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HMX2 Gene

protein-coding   GIFtS: 45
GCID: GC10P124897

H6 Family Homeobox 2

(Previous name: homeo box (H6 family) 2)
  See HMX2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
H6 Family Homeobox 21 2
Homeo Box (H6 Family) 21 2
Homeobox Protein H6 Family Member 22 3
H6L2
Nkx5-22
Homeobox Protein HMX22

External Ids:    HGNC: 50181   Entrez Gene: 31672   Ensembl: ENSG000001888167   OMIM: 6006475   UniProtKB: A2RU543   

Export aliases for HMX2 gene to outside databases

Previous GC identifers: GC10U990031 GC08M023560 GC10P124448 GC04M9P0040 GC10P118525


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HMX2 Gene:
The protein encoded by this gene is a member of the NKL homeobox family of transcription factors. Members in this
family are of ancient origin and play an important role in organ development during embryogenesis. A related
mouse protein plays a role in patterning of inner ear structures. In humans, variations in a region containing
this gene have been associated with inner ear malformations, vestibular dysfunction, and hearing loss. (provided
by RefSeq, Aug 2012)

GeneCards Summary for HMX2 Gene:
HMX2 (H6 family homeobox 2) is a protein-coding gene. Diseases associated with HMX2 include split foot, and split hand. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NKX2-1.

UniProtKB/Swiss-Prot: HMX2_HUMAN, A2RU54
Function: Transcription factor involved in specification of neuronal cell types and which is required for inner
ear and hypothalamus development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HMX2 gene promoter:
         p53   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHMX2 promoter sequence
   Search Chromatin IP Primers for HMX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.13

HMX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMX2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P124897:  view genomic region     (about GC identifiers)

Start:
124,907,638 bp from pter      End:
124,910,188 bp from pter
Size:
2,551 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HMX2_HUMAN, A2RU54 (See protein sequence)
Recommended Name: Homeobox protein HMX2  
Size: 273 amino acids; 29598 Da
Secondary accessions: B2RNV5

Explore the universe of human proteins at neXtProt for HMX2: NX_A2RU54

Explore proteomics data for HMX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HMX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005510.1  
    ENSEMBL proteins: 
     ENSP00000341108  

    HMX2 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for HMX2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NKL: Homeoboxes / ANTP class : NKL subclass

    4 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry A2RU54

    ProtoNet protein and cluster: A2RU54

    UniProtKB/Swiss-Prot: HMX2_HUMAN, A2RU54
    Similarity: Belongs to the HMX homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with HMX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMX2_HUMAN, A2RU54
    Function: Transcription factor involved in specification of neuronal cell types and which is required for inner
    ear and hypothalamus development (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with HMX2           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hmx2):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism 
     mortality/aging  muscle  nervous system 

    Find genes that share phenotypes with HMX2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hmx3/Hmx2Hmx3/tm3Tlu for HMX2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HMX2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HMX2
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    miRNA
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    Block miRNA regulation of human, mouse, rat HMX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HMX2 (see all 9):
    hsa-miR-33a* hsa-miR-4307 hsa-miR-466 hsa-miR-1260b hsa-miR-548c-3p hsa-miR-552 hsa-miR-1260 hsa-miR-1203
    SwitchGear 3'UTR luciferase reporter plasmidHMX2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HMX2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: HMX2 (NM_005519)
    Sino Biological Human cDNA Clone for HMX2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMX2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HMX2_HUMAN, A2RU54: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with HMX2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HMX2
    Interactions:

        Search GeneGlobe Interaction Network for HMX2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for HMX2 (A2RU543 ENSP000003411084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAMBPL1Q96FJ03, ENSP000003609924I2D: score=1 STRING: ENSP00000360992
    USP38Q8NB143, ENSP000003034344I2D: score=1 STRING: ENSP00000303434
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007420brain development IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with HMX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HMX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HMX2 gene: 
    NM_005519.1  

    Unigene Cluster for HMX2:

    H6 family homeobox 2
    Hs.444756  [show with all ESTs]
    Unigene Representative Sequence: NM_005519
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000339992(uc001lhc.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HMX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HMX2 (see all 9):
    hsa-miR-33a* hsa-miR-4307 hsa-miR-466 hsa-miR-1260b hsa-miR-548c-3p hsa-miR-552 hsa-miR-1260 hsa-miR-1203
    SwitchGear 3'UTR luciferase reporter plasmidHMX2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HMX2
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    GenScript: all cDNA clones in your preferred vector: HMX2 (NM_005519)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMX2
    Primer
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    OriGene qPCR primer pairs and template standards for HMX2
    OriGene qSTAR qPCR primer pairs in human, mouse for HMX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HMX2
      QuantiTect SYBR Green Assays in human, mouse, rat HMX2
      QuantiFast Probe-based Assays in human, mouse, rat HMX2

    Additional mRNA sequence: 

    BC132758.1 BC137139.1 

    1 DOTS entry:

    DT.97788751 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HMX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATACACGCT
    HMX2 Expression
    About this image

    HMX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444756
        Custom PCR Arrays for HMX2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HMX2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmx21 , 5 H6 homeobox 21, 5 89.62(n)1
    93.77(a)1
      7 (74.34 cM)5
    153721  NM_145998.31  NP_666110.11 
     1315487735 
    chicken
    (Gallus gallus)
    Aves HMX21 H6 family homeobox 2 78.23(n)
    75.75(a)
      768405  XM_001231297.3  XP_001231298.2 
    lizard
    (Anolis carolinensis)
    Reptilia HMX26
    H6 family homeobox 2
    68(a)
    1 ↔ 1
    3(60206108-60216841)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hmx21 H6 family homeobox 2 65.2(n)
    66(a)
      100486800  XM_002937803.2  XP_002937849.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmx21 H6 family homeobox 2 64.6(n)
    69.38(a)
      555632  NM_001115098.1  NP_001108570.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hmx6
    H6-like-homeobox
    16(a)
    1 → many
    3R(13384652-13394126)
    worm
    (Caenorhabditis elegans)
    Secernentea mls-26
    Protein MLS-2 (mls-2) mRNA, complete cds
    19(a)
    1 → many
    X(4758804-4761612) WBGene00003377


    ENSEMBL Gene Tree for HMX2 (if available)
    TreeFam Gene Tree for HMX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HMX2 gene
    NKX2-12  NKX6-12  HMX32  TLX22  NKX3-12  TLX12  NKX2-32  NKX6-32  
    NKX3-22  NKX6-22  NKX2-62  NKX2-82  NKX2-52  NKX2-22  NKX2-42  HMX12  
    TLX32  
    Selected SIMAP similar genes for HMX2 using alignment to 2 protein entries:     HMX2_HUMAN (see all proteins) (see all similar genes):
    HOXB1    MSX1    GBX1    GBX2    MNX1    homeobox gene
    BARHL1    DLX1    DLX3    DLX6    HOXD1    NKX1-1
    NKX1-2    NKX2-6    CDX1    DBX2    HOX2.8    NKX2-5

    Find genes that share paralogs with HMX2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HMX2 (see all 104)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461487831,2
    C--124905779(+) GCGCCA/GCCGCG 1 -- us2k10--------
    rs1906366151,2
    --124905804(+) GCACAA/CATTGT 1 -- us2k10--------
    rs1817750221,2
    --124905989(+) CCCTCG/TCCTGC 1 -- us2k10--------
    rs1863558071,2
    --124906097(+) CAGTCG/TGTAAC 1 -- us2k10--------
    rs1163675331,2
    F--124906174(+) AACTGC/TACAGT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1175783981,2
    C,F--124906175(+) ACTGCA/GCAGTC 1 -- us2k11Minor allele frequency- G:0.12EA 120
    rs1908591961,2
    --124906304(+) TCACAA/GCTTGA 1 -- us2k10--------
    rs796741561,2
    C,F--124906318(+) GACGGG/TGTTGC 1 -- us2k13Minor allele frequency- T:0.05CSA WA 122
    rs112484131,2
    C--124906353(+) CTTCAG/ATTTCC 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1996631611,2
    C--124906555(-) GGCTGG/TTNNNN 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HMX2 (124907638 - 124910188 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HMX2: --
    Human Gene Mutation Database (HGMD): HMX2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HMX2
    DNA2.0 Custom Variant and Variant Library Synthesis for HMX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600647    OMIM disorders: --

    2 diseases for HMX2:    
    About MalaCards
    split foot    split hand


    Find genes that share disorders with HMX2           About GenesLikeMe


    Export disorders for HMX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HMX2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with HMX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family. (PubMed id 7647458)1, 3 Stadler H.S.... Solursh M. (Mamm. Genome 1995)
    2. Conservation of gene linkage in dispersed vertebrate NK homeobox clusters. (PubMed id 20072845)1 Wotton K.R....Lewis K.E. (Dev. Genes Evol. 2010)
    3. Molecular (SNP) analyses of overlapping hemizygous deletions of 10q25.3 to 10qter in four patients: evidence for HMX2 and HMX3 as candidate genes in hearing and vestibular function. (PubMed id 19253379)1 Miller N.D....Pevsner J. (Am. J. Med. Genet. A 2009)
    4. A whole-genome scan for 24-hour respiration rate: a major locus at 10q26 influences respiration during sleep. (PubMed id 15558495)1 de Geus E.J....Boomsma D.I. (Am. J. Hum. Genet. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Refined mapping of a gene for split hand-split foot malformation (SHFM3) on chromosome 10q25. (PubMed id 9004130)1 Raas-Rothschild A....Munnich A. (J. Med. Genet. 1996)
    8. A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development. (PubMed id 7510254)1 Bober E....Arnold H.H. (Dev. Biol. 1994)
    9. (PubMed id )2 
    10. Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass. (PubMed id 19379485)9 Munroe R.J....Schimenti J.C. (BMC Dev. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3167 HGNC: 5018 Ensembl:ENSG00000188816 euGenes: HUgn3167 ECgene: HMX2
    H-InvDB: HMX2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HMX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HMX2 gene:
    Search GeneIP for patents involving HMX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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