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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HMX2 Gene

protein-coding   GIFtS: 45
GCID: GC10P124897

H6 Family Homeobox 2

(Previous name: homeo box (H6 family) 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
H6 Family Homeobox 21 2
Homeo Box (H6 Family) 21 2
Homeobox Protein H6 Family Member 22 3
H6L2
Nkx5-22
Homeobox Protein HMX22

External Ids:    HGNC: 50181   Entrez Gene: 31672   Ensembl: ENSG000001888167   OMIM: 6006475   UniProtKB: A2RU543   

Export aliases for HMX2 gene to outside databases

Previous GC identifers: GC10U990031 GC08M023560 GC10P124448 GC04M9P0040 GC10P118525


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HMX2 Gene:
The protein encoded by this gene is a member of the NKL homeobox family of transcription factors. Members in this
family are of ancient origin and play an important role in organ development during embryogenesis. A related
mouse protein plays a role in patterning of inner ear structures. In humans, variations in a region containing
this gene have been associated with inner ear malformations, vestibular dysfunction, and hearing loss. (provided
by RefSeq, Aug 2012)

GeneCards Summary for HMX2 Gene: 
HMX2 (H6 family homeobox 2) is a protein-coding gene. Diseases associated with HMX2 include peripartum cardiomyopathy, and split foot. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NKX2-1.

UniProtKB/Swiss-Prot: HMX2_HUMAN, A2RU54
Function: Transcription factor involved in specification of neuronal cell types and which is required for inner
ear and hypothalamus development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HMX2 gene promoter:
         p53   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHMX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HMX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.13

HMX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMX2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P124897:  view genomic region     (about GC identifiers)

Start:
124,907,638 bp from pter      End:
124,910,188 bp from pter
Size:
2,551 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HMX2_HUMAN, A2RU54 (See protein sequence)
Recommended Name: Homeobox protein HMX2  
Size: 273 amino acids; 29598 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B2RNV5

Explore the universe of human proteins at neXtProt for HMX2: NX_A2RU54

Explore proteomics data for HMX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A2RU54

  • HMX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HMX2 Protein Expression
    REFSEQ proteins: NP_005510.1  
    ENSEMBL proteins: 
     ENSP00000341108  

    Human Recombinant Protein Products for HMX2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HMX2
    GenScript Custom Purified and Recombinant Proteins Services for HMX2
    Novus Biologicals HMX2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HMX2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HMX2 for ontologies           About GeneDecksing



    HMX2 Antibody Products: 
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    Assay Products for HMX2: 
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    Cloud-Clone Corp. ELISAs for HMX2 
    Cloud-Clone Corp. CLIAs for HMX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NKL: Homeoboxes / ANTP class : NKL subclass

    4 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry A2RU54

    ProtoNet protein and cluster: A2RU54

    UniProtKB/Swiss-Prot: HMX2_HUMAN, A2RU54
    Similarity: Belongs to the HMX homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HMX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMX2_HUMAN, A2RU54
    Function: Transcription factor involved in specification of neuronal cell types and which is required for inner
    ear and hypothalamus development (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    HMX2 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hmx2):
     behavior/neurological  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  homeostasis/metabolism 
     mortality/aging  muscle  nervous system 

    HMX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hmx3/Hmx2Hmx3/tm3Tlu for HMX2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HMX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HMX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HMX2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HMX2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HMX2
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate HMX2 (see all 9):
    hsa-miR-33a* hsa-miR-4307 hsa-miR-466 hsa-miR-1260b hsa-miR-548c-3p hsa-miR-552 hsa-miR-1260 hsa-miR-1203
    SwitchGear 3'UTR luciferase reporter plasmidHMX2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HMX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMX2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of HMX2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HMX2 (see all 6)
    OriGene ORF clones in mouse, rat for HMX2
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    Sino Biological Human cDNA Clone for HMX2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMX2
    Sirion Biotech Customized lentivirus for stable overexpression of HMX2 
                         Customized lentivirus expression plasmids for stable overexpression of HMX2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HMX2
    Search LifeMap BioReagents cell lines for HMX2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMX2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HMX2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for HMX2 (A2RU543 ENSP000003411084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAMBPL1Q96FJ03, ENSP000003609924I2D: score=1 STRING: ENSP00000360992
    USP38Q8NB143, ENSP000003034344I2D: score=1 STRING: ENSP00000303434
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007420brain development IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0030154cell differentiation IEA--

    HMX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HMX2

    Search CenterWatch for drugs/clinical trials and news about HMX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HMX2 gene: 
    NM_005519.1  

    Unigene Cluster for HMX2:

    H6 family homeobox 2
    Hs.444756  [show with all ESTs]
    Unigene Representative Sequence: NM_005519
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000339992(uc001lhc.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HMX2
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate HMX2 (see all 9):
    hsa-miR-33a* hsa-miR-4307 hsa-miR-466 hsa-miR-1260b hsa-miR-548c-3p hsa-miR-552 hsa-miR-1260 hsa-miR-1203
    SwitchGear 3'UTR luciferase reporter plasmidHMX2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMX2
    Clone
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    OriGene ORF clones in mouse, rat for HMX2
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    GenScript: all cDNA clones in your preferred vector: HMX2 (NM_005519)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMX2
    Sirion Biotech Customized lentivirus for stable overexpression of HMX2 
                         Customized lentivirus expression plasmids for stable overexpression of HMX2 
    Primer
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    OriGene qPCR primer pairs and template standards for HMX2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMX2

    Additional mRNA sequence: 

    BC132758.1 BC137139.1 

    1 DOTS entry:

    DT.97788751 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HMX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATACACGCT
    HMX2 Expression
    About this image


    See HMX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HMX2

    SOURCE GeneReport for Unigene cluster: Hs.444756
        SABiosciences Custom PCR Arrays for HMX2
    Primer
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    OriGene qPCR primer pairs and template standards for HMX2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HMX2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmx21 , 5 H6 homeobox 21, 5 89.62(n)1
    93.77(a)1
      7 (74.34 cM)5
    153721  NM_145998.31  NP_666110.11 
     1315487735 
    chicken
    (Gallus gallus)
    Aves HMX21 H6 family homeobox 2 78.98(n)
    76.12(a)
      768405  XM_001231297.2  XP_001231298.2 
    lizard
    (Anolis carolinensis)
    Reptilia HMX26
    Uncharacterized protein
    68(a)
    1 ↔ 1
    3(60206108-60216841)
    zebrafish
    (Danio rerio)
    Actinopterygii hmx21 H6 family homeobox 2 64.37(n)
    67.82(a)
      555632  NM_001115098.1  NP_001108570.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NK7.16
    CG340316
    (see all 4)
    --
    7(a)
    20(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    3R(10155862-10198673)
    3L(23167567-23178791)
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-96
    ceh-196
    (see all 3)
    Homeobox protein ceh-19
    (see all 3)
    31(a)
    20(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    I(565436-566391)
    IV(7953509-7955898)


    ENSEMBL Gene Tree for HMX2 (if available)
    TreeFam Gene Tree for HMX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HMX2 gene
    NKX2-12  NKX6-12  HMX32  TLX22  NKX3-12  NKX2-32  TLX12  NKX6-32  
    NKX3-22  NKX6-22  NKX2-82  NKX2-62  NKX2-52  NKX2-22  NKX2-42  HMX12  
    TLX32  
    18/29 SIMAP similar genes for HMX2 using alignment to 2 protein entries:     HMX2_HUMAN (see all proteins) (see all similar genes):
    HOXB1    MSX1    GBX1    GBX2    MNX1    homeobox gene
    BARHL1    DLX1    DLX3    DLX6    HOXD1    NKX1-1
    NKX1-2    NKX2-6    NKX6-1    CDX1    CDX2    DBX2

    HMX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/104 SNPs in HMX2 are shown (see all 104)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461487831,2
    C--124905779(+) GCGCCA/GCCGCG 1 -- us2k10--------
    rs1906366151,2
    --124905804(+) GCACAA/CATTGT 1 -- us2k10--------
    rs1817750221,2
    --124905989(+) CCCTCG/TCCTGC 1 -- us2k10--------
    rs1863558071,2
    --124906097(+) CAGTCG/TGTAAC 1 -- us2k10--------
    rs1163675331,2
    F--124906174(+) AACTGC/TACAGT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1175783981,2
    C,F--124906175(+) ACTGCA/GCAGTC 1 -- us2k11Minor allele frequency- G:0.12EA 120
    rs1908591961,2
    --124906304(+) TCACAA/GCTTGA 1 -- us2k10--------
    rs796741561,2
    C,F--124906318(+) GACGGG/TGTTGC 1 -- us2k13Minor allele frequency- T:0.05CSA WA 122
    rs112484131,2
    C--124906353(+) CTTCAG/ATTTCC 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1996631611,2
    C--124906555(-) GGCTGG/TTNNNN 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HMX2 (124907638 - 124910188 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HMX2: --

    Human Gene Mutation Database (HGMD): HMX2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HMX2
    DNA2.0 Custom Variant and Variant Library Synthesis for HMX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600647    OMIM disorders: --

    6 diseases for HMX2:    About MalaCards
    peripartum cardiomyopathy    split foot    split hand    distal hereditary motor neuropathy
    neuropathy    neuronitis


    HMX2 for disorders           About GeneDecksing


    Export disorders for HMX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HMX2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with HMX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family. (PubMed id 7647458)1, 3 Stadler H.S.... Solursh M. (1995)
    2. Conservation of gene linkage in dispersed vertebrate N K homeobox clusters. (PubMed id 20072845)1 Wotton K.R....Lewis K.E. (2010)
    3. Molecular (SNP) analyses of overlapping hemizygous de letions of 10q25.3 to 10qter in four patients: evidence for HMX2 and HMX3 as ca ndidate genes in hearing and vestibular function. (PubMed id 19253379)1 Miller N.D....Pevsner J. (2009)
    4. A whole-genome scan for 24-hour respiration rate: a major locus at 10q26 influences respiration during sleep. (PubMed id 15558495)1 de Geus E.J....Boomsma D.I. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    8. Refined mapping of a gene for split hand-split foot malformation (SHFM3) on chromosome 10q25. (PubMed id 9004130)1 Raas-Rothschild A....Munnich A. (1996)
    9. A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development. (PubMed id 7510254)1 Bober E....Arnold H.H. (1994)
    10. Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial ab normalities and reduced body mass. (PubMed id 19379485)9 Munroe R.J....Schimenti J.C. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3167 HGNC: 5018 Ensembl:ENSG00000188816 euGenes: HUgn3167 ECgene: HMX2
    H-InvDB: HMX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HMX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HMX2 gene:
    Search GeneIP for patents involving HMX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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