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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNMT Gene

protein-coding   GIFtS: 64
GCID: GC02P138744

histamine N-methyltransferase
 Explore 42 diseases affiliated with
HNMT via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HNMT    

Aliases
for HNMT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histamine N-Methyltransferase1 2
HMT2 3
EC 2.1.1.83 8
HNMT-S12
HNMT-S22

External Ids:    HGNC: 50281   Entrez Gene: 31762   Ensembl: ENSG000001505407   OMIM: 6052385   UniProtKB: P501353   

Export aliases for HNMT gene to outside databases

Previous GC identifers: GC02P136386 GC02P137029 GC02P138932 GC02P138555 GC02P138438 GC02P130713


Summaries
for HNMT gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HNMT:
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and
oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses
S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is
controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic
polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced
transcript variants that encode different proteins have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HNMT_HUMAN, P50135
Function: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the
airway response to histamine

summary for HNMT:
Histamine N-methyltransferase (HMT) catalyzes the metabolism of histamine. It is ubiquitously expressed and
the level of this enzyme is a critical factor in airway responsiveness to histamine.




Genomic Views
for HNMT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNMT gene promoter:
         SRF   SRF (504 AA)   ATF-2   Cdc5   E47   POU2F1   POU2F1b   HFH-1   POU2F1a   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HNMT promoter sequence
   Search SABiosciences Chromatin IP Primers for HNMT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q22.1   Ensembl cytogenetic band:  2q22.1   HGNC cytogenetic band: 2q22.1

HNMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNMT gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P138744:  view genomic region     (about GC identifiers)

Start:
 138,721,590 bp from pter      End:
 138,773,934 bp from pter
Size:
 52,345 bases      Orientation:
 plus strand

Proteins
for HNMT gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HNMT_HUMAN, P50135 (See protein sequence)
Recommended Name: Histamine N-methyltransferase  
Size: 292 amino acids; 33295 Da
Subunit: Monomer
Subcellular location: Cytoplasm
6/8 PDB 3D structures from and Proteopedia for HNMT (see all 8):
1ICZ (3D)        1JQD (3D)        1JQE (3D)        2AOT (3D)        2AOU (3D)        2AOV (3D)    
Secondary accessions: B2R9J3 Q546Z6 Q7Z7I2 Q8IU56 Q8WW98 Q9BRW6
Alternative splicing: 3 isoforms:  P50135-1   P50135-2   P50135-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HNMT: NX_P50135

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P50135

    • 4/8 DME Specific Peptides for HNMT (P50135) (see all 8)
     DFLTETC  VEPSAEQI  LSIGGGAGE  WHKETSSEYQ 

    HNMT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001019245.1  NP_001019246.1  NP_008826.1  

    ENSEMBL proteins: 
     ENSP00000386940   ENSP00000333259   ENSP00000280097   ENSP00000280096   ENSP00000419415  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: HNMT
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    Novus Biologicals HNMT Proteins
    Novus Biologicals HNMT Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for HNMT
    Uscn Proteins for HNMT

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0019717synaptosome ----
    GO:0043005neuron projection IEA--


    HNMT for ontologies           About GeneDecksing



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    ThermoFisher Antibody for HNMT

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    Uscn ELISAs and CLIAs for HNMT

    Protein Domains /
    Families
    for HNMT gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HNMT for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR016673 Histamine_N-methyltransferase

    Graphical View of Domain Structure for InterPro Entry P50135

    ProtoNet protein and cluster: P50135

    UniProtKB/Swiss-Prot: HNMT_HUMAN, P50135
    Similarity: Belongs to the methyltransferase superfamily. HNMT family


    Function
    for HNMT gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HNMT_HUMAN, P50135
    Function: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the
    airway response to histamine
    Catalytic activity: S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine

         Genatlas biochemistry entry for HNMT:
    histamine N-methyltransferase,S-adenosyl-L-methionine dependent cytosolic enzyme

    Enzyme Number (IUBMB): EC 2.1.1.81 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HNMT
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate HNMT (see all 23):
    hsa-miR-579 hsa-miR-100* hsa-miR-4311 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-134 hsa-miR-3129-5p hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmid: HNMT 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HNMT (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008170N-methyltransferase activity ----
    GO:0046539histamine N-methyltransferase activity IEA--


    HNMT for ontologies           About GeneDecksing



    Pathways & Interactions
    for HNMT gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1histamine degradation
    		histamine degradation1.00
    2Histidine metabolism
    		Histidine metabolism1.00
    3Biological oxidations
    		metapathway biotransformation0.41

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for HNMT 
        histamine degradation
    metapathway biotransformation


    1         Kegg Pathway  (Kegg details for HNMT):
        Histidine metabolism


    HNMT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HNMT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for HNMT (ENSP000002800974) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABP1ENSP000003541934STRING: ENSP00000354193
    DDCENSP000003506164STRING: ENSP00000350616
    HDCENSP000002678454STRING: ENSP00000267845
    MAOAENSP000003406844STRING: ENSP00000340684
    MAOBENSP000003673094STRING: ENSP00000367309
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002347response to tumor cell IEA--
    GO:0006950response to stress ----
    GO:0006972hyperosmotic response IEA--
    GO:0007420brain development IEA--
    GO:0007585respiratory gaseous exchange TAS7943261


    HNMT for ontologies           About GeneDecksing



    Drugs & Compounds
    for HNMT gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HNMT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HNMT available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SKF 91488 dihydrochlorideHistamine N-methyltransferase inhibitor[68643-23-2]

    4 HMDB Compounds for HNMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Methylhistamine1-Methyl-1H-imidazole-4-ethanamine (see all 21)501-75-7--
    Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    7 DrugBank Compounds for HNMT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AmodiaquineAmodiaquin (see all 4)86-42-0targetinhibitor17222819 1203620 6789797 11752352
    Histamine Phosphate-- 51-74-1enzymesubstrate19450133 8750789
    Quinacrine-- 83-89-6enzymeinhibitor12713826 3933141
    4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE-- --target--10592235
    ChlorhexidineChlorhexidin [Czech] (see all 4)55-56-1enzymeinhibitor3337739
    METOPRINE, METHODICHLOROPHEN-- --target--10592235
    S-Adenosyl-L-Homocysteine-- 979-92-0target----
    enzyme----

    10/16 Novoseek chemical compound relationships for HNMT gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    histamine 86.8 349 7875186 (5), 11475331 (5), 7943261 (5), 19178400 (4) (see all 84)
    hydrazine 82.9 40 1588129 (1), 15054605 (1), 17562176 (1), 19899403 (1) (see all 21)
    aminoquinoline 73.6 2 11855993 (1), 12713826 (1)
    amodiaquine 57.1 3 1907425 (1), 16168438 (1), 8145732 (1)
    thiopurine 54.8 5 10331075 (2), 9667080 (2)
    toluene diisocyanate 51.4 6 1960592 (2), 8396495 (1)
    diphenhydramine 46.9 2 18789706 (1), 16168438 (1)
    histidine 46.4 13 9148245 (2), 1588129 (1), 1960592 (1), 8448680 (1) (see all 7)
    s-adenosylmethionine 45.4 8 11566133 (1), 11475331 (1), 8147263 (1), 8145732 (1)
    tacrine 38.4 9 15834447 (4), 16168438 (1)

    Search CenterWatch for drugs/clinical trials and news about HNMT 

    Transcripts
    for HNMT gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HNMT gene (3 alternative transcripts): 
    NM_001024074.2  NM_001024075.1  NM_006895.2  

    Unigene Cluster for HNMT:

    Histamine N-methyltransferase
    Hs.42151  [show with all ESTs]
    Unigene Representative Sequence: NM_006895
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000410115 ENST00000329366(uc002tve.3) ENST00000280097(uc002tvf.3)
    ENST00000280096(uc002tvd.3) ENST00000475675 ENST00000467390 ENST00000485653
    ENST00000480534

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate HNMT (see all 23):
    hsa-miR-579 hsa-miR-100* hsa-miR-4311 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-134 hsa-miR-3129-5p hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmid: HNMT 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF523356.1 AF523357.1 AF523358.1 AF523359.1 AF523360.1 AK301462.1 AK313804.1 BC005907.1 
    BC020677.1 D16224.1 U08092.1 

    12 DOTS entries:

    DT.441007  DT.316205  DT.75175404  DT.75177674  DT.120993364  DT.75109347  DT.95172240  DT.97840921 
    DT.100794262  DT.120993365  DT.92436282  DT.95172241 

    24/193 AceView cDNA sequences (see all 193):

    CR613970 AI478168 CB145792 AV714405 AI539479 AF523360 AW182412 AI222642 
    AU137755 AI560638 CD623418 AI373601 CD519643 AA358344 AA911198 AI963732 
    BX454585 T90964 BP372550 AA776300 BM804945 AW874505 AL540280 CB144093 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HNMT    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                    -     -     -           -                           
    SP2:        -                                                               
    SP3:                    -     -     -                                       
    SP4:                          -                                             
    SP5:                          -     -                                       


    ECgene alternative splicing isoforms for HNMT

    Expression
    for HNMT gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNMT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCCTTGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HNMT expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePeriportal HepatocytesLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See HNMT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNMT

    SOURCE GeneReport for Unigene cluster: Hs.42151
        SABiosciences Expression via Pathway-Focused PCR Arrays including HNMT: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    In Situ
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    Orthologs
    for HNMT gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HNMT gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hnmt1 , 5 histamine N-methyltransferase1, 5 86.76(n)1
    83.9(a)1    		   2 (16.06 cM)5
    1404831  NM_080462.21  NP_536710.11 
     240029105 
    chicken
    (Gallus gallus)    		 Aves HNMT1 histamine N-methyltransferase 67.58(n)
    60.14(a)    		   424298  XM_422143.3  XP_422143.2 
    lizard
    (Anolis carolinensis)    		 Reptilia HNMT6
    		 --
    		 66(a)
    		 1 ↔ 1
    		 1(98211530-98238673)
    African clawed frog
    (Xenopus laevis)    		 Amphibia hnmt-prov2 histamine N-methyltransferase 72.47(n)    BC054281.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.173402 Transcribed sequence with weak similarity to protein more 77.2(n)    CB360327.1 


    ENSEMBL Gene Tree for HNMT (if available)
    TreeFam Gene Tree for HNMT (if available) 

    Paralogs
    for HNMT gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for HNMT gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: HNMT_HUMAN, P50135
    Polymorphism: Variant Ile-105 has a reduced activity and seems to be linked with a predisposition to asthma


    10/958 NCBI SNPs in HNMT are shown (see all 958)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs115585381,2
    		C,F,other138759649(+) CAAGAC/TATCGA 2 T I mis125Minor allele frequency- T:0.07NS EA MN WA NA EU 9413
    rs1932152341,2
    		--138720044(+) GTGAAA/TCAAAA 3 -- us2k10--------
    rs1840749421,2
    		--138720274(+) CAAACC/TCAACC 3 -- us2k10--------
    rs31132011,2
    		C,F,A,H,--138720333(+) TTTTAA/TATGGT 3 -- us2k113Minor allele frequency- T:0.02NS EA NA WA CSA 668
    rs728603661,2
    		C,F,--138720409(+) ATGTCC/TGTGAA 3 -- us2k11Minor allele frequency- T:0.09NA 120
    rs1886582671,2
    		--138720410(+) TGTCCA/GTGAAT 3 -- us2k10--------
    rs64307641,2
    		C,F,A,H,--138720423(+) AGTGAT/CGACTG 3 -- us2k122Minor allele frequency- C:0.48NS EA NA WA CSA 2346
    rs1929596331,2
    		--138720452(+) TATATA/TTTTTT 3 -- us2k10--------
    rs1839217481,2
    		--138720454(+) TATATA/TTTTTT 3 -- us2k10--------
    rs1153727171,2
    		F,--138720476(+) TGGCTT/GGCACT 3 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for HNMT (138721590 - 138773934 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for HNMT
         2 CNVs: 97999 47913
    Human Gene Mutation Database (HGMD): HNMT

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HNMT
    DNA2.0 Custom Variant and Variant Library Synthesis for HNMT

    Disorders / Diseases
    for HNMT gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HNMT for disorders           About GeneDecksing

    OMIM gene information: 605238   
    OMIM disorders: 600807  
    20/42 diseases for HNMT (see all 42):    About MalaCards
    heel spur    eosinophilia-myalgia syndrome    allergic rhinitis    erythema multiforme
    food allergy    essential tremor    angioedema    prosopagnosia
    tremor    bronchial asthma    hearing loss    atopic dermatitis
    duodenal ulcer    rhinitis    urticaria    asthma
    down syndrome    eosinophilia    allergic asthma    pick's disease

    1 disease from the University of Copenhagen DISEASES database for HNMT:
    Cortical blindness

    8 Novoseek disease relationships for HNMT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nasal polyps 47.6 3 8448680 (2), 8838085 (1)
    urticaria 38.6 2 16825866 (1)
    asthma 37.3 14 10803682 (3), 16205835 (3), 15693910 (1), 17672811 (1) (see all 8)
    allergic rhinitis 33.7 3 10051705 (2), 19025430 (1)
    angioedema 31.8 2 16825866 (1)
    down syndrome 3.19 1 9148245 (1)
    alcoholism 0.0192 3 16950574 (1), 15770103 (1)
    alzheimers disease 0 1 16168438 (1)

    Genetic Association Database (GAD): HNMT
    Human Genome Epidemiology (HuGE) Navigator: HNMT (37 documents)

    Export disorders for HNMT gene to outside databases

    Publications
    for HNMT gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNMT gene, integrated from 9 sources (see all 133):
    (articles sorted by number of sources associating them with HNMT)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. (PubMed id 10803682)1, 2, 4, 9 Yan L....Weinshilboum R.M. (2000)
    2. Human histamine N-methyltransferase pharmacogenetics: cloning and expression of kidney cDNA. (PubMed id 8145732)1, 2, 9 Girard B....Weinshilboum R.M. (1994)
    3. Genotype-phenotype correlation for histamine N-methyltransferase in a Chinese Han population. (PubMed id 12867290)1, 4, 9 Chen G.L....Zhou H.H. (2003)
    4. Human histamine N-methyltransferase pharmacogenetics: gene resequencing, promoter characterization, and functional studies of a common 5'-flanking region single nucleotide polymorphism (SNP). (PubMed id 12167489)1, 4, 9 Wang L....Weinshilboum R. (2002)
    5. Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway. (PubMed id 7943261)1, 2, 9 Yamauchi K.... Takemura M. (1994)
    6. Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity. (PubMed id 9547362)1, 2, 9 Preuss C.V.... Weinshilboum R.M. (1998)
    7. Histamine N-methyltransferase gene polymorphisms in Chinese and their relationship with enzyme activity in erythrocytes. (PubMed id 12835614)1, 4, 9 Chen G.L....Zhou H.H. (2003)
    8. Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population. (PubMed id 16205835)1, 4, 9 Sharma S....Ghosh B. (2005)
    9. Human histamine N-methyltransferase gene: structural characterization and chromosomal location. (PubMed id 8605025)1, 2, 9 Aksoy S.... Weinshilboum R.M. (1996)
    10. Characterization of a new mRNA species from the human histamine N- methyltransferase gene. (PubMed id 14667820)1, 2, 9 Barnes W.G.... Hough L.B. (2004)

    External Searches for HNMT gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HNMT gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3176 HGNC: 5028 AceView: HNMT Ensembl:ENSG00000150540 euGenes: HUgn3176
    ECgene: HNMT Kegg: 3176 H-InvDB: HNMT

    Other Databases showing HNMT gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HNMT gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNMT Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HNMT gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HNMT gene:
    Search GeneIP for patents involving HNMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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