Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HMP19 Gene

Aliases for HMP19 Gene

  • HMP19 Protein 3 5
  • Protein P19 3 4
  • NSG2 3 4
  • Hypothalamus Golgi Apparatus Expressed 19 KDa Protein 3
  • Neuron-Specific Protein Family Member 2 3
  • P19 Protein 3
  • Hmp19 4

External Ids for HMP19 Gene

Previous GeneCards Identifiers for HMP19 Gene

  • GC05P173730
  • GC05P174174
  • GC05P173408
  • GC05P173453
  • GC05P173405
  • GC05P168568

Summaries for HMP19 Gene

GeneCards Summary for HMP19 Gene

HMP19 (HMP19 Protein) is a Protein Coding gene. GO annotations related to this gene include clathrin light chain binding. An important paralog of this gene is NSG1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMP19 Gene

Genomics for HMP19 Gene

Regulatory Elements for HMP19 Gene

Enhancers for HMP19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G173940 1.4 Ensembl ENCODE dbSUPER 19.7 -101.1 -101123 7.0 FOXA2 ATF1 MLX ARID4B DMAP1 SP5 JUNB PPARG KAT8 MIER3 HMP19 C5orf47 BOD1 ENSG00000253244 LINC01485 GC05M173953 CPEB4
GH05G174311 1.3 FANTOM5 Ensembl ENCODE 16.4 +266.3 266311 1.2 CTCF MXI1 RB1 BACH1 RAD21 ZNF121 ZFHX2 ARID3A PATZ1 ZNF143 HMP19 ENSG00000253244 BOD1 LOC102724551 ENSG00000249722 LOC105377737
GH05G173883 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -157.3 -157339 10.4 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D HMP19 CREBRF CPEB4 PIR46909
GH05G173788 1.5 Ensembl ENCODE dbSUPER 11.1 -255.8 -255830 2.9 PKNOX1 FOXA2 ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS ZNF263 ZNF202 HMP19 LOC100268168 LINC01485 LINC01484
GH05G173922 1.5 Ensembl ENCODE dbSUPER 9.9 -120.9 -120915 5.0 PKNOX1 FEZF1 ZNF2 ZNF121 KLF7 ZNF263 TSHZ1 REST TBX21 ZNF610 C5orf47 BOD1 HMP19 GC05M173953 CPEB4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HMP19 on UCSC Golden Path with GeneCards custom track

Genomic Location for HMP19 Gene

174,045,604 bp from pter
174,243,501 bp from pter
197,898 bases
Plus strand

Genomic View for HMP19 Gene

Genes around HMP19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMP19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMP19 Gene

Proteins for HMP19 Gene

  • Protein details for HMP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuron-specific protein family member 2
    Protein Accession:
    Secondary Accessions:
    • B2R5Y0
    • D3DQN0
    • Q9UHX8

    Protein attributes for HMP19 Gene

    171 amino acids
    Molecular mass:
    19085 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HMP19 Gene

Post-translational modifications for HMP19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMP19 Gene

No data available for DME Specific Peptides for HMP19 Gene

Domains & Families for HMP19 Gene

Protein Domains for HMP19 Gene

Suggested Antigen Peptide Sequences for HMP19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NSG family.
  • Belongs to the NSG family.
genes like me logo Genes that share domains with HMP19: view

No data available for Gene Families for HMP19 Gene

Function for HMP19 Gene

Gene Ontology (GO) - Molecular Function for HMP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032051 clathrin light chain binding IBA --
genes like me logo Genes that share ontologies with HMP19: view
genes like me logo Genes that share phenotypes with HMP19: view

Animal Model Products

CRISPR Products

miRNA for HMP19 Gene

miRTarBase miRNAs that target HMP19

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMP19 Gene

Localization for HMP19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMP19 Gene

Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Endosome, multivesicular body membrane; Single-pass type II membrane protein. Note=Mainly Golgi stack, but also found in small vacuolar organelles and multivesicular bodies. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HMP19 gene
Compartment Confidence
endosome 4
golgi apparatus 3
peroxisome 2
cytosol 2
plasma membrane 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HMP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with HMP19: view

Pathways & Interactions for HMP19 Gene

SuperPathways for HMP19 Gene

No Data Available

Interacting Proteins for HMP19 Gene

Gene Ontology (GO) - Biological Process for HMP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007212 dopamine receptor signaling pathway IEA --
GO:0016197 endosomal transport IBA --
GO:0048268 clathrin coat assembly IBA --
genes like me logo Genes that share ontologies with HMP19: view

No data available for Pathways by source and SIGNOR curated interactions for HMP19 Gene

Drugs & Compounds for HMP19 Gene

No Compound Related Data Available

Transcripts for HMP19 Gene

Unigene Clusters for HMP19 Gene

HMP19 protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMP19 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP3: -

Relevant External Links for HMP19 Gene

GeneLoc Exon Structure for

Expression for HMP19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HMP19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HMP19 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.8), Brain - Putamen (basal ganglia) (x6.8), Brain - Caudate (basal ganglia) (x6.6), Brain - Hypothalamus (x4.5), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for HMP19 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HMP19 Gene

Protein tissue co-expression partners for HMP19 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for HMP19 Gene:


Evidence on tissue expression from TISSUES for HMP19 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with HMP19: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMP19 Gene

Orthologs for HMP19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMP19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC462279 34
  • 100 (n)
-- 35
  • 100 (a)
(Canis familiaris)
Mammalia -- 35
  • 100 (a)
HMP19 34
  • 94.35 (n)
(Bos Taurus)
Mammalia NSG2 35
  • 99 (a)
HMP19 34
  • 93.76 (n)
(Mus musculus)
Mammalia Nsg2 34 16 35
  • 91.03 (n)
(Rattus norvegicus)
Mammalia Nsg2 34
  • 90.64 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
(Gallus gallus)
Aves -- 35
  • 78 (a)
LOC416212 34
  • 76.22 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hmp19 34
  • 73.92 (n)
(Danio rerio)
Actinopterygii hmp19 34 35
  • 72.9 (n)
zgc73142 34
Species where no ortholog for HMP19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMP19 Gene

Gene Tree for HMP19 (if available)
Gene Tree for HMP19 (if available)

Paralogs for HMP19 Gene

Paralogs for HMP19 Gene

(4) SIMAP similar genes for HMP19 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HMP19: view

Variants for HMP19 Gene

Sequence variations from dbSNP and Humsavar for HMP19 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000007583 -- 174,049,708(+) TGTGG(C/G)TCAAC intron-variant
rs1000012265 -- 174,089,415(+) GTGTA(-/T)TTTTT intron-variant, upstream-variant-2KB
rs1000025884 -- 174,076,022(+) CCTGA(A/G)CCCAG intron-variant
rs1000026386 -- 174,047,040(+) CCAAG(A/G)CATCT intron-variant
rs1000040007 -- 174,053,201(+) TACCT(C/T)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMP19 Gene

Variant ID Type Subtype PubMed ID
dgv113n17 CNV loss 16327808
esv1477078 CNV deletion 17803354
esv2731129 CNV deletion 23290073
esv2731130 CNV deletion 23290073
esv2731131 CNV deletion 23290073
esv3413399 CNV duplication 20981092
esv990876 CNV deletion 20482838
nsv5137 CNV deletion 18451855
nsv600298 CNV gain 21841781

Variation tolerance for HMP19 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HMP19 Gene

Disorders for HMP19 Gene

Relevant External Links for HMP19

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HMP19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMP19 Gene

Publications for HMP19 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64
  3. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3 64
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3 64
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3 64

Products for HMP19 Gene

Sources for HMP19 Gene

Loading form....