Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HMSD Gene

protein-coding   GIFtS: 34
GCID: GC18P061616

Histocompatibility (Minor) Serpin Domain Containing


(Previous symbol: C18orf53)
  See HMSD-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Histocompatibility (Minor) Serpin Domain Containing1 2     ACC-62
C18orf531 2 3     Serpin-Like Protein HMSD2
Minor Histocompatibility Protein HMSD2 3     Minor Histocompatibility Serpin Domain-Containing Protein3
HSMD-v2 3     

External Ids:    HGNC: 230371   Entrez Gene: 2842932   Ensembl: ENSG000002218877   OMIM: 6120865   UniProtKB: P0C7T43   
UniProtKB: A8MTL93   
ORGUL members:         

Export aliases for HMSD gene to outside databases

Previous GC identifers: GC18P059768 GC18P058317


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HMSD Gene:
This gene encodes a serpin-domain containing protein that may function as a serine protease inhibitor. This gene
is primarily expressed in cells of myeloid lineage. A polymorphism in this gene may result in the expression a
splice variant that encodes a minor histocompatibility antigen. (provided by RefSeq, Oct 2010)

GeneCards Summary for HMSD Gene:
HMSD (histocompatibility (minor) serpin domain containing) is a protein-coding gene. Diseases associated with HMSD include hematopoietic stem cell transplantation. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot: HMSD_HUMAN, A8MTL9
Function: Putative serine protease inhibitor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the HMSD gene promoter:
         POU3F1   FOXO3   LCR-F1   FOXO3b   FOXL1   MEF-2A   POU2F1   POU2F1a   FOXO3a   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HMSD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMSD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.1   Ensembl cytogenetic band:  18q22.1   HGNC cytogenetic band: 18q21.33

HMSD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMSD gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P061616:  view genomic region     (about GC identifiers)

Start:
61,616,535 bp from pter      End:
61,649,008 bp from pter
Size:
32,474 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HMSDV_HUMAN, P0C7T4 (See protein sequence)
Recommended Name: Minor histocompatibility protein HMSD variant form  
Size: 53 amino acids; 6023 Da
Subunit: ACC-6 forms a complex with MHC HLA-B*4403
Caution: Translation of HMSD-v form generating mHA ACC-6 is in a frame different from that resulting in HMSD non
variant form expression. Thus, the HMSD non variant form sequence does not contain the mHA ACC-6 peptide
Alternative splicing: 2 isoforms:  P0C7T4-1   A8MTL9-1   (This alternative splicing event arises as a consequence of an intronic polymorphism)

UniProtKB/Swiss-Prot: HMSD_HUMAN, A8MTL9 (See protein sequence)

Recommended Name: Serpin-like protein HMSD precursor  
Size: 139 amino acids; 15355 Da
Caution: Translation of HMSD-v form generating mHA ACC-6 is in a frame different from that resulting in HMSD non
variant form expression. Thus, HMSD sequence described in this entry does not contain the mHA ACC-6 peptide
Alternative splicing: 2 isoforms:  A8MTL9-1   P0C7T4-1   (This alternative splicing event arises as a consequence of an intronic polymorphism)

Explore the universe of human proteins at neXtProt for HMSD: NX_A8MTL9

Explore proteomics data for HMSD at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn50

  • See HMSD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001116838.1  
    ENSEMBL proteins: 
     ENSP00000386207   ENSP00000431632  

    HMSD Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HMSD
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HMSD
    GenScript Custom Purified and Recombinant Proteins Services for HMSD
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HMSD

     
    Search eBioscience for Proteins for HMSD 

     
    antibodies-online proteins for HMSD 

     
    Search antibodies-online for peptides for HMSD

    HMSD Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HMSD
    Search for Antibodies for HMSD at Abcam
    Cloud-Clone Corp. Antibodies for HMSD
    Search ThermoFisher Antibodies for HMSD
    Search antibodies-online for antibodies for HMSD 

    HMSD Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HMSD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HMSD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HMSD
    Cloud-Clone Corp. CLIAs for HMSD
    Search eBioscience for ELISAs for HMSD 
    antibodies-online kits for HMSD (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR000215 Serpin_fam
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry P0C7T4
    Graphical View of Domain Structure for InterPro Entry A8MTL9

    ProtoNet protein and cluster: P0C7T4

    UniProtKB/Swiss-Prot: HMSD_HUMAN, A8MTL9
    Similarity: Belongs to the serpin family


    Find genes that share domains with HMSD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMSDV_HUMAN, P0C7T4
    Function: This allelic splice variant of HMSD is the precursor of the histocompatibility antigen ACC-6. More
    generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC,
    can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic
    intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides
    to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and
    thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation
    from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to
    mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. However, associated with
    GVHD, a favorable graft-versus-leukemia (GVL) can be induced by donor-recipient disparities in mHags. ACC-6 is
    presented to the cell surface by MHC HLA-B*4403. This complex specifically elicits donor-cytotoxic T-lymphocyte
    (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell
    recognition and lysis by CTL. Immunogenicity of most autosomal mHags results from single-nucleotide polymorphisms
    that cause amino-acid substitutions within epitopes, leading to the differential recognition of peptides between
    donor and recipient

         UniProtKB/Swiss-Prot: HMSD_HUMAN, A8MTL9
    Function: Putative serine protease inhibitor (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
         
    Find genes that share ontologies with HMSD           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HMSD

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HMSD using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HMSD
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HMSD
    Predesigned siRNA for gene silencing in human, mouse, rat HMSD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HMSD

    Clone
    Products:
         
    OriGene clones in human, mouse for HMSD (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HMSD (NM_001123366)
    Sino Biological Human cDNA Clone for HMSD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMSD
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HMSD

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HMSD
    Browse ESI BIO Cell Lines and PureStem Progenitors for HMSD 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMSD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HMSD_HUMAN, A8MTL9: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with HMSD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HMSD
    Interactions:

        Search GeneGlobe Interaction Network for HMSD

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HMSD



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HMSD gene: 
    NM_001123366.1  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000408945(uc010dqj.3) ENST00000481726 ENST00000526932 ENST00000498680

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HMSD using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HMSD
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HMSD
    Predesigned siRNA for gene silencing in human, mouse, rat HMSD
    Clone
    Products:
         
    OriGene clones in human, mouse for HMSD (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HMSD (NM_001123366)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMSD
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HMSD
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HMSD
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HMSD
      QuantiTect SYBR Green Assays in human, mouse, rat HMSD
      QuantiFast Probe-based Assays in human, mouse, rat HMSD

    Selected AceView cDNA sequences (see all 66):

    AL711105 BC034528 AA360401 CK904587 AA972628 NM_002640 CK904586 CB122815 
    NM_198833 BM696260 CF130399 BM991416 BQ003005 AI095851 BM054718 CD369662 
    BG499418 AI767324 W61361 AL121194 AW205887 BQ929418 BQ435307 BP364026 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HMSD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGCAAAGG
    HMSD Expression
    About this image

    HMSD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMSD Protein Expression

    UniProtKB/Swiss-Prot: HMSDV_HUMAN, P0C7T4
    Tissue specificity: Highly expressed in dendritic cells and primary leukemia cells, especially those of myeloid
    lineage. ACC-6 expression is limited to cells of the hematopoietic lineage

    UniProtKB/Swiss-Prot: HMSD_HUMAN, A8MTL9
    Tissue specificity: Highly expressed in dendritic cells and primary leukemia cells, especially those of myeloid
    lineage

        Custom PCR Arrays for HMSD
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HMSD
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HMSD
    QuantiTect SYBR Green Assays in human, mouse, rat HMSD
    QuantiFast Probe-based Assays in human, mouse, rat HMSD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMSD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of mammals.

    Orthologs for HMSD gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    platypus
    (Ornithorhynchus anatinus)
    Mammalia HMSD6
    histocompatibility (minor) serpin domain containin...
    17(a)
    1 ↔ 1
    Contig23495(1397-9581)


    ENSEMBL Gene Tree for HMSD (if available)
    TreeFam Gene Tree for HMSD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HMSD gene
    15 SIMAP similar genes for HMSD using alignment to 2 protein entries:     HMSDV_HUMAN (see all proteins):
    SERPINB6    SERPINB8    SERPINA2    SERPINB4    SERPINA3    SERPINA1
    SERPINA9    SERPINA6    SERPINB13    SERPINB10    SERPINB7    SERPINB5
    SERPINA5    SERPINB12    SERPINB11

    Find genes that share paralogs with HMSD           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    HMSDV_HUMAN, P0C7T4: Minor histocompatibility antigen ACC-6 (mHA ACC-6) is encoded by HMSD-v which is an allelic variant
    of HMSD. HMSD-v results from an intronic single-nucleotide polymorphism located at position 5 of HMSD intron 2
    leading to a G to A substitution. This variation in intron 2 induces skipping of exon 2 and frameshift, resulting
    in expression of ACC-6
    HMSD_HUMAN, A8MTL9: Minor histocompatibility antigen ACC-6 (mHA ACC-6) is encoded by HMSD-v which is an allelic variant
    of HMSD. HMSD-v results from an intronic single-nucleotide polymorphism located at position 5 of HMSD intron 2
    leading to a G to A substitution. This variation in intron 2 induces skipping of exon 2 and frameshift, resulting
    in expression of ACC-6


    Selected SNPs for HMSD (see all 295)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105718381,2
    C--58318270(+) GATAG-/TATGTTT 1 -- int10--------
    rs1129066661,2
    C--58324722(+) AAAAA-/ACAAACT 1 -- int11Minor allele frequency- AC:0.50CSA 2
    rs6856621,2
    C,F--58324723(-) AGTTTT/GTTTTT 1 -- int15Minor allele frequency- G:0.33NA WA CSA 9
    rs742570461,2
    C--61470708(+) AAACTC/GTAAAA 1 -- us2k12Minor allele frequency- G:0.18CSA EA 122
    rs1911408061,2
    --61470799(+) TAAAAA/CTGGGG 1 -- us2k10--------
    rs794371921,2
    C,F--61471015(+) CAAATT/CTGATA 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs797256091,2
    C,F--61471083(+) AGGAAA/GTAGAA 1 -- us2k12Minor allele frequency- G:0.19CSA WA 120
    rs1838674641,2
    --61471104(+) GGCCTA/GTATCT 1 -- us2k10--------
    rs751428861,2
    F--61471131(+) AATAAT/ATAATA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1406513741,2
    --61471183(+) AAATTA/CTAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HMSD (61616535 - 61649008 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HMSD:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv21739CNV Gain19812545
    nsv909693CNV Gain21882294
    nsv833673CNV Gain17160897

    Human Gene Mutation Database (HGMD): HMSD
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HMSD
    DNA2.0 Custom Variant and Variant Library Synthesis for HMSD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612086    OMIM disorders: --

    1 disease for HMSD:    
    About MalaCards
    hematopoietic stem cell transplantation


    Find genes that share disorders with HMSD           About GenesLikeMe


    Export disorders for HMSD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HMSD gene integrated from 10 sources:
    (articles sorted by number of sources associating them with HMSD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternative splicing due to an intronic SNP in HMSD generates a novel minor histocompatibility antigen. (PubMed id 17409267)1, 2, 3 Kawase T.... Takahashi T. (Blood 2007)
    2. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)1, 2 Nusbaum C.... Lander E.S. (Nature 2005)
    3. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1, 2 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 284293 HGNC: 23037 AceView: SERPINB8 Ensembl:ENSG00000221887 euGenes: HUgn284293
    ECgene: HMSD H-InvDB: HMSD

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HMSD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HMSD gene:
    Search GeneIP for patents involving HMSD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HMSD  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for HMSD  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HMSD  
     OriGene qSTAR qPCR primer pairs in human, mouse for HMSD   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HMSD   OriGene Custom Protein Services for HMSD  

     
     
     Block miRNA regulation of human, mouse, rat HMSD using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HMSD
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMSD Predesigned siRNA for gene silencing in human, mouse, rat HMSD
     QuantiFast Probe-based Assays in human, mouse, rat HMSD QuantiTect SYBR Green Assays in human, mouse, rat HMSD
     Custom PCR Arrays for HMSD Search Chromatin IP Primers for HMSD
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HMSD  Search GeneGlobe Interaction Network for HMSD
     Regulatory tfbs in HMSD promoter
     GenScript Custom Purified and Recombinant Proteins Services for HMSD GenScript cDNA clones with any tag delivered in your preferred vector for HMSD
     GenScript Custom Assay Services for HMSD GenScript Custom overexpressing Cell Line Services for HMSD
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HMSD
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for HMSD
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Search for Antibodies for HMSD at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HMSD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HMSD
     Antibodies for HMSD
     ELISAs for HMSD
     CLIAs for HMSD



     Browse ESI BIO Cell Lines and PureStem Progenitors for HMSD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMSD
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HMSD
     Browse SwitchGear Promoter luciferase reporter plasmids for HMSD
     Search ThermoFisher Antibodies for HMSD
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HMSD
     Browse compounds at ApexBio
     Search Addgene for plasmids for HMSD
      Search eBioscience for proteins for HMSD
      Search eBioscience for elisas for HMSD
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HMSD
      Search antibodies-online for antibodies for HMSD
     antibodies-online kits for HMSD (2 products)
      Search antibodies-online for peptides for HMSD
     antibodies-online proteins for HMSD
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HMSD gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4