Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HNRNPA0 Gene

Aliases for HNRNPA0 Gene

  • Heterogeneous Nuclear Ribonucleoprotein A0 2 3 5
  • HnRNP A0 3 4
  • HNRPA0 3 4
  • HnRNA Binding Protein 3

External Ids for HNRNPA0 Gene

Previous HGNC Symbols for HNRNPA0 Gene

  • HNRPA0

Previous GeneCards Identifiers for HNRNPA0 Gene

  • GC05M137114
  • GC05M132277

Summaries for HNRNPA0 Gene

Entrez Gene Summary for HNRNPA0 Gene

  • This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPA0 Gene

HNRNPA0 (Heterogeneous Nuclear Ribonucleoprotein A0) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation and Translational Control. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPDL.

UniProtKB/Swiss-Prot for HNRNPA0 Gene

  • mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.

Gene Wiki entry for HNRNPA0 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA0 Gene

Genomics for HNRNPA0 Gene

Regulatory Elements for HNRNPA0 Gene

Enhancers for HNRNPA0 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HNRNPA0 on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPA0 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HNRNPA0 on UCSC Golden Path with GeneCards custom track

Genomic Location for HNRNPA0 Gene

Chromosome:
5
Start:
137,745,651 bp from pter
End:
137,754,376 bp from pter
Size:
8,726 bases
Orientation:
Minus strand

Genomic View for HNRNPA0 Gene

Genes around HNRNPA0 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPA0 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPA0 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPA0 Gene

Proteins for HNRNPA0 Gene

  • Protein details for HNRNPA0 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13151-ROA0_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A0
    Protein Accession:
    Q13151
    Secondary Accessions:
    • Q6IB18

    Protein attributes for HNRNPA0 Gene

    Size:
    305 amino acids
    Molecular mass:
    30841 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HNRNPA0 Gene

Proteomics data for HNRNPA0 Gene at MOPED

Post-translational modifications for HNRNPA0 Gene

  • Arg-291 is dimethylated, probably to asymmetric dimethylarginine.
  • Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA.
  • Ubiquitination at Lys 45, Lys 80, Lys 106, Lys 133, and Lys 172
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPA0 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HNRNPA0 (hnRNP A0)

No data available for DME Specific Peptides for HNRNPA0 Gene

Domains & Families for HNRNPA0 Gene

Gene Families for HNRNPA0 Gene

Protein Domains for HNRNPA0 Gene

Suggested Antigen Peptide Sequences for HNRNPA0 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13151

UniProtKB/Swiss-Prot:

ROA0_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPA0: view

Function for HNRNPA0 Gene

Molecular function for HNRNPA0 Gene

UniProtKB/Swiss-Prot Function:
mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.

Gene Ontology (GO) - Molecular Function for HNRNPA0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 20932473
genes like me logo Genes that share ontologies with HNRNPA0: view
genes like me logo Genes that share phenotypes with HNRNPA0: view

Animal Model Products

miRNA for HNRNPA0 Gene

miRTarBase miRNAs that target HNRNPA0

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA0 Gene

Localization for HNRNPA0 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA0 Gene

Nucleus. Note=Component of ribonucleosomes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPA0 Gene COMPARTMENTS Subcellular localization image for HNRNPA0 gene
Compartment Confidence
nucleus 5
cytosol 1
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for HNRNPA0 Gene

Pathways & Interactions for HNRNPA0 Gene

genes like me logo Genes that share pathways with HNRNPA0: view

Pathways by source for HNRNPA0 Gene

Gene Ontology (GO) - Biological Process for HNRNPA0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing TAS 7585247
GO:0070935 3-UTR-mediated mRNA stabilization IEA,TAS 20932473
genes like me logo Genes that share ontologies with HNRNPA0: view

No data available for SIGNOR curated interactions for HNRNPA0 Gene

Drugs & Compounds for HNRNPA0 Gene

No Compound Related Data Available

Transcripts for HNRNPA0 Gene

mRNA/cDNA for HNRNPA0 Gene

(1) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(628) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HNRNPA0 Gene

Heterogeneous nuclear ribonucleoprotein A0:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPA0 Gene

No ASD Table

Relevant External Links for HNRNPA0 Gene

GeneLoc Exon Structure for
HNRNPA0
ECgene alternative splicing isoforms for
HNRNPA0

Expression for HNRNPA0 Gene

mRNA expression in normal human tissues for HNRNPA0 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HNRNPA0 Gene

This gene is overexpressed in Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPA0 Gene



SOURCE GeneReport for Unigene cluster for HNRNPA0 Gene Hs.96996

genes like me logo Genes that share expression patterns with HNRNPA0: view

Protein tissue co-expression partners for HNRNPA0 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPA0 Gene

Orthologs for HNRNPA0 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPA0 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HNRNPA0 35
  • 94.3 (n)
  • 99.67 (a)
HNRPA0 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpa0 16
Hnrnpa0 36
  • 93 (a)
OneToOne
Hnrnpa0 35
  • 83.21 (n)
  • 89.55 (a)
oppossum
(Monodelphis domestica)
Mammalia HNRNPA0 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPA0 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HNRNPA0 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPA0 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC681410 35
  • 85.19 (n)
  • 91.67 (a)
chicken
(Gallus gallus)
Aves HNRNPA0 35
  • 78.86 (n)
  • 85.45 (a)
HNRNPA0 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPA0 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpa0 35
  • 68.43 (n)
  • 70.94 (a)
MGC75874 35
African clawed frog
(Xenopus laevis)
Amphibia hnrpa0-prov 35
zebrafish
(Danio rerio)
Actinopterygii wufc01g05 35
hnrnpa0a 36
  • 60 (a)
OneToMany
hnrnpa0b 36
  • 59 (a)
OneToMany
hnrnpa0l 36
  • 58 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6239 35
fruit fly
(Drosophila melanogaster)
Insecta Hrb87F 36
  • 36 (a)
ManyToMany
Hrb98DE 36
  • 35 (a)
ManyToMany
Rb97D 36
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-1 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10370 36
  • 27 (a)
OneToMany
Species with no ortholog for HNRNPA0:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPA0 Gene

ENSEMBL:
Gene Tree for HNRNPA0 (if available)
TreeFam:
Gene Tree for HNRNPA0 (if available)

Paralogs for HNRNPA0 Gene

Paralogs for HNRNPA0 Gene

(17) SIMAP similar genes for HNRNPA0 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HNRNPA0: view

Variants for HNRNPA0 Gene

Sequence variations from dbSNP and Humsavar for HNRNPA0 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs7875 -- 137,752,360(-) AGCGA(A/G)TTGTT utr-variant-3-prime
rs1050179 -- 137,751,634(-) CCTTT(C/T)TGGAT utr-variant-3-prime
rs1130987 -- 137,751,596(-) ATATC(A/C)CAAAT utr-variant-3-prime
rs3177854 -- 137,752,622(-) GTTTG(A/C)CCGTA utr-variant-3-prime
rs34134703 -- 137,755,117(+) GTTTA(-/A)CAGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HNRNPA0 Gene

Variant ID Type Subtype PubMed ID
nsv830500 CNV Loss 17160897
nsv819360 CNV Gain 19587683

Variation tolerance for HNRNPA0 Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNRNPA0 Gene

HapMap Linkage Disequilibrium report
HNRNPA0
Human Gene Mutation Database (HGMD)
HNRNPA0

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA0 Gene

Disorders for HNRNPA0 Gene

Relevant External Links for HNRNPA0

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNRNPA0

No disorders were found for HNRNPA0 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPA0 Gene

Publications for HNRNPA0 Gene

  1. Isolation and characterization of a novel, low abundance hnRNP protein: A0. (PMID: 7585247) Myer V.E. … Steitz J.A. (RNA 1995) 2 3 4 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3

Products for HNRNPA0 Gene

Sources for HNRNPA0 Gene

Content