HN1 Gene
protein-coding GIFtS: 51
GCID: GC17M073129
|
|
hematological and neurological expressed 1
| |
Aliases
for HN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hematological And Neurological Expressed 11 2 | | ARM21 2 3 | | HN1A1 2 | | Androgen-Regulated Protein 22 3 | | Hematological And Neurological Expressed 1 Protein2 | | OPMRX605 |
Export aliases for HN1 gene to outside databasesPrevious GC identifers: GC17M076191 GC17M073595 GC17M073728 GC17M073731 GC17M070642 GC17M068540 |
Summaries
for HN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for HN1
|
Genomic Views
for HN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HN1 gene promoter:
AREB6 p53 CP2 MyoD POU6F1 (c2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for HN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC chromosome: 17HN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M073129: view genomic region
(about GC identifiers)
Start:
|
73,131,343 bp from pter |
End:
|
73,164,376 bp from pter |
Size:
|
33,034 bases |
Orientation:
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minus strand |
|
Proteins
for HN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HN1_HUMAN, Q9UK76 (See
protein sequence)Recommended Name: Hematological and neurological expressed 1 protein Size: 154 amino acids; 16015 Da
Subcellular location: Nucleus
Secondary accessions: B2R6K3 Q53FG7 Q7Z2D2 Q7Z2F0Alternative splicing: 3 isoforms: Q9UK76-1 Q9UK76-2 Q9UK76-3 (Either acetylated on Met-1, or acetylated on Ala-2 after Met-1 removal)Explore the universe of human proteins at neXtProt for HN1: NX_Q9UK76
Post-translational modifications:
Isoform 3 initiator methionine is either acetylated or removed. In the latter case, the new N-terminal amino acid isthen N-acetylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UK76
HN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001002032.1 NP_001002033.1 NP_057269.1
ENSEMBL proteins: ENSP00000464266 ENSP00000387059 ENSP00000462834 ENSP00000303110 ENSP00000348316 ENSP00000386690 ENSP00000462784 ENSP00000462478 ENSP00000376353 ENSP00000462493 ENSP00000462805 ENSP00000384619 ENSP00000440912
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
HN1 for ontologies About GeneDecksing
HN1 Antibody Products:
Assay Products for HN1: |
Protein
Domains /
Families
for HN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9UK76 UniProtKB/Swiss-Prot: HN1_HUMAN, Q9UK76Similarity: Belongs to the HN1 family |
Function
for HN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HN1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HN1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): HN1 (NM_001025201) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HN1 |
1 GenomeRNAi human phenotype for HN1:
|
Pathways & Interactions
for HN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Apoptosis Modulation and Signaling | |
1  BioSystems Pathway for HN1
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HN1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for HN1 (Q9UK762, 3 ENSP000003483164) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for HN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HN1
Search CenterWatch for drugs/clinical trials and news about HN1
|
Transcripts
for HN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HN1 gene (3 alternative transcripts): NM_001002032.1 NM_001002033.1 NM_016185.2 Unigene Cluster for HN1: Hematological and neurological expressed 1 Hs.532803 [show with all ESTs]Unigene Representative Sequence: BC03934316 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000476258 ENST00000409753(uc002jna.1 uc002jnb.1) ENST00000482348
ENST00000304834 ENST00000356033 ENST00000409135 ENST00000470924 ENST00000481094
ENST00000481647 ENST00000392573 ENST00000580380 ENST00000581874 ENST00000584079
ENST00000465454 ENST00000405458(uc002jmz.1) ENST00000392566
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HN1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HN1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): HN1 (NM_001025201) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HN1 |
Additional cDNA sequence: AF060925.1 AF086910.2 AF177862.1 AF266846.1 AK223321.1 AK308253.1 AK312613.1 AY322169.1 AY322170.1 BC001420.2 BC039343.1 21 DOTS entries: DT.100672830 DT.100644255 DT.449235 DT.92451392 DT.92451393 DT.92451388 DT.120997800 DT.95142723 DT.100862836 DT.95258169 DT.100646944 DT.101957724 DT.120997839 DT.100030667 DT.120997835 DT.91732581 DT.92451394 DT.95258141 DT.100658307 DT.100672837 DT.99988829 24/1667 AceView cDNA sequences (see all 1667): BE790599 BQ772224 CA867448 AI026988 AI805615 AY322169 BM312331 AW001143 AW151365 T52778 BP343192 CB216845 AA782099 CB125604 T29957 CB107305 BM263148 AI626013 BQ267728 BE254823 BM699388 AW163059 CB267948 AA460509
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for HN1 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | - | | - | | | | - | | | | - | | - | | - | | | | |
| SP3: | | | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for HN1
|
Expression
for HN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTGTGAACT
About this image
See HN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HN1
SOURCE GeneReport for Unigene cluster: Hs.532803
UniProtKB/Swiss-Prot: HN1_HUMAN, Q9UK76Tissue specificity: Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain andplacenta
SABiosciences Custom PCR Arrays for HN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HN1 |
Orthologs
for HN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HN1 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for HN1 (if available)
TreeFam Gene Tree for HN1 (if available) |
Paralogs
for HN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HN1 gene
1 SIMAP similar gene for HN1 using alignment to 6 protein entries: HN1_HUMAN (see all proteins):HN1L
HN1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for HN1
PGOHUM00000240427
|
Genomic Variants
for HN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HN1 (73131343 - 73164376 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HN1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HN1 |
|
Disorders
/ Diseases
for HN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HN1 for disorders About GeneDecksing
OMIM gene information: 300127
OMIM disorders: 300486
7  diseases for HN1: About MalaCardsmental retardation, x-linked cerebellar hypoplasia testicular leukemia neutropenia
leukemia prostatitis carcinoma
Export disorders for HN1 gene to outside databases
|
Publications
for HN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HN1 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with HN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, expression and subcellular localization of HN1 and HN1L genes, as well as characterization of their orthologs, defining an evolutionarily conserved gene family. (PubMed id 15094197)1, 2, 3 Zhou G.... Zhao S. (2004)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins. (PubMed id 16602700)1, 2 Zougman A. and Wisniewski J.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Androgen regulated HN1 leads proteosomal degradation o f androgen receptor (AR) and negatively influences AR mediated transactivation i n prostate cells. (PubMed id 22155408)1 Varisli L....Korkmaz K.S. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Ubiquitously expressed hematological and neurological expressed 1 downregulates Akt-mediated GSK3I^ signaling, and its knockdown resu lts in deregulated G2/M transition in prostate cells. (PubMed id 21323578)1 Varisli L....Korkmaz K.S. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for HN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HN1 gene:
Search GeneIP for patents involving HN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for HN1 | | OriGene shRNA RFP for HN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HN1 | | | OriGene Protein Over-expression Lysate for HN1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HN1 | | OriGene 3'-UTR Clone for HN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HN1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HN1 | | OriGene Custom Protein Services for HN1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HN1 |
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| | | | Search Tocris compounds for HN1 |
| |  |  |  |  | | | | |
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 | | | HN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HN1 |
|  |  |  | | | | ThermoFisher Antibodies for HN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HN1 |
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