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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNMT Gene

protein-coding   GIFtS: 65
GCID: GC02P138744

Histamine N-Methyltransferase

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histamine N-Methyltransferase1 2
HMT2 3
EC 2.1.1.83 8
HNMT-S12
HNMT-S22

External Ids:    HGNC: 50281   Entrez Gene: 31762   Ensembl: ENSG000001505407   OMIM: 6052385   UniProtKB: P501353   

Export aliases for HNMT gene to outside databases

Previous GC identifers: GC02P136386 GC02P137029 GC02P138932 GC02P138555 GC02P138438 GC02P130713


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HNMT Gene:
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase
and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol
and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of
histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A
common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple
alternatively spliced transcript variants that encode different proteins have been found for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for HNMT Gene: 
HNMT (histamine N-methyltransferase) is a protein-coding gene. Diseases associated with HNMT include asthma, and eosinophilia-myalgia syndrome, and among its related super-pathways are Biological oxidations. GO annotations related to this gene include histamine N-methyltransferase activity.

UniProtKB/Swiss-Prot: HNMT_HUMAN, P50135
Function: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating
the airway response to histamine

summary for HNMT Gene:
Histamine N-methyltransferase (HMT) catalyzes the metabolism of histamine. It is ubiquitously expressed and
the level of this enzyme is a critical factor in airway responsiveness to histamine.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNMT gene promoter:
         SRF   SRF (504 AA)   ATF-2   Cdc5   E47   POU2F1   POU2F1b   HFH-1   POU2F1a   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNMT promoter sequence
   Search SABiosciences Chromatin IP Primers for HNMT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q22.1   Ensembl cytogenetic band:  2q22.1   HGNC cytogenetic band: 2q22.1

HNMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNMT gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P138744:  view genomic region     (about GC identifiers)

Start:
138,721,590 bp from pter      End:
138,773,934 bp from pter
Size:
52,345 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HNMT_HUMAN, P50135 (See protein sequence)
Recommended Name: Histamine N-methyltransferase  
Size: 292 amino acids; 33295 Da
Subunit: Monomer
Subcellular location: Cytoplasm
6/8 PDB 3D structures from and Proteopedia for HNMT (see all 8):
1ICZ (3D)        1JQD (3D)        1JQE (3D)        2AOT (3D)        2AOU (3D)        2AOV (3D)    
Secondary accessions: B2R9J3 Q546Z6 Q7Z7I2 Q8IU56 Q8WW98 Q9BRW6
Alternative splicing: 3 isoforms:  P50135-1   P50135-2   P50135-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HNMT: NX_P50135

Explore proteomics data for HNMT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50135

  • 4/8 DME Specific Peptides for HNMT (P50135) (see all 8)
     DFLTETC  VEPSAEQI  LSIGGGAGE  WHKETSSEYQ 

    HNMT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HNMT Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001019245.1  NP_001019246.1  NP_008826.1  

    ENSEMBL proteins: 
     ENSP00000386940   ENSP00000333259   ENSP00000280097   ENSP00000280096   ENSP00000419415  

    Human Recombinant Protein Products for HNMT: 
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    Cloud-Clone Corp. Proteins for HNMT 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0043005neuron projection IEA--

    HNMT for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for HNMT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR016673 Histamine_N-methyltransferase

    Graphical View of Domain Structure for InterPro Entry P50135

    ProtoNet protein and cluster: P50135

    UniProtKB/Swiss-Prot: HNMT_HUMAN, P50135
    Similarity: Belongs to the methyltransferase superfamily. HNMT family


    HNMT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNMT_HUMAN, P50135
    Function: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating
    the airway response to histamine
    Catalytic activity: S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine

         Genatlas biochemistry entry for HNMT:
    histamine N-methyltransferase,S-adenosyl-L-methionine dependent cytosolic enzyme

         Enzyme Number (IUBMB): EC 2.1.1.81 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008170N-methyltransferase activity ----
    GO:0046539histamine N-methyltransferase activity IEA--
         
    HNMT for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HNMT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HNMT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HNMT 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HNMT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    metapathway biotransformation0.41
    2histamine degradation
    histamine degradation
    3Histidine metabolism
    Histidine metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for HNMT
        histamine degradation
    metapathway biotransformation



    1         Kegg Pathway  (Kegg details for HNMT):
        Histidine metabolism


    HNMT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HNMT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for HNMT (ENSP000002800974) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AOC1ENSP000003541934STRING: ENSP00000354193
    DDCENSP000003506164STRING: ENSP00000350616
    HDCENSP000002678454STRING: ENSP00000267845
    MAOAENSP000003406844STRING: ENSP00000340684
    MAOBENSP000003673094STRING: ENSP00000367309
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002347response to tumor cell IEA--
    GO:0006950response to stress ----
    GO:0006972hyperosmotic response IEA--
    GO:0007420brain development IEA--
    GO:0007585respiratory gaseous exchange TAS7943261

    HNMT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HNMT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HNMT available from Tocris Bioscience    About this table
    CompoundAction CAS #
    UNC 0638Selective G9a and GLP histone lysine methyltransferase inhibitor[1255517-77-1]
    BIX 01294G9a-like protein and G9a histone lysine methyltransferase inhibitor[935693-62-2]
    SGC 0946Highly potent and selective DOT1L inhibitor; cell permeable--
    3-Deazaneplanocin A hydrochlorideHistone methyltransferase inhibitor[120964-45-6]
    UNC 0646Potent and selective G9a/GLP inhibitor[1320288-17-2]

    4 HMDB Compounds for HNMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Methylhistamine1-Methyl-1H-imidazole-4-ethanamine (see all 21)501-75-7--
    Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    7 DrugBank Compounds for HNMT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AmodiaquineAmodiaquin (see all 4)86-42-0targetinhibitor17222819 1203620 6789797 11752352
    Histamine Phosphate-- 51-74-1enzymesubstrate19450133 8750789
    Quinacrine-- 83-89-6enzymeinhibitor12713826 3933141
    4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE-- --target--10592235
    ChlorhexidineChlorhexidin [Czech] (see all 4)55-56-1enzymeinhibitor3337739
    METOPRINE, METHODICHLOROPHEN-- --target--10592235
    S-Adenosyl-L-Homocysteine-- 979-92-0target----
    enzyme----

    10/16 Novoseek inferred chemical compound relationships for HNMT gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    histamine 86.8 349 7875186 (5), 11475331 (5), 7943261 (5), 19178400 (4) (see all 84)
    hydrazine 82.9 40 1588129 (1), 15054605 (1), 17562176 (1), 19899403 (1) (see all 21)
    aminoquinoline 73.6 2 11855993 (1), 12713826 (1)
    amodiaquine 57.1 3 1907425 (1), 16168438 (1), 8145732 (1)
    thiopurine 54.8 5 10331075 (2), 9667080 (2)
    toluene diisocyanate 51.4 6 1960592 (2), 8396495 (1)
    diphenhydramine 46.9 2 18789706 (1), 16168438 (1)
    histidine 46.4 13 9148245 (2), 1588129 (1), 1960592 (1), 8448680 (1) (see all 7)
    s-adenosylmethionine 45.4 8 11566133 (1), 11475331 (1), 8147263 (1), 8145732 (1)
    tacrine 38.4 9 15834447 (4), 16168438 (1)

    1 PharmGKB related drug/compound annotation for HNMT gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  

    Search CenterWatch for drugs/clinical trials and news about HNMT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HNMT gene (3 alternative transcripts): 
    NM_001024074.2  NM_001024075.1  NM_006895.2  

    Unigene Cluster for HNMT:

    Histamine N-methyltransferase
    Hs.42151  [show with all ESTs]
    Unigene Representative Sequence: NM_006895
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000410115 ENST00000329366(uc002tve.3) ENST00000280097(uc002tvf.3)
    ENST00000280096(uc002tvd.3) ENST00000475675 ENST00000467390 ENST00000485653
    ENST00000480534

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    hsa-miR-579 hsa-miR-100* hsa-miR-4311 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-134 hsa-miR-3129-5p hsa-miR-3074-3p
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    Additional mRNA sequence: 

    AF523356.1 AF523357.1 AF523358.1 AF523359.1 AF523360.1 AK301462.1 AK313804.1 BC005907.1 
    BC020677.1 D16224.1 U08092.1 

    12 DOTS entries:

    DT.441007  DT.316205  DT.75175404  DT.75177674  DT.120993364  DT.75109347  DT.95172240  DT.97840921 
    DT.100794262  DT.120993365  DT.92436282  DT.95172241 

    24/193 AceView cDNA sequences (see all 193):

    AI478168 AI539479 CB144093 AA776300 CR613970 BX454585 AI588946 AA911198 
    BM804945 AA358344 AF523360 AW182412 AU137755 BP372550 AV714405 CK820135 
    CD623418 AI963732 AI383716 AL540280 AW874505 CD519643 AI222642 AI373601 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HNMT    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                    -     -     -           -                           
    SP2:        -                                                               
    SP3:                    -     -     -                                       
    SP4:                          -                                             
    SP5:                          -     -                                       


    ECgene alternative splicing isoforms for HNMT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNMT expression in normal human tissues (normalized intensities)      HNMT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCTTGCA
    HNMT Expression
    About this image


    HNMT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             monocytes   
     
     Fibroblast (Uncategorized)
             Human Ovarian Fibroblasts (HOF)   
     
     Uncategorized (Uncategorized)
             PureStem Progenitor ES-154
     
     Ovary (Reproductive System)
             Human Ovarian Fibroblasts (HOF)   
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...

    See HNMT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNMT

    SOURCE GeneReport for Unigene cluster: Hs.42151
        SABiosciences Expression via Pathway-Focused PCR Arrays including HNMT: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HNMT gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnmt1 , 5 histamine N-methyltransferase1, 5 86.76(n)1
    83.9(a)1
      2 (16.06 cM)5
    1404831  NM_080462.21  NP_536710.11 
     240029105 
    chicken
    (Gallus gallus)
    Aves HNMT1 histamine N-methyltransferase 67.58(n)
    60.14(a)
      424298  XM_422143.3  XP_422143.2 
    lizard
    (Anolis carolinensis)
    Reptilia HNMT6
    --
    --
    57(a)
    37(a)
    1 ↔ 1
    possible ortholog
    1(98203548-98241017)
    1(98104180-98139176)
    African clawed frog
    (Xenopus laevis)
    Amphibia hnmt-prov2 histamine N-methyltransferase 72.47(n)    BC054281.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.173402 Transcribed sequence with weak similarity to protein more 77.2(n)    CB360327.1 


    ENSEMBL Gene Tree for HNMT (if available)
    TreeFam Gene Tree for HNMT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: HNMT_HUMAN, P50135
    Polymorphism: Variant Ile-105 has a reduced activity and seems to be linked with a predisposition to asthma


    10/1107 SNPs in HNMT are shown (see all 1107)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115585381,2
    C,Fother1138259248(+) CAAGAC/TATCGA 2 T I mis125Minor allele frequency- T:0.07NS EA MN WA NA EU 9413
    VAR_0102524
    ----see VAR_0102522 T I mis40--------
    rs1932152341,2
    --138219653(+) GTGAAA/TCAAAA 3 -- us2k10--------
    rs1840749421,2
    --138219883(+) CAAACC/TCAACC 3 -- us2k10--------
    rs31132011,2
    C,F,A,H--138219942(+) TTTTAA/TATGGT 3 -- us2k113Minor allele frequency- T:0.02NS EA NA WA CSA 668
    rs728603661,2
    C,F--138220018(+) ATGTCC/TGTGAA 3 -- us2k11Minor allele frequency- T:0.09NA 120
    rs1886582671,2
    --138220019(+) TGTCCA/GTGAAT 3 -- us2k10--------
    rs64307641,2
    C,F,A,H--138220032(+) AGTGAT/CGACTG 3 -- us2k122Minor allele frequency- C:0.48NS EA NA WA CSA 2346
    rs1929596331,2
    --138220061(+) TATATA/TTTTTT 3 -- us2k10--------
    rs1839217481,2
    --138220063(+) TATATA/TTTTTT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for HNMT (138721590 - 138773934 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HNMT:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2513921CNV Deletion19546169
    esv2671408CNV Deletion23128226
    nsv875161CNV Loss21882294
    nsv875160CNV Loss21882294
    esv34124CNV Loss18971310
    nsv875159CNV Gain21882294
    nsv7329OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): HNMT
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HNMT
    DNA2.0 Custom Variant and Variant Library Synthesis for HNMT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605238   
    OMIM disorders: 600807  
    20/39 diseases for HNMT (see all 39):    About MalaCards
    asthma    eosinophilia-myalgia syndrome    heel spur    prosopagnosia
    intestinal disease    food allergy    erythema multiforme    cortical blindness
    essential tremor    urticaria    angioedema    duodenal ulcer
    tremor    gastric ulcer    duodenitis    allergic rhinitis
    eosinophilia    allergic asthma    rhinitis    pick's disease

    1 disease from the University of Copenhagen DISEASES database for HNMT:
    Cortical blindness

    HNMT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for HNMT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nasal polyps 47.6 3 8448680 (2), 8838085 (1)
    urticaria 38.6 2 16825866 (1)
    asthma 37.3 14 10803682 (3), 16205835 (3), 15693910 (1), 17672811 (1) (see all 8)
    allergic rhinitis 33.7 3 10051705 (2), 19025430 (1)
    angioedema 31.8 2 16825866 (1)
    down syndrome 3.19 1 9148245 (1)
    alcoholism 0.0192 3 16950574 (1), 15770103 (1)
    alzheimers disease 0 1 16168438 (1)

    Genetic Association Database (GAD): HNMT
    Human Genome Epidemiology (HuGE) Navigator: HNMT (37 documents)

    Export disorders for HNMT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNMT gene, integrated from 9 sources (see all 136):
    (articles sorted by number of sources associating them with HNMT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. (PubMed id 10803682)1, 2, 4, 9 Yan L....Weinshilboum R.M. (2000)
    2. Human histamine N-methyltransferase pharmacogenetics: cloning and expression of kidney cDNA. (PubMed id 8145732)1, 2, 9 Girard B....Weinshilboum R.M. (1994)
    3. Genotype-phenotype correlation for histamine N-methyltransferase in a Chinese Han population. (PubMed id 12867290)1, 4, 9 Chen G.L....Zhou H.H. (2003)
    4. Human histamine N-methyltransferase pharmacogenetics: gene resequencing, promoter characterization, and functional studies of a common 5'-flanking region single nucleotide polymorphism (SNP). (PubMed id 12167489)1, 4, 9 Wang L....Weinshilboum R. (2002)
    5. Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway. (PubMed id 7943261)1, 2, 9 Yamauchi K.... Takemura M. (1994)
    6. Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria. (PubMed id 19178400)1, 4, 9 Kim S.H....Park H.S. (2009)
    7. Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity. (PubMed id 9547362)1, 2, 9 Preuss C.V.... Weinshilboum R.M. (1998)
    8. Histamine N-methyltransferase gene polymorphisms in Chinese and their relationship with enzyme activity in erythrocytes. (PubMed id 12835614)1, 4, 9 Chen G.L....Zhou H.H. (2003)
    9. Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population. (PubMed id 16205835)1, 4, 9 Sharma S....Ghosh B. (2005)
    10. Human histamine N-methyltransferase gene: structural characterization and chromosomal location. (PubMed id 8605025)1, 2, 9 Aksoy S.... Weinshilboum R.M. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3176 HGNC: 5028 AceView: HNMT Ensembl:ENSG00000150540 euGenes: HUgn3176
    ECgene: HNMT Kegg: 3176 H-InvDB: HNMT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNMT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HNMT gene:
    Search GeneIP for patents involving HNMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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