Aliases for HNF1B Gene
External Ids for HNF1B Gene
Previous Symbols for HNF1B Gene
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
GeneCards Summary for HNF1B Gene
HNF1B (HNF1 Homeobox B) is a Protein Coding gene. Diseases associated with HNF1B include renal cysts and diabetes syndrome and clear cell adenocarcinoma. Among its related pathways are L1CAM interactions and Regulation of beta-cell development. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.
UniProtKB/Swiss-Prot for HNF1B Gene
Transcription factor, probably binds to the inverted palindrome 5-GTTAATNATTAAC-3