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HN1 Gene

protein-coding   GIFtS: 56
GCID: GC17M073129

Hematological And Neurological Expressed 1

  See HN1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hematological And Neurological Expressed 11 2
Androgen-Regulated Protein 21 2 3
ARM22 3
HN1A2
Hematological And Neurological Expressed 1 Protein2
OPMRX605

External Ids:    HGNC: 145691   Entrez Gene: 511552   Ensembl: ENSG000001891597   OMIM: 3001275   UniProtKB: Q9UK763   

Export aliases for HN1 gene to outside databases

Previous GC identifers: GC17M076191 GC17M073595 GC17M073728 GC17M073731 GC17M070642 GC17M068540


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HN1 Gene:
HN1 (hematological and neurological expressed 1) is a protein-coding gene. Diseases associated with HN1 include testicular leukemia.

Gene Wiki entry for HN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HN1 gene promoter:
         AREB6   p53   CP2   MyoD   POU6F1 (c2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHN1 promoter sequence
   Search Chromatin IP Primers for HN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

HN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HN1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M073129:  view genomic region     (about GC identifiers)

Start:
73,131,343 bp from pter      End:
73,164,376 bp from pter
Size:
33,034 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HN1_HUMAN, Q9UK76 (See protein sequence)
Recommended Name: Hematological and neurological expressed 1 protein  
Size: 154 amino acids; 16015 Da
Secondary accessions: B2R6K3 Q53FG7 Q7Z2D2 Q7Z2F0
Alternative splicing: 3 isoforms:  Q9UK76-1   Q9UK76-2   Q9UK76-3   

Explore the universe of human proteins at neXtProt for HN1: NX_Q9UK76

Explore proteomics data for HN1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys46, Lys64, Lys69
  • Modification sites at PhosphoSitePlus

  • See HN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001002032.1  NP_001002033.1  NP_001275538.1  NP_001275539.1  NP_001275540.1  NP_057269.1  

    ENSEMBL proteins: 
     ENSP00000464266   ENSP00000387059   ENSP00000462834   ENSP00000303110   ENSP00000348316  
     ENSP00000462784   ENSP00000462478   ENSP00000462493   ENSP00000462805   ENSP00000384619  
     ENSP00000440912  

    HN1 Human Recombinant Protein Products:

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    Novus Biologicals HN1 Proteins
    Novus Biologicals HN1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HN1
    Cloud-Clone Corp. Proteins for HN1

     
    Search eBioscience for Proteins for HN1 

    HN1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for HN1

    HN1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
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    Search eBioscience for ELISAs for HN1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9UK76

    UniProtKB/Swiss-Prot: HN1_HUMAN, Q9UK76
    Similarity: Belongs to the HN1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for HN1:
     Large cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HN1:
    hsa-mir-3187-3p (MIRT052807), hsa-mir-106b-5p (MIRT020482), hsa-mir-17-5p (MIRT050989), hsa-mir-375 (MIRT020055)

    Block miRNA regulation of human, mouse, rat HN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HN1 (see all 34):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-29a hsa-miR-570 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidHN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HN1
    Predesigned siRNA for gene silencing in human, mouse, rat HN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HN1

    Clone
    Products:
         
    OriGene clones in human, mouse for HN1 (see all 17)
    OriGene ORF clones in mouse, rat for HN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): HN1 (NM_001025201)
    Sino Biological Human cDNA Clone for HN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HN1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HN1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HN1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HN1_HUMAN, Q9UK76: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with HN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HN1 About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis (WikiPathways)
    Apoptosis Modulation and Signaling0.38


    1 BioSystems Pathway for HN1
        Apoptosis Modulation and Signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HN1
    Interactions:

        Search GeneGlobe Interaction Network for HN1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for HN1 (Q9UK762, 3 ENSP000003483164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGAP44Q17R892, 3, ENSP000003689944MINT-64756 I2D: score=5 STRING: ENSP00000368994
    SFPQP232462, 3MINT-63600 I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HN1 gene (6 alternative transcripts): 
    NM_001002032.2  NM_001002033.2  NM_001288609.1  NM_001288610.1  NM_001288611.1  NM_016185.3  

    Unigene Cluster for HN1:

    Hematological and neurological expressed 1
    Hs.532803  [show with all ESTs]
    Unigene Representative Sequence: BC039343
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476258 ENST00000409753(uc002jna.1 uc002jnb.1) ENST00000482348
    ENST00000304834 ENST00000356033 ENST00000470924 ENST00000481094 ENST00000481647
    ENST00000580380 ENST00000581874 ENST00000584079 ENST00000465454 ENST00000405458(uc002jmz.1)
    ENST00000392566
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HN1 (see all 34):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-29a hsa-miR-570 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidHN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HN1
    Predesigned siRNA for gene silencing in human, mouse, rat HN1
    Clone
    Products:
         
    OriGene clones in human, mouse for HN1 (see all 17)
    OriGene ORF clones in mouse, rat for HN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): HN1 (NM_001025201)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HN1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HN1
    OriGene qSTAR qPCR primer pairs in human, mouse for HN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HN1
      QuantiTect SYBR Green Assays in human, mouse, rat HN1
      QuantiFast Probe-based Assays in human, mouse, rat HN1

    Additional mRNA sequence: 

    AF060925.1 AF086910.2 AF177862.1 AF266846.1 AK223321.1 AK308253.1 AK312613.1 AY322169.1 
    AY322170.1 BC001420.2 BC039343.1 

    21 DOTS entries:

    DT.100672830  DT.100644255  DT.449235  DT.92451392  DT.92451393  DT.92451388  DT.120997800  DT.95142723 
    DT.100862836  DT.95258169  DT.100646944  DT.101957724  DT.120997839  DT.100030667  DT.120997835  DT.91732581 
    DT.92451394  DT.95258141  DT.100658307  DT.100672837  DT.99988829 

    Selected AceView cDNA sequences (see all 1667):

    BQ950381 BQ053257 BU726099 BQ670025 BF727003 CA308158 BI755958 CR616877 
    BX441959 AI184095 AI146570 BE883360 CR610842 AA150048 CR592277 BC022340 
    BM457142 AI608809 CB125242 BU687909 AA295443 AW272211 CR620568 BU180588 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HN1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
    SP1:              -     -     -     -     -                 -                                 
    SP2:              -     -     -     -     -     -           -           -     -     -         
    SP3:              -     -     -     -     -     -           -                                 
    SP4:              -     -     -     -     -     -                                             
    SP5:                    -     -     -     -     -           -                                 


    ECgene alternative splicing isoforms for HN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGTGAACT
    HN1 Expression
    About this image


    HN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    HN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532803

    UniProtKB/Swiss-Prot: HN1_HUMAN, Q9UK76
    Tissue specificity: Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain
    and placenta

        Custom PCR Arrays for HN1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HN1
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    QuantiFast Probe-based Assays in human, mouse, rat HN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HN1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hn11 , 5 hematological and neurological expressed sequence 11, 5 88.1(n)1
    90.26(a)1
      11 (80.84 cM)5
    153741  NM_008258.11  NP_032284.11 
     1154973535 
    chicken
    (Gallus gallus)
    Aves HN11 hematological and neurological expressed 1 73.42(n)
    71.9(a)
      422119  NM_001006425.1  NP_001006425.1 
    lizard
    (Anolis carolinensis)
    Reptilia HN16
    hematological and neurological expressed 1
    44(a)
    1 ↔ 1
    2(114759978-114772937)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hn11 hematological and neurological expressed 1 53.43(n)
    49.65(a)
      100271760  NM_001145748.1  NP_001139220.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hn1a1 hematological and neurological expressed 1a 51.54(n)
    46.05(a)
      100037360  NM_001089513.1  NP_001082982.1 


    ENSEMBL Gene Tree for HN1 (if available)
    TreeFam Gene Tree for HN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HN1 gene
    1 SIMAP similar gene for HN1 using alignment to 5 protein entries:     HN1_HUMAN (see all proteins):
    HN1L

    Find genes that share paralogs with HN1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HN1
    PGOHUM00000240427


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HN1 (see all 437)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403436701,2
    C--73130859(+) GGTGCA/G/TATCAT 3 -- ds50010--------
    rs1911808061,2
    --73130869(+) TGGCTC/TACTGC 3 -- ds50010--------
    rs1503498061,2
    --73130965(+) AGAGAC/TGAGGT 3 -- ds50010--------
    rs1379755801,2
    --73131044(+) GAGTCA/TAACCT 3 -- ds50010--------
    rs1426734721,2
    --73131265(+) CAGGAC/TTTATA 3 -- ds50010--------
    rs1830854901,2
    --73131632(+) GTTACA/TATCTG 3 -- ut310--------
    rs772841331,2
    C--73132053(+) TTCTTA/CAAAAG 3 -- ut310--------
    rs773217751,2
    C--73132070(+) AAAAAG/AGACAG 3 -- ut311Minor allele frequency- A:0.50NA 2
    rs765383541,2
    --73132071(+) AAAAAG/AACAGC 3 -- ut311Minor allele frequency- A:0.50NA 2
    rs765018881,2
    C--73132140(+) AGTTGC/TGCAGT 4 H R ut31 mis10--------

    HapMap Linkage Disequilibrium report for HN1 (73131343 - 73164376 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908756CNV Loss21882294
    nsv908758CNV Loss21882294
    nsv470602CNV Loss18288195
    nsv908757CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HN1
    DNA2.0 Custom Variant and Variant Library Synthesis for HN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300127   
    OMIM disorders: 300486  
    1 disease for HN1:    
    About MalaCards
    testicular leukemia

    1 disease from the University of Copenhagen DISEASES database for HN1:
    Testicular leukemia

    Find genes that share disorders with HN1           About GenesLikeMe


    Export disorders for HN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for HN1 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with HN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and subcellular localization of HN1 and HN1L genes, as well as characterization of their orthologs, defining an evolutionarily conserved gene family. (PubMed id 15094197)1, 2, 3 Zhou G.... Zhao S. (Gene 2004)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins. (PubMed id 16602700)1, 2 Zougman A. and Wisniewski J.R. (J. Proteome Res. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Androgen regulated HN1 leads proteosomal degradation of androgen receptor (AR) and negatively influences AR mediated transactivation in prostate cells. (PubMed id 22155408)1 Varisli L....Korkmaz K.S. (Mol. Cell. Endocrinol. 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51155 HGNC: 14569 AceView: SUMO2andHN1 Ensembl:ENSG00000189159 euGenes: HUgn51155
    ECgene: HN1 H-InvDB: HN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HN1 gene:
    Search GeneIP for patents involving HN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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