnRNP A1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HNRNPA1
    GenScript Custom Superior Antibodies Services for HNRNPA1
    Novus Biologicals HNRNPA1 Antibodies
    Abcam antibodies for HNRNPA1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for HNRNPA1
    LSBio Antibodies in human, mouse, rat for HNRNPA1 

    Assay Products for HNRNPA1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HNRNPA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HNRNPA1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P09651

    ProtoNet protein and cluster: P09651

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: ROA1_HUMAN, P09651
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    HNRNPA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROA1_HUMAN, P09651
    Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus
    to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003697single-stranded DNA binding IDA8521471
    GO:0003723RNA binding TAS8521471
    GO:0003727single-stranded RNA binding IC8521471
         
    HNRNPA1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HNRNPA1:
     Increased HPV18 LCR reporter a  Low eccentricity cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HNRNPA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HNRNPA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HNRNPA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HNRNPA1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HNRNPA1
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRNPA1 (see all 52):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-300 hsa-miR-330-5p hsa-miR-411 hsa-miR-15a hsa-miR-503 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HNRNPA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HNRNPA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HNRNPA1
    Sirion Biotech Customized adenovirus for overexpression of HNRNPA1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HNRNPA1 (see all 15)
    OriGene ORF clones in mouse, rat for HNRNPA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HNRNPA1 (NM_002136)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPA1
    Sirion Biotech Customized lentivirus for stable overexpression of HNRNPA1 
                         Customized lentivirus expression plasmids for stable overexpression of HNRNPA1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HNRNPA1
    Search LifeMap BioReagents cell lines for HNRNPA1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HNRNPA1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA processing0.46
    mRNA Splicing - Major Pathway0.82
    Spliceosome0.31
    2Generic Transcription Pathway
    Gene Expression0.47
    3Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity
    4Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HNRNPA1
        Translational Control

    2 BioSystems Pathways for HNRNPA1
        mRNA processing
    Coregulation of Androgen receptor activity

    5        Reactome Pathways for HNRNPA1
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA


    1         Kegg Pathway  (Kegg details for HNRNPA1):
        Spliceosome


    HNRNPA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HNRNPA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/874 Interacting proteins for HNRNPA1 (P096512, 3 ENSP000003418264) via UniProtKB, MINT, STRING, and/or I2D (see all 874)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62718 MINT-62794 MINT-62620 I2D: score=4 STRING: ENSP00000387477
    ENSG00000231825P486342, 3, ENSP000004153634MINT-62718 MINT-62794 MINT-62620 I2D: score=4 STRING: ENSP00000415363
    ABHD16AO958702, 3, ENSP000003792824MINT-62698 MINT-62774 MINT-62600 I2D: score=3 STRING: ENSP00000379282
    ENSG00000236063O958702, 3, ENSP000004069654MINT-62698 MINT-62774 MINT-62600 I2D: score=3 STRING: ENSP00000406965
    ENSG00000206427P486342, 3MINT-62718 MINT-62794 MINT-62620 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000380alternative mRNA splicing, via spliceosome IEA--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing TAS8521471
    GO:0006405RNA export from nucleus IC8521471
    GO:0008380RNA splicing TAS--

    HNRNPA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HNRNPA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HNRNPA1 (ROA1)

    1 Novoseek inferred chemical compound relationship for HNRNPA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 1 1656054 (1)

    Search CenterWatch for drugs/clinical trials and news about HNRNPA1 / ROA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HNRNPA1 gene (2 alternative transcripts): 
    NM_002136.2  NM_031157.2  

    Unigene Cluster for HNRNPA1:

    Heterogeneous nuclear ribonucleoprotein A1
    Hs.546261  [show with all ESTs]
    Unigene Representative Sequence: NM_031157
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546500(uc001sfm.3 uc001sfn.3 uc001sfo.3) ENST00000547708
    ENST00000547566 ENST00000547870 ENST00000340913(uc001sfl.3 uc009znj.1)
    ENST00000551702 ENST00000330752 ENST00000547276 ENST00000548688 ENST00000550994
    ENST00000550482 ENST00000551679 ENST00000551665 ENST00000551803
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HNRNPA1
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRNPA1 (see all 52):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-300 hsa-miR-330-5p hsa-miR-411 hsa-miR-15a hsa-miR-503 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidHNRNPA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HNRNPA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HNRNPA1
    Clone
    Products:
         
    OriGene clones in human, mouse for HNRNPA1 (see all 15)
    OriGene ORF clones in mouse, rat for HNRNPA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HNRNPA1 (NM_002136)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRNPA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPA1
    Sirion Biotech Customized lentivirus for stable overexpression of HNRNPA1 
                         Customized lentivirus expression plasmids for stable overexpression of HNRNPA1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HNRNPA1
    OriGene qSTAR qPCR primer pairs in human, mouse for HNRNPA1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HNRNPA1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HNRNPA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRNPA1

    Additional mRNA sequence: 

    AK129814.1 AK291113.1 AK298176.1 AK303303.1 AK308679.1 BC002355.2 BC004945.1 BC009600.1 
    BC012158.1 BC020442.2 BC033714.1 BC035253.1 BC052296.1 BC070315.1 BC071945.1 BC073162.1 
    BC074502.1 BC078165.1 BC103707.1 BC104236.1 BC104237.1 BC121133.2 U00947.1 X04347.1 
    X06747.1 X79536.1 

    24/171 DOTS entries (see all 171):

    DT.95264221  DT.100725784  DT.100725828  DT.100725762  DT.92032774  DT.91645718  DT.100725796  DT.95264225 
    DT.85105360  DT.100725748  DT.100859202  DT.100725751  DT.91698577  DT.92472227  DT.100046018  DT.100847445 
    DT.100725794  DT.91898151  DT.100725817  DT.100045999  DT.100725742  DT.92002214  DT.100837162  DT.100725785 

    24/3156 AceView cDNA sequences (see all 3156):

    BC073162 AW327336 BX365979 AI339467 BE795278 BU849444 AI523072 BM850174 
    BX421174 AI357369 AL538842 BU182999 BQ216357 CD677644 CR625490 BM463640 
    BQ675854 CB135953 BU187282 AA342367 AA312491 BM828905 AI189865 CA432992 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                -     -     -                                                                                 
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for HNRNPA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNRNPA1 expression in normal human tissues (normalized intensities)      HNRNPA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTTGATTG
    HNRNPA1 Expression
    About this image


    HNRNPA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/37 selected tissues (see all 37) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             Human Cerebellar Astrocytes   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See HNRNPA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNRNPA1

    SOURCE GeneReport for Unigene cluster: Hs.546261
        SABiosciences Custom PCR Arrays for HNRNPA1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HNRNPA1
    OriGene qSTAR qPCR primer pairs in human, mouse for HNRNPA1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HNRNPA1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HNRNPA1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRNPA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HNRNPA1 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnrnpa11 , 5 heterogeneous nuclear ribonucleoprotein A11, 5 93.55(n)1
    99.73(a)1
      15 (58.58 cM)5
    153821  NM_001039129.31  NP_001034218.11 
     1032404325 
    chicken
    (Gallus gallus)
    Aves HNRNPA31 heterogeneous nuclear ribonucleoprotein A3 78.1(n)
    94.19(a)
      424136  NM_001031253.1  NP_001026424.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    84(a)
    1 → many
    2(71258665-71268894)
    African clawed frog
    (Xenopus laevis)
    Amphibia hnrpa1-prov2 heterogeneous ribonuclear particle protein 77.67(n)    BC045260.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.7082 Danio rerio mRNA similar to heterogeneous nuclear ribonucleoprotein more 78.42(n)    BC044442.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hrb87F1 Heterogeneous nuclear ribonucleoprotein at 87F 55.14(n)
    54.18(a)
      48535  NM_057459.4  NP_476807.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g02215001 hypothetical protein 52.37(n)
    46.45(a)
      4328758  NM_001052857.1  NP_001046322.1 


    ENSEMBL Gene Tree for HNRNPA1 (if available)
    TreeFam Gene Tree for HNRNPA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HNRNPA1 gene
    HNRNPDL2  HNRNPD2  HNRNPA02  HNRNPA32  HNRNPAB2  DAZAP12  HNRNPA1L22  HNRNPA2B12  
    18/44 SIMAP similar genes for HNRNPA1 using alignment to 7 protein entries:     ROA1_HUMAN (see all proteins) (see all similar genes):
    HNRPA1    D10S102    HNRNPA2B1    HNRNPA1L2    HNRNPA3    HNRPA3
    BOLL    RBMXL3    HNRNPA0    CIRBP    HNRNPD    HNRNPAB
    RBMXL2    RBMX    MSI2    HNRPDL    ELAVL1    PABPC4

    HNRNPA1 for paralogs           About GeneDecksing


    5/85 Pseudogenes.org Pseudogenes for HNRNPA1 (see all 85)
    PGOHUM00000261082 PGOHUM00000261085 PGOHUM00000261086 PGOHUM00000261104 PGOHUM00000261106


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/105 SNPs in HNRNPA1 are shown (see all 105)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0147114
    ----see VAR_0147112 N S mis40--------
    rs1145817981,2
    C,F--54676109(+) ATTTAG/TTAAGG 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1828669321,2
    C--54676114(+) GTAAGG/TGTTCC 2 -- int10--------
    rs2021190451,2
    C--54676165(+) TTTTT-/TAGTTC 2 -- int10--------
    rs2006430191,2
    --54676218(+) GAAGTG/TAGAAA 4 V syn10--------
    rs1997634501,2
    --54676230(+) GCCCTC/GTCAAA 4 L syn10--------
    rs2007079181,2
    C,F--54676233(+) CTGTCA/GAAGCA 4 S syn11Minor allele frequency- G:0.00EU 1323
    rs780023761,2
    C--54676311(+) TTTGAG/TTTACT 2 -- int10--------
    rs2013870661,2
    --54676321(+) TCCAGC/TATGAA 2 -- int10--------
    rs1883666121,2
    C--54676338(+) AATGCC/TTAAAC 2 -- int10--------

    HapMap Linkage Disequilibrium report for HNRNPA1 (54673977 - 54680872 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HNRNPA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv25123CNV Loss19812545
    nsv832420CNV Loss17160897


    Human Gene Mutation Database (HGMD): HNRNPA1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HNRNPA1
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRNPA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164017    OMIM disorders: --

    20/36 diseases for HNRNPA1 (see all 36):    About MalaCards
    human t-cell leukemia virus type 2    oculopharyngeal muscular dystrophy    spinal cord disease    spinal muscular atrophy
    tropical spastic paraparesis    spastic paraparesis    neurologic diseases    stomatitis
    t-cell leukemia    human t-cell leukemia virus type 1    muscular atrophy    spasticity
    burkitt's lymphoma    colon adenocarcinoma    muscular dystrophy    cytochrome p450
    acute leukemia    cystic fibrosis    colorectal cancer    crohn's disease

    2 diseases from the University of Copenhagen DISEASES database for HNRNPA1:
    Tropical spastic paraparesis     Spinal cord disease

    HNRNPA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for HNRNPA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 37.6 2 11893730 (1), 7474099 (1)
    mimicry 25.7 2 12707436 (1), 16600502 (1)
    immunodeficiency 21.2 2 19737937 (1), 19625255 (1)
    colorectal cancer 8.21 1 19715280 (1)
    tumors 0 1 9865741 (1)
    prostate cancer 0 1 17110431 (1)
    cancer 0 1 20010808 (1)

    Genetic Association Database (GAD): HNRNPA1
    Human Genome Epidemiology (HuGE) Navigator: HNRNPA1 (3 documents)

    Export disorders for HNRNPA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNRNPA1 gene, integrated from 9 sources (see all 278):
    (articles sorted by number of sources associating them with HNRNPA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human heterogeneous nuclear ribonucleoprotein A1 gene (HNRPA1) to chromosome 12q13.1 by cDNA competitive in situ hybridization. (PubMed id 1733858)1, 3, 9 Saccone S....Della Valle G. (1992)
    2. Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein. (PubMed id 1691095)1, 2, 9 Buvoli M.... Riva S. (1990)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. (PubMed id 17229681)1, 2 Kim C.S....Jang S.K. (2007)
    5. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. (PubMed id 15161980)1, 2 Li T....Chock P.B. (2004)
    8. Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)1, 2 Ong S.E.... Mann M. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3178 HGNC: 5031 AceView: HNRPA1 Ensembl:ENSG00000135486 euGenes: HUgn3178
    ECgene: HNRNPA1 Kegg: 3178 H-InvDB: HNRNPA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNRNPA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HNRNPA1 gene:
    Search GeneIP for patents involving HNRNPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HNRNPA1
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HNRNPA1  
     OriGene qPCR primer pairs and template standards for HNRNPA1   OriGene Protein Over-expression Lysate for HNRNPA1  
     OriGene MassSpec something-or-other for HNRNPA1   OriGene clones in human, mouse for HNRNPA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for HNRNPA1   OriGene Purified Protein for HNRNPA1  
     OriGene ORF clones in mouse, rat for HNRNPA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HNRNPA1   OriGene Custom Protein Services for HNRNPA1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HNRNPA1
     QIAGEN SeqTarget long-range PCR primers for resequencing HNRNPA1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPA1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HNRNPA1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRNPA1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HNRNPA1
     GenScript Custom Purified and Recombinant Proteins Services for HNRNPA1 GenScript cDNA clones with any tag delivered in your preferred vector for HNRNPA1
     GenScript Custom Assay Services for HNRNPA1 GenScript Custom Superior Antibodies Services for HNRNPA1
     GenScript Custom overexpressing Cell Line Services for HNRNPA1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for HNRNPA1 
    (hnRNP A1)

     Regulatory tfbs in HNRNPA1 promoter
     Search Chromatin IP Primers for HNRNPA1
     RT2 qPCR Primer Assay in human, mouse, rat HNRNPA1
     GNC Network for HNRNPA1
     SABiosciences Custom PCR Arrays for HNRNPA1
     Search Tocris compounds for HNRNPA1 (ROA1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HNRNPA1 antibodies
     HNRNPA1 proteins
     HNRNPA1 lysates
     Antibodies for HNRNPA1
     See all of Abcam's Antibodies, Kits and Proteins for HNRNPA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HNRNPA1




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for HNRNPA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRNPA1
     SwitchGear 3'UTR luciferase reporter plasmids for HNRNPA1
     SwitchGear Promoter luciferase reporter plasmids for HNRNPA1
     ThermoFisher Antibody for HNRNPA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRNPA1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HNRNPA1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HNRNPA1
    Customized:
     lentivirus for stable overexpression of HNRNPA1
     lentivirus expression plasmids for stable overexpression of HNRNPA1
     adenovirus for overexpression of HNRNPA1
     LSBio Antibodies in human, mouse, rat for HNRNPA1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HNRNPA1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4