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Aliases for HMOX1 Gene

Aliases for HMOX1 Gene

  • Heme Oxygenase 1 2 3
  • Heme Oxygenase (Decycling) 1 2 3
  • EC 1.14.99.3 4 64
  • HMOX1D 3 6
  • HO-1 3 4
  • Heat Shock Protein, 32-KD 3
  • BK286B10 3
  • HSP32 3
  • HO1 4
  • HO 4

External Ids for HMOX1 Gene

Summaries for HMOX1 Gene

Entrez Gene Summary for HMOX1 Gene

  • Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]

GeneCards Summary for HMOX1 Gene

HMOX1 (Heme Oxygenase 1) is a Protein Coding gene. Diseases associated with HMOX1 include heme oxygenase-1 deficiency and arteriovenous fistula. Among its related pathways are MicroRNAs in cancer and Angiogenesis (CST). GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is HMOX2.

UniProtKB/Swiss-Prot for HMOX1 Gene

  • Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis

Tocris Summary for HMOX1 Gene

  • Heme oxygenase (HO) catalyzes the degradation of heme. This membrane-bound enzyme cleaves the heme ring at the alpha-methene bridge to produce bilverdin (which is metabolized further by bilirubin reductase to form bilirubin), iron and the putative neurotransmitter, carbon monoxide. There are three isoforms of hem oxygenase; the inducible HO-1, which is active at high concentrations of heme and at times of physiological stress, the constitutively active HO-2 and the non-catalytic HO-3, which is thought to function as an oxygen sensor. Hem oxygenase is localized to microsomes and the endoplasmic reticulum, and the enzyme is found at very high concentrations in splenocytes due to their function in the degradation of senescent erythrocytes.

Gene Wiki entry for HMOX1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMOX1 Gene

Genomics for HMOX1 Gene

Genomic Location for HMOX1 Gene

Start:
35,380,361 bp from pter
End:
35,394,214 bp from pter
Size:
13,854 bases
Orientation:
Plus strand

Genomic View for HMOX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMOX1 Gene

Regulatory Elements for HMOX1 Gene

Proteins for HMOX1 Gene

  • Protein details for HMOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09601-HMOX1_HUMAN
    Recommended name:
    Heme oxygenase 1
    Protein Accession:
    P09601
    Secondary Accessions:

    Protein attributes for HMOX1 Gene

    Size:
    288 amino acids
    Molecular mass:
    32819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HMOX1 Gene

neXtProt entry for HMOX1 Gene

Proteomics data for HMOX1 Gene at MOPED

Post-translational modifications for HMOX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMOX1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for HMOX1 Gene

Gene Families for HMOX1 Gene

Protein Domains for HMOX1 Gene

UniProtKB/Swiss-Prot:

HMOX1_HUMAN
Family:
  • Belongs to the heme oxygenase family.:
    • P09601
genes like me logo Genes that share domains with HMOX1: view

Function for HMOX1 Gene

Molecular function for HMOX1 Gene

GENATLAS Biochemistry: heme oxygenase-1,rate limiting enzyme in the degradation of heme to biliverdin,inducible form,ubiquitously expressed following induction by several stresses,potent anti-inflammatory proteins whenever oxidation injury takes place
UniProtKB/Swiss-Prot CatalyticActivity: Protoheme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O
UniProtKB/Swiss-Prot Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis
UniProtKB/Swiss-Prot Induction: Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA

Enzyme Numbers (IUBMB) for HMOX1 Gene

Gene Ontology (GO) - Molecular Function for HMOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004392 heme oxygenase (decyclizing) activity IMP 19556236
GO:0004630 phospholipase D activity IEA --
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 21597468
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with HMOX1: view
genes like me logo Genes that share phenotypes with HMOX1: view

Animal Models for HMOX1 Gene

MGI Knock Outs for HMOX1:

No data available for Transcription Factor Targeting and HOMER Transcription for HMOX1 Gene

Localization for HMOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMOX1 Gene

Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMOX1 Gene COMPARTMENTS Subcellular localization image for HMOX1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
nucleus 3
cytoskeleton 2
cytosol 2
mitochondrion 2
peroxisome 2
plasma membrane 2
vacuole 1

Gene Ontology (GO) - Cellular Components for HMOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 18307065
GO:0005634 nucleus ISS --
GO:0005730 nucleolus IEA --
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with HMOX1: view

Pathways for HMOX1 Gene

genes like me logo Genes that share pathways with HMOX1: view

Pathways by source for HMOX1 Gene

Gene Ontology (GO) - Biological Process for HMOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 12239590
GO:0001666 response to hypoxia --
GO:0001935 endothelial cell proliferation TAS 12239590
GO:0002246 wound healing involved in inflammatory response IMP 9884342
GO:0002686 negative regulation of leukocyte migration TAS 14525760
genes like me logo Genes that share ontologies with HMOX1: view

Compounds for HMOX1 Gene

(1) Tocris Compounds for HMOX1 Gene

Compound Action Cas Number
Tin protoporphyrin IX dichloride Heme oxygenase inhibitor [14325-05-4]

(9) HMDB Compounds for HMOX1 Gene

Compound Synonyms Cas Number PubMed IDs
Bilirubin
  • (4Z,15Z)-Bilirubin IXa
635-65-4
Biliverdin
  • 1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone
114-25-0
Carbon monoxide
  • Carbon monoxide
124-38-9
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
FADH
  • 1,5-dihydro-FAD
1910-41-4

(133) Novoseek inferred chemical compound relationships for HMOX1 Gene

Compound -log(P) Hits PubMed IDs
biliverdin 96.6 131
snpp 89.6 32
cobalt protoporphyrin 89.5 52
zinc protoporphyrin 88.9 77
protoporphyrin ix 82 72
genes like me logo Genes that share compounds with HMOX1: view

Transcripts for HMOX1 Gene

mRNA/cDNA for HMOX1 Gene

Unigene Clusters for HMOX1 Gene

Heme oxygenase (decycling) 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMOX1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for HMOX1 Gene

GeneLoc Exon Structure for
HMOX1
ECgene alternative splicing isoforms for
HMOX1

Expression for HMOX1 Gene

mRNA expression in normal human tissues for HMOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HMOX1 Gene

This gene is overexpressed in Spleen (15.1) and Whole Blood (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMOX1 Gene

SOURCE GeneReport for Unigene cluster for HMOX1 Gene Hs.517581

mRNA Expression by UniProt/SwissProt for HMOX1 Gene

P09601-HMOX1_HUMAN
Tissue specificity: Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
genes like me logo Genes that share expressions with HMOX1: view

Orthologs for HMOX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HMOX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMOX1 36
  • 99.54 (n)
  • 100 (a)
HMOX1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HMOX1 36
  • 85.88 (n)
  • 84.03 (a)
HMOX1 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMOX1 36
  • 87.27 (n)
  • 86.81 (a)
HMOX1 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmox1 36
  • 82.18 (n)
  • 82.29 (a)
Hmox1 16
Hmox1 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 67 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HMOX1 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmox1 36
  • 81.48 (n)
  • 80.21 (a)
chicken
(Gallus gallus)
Aves HMOX1 36
  • 67.83 (n)
  • 65.73 (a)
HMOX1 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HMOX1 37
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68771 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hmox1 36
  • 61.51 (n)
  • 62.59 (a)
zebrafish
(Danio rerio)
Actinopterygii hmox1a 36
  • 56.59 (n)
  • 50 (a)
hmox1a 37
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ho 37
  • 20 (a)
OneToMany
Species with no ortholog for HMOX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMOX1 Gene

ENSEMBL:
Gene Tree for HMOX1 (if available)
TreeFam:
Gene Tree for HMOX1 (if available)

Paralogs for HMOX1 Gene

Paralogs for HMOX1 Gene

Selected SIMAP similar genes for HMOX1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HMOX1: view

Variants for HMOX1 Gene

Sequence variations from dbSNP and Humsavar for HMOX1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs2003038 -- 35,392,916(+) TTTCA(C/T)CATAT intron-variant
rs2071746 -- 35,380,679(+) AGGCT(A/T)TTGCT upstream-variant-2KB
rs2071747 - 35,381,192(+) AACCC(C/G)ACAGG missense, reference
rs2071748 -- 35,381,625(+) TGGCT(A/G)CGGTG intron-variant
rs2071749 -- 35,387,420(+) AGTGA(A/G)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMOX1 Gene

Variant ID Type Subtype PubMed ID
nsv914994 CNV Loss 21882294
nsv914995 CNV Loss 21882294
nsv914996 CNV Loss 21882294
nsv3611 CNV Insertion 18451855
nsv914997 CNV Gain 21882294
nsv914998 CNV Gain 21882294
dgv4958n71 CNV Loss 21882294
nsv915001 CNV Loss 21882294

Relevant External Links for HMOX1 Gene

HapMap Linkage Disequilibrium report
HMOX1
Human Gene Mutation Database (HGMD)
HMOX1

Disorders for HMOX1 Gene

(2) OMIM Diseases for HMOX1 Gene (141250)

UniProtKB/Swiss-Prot

HMOX1_HUMAN
  • Heme oxygenase 1 deficiency (HMOX1D) [MIM:614034]: A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. {ECO:0000269 PubMed:9884342}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(95) Novoseek inferred disease relationships for HMOX1 Gene

Disease -log(P) Hits PubMed IDs
cell damage 60.3 30
inflammation 59.9 129
shock 58.2 105
necrosis 49.9 56
ischemia 47.7 51

Relevant External Links for HMOX1

Genetic Association Database (GAD)
HMOX1
Human Genome Epidemiology (HuGE) Navigator
HMOX1
genes like me logo Genes that share disorders with HMOX1: view

Publications for HMOX1 Gene

  1. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. (PMID: 10631150) Yamada N. … Sasaki H. (Am. J. Hum. Genet. 2000) 3 23 49
  2. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. (PMID: 9884342) Yachie A. … Koizumi S. (J. Clin. Invest. 1999) 3 4 23
  3. Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty. (PMID: 11718398) Exner M. … Wagner O. (J. Endovasc. Ther. 2001) 3 23 49
  4. Heme oxygenase-1 gene promoter polymorphism is associated with abdominal aortic aneurysm. (PMID: 12182912) Schillinger M. … Minar E. (Thromb. Res. 2002) 3 23 49
  5. Neonatal hyperbilirubinemia in Japanese neonates: analysis of the heme oxygenase-1 gene and fetal hemoglobin composition in cord blood. (PMID: 12736395) Kanai M. … Hayasaka K. (Pediatr. Res. 2003) 3 23 49

Products for HMOX1 Gene

Sources for HMOX1 Gene

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