HN1L Gene
protein-coding GIFtS: 47
GCID: GC16P001728
|
|
hematological and neurological expressed 1-like(Previous name: chromosome 16 open reading frame 34 )
(Previous symbol: C16orf34)
| |
Aliases
for HN1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hematological And Neurological Expressed 1-Like1 2 | | KIAA14261 | | C16orf341 2 3 | | Chromosome 16 Open Reading Frame 341 | | L111 2 | | CRAMP_1 Like2 | | HN1-Like Protein2 3 | | Hematological And Neurological Expressed 1-Like Protein2 | | FLJ130921 | | HN1 Like2 |
Export aliases for HN1L gene to outside databasesPrevious GC identifers: GC16P001745 GC16P001669 |
Summaries
for HN1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for HN1L
|
Genomic Views
for HN1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HN1L gene promoter:
Nkx3-1 ER-alpha Nkx3-1 v4 FOXD1 Nkx3-1 v1 FOXL1 Nkx3-1 v2 Nkx3-1 v3 ZIC2/Zic2 ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for HN1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HN1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3HN1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P001728: view genomic region
(about GC identifiers)
Start:
|
1,728,257 bp from pter |
End:
|
1,752,281 bp from pter |
Size:
|
24,025 bases |
Orientation:
|
plus strand |
|
Proteins
for HN1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HN1L_HUMAN, Q9H910 (See
protein sequence)Recommended Name: Hematological and neurological expressed 1-like protein Size: 190 amino acids; 20063 Da
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: B1AJY2 Q6EIC7Alternative splicing: 2 isoforms: Q9H910-1 Q9H910-2 Explore the universe of human proteins at neXtProt for HN1L: NX_Q9H910
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H910
HN1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653171.1
ENSEMBL proteins: ENSP00000248098 ENSP00000457694 ENSP00000454459 ENSP00000372158 ENSP00000454567 ENSP00000456487 ENSP00000457536 ENSP00000454529 ENSP00000372157 ENSP00000457424 ENSP00000457344
Human Recombinant Protein Products for HN1L:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
HN1L for ontologies About GeneDecksing
HN1L Antibody Products:
Assay Products for HN1L: |
Protein
Domains /
Families
for HN1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9H910 UniProtKB/Swiss-Prot: HN1L_HUMAN, Q9H910Similarity: Belongs to the HN1 family |
Function
for HN1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: HN1L_HUMAN, Q9H910Induction: Up-regulated in squamous cell carcinoma (SCC) adenocarcinoma (AC), adenosquamous cell carcinoma (ASCC),bronchioalveolar carcinoma (BAC), breast and uterus tumorsAnimal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HN1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HN1L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HN1L (NM_144570) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HN1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HN1L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HN1L |
|
Pathways & Interactions
for HN1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HN1L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/10 Interacting proteins for HN1L (Q9H9103 ENSP000002480984) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for HN1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HN1L
Search CenterWatch for drugs/clinical trials and news about HN1L
|
Transcripts
for HN1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HN1L gene: NM_144570.2 Unigene Cluster for HN1L: Hematological and neurological expressed 1-like Hs.513261 [show with all ESTs]Unigene Representative Sequence: NM_14457014 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000569256 ENST00000248098(uc002cmg.3 uc010uvi.2 uc010brt.3 uc010bru.3 uc010uvj.2 uc010uvk.2)
ENST00000567717 ENST00000562684 ENST00000561516 ENST00000382711 ENST00000566742
ENST00000566925 ENST00000569765 ENST00000566691 ENST00000382710 ENST00000565851
ENST00000568376 ENST00000562569
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HN1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HN1L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HN1L (NM_144570) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HN1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HN1L |
Additional cDNA sequence: AK023154.1 AK296888.1 AK296998.1 AK303927.1 AK304025.1 AK309909.1 AK309930.1 AK316514.1 AY323978.1 AY323979.1 AY598330.1 BC014438.1 BC060853.1 17 DOTS entries: DT.447081 DT.101984350 DT.97798267 DT.100822295 DT.95242040 DT.100822302 DT.120683083 DT.120683100 DT.120683101 DT.95242045 DT.120683026 DT.120683088 DT.40121190 DT.95151191 DT.100037828 DT.120683049 DT.95087963 24/513 AceView cDNA sequences (see all 513): BQ926222 BQ053288 BI495984 CB216987 AI783915 BM827994 AI284087 AU131102 CB120638 BQ575138 NM_144570 AI962918 BQ670301 AA173785 AB037847 BU688026 BM475735 BM913495 BF058896 BM451163 AW130130 AA324457 AI564597 BQ689857
GeneLoc Exon Structure
|
Expression
for HN1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HN1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAGCCCTGC
About this image
See HN1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HN1L
SOURCE GeneReport for Unigene cluster: Hs.513261
UniProtKB/Swiss-Prot: HN1L_HUMAN, Q9H910Tissue specificity: Expressed in liver, kidney, prostate, testis and uterus
SABiosciences Custom PCR Arrays for HN1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HN1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HN1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HN1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HN1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HN1L |
Orthologs
for HN1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HN1L gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for HN1L (if available)
TreeFam Gene Tree for HN1L (if available) |
Paralogs
for HN1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HN1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HN1L (1728257 - 1752281 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HN1L
1 CNV: 5329 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HN1L |
|
Disorders
/ Diseases
for HN1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HN1L for disorders About GeneDecksing
6  diseases for HN1L: About MalaCardscramps squamous cell carcinoma lung cancer adenocarcinoma
carcinoma prostatitis
Human Genome Epidemiology (HuGE) Navigator: HN1L (1 document)
Export disorders for HN1L gene to outside databases
|
Publications
for HN1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HN1L gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with HN1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, expression and subcellular localization of HN1 and HN1L genes, as well as characterization of their orthologs, defining an evolutionarily conserved gene family. (PubMed id 15094197)1, 2, 3, 9 Zhou G.... Zhao S. (2004)
- Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for HN1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HN1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HN1L gene
(According to HUGE)
About This Section
| |
Specialized Databases showing HN1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HN1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HN1L gene:
Search GeneIP for patents involving HN1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HN1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HN1L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HN1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HN1L | | | OriGene Protein Over-expression Lysate for HN1L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HN1L | | OriGene 3'-UTR Clone for HN1L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HN1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HN1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HN1L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HN1L | | OriGene Custom Protein Services for HN1L | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HN1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HN1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HN1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HN1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HN1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HN1L |
| |
 |  |  |  | |
| | | | Search Tocris compounds for HN1L |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | HN1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HN1L |
|  |  |  |  | | | | ThermoFisher Antibody for HN1L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HN1L |
| |  | |
|
|
|
