External Ids for HNMT Gene
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for HNMT Gene
HNMT (Histamine N-Methyltransferase) is a Protein Coding gene. Diseases associated with HNMT include asthma and eosinophilia-myalgia syndrome. Among its related pathways are Biological oxidations and Histidine metabolism. GO annotations related to this gene include histamine N-methyltransferase activity.
UniProtKB/Swiss-Prot for HNMT Gene
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine
Histamine N-methyltransferase (HMT) catalyzes the metabolism of histamine. It is ubiquitously expressed and the level of this enzyme is a critical factor in airway responsiveness to histamine.