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Aliases for HNF4G Gene

Aliases for HNF4G Gene

  • Hepatocyte Nuclear Factor 4, Gamma 2 3
  • Nuclear Receptor Subfamily 2 Group A Member 2 3 4
  • HNF-4-Gamma 3 4
  • NR2A2 3 4
  • Hepatocyte Nuclear Factor 4-Gamma 3
  • NR2A3 3

External Ids for HNF4G Gene

Previous GeneCards Identifiers for HNF4G Gene

  • GC08P075350
  • GC08P076308
  • GC08P076043
  • GC08P076370
  • GC08P076502
  • GC08P076482
  • GC08P076614
  • GC08P071939

Summaries for HNF4G Gene

GeneCards Summary for HNF4G Gene

HNF4G (Hepatocyte Nuclear Factor 4, Gamma) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Regulation of beta-cell development. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and steroid hormone receptor activity. An important paralog of this gene is RXRG.

UniProtKB/Swiss-Prot for HNF4G Gene

  • Transcription factor. Has a lower transcription activation potential than HNF4-alpha

Gene Wiki entry for HNF4G Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNF4G Gene

Genomics for HNF4G Gene

Regulatory Elements for HNF4G Gene

Genomic Location for HNF4G Gene

75,407,914 bp from pter
75,566,843 bp from pter
158,930 bases
Plus strand

Genomic View for HNF4G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNF4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNF4G Gene

Proteins for HNF4G Gene

  • Protein details for HNF4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatocyte nuclear factor 4-gamma
    Protein Accession:
    Secondary Accessions:
    • Q7Z2V9
    • Q9UH81
    • Q9UIS6

    Protein attributes for HNF4G Gene

    408 amino acids
    Molecular mass:
    45877 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAE11875.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNF4G Gene

    Alternative splice isoforms for HNF4G Gene


neXtProt entry for HNF4G Gene

Proteomics data for HNF4G Gene at MOPED

Post-translational modifications for HNF4G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HNF4G Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HNF4G Gene

Domains for HNF4G Gene

Gene Families for HNF4G Gene

Suggested Antigen Peptide Sequences for HNF4G Gene

Graphical View of Domain Structure for InterPro Entry



  • Q14541
  • Contains 1 nuclear receptor DNA-binding domain.
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with HNF4G: view

Function for HNF4G Gene

Molecular function for HNF4G Gene

GENATLAS Biochemistry: hepatocyte nuclear factor 4 gamma,steroid/thyroid receptor superfamily,expressed in kidney,pancreas,small intestine,testis,colon,not in the liver,involved in differential transcriptional regulation,not playing a major role in the etiology of early onst autosomal dominant,non insulin dependent type 2,diabetes
UniProtKB/Swiss-Prot Function: Transcription factor. Has a lower transcription activation potential than HNF4-alpha

Gene Ontology (GO) - Molecular Function for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8622695
GO:0003707 steroid hormone receptor activity IEA --
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HNF4G: view
genes like me logo Genes that share phenotypes with HNF4G: view

Animal Models for HNF4G Gene

MGI Knock Outs for HNF4G:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HNF4G Gene

Localization for HNF4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNF4G Gene

Subcellular locations from

Jensen Localization Image for HNF4G Gene COMPARTMENTS Subcellular localization image for HNF4G gene
Compartment Confidence
nucleus 4
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HNF4G: view

Pathways for HNF4G Gene

genes like me logo Genes that share pathways with HNF4G: view

Pathways by source for HNF4G Gene

Gene Ontology (GO) - Biological Process for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8622695
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0030522 intracellular receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with HNF4G: view

Compounds for HNF4G Gene

(1) Drugbank Compounds for HNF4G Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Palmitic Acid
  • 1-Hexyldecanoic Acid
57-10-3 target
genes like me logo Genes that share compounds with HNF4G: view

Transcripts for HNF4G Gene

Unigene Clusters for HNF4G Gene

Hepatocyte nuclear factor 4, gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNF4G Gene

No ASD Table

Relevant External Links for HNF4G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HNF4G Gene

mRNA expression in normal human tissues for HNF4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HNF4G Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (19.9), Colon - Transverse (10.9), and Liver (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNF4G Gene

SOURCE GeneReport for Unigene cluster for HNF4G Gene Hs.241529

mRNA Expression by UniProt/SwissProt for HNF4G Gene

Tissue specificity: Expressed in pancreas, kidney, small intestine and testis. Weakly expressed in colon. Not expressed in liver, skeletal muscle, lung, placenta, brain, heart, peripheral blood, ovary, prostate, thymus and spleen
genes like me logo Genes that share expressions with HNF4G: view

Orthologs for HNF4G Gene

This gene was present in the common ancestor of animals.

Orthologs for HNF4G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HNF4G 35
  • 99.7 (n)
  • 99.78 (a)
HNF4G 36
  • 100 (a)
(Bos Taurus)
Mammalia HNF4G 35
  • 92.06 (n)
  • 96.23 (a)
HNF4G 36
  • 96 (a)
(Canis familiaris)
Mammalia HNF4G 35
  • 92.88 (n)
  • 96.85 (a)
HNF4G 36
  • 93 (a)
(Mus musculus)
Mammalia Hnf4g 35
  • 87.02 (n)
  • 95.91 (a)
Hnf4g 16
Hnf4g 36
  • 96 (a)
(Monodelphis domestica)
Mammalia HNF4G 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia HNF4G 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Hnf4g 35
  • 86.7 (n)
  • 94.95 (a)
(Gallus gallus)
Aves HNF4G 35
  • 80.93 (n)
  • 87.16 (a)
HNF4G 36
  • 85 (a)
(Anolis carolinensis)
Reptilia HNF4G 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hnf4g 35
  • 74.74 (n)
  • 83.94 (a)
(Danio rerio)
Actinopterygii hnf4g 35
  • 65.13 (n)
  • 69.59 (a)
hnf4g 36
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hnf4 36
  • 34 (a)
Hnf4 37
  • 66 (a)
(Caenorhabditis elegans)
Secernentea nhr-35 36
  • 25 (a)
nhr-64 35
  • 48.89 (n)
  • 44.24 (a)
nhr-64 36
  • 40 (a)
nhr-69 36
  • 38 (a)
nhr-64 37
  • 42 (a)
nhr-69 37
  • 38 (a)
nhr-14 37
  • 32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3727 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for HNF4G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNF4G Gene

Gene Tree for HNF4G (if available)
Gene Tree for HNF4G (if available)

Paralogs for HNF4G Gene

Paralogs for HNF4G Gene Pseudogenes for HNF4G Gene

genes like me logo Genes that share paralogs with HNF4G: view

Variants for HNF4G Gene

Sequence variations from dbSNP and Humsavar for HNF4G Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1399563 -- 75,550,148(-) AAAAT(A/G)TCATT intron-variant
rs1464093 -- 75,561,823(+) ATGCA(A/G)ATGAC intron-variant
rs1515020 -- 75,565,355(+) TTTAA(C/T)CAGAC utr-variant-3-prime
rs1800922 -- 75,547,491(+) GAACC(A/G)AATTT intron-variant
rs1800923 -- 75,551,520(+) TCAAA(A/C)CCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNF4G Gene

Variant ID Type Subtype PubMed ID
dgv7807n71 CNV Loss 21882294
nsv831357 CNV Loss 17160897
nsv891028 CNV Gain 21882294
dgv7808n71 CNV Loss 21882294
nsv465718 CNV Loss 19166990
nsv465719 CNV Loss 19166990

Relevant External Links for HNF4G Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNF4G Gene

Disorders for HNF4G Gene

Relevant External Links for HNF4G

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HNF4G: view

No data available for UniProtKB/Swiss-Prot for HNF4G Gene

Publications for HNF4G Gene

  1. Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. (PMID: 10512380) Plengvidhya N. … Doria A. (Diabetes 1999) 3 4 23
  2. Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes. (PMID: 8622695) Drewes T. … Ryffel G.U. (Mol. Cell. Biol. 1996) 2 3 4
  3. Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. (PMID: 12220494) Wisely G.B. … Williams S.P. (Structure 2002) 2 3 4
  4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes E.K. … Loos R.J. (Nat. Genet. 2010) 3 48
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4

Products for HNF4G Gene

Sources for HNF4G Gene

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