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HNMT Gene

protein-coding   GIFtS: 64
GCID: GC02P138744

Histamine N-Methyltransferase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histamine N-Methyltransferase1 2
HMT2 3
EC 2.1.1.83 8
HNMT-S12
HNMT-S22

External Ids:    HGNC: 50281   Entrez Gene: 31762   Ensembl: ENSG000001505407   OMIM: 6052385   UniProtKB: P501353   

Export aliases for HNMT gene to outside databases

Previous GC identifers: GC02P136386 GC02P137029 GC02P138932 GC02P138555 GC02P138438 GC02P130713


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HNMT Gene:
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase
and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol
and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of
histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A
common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple
alternatively spliced transcript variants that encode different proteins have been found for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for HNMT Gene:
HNMT (histamine N-methyltransferase) is a protein-coding gene. Diseases associated with HNMT include heel spur, and prosopagnosia. GO annotations related to this gene include histamine N-methyltransferase activity.

UniProtKB/Swiss-Prot: HNMT_HUMAN, P50135
Function: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating
the airway response to histamine

summary for HNMT Gene:
Histamine N-methyltransferase (HMT) catalyzes the metabolism of histamine. It is ubiquitously expressed and
the level of this enzyme is a critical factor in airway responsiveness to histamine.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HNMT gene promoter:
         SRF   SRF (504 AA)   ATF-2   Cdc5   E47   POU2F1   POU2F1b   HFH-1   POU2F1a   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNMT promoter sequence
   Search Chromatin IP Primers for HNMT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HNMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q22.1   Ensembl cytogenetic band:  2q22.1   HGNC cytogenetic band: 2q22.1

HNMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNMT gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P138744:  view genomic region     (about GC identifiers)

Start:
138,721,590 bp from pter      End:
138,773,934 bp from pter
Size:
52,345 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HNMT_HUMAN, P50135 (See protein sequence)
Recommended Name: Histamine N-methyltransferase  
Size: 292 amino acids; 33295 Da
Subunit: Monomer
Selected PDB 3D structures from and Proteopedia for HNMT (see all 8):
1ICZ (3D)        1JQD (3D)        1JQE (3D)        2AOT (3D)        2AOU (3D)        2AOV (3D)    
Secondary accessions: B2R9J3 Q546Z6 Q7Z7I2 Q8IU56 Q8WW98 Q9BRW6
Alternative splicing: 3 isoforms:  P50135-1   P50135-2   P50135-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HNMT: NX_P50135

Explore proteomics data for HNMT at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HNMT (P50135) (see all 8)
     DFLTETC  VEPSAEQI  LSIGGGAGE  WHKETSSEYQ 


    See HNMT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001019245.1  NP_001019246.1  NP_008826.1  

    ENSEMBL proteins: 
     ENSP00000386940   ENSP00000333259   ENSP00000280097   ENSP00000280096   ENSP00000419415  

    HNMT Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for HNMT (Histamine N-Methyltransferase/HNMT)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HNMT
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HNMT
    GenScript Custom Purified and Recombinant Proteins Services for HNMT
    Novus Biologicals HNMT Proteins
    Novus Biologicals HNMT Lysates
    Sino Biological Recombinant Protein for HNMT
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HNMT
    Cloud-Clone Corp. Proteins for HNMT

    HNMT Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HNMT (Histamine N-Methyltransferase/HNMT)
    OriGene Antibodies for HNMT
    OriGene Custom Antibody Services for HNMT
    Novus Biologicals HNMT Antibodies
    Abcam antibodies for HNMT
    Cloud-Clone Corp. Antibodies for HNMT
    ThermoFisher Antibodies for HNMT
    LSBio Antibodies in human, mouse, rat for HNMT

    HNMT Assay Products:

    EMD Millipore Kits and Assays for the Analysis of HNMT
    OriGene Custom Assay Services for HNMT
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HNMT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HNMT
    Cloud-Clone Corp. CLIAs for HNMT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR016673 Histamine_N-methyltransferase

    Graphical View of Domain Structure for InterPro Entry P50135

    ProtoNet protein and cluster: P50135

    UniProtKB/Swiss-Prot: HNMT_HUMAN, P50135
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family


    HNMT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNMT_HUMAN, P50135
    Function: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating
    the airway response to histamine
    Catalytic activity: S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine

         Genatlas biochemistry entry for HNMT:
    histamine N-methyltransferase,S-adenosyl-L-methionine dependent cytosolic enzyme

         Enzyme Number (IUBMB): EC 2.1.1.81 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008170N-methyltransferase activity ----
    GO:0046539histamine N-methyltransferase activity IEA--
         
    HNMT for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HNMT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HNMT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HNMT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HNMT

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HNMT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HNMT (see all 23):
    hsa-miR-579 hsa-miR-100* hsa-miR-4311 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-134 hsa-miR-3129-5p hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmidHNMT 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HNMT
    Predesigned siRNA for gene silencing in human, mouse, rat HNMT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HNMT

    Clone
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    OriGene clones in human, mouse for HNMT (see all 18)
    OriGene ORF clones in mouse, rat for HNMT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): HNMT (NM_001024074)
    Sino Biological Human cDNA Clone for HNMT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNMT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNMT

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HNMT
    Browse ESI BIO Cell Lines and PureStem Progenitors for HNMT 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNMT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HNMT_HUMAN, P50135: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0043005neuron projection IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    HNMT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HNMT About    
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    metapathway biotransformation0.42
    2Histidine metabolism
    Histidine metabolism
    3histamine degradation
    histamine degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for HNMT
        histamine degradation
    metapathway biotransformation



    1 Kegg Pathway  (Kegg details for HNMT):
        Histidine metabolism


    HNMT for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HNMT: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HNMT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for HNMT (ENSP000002800974) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AOC1ENSP000003541934STRING: ENSP00000354193
    DDCENSP000003506164STRING: ENSP00000350616
    HDCENSP000002678454STRING: ENSP00000267845
    MAOAENSP000003406844STRING: ENSP00000340684
    MAOBENSP000003673094STRING: ENSP00000367309
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002347response to tumor cell IEA--
    GO:0006972hyperosmotic response IEA--
    GO:0007420brain development IEA--
    GO:0007585respiratory gaseous exchange TAS7943261
    GO:0014075response to amine IEA--

    HNMT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for HNMT (see all 15)     About this table
    CompoundAction CAS #
    3-Deazaneplanocin,DZNepBlocks EZH2 activity and trimethylation of lysine 27 on histone H3 in vitro[102052-95-9]
    AZ505potent and highly selective inhibitor of the oncogenic protein SMYD2[1035227-43-0]
    BIX 01294BIX-01294 is a small molecule inhibitor of G9a and GLP[935693-62-2]
    ChaetocinHistone methyltransferase SUV39H1 inhibitor[28097-03-2]
    EntacaponeEntacapone inhibits catechol-O-methyltransferase(COMT)[130929-57-6]
    EPZ-6438potent and bio-available inhibitor of EZH2[1403254-99-8 ]
    EPZ004777potent, selective DOT1L inhibitor[1338466-77-5]
    EPZ005687potent inhibitor of EZH2[1396772-26-1]
    EPZ5676potent inhibitor of DOT1L histone methyltransferase[1380288-87-8]
    SGC 0946highly potent and selective DOT1 Lmethyltransferase inhibitor--

    Compounds for HNMT available from Tocris Bioscience    About this table
    CompoundAction CAS #
    UNC 0638Selective G9a and GLP histone lysine methyltransferase inhibitor[1255517-77-1]
    BIX 01294G9a-like protein and G9a histone lysine methyltransferase inhibitor[935693-62-2]
    SGC 0946Highly potent and selective DOT1L inhibitor; cell permeable--
    3-Deazaneplanocin A hydrochlorideHistone methyltransferase inhibitor[120964-45-6]
    UNC 0646Potent and selective G9a/GLP inhibitor[1320288-17-2]

    4 HMDB Compounds for HNMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Methylhistamine1-Methyl-1H-imidazole-4-ethanamine (see all 21)501-75-7--
    Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    7 DrugBank Compounds for HNMT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AmodiaquineAmodiaquin (see all 4)86-42-0targetinhibitor17222819 1203620 6789797 11752352
    Histamine Phosphate-- 51-74-1enzymesubstrate19450133 8750789
    Quinacrine-- 83-89-6enzymeinhibitor12713826 3933141
    4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE-- --target--10592235
    ChlorhexidineChlorhexidin [Czech] (see all 4)55-56-1enzymeinhibitor3337739
    METOPRINE, METHODICHLOROPHEN-- --target--10592235
    S-Adenosyl-L-Homocysteine-- 979-92-0target----
    enzyme----

    Selected Novoseek inferred chemical compound relationships for HNMT gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    histamine 86.8 349 7875186 (5), 11475331 (5), 7943261 (5), 19178400 (4) (see all 84)
    hydrazine 82.9 40 1588129 (1), 15054605 (1), 17562176 (1), 19899403 (1) (see all 21)
    aminoquinoline 73.6 2 11855993 (1), 12713826 (1)
    amodiaquine 57.1 3 1907425 (1), 16168438 (1), 8145732 (1)
    thiopurine 54.8 5 10331075 (2), 9667080 (2)
    toluene diisocyanate 51.4 6 1960592 (2), 8396495 (1)
    diphenhydramine 46.9 2 18789706 (1), 16168438 (1)
    histidine 46.4 13 9148245 (2), 1588129 (1), 1960592 (1), 8448680 (1) (see all 7)
    s-adenosylmethionine 45.4 8 11566133 (1), 11475331 (1), 8147263 (1), 8145732 (1)
    tacrine 38.4 9 15834447 (4), 16168438 (1)

    1 PharmGKB related drug/compound annotation for HNMT gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  



    HNMT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HNMT gene (3 alternative transcripts): 
    NM_001024074.2  NM_001024075.1  NM_006895.2  

    Unigene Cluster for HNMT:

    Histamine N-methyltransferase
    Hs.42151  [show with all ESTs]
    Unigene Representative Sequence: NM_006895
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000410115 ENST00000329366(uc002tve.3) ENST00000280097(uc002tvf.3)
    ENST00000280096(uc002tvd.3) ENST00000475675 ENST00000467390 ENST00000485653
    ENST00000480534

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HNMT (see all 23):
    hsa-miR-579 hsa-miR-100* hsa-miR-4311 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-134 hsa-miR-3129-5p hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmidHNMT 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HNMT
    Predesigned siRNA for gene silencing in human, mouse, rat HNMT
    Clone
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    OriGene clones in human, mouse for HNMT (see all 18)
    OriGene ORF clones in mouse, rat for HNMT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): HNMT (NM_001024074)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNMT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNMT
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HNMT
    OriGene qSTAR qPCR primer pairs in human, mouse for HNMT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HNMT
      QuantiTect SYBR Green Assays in human, mouse, rat HNMT
      QuantiFast Probe-based Assays in human, mouse, rat HNMT

    Additional mRNA sequence: 

    AF523356.1 AF523357.1 AF523358.1 AF523359.1 AF523360.1 AK301462.1 AK313804.1 BC005907.1 
    BC020677.1 D16224.1 U08092.1 

    12 DOTS entries:

    DT.441007  DT.316205  DT.75175404  DT.75177674  DT.120993364  DT.75109347  DT.95172240  DT.97840921 
    DT.100794262  DT.120993365  DT.92436282  DT.95172241 

    Selected AceView cDNA sequences (see all 193):

    AI373601 AW182412 CK820135 CD519643 CB145792 BM804945 AI539479 CD623418 
    AI588946 AV714405 AF523360 AI478168 AI383716 AA776300 AW874505 AL540280 
    CR613970 BP372550 AA911198 BX454585 AA953214 AF523359 T90964 AI222642 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HNMT    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                    -     -     -           -                           
    SP2:        -                                                               
    SP3:                    -     -     -                                       
    SP4:                          -                                             
    SP5:                          -     -                                       


    ECgene alternative splicing isoforms for HNMT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HNMT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCTTGCA
    HNMT Expression
    About this image


    HNMT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Brain (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus
     
     Colon (Gastrointestinal Tract)
    HNMT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HNMT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.42151
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HNMT: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HNMT
    OriGene qSTAR qPCR primer pairs in human, mouse for HNMT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HNMT
    QuantiTect SYBR Green Assays in human, mouse, rat HNMT
    QuantiFast Probe-based Assays in human, mouse, rat HNMT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNMT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for HNMT gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hnmt1 , 5 histamine N-methyltransferase1, 5 86.76(n)1
    83.9(a)1
      2 (16.06 cM)5
    1404831  NM_080462.21  NP_536710.11 
     240029105 
    chicken
    (Gallus gallus)
    Aves HNMT1 histamine N-methyltransferase 67.58(n)
    60.14(a)
      424298  NM_001277873.1  NP_001264802.1 
    lizard
    (Anolis carolinensis)
    Reptilia HNMT6
    histamine N-methyltransferase
    57(a)
    1 ↔ 1
    1(98203548-98241017)
    African clawed frog
    (Xenopus laevis)
    Amphibia hnmt-prov2 histamine N-methyltransferase 72.47(n)    BC054281.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.173402 Transcribed sequence with weak similarity to protein more 77.2(n)    CB360327.1 


    ENSEMBL Gene Tree for HNMT (if available)
    TreeFam Gene Tree for HNMT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Polymorphic Variants from UniProtKB/Swiss-Prot
    HNMT_HUMAN, P50135: Variant Ile-105 has a reduced activity and seems to be linked with a predisposition to asthma


    Selected SNPs for HNMT (see all 1107)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115585381,2
    C,Fother1138259248(+) CAAGAC/TATCGA 2 T I mis125Minor allele frequency- T:0.07NS EA MN WA NA EU 9413
    rs1932152341,2
    --138219653(+) GTGAAA/TCAAAA 3 -- us2k10--------
    rs1840749421,2
    --138219883(+) CAAACC/TCAACC 3 -- us2k10--------
    rs31132011,2
    C,F,A,H--138219942(+) TTTTAA/TATGGT 3 -- us2k113Minor allele frequency- T:0.02NS EA NA WA CSA 668
    rs728603661,2
    C,F--138220018(+) ATGTCC/TGTGAA 3 -- us2k11Minor allele frequency- T:0.09NA 120
    rs1886582671,2
    --138220019(+) TGTCCA/GTGAAT 3 -- us2k10--------
    rs64307641,2
    C,F,A,H--138220032(+) AGTGAT/CGACTG 3 -- us2k122Minor allele frequency- C:0.48NS EA NA WA CSA 2346
    rs1929596331,2
    --138220061(+) TATATA/TTTTTT 3 -- us2k10--------
    rs1839217481,2
    --138220063(+) TATATA/TTTTTT 3 -- us2k10--------
    rs1153727171,2
    F--138220085(+) TGGCTT/GGCACT 3 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for HNMT (138721590 - 138773934 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HNMT:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2513921CNV Deletion19546169
    esv2671408CNV Deletion23128226
    nsv875161CNV Loss21882294
    nsv875160CNV Loss21882294
    esv34124CNV Loss18971310
    nsv875159CNV Gain21882294
    nsv7329OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): HNMT
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HNMT
    DNA2.0 Custom Variant and Variant Library Synthesis for HNMT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605238   
    OMIM disorders: 600807  
    Selected diseases for HNMT (see all 39):    
    About MalaCards
    heel spur    prosopagnosia    eosinophilia-myalgia syndrome    intestinal disease
    asthma    erythema multiforme    cortical blindness    essential tremor
    urticaria    angioedema    food allergy    tremor
    duodenal ulcer    gastric ulcer    duodenitis    eosinophilia
    allergic rhinitis    rhinitis    pick's disease    allergic asthma

    1 disease from the University of Copenhagen DISEASES database for HNMT:
    Cortical blindness

    HNMT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for HNMT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nasal polyps 47.6 3 8448680 (2), 8838085 (1)
    urticaria 38.6 2 16825866 (1)
    asthma 37.3 14 10803682 (3), 16205835 (3), 15693910 (1), 17672811 (1) (see all 8)
    allergic rhinitis 33.7 3 10051705 (2), 19025430 (1)
    angioedema 31.8 2 16825866 (1)
    down syndrome 3.19 1 9148245 (1)
    alcoholism 0.0192 3 16950574 (1), 15770103 (1)
    alzheimers disease 0 1 16168438 (1)

    Genetic Association Database (GAD): HNMT
    Human Genome Epidemiology (HuGE) Navigator: HNMT (37 documents)

    Export disorders for HNMT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for HNMT gene, integrated from 10 sources (see all 137):
    (articles sorted by number of sources associating them with HNMT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. (PubMed id 10803682)1, 2, 4, 9 Yan L....Weinshilboum R.M. (Pharmacogenetics 2000)
    2. Human histamine N-methyltransferase pharmacogenetics: cloning and expression of kidney cDNA. (PubMed id 8145732)1, 2, 9 Girard B....Weinshilboum R.M. (Mol. Pharmacol. 1994)
    3. Genotype-phenotype correlation for histamine N-methyltransferase in a Chinese Han population. (PubMed id 12867290)1, 4, 9 Chen G.L....Zhou H.H. ( international journal of clinical chemistry 2003)
    4. Human histamine N-methyltransferase pharmacogenetics: gene resequencing, promoter characterization, and functional studies of a common 5'-flanking region single nucleotide polymorphism (SNP). (PubMed id 12167489)1, 4, 9 Wang L....Weinshilboum R. (Biochem. Pharmacol. 2002)
    5. Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway. (PubMed id 7943261)1, 2, 9 Yamauchi K.... Takemura M. (Am. J. Physiol. 1994)
    6. Histamine N-methyltransferase 939A&gt;G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria. (PubMed id 19178400)1, 4, 9 Kim S.H....Park H.S. (Allergy 2009)
    7. Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity. (PubMed id 9547362)1, 2, 9 Preuss C.V.... Weinshilboum R.M. (Mol. Pharmacol. 1998)
    8. Histamine N-methyltransferase gene polymorphisms in Chinese and their relationship with enzyme activity in erythrocytes. (PubMed id 12835614)1, 4, 9 Chen G.L....Zhou H.H. (Pharmacogenetics 2003)
    9. Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population. (PubMed id 16205835)1, 4, 9 Sharma S....Ghosh B. (J. Hum. Genet. 2005)
    10. Human histamine N-methyltransferase gene: structural characterization and chromosomal location. (PubMed id 8605025)1, 2, 9 Aksoy S.... Weinshilboum R.M. (Biochem. Biophys. Res. Commun. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3176 HGNC: 5028 AceView: HNMT Ensembl:ENSG00000150540 euGenes: HUgn3176
    ECgene: HNMT Kegg: 3176 H-InvDB: HNMT

    (According to HUGE)
    About This Section

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HNMT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HNMT gene:
    Search GeneIP for patents involving HNMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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