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Aliases for HNF4G Gene

Aliases for HNF4G Gene

  • Hepatocyte Nuclear Factor 4 Gamma 2 3
  • Nuclear Receptor Subfamily 2 Group A Member 2 3 4
  • Hepatocyte Nuclear Factor 4, Gamma 3 5
  • HNF-4-Gamma 3 4
  • NR2A2 3 4
  • NR2A3 3

External Ids for HNF4G Gene

Previous GeneCards Identifiers for HNF4G Gene

  • GC08P075350
  • GC08P076308
  • GC08P076043
  • GC08P076370
  • GC08P076502
  • GC08P076482
  • GC08P076614
  • GC08P071939

Summaries for HNF4G Gene

GeneCards Summary for HNF4G Gene

HNF4G (Hepatocyte Nuclear Factor 4 Gamma) is a Protein Coding gene. Diseases associated with HNF4G include Maturity-Onset Diabetes Of The Young. Among its related pathways are Gene Expression and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and steroid hormone receptor activity. An important paralog of this gene is RXRG.

UniProtKB/Swiss-Prot for HNF4G Gene

  • Transcription factor. Has a lower transcription activation potential than HNF4-alpha.

Gene Wiki entry for HNF4G Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNF4G Gene

Genomics for HNF4G Gene

Regulatory Elements for HNF4G Gene

Enhancers for HNF4G Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HNF4G on UCSC Golden Path with GeneCards custom track

Promoters for HNF4G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HNF4G on UCSC Golden Path with GeneCards custom track

Genomic Location for HNF4G Gene

Chromosome:
8
Start:
75,407,681 bp from pter
End:
75,566,843 bp from pter
Size:
159,163 bases
Orientation:
Plus strand

Genomic View for HNF4G Gene

Genes around HNF4G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNF4G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNF4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNF4G Gene

Proteins for HNF4G Gene

  • Protein details for HNF4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14541-HNF4G_HUMAN
    Recommended name:
    Hepatocyte nuclear factor 4-gamma
    Protein Accession:
    Q14541
    Secondary Accessions:
    • Q7Z2V9
    • Q9UH81
    • Q9UIS6

    Protein attributes for HNF4G Gene

    Size:
    408 amino acids
    Molecular mass:
    45877 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAE11875.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNF4G Gene

    Alternative splice isoforms for HNF4G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNF4G Gene

Proteomics data for HNF4G Gene at MOPED

Post-translational modifications for HNF4G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HNF4G Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HNF4G (HNF-4 gamma/NR2A2)

No data available for DME Specific Peptides for HNF4G Gene

Domains & Families for HNF4G Gene

Gene Families for HNF4G Gene

Graphical View of Domain Structure for InterPro Entry

Q14541

UniProtKB/Swiss-Prot:

HNF4G_HUMAN :
  • Contains 1 nuclear receptor DNA-binding domain.
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with HNF4G: view

Function for HNF4G Gene

Molecular function for HNF4G Gene

GENATLAS Biochemistry:
hepatocyte nuclear factor 4 gamma,steroid/thyroid receptor superfamily,expressed in kidney,pancreas,small intestine,testis,colon,not in the liver,involved in differential transcriptional regulation,not playing a major role in the etiology of early onst autosomal dominant,non insulin dependent type 2,diabetes
UniProtKB/Swiss-Prot Function:
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.

Gene Ontology (GO) - Molecular Function for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IEA --
GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HNF4G: view
genes like me logo Genes that share phenotypes with HNF4G: view

Animal Models for HNF4G Gene

MGI Knock Outs for HNF4G:

Animal Model Products

  • Taconic Biosciences Mouse Models for HNF4G

miRNA for HNF4G Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HNF4G Gene

Localization for HNF4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNF4G Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNF4G Gene COMPARTMENTS Subcellular localization image for HNF4G gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HNF4G Gene

Pathways & Interactions for HNF4G Gene

genes like me logo Genes that share pathways with HNF4G: view

Pathways by source for HNF4G Gene

Gene Ontology (GO) - Biological Process for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0031018 endocrine pancreas development TAS --
genes like me logo Genes that share ontologies with HNF4G: view

No data available for SIGNOR curated interactions for HNF4G Gene

Drugs & Compounds for HNF4G Gene

(1) Drugs for HNF4G Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Experimental Pharma Full agonist, Agonist, Target 22
genes like me logo Genes that share compounds with HNF4G: view

Transcripts for HNF4G Gene

Unigene Clusters for HNF4G Gene

Hepatocyte nuclear factor 4, gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNF4G Gene

No ASD Table

Relevant External Links for HNF4G Gene

GeneLoc Exon Structure for
HNF4G
ECgene alternative splicing isoforms for
HNF4G

Expression for HNF4G Gene

mRNA expression in normal human tissues for HNF4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HNF4G Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x19.9), Colon - Transverse (x10.9), and Liver (x5.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNF4G Gene



SOURCE GeneReport for Unigene cluster for HNF4G Gene Hs.241529

mRNA Expression by UniProt/SwissProt for HNF4G Gene

Q14541-HNF4G_HUMAN
Tissue specificity: Expressed in pancreas, kidney, small intestine and testis. Weakly expressed in colon. Not expressed in liver, skeletal muscle, lung, placenta, brain, heart, peripheral blood, ovary, prostate, thymus and spleen.
genes like me logo Genes that share expression patterns with HNF4G: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for HNF4G Gene

Orthologs for HNF4G Gene

This gene was present in the common ancestor of animals.

Orthologs for HNF4G Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HNF4G 35
  • 92.06 (n)
  • 96.23 (a)
HNF4G 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNF4G 35
  • 92.88 (n)
  • 96.85 (a)
HNF4G 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnf4g 35
  • 87.02 (n)
  • 95.91 (a)
Hnf4g 16
Hnf4g 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HNF4G 35
  • 99.7 (n)
  • 99.78 (a)
HNF4G 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnf4g 35
  • 86.7 (n)
  • 94.95 (a)
oppossum
(Monodelphis domestica)
Mammalia HNF4G 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNF4G 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNF4G 35
  • 80.93 (n)
  • 87.16 (a)
HNF4G 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNF4G 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnf4g 35
  • 74.74 (n)
  • 83.94 (a)
zebrafish
(Danio rerio)
Actinopterygii hnf4g 35
  • 65.13 (n)
  • 69.59 (a)
hnf4g 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hnf4 37
  • 66 (a)
Hnf4 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhr-14 37
  • 32 (a)
nhr-64 37
  • 42 (a)
nhr-69 37
  • 38 (a)
nhr-64 35
  • 48.89 (n)
  • 44.24 (a)
nhr-35 36
  • 25 (a)
ManyToMany
nhr-64 36
  • 40 (a)
ManyToMany
nhr-69 36
  • 38 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3727 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for HNF4G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNF4G Gene

ENSEMBL:
Gene Tree for HNF4G (if available)
TreeFam:
Gene Tree for HNF4G (if available)

Paralogs for HNF4G Gene

Paralogs for HNF4G Gene

Pseudogenes.org Pseudogenes for HNF4G Gene

genes like me logo Genes that share paralogs with HNF4G: view

Variants for HNF4G Gene

Sequence variations from dbSNP and Humsavar for HNF4G Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1805098 - 75,556,047(+) ATGAT(A/G)TATAA reference, missense
rs2037095 -- 75,477,111(+) ACCTT(C/T)AGCAG intron-variant
rs2056088 -- 75,458,767(-) GTATT(C/T)TTAAC intron-variant
rs2056089 -- 75,458,633(-) AACAA(A/C)GACAT intron-variant
rs2056090 -- 75,550,162(-) AGCAA(C/T)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNF4G Gene

Variant ID Type Subtype PubMed ID
dgv7807n71 CNV Loss 21882294
nsv831357 CNV Loss 17160897
nsv891028 CNV Gain 21882294
dgv7808n71 CNV Loss 21882294
nsv465718 CNV Loss 19166990
nsv465719 CNV Loss 19166990

Variation tolerance for HNF4G Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HNF4G Gene

Disorders for HNF4G Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNF4G Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
maturity-onset diabetes of the young
  • mason-type diabetes
- elite association - COSMIC cancer census association via MalaCards
Search HNF4G in MalaCards View complete list of genes associated with diseases

Relevant External Links for HNF4G

Genetic Association Database (GAD)
HNF4G
Human Genome Epidemiology (HuGE) Navigator
HNF4G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNF4G
genes like me logo Genes that share disorders with HNF4G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNF4G Gene

Publications for HNF4G Gene

  1. Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. (PMID: 12220494) Wisely G.B. … Williams S.P. (Structure 2002) 2 3 4 67
  2. Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers. (PMID: 12544512) Ozeki T. … Kamataki T. (Pharmacogenetics 2003) 3 23
  3. Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. (PMID: 10512380) Plengvidhya N. … Doria A. (Diabetes 1999) 3 23
  4. Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes. (PMID: 8622695) Drewes T. … Ryffel G.U. (Mol. Cell. Biol. 1996) 2 3
  5. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) KAPttgen A. … Gieger C. (Nat. Genet. 2013) 3

Products for HNF4G Gene

Sources for HNF4G Gene

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