Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HMOX2 Gene

Aliases for HMOX2 Gene

  • Heme Oxygenase 2 2 3 5
  • Heme Oxygenase (Decycling) 2 2 3
  • HO-2 3 4
  • EC 1.14.14.18 4
  • EC 1.14.99.3 61
  • HO2 4

External Ids for HMOX2 Gene

Previous GeneCards Identifiers for HMOX2 Gene

  • GC16P004549
  • GC16P004526
  • GC16P004466
  • GC16P004524

Summaries for HMOX2 Gene

Entrez Gene Summary for HMOX2 Gene

  • Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GeneCards Summary for HMOX2 Gene

HMOX2 (Heme Oxygenase 2) is a Protein Coding gene. Diseases associated with HMOX2 include Neonatal Jaundice and Glass Syndrome. Among its related pathways are Metabolism and Immune System. GO annotations related to this gene include heme oxygenase (decyclizing) activity. An important paralog of this gene is HMOX1.

UniProtKB/Swiss-Prot for HMOX2 Gene

  • Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Tocris Summary for HMOX2 Gene

  • Heme oxygenase (HO) catalyzes the degradation of heme. It is a membrane-bound enzyme that cleaves the heme ring at the alpha-methene bridge to produce bilverdin (which is metabolized further by bilirubin reductase to form bilirubin), iron and carbon monoxide.

Gene Wiki entry for HMOX2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMOX2 Gene

Genomics for HMOX2 Gene

Regulatory Elements for HMOX2 Gene

Enhancers for HMOX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F004499 1.2 Ensembl ENCODE 26.3 +28.8 28807 7.4 HDGF PKNOX1 WRNIP1 INSM2 SIN3A BMI1 FEZF1 ZNF2 RAD21 YY1 NMRAL1 HMOX2 CDIP1 PPL GC16P004506
GH16F004485 1.4 Ensembl ENCODE 15.4 +13.7 13702 6.2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 NMRAL1 CDIP1 HMOX2 CLUAP1 ZNF500 NUDT16L1 GLIS2 CORO7 MGRN1
GH16F004473 1.2 ENCODE 16 +1.5 1479 5.4 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 CBX5 NMRAL1 ZNF500 CREBBP CDIP1 HMOX2 NUDT16L1 MGRN1
GH16F004407 1.7 FANTOM5 Ensembl ENCODE 11 -62.2 -62154 10.2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 NMRAL1 VASN CORO7 HMOX2 MGRN1 NUDT16L1 CORO7-PAM16
GH16F004463 1 Ensembl ENCODE 16.9 -9.3 -9274 4.6 HDGF PKNOX1 ZNF140 ZNF335 ZNF121 POLR2A EED NFE2 ZSCAN29 ZNF600 NMRAL1 ZNF500 HMOX2 MGRN1 GC16M004469 GC16P004458
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HMOX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HMOX2 Gene

Chromosome:
16
Start:
4,474,690 bp from pter
End:
4,510,347 bp from pter
Size:
35,658 bases
Orientation:
Plus strand

Genomic View for HMOX2 Gene

Genes around HMOX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMOX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMOX2 Gene

Proteins for HMOX2 Gene

  • Protein details for HMOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30519-HMOX2_HUMAN
    Recommended name:
    Heme oxygenase 2
    Protein Accession:
    P30519
    Secondary Accessions:
    • A8MT35
    • D3DUD5
    • I3L430
    • O60605

    Protein attributes for HMOX2 Gene

    Size:
    316 amino acids
    Molecular mass:
    36033 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=W38932; Type=Frameshift; Positions=82; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HMOX2 Gene

    Alternative splice isoforms for HMOX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMOX2 Gene

Selected DME Specific Peptides for HMOX2 Gene

P30519:
  • PVHDGKGD
  • YFPMELHRK
  • PELLVAHAYTRY
  • GDLSGGQVLKK
  • FVKDFLKGNIKKE
  • RIVEEAN

Post-translational modifications for HMOX2 Gene

  • Ubiquitination at Lys 199
  • Modification sites at PhosphoSitePlus

Domains & Families for HMOX2 Gene

Gene Families for HMOX2 Gene

Protein Domains for HMOX2 Gene

Suggested Antigen Peptide Sequences for HMOX2 Gene

Graphical View of Domain Structure for InterPro Entry

P30519

UniProtKB/Swiss-Prot:

HMOX2_HUMAN :
  • Belongs to the heme oxygenase family.
  • Contains 2 HRM (heme regulatory motif) repeats.
Family:
  • Belongs to the heme oxygenase family.
Similarity:
  • Contains 2 HRM (heme regulatory motif) repeats.
genes like me logo Genes that share domains with HMOX2: view

Function for HMOX2 Gene

Molecular function for HMOX2 Gene

GENATLAS Biochemistry:
heme oxygenase-2,rate limiting enzyme in the degradation of heme to biliverdin,constitutive form,expressed in brain and testis,potent anti-inflammatory proteins whenever oxidation injury takes place
UniProtKB/Swiss-Prot CatalyticActivity:
Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = biliverdin + Fe(2+) + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O.
UniProtKB/Swiss-Prot Function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
UniProtKB/Swiss-Prot Induction:
Heme oxygenase 2 activity is non-inducible.

Enzyme Numbers (IUBMB) for HMOX2 Gene

Gene Ontology (GO) - Molecular Function for HMOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004392 heme oxygenase (decyclizing) activity IEA,TAS --
GO:0005515 protein binding IPI 15528406
GO:0016491 oxidoreductase activity IEA --
GO:0020037 heme binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HMOX2: view
genes like me logo Genes that share phenotypes with HMOX2: view

Animal Models for HMOX2 Gene

MGI Knock Outs for HMOX2:

Animal Model Products

  • Taconic Biosciences Mouse Models for HMOX2

miRNA for HMOX2 Gene

miRTarBase miRNAs that target HMOX2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HMOX2 Gene

Localization for HMOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMOX2 Gene

Microsome. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HMOX2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
cytosol 4
mitochondrion 2
nucleus 2
extracellular 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HMOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane IDA 15528406
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HMOX2: view

Pathways & Interactions for HMOX2 Gene

genes like me logo Genes that share pathways with HMOX2: view

Pathways by source for HMOX2 Gene

1 Cell Signaling Technology pathway for HMOX2 Gene
1 BioSystems pathway for HMOX2 Gene

Gene Ontology (GO) - Biological Process for HMOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 15528406
GO:0006788 heme oxidation IEA,IBA --
GO:0006879 cellular iron ion homeostasis TAS --
GO:0006979 response to oxidative stress IEA,IBA --
GO:0042167 heme catabolic process TAS --
genes like me logo Genes that share ontologies with HMOX2: view

No data available for SIGNOR curated interactions for HMOX2 Gene

Drugs & Compounds for HMOX2 Gene

(26) Drugs for HMOX2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Carbon monoxide Approved Pharma 116
FAD Approved Pharma 0
Water Approved Pharma 0
Stannsoporfin Investigational Pharma inhibitor, Target 0

(13) Additional Compounds for HMOX2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
biliverdin
  • Biliverdin IX
  • 1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone
  • Biliverdin IX alpha
  • Biliverdine
  • Dehydrobilirubin
114-25-0
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
FADH
  • 1,5-Dihydro-FAD
  • 1,5-Dihydro-P-5-ester with adenosine
  • 1,5-Dihydro-Riboflavin 5'-(trihydrogen diphosphate) P'->5'-ester with adenosine
  • Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with 5,10-dihydro-7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)alloxazine
  • Adenosine 5'-(trihydrogen pyrophosphate), 5'->5'-ester with 5,10-dihydro-7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)alloxazine
1910-41-4
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Fe3+
  • Fe(III)
  • Ferric ion
  • Iron(3+)
7439-89-6

(1) Tocris Compounds for HMOX2 Gene

Compound Action Cas Number
Tin protoporphyrin IX dichloride Heme oxygenase inhibitor 14325-05-4

(4) ApexBio Compounds for HMOX2 Gene

Compound Action Cas Number
Bifemelane hydrochloride 62232-46-6
Lazabemide hydrochloride 103878-83-7
Tin protoporphyrin IX dichloride 14325-05-4
Zinc protoporphyrin IX 15442-64-5
genes like me logo Genes that share compounds with HMOX2: view

Transcripts for HMOX2 Gene

Unigene Clusters for HMOX2 Gene

Heme oxygenase (decycling) 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMOX2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5: - - - - - - - -
SP6: - - - -

Relevant External Links for HMOX2 Gene

GeneLoc Exon Structure for
HMOX2
ECgene alternative splicing isoforms for
HMOX2

Expression for HMOX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HMOX2 Gene

Protein differential expression in normal tissues from HIPED for HMOX2 Gene

This gene is overexpressed in Bone (18.9) and Nasal epithelium (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMOX2 Gene



Protein tissue co-expression partners for HMOX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HMOX2 Gene:

HMOX2

SOURCE GeneReport for Unigene cluster for HMOX2 Gene:

Hs.284279
genes like me logo Genes that share expression patterns with HMOX2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HMOX2 Gene

Orthologs for HMOX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HMOX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMOX2 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia HMOX2 34 35
  • 88.5 (n)
rat
(Rattus norvegicus)
Mammalia Hmox2 34
  • 87.62 (n)
mouse
(Mus musculus)
Mammalia Hmox2 34 16 35
  • 86.35 (n)
cow
(Bos Taurus)
Mammalia HMOX2 34 35
  • 86.18 (n)
oppossum
(Monodelphis domestica)
Mammalia HMOX2 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HMOX2 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves HMOX2 34 35
  • 71.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13677 34
zebrafish
(Danio rerio)
Actinopterygii hmox2a 34 35
  • 62.07 (n)
hmox2b 35
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ho 35
  • 19 (a)
OneToMany
Species where no ortholog for HMOX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMOX2 Gene

ENSEMBL:
Gene Tree for HMOX2 (if available)
TreeFam:
Gene Tree for HMOX2 (if available)

Paralogs for HMOX2 Gene

Paralogs for HMOX2 Gene

genes like me logo Genes that share paralogs with HMOX2: view

Variants for HMOX2 Gene

Sequence variations from dbSNP and Humsavar for HMOX2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10500325 -- 4,503,191(+) GCTTA(C/T)TCTAC intron-variant
rs1051308 -- 4,510,300(+) CCTCC(A/G)CGCTG downstream-variant-500B, utr-variant-3-prime
rs11076833 -- 4,479,000(+) AAATA(A/C)AAAAA intron-variant
rs11076834 -- 4,499,582(+) CTGAT(C/G)ATCTG intron-variant
rs11076835 -- 4,499,617(+) AATAT(A/G)GTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMOX2 Gene

Variant ID Type Subtype PubMed ID
nsv1160332 CNV duplication 26073780
nsv1071256 CNV deletion 25765185
nsv1046986 CNV gain 25217958
esv23732 CNV gain 19812545

Variation tolerance for HMOX2 Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HMOX2 Gene

Human Gene Mutation Database (HGMD)
HMOX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HMOX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMOX2 Gene

Disorders for HMOX2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for HMOX2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neonatal jaundice
  • neonatal hyperbilirubinemia
glass syndrome
  • chromosome 2q32-q33 deletion syndrome
nodular malignant melanoma
  • nodular melanoma
carbamoylphosphate synthetase i deficiency
  • carbamoyl phosphate synthetase i deficiency, hyperammonemia due to
hypertrophic pyloric stenosis
  • congenital hypertrophic pyloric stenosis
- elite association - COSMIC cancer census association via MalaCards
Search HMOX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HMOX2

Genetic Association Database (GAD)
HMOX2
Human Genome Epidemiology (HuGE) Navigator
HMOX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HMOX2
genes like me logo Genes that share disorders with HMOX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HMOX2 Gene

Publications for HMOX2 Gene

  1. Human heme oxygenase-2: characterization and expression of a full- length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal. (PMID: 1575508) McCoubrey W.K. Jr. … Maines M.D. (Arch. Biochem. Biophys. 1992) 2 3 4 22 64
  2. No genetic association between polymorphisms of heme oxygenase 1 and 2 and Alzheimer's disease in a Japanese population. (PMID: 19246912) Shibata N. … Arai H. (Dement Geriatr Cogn Disord 2009) 3 22 46 64
  3. Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population. (PMID: 19886851) Yun L. … Gu D. (Clin. Exp. Hypertens. 2009) 3 22 46 64
  4. Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2. (PMID: 7890772) Ishikawa K. (J. Biol. Chem. 1995) 3 4 22 64
  5. A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytes. (PMID: 19874887) Zhong J.L. … Tyrrell R.M. (Free Radic. Biol. Med. 2010) 3 22 64

Products for HMOX2 Gene

  • Cloud-Clone Corp. Antibodies for HMOX2
  • Cloud-Clone Corp. Proteins for HMOX2
  • Cloud-Clone Corp Assay Kits for HMOX2

Sources for HMOX2 Gene

Content
Loading form....