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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNF4G Gene

protein-coding   GIFtS: 61
GCID: GC08P076370

hepatocyte nuclear factor 4, gamma
 Explore 6 diseases affiliated with
HNF4G via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HNF4G    

Aliases
for HNF4G gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Hepatocyte Nuclear Factor 4, Gamma1 2
NR2A21 2 3
Nuclear Receptor Subfamily 2 Group A Member 22 3
HNF-4-Gamma1
NR2A32
Hepatocyte Nuclear Factor 4-Gamma2

External Ids:    HGNC: 50261   Entrez Gene: 31742   Ensembl: ENSG000001647497   OMIM: 6059665   UniProtKB: Q145413   

Export aliases for HNF4G gene to outside databases

Previous GC identifers: GC08P075350 GC08P076308 GC08P076043 GC08P076502 GC08P076482 GC08P076614 GC08P071939


Summaries
for HNF4G gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: HNF4G_HUMAN, Q14541
Function: Transcription factor. Has a lower transcription activation potential than HNF4-alpha

Gene Wiki entry for HNF4G (Hepatocyte nuclear factor 4 gamma)


Genomic Views
for HNF4G gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNF4G gene promoter:
         Gfi-1   HNF-1A   GATA-6   POU2F1   POU2F1b   POU2F1a   HNF-1   HFH-1   POU2F1c   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HNF4G promoter sequence
   Search SABiosciences Chromatin IP Primers for HNF4G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNF4G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q21-q22

HNF4G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNF4G gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P076370:  view genomic region     (about GC identifiers)

Start:
 76,320,149 bp from pter      End:
 76,479,078 bp from pter
Size:
 158,930 bases      Orientation:
 plus strand

Proteins
for HNF4G gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HNF4G_HUMAN, Q14541 (See protein sequence)
Recommended Name: Hepatocyte nuclear factor 4-gamma  
Size: 408 amino acids; 45877 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=CAE11875.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for HNF4G:
1LV2 (3D)    
Secondary accessions: Q7Z2V9 Q9UH81 Q9UIS6
Alternative splicing: 2 isoforms:  Q14541-1   Q14541-2   

Explore the universe of human proteins at neXtProt for HNF4G: NX_Q14541

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14541

    • HNF4G Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004124.4  
    ENSEMBL proteins: 
     ENSP00000346339   ENSP00000379701  
    Reactome Protein details: Q14541
    Human Recombinant Protein Products: 
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    Novus Biologicals HNF4G Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--


    HNF4G for ontologies           About GeneDecksing



    HNF4G Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for HNF4G gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HNF4G for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR003068 COUP_TF
     IPR001723 Str_hrmn_rcpt
     IPR013088 Znf_NHR/GATA
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core

    Graphical View of Domain Structure for InterPro Entry Q14541

    ProtoNet protein and cluster: Q14541

    2 Blocks protein families:
    IPB000003 Retinoic acid receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: HNF4G_HUMAN, Q14541
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Function
    for HNF4G gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HNF4G_HUMAN, Q14541
    Function: Transcription factor. Has a lower transcription activation potential than HNF4-alpha

         Genatlas biochemistry entry for HNF4G:
    hepatocyte nuclear factor 4 gamma,steroid/thyroid receptor superfamily,expressed in kidney,pancreas,small
    intestine,testis,colon,not in the liver,involved in differential transcriptional regulation,not playing a major role
    in the etiology of early onst autosomal dominant,non insulin dependent type 2,diabetes

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HNF4G
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate HNF4G (see all 49):
    hsa-miR-26a-2* hsa-miR-128 hsa-miR-29a hsa-miR-30d hsa-miR-449a hsa-miR-570 hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: HNF4G 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: HNF4G
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNF4G 

    Cell Line
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    Search LifeMap BioReagents cell lines for HNF4G

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNF4G

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8622695
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--


    HNF4G for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for HNF4G:
     Synthetic lethal with Ras  Synthetic lethal with cisplati 

    Animal Models:
         Mouse knock-out Hnf4gtm1Dgen for HNF4G
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hnf4g):
     behavior/neurological  growth/size  homeostasis/metabolism  respiratory system 

    HNF4G for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HNF4G gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of beta-cell development
    		Regulation of beta-cell development1.00
    		Regulation of gene expression in beta cells0.56
    		Maturity onset diabetes of the young0.56
    2Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    3Nuclear Receptor transcription pathway
    		Nuclear Receptor transcription pathway1.00
    4HNF1A-dependent synthesis of HNF4G protein
    		HNF1A-dependent synthesis of HNF4G protein1.00
    5Selected targets of HNF1
    		Selected targets of HNF11.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for HNF4G
        Selected targets of HNF1

    1 R&D Systems Pathway for HNF4G
        TGF-beta Signaling Pathways


    5/7        Reactome Pathways for HNF4G (see all 7)
        HNF1A-dependent synthesis of HNF4G protein
    Regulation of gene expression in beta cells
    Developmental Biology
    Generic Transcription Pathway
    Nuclear Receptor transcription pathway


    1         Kegg Pathway  (Kegg details for HNF4G):
        Maturity onset diabetes of the young


    HNF4G for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HNF4G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for HNF4G (Q145413 ENSP000003797014) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LOC100996626Q9NPJ43I2D: score=3 
    PNRC2Q9NPJ43I2D: score=3 
    NR0B2Q154663, ENSP000002542274I2D: score=4 STRING: ENSP00000254227
    HLFQ165343, ENSP000002260674I2D: score=1 STRING: ENSP00000226067
    MAPK1P284823I2D: score=4 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8622695
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0031018endocrine pancreas development TAS--
    GO:0045893positive regulation of transcription, DNA-dependent IEA--


    HNF4G for ontologies           About GeneDecksing



    Drugs & Compounds
    for HNF4G gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HNF4G

    1 DrugBank Compound for HNF4G    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Palmitic Acid1-Hexyldecanoic Acid (see all 11)57-10-3target----

    Search CenterWatch for drugs/clinical trials and news about HNF4G 

    Transcripts
    for HNF4G gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HNF4G gene: 
    NM_004133.4  

    Unigene Cluster for HNF4G:

    Hepatocyte nuclear factor 4, gamma
    Hs.241529  [show with all ESTs]
    Unigene Representative Sequence: BX571750
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494318 ENST00000396419 ENST00000354370(uc003yap.1) ENST00000396423(uc003yaq.3 uc003yar.3)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HNF4G
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate HNF4G (see all 49):
    hsa-miR-26a-2* hsa-miR-128 hsa-miR-29a hsa-miR-30d hsa-miR-449a hsa-miR-570 hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: HNF4G 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HNF4G (see all 7)
    OriGene shRNA RFP: HNF4G
    OriGene siRNA: HNF4G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HNF4G
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB307704.1 AK025222.1 BC054009.1 BC105009.1 BC105011.1 BX571750.1 CR542091.1 HQ692842.1 
    Z49826.2 

    4 DOTS entries:

    DT.201667  DT.99956474  DT.91766788  DT.86839229 

    24/29 AceView cDNA sequences (see all 29):

    AA376961 BX479624 BC054009 BX483384 BX571750 AI733811 NM_004133 AI640317 
    BX483393 T06086 AK025222 BX480426 AI264658 AI792633 BU568685 Z49826 
    AI916600 AA757207 BX497911 BM980563 CR542091 BX480863 BG434065 AW473174 

    GeneLoc Exon Structure


    Expression
    for HNF4G gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNF4G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAAATTATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HNF4G expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    BoneMaxillary ProcessBone
    Gut TubeMidgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Early limb mesenchymal cells (ELM cells) (Primary Cell)Bone, Cartilage, Limb
    Late limb mesenchymal cells (LLM cells) (Primary Cell)Bone, Cartilage, Limb

    See HNF4G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNF4G

    SOURCE GeneReport for Unigene cluster: Hs.241529

    UniProtKB/Swiss-Prot: HNF4G_HUMAN, Q14541
    Tissue specificity: Expressed in pancreas, kidney, small intestine and testis. Weakly expressed in colon. Not expressed
    in liver, skeletal muscle, lung, placenta, brain, heart, peripheral blood, ovary, prostate, thymus and spleen

        SABiosciences Custom PCR Arrays for HNF4G
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    In Situ
    Assay Products:     
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    Orthologs
    for HNF4G gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HNF4G gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HNF4G1 hepatocyte nuclear factor 4, gamma 80.93(n)
    87.16(a)    		   428364  XM_425924.3  XP_425924.3 
    lizard
    (Anolis carolinensis)    		 Reptilia HNF4G6
    		 --
    		 83(a)
    		 1 ↔ 1
    		 4(34366724-34389715)
    zebrafish
    (Danio rerio)    		 Actinopterygii hnf4g1 hepatocyte nuclear factor 4, gamma 65.35(n)
    70.83(a)    		   557104  NM_001075111.1  NP_001068579.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hnf43 endoderm development transcription factor 66(a)   2 29E4   --
    worm
    (Caenorhabditis elegans)    		 Secernentea nhr-641 , 3 hormone receptor/zinc finger protein3
    Protein NHR-641    		 42(a)
    (best of 3)3
    48.89(n)1
    44.24(a)1    		   I(3104240-3109523)3
    1718841  NM_001025871.21  NP_001021042.21 


    ENSEMBL Gene Tree for HNF4G (if available)
    TreeFam Gene Tree for HNF4G (if available) 

    Paralogs
    for HNF4G gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HNF4G gene
    ESRRA2  RXRG2  PGR2  ESR22  ESRRB2  NR2F62  NR2E12  ESRRG2  
    NR3C22  RXRA2  NR2F12  NR3C12  NR2F22  AR2  ESR12  NR2C12  
    HNF4A2  NR2C22  RXRB2  
    18/65 SIMAP similar genes for HNF4G using alignment to 3 protein entries:     HNF4G_HUMAN (see all proteins) (see all similar genes):
    NR2A2    NR2A3    HNF4alpha    ESRRA    NR2C2    NR2A1
    THRA    BCOR-RARA    DKFZp761C0417    HNF4A    NR1B1    NR1F1
    NR2C1    RORA    RARA    RARB    NR1F2    RORB

    HNF4G for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HNF4G
    PGOHUM00000248409


    Genomic Variants
    for HNF4G gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/589 NCBI SNPs in HNF4G are shown (see all 589)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs29435461,2
    		C,F,--76450238(+) CTAAAT/GAAACC 1 -- us2k110Minor allele frequency- G:0.30NA WA CSA EA 371
    rs779515581,2
    		C,F,--76450243(+) GAAACC/TGCTTC 1 -- us2k12Minor allele frequency- T:0.03NA EA 240
    rs760070671,2
    		--76450292(+) TCTACA/CTCTGA 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1887966761,2
    		--76450302(+) AATATC/TATTAC 1 -- us2k10--------
    rs575251591,2
    		C,F,--76450446(+) ATGCCA/GACTCT 1 -- us2k14Minor allele frequency- G:0.05WA CSA NA 242
    rs1114075041,2
    		--76450534(+) GGATCC/TGGTAC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1816052131,2
    		--76450548(+) CACCCA/GCGGGA 1 -- us2k10--------
    rs1864210441,2
    		--76450551(+) CCGCGA/GGAACA 1 -- us2k10--------
    rs1467608351,2
    		--76450620(+) TCTTTC/TAGTGT 1 -- us2k10--------
    rs29779271,2
    		C,H--76450941(+) ATTAAG/AAGTAT 1 -- us2k14Minor allele frequency- A:0.00NS EA 418

    HapMap Linkage Disequilibrium report for HNF4G (76320149 - 76479078 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HNF4G: --

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    Disorders / Diseases
    for HNF4G gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HNF4G for disorders           About GeneDecksing

    OMIM gene information: 605966    OMIM disorders: --

    6 diseases for HNF4G:    About MalaCards
    maturity-onset diabetes of the young    hepatocellular carcinoma    thyroiditis    carcinoma
    hepatitis    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: HNF4G (1 document)

    Export disorders for HNF4G gene to outside databases

    Publications
    for HNF4G gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNF4G gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with HNF4G)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. (PubMed id 12220494)1, 2, 3 Wisely G.B.... Williams S.P. (2002)
    2. Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes. (PubMed id 8622695)1, 2, 3 Drewes T.... Ryffel G.U. (1996)
    3. Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. (PubMed id 10512380)1, 2, 9 Plengvidhya N.... Doria A. (1999)
    4. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
    5. Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers. (PubMed id 12544512)1, 9 Ozeki T....Kamataki T. (2003)
    6. Proteomic analysis of native hepatocyte nuclear facto r-4I+ (HNF4I+) isoforms, phosphorylation status, and interactive cofactors. (PubMed id 21047794)1 Daigo K....Hamakubo T. (2011)
    7. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1 Speliotes E.K....Loos R.J. (2010)
    8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Systematic association mapping identifies NELL1 as a novel IBD disease gene. (PubMed id 17684544)1 Franke A....Schreiber S. (2007)

    External Searches for HNF4G gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HNF4G gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3174 HGNC: 5026 AceView: HNF4G Ensembl:ENSG00000164749 euGenes: HUgn3174
    ECgene: HNF4G Kegg: 3174 H-InvDB: HNF4G

    Other Databases showing HNF4G gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HNF4G gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNF4G Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Hepatocyte_nuclear_factors

    Intellectual Property
    for HNF4G gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HNF4G gene:
    Search GeneIP for patents involving HNF4G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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