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Aliases for HMOX2 Gene

Aliases for HMOX2 Gene

  • Heme Oxygenase 2 2 3
  • Heme Oxygenase (Decycling) 2 2 3
  • EC 1.14.99.3 4 63
  • HO-2 3 4
  • HO2 4

External Ids for HMOX2 Gene

Previous GeneCards Identifiers for HMOX2 Gene

  • GC16P004549
  • GC16P004526
  • GC16P004466
  • GC16P004524

Summaries for HMOX2 Gene

Entrez Gene Summary for HMOX2 Gene

  • Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GeneCards Summary for HMOX2 Gene

HMOX2 (Heme Oxygenase 2) is a Protein Coding gene. Diseases associated with HMOX2 include hypertrophic pyloric stenosis and pyloric stenosis. Among its related pathways are Metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include heme oxygenase (decyclizing) activity. An important paralog of this gene is HMOX1.

UniProtKB/Swiss-Prot for HMOX2 Gene

  • Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter

Tocris Summary for HMOX2 Gene

  • Heme oxygenase (HO) catalyzes the degradation of heme. This membrane-bound enzyme cleaves the heme ring at the alpha-methene bridge to produce bilverdin (which is metabolized further by bilirubin reductase to form bilirubin), iron and the putative neurotransmitter, carbon monoxide. There are three isoforms of hem oxygenase; the inducible HO-1, which is active at high concentrations of heme and at times of physiological stress, the constitutively active HO-2 and the non-catalytic HO-3, which is thought to function as an oxygen sensor. Hem oxygenase is localized to microsomes and the endoplasmic reticulum, and the enzyme is found at very high concentrations in splenocytes due to their function in the degradation of senescent erythrocytes.

Gene Wiki entry for HMOX2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMOX2 Gene

Genomics for HMOX2 Gene

Regulatory Elements for HMOX2 Gene

Genomic Location for HMOX2 Gene

Start:
4,474,690 bp from pter
End:
4,510,347 bp from pter
Size:
35,658 bases
Orientation:
Plus strand

Genomic View for HMOX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMOX2 Gene

Proteins for HMOX2 Gene

  • Protein details for HMOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30519-HMOX2_HUMAN
    Recommended name:
    Heme oxygenase 2
    Protein Accession:
    P30519
    Secondary Accessions:
    • A8MT35
    • D3DUD5
    • I3L430
    • O60605

    Protein attributes for HMOX2 Gene

    Size:
    316 amino acids
    Molecular mass:
    36033 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=W38932; Type=Frameshift; Positions=82; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HMOX2 Gene

    Alternative splice isoforms for HMOX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMOX2 Gene

Proteomics data for HMOX2 Gene at MOPED

Selected DME Specific Peptides for HMOX2 Gene

Post-translational modifications for HMOX2 Gene

  • Ubiquitination at Lys199
  • Modification sites at PhosphoSitePlus

Domains for HMOX2 Gene

Gene Families for HMOX2 Gene

Protein Domains for HMOX2 Gene

Suggested Antigen Peptide Sequences for HMOX2 Gene

Graphical View of Domain Structure for InterPro Entry

P30519

UniProtKB/Swiss-Prot:

HMOX2_HUMAN :
  • P30519
Family:
  • Belongs to the heme oxygenase family.
Similarity:
  • Contains 2 HRM (heme regulatory motif) repeats.
genes like me logo Genes that share domains with HMOX2: view

Function for HMOX2 Gene

Molecular function for HMOX2 Gene

GENATLAS Biochemistry: heme oxygenase-2,rate limiting enzyme in the degradation of heme to biliverdin,constitutive form,expressed in brain and testis,potent anti-inflammatory proteins whenever oxidation injury takes place
UniProtKB/Swiss-Prot CatalyticActivity: Protoheme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O
UniProtKB/Swiss-Prot Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter
UniProtKB/Swiss-Prot Induction: Heme oxygenase 2 activity is non-inducible

Enzyme Numbers (IUBMB) for HMOX2 Gene

Gene Ontology (GO) - Molecular Function for HMOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004392 heme oxygenase (decyclizing) activity IDA 1575508
GO:0005515 protein binding IPI 15528406
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HMOX2: view
genes like me logo Genes that share phenotypes with HMOX2: view

Animal Models for HMOX2 Gene

MGI Knock Outs for HMOX2:

miRNA for HMOX2 Gene

miRTarBase miRNAs that target HMOX2

No data available for Transcription Factor Targeting and HOMER Transcription for HMOX2 Gene

Localization for HMOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMOX2 Gene

Microsome. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMOX2 Gene COMPARTMENTS Subcellular localization image for HMOX2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
cytosol 2
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HMOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane IDA 15528406
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HMOX2: view

Pathways for HMOX2 Gene

genes like me logo Genes that share pathways with HMOX2: view

Pathways by source for HMOX2 Gene

1 Cell Signaling Technology pathway for HMOX2 Gene
1 BioSystems pathway for HMOX2 Gene

Gene Ontology (GO) - Biological Process for HMOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 15528406
GO:0006778 porphyrin-containing compound metabolic process TAS --
GO:0006788 heme oxidation IEA --
GO:0006879 cellular iron ion homeostasis TAS --
GO:0006979 response to oxidative stress --
genes like me logo Genes that share ontologies with HMOX2: view

Compounds for HMOX2 Gene

(1) Tocris Compounds for HMOX2 Gene

Compound Action Cas Number
Tin protoporphyrin IX dichloride Heme oxygenase inhibitor [14325-05-4]

(8) HMDB Compounds for HMOX2 Gene

Compound Synonyms Cas Number PubMed IDs
Biliverdin
  • 1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone
114-25-0
Carbon monoxide
  • Carbon monoxide
124-38-9
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
FADH
  • 1,5-dihydro-FAD
1910-41-4
Heme
  • (protoporphyrinato)iron
14875-96-8

(1) Drugbank Compounds for HMOX2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target

(26) Novoseek inferred chemical compound relationships for HMOX2 Gene

Compound -log(P) Hits PubMed IDs
biliverdin 93.5 15
zinc protoporphyrin 64.9 2
copp 60.5 1
snpp 60.4 1
iron 58.6 9
genes like me logo Genes that share compounds with HMOX2: view

Transcripts for HMOX2 Gene

Unigene Clusters for HMOX2 Gene

Heme oxygenase (decycling) 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMOX2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5: - - - - - - - -
SP6: - - - -

Relevant External Links for HMOX2 Gene

GeneLoc Exon Structure for
HMOX2
ECgene alternative splicing isoforms for
HMOX2

Expression for HMOX2 Gene

mRNA expression in normal human tissues for HMOX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMOX2 Gene

SOURCE GeneReport for Unigene cluster for HMOX2 Gene Hs.284279

genes like me logo Genes that share expressions with HMOX2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HMOX2 Gene

Orthologs for HMOX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HMOX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMOX2 35
  • 99.68 (n)
  • 100 (a)
HMOX2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HMOX2 35
  • 86.18 (n)
  • 85.44 (a)
HMOX2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMOX2 35
  • 88.5 (n)
  • 90.19 (a)
HMOX2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmox2 35
  • 86.35 (n)
  • 89.21 (a)
Hmox2 16
Hmox2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HMOX2 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HMOX2 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmox2 35
  • 87.62 (n)
  • 89.84 (a)
chicken
(Gallus gallus)
Aves HMOX2 35
  • 71.32 (n)
  • 69.52 (a)
HMOX2 36
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13677 35
zebrafish
(Danio rerio)
Actinopterygii hmox2a 35
  • 62.07 (n)
  • 58.66 (a)
hmox2a 36
  • 54 (a)
OneToMany
hmox2b 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ho 36
  • 19 (a)
OneToMany
Species with no ortholog for HMOX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMOX2 Gene

ENSEMBL:
Gene Tree for HMOX2 (if available)
TreeFam:
Gene Tree for HMOX2 (if available)

Paralogs for HMOX2 Gene

Paralogs for HMOX2 Gene

Selected SIMAP similar genes for HMOX2 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with HMOX2: view

Variants for HMOX2 Gene

Sequence variations from dbSNP and Humsavar for HMOX2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs25685 -- 4,506,910(+) CTCTC(A/G)GAGCT synonymous-codon, reference
rs25686 -- 4,507,817(+) GAGCT(A/G)CACCG synonymous-codon, reference
rs1345430 -- 4,477,960(+) TTTGT(A/G)CTTAT intron-variant
rs1362626 -- 4,499,225(+) TTTGT(A/C/G)AAACA intron-variant
rs1362627 -- 4,501,504(+) TGATA(C/G)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMOX2 Gene

Variant ID Type Subtype PubMed ID
nsv905224 CNV Loss 21882294
esv23732 CNV Gain 19812545

Relevant External Links for HMOX2 Gene

HapMap Linkage Disequilibrium report
HMOX2
Human Gene Mutation Database (HGMD)
HMOX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMOX2 Gene

Disorders for HMOX2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (5) Diseases for HMOX2 Gene including...

Search for HMOX2 Gene in MalaCards »

(13) Novoseek inferred disease relationships for HMOX2 Gene

Disease -log(P) Hits PubMed IDs
preeclampsia 43.7 6
hirschsprung disease 32.9 2
shock 22.1 6
choriocarcinoma 17.1 1
alzheimers disease 7.53 1

Relevant External Links for HMOX2

Genetic Association Database (GAD)
HMOX2
Human Genome Epidemiology (HuGE) Navigator
HMOX2
genes like me logo Genes that share disorders with HMOX2: view

No data available for UniProtKB/Swiss-Prot for HMOX2 Gene

Publications for HMOX2 Gene

  1. Human heme oxygenase-2: characterization and expression of a full- length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal. (PMID: 1575508) McCoubrey W.K. Jr. … Maines M.D. (Arch. Biochem. Biophys. 1992) 2 3 4 23
  2. Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2. (PMID: 7890772) Ishikawa K. (J. Biol. Chem. 1995) 3 4 23
  3. No genetic association between polymorphisms of heme oxygenase 1 and 2 and Alzheimer's disease in a Japanese population. (PMID: 19246912) Shibata N. … Arai H. (Dement Geriatr Cogn Disord 2009) 3 23 48
  4. Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population. (PMID: 19886851) Yun L. … Gu D. (Clin. Exp. Hypertens. 2009) 3 23 48
  5. Enhanced translation of heme oxygenase-2 preserves human endothelial cell viability during hypoxia. (PMID: 20118244) He J.Z. … Ward M.E. (J. Biol. Chem. 2010) 3 23

Products for HMOX2 Gene

Sources for HMOX2 Gene

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