External Ids for HNMT Gene
Previous GeneCards Identifiers for HNMT Gene
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNMT Gene
HNMT (Histamine N-Methyltransferase) is a Protein Coding gene. Diseases associated with HNMT include asthma and heel spur. Among its related pathways are Metabolism and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include N-methyltransferase activity and histamine N-methyltransferase activity.
UniProtKB/Swiss-Prot for HNMT Gene
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine
Histone methyltransferases (HMTs) are a group of enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to histones. This occurs predominantly on the side chains of lysine and arginine residues in histones H3 and H4.