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Aliases for HN1 Gene

Aliases for HN1 Gene

  • Hematological And Neurological Expressed 1 2 3 5
  • Androgen-Regulated Protein 2 2 3 4
  • ARM2 3 4
  • Hematological And Neurological Expressed 1 Protein 3
  • HN1A 3

External Ids for HN1 Gene

Previous GeneCards Identifiers for HN1 Gene

  • GC17M073129
  • GC17M076191
  • GC17M073595
  • GC17M073728
  • GC17M073731
  • GC17M070642
  • GC17M068540

Summaries for HN1 Gene

GeneCards Summary for HN1 Gene

HN1 (Hematological And Neurological Expressed 1) is a Protein Coding gene. Diseases associated with HN1 include Testicular Leukemia. Among its related pathways are Apoptosis Modulation and Signaling.

Gene Wiki entry for HN1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HN1 Gene

Genomics for HN1 Gene

Regulatory Elements for HN1 Gene

Enhancers for HN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F075075 1.6 FANTOM5 Ensembl ENCODE 11.8 +89.5 89481 6.0 MLX ARID4B DMAP1 ZNF48 ZNF143 FOS SP5 MXD4 TBX21 PPARG ATP5H HN1 KCTD2 MRPS7 TMEM94 MIR6785 TRIM80P SLC16A5 HID1 MRPL58
GH17F075113 1 ENCODE 12.4 +53.8 53811 1.6 HDGF ATF1 ARID4B SIN3A ZNF48 GATA2 ZNF143 DEK MXD4 MIER2 NUP85 HN1 ATP5H KCTD2 SLC16A5 ARMC7 GC17P075119 PIR52086
GH17F075109 1 ENCODE 12.4 +58.2 58230 2.0 PKNOX1 WRNIP1 ARID4B SIN3A ZNF48 GTF3C2 KLF7 KLF13 SP3 SP5 NUP85 UNK NT5C ENSG00000266980 H3F3B HN1 ATP5H KCTD2 TSEN54 ARMC7
GH17F075072 1 ENCODE 11.8 +96.1 96081 0.2 PKNOX1 ATF1 ARNT ARID4B FOS MXD4 ZHX2 NCOA1 KAT8 MBD2 ATP5H KCTD2 HN1 MIR6785 TMEM94 TRIM80P PIR52580
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HN1 Gene

75,135,243 bp from pter
75,168,281 bp from pter
33,039 bases
Minus strand

Genomic View for HN1 Gene

Genes around HN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HN1 Gene

Proteins for HN1 Gene

  • Protein details for HN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hematological and neurological expressed 1 protein
    Protein Accession:
    Secondary Accessions:
    • B2R6K3
    • Q53FG7
    • Q7Z2D2
    • Q7Z2F0

    Protein attributes for HN1 Gene

    154 amino acids
    Molecular mass:
    16015 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HN1 Gene


neXtProt entry for HN1 Gene

Post-translational modifications for HN1 Gene

  • Ubiquitination at Lys 8, Lys 46, and Lys 64
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HN1 Gene

Domains & Families for HN1 Gene

Protein Domains for HN1 Gene


Suggested Antigen Peptide Sequences for HN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HN1 family.
  • Belongs to the HN1 family.
genes like me logo Genes that share domains with HN1: view

No data available for Gene Families for HN1 Gene

Function for HN1 Gene

Phenotypes for HN1 Gene

genes like me logo Genes that share phenotypes with HN1: view

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HN1 Gene

Localization for HN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HN1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HN1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for HN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with HN1: view

Pathways & Interactions for HN1 Gene

genes like me logo Genes that share pathways with HN1: view

Pathways by source for HN1 Gene

1 BioSystems pathway for HN1 Gene

Gene Ontology (GO) - Biological Process for HN1 Gene


No data available for SIGNOR curated interactions for HN1 Gene

Transcripts for HN1 Gene

Unigene Clusters for HN1 Gene

Hematological and neurological expressed 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - -
SP8: - - - -
SP9: -

Relevant External Links for HN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HN1 Gene

This gene is overexpressed in Whole Blood (x7.3).

Protein differential expression in normal tissues from HIPED for HN1 Gene

This gene is overexpressed in Frontal cortex (16.0), Amniocyte (9.1), and Nasal epithelium (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HN1 Gene

Protein tissue co-expression partners for HN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HN1 Gene:


SOURCE GeneReport for Unigene cluster for HN1 Gene:


mRNA Expression by UniProt/SwissProt for HN1 Gene:

Tissue specificity: Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.
genes like me logo Genes that share expression patterns with HN1: view

Orthologs for HN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HN1 34 35
  • 99.78 (n)
(Bos Taurus)
Mammalia HN1 34 35
  • 89.61 (n)
(Canis familiaris)
Mammalia HN1 34 35
  • 89.39 (n)
(Rattus norvegicus)
Mammalia Hn1 34
  • 88.37 (n)
(Mus musculus)
Mammalia Hn1 34 16 35
  • 88.1 (n)
(Monodelphis domestica)
Mammalia HN1 35
  • 55 (a)
(Gallus gallus)
Aves HN1 34 35
  • 73.42 (n)
(Anolis carolinensis)
Reptilia HN1 35
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hn1 34
  • 53.43 (n)
(Danio rerio)
Actinopterygii hn1a 34 35
  • 51.54 (n)
hn1b 35
  • 31 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7331 34
Species where no ortholog for HN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HN1 Gene

Gene Tree for HN1 (if available)
Gene Tree for HN1 (if available)

Paralogs for HN1 Gene

(1) SIMAP similar genes for HN1 Gene using alignment to 5 proteins: Pseudogenes for HN1 Gene

genes like me logo Genes that share paralogs with HN1: view

No data available for Paralogs for HN1 Gene

Variants for HN1 Gene

Sequence variations from dbSNP and Humsavar for HN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000299 -- 75,152,458(+) AAAAA(A/G)GGAAG intron-variant
rs10593769 -- 75,151,024(+) AACTC(-/TTTTA)TTTTT intron-variant
rs10657292 -- 75,155,552(+) CCCCC(-/C)CGGGC upstream-variant-2KB
rs10706887 -- 75,155,683(+) CTTTC(-/T)TTTTT upstream-variant-2KB
rs11077776 -- 75,141,092(+) tctca(A/G)aaaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HN1 Gene

Variant ID Type Subtype PubMed ID
nsv470602 CNV loss 18288195

Variation tolerance for HN1 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HN1 Gene

Disorders for HN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HN1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
testicular leukemia
- elite association - COSMIC cancer census association via MalaCards
Search HN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HN1 Gene

Publications for HN1 Gene

  1. Cloning, expression and subcellular localization of HN1 and HN1L genes, as well as characterization of their orthologs, defining an evolutionarily conserved gene family. (PMID: 15094197) Zhou G. … Zhao S. (Gene 2004) 2 3 4 64
  2. Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins. (PMID: 16602700) Zougman A. … Wisniewski J.R. (J. Proteome Res. 2006) 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. HN1 negatively influences the I^-catenin/E-cadherin interaction, and contributes to migration in prostate cells. (PMID: 25169422) Varisli L. … Korkmaz K.S. (J. Cell. Biochem. 2015) 3 64

Products for HN1 Gene

Sources for HN1 Gene

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