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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNRNPA1 Gene

protein-coding   GIFtS: 61
GCID: GC12P054674

heterogeneous nuclear ribonucleoprotein A1


(Previous symbol: HNRPA1)
 Explore 39 diseases affiliated with
HNRNPA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HNRNPA1    

Aliases
for HNRNPA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heterogeneous Nuclear Ribonucleoprotein A11 2     Heterogeneous Nuclear Ribonucleoprotein A1B Protein2
HNRPA11 2 3 5     Heterogeneous Nuclear Ribonucleoprotein B2 Protein2
HnRNP-A11     Heterogeneous Nuclear Ribonucleoprotein Core Protein A12
Helix-Destabilizing Protein2 3     HnRNP A1-Like 32
Single-Strand RNA-Binding Protein2 3     HnRNP Core Protein A1-Like 32
HnRNP A12 3     Nuclear Ribonucleoprotein Particle A1 Protein2
HnRNP Core Protein A12 3     Putative Heterogeneous Nuclear Ribonucleoprotein A1-Like 32
HnRNPA11     Single-Strand DNA-Binding Protein UP12
HNRPA1L32     

External Ids:    HGNC: 50311   Entrez Gene: 31782   Ensembl: ENSG000001354867   OMIM: 1640175   UniProtKB: P096513   

Export aliases for HNRNPA1 gene to outside databases

Previous GC identifers: GC12P052961 GC12P051713


Summaries
for HNRNPA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HNRNPA1:
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated
with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and
transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the
cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two
repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it
is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably
bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export
signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA
from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in
the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript
variants have been found for this gene but only two transcripts are fully described. These variants have multiple
alternative transcription initiation sites and multiple polyA sites. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ROA1_HUMAN, P09651
Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the
cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication

Gene Wiki entry for HNRNPA1 (Heterogeneous nuclear ribonucleoprotein A1)


Genomic Views
for HNRNPA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNRNPA1 gene promoter:
         AML1a   E2F-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HNRNPA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HNRNPA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRNPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.1   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.1

HNRNPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRNPA1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054674:  view genomic region     (about GC identifiers)

Start:
 54,673,977 bp from pter      End:
 54,680,872 bp from pter
Size:
 6,896 bases      Orientation:
 plus strand

Proteins
for HNRNPA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ROA1_HUMAN, P09651 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein A1  
Size: 372 amino acids; 38747 Da
Subunit: Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB,
ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3,
NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated
mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA
Subcellular location: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. In the
course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent
manner
6/16 PDB 3D structures from and Proteopedia for HNRNPA1 (see all 16):
1HA1 (3D)        1L3K (3D)        1PGZ (3D)        1PO6 (3D)        1U1K (3D)        1U1L (3D)    
Secondary accessions: A8K4Z8 Q3MIB7 Q6PJZ7
Alternative splicing: 3 isoforms:  P09651-1   P09651-2   P09651-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HNRNPA1: NX_P09651

Post-translational modifications:

  • Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine1
  • Sumoylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09651

    • HNRNPA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_002127.1  NP_112420.1  

    ENSEMBL proteins: 
     ENSP00000448617   ENSP00000448229   ENSP00000449913   ENSP00000448795   ENSP00000448201  
     ENSP00000341826   ENSP00000333504   ENSP00000447439   ENSP00000448117   ENSP00000391986  
     ENSP00000448633   ENSP00000447260   ENSP00000447782   ENSP00000448917   ENSP00000446486  
    Reactome Protein details: P09651
    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for HNRNPA1
    Uscn Proteins for HNRNPA1

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    HNRNPA1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HNRNPA1

    Protein Domains /
    Families
    for HNRNPA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HNRNPA1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P09651

    ProtoNet protein and cluster: P09651

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: ROA1_HUMAN, P09651
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Function
    for HNRNPA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ROA1_HUMAN, P09651
    Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the
    cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003697single-stranded DNA binding IDA8521471
    GO:0003723RNA binding TAS8521471
    GO:0003727single-stranded RNA binding IC8521471


    HNRNPA1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for HNRNPA1:
     Increased HPV18 LCR reporter a  Low eccentricity cells 


    Pathways & Interactions
    for HNRNPA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA Splicing - Major Pathway1.00
    		mRNA Processing0.82
    		mRNA Splicing1.00
    		mRNA processing0.48
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    		Spliceosome0.31
    2Coregulation of Androgen receptor activity
    		Coregulation of Androgen receptor activity1.00
    3Translational Control
    		Translational Control1.00
    4Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HNRNPA1
        Translational Control

    2 BioSystems Pathways for HNRNPA1 
        mRNA processing
    Coregulation of Androgen receptor activity

    5        Reactome Pathways for HNRNPA1
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA


    1         Kegg Pathway  (Kegg details for HNRNPA1):
        Spliceosome


    HNRNPA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HNRNPA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/837 Interacting proteins for HNRNPA1 (P096512, 3 ENSP000003418264) via UniProtKB, MINT, STRING, and/or I2D (see all 837)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX5P178442, 3, ENSP000002257924MINT-7945693 MINT-6167588 MINT-6167618 MINT-8395092 I2D: score=1 STRING: ENSP00000225792
    ABHD16AO958702, 3, ENSP000003792824MINT-62698 MINT-62774 MINT-62600 I2D: score=3 STRING: ENSP00000379282
    ILF3Q129062, 3, ENSP000004041214MINT-7945693 MINT-6167588 MINT-6167618 I2D: score=1 STRING: ENSP00000404121
    HNRNPCP079102, 3, ENSP000003196904MINT-7945693 MINT-7234902 I2D: score=2 STRING: ENSP00000319690
    DDX17Q928412, 3, ENSP000003800334MINT-7945693 MINT-8395092 I2D: score=1 STRING: ENSP00000380033
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000380alternative mRNA splicing, via spliceosome ----
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing TAS8521471
    GO:0006405RNA export from nucleus IC8521471
    GO:0008380RNA splicing TAS--


    HNRNPA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HNRNPA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HNRNPA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HNRNPA1
    1 Novoseek chemical compound relationship for HNRNPA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 1 1656054 (1)

    Search CenterWatch for drugs/clinical trials and news about HNRNPA1 / ROA1 

    Transcripts
    for HNRNPA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HNRNPA1 gene (2 alternative transcripts): 
    NM_002136.2  NM_031157.2  

    Unigene Cluster for HNRNPA1:

    Heterogeneous nuclear ribonucleoprotein A1
    Hs.546261  [show with all ESTs]
    Unigene Representative Sequence: NM_031157
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000546500(uc001sfm.3 uc001sfn.3 uc001sfo.3) ENST00000547708
    ENST00000547566 ENST00000547870 ENST00000547617 ENST00000552494 ENST00000340913(uc001sfl.3 uc009znj.1)
    ENST00000330752 ENST00000552591 ENST00000551702 ENST00000420780 ENST00000551133
    ENST00000548704 ENST00000547276 ENST00000548688 ENST00000550994 ENST00000550482
    ENST00000551679

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    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRNPA1 (see all 52):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-300 hsa-miR-330-5p hsa-miR-411 hsa-miR-15a hsa-miR-503 hsa-miR-218
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK129814.1 AK291113.1 AK298176.1 AK303303.1 AK308679.1 BC002355.2 BC004945.1 BC009600.1 
    BC012158.1 BC020442.2 BC033714.1 BC035253.1 BC052296.1 BC070315.1 BC071945.1 BC073162.1 
    BC074502.1 BC078165.1 BC103707.1 BC104236.1 BC104237.1 BC121133.2 U00947.1 X04347.1 
    X06747.1 X79536.1 

    24/171 DOTS entries (see all 171):

    DT.95264221  DT.100725784  DT.100725828  DT.100725762  DT.92032774  DT.91645718  DT.100725796  DT.95264225 
    DT.85105360  DT.100725748  DT.100859202  DT.100725751  DT.91698577  DT.92472227  DT.100046018  DT.100847445 
    DT.100725794  DT.91898151  DT.100725817  DT.100045999  DT.100725742  DT.92002214  DT.100837162  DT.100725785 

    24/3156 AceView cDNA sequences (see all 3156):

    BQ422343 CR600495 D57461 BQ434600 CR614407 BE895301 BE784620 BX443764 
    BX441250 CR622095 AA315513 CR597174 BM850174 AU145567 BM840125 BG057329 
    CR618772 BM771649 AW611574 CR598845 CB045524 BE890155 BC052296 BM553186 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                -     -     -                                                                                 
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for HNRNPA1

    Expression
    for HNRNPA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNRNPA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGTTGATTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HNRNPA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HNRNPA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNRNPA1

    SOURCE GeneReport for Unigene cluster: Hs.546261
        SABiosciences Custom PCR Arrays for HNRNPA1
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    In Situ
    Assay Products:     
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    Orthologs
    for HNRNPA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HNRNPA1 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HNRNPA31 heterogeneous nuclear ribonucleoprotein A3 78.1(n)
    94.19(a)    		   424136  NM_001031253.1  NP_001026424.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 83(a)
    		 1 → many
    		 2(71261098-71268827)
    African clawed frog
    (Xenopus laevis)    		 Amphibia hnrpa1-prov2 heterogeneous ribonuclear particle protein 77.67(n)    BC045260.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.7082 Danio rerio mRNA similar to heterogeneous nuclear ribonucleoprotein more 78.42(n)    BC044442.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hrb87F1 Heterogeneous nuclear ribonucleoprotein at 87F 55.14(n)
    54.18(a)    		   48535  NM_057459.4  NP_476807.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea hrp-16
    		 Heterogeneous nuclear ribonucleoprotein A1
    		 35(a)
    		 1 → many
    		 IV(3336921-3338864)
    rice
    (Oryza sativa)    		 Liliopsida Os02g02215001 hypothetical protein 52.37(n)
    46.45(a)    		   4328758  NM_001052857.1  NP_001046322.1 


    ENSEMBL Gene Tree for HNRNPA1 (if available)
    TreeFam Gene Tree for HNRNPA1 (if available) 

    Paralogs
    for HNRNPA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HNRNPA1 gene
    HNRNPA32  DAZAP12  HNRNPA2B12  HNRNPA1L22  MSI12  HNRNPD2  MSI22  HNRNPA02  
    HNRNPAB2  HNRPDL2  
    18/77 SIMAP similar genes for HNRNPA1 using alignment to 12 protein entries:     ROA1_HUMAN (see all proteins) (see all similar genes):
    HNRPA1    HNRNPA1L2    D10S102    HNRNPA2B1    HNRNPA3    HNRPA3
    BOLL    CELF4    HNRNPA0    CIRBP    CELF3    CELF5
    TNRC4    RBMXL3    RBMXL2    RBMX    RBMY1C    RBMY1D

    HNRNPA1 for paralogs           About GeneDecksing


    5/85 Pseudogenes.org Pseudogenes for HNRNPA1 (see all 85)
    PGOHUM00000261082 PGOHUM00000261085 PGOHUM00000261086 PGOHUM00000261104 PGOHUM00000261106


    Genomic Variants
    for HNRNPA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/131 NCBI SNPs in HNRNPA1 are shown (see all 131)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs733045041,2
    		C,--54672744(+) AAAGGG/AGTTGT 3 -- int1 us2k11Minor allele frequency- A:0.50WA 2
    rs1875739281,2
    		--54672870(+) TCCTAC/TTGTGT 3 -- us2k1 int10--------
    rs767534791,2
    		C,F,--54672890(+) TGACAC/TTNNNN 3 -- int1 us2k11Minor allele frequency- T:0.03NA 120
    rs1503293041,2
    		--54672985(+) GAACGC/TCTTTC 3 -- us2k1 int10--------
    rs1464434281,2
    		--54673040(+) ACAGTC/TTTCCT 3 -- us2k1 int10--------
    rs1454589011,2
    		C,--54673076(+) TTTAA-/AAAC  
                AAACA     		3 -- int1 us2k10--------
    rs2018830411,2
    		--54673085(+) AAACA-/AACAAAAA 3 -- int1 us2k10--------
    rs2009043021,2
    		--54673087(+) CAAAC-/AAAAAA 3 -- us2k1 int10--------
    rs1178611121,2
    		F,--54673221(+) CGTTAG/AAGAAG 3 -- us2k1 int11Minor allele frequency- A:0.03EA 120
    rs284971621,2
    		C--54673246(+) ACATCC/GACCCT 3 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for HNRNPA1 (54673977 - 54680872 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HNRNPA1
         1 CNV: 66229

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    Disorders / Diseases
    for HNRNPA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HNRNPA1 for disorders           About GeneDecksing

    OMIM gene information: 164017    OMIM disorders: --

    20/39 diseases for HNRNPA1 (see all 39):    About MalaCards
    human t-cell leukemia virus type 2    human t-cell leukemia virus type 1    spinal cord disease    tropical spastic paraparesis
    oculopharyngeal muscular dystrophy    treacher collins syndrome    spastic paraparesis    muscular dystrophy
    metastasis efficiency    muscular atrophy    burkitt's lymphoma    t-cell leukemia
    cystic fibrosis    neurologic diseases    hepatitis c    stomatitis
    colorectal cancer    crohn's disease    leukemia    colon adenocarcinoma

    3 diseases from the University of Copenhagen DISEASES database for HNRNPA1:
    Spinal muscular atrophy     Tropical spastic paraparesis     Spinal cord disease

    7 Novoseek disease relationships for HNRNPA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 37.6 2 11893730 (1), 7474099 (1)
    mimicry 25.7 2 12707436 (1), 16600502 (1)
    immunodeficiency 21.2 2 19737937 (1), 19625255 (1)
    colorectal cancer 8.21 1 19715280 (1)
    tumors 0 1 9865741 (1)
    prostate cancer 0 1 17110431 (1)
    cancer 0 1 20010808 (1)

    Human Genome Epidemiology (HuGE) Navigator: HNRNPA1 (3 documents)

    Export disorders for HNRNPA1 gene to outside databases

    Publications
    for HNRNPA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNRNPA1 gene, integrated from 9 sources (see all 250):
    (articles sorted by number of sources associating them with HNRNPA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human heterogeneous nuclear ribonucleoprotein A1 gene (HNRPA1) to chromosome 12q13.1 by cDNA competitive in situ hybridization. (PubMed id 1733858)1, 3, 9 Saccone S....Della Valle G. (1992)
    2. Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein. (PubMed id 1691095)1, 2, 9 Buvoli M.... Riva S. (1990)
    3. An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. (PubMed id 17229681)1, 2 Kim C.S....Jang S.K. (2007)
    4. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. (PubMed id 15161980)1, 2 Li T....Chock P.B. (2004)
    7. Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)1, 2 Ong S.E.... Mann M. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    10. Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. (PubMed id 9115444)1, 2 Xu R.M.... Krainer A.R. (1997)

    External Searches for HNRNPA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HNRNPA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3178 HGNC: 5031 AceView: HNRPA1 Ensembl:ENSG00000135486 euGenes: HUgn3178
    ECgene: HNRNPA1 Kegg: 3178 H-InvDB: HNRNPA1

    Other Databases showing HNRNPA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HNRNPA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNRNPA1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HNRNPA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HNRNPA1 gene:
    Search GeneIP for patents involving HNRNPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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