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HMOX2 Gene

protein-coding   GIFtS: 73
GCID: GC16P004524

Heme Oxygenase (Decycling) 2

  See HMOX2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heme Oxygenase (Decycling) 21 2
HO-22 3
EC 1.14.99.33 8
Heme Oxygenase 22
HO23

External Ids:    HGNC: 50141   Entrez Gene: 31632   Ensembl: ENSG000001034157   OMIM: 1412515   UniProtKB: P305193   

Export aliases for HMOX2 gene to outside databases

Previous GC identifers: GC16P004549 GC16P004526 GC16P004466


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HMOX2 Gene:
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently
converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase
activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes,
an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase
family. Several alternatively spliced transcript variants encoding three different isoforms have been found for
this gene. (provided by RefSeq, Oct 2013)

GeneCards Summary for HMOX2 Gene:
HMOX2 (heme oxygenase (decycling) 2) is a protein-coding gene. Diseases associated with HMOX2 include pyloric stenosis, and hypertrophic pyloric stenosis. GO annotations related to this gene include heme oxygenase (decyclizing) activity. An important paralog of this gene is HMOX1.

UniProtKB/Swiss-Prot: HMOX2_HUMAN, P30519
Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is
subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme
oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2
could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter

summary for HMOX2 Gene:
Heme oxygenase (HO) catalyzes the degradation of heme. This membrane-bound enzyme cleaves the heme ring at
the alpha-methene bridge to produce bilverdin (which is metabolized further by bilirubin reductase to form
bilirubin), iron and the putative neurotransmitter, carbon monoxide. There are three isoforms of hem
oxygenase; the inducible HO-1, which is active at high concentrations of heme and at times of physiological
stress, the constitutively active HO-2 and the non-catalytic HO-3, which is thought to function as an oxygen
sensor. Hem oxygenase is localized to microsomes and the endoplasmic reticulum, and the enzyme is found at
very high concentrations in splenocytes due to their function in the degradation of senescent erythrocytes.

Gene Wiki entry for HMOX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010393.17  NT_187608.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the HMOX2 gene promoter:
         E2F-3a   E2F   E2F-1   E2F-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HMOX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMOX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

HMOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMOX2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P004524:  view genomic region     (about GC identifiers)

Start:
4,524,691 bp from pter      End:
4,560,348 bp from pter
Size:
35,658 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HMOX2_HUMAN, P30519 (See protein sequence)
Recommended Name: Heme oxygenase 2  
Size: 316 amino acids; 36033 Da
3 PDB 3D structures from and Proteopedia for HMOX2:
2Q32 (3D)        2QPP (3D)        2RGZ (3D)    
Secondary accessions: A8MT35 D3DUD5 O60605

Explore the universe of human proteins at neXtProt for HMOX2: NX_P30519

Explore proteomics data for HMOX2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys199
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HMOX2 (P30519) (see all 6)
     RIVEEAN  PVHDGKGD  YFPMELHRK  GDLSGGQVLKK 


    See HMOX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001120676.1  NP_001120677.1  NP_001120678.1  NP_001273196.1  NP_001273197.1  NP_001273198.1  NP_001273199.1  NP_001273200.1  
    NP_002125.3  

    ENSEMBL proteins: 
     ENSP00000458797   ENSP00000459214   ENSP00000394103   ENSP00000219700   ENSP00000460926  
     ENSP00000459445   ENSP00000461428   ENSP00000458824   ENSP00000458592   ENSP00000460992  
     ENSP00000381595   ENSP00000459203   ENSP00000385100   ENSP00000391637  
    Reactome Protein details: P30519

    HMOX2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for HMOX2 (HO-2/HMOX2)
    Enzo Life Sciences proteins for HMOX2
    OriGene Purified Protein for HMOX2
    OriGene Protein Over-expression Lysate for HMOX2
    OriGene MassSpec for HMOX2
    OriGene Custom Protein Services for HMOX2
    GenScript Custom Purified and Recombinant Proteins Services for HMOX2
    Novus Biologicals HMOX2 Proteins
    Novus Biologicals HMOX2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HMOX2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HMOX2 

    HMOX2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HMOX2 (HO-2/HMOX2)
    Cell Signaling Technology (CST) Antibodies for HMOX2 
    OriGene Antibodies for HMOX2
    OriGene Custom Antibody Services for HMOX2
    Novus Biologicals HMOX2 Antibodies
    Abcam antibodies for HMOX2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for HMOX2
    LSBio Antibodies in human, mouse, rat for HMOX2

    HMOX2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for HMOX2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HMOX2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Haem oxygenase 2
    Haem oxygenase

    4 InterPro protein domains:
     IPR016053 Haem_Oase-like
     IPR018207 Haem_oxygenase_CS
     IPR016084 Haem_Oase-like_multi-hlx
     IPR002051 Haem_Oase

    Graphical View of Domain Structure for InterPro Entry P30519

    ProtoNet protein and cluster: P30519

    1 Blocks protein domain: IPB002051 Heme oxygenase

    UniProtKB/Swiss-Prot: HMOX2_HUMAN, P30519
    Similarity: Belongs to the heme oxygenase family
    Similarity: Contains 2 HRM (heme regulatory motif) repeats


    Find genes that share domains with HMOX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMOX2_HUMAN, P30519
    Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is
    subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme
    oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2
    could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter
    Catalytic activity: Protoheme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O
    Induction: Heme oxygenase 2 activity is non-inducible

         Genatlas biochemistry entry for HMOX2:
    heme oxygenase-2,rate limiting enzyme in the degradation of heme to biliverdin,constitutive form,expressed in
    brain and testis,potent anti-inflammatory proteins whenever oxidation injury takes place

         Enzyme Number (IUBMB): EC 1.14.99.31 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004392heme oxygenase (decyclizing) activity IDA1575508
    GO:0005515protein binding IPI15528406
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with HMOX2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HMOX2:
     Decreased POU5F1-GFP protein e 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hmox2):
     behavior/neurological  cardiovascular system  digestive/alimentary  homeostasis/metabolism  integument 
     mortality/aging  muscle  nervous system  respiratory system 

    Find genes that share phenotypes with HMOX2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hmox2tm1Poss for HMOX2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HMOX2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HMOX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HMOX2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HMOX2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HMOX2:
    hsa-mir-186-5p (MIRT045117)

    Block miRNA regulation of human, mouse, rat HMOX2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate HMOX2:
    hsa-miR-224 hsa-miR-544b hsa-miR-3622b-3p hsa-miR-149 hsa-miR-4310 hsa-miR-3119 hsa-miR-338-3p hsa-miR-664*
    SwitchGear 3'UTR luciferase reporter plasmidHMOX2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HMOX2
    Predesigned siRNA for gene silencing in human, mouse, rat HMOX2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HMOX2

    Clone
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    OriGene clones in human, mouse for HMOX2 (see all 24)
    OriGene ORF clones in mouse, rat for HMOX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): HMOX2 (NM_002134)
    Sino Biological Human cDNA Clone for HMOX2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMOX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMOX2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HMOX2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMOX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HMOX2_HUMAN, P30519: Microsome. Endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    cytosol2
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane IDA15528406

    Find genes that share ontologies with HMOX2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HMOX2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of porphyrins
    Metabolism of porphyrins0.56
    Heme degradation0.00
    Porphyrin and chlorophyll metabolism0.56
    heme degradation0.00
    2Insulin receptor recycling
    Iron uptake and transport0.70
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    4Metabolism
    Metabolism0.38
    5Mineral absorption
    Mineral absorption


    Find genes that share SuperPaths with HMOX2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HMOX2
        Glucose / Energy Metabolism

    1 BioSystems Pathway for HMOX2
        heme degradation


    2 Reactome Pathways for HMOX2
        Heme degradation
    Iron uptake and transport


    2 Kegg Pathways  (Kegg details for HMOX2):
        Porphyrin and chlorophyll metabolism
    Mineral absorption

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HMOX2: 
              Nephrotoxicity in human mouse rat
              Cellular Stress Responses in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HMOX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HMOX2 (P305192, 3 ENSP000002197004) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIT1Q9Y2X72, 3MINT-8258277 MINT-63651 I2D: score=5 
    KIAA1377Q9P2H02, 3MINT-63650 MINT-8258335 I2D: score=5 
    HAP1P542572, 3MINT-8258288 MINT-63645 I2D: score=4 
    COPS6Q7L5N12, 3MINT-63648 I2D: score=5 
    EEF1GP266412, 3MINT-63644 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA15528406
    GO:0006778porphyrin-containing compound metabolic process TAS--
    GO:0006788heme oxidation IEA--
    GO:0006879cellular iron ion homeostasis TAS--
    GO:0006979response to oxidative stress IEA--

    Find genes that share ontologies with HMOX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HMOX2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Tin protoporphyrin IX dichlorideHeme oxygenase inhibitor[14325-05-4]

    8 HMDB Compounds for HMOX2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Biliverdin1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone (see all 7)114-25-0--
    Carbon monoxideCarbon monoxide (see all 2)124-38-9--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    FADH1,5-dihydro-FAD (see all 19)1910-41-4--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for HMOX2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--16986858 17157188

    Selected Novoseek inferred chemical compound relationships for HMOX2 gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    biliverdin 93.5 16 11909697 (2), 17887916 (1), 18689604 (1), 17522121 (1) (see all 14)
    zinc protoporphyrin 64.9 3 17179955 (1), 7907135 (1)
    copp 60.5 1 18334666 (1)
    snpp 60.4 1 9596945 (1)
    iron 58.6 9 17887916 (1), 19473966 (1), 9385081 (1), 16787441 (1) (see all 9)
    protoporphyrin ix 57.9 2 11554454 (1)
    cgmp 55.1 5 10487841 (1), 14527438 (1), 11502820 (1), 18712056 (1)
    nitric oxide 54.4 45 12395377 (4), 19106038 (3), 9141089 (2), 10332482 (2) (see all 20)
    guanylate 45.1 3 10487841 (1), 9476916 (1)
    haem 45.1 4 15777021 (1), 18412543 (1)



    Find genes that share compounds with HMOX2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HMOX2 gene (9 alternative transcripts): 
    NM_001127204.1  NM_001127205.1  NM_001127206.2  NM_001286267.1  NM_001286268.1  NM_001286269.1  NM_001286270.1  NM_001286271.1  
    NM_002134.3  

    Unigene Cluster for HMOX2:

    Heme oxygenase (decycling) 2
    Hs.284279  [show with all ESTs]
    Unigene Representative Sequence: BG115862
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575051 ENST00000570646(uc002cwq.4) ENST00000458134(uc002cwr.4)
    ENST00000219700 ENST00000575120 ENST00000572812 ENST00000574466 ENST00000576827
    ENST00000574594 ENST00000570445 ENST00000575129 ENST00000398595 ENST00000570622
    ENST00000406590(uc010bts.3) ENST00000414777(uc010btt.3 uc002cwt.3)

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    8 qRT-PCR Assays for microRNAs that regulate HMOX2:
    hsa-miR-224 hsa-miR-544b hsa-miR-3622b-3p hsa-miR-149 hsa-miR-4310 hsa-miR-3119 hsa-miR-338-3p hsa-miR-664*
    SwitchGear 3'UTR luciferase reporter plasmidHMOX2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HMOX2
    Predesigned siRNA for gene silencing in human, mouse, rat HMOX2
    Clone
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    OriGene clones in human, mouse for HMOX2 (see all 24)
    OriGene ORF clones in mouse, rat for HMOX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): HMOX2 (NM_002134)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMOX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMOX2
    Primer
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    OriGene qPCR primer pairs and template standards for HMOX2
    OriGene qSTAR qPCR primer pairs in human, mouse for HMOX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HMOX2
      QuantiTect SYBR Green Assays in human, mouse, rat HMOX2
      QuantiFast Probe-based Assays in human, mouse, rat HMOX2

    Additional mRNA sequence: 

    AF051306.1 AK093388.1 AK222629.1 AK313660.1 BC002396.2 BT019788.1 CR456760.1 CR541839.1 
    D21243.1 S34389.1 

    17 DOTS entries:

    DT.447203  DT.95247920  DT.97847622  DT.102833272  DT.91818079  DT.100815742  DT.92459619  DT.120676669 
    DT.100028569  DT.92459613  DT.100815734  DT.100815735  DT.102833271  DT.100680334  DT.40225253  DT.87046699 
    DT.100816267 

    Selected AceView cDNA sequences (see all 323):

    AU122603 BM923956 CR607350 CF128804 BE794645 BE464712 BM458087 AA456791 
    BU624090 CB128215 BX101805 BU163721 BU191713 BU507406 AI086057 BF220121 
    BF436319 BM704516 BU626748 CR614764 BU161966 AA621997 BE904847 AU106348 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HMOX2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10
    SP1:                          -     -     -     -                                                               
    SP2:                    -     -     -           -                                                               
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                    -     -     -     -     -     -     -     -                                             


    ECgene alternative splicing isoforms for HMOX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HMOX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACACCGGT
    HMOX2 Expression
    About this image


    HMOX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    HMOX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMOX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.284279
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HMOX2: 
              Nephrotoxicity in human mouse rat
              Cellular Stress Responses in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HMOX2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmox21 , 5 heme oxygenase (decycling) 21, 5 86.35(n)1
    89.21(a)1
      16 (2.46 cM)5
    153691  NM_001136066.21  NP_001129538.11 
     47263615 
    chicken
    (Gallus gallus)
    Aves HMOX21 heme oxygenase (decycling) 2 71.32(n)
    69.52(a)
      416663  XM_004945385.1  XP_004945442.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136772 Xenopus laevis transcribed sequence with moderate similarity more 73.05(n)    CD254609.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmox2a1 heme oxygenase (decycling) 2a 62.07(n)
    58.66(a)
      100002875  NM_001103139.1  NP_001096609.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ho6
    Heme oxygenase
    19(a)
    1 → many
    3R(7505481-7506698)


    ENSEMBL Gene Tree for HMOX2 (if available)
    TreeFam Gene Tree for HMOX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HMOX2 gene
    HMOX12  
    2 SIMAP similar genes for HMOX2 using alignment to 10 protein entries:     HMOX2_HUMAN (see all proteins):
    HO1    HMOX1

    Find genes that share paralogs with HMOX2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HMOX2 (see all 764)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871107511,2
    --4491596(+) GGCCCA/GGAGCG 2 -- us2k10--------
    rs1418214851,2
    --4527102(+) TTTACC/TTATTA 3 -- int10--------
    rs116399981,2
    C,F,A,H--4527109(+) ATTACC/TTTCTG 3 -- int120Minor allele frequency- T:0.28NS EA NA WA CSA 1152
    rs133340501,2
    C--4527252(+) tccagC/Gacttt 3 -- int10--------
    rs1828638711,2
    --4527265(+) GAGGCC/TAGGGC 3 -- int10--------
    rs1875392101,2
    C--4527468(+) GCACTC/GCAGCC 3 -- int10--------
    rs346727781,2
    C--4527566(+) GTCCA-/TCCTTA 3 -- int10--------
    rs1916595411,2
    --4527725(+) GATCAA/GCCTGG 3 -- int10--------
    rs561919191,2
    C--4527749(+) ACCCCA/GTCTCT 3 -- int10--------
    rs1848673681,2
    --4527788(+) GGGGTC/GGCGCG 3 -- int10--------

    HapMap Linkage Disequilibrium report for HMOX2 (4524691 - 4560348 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HMOX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv905224CNV Loss21882294
    esv23732CNV Gain19812545

    Human Gene Mutation Database (HGMD): HMOX2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HMOX2
    DNA2.0 Custom Variant and Variant Library Synthesis for HMOX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 141251    OMIM disorders: --

    6 diseases for HMOX2:    
    About MalaCards
    pyloric stenosis    hypertrophic pyloric stenosis    neonatal jaundice    gastroparesis
    adenomyosis    hirschsprung's disease


    Find genes that share disorders with HMOX2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HMOX2 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preeclampsia 43.7 6 19399816 (2), 11344084 (2), 14506930 (1), 15708121 (1)
    hirschsprung disease 32.9 3 12658761 (1), 12592623 (1)
    shock 22.1 8 12643617 (1), 12449621 (1), 17935786 (1), 8793113 (1) (see all 6)
    choriocarcinoma 17.1 1 14506930 (1)
    alzheimers disease 7.53 2 19246912 (1)
    cancer 4.4 1 17064313 (1)
    asthma 0 4 11069834 (3)
    cervical cancer 0 1 17064313 (1)
    bleeding 0 1 15377391 (1)
    necrosis 0 2 17761847 (1), 18334666 (1)

    Genetic Association Database (GAD): HMOX2
    Human Genome Epidemiology (HuGE) Navigator: HMOX2 (6 documents)

    Export disorders for HMOX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HMOX2 gene, integrated from 10 sources (see all 204):
    (articles sorted by number of sources associating them with HMOX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human heme oxygenase-2: characterization and expression of a full- length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal. (PubMed id 1575508)1, 2, 3, 9 McCoubrey W.K. Jr.... Maines M.D. (Arch. Biochem. Biophys. 1992)
    2. Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2. (PubMed id 7890772)1, 2, 9 Ishikawa K. (J. Biol. Chem. 1995)
    3. No genetic association between polymorphisms of heme oxygenase 1 and 2 and Alzheimer's disease in a Japanese population. (PubMed id 19246912)1, 4, 9 Shibata N....Arai H. (Dement Geriatr Cogn Disord 2009)
    4. Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population. (PubMed id 19886851)1, 4, 9 Yun L....Gu D. (Clin. Exp. Hypertens. 2009)
    5. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    6. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    7. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    8. Comparison of apo- and heme-bound crystal structures of a truncated human heme oxygenase-2. (PubMed id 17965015)1, 2 Bianchetti C.M.... Phillips G.N. Jr. (J. Biol. Chem. 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines. (PubMed id 17064313)1, 9 Ding Y....Shibahara S. (FEBS J. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3163 HGNC: 5014 AceView: HMOX2 Ensembl:ENSG00000103415 euGenes: HUgn3163
    ECgene: HMOX2 Kegg: 3163 H-InvDB: HMOX2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HMOX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HMOX2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hmox2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HMOX2 gene:
    Search GeneIP for patents involving HMOX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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