HMX3 Gene
protein-coding GIFtS: 39
GCID: GC10P124884
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H6 family homeobox 3(Previous name: homeo box (H6 family) 3 )
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Aliases
for HMX3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| H6 Family Homeobox 31 2 | | NKX-5.12 3 | | Homeo Box (H6 Family) 31 2 | | NKX5.12 5 | | NKX5-11 3 | | Nkx5-12 | | Homeobox Protein H6 Family Member 32 3 | | Homeobox (H6 Family) 32 | | Homeobox Protein Nkx-5.12 3 | | Homeobox Protein HMX32 |
Export aliases for HMX3 gene to outside databasesPrevious GC identifers: GC00U990140 GC10U900563 GC10P118513 |
Summaries
for HMX3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HMX3_HUMAN, A6NHT5Function: Transcription factor involved in specification of neuronal cell types and which is required for inner ear andhypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the innerear. Also required for hypothalamic/pituitary axis of the CNS (By similarity)
|
Genomic Views
for HMX3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HMX3 gene promoter:
p53 NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HMX3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMX3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.13 Ensembl cytogenetic band: 10q26.13 HGNC cytogenetic band: 10q26.13HMX3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P124884: view genomic region
(about GC identifiers)
Start:
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124,895,478 bp from pter |
End:
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124,899,995 bp from pter |
Size:
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4,518 bases |
Orientation:
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plus strand |
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Proteins
for HMX3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HMX3_HUMAN, A6NHT5 (See
protein sequence)Recommended Name: Homeobox protein HMX3 Size: 357 amino acids; 37825 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: A8MU06Explore the universe of human proteins at neXtProt for HMX3: NX_A6NHT5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NHT5
HMX3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001099044.1
ENSEMBL proteins: ENSP00000350549
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
HMX3 for ontologies About GeneDecksing
HMX3 Antibody Products:
Assay Products for HMX3: |
Protein
Domains /
Families
for HMX3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HMX3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NHT5ProtoNet protein and cluster: A6NHT5 UniProtKB/Swiss-Prot: HMX3_HUMAN, A6NHT5Similarity: Belongs to the HMX homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Function
for HMX3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HMX3_HUMAN, A6NHT5Function: Transcription factor involved in specification of neuronal cell types and which is required for inner ear andhypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the innerear. Also required for hypothalamic/pituitary axis of the CNS (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMX3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMX3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HMX3 (NM_001105574) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMX3 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HMX3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
HMX3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for HMX3: Hmx3/Hmx2Hmx3/tm3Tlu Hmx3tm1Tlu Hmx3tm1Ebo
11 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Hmx3):
HMX3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HMX3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HMX3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for HMX3 (A6NHT53 ENSP000003505494) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
HMX3 for ontologies About GeneDecksing
|
Drugs & Compounds
for HMX3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HMX3
Search CenterWatch for drugs/clinical trials and news about HMX3
|
Transcripts
for HMX3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HMX3 gene: NM_001105574.1 Unigene Cluster for HMX3: H6 family homeobox 3 Hs.531194 [show with all ESTs]Unigene Representative Sequence: NM_0011055741 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000357878(uc010quc.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMX3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMX3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HMX3 (NM_001105574) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMX3 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HMX3 |
1 DOTS entry: DT.75192883 1 AceView cDNA sequence: AW088771
GeneLoc Exon Structure
|
Expression
for HMX3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HMX3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGCGGCGCA
About this image
See HMX3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.531194
SABiosciences Custom PCR Arrays for HMX3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMX3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HMX3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMX3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMX3 |
Orthologs
for HMX3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HMX3 gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HMX31 |
H6 family homeobox 3 |
80.83(n)
83.01(a) |
|
429199 NM_001007985.1 NP_001007986.1 |
lizard
(Anolis carolinensis) |
Reptilia |
HMX36 |
-- |
73(a) |
1 ↔ 1 |
3(60146678-60156467) |
African clawed frog
(Xenopus laevis) |
Amphibia |
nkx-5.1-A2 |
Nkx-5.1 homeodomain protein |
76.84(n) |
|
AF368235.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
hmx32 |
homeo box (H6 family) 3 |
76.79(n) |
|
60310 AF288211.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
NK7.16Hmx6 |
H6-like-homeobox |
7(a)15(a) |
possible ortholog1 ↔ many |
3R(10155862-10198673) 3R(13384652-13394126) |
worm
(Caenorhabditis elegans) |
Secernentea |
ceh-96mls-26 |
Homeobox protein ceh-9Mesodermal Lineage Specification family member (ml... |
26(a)17(a) |
possible ortholog1 ↔ many |
I(565439-566394) X(4758774-4761582) |
ENSEMBL Gene Tree for HMX3 (if available)
TreeFam Gene Tree for HMX3 (if available) |
Paralogs
for HMX3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HMX3 gene
- NKX2-32 TLX12 HMX22 NKX3-22 NKX2-82 NKX2-62 NKX2-12 NKX2-52
- NKX2-22 LBX12 NKX2-42 TLX32 HMX12 LBX22 TLX22 NKX3-12
2 SIMAP similar genes for HMX3 using alignment to 1 protein entry: HMX3_HUMAN:HMX1 HMX2
HMX3 for paralogs About GeneDecksing
|
Genomic Variants
for HMX3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HMX3 (124895478 - 124899995 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HMX3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMX3 |
|
Disorders
/ Diseases
for HMX3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HMX3 for disorders About GeneDecksing
OMIM gene information: 613380
OMIM disorders: --
2  diseases for HMX3: About MalaCardsstickler syndrome neuronitis
1 disease from the University of Copenhagen DISEASES database for HMX3:Stickler syndrome Export disorders for HMX3 gene to outside databases
|
Publications
for HMX3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HMX3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HMX3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Molecular (SNP) analyses of overlapping hemizygous de letions of 10q25.3 to 10qter in four patients: evidence for HMX2 and HMX3 as ca ndidate genes in hearing and vestibular function. (PubMed id 19253379)1 Miller N.D....Pevsner J. (2009)
- Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial ab normalities and reduced body mass. (PubMed id 19379485)9 Munroe R.J....Schimenti J.C. (2009)
- Cloning, characterization, and mapping of the mouse homeobox gene Hmx1. (PubMed id 9628823)9 Yoshiura K....Murray J.C. (1998)
|
External Searches for HMX3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing HMX3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HMX3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HMX3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HMX3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HMX3 gene:
Search GeneIP for patents involving HMX3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HMX3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HMX3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMX3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMX3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HMX3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMX3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMX3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HMX3 | | OriGene Custom Protein Services for HMX3 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HMX3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMX3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMX3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMX3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMX3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMX3 |
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| | | | Search Tocris compounds for HMX3 |
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 | | | HMX3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for HMX3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HMX3 |
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