Aliases for HNRNPA0 Gene
Aliases for HNRNPA0 Gene
External Ids for HNRNPA0 Gene
- HGNC: 5030
- Entrez Gene: 10949
- Ensembl: ENSG00000177733
- OMIM: 609409
- UniProtKB: Q13151
Previous HGNC Symbols for HNRNPA0 Gene
- HNRPA0
Previous GeneCards Identifiers for HNRNPA0 Gene
- GC05M137114
- GC05M132277
Summaries for HNRNPA0 Gene
-
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNRNPA0 Gene
HNRNPA0 (Heterogeneous Nuclear Ribonucleoprotein A0) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPA3.
UniProtKB/Swiss-Prot for HNRNPA0 Gene
-
mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPA0 Gene
Genomics for HNRNPA0 Gene
Regulatory Elements for HNRNPA0 Gene
- Transcription factor binding sites by QIAGEN in the HNRNPA0 gene promoter:
Regulatory Element Products
Genomic Location for HNRNPA0 Gene
- Chromosome:
- 5
- Start:
- 137,745,651 bp from pter
- End:
- 137,754,376 bp from pter
- Size:
- 8,726 bases
- Orientation:
- Minus strand
Genomic View for HNRNPA0 Gene
- Cytogenetic band:
-
- 5q31.2 by Ensembl
- 5q31.2 by Entrez Gene
- 5q31.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HNRNPA0 Gene
Proteins for HNRNPA0 Gene
-
Protein details for HNRNPA0 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13151-ROA0_HUMAN
- Recommended name:
- Heterogeneous nuclear ribonucleoprotein A0
- Protein Accession:
- Q13151
- Q6IB18
Protein attributes for HNRNPA0 Gene
- Size:
- 305 amino acids
- Molecular mass:
- 30841 Da
- Quaternary structure:
- No Data Available
Protein Expression for HNRNPA0 Gene
Post-translational modifications for HNRNPA0 Gene
- Arg-291 is dimethylated, probably to asymmetric dimethylarginine.
- Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA.
- Ubiquitination at isoforms=45, posLast=8080, posLast=106106, posLast=133133, and posLast=172172
- Modification sites at PhosphoSitePlus
Other Protein References for HNRNPA0 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HNRNPA0
- Cell Signaling Technology (CST) Antibodies for HNRNPA0 (hnRNP A0)
- Novus Biologicals Antibodies for HNRNPA0
- Invitrogen Antibodies for HNRNPA0
- antibodies-online Antibodies for HNRNPA0: See all 21
- Search GeneTex for Antibodies for HNRNPA0
Protein Products
-
OriGene Purified Proteins for HNRNPA0
- Search Origene for MassSpec and Protein Over-expression Lysates for HNRNPA0
- Origene Custom Protein Services for HNRNPA0
- antibodies-online Proteins for HNRNPA0: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HNRNPA0
Assay Products
No data available for DME Specific Peptides for HNRNPA0 Gene
Domains & Families for HNRNPA0 Gene
Gene Families for HNRNPA0 Gene
Protein Domains for HNRNPA0 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HNRNPA0 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HNRNPA0 Gene
Function for HNRNPA0 Gene
Molecular function for HNRNPA0 Gene
- UniProtKB/Swiss-Prot Function:
- mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IDA,TAS | 22658674 |
| GO:0017091 | AU-rich element binding | IDA | 20932473 |
| GO:0019901 | protein kinase binding | IPI | 20932473 |
Phenotypes for HNRNPA0 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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ViGene Biosciences lentiviral particle packaged cDNA for HNRNPA0 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA0 gene
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CRISPR Products
-
OriGene CRISPR knockouts for HNRNPA0
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPA0
- GenScript: Design CRISPR guide RNA sequences for HNRNPA0
miRNA for HNRNPA0 Gene
- miRTarBase miRNAs that target HNRNPA0
-
- hsa-mir-221-3p (MIRT024198)
- hsa-mir-615-3p (MIRT040287)
- hsa-mir-548a-3p (MIRT040513)
- hsa-mir-484 (MIRT042000)
- hsa-mir-423-3p (MIRT042630)
- hsa-mir-324-3p (MIRT042915)
- hsa-mir-6083 (MIRT095236)
- hsa-mir-4766-5p (MIRT165480)
- hsa-mir-590-3p (MIRT214647)
- hsa-mir-4282 (MIRT214650)
- hsa-mir-466 (MIRT214656)
- hsa-mir-4643 (MIRT214658)
- hsa-mir-4672 (MIRT214659)
- hsa-mir-4789-3p (MIRT214660)
- hsa-mir-511-3p (MIRT311937)
- hsa-mir-552-5p (MIRT357416)
- hsa-mir-186-5p (MIRT357419)
- hsa-mir-6507-5p (MIRT357424)
- hsa-mir-146a-3p (MIRT357490)
- hsa-mir-4495 (MIRT443560)
- hsa-mir-3156-5p (MIRT443561)
- hsa-mir-6792-5p (MIRT507010)
- hsa-mir-555 (MIRT507011)
- hsa-mir-4795-5p (MIRT507012)
- hsa-mir-6814-5p (MIRT507013)
- hsa-mir-6796-5p (MIRT511478)
- hsa-mir-297 (MIRT511479)
- hsa-mir-1227-5p (MIRT511480)
- hsa-mir-223-5p (MIRT511481)
- hsa-mir-6742-5p (MIRT511482)
- hsa-mir-4472 (MIRT511483)
- hsa-mir-4447 (MIRT511484)
- hsa-mir-3151-5p (MIRT511485)
- hsa-mir-567 (MIRT511486)
- hsa-mir-128-2-5p (MIRT511487)
- hsa-mir-128-1-5p (MIRT511488)
- hsa-mir-6845-5p (MIRT511489)
- hsa-mir-6762-5p (MIRT511490)
- hsa-mir-6877-5p (MIRT511491)
- hsa-mir-4657 (MIRT511492)
- hsa-mir-4491 (MIRT511493)
- hsa-mir-299-3p (MIRT511494)
- hsa-mir-491-5p (MIRT511495)
- hsa-mir-1304-5p (MIRT547938)
- hsa-mir-6805-3p (MIRT547939)
- hsa-mir-5691 (MIRT547940)
- hsa-mir-6734-5p (MIRT547941)
- hsa-mir-1226-5p (MIRT547942)
- hsa-mir-6834-5p (MIRT547943)
- hsa-mir-3194-3p (MIRT547944)
- hsa-mir-6804-5p (MIRT547945)
- hsa-mir-3912-3p (MIRT547946)
- hsa-mir-6732-3p (MIRT547947)
- hsa-mir-652-5p (MIRT547948)
- hsa-mir-8054 (MIRT547949)
- hsa-mir-548k (MIRT547950)
- hsa-mir-548av-5p (MIRT547951)
- hsa-mir-410-3p (MIRT547952)
- hsa-mir-6884-3p (MIRT547953)
- hsa-mir-5007-5p (MIRT547954)
- hsa-mir-3691-3p (MIRT547955)
- hsa-mir-3121-3p (MIRT547956)
- hsa-mir-4529-5p (MIRT567297)
- hsa-mir-15a-3p (MIRT567298)
- hsa-mir-6809-3p (MIRT567299)
- hsa-mir-6833-3p (MIRT567300)
- hsa-mir-4768-5p (MIRT567301)
- hsa-mir-4684-5p (MIRT567302)
- hsa-mir-520f-5p (MIRT567303)
- hsa-mir-943 (MIRT567304)
- hsa-mir-4257 (MIRT567305)
- hsa-mir-6847-5p (MIRT567306)
- hsa-mir-573 (MIRT574699)
- hsa-mir-3616-5p (MIRT574700)
- hsa-mir-5585-5p (MIRT574701)
- hsa-mir-548ax (MIRT574702)
- hsa-mir-548ao-5p (MIRT574703)
- hsa-mir-6768-5p (MIRT574704)
- hsa-mir-376a-3p (MIRT574705)
- hsa-mir-376b-3p (MIRT574706)
- hsa-mir-26a-5p (MIRT727488)
- hsa-mir-26b-5p (MIRT727489)
miRNA Products
- Search ViGene Biosciences for HNRNPA0
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HNRNPA0
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-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA0 gene
Clone Products
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Cell Line Products
-
Horizon Cell Lines for HNRNPA0
-
ViGene Biosciences adenoviral particle packaged cDNA for HNRNPA0 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HNRNPA0 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPA0 Gene
Localization for HNRNPA0 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HNRNPA0 Gene
- Nucleus. Note=Component of ribonucleosomes. {ECO:0000250}.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 7585247 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0030529 | intracellular ribonucleoprotein complex | IEA | -- |
Pathways & Interactions for HNRNPA0 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
|
| 2 | Chromatin Regulation / Acetylation | ||
| 3 | Translational Control | ||
| 4 | Gene Expression |
.48
|
|
Pathways by source for HNRNPA0 Gene
2 Cell Signaling Technology pathways for HNRNPA0 Gene
4 Reactome pathways for HNRNPA0 Gene
Interacting Proteins for HNRNPA0 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006397 | mRNA processing | TAS | 7585247 |
| GO:0006954 | inflammatory response | ISS,IEA | -- |
| GO:0010467 | gene expression | TAS | -- |
| GO:0016070 | RNA metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for HNRNPA0 Gene
Transcripts for HNRNPA0 Gene
mRNA/cDNA for HNRNPA0 Gene
- (1) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (628) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HNRNPA0 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HNRNPA0
-
Santa Cruz Biotechnology (SCBT) CRISPR for HNRNPA0
- GenScript: Design CRISPR guide RNA sequences for HNRNPA0
miRNA Products
- Search ViGene Biosciences for HNRNPA0
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HNRNPA0
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-
ViGene Biosciences ready-to-package AAV shRNAs for HNRNPA0 gene
Clone Products
-
OriGene ORF clones in human for HNRNPA0
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Flow Cytometry Products
Expression for HNRNPA0 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNRNPA0 Gene
NURSA nuclear receptor signaling pathways regulating expression of HNRNPA0 Gene:
HNRNPA0SOURCE GeneReport for Unigene cluster for HNRNPA0 Gene:
Hs.96996Evidence on tissue expression from TISSUES for HNRNPA0 Gene
- Nervous system(4.7)
- Lung(4.6)
- Muscle(4.5)
- Eye(4.4)
- Liver(4.4)
- Skin(4.4)
- Stomach(2.3)
- Heart(2.2)
- Intestine(2.2)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for HNRNPA0
-
OriGene qPCR primer pairs for HNRNPA0
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNRNPA0 Gene
Orthologs for HNRNPA0 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HNRNPA0 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HNRPA0 35 |
|
OneToOne | |
| HNRNPA0 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | HNRNPA0 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HNRNPA0 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | LOC681410 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hnrnpa0 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HNRNPA0 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HNRNPA0 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HNRNPA0 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hnrnpa0 34 |
|
||
| MGC75874 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | hnrpa0-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hnrnpa0a 35 |
|
OneToMany | |
| hnrnpa0b 35 |
|
OneToMany | |||
| hnrnpa0l 35 |
|
OneToMany | |||
| wufc01g05 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6239 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Hrb87F 35 |
|
ManyToMany | |
| Hrb98DE 35 |
|
ManyToMany | |||
| Rb97D 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | hrp-1 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HRP1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10370 35 |
|
OneToMany |
- Species where no ortholog for HNRNPA0 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HNRNPA0 Gene
Paralogs for HNRNPA0 Gene
(17) SIMAP similar genes for HNRNPA0 Gene using alignment to 1 proteins:
Variants for HNRNPA0 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000328463 | -- | 137,755,130(+) | CCCGA(C/T)GTGCG | upstream-variant-2KB | |
| rs1000408900 | -- | 137,756,220(+) | CCATA(C/T)GGTAA | upstream-variant-2KB | |
| rs1000803343 | -- | 137,751,838(+) | AGCTA(C/T)GCATA | utr-variant-3-prime | |
| rs1000828489 | -- | 137,751,439(+) | TCTTA(C/G)TATAG | utr-variant-3-prime | |
| rs1000902001 | -- | 137,751,119(+) | TGTAC(-/AACT)ATTTG | downstream-variant-500B |
Relevant External Links for HNRNPA0 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPA0 Gene
Disorders for HNRNPA0 Gene
Relevant External Links for HNRNPA0
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HNRNPA0
No disorders were found for HNRNPA0 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HNRNPA0 Gene
Publications for HNRNPA0 Gene
- Isolation and characterization of a novel, low abundance hnRNP protein: A0. (PMID: 7585247) Myer V.E. … Steitz J.A. (RNA 1995) 2 3 4 64
- DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. (PMID: 20932473) Reinhardt H.C. … Yaffe M.B. (Mol. Cell 2010) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP- K2 and its interaction with cytokine mRNAs. (PMID: 12456657) Rousseau S. … Cohen P. (EMBO J. 2002) 3 4 64
- The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L. … Hanemann C.O. (Oncogene 2016) 3 64
Products for HNRNPA0 Gene
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- antibodies-online Antibodies for HNRNPA0: See all 21
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- antibodies-online Proteins for HNRNPA0: See all 5
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- ViGene Biosciences adenoviral particle packaged cDNA for HNRNPA0 gene
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- VectorBuilder custom plasmid, inducible vectors for HNRNPA0
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HNRNPA0 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
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