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HMP19 Gene

protein-coding   GIFtS: 44
GCID: GC05P173405

HMP19 Protein


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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein P192 3     Neuron-Specific Protein Family Member 22
NSG22     P19 Protein2
HMP19 Protein2     Hmp193
Hypothalamus Golgi Apparatus Expressed 19 KDa Protein2     

External Ids:    Entrez Gene: 516172   Ensembl: ENSG000001700917   UniProtKB: Q9Y3283   

Export aliases for HMP19 gene to outside databases

Previous GC identifers: GC05P173730 GC05P174174 GC05P173408 GC05P173453 GC05P168568


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HMP19 Gene:
HMP19 is a protein-coding gene. GO annotations related to this gene include clathrin light chain binding. An important paralog of this gene is CALY.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the HMP19 gene promoter:
         Tal-1   MyoD   FOXD1   LCR-F1   E47   C/EBPalpha   SRY   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHMP19 promoter sequence
   Search Chromatin IP Primers for HMP19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMP19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   

HMP19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMP19 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P173405:  view genomic region     (about GC identifiers)

Start:
173,472,607 bp from pter      End:
173,670,504 bp from pter
Size:
197,898 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NSG2_HUMAN, Q9Y328 (See protein sequence)
Recommended Name: Neuron-specific protein family member 2  
Size: 171 amino acids; 19085 Da
Secondary accessions: B2R5Y0 D3DQN0 Q9UHX8

Explore the universe of human proteins at neXtProt for HMP19: NX_Q9Y328

Explore proteomics data for HMP19 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HMP19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057064.1  
    ENSEMBL proteins: 
     ENSP00000307722   ENSP00000427809   ENSP00000429689   ENSP00000429863   ENSP00000430208  
     ENSP00000431119  

    HMP19 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HMP19 

     
    antibodies-online proteins for HMP19 (4 products) 

     
    Search antibodies-online for peptides for HMP19

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    antibodies-online antibodies for HMP19 (19 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009431 Calcyon_neuron-sp

    Graphical View of Domain Structure for InterPro Entry Q9Y328

    ProtoNet protein and cluster: Q9Y328

    1 Blocks protein domain: IPB009431 D1 dopamine receptor-interacting

    UniProtKB/Swiss-Prot: NSG2_HUMAN, Q9Y328
    Similarity: Belongs to the NSG family


    Find genes that share domains with HMP19           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032051clathrin light chain binding IEA--
         
    Find genes that share ontologies with HMP19           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HMP19:
     Decreased viability of wild-ty 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HMP19

    miRNA
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    miRTarBase miRNAs that target HMP19:
    hsa-mir-335-5p (MIRT017340)

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    Selected qRT-PCR Assays for microRNAs that regulate HMP19 (see all 37):
    hsa-miR-142-5p hsa-miR-3685 hsa-miR-549 hsa-miR-19b-2* hsa-let-7a-2* hsa-miR-3613-3p hsa-miR-508-5p hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidHMP19 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HMP19

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NSG2_HUMAN, Q9Y328: Cytoplasmic vesicle membrane; Single-pass type II membrane protein (By similarity). Golgi
    apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity). Endosome, multivesicular
    body membrane; Single-pass type II membrane protein (By similarity). Note=Mainly Golgi stack, but also found in
    small vacuolar organelles and multivesicular bodies (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    golgi apparatus5
    cytosol2
    extracellular2
    peroxisome2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--
    GO:0032585multivesicular body membrane IEA--

    Find genes that share ontologies with HMP19           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HMP19
    Interactions:

        Search GeneGlobe Interaction Network for HMP19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for HMP19 (Q9Y3282, 3 ENSP000003077224) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCFC1R1Q9NWW02, 3, ENSP000002480894MINT-65807 I2D: score=3 STRING: ENSP00000248089
    STX18Q9P2W92, 3, ENSP000003058104MINT-65809 I2D: score=3 STRING: ENSP00000305810
    APOC1P026542, 3, ENSP000002524914MINT-8249025 I2D: score=2 STRING: ENSP00000252491
    NDUFA2O436782, 3, ENSP000002521024MINT-8263588 I2D: score=2 STRING: ENSP00000252102
    UCHL3P153742, 3, ENSP000003668194MINT-8276684 I2D: score=2 STRING: ENSP00000366819
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007212dopamine receptor signaling pathway IEA--
    GO:0048268clathrin coat assembly IEA--

    Find genes that share ontologies with HMP19           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HMP19 (NSG2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HMP19 gene: 
    NM_015980.4  

    Unigene Cluster for HMP19:

    HMP19 protein
    Hs.559412  [show with all ESTs]
    Unigene Representative Sequence: AK098398
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303177(uc003mcx.3 uc011dfh.2) ENST00000517902 ENST00000517587
    ENST00000519867 ENST00000521585 ENST00000521278 ENST00000519717 ENST00000521959
    ENST00000521146
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HMP19 (see all 37):
    hsa-miR-142-5p hsa-miR-3685 hsa-miR-549 hsa-miR-19b-2* hsa-let-7a-2* hsa-miR-3613-3p hsa-miR-508-5p hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidHMP19 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for HMP19
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HMP19
      QuantiTect SYBR Green Assays in human, mouse, rat HMP19
      QuantiFast Probe-based Assays in human, mouse, rat HMP19

    Additional mRNA sequence: 

    AF113537.1 AF123767.1 AF133422.1 AK098398.1 AK294383.1 AK295206.1 AK297196.1 AK312359.1 
    AK315949.1 AK315952.1 BC002619.2 BC018873.2 CR457142.1 

    11 DOTS entries:

    DT.40236081  DT.100820676  DT.100820682  DT.91670850  DT.100820672  DT.100681429  DT.100663203  DT.95199638 
    DT.100654056  DT.100829964  DT.92445643 

    Selected AceView cDNA sequences (see all 243):

    BX445014 D53115 BX460812 BI820363 CB155539 CB155533 AL537694 AA326317 
    BX419036 T33798 BE314360 BX418209 AL534735 T32091 BF516258 AL538105 
    D54712 AL532994 AI494598 AA780091 AA181324 CR626441 AL538218 CR596490 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HMP19    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                    -                                       
    SP2:                                                            
    SP3:                    -                                       



    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HMP19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HMP19 Expression
    About this image


    HMP19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             Caudate nucleus   
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
    HMP19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMP19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.559412
        Custom PCR Arrays for HMP19
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMP19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HMP19 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nsg21 , 5 neuron specific gene family member 21, 5 91.03(n)1
    97.08(a)1
      11 (18.72 cM)5
    181971  NM_008741.31  NP_032767.11 
     320004635 
    chicken
    (Gallus gallus)
    Aves LOC4162121 neuron-specific protein family member 2-like 76.22(n)
    83.04(a)
      416212  XM_001231713.3  XP_001231714.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    76(a)
    1 ↔ 1
    2(135706417-135785398)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hmp191 HMP19 protein 73.92(n)
    80(a)
      779643  NM_001078729.1  NP_001072197.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731422 hypothetical protein MGC73142 84.46(n)   393847  AY394975.1 


    ENSEMBL Gene Tree for HMP19 (if available)
    TreeFam Gene Tree for HMP19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HMP19 gene
    CALY2  NSG12  
    4 SIMAP similar genes for HMP19 using alignment to 5 protein entries:     E5RGE8_HUMAN (see all proteins):
    NSG2    D4S234E    NSG1    CALY

    Find genes that share paralogs with HMP19           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HMP19 (see all 1333)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs595338061,2
    --173470648(+) GTCTCG/TCTCTG 1 -- us2k10--------
    rs577551271,2
    C--173470831(+) AGGCTA/GGTCTC 1 -- us2k10--------
    rs1928804021,2
    --173470851(+) ACCTTA/GTGATC 1 -- us2k10--------
    rs1852297421,2
    --173470980(+) GGTATC/TAACCC 1 -- us2k10--------
    rs728147711,2
    C,F--173471004(+) TAGTTT/GGCAGA 1 -- us2k11Minor allele frequency- G:0.14NA 120
    rs1159048541,2
    F--173471178(+) ACAAGG/CGTTCA 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1412711111,2
    --173471377(+) AATGTC/TTCTCT 1 -- us2k10--------
    rs716131061,2
    C,F--173471400(+) ACACAC/TGTGTC 1 -- us2k14Minor allele frequency- T:0.22NA 126
    rs1400690441,2
    C--173471405(+) CGTGT-/CCCCCC 1 -- us2k10--------
    rs1901213111,2
    --173471452(+) ACTTAC/TGTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HMP19 (173472607 - 173670504 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HMP19:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731130CNV Deletion23290073
    esv990876CNV Deletion20482838
    esv2731129CNV Deletion23290073
    esv2731131CNV Deletion23290073
    esv1477078CNV Deletion17803354
    dgv113n17CNV Loss16327808
    nsv5137CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HMP19
    DNA2.0 Custom Variant and Variant Library Synthesis for HMP19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with HMP19           About GenesLikeMe

    Genetic Association Database (GAD): HMP19

    Export disorders for HMP19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HMP19 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with HMP19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    3. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)
    4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    5. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PubMed id 21130836)4 Luciano M....Deary I.J. (Biol Psychol 2011)
    6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. (PubMed id 15383276)1 Goehler H....Wanker E.E. (Mol. Cell 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51617 AceView: HMP19 Ensembl:ENSG00000170091 euGenes: HUgn51617

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HMP19 gene:
    Search GeneIP for patents involving HMP19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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