Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HMOX2 Gene

protein-coding GIFtS: 70
GCID: GC16P004524

heme oxygenase (decycling) 2

Explore 35 diseases affiliated with
HMOX2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heme Oxygenase (Decycling) 2¹ ²
HO-2¹ ² ³
EC 1.14.99.3³ ⁸
Heme Oxygenase 2²
HO2³

External Ids:	HGNC: 5014¹	Entrez Gene: 3163²	Ensembl: ENSG00000103415⁷	OMIM: 141251⁵	UniProtKB: P30519³

Export aliases for HMOX2 gene to outside databases

Previous GC identifers: GC16P004549 GC16P004526 GC16P004466

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HMOX2:

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently

converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase

activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an

inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.

Alternative splice variants encoding the same protein have been identified at this locus. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: HMOX2_HUMAN, P30519

Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is

subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme

oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2

could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter

summary for HMOX2:

Heme oxygenase (HO) catalyzes the degradation of heme. This membrane-bound enzyme cleaves the heme ring at

the alpha-methene bridge to produce bilverdin (which is metabolized further by bilirubin reductase to form

bilirubin), iron and the putative neurotransmitter, carbon monoxide. There are three isoforms of hem

oxygenase; the inducible HO-1, which is active at high concentrations of heme and at times of physiological

stress, the constitutively active HO-2 and the non-catalytic HO-3, which is thought to function as an oxygen

sensor. Hem oxygenase is localized to microsomes and the endoplasmic reticulum, and the enzyme is found at

very high concentrations in splenocytes due to their function in the degradation of senescent erythrocytes.

Gene Wiki entry for HMOX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HMOX2 gene promoter:
E2F-3a E2F E2F-1 E2F-2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for HMOX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMOX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

HMOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMOX2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P004524: view genomic region (about GC identifiers)

Start:	4,524,691 bp from pter	End:	4,560,348 bp from pter
Size:	35,658 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HMOX2_HUMAN, P30519 (See protein sequence)

Recommended Name: Heme oxygenase 2

Size: 316 amino acids; 36033 Da

Subcellular location: Microsome. Endoplasmic reticulum

3 PDB 3D structures from and Proteopedia for HMOX2:

2Q32 (3D)

2QPP (3D)

2RGZ (3D)

Secondary accessions: A8MT35 D3DUD5 O60605

Explore the universe of human proteins at neXtProt for HMOX2: NX_P30519

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P30519

4/6 DME Specific Peptides for HMOX2 (P30519) (see all 6)

RIVEEAN

PVHDGKGD

YFPMELHRK

GDLSGGQVLKK

HMOX2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001120676.1 NP_001120677.1 NP_001120678.1 NP_002125.3

ENSEMBL proteins:

ENSP00000458797 ENSP00000459214 ENSP00000394103 ENSP00000219700 ENSP00000460926

ENSP00000459445 ENSP00000461428 ENSP00000458824 ENSP00000458592 ENSP00000460992

ENSP00000381595 ENSP00000459203 ENSP00000385100 ENSP00000391637

Reactome Protein details: P30519
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant HMOX2 Protein
	R&D Systems Recombinant & Natural Proteins for HMOX2 (HO-2/HMOX2)
	Enzo Life Sciences proteins for HMOX2
	OriGene Purified Protein: HMOX2 OriGene Protein Over-expression Lysate (see all 4): HMOX2 OriGene Custom Protein Services for HMOX2
	GenScript Custom Purified and Recombinant Proteins Services for HMOX2
	Novus Biologicals HMOX2 Proteins Novus Biologicals HMOX2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for HMOX2
	Uscn Proteins for HMOX2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--
GO:0005886	plasma membrane	IDA	15528406

HMOX2 for ontologies About GeneDecksing

HMOX2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for HMOX2 (HO-2/HMOX2)
	Cell Signaling Technology (CST) Antibodies for HMOX2
	OriGene Antibodies (see all 9): HMOX2 OriGene Custom Antibody Services for HMOX2
	GenScript Custom Superior Antibodies Services for HMOX2
	Novus Biologicals HMOX2 Antibodies
	Search for Antibodies for HMOX2 at Abcam
	Uscn Antibodies for HMOX2
	ThermoFisher Antibodies for HMOX2

Assay Products for HMOX2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for HMOX2 (HO-2/HMOX2)
	GenScript Custom Assay Services for HMOX2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HMOX2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HMOX2 for domains About GeneDecksing

4 InterPro domains/families:

IPR016053 Haem_Oase-like

IPR018207 Haem_oxygenase_CS

IPR016084 Haem_Oase-like_multi-hlx

IPR002051 Haem_Oase

Graphical View of Domain Structure for InterPro Entry P30519

ProtoNet protein and cluster: P30519

1 Blocks protein family: IPB002051 Heme oxygenase

UniProtKB/Swiss-Prot: HMOX2_HUMAN, P30519

Similarity: Belongs to the heme oxygenase family

Similarity: Contains 2 HRM (heme regulatory motif) repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HMOX2_HUMAN, P30519

Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is

subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme

oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2

could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter

Catalytic activity: Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O

Induction: Heme oxygenase 2 activity is non-inducible

Genatlas biochemistry entry for HMOX2:

heme oxygenase-2,rate limiting enzyme in the degradation of heme to biliverdin,constitutive form,expressed in brain and

testis,potent anti-inflammatory proteins whenever oxidation injury takes place

Enzyme Number (IUBMB): EC 1.14.99.3¹ ²

miRNA Products:		OriGene 3'-UTR Clone (see all 4): HMOX2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HMOX2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate HMOX2:
		hsa-miR-224 hsa-miR-544b hsa-miR-3622b-3p hsa-miR-149 hsa-miR-4310 hsa-miR-3119 hsa-miR-338-3p hsa-miR-664*

		SwitchGear 3'UTR luciferase reporter plasmid: HMOX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMOX2 (see all 7) OriGene shRNA RFP: HMOX2 OriGene siRNA: HMOX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMOX2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HMOX2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMOX2 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMOX2 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): HMOX2 (NM_002134)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMOX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMOX2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HMOX2
		Search LifeMap BioReagents cell lines for HMOX2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMOX2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004392	heme oxygenase (decyclizing) activity	IDA	1575508
GO:0005515	protein binding	IPI	15528406
GO:0009055	electron carrier activity	--	--
GO:0046872	metal ion binding	IEA	--

HMOX2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for HMOX2:

Decreased POU5F1-GFP protein e

Animal Models:
Mouse knock-out Hmox2^tm1Poss for HMOX2
9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hmox2):

behavior/neurological	cardiovascular system	digestive/alimentary	homeostasis/metabolism	integument
mortality/aging	muscle	nervous system	respiratory system

HMOX2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

heme degradation

heme degradation

1.00

Heme degradation

0.80

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Metabolism

Metabolism

1.00

Mineral absorption

Mineral absorption

1.00

Insulin receptor recycling

Iron uptake and transport

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for HMOX2

Glucose / Energy Metabolism

1 BioSystems Pathway for HMOX2

heme degradation

5 Reactome Pathways for HMOX2

	Metabolism of porphyrins
	Transmembrane transport of small molecules
	Metabolism
	Heme degradation
	Iron uptake and transport

2 Kegg Pathways (Kegg details for HMOX2):

	Porphyrin and chlorophyll metabolism
	Mineral absorption

HMOX2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HMOX2

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/46 Interacting proteins for HMOX2 (P30519^{2, 3} ENSP00000219700⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GIT1	Q9Y2X7²^,³	MINT-8258277 MINT-63651 I2D: score=5
KIAA1377	Q9P2H0²^,³	MINT-63650 MINT-8258335 I2D: score=5
HAP1	P54257²^,³	MINT-8258288 MINT-63645 I2D: score=4
EIF3C	Q99613²^,³	MINT-8258266 I2D: score=2
EIF3CL	Q99613²^,³	MINT-8258266 I2D: score=2

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IDA	15528406
GO:0006778	porphyrin-containing compound metabolic process	TAS	--
GO:0006788	heme oxidation	IEA	--
GO:0006879	cellular iron ion homeostasis	TAS	--
GO:0006979	response to oxidative stress	IEA	--

HMOX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HMOX2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for HMOX2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Zinc protoporphyrin IX	Heme oxygenase and guanylyl cyclase inhibitor	[15442-64-5]
Tin protoporphyrin IX dichloride	Heme oxygenase inhibitor	[14325-05-4]

8 HMDB Compounds for HMOX2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Biliverdin	1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone (see all 7)	114-25-0	--
Carbon monoxide	Carbon monoxide (see all 2)	124-38-9	--
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
FADH	1,5-dihydro-FAD (see all 19)	1910-41-4	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

1 DrugBank Compound for HMOX2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
NADH	beta-DPNH (see all 18)	606-68-8	target	--	16986858 17157188

10/26 Novoseek chemical compound relationships for HMOX2 gene (see all 26) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
biliverdin	93.5	16	11909697 (2), 17887916 (1), 18689604 (1), 17522121 (1) (see all 14)
zinc protoporphyrin	64.9	3	17179955 (1), 7907135 (1)
copp	60.5	1	18334666 (1)
snpp	60.4	1	9596945 (1)
iron	58.6	9	17887916 (1), 19473966 (1), 9385081 (1), 16787441 (1) (see all 9)
protoporphyrin ix	57.9	2	11554454 (1)
cgmp	55.1	5	10487841 (1), 14527438 (1), 11502820 (1), 18712056 (1)
nitric oxide	54.4	45	12395377 (4), 19106038 (3), 9141089 (2), 10332482 (2) (see all 20)
guanylate	45.1	3	10487841 (1), 9476916 (1)
haem	45.1	4	15777021 (1), 18412543 (1)

Search CenterWatch for drugs/clinical trials and news about HMOX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HMOX2 gene (4 alternative transcripts):

NM_001127204.1 NM_001127205.1 NM_001127206.1 NM_002134.3

Unigene Cluster for HMOX2:

Heme oxygenase (decycling) 2

Hs.284279 [show with all ESTs]

Unigene Representative Sequence: BG115862

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000575051 ENST00000570646(uc002cwq.4) ENST00000458134(uc002cwr.4)

ENST00000219700 ENST00000575120 ENST00000572812 ENST00000574466 ENST00000576827

ENST00000574594 ENST00000570445 ENST00000575129 ENST00000398595 ENST00000570622

ENST00000406590(uc010bts.3) ENST00000414777(uc010btt.3 uc002cwt.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): HMOX2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HMOX2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate HMOX2:
		hsa-miR-224 hsa-miR-544b hsa-miR-3622b-3p hsa-miR-149 hsa-miR-4310 hsa-miR-3119 hsa-miR-338-3p hsa-miR-664*

		SwitchGear 3'UTR luciferase reporter plasmid: HMOX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMOX2 (see all 7) OriGene shRNA RFP: HMOX2 OriGene siRNA: HMOX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMOX2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMOX2 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMOX2 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): HMOX2 (NM_002134)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMOX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMOX2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMOX2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HMOX2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMOX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMOX2

Additional cDNA sequence:

AF051306.1 AK093388.1 AK222629.1 AK313660.1 BC002396.2 BT019788.1 CR456760.1 CR541839.1

D21243.1 S34389.1

17 DOTS entries:

DT.447203 DT.95247920 DT.97847622 DT.102833272 DT.91818079 DT.100815742 DT.92459619 DT.120676669

DT.100028569 DT.92459613 DT.100815734 DT.100815735 DT.102833271 DT.100680334 DT.40225253 DT.87046699

DT.100816267

24/323 AceView cDNA sequences (see all 323):

BG168102 BG679717 BU163721 AU106348 BM704516 BU626748 AA456791 BM555900

BM424122 BP350493 AW275981 BU191713 BM808405 BF436318 CF128804 CR600145

R72012 CD557641 BE794645 BG326396 BF436319 AA311325 BQ436017 BP349563

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HMOX2 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	·	8c	^	9	^	10
SP1:									-		-		-		-
SP2:							-		-		-				-
SP3:
SP4:
SP5:							-		-		-		-		-		-		-		-

ECgene alternative splicing isoforms for HMOX2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HMOX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACACCGGT

About this image
See HMOX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HMOX2

SOURCE GeneReport for Unigene cluster: Hs.284279

SABiosciences Expression via Pathway-Focused PCR Arrays including HMOX2:

Nephrotoxicity in human mouse rat

Cellular Stress Responses in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMOX2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HMOX2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMOX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMOX2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMOX2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HMOX2 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hmox2^{1 , 5}	heme oxygenase (decycling) 2^{1, 5}	86.35(n)¹ 89.21(a)¹		16 (2.46 cM)⁵ 15369¹ NM_001136066.2¹ NP_001129538.1¹ 4726361⁵
chicken (Gallus gallus)	Aves	HMOX2¹	heme oxygenase (decycling) 2	71.46(n) 69.97(a)		416663 XM_414960.2 XP_414960.1
African clawed frog (Xenopus laevis)	Amphibia	Xl.13677²	Xenopus laevis transcribed sequence with moderate similarity more	73.05(n)		CD254609.1
zebrafish (Danio rerio)	Actinopterygii	hmox2a¹	heme oxygenase (decycling) 2a	62.07(n) 58.66(a)		100002875 NM_001103139.1 NP_001096609.1
fruit fly (Drosophila melanogaster)	Insecta	Ho⁶	Heme oxygenase	18(a)	1 → many	3R(7505481-7506698)

ENSEMBL Gene Tree for HMOX2 (if available)
TreeFam Gene Tree for HMOX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HMOX2 gene

HMOX1²

2 SIMAP similar genes for HMOX2 using alignment to 10 protein entries: HMOX2_HUMAN (see all proteins):

HO1 HMOX1

HMOX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs13330134^1,2	C,F,	--	4494095(+)	`CTGTTT/GCCCGG`	1	--	us2k¹		2		WA NA	238
rs189157087^1,2		--	4522813(+)	`ATGCTA/GACTGA`	2	--	int¹ us2k¹		0	--	--	--	--
rs138842503^1,2		--	4522848(+)	`TATTAC/TGATTT`	2	--	int¹ us2k¹		0	--	--	--	--
rs192085751^1,2	C,	--	4522904(+)	`AGTAGA/TTTGGA`	2	--	us2k¹ int¹		0	--	--	--	--
rs115973061^1,2	F,	--	4523025(+)	`AGGCTG/TGAGTG`	2	--	us2k¹ int¹		1		WA	118
rs72768314^1,2	C,	--	4523091(+)	`CACCTC/TAACCT`	2	--	int¹ us2k¹		1		NA	120
rs79193705^1,2	C,	--	4523099(+)	`CCTCCT/CAGGTA`	2	--	int¹ us2k¹		3		WA NA	240
rs184689392^1,2		--	4523132(+)	`CCCCAA/CTAATT`	2	--	us2k¹ int¹		0	--	--	--	--
rs78538387^1,2	C,	--	4523167(+)	`ATTTTG/ACCCTG`	2	--	us2k¹ int¹		3		WA NA	240
rs188663557^1,2		--	4523201(+)	`CTCAGC/TTCAAG`	2	--	int¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HMOX2 (4524691 - 4560348 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HMOX2
1 CNV: 72438
Human Gene Mutation Database (HGMD): HMOX2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMOX2

DNA2.0 Custom Variant and Variant Library Synthesis for HMOX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HMOX2 for disorders           About GeneDecksing

OMIM gene information: 141251    OMIM disorders: --

20/35 diseases for HMOX2 (see all 35):    About MalaCards

spinal cord injury pyloric stenosis hypertrophic pyloric stenosis age related macular degeneration

congenital aphakia macular degeneration neonatal jaundice hirschsprung's disease

atrial fibrillation allergic rhinitis pleomorphic adenoma jaundice

gastroparesis varicocele liver cirrhosis rhinitis

renal cell carcinoma urethritis choriocarcinoma alzheimer's disease

1 disease from the University of Copenhagen DISEASES database for HMOX2:

Carbamoyl phosphate synthetase I deficiency disease

10/13 Novoseek disease relationships for HMOX2 gene (see all 13) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
preeclampsia	43.7	6	19399816 (2), 11344084 (2), 14506930 (1), 15708121 (1)
hirschsprung disease	32.9	3	12658761 (1), 12592623 (1)
shock	22.1	8	12643617 (1), 12449621 (1), 17935786 (1), 8793113 (1) (see all 6)
choriocarcinoma	17.1	1	14506930 (1)
alzheimers disease	7.53	2	19246912 (1)
cancer	4.4	1	17064313 (1)
asthma	0	4	11069834 (3)
cervical cancer	0	1	17064313 (1)
bleeding	0	1	15377391 (1)
necrosis	0	2	17761847 (1), 18334666 (1)

Human Genome Epidemiology (HuGE) Navigator: HMOX2 (6 documents)

Export disorders for HMOX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HMOX2 gene, integrated from 9 sources (see all 196):
(articles sorted by number of sources associating them with HMOX2)

Utopia: connect your pdf to the dynamic
world of online information

Human heme oxygenase-2: characterization and expression of a full- length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal. (PubMed id 1575508)^{1, 2, 3, 9} McCoubrey W.K. Jr.... Maines M.D. (1992)
Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2. (PubMed id 7890772)^{1, 2, 9} Ishikawa K. (1995)
Comparison of apo- and heme-bound crystal structures of a truncated human heme oxygenase-2. (PubMed id 17965015)^{1, 2} Bianchetti C.M.... Phillips G.N. Jr. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines. (PubMed id 17064313)^{1, 9} Ding Y....Shibahara S. (2006)
Heme regulatory motifs in heme oxygenase-2 form a thi ol/disulfide redox switch that responds to the cellular redox state. (PubMed id 19473966)^{1, 9} Yi L....Ragsdale S.W. (2009)
Enhanced translation of heme oxygenase-2 preserves hu man endothelial cell viability during hypoxia. (PubMed id 20118244)^{1, 9} He J.Z....Ward M.E. (2010)
Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies. (PubMed id 14506930)^{1, 9} Zenclussen A.C....Arck P.C. (2003)
A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytes. (PubMed id 19874887)^{1, 9} Zhong J.L....Tyrrell R.M. (2010)
Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. (PubMed id 15528406)^{1, 9} Williams S.E....Kemp P.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3163	HGNC: 5014	AceView: HMOX2	Ensembl:ENSG00000103415	euGenes: HUgn3163
ECgene: HMOX2	Kegg: 3163	H-InvDB: HMOX2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HMOX2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HMOX2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/hmox2/

Intellectual Property for HMOX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HMOX2 gene:
Search GeneIP for patents involving HMOX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	EMD Millipore Purified and/or Recombinant HMOX2 Protein
	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for HMOX2 (HO-2/HMOX2)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for HMOX2 (HO-2/HMOX2)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for HMOX2 (HO-2/HMOX2)

	OriGene Antibodies for HMOX2		OriGene shRNA RFP for HMOX2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMOX2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMOX2
	OriGene Protein Over-expression Lysate for HMOX2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HMOX2		OriGene 3'-UTR Clone for HMOX2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMOX2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMOX2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for HMOX2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HMOX2		OriGene Custom Protein Services for HMOX2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HMOX2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMOX2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMOX2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMOX2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMOX2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMOX2

	GenScript Custom Purified and Recombinant Proteins Services for HMOX2		GenScript cDNA clones with any tag delivered in your preferred vector for HMOX2
	GenScript Custom Assay Services for HMOX2		GenScript Custom Superior Antibodies Services for HMOX2
	GenScript Custom overexpressing Cell Line Services for HMOX2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for HMOX2

	Regulatory tfbs in HMOX2 promoter
	Search Chromatin IP Primers for HMOX2
	RT² qPCR Primer Assay in human, mouse, rat HMOX2
	GNC Network for HMOX2
	SABiosciences PCR Arrays including human, mouse, rat HMOX2

Tocris compounds for HMOX2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Proteins for HMOX2
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HMOX2 antibodies
	HMOX2 proteins
	HMOX2 lysates

	Search for Antibodies for HMOX2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for HMOX2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for HMOX2

HMOX2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HMOX2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMOX2

	SwitchGear 3'UTR luciferase reporter plasmids for HMOX2
	Browse SwitchGear Promoter luciferase reporter plasmids for HMOX2

ThermoFisher Antibodies for HMOX2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMOX2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HMOX2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

HMOX2 Gene

heme oxygenase (decycling) 2

Aliases
for HMOX2 gene

Summaries
for HMOX2 gene

Genomic Views
for HMOX2 gene

Proteins
for HMOX2 gene

Protein Domains /
Families
for HMOX2 gene

Function
for HMOX2 gene

Pathways & Interactions
for HMOX2 gene

Drugs & Compounds
for HMOX2 gene

Transcripts
for HMOX2 gene

Expression
for HMOX2 gene

Orthologs
for HMOX2 gene

Paralogs
for HMOX2 gene

Genomic Variants
for HMOX2 gene

Disorders / Diseases
for HMOX2 gene

Publications
for HMOX2 gene

External Searches for HMOX2 gene

Genome Databases showing HMOX2 gene

Other Databases showing HMOX2 gene

Specialized Databases showing HMOX2 gene

Intellectual Property
for HMOX2 gene

Products
for HMOX2 gene

View Random Gene

Advanced Search

Export list of displayed genes

HMOX2 Gene

heme oxygenase (decycling) 2

Aliasesfor HMOX2 gene

Summariesfor HMOX2 gene

Genomic Viewsfor HMOX2 gene

Proteinsfor HMOX2 gene

Protein Domains /Familiesfor HMOX2 gene

Functionfor HMOX2 gene

Pathways & Interactionsfor HMOX2 gene

Drugs & Compoundsfor HMOX2 gene

Transcriptsfor HMOX2 gene

Expression for HMOX2 gene

Orthologsfor HMOX2 gene

Paralogsfor HMOX2 gene

Genomic Variantsfor HMOX2 gene

Disorders / Diseasesfor HMOX2 gene

Publicationsfor HMOX2 gene

External Searches for HMOX2 gene

Genome Databases showing HMOX2 gene

Other Databases showing HMOX2 gene

Specialized Databases showing HMOX2 gene

Intellectual Propertyfor HMOX2 gene

Productsfor HMOX2 gene

View Random Gene

Aliases
for HMOX2 gene

Summaries
for HMOX2 gene

Genomic Views
for HMOX2 gene

Proteins
for HMOX2 gene

Protein Domains /
Families
for HMOX2 gene

Function
for HMOX2 gene

Pathways & Interactions
for HMOX2 gene

Drugs & Compounds
for HMOX2 gene

Transcripts
for HMOX2 gene

Expression
for HMOX2 gene

Orthologs
for HMOX2 gene

Paralogs
for HMOX2 gene

Genomic Variants
for HMOX2 gene

Disorders / Diseases
for HMOX2 gene

Publications
for HMOX2 gene

Intellectual Property
for HMOX2 gene

Products
for HMOX2 gene