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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HN1L Gene

protein-coding   GIFtS: 49
GCID: GC16P001728

Hematological And Neurological Expressed 1-Like

(Previous name: chromosome 16 open reading frame 34)
(Previous symbol: C16orf34)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hematological And Neurological Expressed 1-Like1 2     L112
C16orf341 2 3     CRAMP_1 Like2
HN1-Like Protein2 3     Hematological And Neurological Expressed 1-Like Protein2
Chromosome 16 Open Reading Frame 341     HN1 Like2

External Ids:    HGNC: 141371   Entrez Gene: 908612   Ensembl: ENSG000002060537   UniProtKB: Q9H9103   

Export aliases for HN1L gene to outside databases

Previous GC identifers: GC16P001745 GC16P001669


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HN1L Gene: 
HN1L (hematological and neurological expressed 1-like) is a protein-coding gene. Diseases associated with HN1L include lung cancer, and squamous cell carcinoma.

Gene Wiki entry for HN1L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HN1L gene promoter:
         Nkx3-1   ER-alpha   Nkx3-1 v4   FOXD1   Nkx3-1 v1   FOXL1   Nkx3-1 v2   Nkx3-1 v3   ZIC2/Zic2   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHN1L promoter sequence
   Search SABiosciences Chromatin IP Primers for HN1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HN1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

HN1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HN1L gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P001728:  view genomic region     (about GC identifiers)

Start:
1,728,257 bp from pter      End:
1,752,281 bp from pter
Size:
24,025 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HN1L_HUMAN, Q9H910 (See protein sequence)
Recommended Name: Hematological and neurological expressed 1-like protein  
Size: 190 amino acids; 20063 Da
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: B1AJY2 Q6EIC7
Alternative splicing: 2 isoforms:  Q9H910-1   Q9H910-2   

Explore the universe of human proteins at neXtProt for HN1L: NX_Q9H910

Explore proteomics data for HN1L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H910

  • HN1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HN1L Protein Expression
    REFSEQ proteins: NP_653171.1  
    ENSEMBL proteins: 
     ENSP00000248098   ENSP00000457694   ENSP00000454459   ENSP00000372158   ENSP00000454567  
     ENSP00000456487   ENSP00000457536   ENSP00000454529   ENSP00000372157   ENSP00000457424  
     ENSP00000457344  

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    Novus Biologicals HN1L Proteins
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HN1L
    Cloud-Clone Corp. Proteins for HN1L 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    HN1L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9H910

    UniProtKB/Swiss-Prot: HN1L_HUMAN, Q9H910
    Similarity: Belongs to the HN1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HN1L_HUMAN, Q9H910
    Induction: Up-regulated in squamous cell carcinoma (SCC) adenocarcinoma (AC), adenosquamous cell carcinoma (ASCC),
    bronchioalveolar carcinoma (BAC), breast and uterus tumors

    Animal Models:

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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidHN1L 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HN1L


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HN1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for HN1L (Q9H9103 ENSP000002480984) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNTFRP269923, ENSP000002423384I2D: score=1 STRING: ENSP00000242338
    CSNK1DP487303, ENSP000003244644I2D: score=1 STRING: ENSP00000324464
    SEPT2Q150193, ENSP000003531574I2D: score=1 STRING: ENSP00000353157
    SLC25A20O437723, ENSP000003263054I2D: score=3 STRING: ENSP00000326305
    XRCC6P129563I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HN1L

    Search CenterWatch for drugs/clinical trials and news about HN1L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HN1L gene: 
    NM_144570.2  

    Unigene Cluster for HN1L:

    Hematological and neurological expressed 1-like
    Hs.513261  [show with all ESTs]
    Unigene Representative Sequence: NM_144570
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000569256 ENST00000248098(uc002cmg.3 uc010uvi.2 uc010brt.3 uc010bru.3 uc010uvj.2 uc010uvk.2)
    ENST00000567717 ENST00000562684 ENST00000561516 ENST00000382711 ENST00000566742
    ENST00000566925 ENST00000569765 ENST00000566691 ENST00000382710 ENST00000565851
    ENST00000568376 ENST00000562569
    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate HN1L (see all 14):
    hsa-miR-4272 hsa-miR-4312 hsa-miR-409-3p hsa-miR-522 hsa-miR-1224-3p hsa-miR-1271 hsa-miR-888 hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidHN1L 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HN1L
    Sirion Biotech Customized lentivirus for stable overexpression of HN1L 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HN1L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HN1L

    Additional mRNA sequence: 

    AK023154.1 AK296888.1 AK296998.1 AK303927.1 AK304025.1 AK309909.1 AK309930.1 AK316514.1 
    AY323978.1 AY323979.1 AY598330.1 BC014438.1 BC060853.1 

    17 DOTS entries:

    DT.447081  DT.101984350  DT.97798267  DT.100822295  DT.95242040  DT.100822302  DT.120683083  DT.120683100 
    DT.120683101  DT.95242045  DT.120683026  DT.120683088  DT.40121190  DT.95151191  DT.100037828  DT.120683049 
    DT.95087963 

    24/513 AceView cDNA sequences (see all 513):

    AW439814 AK023154 BC014438 BQ689857 BC060853 BQ670301 BI094322 AY323979 
    BU688026 BM828091 AI962918 NM_144570 AU139715 F12295 AA324457 BF058896 
    BM451163 AW130130 AY323978 BM913495 AI078330 CD723303 AK056087 BG055320 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HN1L expression in normal human tissues (normalized intensities)      HN1L embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGCCCTGC
    HN1L Expression
    About this image


    HN1L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer

    See HN1L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HN1L

    SOURCE GeneReport for Unigene cluster: Hs.513261

    UniProtKB/Swiss-Prot: HN1L_HUMAN, Q9H910
    Tissue specificity: Expressed in liver, kidney, prostate, testis and uterus

        SABiosciences Custom PCR Arrays for HN1L
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HN1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HN1L gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hn1l1 , 5 hematological and neurological expressed 1-like1, 5 80.88(n)1
    79.47(a)1
      17 (12.53 cM)5
    520091  NM_198937.21  NP_945175.11 
     249424705 
    chicken
    (Gallus gallus)
    Aves HN1L1 hematological and neurological expressed 1-like 71.51(n)
    66.67(a)
      416763  NM_001030651.1  NP_001025822.1 
    lizard
    (Anolis carolinensis)
    Reptilia HN1L6
    Uncharacterized protein
    51(a)
    1 ↔ 1
    GL343649.1(166882-171829)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ031005.12   -- 72.91(n)    BJ031005.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb37f032 wufb37f03 72.66(n)   321880  BC045436.1 


    ENSEMBL Gene Tree for HN1L (if available)
    TreeFam Gene Tree for HN1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HN1L gene
    1 SIMAP similar gene for HN1L using alignment to 10 protein entries:     HN1L_HUMAN (see all proteins):
    HN1

    HN1L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/498 SNPs in HN1L are shown (see all 498)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1448751691,2
    --1728546(+) GAGGGA/GCCGCT 1 -- int10--------
    rs1880838211,2
    --1728552(+) CCGCTC/TGCTGA 1 -- int10--------
    rs71968481,2
    C,F--1728689(+) GGTGCG/TTTCCG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1486079611,2
    --1728712(+) TGGGGA/GCGGGG 1 -- int10--------
    rs776679731,2
    C,F--1728714(+) GGGGCG/AGGGTG 1 -- int11Minor allele frequency- A:0.09EA 120
    rs799943101,2
    C,F--1728755(+) GGATGC/AGTGTC 1 -- int11Minor allele frequency- A:0.09EA 120
    rs1421298021,2
    --1728824(+) TGGCCA/GTGCCC 1 -- int10--------
    rs767388161,2
    C,F--1728879(+) TGTGGC/ACTGTG 1 -- int11Minor allele frequency- A:0.06WA 118
    rs1928783981,2
    --1728913(+) CTAGTA/TCATGT 1 -- int10--------
    rs1853179371,2
    --1729108(+) CACTCG/TTTGGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for HN1L (1728257 - 1752281 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for HN1L:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv518641CNV Loss19592680
    nsv904954CNV Loss21882294
    nsv905017CNV Loss21882294
    nsv833118CNV Loss17160897
    nsv428317CNV Gain18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for HN1L:    About MalaCards
    lung cancer    squamous cell carcinoma    adenocarcinoma    gastric cancer
    prostatitis


    HN1L for disorders           About GeneDecksing

    Genetic Association Database (GAD): HN1L
    Human Genome Epidemiology (HuGE) Navigator: HN1L (1 document)

    Export disorders for HN1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HN1L gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with HN1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and subcellular localization of HN1 and HN1L genes, as well as characterization of their orthologs, defining an evolutionarily conserved gene family. (PubMed id 15094197)1, 2, 3, 9 Zhou G.... Zhao S. (2004)
    2. Genetic variants associated with cardiac structure an d function: a meta-analysis and replication of genome-wide association data. (PubMed id 19584346)1, 4 Vasan R.S....Blankenberg S. (2009)
    3. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90861 HGNC: 14137 AceView: CRAMP1L Ensembl:ENSG00000206053 euGenes: HUgn90861
    ECgene: HN1L H-InvDB: HN1L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HN1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HN1L gene:
    Search GeneIP for patents involving HN1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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