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Aliases for HN1 Gene

Aliases for HN1 Gene

  • Hematological And Neurological Expressed 1 2 3 5
  • Androgen-Regulated Protein 2 2 3 4
  • ARM2 3 4
  • HN1A 3

External Ids for HN1 Gene

Previous GeneCards Identifiers for HN1 Gene

  • GC17M073129
  • GC17M076191
  • GC17M073595
  • GC17M073728
  • GC17M073731
  • GC17M070642
  • GC17M068540

Summaries for HN1 Gene

GeneCards Summary for HN1 Gene

HN1 (Hematological And Neurological Expressed 1) is a Protein Coding gene. Diseases associated with HN1 include testicular leukemia. Among its related pathways are Apoptosis Modulation and Signaling.

Gene Wiki entry for HN1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HN1 Gene

Genomics for HN1 Gene

Regulatory Elements for HN1 Gene

Genomic Location for HN1 Gene

Chromosome:
17
Start:
75,135,243 bp from pter
End:
75,168,281 bp from pter
Size:
33,039 bases
Orientation:
Minus strand

Genomic View for HN1 Gene

Genes around HN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HN1 Gene

Proteins for HN1 Gene

  • Protein details for HN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK76-HN1_HUMAN
    Recommended name:
    Hematological and neurological expressed 1 protein
    Protein Accession:
    Q9UK76
    Secondary Accessions:
    • B2R6K3
    • Q53FG7
    • Q7Z2D2
    • Q7Z2F0

    Protein attributes for HN1 Gene

    Size:
    154 amino acids
    Molecular mass:
    16015 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HN1 Gene

Proteomics data for HN1 Gene at MOPED

Post-translational modifications for HN1 Gene

  • Ubiquitination at Lys 8, Lys 46, and Lys 64
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HN1 Gene

Domains & Families for HN1 Gene

Protein Domains for HN1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for HN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK76

UniProtKB/Swiss-Prot:

HN1_HUMAN :
  • Belongs to the HN1 family.
Family:
  • Belongs to the HN1 family.
genes like me logo Genes that share domains with HN1: view

No data available for Gene Families for HN1 Gene

Function for HN1 Gene

Phenotypes for HN1 Gene

genes like me logo Genes that share phenotypes with HN1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HN1 Gene

Localization for HN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HN1 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HN1 Gene COMPARTMENTS Subcellular localization image for HN1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with HN1: view

Pathways & Interactions for HN1 Gene

genes like me logo Genes that share pathways with HN1: view

Pathways by source for HN1 Gene

1 BioSystems pathway for HN1 Gene

Gene Ontology (GO) - Biological Process for HN1 Gene

None

No data available for SIGNOR curated interactions for HN1 Gene

Drugs & Compounds for HN1 Gene

No Compound Related Data Available

Transcripts for HN1 Gene

Unigene Clusters for HN1 Gene

Hematological and neurological expressed 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - -
SP7:
SP8: - - - -
SP9: -

Relevant External Links for HN1 Gene

GeneLoc Exon Structure for
HN1
ECgene alternative splicing isoforms for
HN1

Expression for HN1 Gene

mRNA expression in normal human tissues for HN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HN1 Gene

This gene is overexpressed in Whole Blood (x7.3).

Protein differential expression in normal tissues from HIPED for HN1 Gene

This gene is overexpressed in Frontal cortex (16.0), Amniocyte (9.1), and Nasal epithelium (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HN1 Gene



SOURCE GeneReport for Unigene cluster for HN1 Gene Hs.532803

mRNA Expression by UniProt/SwissProt for HN1 Gene

Q9UK76-HN1_HUMAN
Tissue specificity: Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.
genes like me logo Genes that share expression patterns with HN1: view

Protein tissue co-expression partners for HN1 Gene

In Situ Assay Products

Orthologs for HN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HN1 35
  • 89.61 (n)
  • 93.51 (a)
HN1 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HN1 35
  • 89.39 (n)
  • 91.56 (a)
HN1 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hn1 35
  • 88.1 (n)
  • 90.26 (a)
Hn1 16
Hn1 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HN1 35
  • 99.78 (n)
  • 100 (a)
HN1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hn1 35
  • 88.37 (n)
  • 90.6 (a)
oppossum
(Monodelphis domestica)
Mammalia HN1 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves HN1 35
  • 73.42 (n)
  • 71.9 (a)
HN1 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HN1 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hn1 35
  • 53.43 (n)
  • 49.65 (a)
zebrafish
(Danio rerio)
Actinopterygii hn1a 35
  • 51.54 (n)
  • 46.05 (a)
hn1a 36
  • 31 (a)
OneToMany
hn1b 36
  • 31 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7331 35
Species with no ortholog for HN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HN1 Gene

ENSEMBL:
Gene Tree for HN1 (if available)
TreeFam:
Gene Tree for HN1 (if available)

Paralogs for HN1 Gene

(1) SIMAP similar genes for HN1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for HN1 Gene

genes like me logo Genes that share paralogs with HN1: view

No data available for Paralogs for HN1 Gene

Variants for HN1 Gene

Sequence variations from dbSNP and Humsavar for HN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000299 -- 75,152,458(+) AAAAA(A/G)GGAAG intron-variant
rs1382508 -- 75,147,479(-) AGTTC(A/T)CCCAC intron-variant
rs3178287 -- 75,135,993(-) GAAGC(A/C)CTTTA nc-transcript-variant, utr-variant-3-prime
rs3744234 -- 75,146,874(-) AATTT(A/G)TCATG intron-variant
rs4788869 -- 75,146,011(+) gaggt(C/T)gaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HN1 Gene

Variant ID Type Subtype PubMed ID
nsv908756 CNV Loss 21882294
nsv470602 CNV Loss 18288195
nsv908757 CNV Loss 21882294
nsv908758 CNV Loss 21882294

Variation tolerance for HN1 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HN1 Gene

HapMap Linkage Disequilibrium report
HN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HN1 Gene

Disorders for HN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HN1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
testicular leukemia
- elite association - COSMIC cancer census association via MalaCards
Search HN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HN1
genes like me logo Genes that share disorders with HN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HN1 Gene

Publications for HN1 Gene

  1. Cloning, expression and subcellular localization of HN1 and HN1L genes, as well as characterization of their orthologs, defining an evolutionarily conserved gene family. (PMID: 15094197) Zhou G. … Zhao S. (Gene 2004) 2 3 4 67
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1. (PMID: 25450365) Zhang Z.G. … Zhang B.X. (Biochem. Biophys. Res. Commun. 2014) 3
  5. Androgen regulated HN1 leads proteosomal degradation of androgen receptor (AR) and negatively influences AR mediated transactivation in prostate cells. (PMID: 22155408) Varisli L. … Korkmaz K.S. (Mol. Cell. Endocrinol. 2012) 3

Products for HN1 Gene

Sources for HN1 Gene

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