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Aliases for HN1L Gene

Aliases for HN1L Gene

  • Hematological And Neurological Expressed 1-Like 2 3 5
  • HN1-Like Protein 3 4
  • C16orf34 3 4
  • Chromosome 16 Open Reading Frame 34 2
  • CRAMP_1 Like 3
  • HN1 Like 3
  • L11 3

External Ids for HN1L Gene

Previous HGNC Symbols for HN1L Gene

  • C16orf34

Previous GeneCards Identifiers for HN1L Gene

  • GC16P001745
  • GC16P001669
  • GC16P001728

Summaries for HN1L Gene

GeneCards Summary for HN1L Gene

HN1L (Hematological And Neurological Expressed 1-Like) is a Protein Coding gene.

Gene Wiki entry for HN1L Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HN1L Gene

Genomics for HN1L Gene

Regulatory Elements for HN1L Gene

Enhancers for HN1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HN1L on UCSC Golden Path with GeneCards custom track

Promoters for HN1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HN1L on UCSC Golden Path with GeneCards custom track

Genomic Location for HN1L Gene

1,678,256 bp from pter
1,702,280 bp from pter
24,025 bases
Plus strand

Genomic View for HN1L Gene

Genes around HN1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HN1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HN1L Gene

Proteins for HN1L Gene

  • Protein details for HN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hematological and neurological expressed 1-like protein
    Protein Accession:
    Secondary Accessions:
    • B1AJY2
    • B4DLH4
    • Q6EIC7

    Protein attributes for HN1L Gene

    190 amino acids
    Molecular mass:
    20063 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HN1L Gene


neXtProt entry for HN1L Gene

Proteomics data for HN1L Gene at MOPED

Post-translational modifications for HN1L Gene

  • Glycosylation at Thr 159
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HN1L Gene

Domains & Families for HN1L Gene

Protein Domains for HN1L Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HN1 family.
  • Belongs to the HN1 family.
genes like me logo Genes that share domains with HN1L: view

No data available for Gene Families for HN1L Gene

Function for HN1L Gene

Molecular function for HN1L Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated in squamous cell carcinoma (SCC) adenocarcinoma (AC), adenosquamous cell carcinoma (ASCC), bronchioalveolar carcinoma (BAC), breast and uterus tumors.

Phenotypes for HN1L Gene

GenomeRNAi human phenotypes for HN1L:
genes like me logo Genes that share phenotypes with HN1L: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HN1L Gene

Localization for HN1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for HN1L Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for HN1L Gene COMPARTMENTS Subcellular localization image for HN1L gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for HN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with HN1L: view

Pathways & Interactions for HN1L Gene

SuperPathways for HN1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for HN1L Gene


No data available for Pathways by source and SIGNOR curated interactions for HN1L Gene

Drugs & Compounds for HN1L Gene

No Compound Related Data Available

Transcripts for HN1L Gene

Unigene Clusters for HN1L Gene

Hematological and neurological expressed 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HN1L Gene

No ASD Table

Relevant External Links for HN1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HN1L Gene

mRNA expression in normal human tissues for HN1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HN1L Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.0).

Protein differential expression in normal tissues from HIPED for HN1L Gene

This gene is overexpressed in Heart (13.1), Peripheral blood mononuclear cells (8.5), and Fetal ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HN1L Gene

SOURCE GeneReport for Unigene cluster for HN1L Gene Hs.513261

mRNA Expression by UniProt/SwissProt for HN1L Gene

Tissue specificity: Expressed in liver, kidney, prostate, testis and uterus.
genes like me logo Genes that share expression patterns with HN1L: view

Primer Products

No data available for Protein tissue co-expression partners for HN1L Gene

Orthologs for HN1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for HN1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HN1L 35
  • 78.57 (n)
  • 79.12 (a)
HN1L 36
  • 65 (a)
(Canis familiaris)
Mammalia HN1L 35
  • 82.62 (n)
  • 80.85 (a)
HN1L 36
  • 57 (a)
(Mus musculus)
Mammalia Hn1l 35
  • 80.88 (n)
  • 79.47 (a)
Hn1l 16
Hn1l 36
  • 79 (a)
(Pan troglodytes)
Mammalia HN1L 35
  • 99.65 (n)
  • 99.47 (a)
HN1L 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Hn1l 35
  • 80.7 (n)
  • 78.95 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 65 (a)
-- 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia HN1L 36
  • 65 (a)
(Gallus gallus)
Aves HN1L 35
  • 67.55 (n)
  • 64.36 (a)
HN1L 36
  • 63 (a)
(Anolis carolinensis)
Reptilia HN1L 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hn1l 35
  • 57.58 (n)
  • 57.34 (a)
(Danio rerio)
Actinopterygii hn1l 35
  • 54.72 (n)
  • 49.73 (a)
wufb37f03 35
hn1l 36
  • 39 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.297 35
Species with no ortholog for HN1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HN1L Gene

Gene Tree for HN1L (if available)
Gene Tree for HN1L (if available)

Paralogs for HN1L Gene

(1) SIMAP similar genes for HN1L Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with HN1L: view

No data available for Paralogs for HN1L Gene

Variants for HN1L Gene

Sequence variations from dbSNP and Humsavar for HN1L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10771 -- 1,699,357(-) ACAGG(C/T)TGTTT utr-variant-3-prime
rs12002 -- 1,701,716(-) CTCTG(C/T)TTCTC utr-variant-3-prime
rs8062111 -- 1,688,695(+) atagc(A/G)aggcc intron-variant
rs12935294 -- 1,690,702(+) CTTCA(C/G)ATAAA intron-variant
rs9635641 -- 1,686,943(+) ATGTA(C/G)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HN1L Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904954 CNV Loss 21882294
nsv905017 CNV Loss 21882294
nsv428317 CNV Gain 18775914
nsv833118 CNV Loss 17160897
nsv518641 CNV Loss 19592680

Variation tolerance for HN1L Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HN1L Gene

Disorders for HN1L Gene

Relevant External Links for HN1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HN1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HN1L Gene

Publications for HN1L Gene

  1. Cloning, expression and subcellular localization of HN1 and HN1L genes, as well as characterization of their orthologs, defining an evolutionarily conserved gene family. (PMID: 15094197) Zhou G. … Zhao S. (Gene 2004) 2 3 4 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. (PMID: 24550385) Abu-Odeh M. … Aqeilan R.I. (J. Biol. Chem. 2014) 3
  5. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PMID: 22412018) Roux K.J. … Burke B. (J. Cell Biol. 2012) 3

Products for HN1L Gene

Sources for HN1L Gene