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Aliases for HNRNPA1 Gene

Aliases for HNRNPA1 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A1 2 3
  • Single-Strand RNA-Binding Protein 3 4
  • Helix-Destabilizing Protein 3 4
  • HnRNP Core Protein A1 3 4
  • HnRNP A1 3 4
  • IBMPFD3 3 6
  • HNRPA1 3 4
  • ALS20 3 6
  • Putative Heterogeneous Nuclear Ribonucleoprotein A1-Like 3 3
  • Heterogeneous Nuclear Ribonucleoprotein Core Protein A1 3
  • Heterogeneous Nuclear Ribonucleoprotein A1B Protein 3
  • Heterogeneous Nuclear Ribonucleoprotein B2 Protein 3
  • Nuclear Ribonucleoprotein Particle A1 Protein 3
  • Single-Strand DNA-Binding Protein UP1 3
  • HnRNP Core Protein A1-Like 3 3
  • HnRNP A1-Like 3 3
  • HNRPA1L3 3
  • HnRNP-A1 3
  • ALS19 3

External Ids for HNRNPA1 Gene

Previous HGNC Symbols for HNRNPA1 Gene

  • HNRPA1

Previous GeneCards Identifiers for HNRNPA1 Gene

  • GC12P052961
  • GC12P054674
  • GC12P051713

Summaries for HNRNPA1 Gene

Entrez Gene Summary for HNRNPA1 Gene

  • This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPA1 Gene

HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) is a Protein Coding gene. Diseases associated with HNRNPA1 include amyotrophic lateral sclerosis 20 and inclusion body myopathy wtih early-onset paget disease without frontotemporal dementia 3. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include RNA binding and single-stranded DNA binding. An important paralog of this gene is HNRNPA0.

UniProtKB/Swiss-Prot for HNRNPA1 Gene

  • Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.

Gene Wiki entry for HNRNPA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA1 Gene

Genomics for HNRNPA1 Gene

Regulatory Elements for HNRNPA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HNRNPA1 Gene

Start:
54,280,193 bp from pter
End:
54,287,088 bp from pter
Size:
6,896 bases
Orientation:
Plus strand

Genomic View for HNRNPA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA1 Gene

Proteins for HNRNPA1 Gene

  • Protein details for HNRNPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09651-ROA1_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A1
    Protein Accession:
    P09651
    Secondary Accessions:
    • A8K4Z8
    • Q3MIB7
    • Q6PJZ7

    Protein attributes for HNRNPA1 Gene

    Size:
    372 amino acids
    Molecular mass:
    38747 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SEPT6. Interacts with C9orf72. Interacts with HCV NS5B and with the 5-UTR and 3-UTR of HCV RNA. Interacts with UBQLN2 (PubMed:25616961).

    Three dimensional structures from OCA and Proteopedia for HNRNPA1 Gene

    Alternative splice isoforms for HNRNPA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPA1 Gene

Proteomics data for HNRNPA1 Gene at MOPED

Post-translational modifications for HNRNPA1 Gene

  • Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine
  • Sumoylated.
  • Ubiquitination at Lys3, Lys8, Lys15, Lys52, Lys78, and Lys350
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HNRNPA1 (hnRNP A1)

No data available for DME Specific Peptides for HNRNPA1 Gene

Domains for HNRNPA1 Gene

Gene Families for HNRNPA1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for HNRNPA1 Gene

Suggested Antigen Peptide Sequences for HNRNPA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09651

UniProtKB/Swiss-Prot:

ROA1_HUMAN :
  • P09651
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPA1: view

Function for HNRNPA1 Gene

Molecular function for HNRNPA1 Gene

UniProtKB/Swiss-Prot Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.

Gene Ontology (GO) - Molecular Function for HNRNPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003697 single-stranded DNA binding IDA 8521471
GO:0003723 RNA binding TAS 8521471
GO:0003727 single-stranded RNA binding IC 8521471
genes like me logo Genes that share ontologies with HNRNPA1: view

Phenotypes for HNRNPA1 Gene

GenomeRNAi human phenotypes for HNRNPA1:
genes like me logo Genes that share phenotypes with HNRNPA1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPA1 Gene

Localization for HNRNPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA1 Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPA1 Gene COMPARTMENTS Subcellular localization image for HNRNPA1 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 1

Gene Ontology (GO) - Cellular Components for HNRNPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HNRNPA1: view

Pathways for HNRNPA1 Gene

genes like me logo Genes that share pathways with HNRNPA1: view

Pathways by source for HNRNPA1 Gene

1 Qiagen pathway for HNRNPA1 Gene
1 Cell Signaling Technology pathway for HNRNPA1 Gene
2 BioSystems pathways for HNRNPA1 Gene

Gene Ontology (GO) - Biological Process for HNRNPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome IEA --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing TAS 8521471
GO:0006405 RNA export from nucleus IC 8521471
GO:0008219 cell death --
genes like me logo Genes that share ontologies with HNRNPA1: view

Compounds for HNRNPA1 Gene

(1) Novoseek inferred chemical compound relationships for HNRNPA1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 0 1
genes like me logo Genes that share compounds with HNRNPA1: view

Transcripts for HNRNPA1 Gene

Unigene Clusters for HNRNPA1 Gene

Heterogeneous nuclear ribonucleoprotein A1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13
SP1:
SP2:
SP3:
SP4: - - -
SP5:
SP6: -
SP7: - - - - - - - -
SP8:
SP9: - -

Relevant External Links for HNRNPA1 Gene

GeneLoc Exon Structure for
HNRNPA1
ECgene alternative splicing isoforms for
HNRNPA1

Expression for HNRNPA1 Gene

mRNA expression in normal human tissues for HNRNPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPA1 Gene

SOURCE GeneReport for Unigene cluster for HNRNPA1 Gene Hs.546261

genes like me logo Genes that share expressions with HNRNPA1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPA1 Gene

Orthologs for HNRNPA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HNRNPA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPA1 35
  • 99.58 (n)
  • 100 (a)
HNRNPA1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HNRNPA1 35
  • 94.27 (n)
  • 100 (a)
HNRNPA1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 86 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 88 (a)
ManyToMany
-- 36
  • 91 (a)
ManyToMany
-- 36
  • 88 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hnrnpa1 16
Hnrnpa1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
-- 36
  • 86 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hnrnpa1 35
  • 92.4 (n)
  • 99.69 (a)
chicken
(Gallus gallus)
Aves LOC100859627 35
  • 76.72 (n)
  • 84.91 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia hnrpa1-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.708 35
Species with no ortholog for HNRNPA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPA1 Gene

ENSEMBL:
Gene Tree for HNRNPA1 (if available)
TreeFam:
Gene Tree for HNRNPA1 (if available)

Paralogs for HNRNPA1 Gene

Paralogs for HNRNPA1 Gene

Pseudogenes.org Pseudogenes for HNRNPA1 Gene

genes like me logo Genes that share paralogs with HNRNPA1: view

Variants for HNRNPA1 Gene

Sequence variations from dbSNP and Humsavar for HNRNPA1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs6717 -- 54,287,022(-) GAACA(A/G)CTCAT utr-variant-3-prime, nc-transcript-variant
rs12656 -- 54,286,558(+) TCCCC(A/T)AATGG intron-variant
rs1135894 -- 54,284,879(+) TTTTT(A/T)AATGT utr-variant-3-prime, intron-variant
rs3206707 other 54,284,305(+) GCAGA(A/G/T)GATTT reference, missense, nc-transcript-variant
rs3953255 -- 54,284,843(+) TGTAA(C/T)AGTCT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA1 Gene

Variant ID Type Subtype PubMed ID
nsv832420 CNV Loss 17160897
esv25123 CNV Loss 19812545

Relevant External Links for HNRNPA1 Gene

HapMap Linkage Disequilibrium report
HNRNPA1
Human Gene Mutation Database (HGMD)
HNRNPA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA1 Gene

Disorders for HNRNPA1 Gene

(2) OMIM Diseases for HNRNPA1 Gene (164017)

UniProtKB/Swiss-Prot

ROA1_HUMAN
  • Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 (IBMPFD3) [MIM:615424]: An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance. {ECO:0000269 PubMed:23455423}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Amyotrophic lateral sclerosis 20 (ALS20) [MIM:615426]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:23455423}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for HNRNPA1 Gene

(7) Novoseek inferred disease relationships for HNRNPA1 Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 37.6 2
mimicry 25.7 2
immunodeficiency 21.2 2
colorectal cancer 8.21 1
tumors 0 1

Relevant External Links for HNRNPA1

Genetic Association Database (GAD)
HNRNPA1
Human Genome Epidemiology (HuGE) Navigator
HNRNPA1
genes like me logo Genes that share disorders with HNRNPA1: view

Publications for HNRNPA1 Gene

  1. Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein. (PMID: 1691095) Buvoli M. … Riva S. (EMBO J. 1990) 3 4 23
  2. Assignment of the human heterogeneous nuclear ribonucleoprotein A1 gene (HNRPA1) to chromosome 12q13.1 by cDNA competitive in situ hybridization. (PMID: 1733858) Saccone S. … Della Valle G. (Genomics 1992) 2 3 23
  3. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. (PMID: 23455423) Kim H.J. … Taylor J.P. (Nature 2013) 2 3 4
  4. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Joeson L. … Nielsen F.C. (Mol. Cell. Proteomics 2007) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for HNRNPA1 Gene

Sources for HNRNPA1 Gene

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