Free for academic non-profit institutions. Other users need a Commercial license

HNF4G Gene(Protein Coding)

Hepatocyte Nuclear Factor 4 Gamma

GCID:
GC08P075407
GIFtS:
60
Genes Participants
UDN Logo

Aliases for HNF4G Gene

Aliases for HNF4G Gene

  • Hepatocyte Nuclear Factor 4 Gamma 2 3 5
  • Nuclear Receptor Subfamily 2 Group A Member 2 3 4
  • HNF-4-Gamma 3 4
  • NR2A2 3 4
  • Hepatocyte Nuclear Factor 4-Gamma 3
  • NR2A3 3

External Ids for HNF4G Gene

Previous GeneCards Identifiers for HNF4G Gene

  • GC08P075350
  • GC08P076308
  • GC08P076043
  • GC08P076370
  • GC08P076502
  • GC08P076482
  • GC08P076614
  • GC08P071939

Summaries for HNF4G Gene

GeneCards Summary for HNF4G Gene

HNF4G (Hepatocyte Nuclear Factor 4 Gamma) is a Protein Coding gene. Diseases associated with HNF4G include Maturity-Onset Diabetes Of The Young. Among its related pathways are Regulation of beta-cell development and Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and steroid hormone receptor activity. An important paralog of this gene is HNF4A.

UniProtKB/Swiss-Prot for HNF4G Gene

  • Transcription factor. Has a lower transcription activation potential than HNF4-alpha.

Gene Wiki entry for HNF4G Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNF4G Gene

Genomics for HNF4G Gene

Products:

  1. Regulatory Element

Regulatory Elements for HNF4G Gene

Enhancers for HNF4G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G075402 1.6 FANTOM5 ENCODE dbSUPER 7.2 +0.2 206 11.5 HDGF HNRNPUL1 FOXA2 MLX ARID4B DMAP1 ZNF2 YY1 SLC30A9 ZNF143 HNF4G GC08M075436
GH08G075418 1 ENCODE dbSUPER 5.2 +13.2 13202 4.9 JUN MAX ZNF316 GATA3 FOS MAFK FOXA3 MAFG DPF2 ATF2 HNF4G GC08M075436
GH08G075538 0.7 ENCODE 4.2 +133.5 133474 5.3 CTCF FOXA2 CBFB ZNF133 ZNF384 RAD21 TEAD3 RAD51 EED MLLT1 HNF4G GC08M075604 GC08P075474
GH08G075552 0.6 ENCODE 4.2 +146.2 146225 3.2 HDGF JUND IKZF1 CEBPB NR3C1 TBX21 HNF4G GC08M075604 GC08P075474
GH08G075425 0.5 ENCODE dbSUPER 4.5 +19.4 19387 2.8 HNF4G GC08M075436
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HNF4G on UCSC Golden Path with GeneCards custom track

Promoters for HNF4G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000226008 119 1201 HNRNPUL1 FOXA2 MLX ARID4B DMAP1 ZNF2 ZNF48 YY1 SLC30A9 GLIS2

Transcription factor binding sites by QIAGEN in the HNF4G gene promoter:

Genomic Location for HNF4G Gene

Chromosome:
8
Start:
75,407,681 bp from pter
End:
75,566,843 bp from pter
Size:
159,163 bases
Orientation:
Plus strand

Genomic View for HNF4G Gene

Genes around HNF4G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNF4G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNF4G Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HNF4G Gene

Proteins for HNF4G Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HNF4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14541-HNF4G_HUMAN
    Recommended name:
    Hepatocyte nuclear factor 4-gamma
    Protein Accession:
    Q14541
    Secondary Accessions:
    • Q7Z2V9
    • Q9UH81
    • Q9UIS6

    Protein attributes for HNF4G Gene

    Size:
    408 amino acids
    Molecular mass:
    45877 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAE11875.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNF4G Gene

    Alternative splice isoforms for HNF4G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNF4G Gene

Protein Expression for HNF4G Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HNF4G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HNF4G Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HNF4G (HNF-4 gamma/NR2A2)

No data available for DME Specific Peptides for HNF4G Gene

Domains & Families for HNF4G Gene

Gene Families for HNF4G Gene

HGNC:
IUPHAR :

Protein Domains for HNF4G Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HNF4G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14541

UniProtKB/Swiss-Prot:

HNF4G_HUMAN :
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with HNF4G: view

Function for HNF4G Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for HNF4G Gene

GENATLAS Biochemistry:
hepatocyte nuclear factor 4 gamma,steroid/thyroid receptor superfamily,expressed in kidney,pancreas,small intestine,testis,colon,not in the liver,involved in differential transcriptional regulation,not playing a major role in the etiology of early onst autosomal dominant,non insulin dependent type 2,diabetes
UniProtKB/Swiss-Prot Function:
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.

Gene Ontology (GO) - Molecular Function for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 12220531
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IC --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 8622695
GO:0003707 steroid hormone receptor activity IEA --
genes like me logo Genes that share ontologies with HNF4G: view
genes like me logo Genes that share phenotypes with HNF4G: view

Animal Models for HNF4G Gene

MGI Knock Outs for HNF4G:

Animal Model Products

  • Taconic Biosciences Mouse Models for HNF4G

CRISPR Products

miRNA for HNF4G Gene

miRTarBase miRNAs that target HNF4G

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HNF4G Gene

Localization for HNF4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNF4G Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNF4G gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HNF4G: view

Pathways & Interactions for HNF4G Gene

genes like me logo Genes that share pathways with HNF4G: view

Pathways by source for HNF4G Gene

1 KEGG pathway for HNF4G Gene
1 R&D Systems pathway for HNF4G Gene

Gene Ontology (GO) - Biological Process for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8622695
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0030522 intracellular receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with HNF4G: view

No data available for SIGNOR curated interactions for HNF4G Gene

Drugs & Compounds for HNF4G Gene

Products:

  1. Drug

(1) Drugs for HNF4G Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Experimental Pharma Full agonist, Agonist, Target 22
genes like me logo Genes that share compounds with HNF4G: view

Transcripts for HNF4G Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HNF4G Gene

(7) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HNF4G Gene

Hepatocyte nuclear factor 4, gamma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNF4G Gene

No ASD Table

Relevant External Links for HNF4G Gene

GeneLoc Exon Structure for
HNF4G
ECgene alternative splicing isoforms for
HNF4G

Expression for HNF4G Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNF4G Gene

mRNA expression in normal human tissues for HNF4G Gene
mRNA expression by BioGPS for HNF4G GenemRNA expression by GTEx for HNF4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HNF4G Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x19.9), Colon - Transverse (x10.9), and Liver (x5.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNF4G Gene



NURSA nuclear receptor signaling pathways regulating expression of HNF4G Gene:

HNF4G

SOURCE GeneReport for Unigene cluster for HNF4G Gene:

Hs.241529

mRNA Expression by UniProt/SwissProt for HNF4G Gene:

Q14541-HNF4G_HUMAN
Tissue specificity: Expressed in pancreas, kidney, small intestine and testis. Weakly expressed in colon. Not expressed in liver, skeletal muscle, lung, placenta, brain, heart, peripheral blood, ovary, prostate, thymus and spleen.

Evidence on tissue expression from TISSUES for HNF4G Gene

  • Liver(4.4)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with HNF4G: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNF4G Gene

Orthologs for HNF4G Gene

This gene was present in the common ancestor of animals.

Orthologs for HNF4G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HNF4G 34 35
  • 99.7 (n)
dog
(Canis familiaris)
 Mammalia HNF4G 34 35
  • 92.88 (n)
cow
(Bos Taurus)
 Mammalia HNF4G 34 35
  • 92.06 (n)
oppossum
(Monodelphis domestica)
 Mammalia HNF4G 35
  • 89 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Hnf4g 34 16 35
  • 87.02 (n)
rat
(Rattus norvegicus)
 Mammalia Hnf4g 34
  • 86.7 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia HNF4G 35
  • 74 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves HNF4G 34 35
  • 80.93 (n)
lizard
(Anolis carolinensis)
 Reptilia HNF4G 35
  • 80 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia hnf4g 34
  • 74.74 (n)
zebrafish
(Danio rerio)
 Actinopterygii hnf4g 34 35
  • 65.13 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Hnf4 36 35
  • 66 (a)
worm
(Caenorhabditis elegans)
 Secernentea nhr-64 36 34 35
  • 48.89 (n)
nhr-69 36 35
  • 38 (a)
nhr-14 36
  • 32 (a)
nhr-35 35
  • 25 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 50 (a)
 OneToMany
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.3727 34
Species where no ortholog for HNF4G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNF4G Gene

ENSEMBL:
Gene Tree for HNF4G (if available)
TreeFam:
Gene Tree for HNF4G (if available)

Paralogs for HNF4G Gene

Variants for HNF4G Gene

Sequence variations from dbSNP and Humsavar for HNF4G Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000010739 -- 75,555,352(+) TTCCT(A/G)TACTT intron-variant
rs1000030992 -- 75,413,010(+) AATGA(A/C)TTCTG intron-variant
rs1000042192 -- 75,417,239(+) CACTG(C/T)AGCCT intron-variant
rs1000050079 -- 75,564,051(+) CAAGC(A/T)TCAGT reference, synonymous-codon
rs1000056007 -- 75,485,563(+) GCTTT(A/T)ATGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNF4G Gene

Variant ID Type Subtype PubMed ID
esv3891416 CNV gain 25118596
nsv465718 CNV loss 19166990
nsv465719 CNV loss 19166990
nsv611561 CNV gain 21841781
nsv611562 CNV loss 21841781
nsv611563 CNV loss 21841781
nsv611564 CNV loss 21841781
nsv831357 CNV loss 17160897

Variation tolerance for HNF4G Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNF4G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNF4G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNF4G Gene

Disorders for HNF4G Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNF4G Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
maturity-onset diabetes of the young
  • mason-type diabetes
- elite association - COSMIC cancer census association via MalaCards
Search HNF4G in MalaCards View complete list of genes associated with diseases

Relevant External Links for HNF4G

Genetic Association Database (GAD)
HNF4G
Human Genome Epidemiology (HuGE) Navigator
HNF4G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNF4G
genes like me logo Genes that share disorders with HNF4G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNF4G Gene

Publications for HNF4G Gene

  1. Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. (PMID: 12220494) Wisely G.B. … Williams S.P. (Structure 2002) 2 3 4 64
  2. Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. (PMID: 10512380) Plengvidhya N. … Doria A. (Diabetes 1999) 3 4 22 64
  3. Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes. (PMID: 8622695) Drewes T. … Ryffel G.U. (Mol. Cell. Biol. 1996) 2 3 4 64
  4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes E.K. … Loos R.J. (Nat. Genet. 2010) 3 46 64
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4 64

Products for HNF4G Gene

Sources for HNF4G Gene

Content
Loading form....