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Aliases for HNF4A Gene

Aliases for HNF4A Gene

  • Hepatocyte Nuclear Factor 4 Alpha 2 3 5
  • Nuclear Receptor Subfamily 2 Group A Member 1 3 4
  • Transcription Factor HNF-4 3 4
  • Transcription Factor 14 3 4
  • TCF-14 3 4
  • TCF14 3 4
  • NR2A1 3 4
  • HNF4 3 4
  • Hepatocyte Nuclear Factor 4-Alpha 3
  • Hepatic Nuclear Factor 4 Alpha 3
  • HNF4alpha10/11/12 3
  • HNF-4-Alpha 4
  • HNF4alpha 3
  • HNF4a7 3
  • HNF4a8 3
  • HNF4a9 3
  • NR2A21 3
  • FRTS4 3
  • MODY1 3
  • MODY 3
  • TCF 3

External Ids for HNF4A Gene

Previous HGNC Symbols for HNF4A Gene

  • TCF14
  • MODY
  • MODY1

Previous GeneCards Identifiers for HNF4A Gene

  • GC20P042758
  • GC20P043668
  • GC20P043715
  • GC20P042463
  • GC20P042984
  • GC20P039720

Summaries for HNF4A Gene

Entrez Gene Summary for HNF4A Gene

  • The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

GeneCards Summary for HNF4A Gene

HNF4A (Hepatocyte Nuclear Factor 4 Alpha) is a Protein Coding gene. Diseases associated with HNF4A include Mody, Type I and Fanconi Renotubular Syndrome 4, With Maturity-Onset Diabetes Of The Young. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and Regulation of beta-cell development. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HNF4G.

UniProtKB/Swiss-Prot for HNF4A Gene

  • Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.

Gene Wiki entry for HNF4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNF4A Gene

Genomics for HNF4A Gene

Regulatory Elements for HNF4A Gene

Enhancers for HNF4A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F044421 1.3 Ensembl ENCODE 20 +73.8 73825 15.2 PKNOX1 ATF1 MLX ARID4B DMAP1 YBX1 YY1 SLC30A9 ZNF143 PAF1 HNF4A LOC105372629 FITM2 LINC01430 LINC01620 PKIG MIR3646
GH20F044392 1.6 FANTOM5 Ensembl ENCODE 14.3 +39.1 39063 4.9 MLX ARID4B DMAP1 YY1 SLC30A9 PAF1 SP5 NFYC ZHX2 MXD4 HNF4A OSER1 LINC01430 LINC01620 OSER1-AS1 HNF4A-AS1 GC20P044393
GH20F044324 0.8 Ensembl ENCODE 12.2 -31.1 -31146 0.5 STAT1 SMARCA4 POLR2A ZIC2 LOC105372629 HNF4A OSER1 FITM2 R3HDML
GH20F044397 1.1 ENCODE 8.7 +53.6 53555 22.8 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B YBX1 DMAP1 YY1 SLC30A9 IFT52 FITM2 LINC01430 LINC01620 HNF4A OSER1-AS1 MIR3646
GH20F044467 0.9 FANTOM5 ENCODE 4.7 +111.7 111673 0.3 NFYC YBX1 NR3C1 RAD21 YY1 SSRP1 ATF3 HNF4G NR2F6 ZBTB33 PKIG HNF4A TTPAL RPL37AP1 GC20P044473
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HNF4A on UCSC Golden Path with GeneCards custom track

Promoters for HNF4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001837648 500 1200 ELF3 TBP MLX ZFP64 ARID4B DMAP1 ZNF48 ZSCAN9 RAD21 DNMT3B

Genomic Location for HNF4A Gene

Chromosome:
20
Start:
44,355,700 bp from pter
End:
44,434,596 bp from pter
Size:
78,897 bases
Orientation:
Plus strand

Genomic View for HNF4A Gene

Genes around HNF4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNF4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNF4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNF4A Gene

Proteins for HNF4A Gene

  • Protein details for HNF4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41235-HNF4A_HUMAN
    Recommended name:
    Hepatocyte nuclear factor 4-alpha
    Protein Accession:
    P41235
    Secondary Accessions:
    • A5JW41
    • B2RPP8
    • O00659
    • O00723
    • Q14540
    • Q5QPB8
    • Q6B4V5
    • Q6B4V6
    • Q6B4V7
    • Q92653
    • Q92654
    • Q92655
    • Q99864
    • Q9NQH0

    Protein attributes for HNF4A Gene

    Size:
    474 amino acids
    Molecular mass:
    52785 Da
    Quaternary structure:
    • Homodimerization is required for HNF4-alpha to bind to its recognition site. Interacts with PER2.
    Miscellaneous:
    • Binds fatty acids.
    SequenceCaution:
    • Sequence=AAB48082.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA54248.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA61133.1; Type=Frameshift; Positions=2, 7; Evidence={ECO:0000305}; Sequence=CAA61134.1; Type=Frameshift; Positions=2, 7; Evidence={ECO:0000305}; Sequence=CAA61135.1; Type=Frameshift; Positions=2, 7; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNF4A Gene

    Alternative splice isoforms for HNF4A Gene

neXtProt entry for HNF4A Gene

Post-translational modifications for HNF4A Gene

  • Acetylation at Lys-458 lowers transcriptional activation by about two-fold.
  • Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA.
  • Ubiquitination at Lys 234 and Lys 307
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNF4A Gene

Domains & Families for HNF4A Gene

Gene Families for HNF4A Gene

Graphical View of Domain Structure for InterPro Entry

P41235

UniProtKB/Swiss-Prot:

HNF4A_HUMAN :
  • Contains 1 nuclear receptor DNA-binding domain.
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with HNF4A: view

Function for HNF4A Gene

Molecular function for HNF4A Gene

GENATLAS Biochemistry:
transcription factor 4,hepatocyte nuclear factor 4 alpha,steroid/thyroid hormone receptor superfamily,coexpressed with TCF1 and binding TCF1 promoter (see also RGHE),including the alternatively spliced isoforms HNF4A1,HNF4A2,HNF4A4,expressed in pancreatic beta cells,regulating expression of genes required for glucose transport and metabolism,and of sex hormones-binding globulin,interacting with TCF1 for regulation of gene activity and chromatin structure of serpin cluster (PI)
UniProtKB/Swiss-Prot Function:
Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.

Gene Ontology (GO) - Molecular Function for HNF4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISS --
GO:0001102 RNA polymerase II activating transcription factor binding ISS --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003677 DNA binding IEA,IDA 7615825
genes like me logo Genes that share ontologies with HNF4A: view
genes like me logo Genes that share phenotypes with HNF4A: view

Human Phenotype Ontology for HNF4A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HNF4A Gene

MGI Knock Outs for HNF4A:

Animal Model Products

Targeted motifs for HNF4A Gene
HOMER Transcription Factor Regulatory Elements motif HNF4A
  • Consensus sequence: CAGAGGNCAAAGTCCA Submotif: DR1 Cell Type: HepG2 GEO ID: GSE25021

Clone Products

  • Addgene plasmids for HNF4A

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for HNF4A Gene

Localization for HNF4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNF4A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNF4A gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for HNF4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 7615825
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 14563941
genes like me logo Genes that share ontologies with HNF4A: view

Pathways & Interactions for HNF4A Gene

genes like me logo Genes that share pathways with HNF4A: view

SIGNOR curated interactions for HNF4A Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HNF4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IMP 18163890
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with HNF4A: view

Drugs & Compounds for HNF4A Gene

(52) Drugs for HNF4A Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbamazepine Approved, Investigational Pharma 131
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1918
Efavirenz Approved, Investigational Pharma Reverse transcriptase inhibitor 405
Lamotrigine Approved, Investigational Pharma 5-HT inhibitor 183
Warfarin Approved Pharma 454

(25) Additional Compounds for HNF4A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for HNF4A Gene

Compound Action Cas Number
BI 6015 HNF4α antagonist 93987-29-2
genes like me logo Genes that share compounds with HNF4A: view

Transcripts for HNF4A Gene

Unigene Clusters for HNF4A Gene

Hepatocyte nuclear factor 4, alpha:
Representative Sequences:

Clone Products

  • Addgene plasmids for HNF4A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNF4A Gene

No ASD Table

Relevant External Links for HNF4A Gene

GeneLoc Exon Structure for
HNF4A
ECgene alternative splicing isoforms for
HNF4A

Expression for HNF4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HNF4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HNF4A Gene

This gene is overexpressed in Liver (x23.8), Colon - Transverse (x11.2), Kidney - Cortex (x7.0), and Small Intestine - Terminal Ileum (x6.0).

Protein differential expression in normal tissues from HIPED for HNF4A Gene

This gene is overexpressed in Liver, secretome (53.1) and Liver (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNF4A Gene



Protein tissue co-expression partners for HNF4A Gene

NURSA nuclear receptor signaling pathways regulating expression of HNF4A Gene:

HNF4A

SOURCE GeneReport for Unigene cluster for HNF4A Gene:

Hs.116462
genes like me logo Genes that share expression patterns with HNF4A: view

No data available for mRNA Expression by UniProt/SwissProt for HNF4A Gene

Orthologs for HNF4A Gene

This gene was present in the common ancestor of animals.

Orthologs for HNF4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNF4A 34 35
  • 92.92 (n)
cow
(Bos Taurus)
Mammalia HNF4A 34 35
  • 92.53 (n)
dog
(Canis familiaris)
Mammalia HNF4A 34 35
  • 92.33 (n)
oppossum
(Monodelphis domestica)
Mammalia HNF4A 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnf4a 34
  • 90.15 (n)
mouse
(Mus musculus)
Mammalia Hnf4a 34 16 35
  • 89.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HNF4A 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNF4ALPHA 35
  • 88 (a)
OneToOne
HNF4A 34
  • 82.16 (n)
lizard
(Anolis carolinensis)
Reptilia HNF4A 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnf4a 34
  • 74.01 (n)
African clawed frog
(Xenopus laevis)
Amphibia hnf4-prov 34
zebrafish
(Danio rerio)
Actinopterygii hnf4a 34 35
  • 72.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002155 34
  • 65.36 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hnf4 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhr-64 35
  • 42 (a)
ManyToMany
nhr-69 35
  • 38 (a)
ManyToMany
nhr-35 35
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToMany
Species where no ortholog for HNF4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNF4A Gene

ENSEMBL:
Gene Tree for HNF4A (if available)
TreeFam:
Gene Tree for HNF4A (if available)

Paralogs for HNF4A Gene

Paralogs for HNF4A Gene

(19) SIMAP similar genes for HNF4A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HNF4A: view

Variants for HNF4A Gene

Sequence variations from dbSNP and Humsavar for HNF4A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs137853336 Maturity-onset diabetes of the young 1 (MODY1) [MIM:125850], Pathogenic 44,413,714(+) GGGAC(C/T)GGATC reference, missense
rs137853337 Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853], Pathogenic 44,428,409(+) CCAAC(A/G)TCATC reference, missense
rs137853338 Maturity-onset diabetes of the young 1 (MODY1) [MIM:125850], Pathogenic 44,424,243(+) GGAGA(G/T)GCTGC reference, missense
rs587777732 Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young (FRTS4) [MIM:616026], Pathogenic 44,406,195(+) TCTTC(C/T)GGAGG upstream-variant-2KB, reference, missense
VAR_010601 Maturity-onset diabetes of the young 1 (MODY1) [MIM:125850]

Structural Variations from Database of Genomic Variants (DGV) for HNF4A Gene

Variant ID Type Subtype PubMed ID
nsv819556 CNV insertion 19587683
nsv586065 CNV gain 21841781
nsv1061719 CNV gain 25217958
nsv1057847 CNV loss 25217958
esv3557112 CNV deletion 23714750
esv2663976 CNV deletion 23128226
esv2504273 CNV insertion 19546169

Variation tolerance for HNF4A Gene

Residual Variation Intolerance Score: 6.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HNF4A Gene

Human Gene Mutation Database (HGMD)
HNF4A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HNF4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNF4A Gene

Disorders for HNF4A Gene

MalaCards: The human disease database

(20) MalaCards diseases for HNF4A Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mody, type i
  • maturity-onset diabetes of the young, type 1
fanconi renotubular syndrome 4, with maturity-onset diabetes of the young
  • fanconi renotubular syndrome 4 with maturity-onset diabetes of the young
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
hyperinsulinism
  • hyperinsulinemia
hyperinsulinism due to hnf4a deficiency
  • hyperinsulinemic hypoglycemia due to hnf4a deficiency
- elite association - COSMIC cancer census association via MalaCards
Search HNF4A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HNF4A_HUMAN
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:9449683}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
  • Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young (FRTS4) [MIM:616026]: A disease characterized by Fanconi syndrome associated with a beta cell phenotype of neonatal hyperinsulinism with macrosomia and young onset diabetes. Fanconi syndrome is a proximal tubulopathy resulting in generalised aminoaciduria, low molecular weight proteinuria, glycosuria, hyperphosphaturia and hypouricemia. Some FRTS4 patients have nephrocalcinosis, renal impairment, hypercalciuria with relative hypocalcemia, and hypermagnesemia. {ECO:0000269 PubMed:22802087, ECO:0000269 PubMed:24285859}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Maturity-onset diabetes of the young 1 (MODY1) [MIM:125850]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. {ECO:0000269 PubMed:17407387, ECO:0000269 PubMed:9243109, ECO:0000269 PubMed:9313765}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HNF4A

Genetic Association Database (GAD)
HNF4A
Human Genome Epidemiology (HuGE) Navigator
HNF4A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HNF4A
genes like me logo Genes that share disorders with HNF4A: view

No data available for Genatlas for HNF4A Gene

Publications for HNF4A Gene

  1. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity- onset diabetes of the young (MODY1). (PMID: 8945471) Yamagata K. … Bell G.I. (Nature 1996) 3 4 22 46 64
  2. Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations. (PMID: 20164212) Flanagan S.E. … Ellard S. (Eur. J. Endocrinol. 2010) 3 22 46 64
  3. Mutations of maturity-onset diabetes of the young (MODY) genes in Thais with early-onset type 2 diabetes mellitus. (PMID: 18811724) Plengvidhya N. … Yenchitsomanus P.T. (Clin. Endocrinol. (Oxf) 2009) 3 22 46 64
  4. Mutations in the coding regions of the hepatocyte nuclear factor 4 alpha in Iranian families with maturity onset diabetes of the young. (PMID: 20003313) Taghavi S.M. … Valizadeh N. (Cardiovasc Diabetol 2009) 3 22 46 64
  5. PXR, CAR and HNF4alpha genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patients. (PMID: 17876342) Hor S.Y. … Tan T. (Pharmacogenomics J. 2008) 3 22 46 64

Products for HNF4A Gene

Sources for HNF4A Gene

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