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HMX1 Gene

protein-coding   GIFtS: 45
GCID: GC04M008847

H6 Family Homeobox 1

(Previous name: homeo box (H6 family) 1)
  See HMX1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
H6 Family Homeobox 11 2     NKX5-32
H62 3 5     H6 Homeodomain Protein2
Homeobox Protein H62 3     Homeobox Protein HMX12
Homeo Box (H6 Family) 11     

External Ids:    HGNC: 50171   Entrez Gene: 31662   Ensembl: ENSG000002156127   OMIM: 1429925   UniProtKB: Q9NP083   

Export aliases for HMX1 gene to outside databases

Previous GC identifers: GC04M021233 GC04M9E0039 GC00M9M0039 GC00M9V0039 GC04M9P0039 GC04M9R0039 GC04M008869


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HMX1 Gene:
This gene encodes a transcription factor that belongs to the H6 family of homeobox proteins. This protein can bind
a 5'-CAAG-3' core DNA sequence, and it is involved in the development of craniofacial structures. Mutations in
this gene cause oculoauricular syndrome, a disorder of the eye and external ear. (provided by RefSeq, Oct 2009)

GeneCards Summary for HMX1 Gene:
HMX1 (H6 family homeobox 1) is a protein-coding gene. Diseases associated with HMX1 include oculoauricular syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NKX2-1.

UniProtKB/Swiss-Prot: HMX1_HUMAN, Q9NP08
Function: DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional
repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development
of craniofacial structures such as the eye and ear




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006316.17  NC_018915.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for HMX1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HMX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

HMX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMX1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M008847:  view genomic region     (about GC identifiers)

Start:
8,847,802 bp from pter      End:
8,873,543 bp from pter
Size:
25,742 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HMX1_HUMAN, Q9NP08 (See protein sequence)
Recommended Name: Homeobox protein HMX1  
Size: 348 amino acids; 36155 Da
Sequence caution: Sequence=AAF70205.1; Type=Frameshift; Positions=35, 60, 84, 89, 157, 179, 277;

Explore the universe of human proteins at neXtProt for HMX1: NX_Q9NP08

Explore proteomics data for HMX1 at MOPED


See HMX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_061815.2  
ENSEMBL proteins: 
 ENSP00000446997   ENSP00000383516  

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antibodies-online proteins for HMX1 (4 products) 

 
antibodies-online peptides for HMX1

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antibodies-online antibodies for HMX1 (7 products) 

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antibodies-online kits for HMX1 (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
NKL: Homeoboxes / ANTP class : NKL subclass

4 InterPro protein domains:
 IPR020479 Homeobox_metazoa
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q9NP08

ProtoNet protein and cluster: Q9NP08

1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: HMX1_HUMAN, Q9NP08
Similarity: Belongs to the HMX homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with HMX1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HMX1_HUMAN, Q9NP08
Function: DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional
repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development
of craniofacial structures such as the eye and ear

     Genatlas biochemistry entry for HMX1:
Drosophila NK-3/NK-1 homolog,homeo domain encoding gene

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IMP10206974
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
Find genes that share ontologies with HMX1           About GenesLikeMe


Phenotypes:
     10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Hmx1):
 behavior/neurological  cellular  craniofacial  growth/size/body  hearing/vestibular/ear 
 mortality/aging  nervous system  no phenotypic analysis  skeleton  vision/eye 

Find genes that share phenotypes with HMX1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Hmx1tm1(KOMP)Vlcg for HMX1

   genOway: Develop your customized and physiologically relevant rodent model for HMX1

miRNA
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4 qRT-PCR Assays for microRNAs that regulate HMX1:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HMX1_HUMAN, Q9NP08: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol2
endoplasmic reticulum1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IC10206974

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HMX1
Interactions:

    Search GeneGlobe Interaction Network for HMX1

Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0007275multicellular organismal development IEA--
GO:0045892negative regulation of transcription, DNA-templated IMP10206974

Find genes that share ontologies with HMX1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HMX1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for HMX1 gene: 
NM_018942.2  

Unigene Cluster for HMX1:

H6 family homeobox 1
Hs.104134  [show with all ESTs]
Unigene Representative Sequence: NM_018942
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000506970 ENST00000400677(uc003izz.1)
miRNA
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4 qRT-PCR Assays for microRNAs that regulate HMX1:
hsa-miR-587 hsa-miR-204 hsa-miR-376a* hsa-miR-211
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HMX1
Predesigned siRNA for gene silencing in human, mouse, rat HMX1
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Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for HMX1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HMX1
  QuantiTect SYBR Green Assays in human, mouse, rat HMX1
  QuantiFast Probe-based Assays in human, mouse, rat HMX1

Additional mRNA sequence: 

AB593128.1 M99587.1 

5 DOTS entries:

DT.92325134  DT.40120531  DT.97793349  DT.92325135  DT.97792808 

9 AceView cDNA sequences:

AI201696 BM672288 BM701514 AI864453 BM700943 BM700983 M99587 NM_018942 
BF972930 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HMX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCACCCGGG
HMX1 Expression
About this image


HMX1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         nGnG Amacrine Cells Inner Nuclear Layer
         Retina
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Muscle Progenitor Cells Mandibular Arch Muscles
 
 Ovary (Reproductive System)
         Ovarian Somatic Cells Ovigerous Cord
 
 Adipose (Muscoskeletal System)
         Mesenchymal Stem Cells Subcutaneous White Adipose
 
 Neurons
         nGnG Amacrine Cells Inner Nuclear Layer
HMX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HMX1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.104134
    Custom PCR Arrays for HMX1
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QuantiFast Probe-based Assays in human, mouse, rat HMX1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMX1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for HMX1 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hmx11 , 5 H6 homeobox 11, 5 82.53(n)1
84.34(a)1
  5 (18.14 cM)5
153711  NM_010445.21  NP_034575.11 
 353888585 
chicken
(Gallus gallus)
Aves HMX16
Gallus gallus H6 family homeobox 1 (HMX1), mRNA.
59(a)
1 ↔ 1
4(80975027-80978215)
lizard
(Anolis carolinensis)
Reptilia --
--
--
79(a)
45(a)
1 ↔ many
1 ↔ many
GL343236.1(1933671-1943096)
GL343236.1(1943483-1955559)
zebrafish
(Danio rerio)
Actinopterygii LOC1003332981 homeobox protein HMX3-like 69.42(n)
69.42(a)
  100333298  XM_005169506.1  XP_005169563.1 
fruit fly
(Drosophila melanogaster)
Insecta Hmx6
H6-like-homeobox
20(a)
1 → many
3R(13384652-13394126)
worm
(Caenorhabditis elegans)
Secernentea ceh-276
Protein CEH-27, isoform b (ceh-27) mRNA, complete ...
22(a)
many ↔ many
V(11661553-11664697) WBGene00000449


ENSEMBL Gene Tree for HMX1 (if available)
TreeFam Gene Tree for HMX1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HMX1 gene
NKX2-12  NKX6-12  HMX32  TLX22  NKX3-12  TLX12  NKX2-32  HMX22  
NKX6-32  NKX3-22  NKX6-22  NKX2-62  NKX2-82  NKX2-52  NKX2-22  NKX2-42  
TLX32  
5 SIMAP similar genes for HMX1 using alignment to 2 protein entries:     HMX1_HUMAN (see all proteins):
HMX2    HOXB1    HOXA4    HMX3    RAX2

Find genes that share paralogs with HMX1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HMX1 (see all 127)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1810449551,2
C--8868347(+) AGCACA/GGTGGC 1 -- ds50010--------
rs1474354141,2
C--8868443(+) CAGCCA/GAGCCC 1 -- ds50010--------
rs1381805401,2
C--8868545(+) CCATCA/GTCACT 1 -- ds50010--------
rs1417369651,2
--8868555(+) TTCCTC/TCTCCC 1 -- ds50010--------
rs1872206951,2
--8868614(+) ACAGCA/GCTCAT 1 -- ds50010--------
rs1919771191,2
--8868676(+) CTCCAA/GGTGTC 1 -- ds50010--------
rs1835591901,2
--8868748(+) CTGCCC/TTCGTG 1 -- ds50010--------
rs1859334031,2
--8868817(+) TAGATC/TCATTT 1 -- ut310--------
rs11324561,2
C--8868848(+) GCTGCA/GACGTC 1 -- ut310--------
rs1395651921,2
C--8868936(+) CCGCGA/GGAGGG 1 -- ut310--------

HapMap Linkage Disequilibrium report for HMX1 (8847802 - 8873543 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for HMX1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv428437CNV Gain18775914
dgv1570e1CNV Complex17122850
dgv1569e1CNV Complex17122850

Human Gene Mutation Database (HGMD): HMX1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HMX1
DNA2.0 Custom Variant and Variant Library Synthesis for HMX1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 142992   
OMIM disorders: 612109  
UniProtKB/Swiss-Prot: HMX1_HUMAN, Q9NP08
  • Oculoauricular syndrome (OCLAUS) [MIM:612109]: A syndrome characterized by microphthalmia, microcornea,
    anterior segment dysgenesis, cataract, ocular coloboma, retinal pigment epithelium abnormalities, rod-cone
    dystrophy, and anomalies of the external ear. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 1 disease for HMX1:    
    About MalaCards
    oculoauricular syndrome

    3 diseases from the University of Copenhagen DISEASES database for HMX1:
    Diabetes mellitus     Hyperglycemia     maturity-onset diabetes of the young

    Find genes that share disorders with HMX1           About GenesLikeMe


    Export disorders for HMX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HMX1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with HMX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and genetic mapping of a homeobox gene to the 4p16.1 region of human chromosome 4. (PubMed id 1360670)1, 2, 3 Stadler H.S.... Solursh M. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Mutation in the human homeobox gene NKX5-3 causes an oculo-auricular syndrome. (PubMed id 18423520)1, 2 Schorderet D.F.... Munier F.L. (Am. J. Hum. Genet. 2008)
    3. Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA- binding site. (PubMed id 10206974)1, 2 Amendt B.A.... Russo A.F. (J. Biol. Chem. 1999)
    4. Retinal dystrophy in the oculo-auricular syndrome due to HMX1 mutation. (PubMed id 21417677)1 Vaclavik V....Munier F.L. (Ophthalmic Genet. 2011)
    5. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)
    6. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family. (PubMed id 7647458)1 Stadler H.S.... Solursh M. (Mamm. Genome 1995)
    10. Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass. (PubMed id 19379485)9 Munroe R.J....Schimenti J.C. (BMC Dev. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3166 HGNC: 5017 AceView: HMX1 Ensembl:ENSG00000215612 euGenes: HUgn3166
    ECgene: HMX1 H-InvDB: HMX1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HMX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HMX1 gene:
    Search GeneIP for patents involving HMX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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