Aliases for HNRNPA1 Gene
Aliases for HNRNPA1 Gene
- Heterogeneous Nuclear Ribonucleoprotein A1 2 3 5
- Single-Strand RNA-Binding Protein 3 4
- Helix-Destabilizing Protein 3 4
- HnRNP A1 3 4
- HNRPA1 3 4
- Putative Heterogeneous Nuclear Ribonucleoprotein A1-Like 3 3
- Heterogeneous Nuclear Ribonucleoprotein Core Protein A1 3
- Heterogeneous Nuclear Ribonucleoprotein A1B Protein 3
- Heterogeneous Nuclear Ribonucleoprotein B2 Protein 3
- Nuclear Ribonucleoprotein Particle A1 Protein 3
External Ids for HNRNPA1 Gene
- HGNC: 5031
- Entrez Gene: 3178
- Ensembl: ENSG00000135486
- OMIM: 164017
- UniProtKB: P09651
Previous HGNC Symbols for HNRNPA1 Gene
- HNRPA1
Previous GeneCards Identifiers for HNRNPA1 Gene
- GC12P052961
- GC12P054674
- GC12P051713
Summaries for HNRNPA1 Gene
-
This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016]
GeneCards Summary for HNRNPA1 Gene
HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) is a Protein Coding gene. Diseases associated with HNRNPA1 include Inclusion Body Myopathy Wtih Early-Onset Paget Disease Without Frontotemporal Dementia 3 and Amyotrophic Lateral Sclerosis 20. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPA1L2.
UniProtKB/Swiss-Prot for HNRNPA1 Gene
-
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.
-
(Microbial infection) May play a role in HCV RNA replication.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA1 Gene
Genomics for HNRNPA1 Gene
Regulatory Elements for HNRNPA1 Gene
Enhancers for HNRNPA1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HNRNPA1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HNRNPA1 gene promoter:
Regulatory Element Products
Genomic Location for HNRNPA1 Gene
- Chromosome:
- 12
- Start:
- 54,280,193 bp from pter
- End:
- 54,287,088 bp from pter
- Size:
- 6,896 bases
- Orientation:
- Plus strand
Genomic View for HNRNPA1 Gene
Genes around HNRNPA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Ensembl
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
HNRNPA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPA1 Gene
Proteins for HNRNPA1 Gene
-
Protein details for HNRNPA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09651-ROA1_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoprotein A1
- Protein Accession:
- P09651
- A8K4Z8
- Q3MIB7
- Q6PJZ7
Protein attributes for HNRNPA1 Gene
- Size:
- 372 amino acids
- Molecular mass:
- 38747 Da
- Quaternary structure:
-
- Identified in the spliceosome C complex (PubMed:11991638). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with SEPT6 (PubMed:17229681). Interacts with C9orf72 (PubMed:24549040). Interacts with KHDRBS1 (PubMed:17371836). Interacts with UBQLN2 (PubMed:25616961).
- (Microbial infection) Interacts with HCV NS5B and with the 5-UTR and 3-UTR of HCV RNA.
Three dimensional structures from OCA and Proteopedia for HNRNPA1 Gene
Protein Expression for HNRNPA1 Gene
Post-translational modifications for HNRNPA1 Gene
- Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine.
- Sumoylated.
- Ubiquitination at isoforms=3, 278 and posLast=350350
- Modification sites at PhosphoSitePlus
Other Protein References for HNRNPA1 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HNRNPA1
- Cell Signaling Technology (CST) Antibodies for HNRNPA1 (hnRNP A1)
-
Custom Antibody ServicesOriGene Antibodies for HNRNPA1
- Novus Biologicals Antibodies for HNRNPA1
-
Abcam antibodies for HNRNPA1
-
Cloud-Clone Corp. Antibodies for HNRNPA1
- Invitrogen Antibodies for HNRNPA1
- antibodies-online Antibodies for HNRNPA1: See all 94
- GeneTex HNRNPA1 antibody for HNRNPA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPA1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HNRNPA1
- Origene Custom Protein Services for HNRNPA1
- ProSpec Recombinant Proteins for HNRNPA1
-
Cloud-Clone Corp. Proteins for HNRNPA1
- antibodies-online Proteins for HNRNPA1: See all 13
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HNRNPA1
-
Abcam proteins for HNRNPA1
Assay Products
- antibodies-online Kits for HNRNPA1: See all 26
No data available for DME Specific Peptides for HNRNPA1 Gene
Domains & Families for HNRNPA1 Gene
Gene Families for HNRNPA1 Gene
Protein Domains for HNRNPA1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HNRNPA1 Gene
Function for HNRNPA1 Gene
Molecular function for HNRNPA1 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) May play a role in HCV RNA replication.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003697 | single-stranded DNA binding | IDA | 8521471 |
| GO:0003723 | RNA binding | IDA,TAS | 22658674 |
| GO:0003727 | single-stranded RNA binding | IC | 8521471 |
| GO:0005515 | protein binding | IPI | 17229681 |
Phenotypes for HNRNPA1 Gene
- GenomeRNAi human phenotypes for HNRNPA1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA1 gene
- Search ViGene Biosciences for HNRNPA1
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPA1
- GenScript: Design CRISPR guide RNA sequences for HNRNPA1
miRNA for HNRNPA1 Gene
- miRTarBase miRNAs that target HNRNPA1
-
- hsa-mir-1-3p (MIRT024037)
- hsa-mir-30a-5p (MIRT028678)
- hsa-mir-19b-3p (MIRT031226)
- hsa-mir-1296-5p (MIRT036122)
- hsa-mir-1229-3p (MIRT036356)
- hsa-mir-22-5p (MIRT038961)
- hsa-mir-615-3p (MIRT039996)
- hsa-mir-484 (MIRT042186)
- hsa-mir-339-5p (MIRT042762)
- hsa-mir-324-5p (MIRT043217)
- hsa-mir-194-5p (MIRT044875)
- hsa-mir-186-5p (MIRT045060)
- hsa-mir-197-3p (MIRT048099)
- hsa-mir-96-5p (MIRT048737)
- hsa-mir-25-3p (MIRT050353)
- hsa-mir-1260b (MIRT052722)
- hsa-mir-466 (MIRT113392)
- hsa-mir-4643 (MIRT113395)
- hsa-mir-5585-5p (MIRT493580)
- hsa-mir-4284 (MIRT493581)
- hsa-mir-6837-3p (MIRT493582)
- hsa-mir-6754-3p (MIRT493583)
- hsa-mir-412-3p (MIRT493584)
- hsa-mir-4330 (MIRT493585)
- hsa-mir-5693 (MIRT493586)
- hsa-mir-577 (MIRT493587)
- hsa-mir-548m (MIRT493588)
- hsa-mir-24-3p (MIRT493589)
- hsa-mir-513b-5p (MIRT502269)
- hsa-mir-125b-2-3p (MIRT502270)
- hsa-mir-4457 (MIRT502271)
- hsa-mir-4452 (MIRT536799)
- hsa-mir-8070 (MIRT536800)
- hsa-mir-183-3p (MIRT536801)
- hsa-mir-203b-3p (MIRT536802)
- hsa-mir-7158-3p (MIRT536803)
- hsa-mir-3689f (MIRT536804)
- hsa-mir-3689e (MIRT536805)
- hsa-mir-3689b-5p (MIRT536806)
- hsa-mir-3689a-5p (MIRT536807)
- hsa-mir-219a-2-3p (MIRT536808)
- hsa-mir-219b-3p (MIRT536809)
- hsa-mir-8073 (MIRT536810)
- hsa-mir-6868-5p (MIRT536811)
- hsa-mir-221-5p (MIRT536812)
- hsa-mir-1179 (MIRT536813)
- hsa-mir-6505-5p (MIRT557230)
- hsa-mir-323a-3p (MIRT557231)
- hsa-mir-548ay-3p (MIRT557232)
- hsa-mir-548at-3p (MIRT557233)
- hsa-mir-548as-3p (MIRT557234)
- hsa-mir-548t-3p (MIRT557235)
- hsa-mir-548ap-3p (MIRT557236)
- hsa-mir-548aa (MIRT557237)
- hsa-mir-206 (MIRT557238)
- hsa-mir-613 (MIRT557239)
- hsa-mir-4444 (MIRT574693)
- hsa-mir-4641 (MIRT574694)
- hsa-mir-1910-5p (MIRT574695)
- hsa-mir-4789-3p (MIRT574696)
- hsa-mir-129-5p (MIRT574697)
- hsa-mir-496 (MIRT574698)
- hsa-mir-4477a (MIRT623684)
- hsa-mir-660-5p (MIRT623685)
- hsa-mir-1273d (MIRT623686)
- hsa-mir-548z (MIRT623687)
- hsa-mir-548h-3p (MIRT623688)
- hsa-mir-548d-3p (MIRT623689)
- hsa-mir-548bb-3p (MIRT623690)
- hsa-mir-548ac (MIRT623691)
- hsa-mir-3169 (MIRT702841)
- hsa-mir-2113 (MIRT702842)
- hsa-mir-3674 (MIRT702843)
- hsa-mir-6842-3p (MIRT702844)
- hsa-mir-647 (MIRT702845)
- hsa-mir-4715-3p (MIRT702846)
- hsa-mir-6844 (MIRT702847)
- hsa-mir-4524b-5p (MIRT702848)
- hsa-mir-4524a-5p (MIRT702849)
- hsa-mir-3613-5p (MIRT702850)
- hsa-mir-636 (MIRT702851)
- hsa-mir-6775-3p (MIRT702852)
- hsa-mir-1291 (MIRT702853)
- hsa-mir-8077 (MIRT702854)
- hsa-mir-6799-3p (MIRT702855)
- hsa-mir-3173-5p (MIRT702856)
- hsa-mir-4778-3p (MIRT702857)
- hsa-mir-367-5p (MIRT702858)
- hsa-mir-1267 (MIRT702859)
- hsa-mir-7157-3p (MIRT702860)
- hsa-mir-6737-3p (MIRT702861)
- hsa-mir-5008-3p (MIRT702862)
- hsa-mir-3137 (MIRT702863)
- hsa-mir-4682 (MIRT702864)
- hsa-mir-6727-3p (MIRT702865)
- hsa-mir-4722-3p (MIRT702866)
- hsa-mir-6752-3p (MIRT702867)
- hsa-mir-4719 (MIRT702868)
- hsa-mir-4762-5p (MIRT702869)
- hsa-mir-4747-3p (MIRT702870)
- hsa-mir-646 (MIRT702871)
- hsa-mir-649 (MIRT702872)
- hsa-mir-6838-5p (MIRT702873)
- hsa-mir-195-5p (MIRT702874)
- hsa-mir-16-5p (MIRT702875)
- hsa-mir-15b-5p (MIRT702876)
- hsa-mir-424-5p (MIRT702877)
- hsa-mir-503-5p (MIRT702878)
- hsa-mir-15a-5p (MIRT702879)
- hsa-mir-497-5p (MIRT702880)
- hsa-mir-218-5p (MIRT702881)
- hsa-mir-8057 (MIRT702882)
- hsa-mir-3191-5p (MIRT702883)
- hsa-mir-4279 (MIRT702884)
- hsa-mir-7111-3p (MIRT702885)
- hsa-mir-670-5p (MIRT702886)
- hsa-mir-6822-3p (MIRT702887)
- hsa-mir-942-5p (MIRT702888)
- hsa-mir-6773-3p (MIRT702889)
- hsa-mir-664a-5p (MIRT702890)
- hsa-mir-4794 (MIRT702891)
- hsa-mir-6824-3p (MIRT702892)
- hsa-mir-6764-3p (MIRT702893)
- hsa-mir-518c-5p (MIRT702894)
- hsa-mir-6845-3p (MIRT702895)
- hsa-mir-1976 (MIRT702896)
- hsa-mir-3653-5p (MIRT702897)
- hsa-mir-6769b-3p (MIRT702898)
- hsa-mir-4723-3p (MIRT702899)
- hsa-mir-3183 (MIRT702900)
- hsa-mir-668-3p (MIRT702901)
- hsa-mir-330-5p (MIRT702902)
- hsa-mir-326 (MIRT702903)
- hsa-mir-3064-5p (MIRT702904)
- hsa-mir-6504-5p (MIRT702905)
- hsa-mir-149-5p (MIRT702906)
- hsa-mir-760 (MIRT702907)
- hsa-mir-370-3p (MIRT702908)
- hsa-mir-6893-3p (MIRT702909)
miRNA Products
- Search ViGene Biosciences for HNRNPA1
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for HNRNPA1
- Browse OriGene Inhibitory RNA Products For HNRNPA1
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA1 gene
Clone Products
- Sino Biological Human cDNA Clone for HNRNPA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HNRNPA1
Cell Line Products
-
Horizon Cell Lines for HNRNPA1
-
ViGene Biosciences adenoviral particle packaged cDNA for HNRNPA1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA1 Gene
Localization for HNRNPA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA1 Gene
- Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes (PubMed:17289661). {ECO:0000269 PubMed:17289661, ECO:0000269 PubMed:27694260}.
- Cytoplasm. Note=(Microbial infection) In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner. {ECO:0000269 PubMed:17229681}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 23935072 |
| GO:0005654 | nucleoplasm | TAS,IDA | -- |
| GO:0005681 | spliceosomal complex | IDA | 9731529 |
| GO:0005737 | cytoplasm | IDA | 8521471 |
| GO:0016020 | membrane | IDA | 19946888 |
Pathways & Interactions for HNRNPA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.50
.41
|
| 2 | Signaling by FGFR2 | ||
| 3 | Translational Control | ||
| 4 | Telomere Extension by Telomerase | ||
| 5 | mRNA Capping | ||
Pathways by source for HNRNPA1 Gene
1 Cell Signaling Technology pathway for HNRNPA1 Gene
2 BioSystems pathways for HNRNPA1 Gene
8 Reactome pathways for HNRNPA1 Gene
1 KEGG pathway for HNRNPA1 Gene
1 Qiagen pathway for HNRNPA1 Gene
Interacting Proteins for HNRNPA1 Gene
Selected Interacting proteins:
ENSP00000341826
P09651-ROA1_HUMAN
for HNRNPA1 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | IMP | 25689357 |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006397 | mRNA processing | TAS | 8521471 |
| GO:0006405 | RNA export from nucleus | IC | 8521471 |
| GO:0006810 | transport | IEA | -- |
Transcripts for HNRNPA1 Gene
mRNA/cDNA for HNRNPA1 Gene
- (4) REFSEQ mRNAs :
- (26) Additional mRNA sequences :
- (3156) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HNRNPA1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPA1
- GenScript: Design CRISPR guide RNA sequences for HNRNPA1
miRNA Products
- Search ViGene Biosciences for HNRNPA1
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for HNRNPA1
- Browse OriGene Inhibitory RNA Products For HNRNPA1
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA1 gene
Clone Products
- Sino Biological Human cDNA Clone for HNRNPA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HNRNPA1
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - |
Expression for HNRNPA1 Gene
This gene is overexpressed in Fetal gut (6.7) and Fetal ovary (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPA1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HNRNPA1 Gene:
HNRNPA1SOURCE GeneReport for Unigene cluster for HNRNPA1 Gene:
Hs.546261Evidence on tissue expression from TISSUES for HNRNPA1 Gene
- Nervous system(5)
- Eye(4.9)
- Kidney(4.9)
- Liver(4.9)
- Lung(4.9)
- Blood(4.8)
- Intestine(4.7)
- Skin(4.2)
- Bone marrow(4)
- Pancreas(4)
- Muscle(3.9)
- Heart(3.6)
- Stomach(3.5)
- Bone(3)
- Spleen(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPA1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- nervous
- respiratory
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- epiglottis
- face
- head
- jaw
- larynx
- mandible
- maxilla
- mouth
- neck
- nose
- pharynx
- skull
- tongue
- vocal cord
Thorax:
- bronchus
- chest wall
- clavicle
- esophagus
- heart
- lung
- rib
- rib cage
- scapula
- sternum
- trachea
Abdomen:
- abdominal wall
- biliary tract
- kidney
- liver
- stomach
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood vessel
- peripheral nerve
- peripheral nervous system
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs and template standards for HNRNPA1
-
OriGene qPCR primer pairs for HNRNPA1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPA1 Gene
Orthologs for HNRNPA1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HNRNPA1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hnrnpa1 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | HNRNPA1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hnrnpa1 34 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | LOC100859627 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| African clawed frog (Xenopus laevis) |
Amphibia | hnrpa1-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | Dr.708 34 |
|
- Species where no ortholog for HNRNPA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HNRNPA1 Gene
Paralogs for HNRNPA1 Gene
(44) SIMAP similar genes for HNRNPA1 Gene using alignment to 7 proteins:
- HNRPA1
- D10S102
- HNRNPA2B1
- HNRNPA1L2
- HNRNPA3
- HNRPA3
- BOLL
- RBMXL3
- HNRNPA0
- CIRBP
- HNRNPD
- HNRNPAB
- RBMXL2
- RBMX
- MSI2
- HNRNPDL
- TAF15
- PABPC4
- ELAVL1
- RBM38
- PABPC1
- NCL
- RBM3
- DAZAP1/MEF2D fusion
- PABPC3
- ELAVL3
- DAZAP1
- RBM39
- PABPC4L
- PABPC1L
- ELAVL4
- ELAVL2
- DKFZp781I1140
- DKFZp781C0423
- DKFZp686C17209
- DKFZp686A11192
- CELF1
- MSI1
- SF3B4
- TARDBP
- RBM19
- RNPC4
- RBM23
- PABPC5
Pseudogenes.org Pseudogenes for HNRNPA1 Gene
- PGOHUM00000290348
- PGOHUM00000290379
- PGOHUM00000290613
- PGOHUM00000290699
- PGOHUM00000291039
- PGOHUM00000291219
- PGOHUM00000291706
- PGOHUM00000291716
- PGOHUM00000291766
- PGOHUM00000291881
- PGOHUM00000291882
- PGOHUM00000291986
- PGOHUM00000291987
- PGOHUM00000292009
- PGOHUM00000292027
- PGOHUM00000292953
- PGOHUM00000292988
- PGOHUM00000292989
- PGOHUM00000293085
- PGOHUM00000293197
- PGOHUM00000293212
- PGOHUM00000293275
- PGOHUM00000294002
- PGOHUM00000294880
- PGOHUM00000295381
- PGOHUM00000295695
- PGOHUM00000295729
- PGOHUM00000295768
- PGOHUM00000295800
- PGOHUM00000295978
- PGOHUM00000295999
- PGOHUM00000296338
- PGOHUM00000296463
- PGOHUM00000296728
- PGOHUM00000296835
- PGOHUM00000297891
- PGOHUM00000298237
- PGOHUM00000298300
- PGOHUM00000298316
- PGOHUM00000298413
- PGOHUM00000298450
- PGOHUM00000298821
- PGOHUM00000298830
- PGOHUM00000299120
- PGOHUM00000299215
- PGOHUM00000299406
- PGOHUM00000299418
- PGOHUM00000299421
- PGOHUM00000299486
- PGOHUM00000299555
- PGOHUM00000299626
- PGOHUM00000299887
- PGOHUM00000299904
- PGOHUM00000300166
- PGOHUM00000300258
- PGOHUM00000300651
- PGOHUM00000301126
- PGOHUM00000301239
- PGOHUM00000301677
- PGOHUM00000301703
- PGOHUM00000301758
- PGOHUM00000302016
- PGOHUM00000302080
- PGOHUM00000302402
- PGOHUM00000302773
- PGOHUM00000302836
- PGOHUM00000302839
- PGOHUM00000303273
- PGOHUM00000303605
- PGOHUM00000303693
- PGOHUM00000303715
- PGOHUM00000303716
- PGOHUM00000303974
- PGOHUM00000304458
- PGOHUM00000306643
- PGOHUM00000304709
- PGOHUM00000304776
- PGOHUM00000304777
- PGOHUM00000305277
- PGOHUM00000289053
- PGOHUM00000306913
- PGOHUM00000289237
- PGOHUM00000289333
- PGOHUM00000289420
- PGOHUM00000289513
- PGOHUM00000307010
- PGOHUM00000289698
- PGOHUM00000289781
- PGOHUM00000289850
- PGOHUM00000289885
- PGOHUM00000290144
Variants for HNRNPA1 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs397518452 | Pathogenic, Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 (IBMPFD3) [MIM:615424] | 54,283,845(+) | CAATG(A/T)TTTTG | nc-transcript-variant, reference, missense | |
| rs397518453 | Pathogenic, Amyotrophic lateral sclerosis 20 (ALS20) [MIM:615426] | 54,283,844(+) | ACAAT(A/G)ATTTT | nc-transcript-variant, reference, missense | |
| rs397518454 | Pathogenic, Amyotrophic lateral sclerosis 20 (ALS20) [MIM:615426] | 54,283,860(+) | TTACA(A/G)CAATC | nc-transcript-variant, reference, missense | |
| VAR_077531 | Amyotrophic lateral sclerosis 20 (ALS20) [MIM:615426] | ||||
| VAR_077533 | Amyotrophic lateral sclerosis 20 (ALS20) [MIM:615426] |
Residual Variation Intolerance Score:
33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.28;
25.60% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HNRNPA1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA1 Gene
Disorders for HNRNPA1 Gene
(10) MalaCards diseases for HNRNPA1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| inclusion body myopathy wtih early-onset paget disease without frontotemporal dementia 3 |
|
|
| amyotrophic lateral sclerosis 20 |
|
|
| hnrnpa1-related amyotrophic lateral sclerosis |
|
|
| amyotrophic lateral sclerosis 1 |
|
|
| lateral sclerosis |
|
|
Search HNRNPA1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ROA1_HUMAN- Amyotrophic lateral sclerosis 20 (ALS20) [MIM:615426]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:23455423, ECO:0000269 PubMed:27694260}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 (IBMPFD3) [MIM:615424]: An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance. {ECO:0000269 PubMed:23455423}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for HNRNPA1
No data available for Genatlas for HNRNPA1 Gene
Publications for HNRNPA1 Gene
- Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. (PMID: 23455423) Kim H.J. … Taylor J.P. (Nature 2013) 2 3 4 64
- Assignment of the human heterogeneous nuclear ribonucleoprotein A1 gene (HNRPA1) to chromosome 12q13.1 by cDNA competitive in situ hybridization. (PMID: 1733858) Saccone S. … Della Valle G. (Genomics 1992) 2 3 22 64
- Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein. (PMID: 1691095) Buvoli M. … Riva S. (EMBO J. 1990) 3 4 22 64
- Whole-exome sequencing identifies a missense mutation in hnRNPA1 in a family with flail arm ALS. (PMID: 27694260) Liu Q. … Zhang X. (Neurology 2016) 3 4 64
- ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1. (PMID: 25616961) Gilpin K.M. … Monteiro M.J. (Hum. Mol. Genet. 2015) 3 4 64
Products for HNRNPA1 Gene
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- GeneTex HNRNPA1 antibody for HNRNPA1
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- ViGene Biosciences adenoviral particle packaged cDNA for HNRNPA1 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA1 gene
- Search ViGene Biosciences for HNRNPA1
- Santa Cruz Biotechnology (SCBT) Antibodies for HNRNPA1
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- Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPA1
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- VectorBuilder custom plasmid, inducible vectors for HNRNPA1
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HNRNPA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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- (13) InterPro
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- (15) Blocks
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer