Aliases for HMP19 Gene
Aliases for HMP19 Gene
External Ids for HMP19 Gene
- Entrez Gene: 51617
- Ensembl: ENSG00000170091
- OMIM: 616752
- UniProtKB: Q9Y328
Previous GeneCards Identifiers for HMP19 Gene
- GC05P173730
- GC05P174174
- GC05P173408
- GC05P173453
- GC05P173405
- GC05P168568
Summaries for HMP19 Gene
GeneCards Summary for HMP19 Gene
HMP19 (HMP19 Protein) is a Protein Coding gene. GO annotations related to this gene include clathrin light chain binding. An important paralog of this gene is NSG1.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMP19 Gene
Genomics for HMP19 Gene
Regulatory Elements for HMP19 Gene
Enhancers for HMP19 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HMP19 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HMP19 gene promoter:
Regulatory Element Products
Genomic Location for HMP19 Gene
- Chromosome:
- 5
- Start:
- 174,045,604 bp from pter
- End:
- 174,243,501 bp from pter
- Size:
- 197,898 bases
- Orientation:
- Plus strand
Genomic View for HMP19 Gene
Genes around HMP19 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.2 by Ensembl
- 5q35.2 by Entrez Gene
HMP19 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMP19 Gene
Proteins for HMP19 Gene
-
Protein details for HMP19 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y328-NSG2_HUMAN
- Recommended name:
- Neuron-specific protein family member 2
- Protein Accession:
- Q9Y328
- B2R5Y0
- D3DQN0
- Q9UHX8
Protein attributes for HMP19 Gene
- Size:
- 171 amino acids
- Molecular mass:
- 19085 Da
- Quaternary structure:
- No Data Available
Protein Expression for HMP19 Gene
Post-translational modifications for HMP19 Gene
Other Protein References for HMP19 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HMP19
- Novus Biologicals Antibodies for HMP19
- Invitrogen Antibodies for HMP19
- GeneTex HMP19 antibody for HMP19
Protein Products
-
OriGene Purified Proteins for HMP19
- Search Origene for MassSpec and Protein Over-expression Lysates for HMP19
- Origene Custom Protein Services for HMP19
- Search GeneTex for Proteins for HMP19
Assay Products
No data available for DME Specific Peptides for HMP19 Gene
Domains & Families for HMP19 Gene
Protein Domains for HMP19 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMP19 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y328- Family:
-
- Belongs to the NSG family.
No data available for Gene Families for HMP19 Gene
Function for HMP19 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032051 | clathrin light chain binding | IBA | -- |
Phenotypes for HMP19 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HMP19 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMP19 gene
- Search ViGene Biosciences for HMP19
CRISPR Products
-
OriGene CRISPR knockouts for HMP19
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMP19
- GenScript: Design CRISPR guide RNA sequences for HMP19
miRNA for HMP19 Gene
- miRTarBase miRNAs that target HMP19
miRNA Products
- Search ViGene Biosciences for HMP19
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HMP19
- Browse OriGene Inhibitory RNA Products For HMP19
-
ViGene Biosciences ready-to-package AAV shRNAs for HMP19 gene
Clone Products
-
OriGene ORF clones in human for HMP19
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HMP19
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HMP19
-
ViGene Biosciences adenoviral particle packaged cDNA for HMP19 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HMP19 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMP19 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMP19 Gene
Localization for HMP19 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMP19 Gene
- Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Endosome, multivesicular body membrane; Single-pass type II membrane protein. Note=Mainly Golgi stack, but also found in small vacuolar organelles and multivesicular bodies. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| endosome | 4 |
| golgi apparatus | 3 |
| peroxisome | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005768 | endosome | IBA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IBA | -- |
| GO:0030659 | cytoplasmic vesicle membrane | IEA | -- |
Pathways & Interactions for HMP19 Gene
No Data Available
Interacting Proteins for HMP19 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007212 | dopamine receptor signaling pathway | IEA | -- |
| GO:0016197 | endosomal transport | IBA | -- |
| GO:0048268 | clathrin coat assembly | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HMP19 Gene
Transcripts for HMP19 Gene
mRNA/cDNA for HMP19 Gene
- (1) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (243) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HMP19
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMP19
- GenScript: Design CRISPR guide RNA sequences for HMP19
miRNA Products
- Search ViGene Biosciences for HMP19
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HMP19
- Browse OriGene Inhibitory RNA Products For HMP19
-
ViGene Biosciences ready-to-package AAV shRNAs for HMP19 gene
Clone Products
-
OriGene ORF clones in human for HMP19
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HMP19
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | - |
Relevant External Links for HMP19 Gene
- GeneLoc Exon Structure for
- HMP19
Expression for HMP19 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Endothelial Cells Blood Brain Barrier
- Hypothalamus
- Thalamus
- Amygdala
- Medulla Oblongata
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Neurons (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HMP19 Gene
This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.8), Brain - Putamen (basal ganglia) (x6.8), Brain - Caudate (basal ganglia) (x6.6), Brain - Hypothalamus (x4.5), and Brain - Anterior cingulate cortex (BA24) (x4.1).
This gene is overexpressed in Fetal Brain (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HMP19 Gene
- Elite partner
SOURCE GeneReport for Unigene cluster for HMP19 Gene:
Hs.559412Evidence on tissue expression from TISSUES for HMP19 Gene
- Nervous system(5)
Primer Products
-
OriGene qPCR primer pairs for HMP19
-
OriGene qPCR primer pairs and template standards for HMP19
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMP19 Gene
Orthologs for HMP19 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC462279 34 |
|
||
| -- 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToOne | |
| HMP19 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | NSG2 35 |
|
OneToOne | |
| HMP19 34 |
|
||||
| mouse (Mus musculus) |
Mammalia | Nsg2 16 35 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nsg2 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToOne | |
| LOC416212 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hmp19 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hmp19 34 35 |
|
||
| zgc73142 34 |
|
- Species where no ortholog for HMP19 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HMP19 Gene
(4) SIMAP similar genes for HMP19 Gene using alignment to 5 proteins:
Variants for HMP19 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000007583 | -- | 174,049,708(+) | TGTGG(C/G)TCAAC | intron-variant | |
| rs1000012265 | -- | 174,089,415(+) | GTGTA(-/T)TTTTT | intron-variant, upstream-variant-2KB | |
| rs1000025884 | -- | 174,076,022(+) | CCTGA(A/G)CCCAG | intron-variant | |
| rs1000026386 | -- | 174,047,040(+) | CCAAG(A/G)CATCT | intron-variant | |
| rs1000040007 | -- | 174,053,201(+) | TACCT(C/T)AGAGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv113n17 | CNV | loss | 16327808 |
| esv1477078 | CNV | deletion | 17803354 |
| esv2731129 | CNV | deletion | 23290073 |
| esv2731130 | CNV | deletion | 23290073 |
| esv2731131 | CNV | deletion | 23290073 |
| esv3413399 | CNV | duplication | 20981092 |
| esv990876 | CNV | deletion | 20482838 |
| nsv5137 | CNV | deletion | 18451855 |
| nsv600298 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.19;
4.21% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HMP19 Gene
Disorders for HMP19 Gene
Relevant External Links for HMP19
No disorders were found for HMP19 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMP19 Gene
Publications for HMP19 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64
- Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3 64
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3 64
- A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3 64
Products for HMP19 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Custom Antibody ServicesOriGene Antibodies for HMP19
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HMP19
- Search Origene for MassSpec and Protein Over-expression Lysates for HMP19
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- OriGene qPCR primer pairs and template standards for HMP19
- OriGene qPCR primer pairs for HMP19
- OriGene CRISPR knockouts for HMP19
- OriGene ORF clones in human for HMP19
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for HMP19 in any vector
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- GenScript: Design CRISPR guide RNA sequences for HMP19
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- Novus Biologicals Antibodies for HMP19
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- ViGene Biosciences adenoviral particle packaged cDNA for HMP19 gene
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- Horizon Cell Lines for HMP19
- Cyagen custom Knockout/knockin (KOKI) mouse models for HMP19
- VectorBuilder custom plasmid, inducible vectors for HMP19
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMP19
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HMP19 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer