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HMOX1 Gene

protein-coding   GIFtS: 72
GCID: GC22P035776

Heme Oxygenase (Decycling) 1

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heme Oxygenase (Decycling) 11 2     bK286B102
HO-12 3     Heat Shock Protein, 32-KD2
EC 1.14.99.33 8     Heme Oxygenase 12
HMOX1D2 5     HO3
HSP322     HO13

External Ids:    HGNC: 50131   Entrez Gene: 31622   Ensembl: ENSG000001002927   OMIM: 1412505   UniProtKB: P096013   

Export aliases for HMOX1 gene to outside databases

Previous GC identifers: GC22P032473 GC22P034101 GC22P018737


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HMOX1 Gene:
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently
converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase
activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes,
an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase
family. (provided by RefSeq, Jul 2008)

GeneCards Summary for HMOX1 Gene:
HMOX1 (heme oxygenase (decycling) 1) is a protein-coding gene. Diseases associated with HMOX1 include hepatopulmonary syndrome, and vascular cancer. GO annotations related to this gene include enzyme binding and protein homodimerization activity. An important paralog of this gene is HMOX2.

UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601
Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is
subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme
oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits
cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis

summary for HMOX1 Gene:
Heme oxygenase (HO) catalyzes the degradation of heme. This membrane-bound enzyme cleaves the heme ring at
the alpha-methene bridge to produce bilverdin (which is metabolized further by bilirubin reductase to form
bilirubin), iron and the putative neurotransmitter, carbon monoxide. There are three isoforms of hem
oxygenase; the inducible HO-1, which is active at high concentrations of heme and at times of physiological
stress, the constitutively active HO-2 and the non-catalytic HO-3, which is thought to function as an oxygen
sensor. Hem oxygenase is localized to microsomes and the endoplasmic reticulum, and the enzyme is found at
very high concentrations in splenocytes due to their function in the degradation of senescent erythrocytes.

Gene Wiki entry for HMOX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the HMOX1 gene promoter:
         C/EBPbeta   p53   Bach2   p300   AP-4   CREB   deltaCREB   HSF2   ARP-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HMOX1 promoter sequence
   Search Chromatin IP Primers for HMOX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMOX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12

HMOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMOX1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P035776:  view genomic region     (about GC identifiers)

Start:
35,776,354 bp from pter      End:
35,790,207 bp from pter
Size:
13,854 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601 (See protein sequence)
Recommended Name: Heme oxygenase 1  
Size: 288 amino acids; 32819 Da
Selected PDB 3D structures from and Proteopedia for HMOX1 (see all 23):
1N3U (3D)        1N45 (3D)        1NI6 (3D)        1OYK (3D)        1OYL (3D)        1OZE (3D)    

Explore the universe of human proteins at neXtProt for HMOX1: NX_P09601

Explore proteomics data for HMOX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HMOX1 (P09601) (see all 7)
     YFPEELHR  GEGLAFFTF  GDLSGGQVLKK  PELLVAHAYTRY 


    See HMOX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002124.1  
    ENSEMBL proteins: 
     ENSP00000413316   ENSP00000216117  
    Reactome Protein details: P09601

    HMOX1 Human Recombinant Protein Products:

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    Novus Biologicals HMOX1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HMOX1
    Browse Proteins at Cloud-Clone Corp.

    HMOX1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HMOX1
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    HMOX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Enzo Life Sciences assays for HMOX1
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Haem oxygenase 1
    Haem oxygenase

    4 InterPro protein domains:
     IPR016053 Haem_Oase-like
     IPR018207 Haem_oxygenase_CS
     IPR016084 Haem_Oase-like_multi-hlx
     IPR002051 Haem_Oase

    Graphical View of Domain Structure for InterPro Entry P09601

    ProtoNet protein and cluster: P09601

    1 Blocks protein domain: IPB002051 Heme oxygenase

    UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601
    Similarity: Belongs to the heme oxygenase family


    HMOX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMOX1_HUMAN, P09601
    Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is
    subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme
    oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits
    cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis
    Catalytic activity: Protoheme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O
    Induction: Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances
    such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA

         Genatlas biochemistry entry for HMOX1:
    heme oxygenase-1,rate limiting enzyme in the degradation of heme to biliverdin,inducible form,ubiquitously
    expressed following induction by several stresses,potent anti-inflammatory proteins whenever oxidation injury
    takes place

         Enzyme Number (IUBMB): EC 1.14.99.31 2

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004392heme oxygenase (decyclizing) activity IMP19556236
    GO:0004630phospholipase D activity IEA--
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding ----
    GO:0016491oxidoreductase activity ----
         
    HMOX1 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hmox1):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     muscle  renal/urinary system  reproductive system  respiratory system 

    HMOX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HMOX1: Hmox1tm1Poss Hmox1tm1Ysh Hmox1tm1Mlee Hmox1tm1.2Gkl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HMOX1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HMOX1

    miRNA
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    miRTarBase miRNAs that target HMOX1:
    hsa-mir-196a-5p (MIRT004719), hsa-mir-128-3p (MIRT021967), hsa-mir-148b-3p (MIRT019368), hsa-mir-16-5p (MIRT001455), hsa-mir-335-5p (MIRT017714), hsa-mir-122-5p (MIRT023272), hsa-mir-26b-5p (MIRT029307), hsa-mir-1 (MIRT023697), hsa-mir-124-3p (MIRT022531)

    Block miRNA regulation of human, mouse, rat HMOX1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate HMOX1:
    hsa-miR-873 hsa-miR-525-5p hsa-miR-1205 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidHMOX1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HMOX1

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    OriGene clones in human, mouse for HMOX1 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: HMOX1 (NM_002133)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMOX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMOX1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for HMOX1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMOX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HMOX1_HUMAN, P09601: Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular4
    nucleus3
    cytoskeleton2
    cytosol2
    mitochondrion2
    peroxisome2
    plasma membrane2
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS18307065
    GO:0005634nucleus ISS--
    GO:0005730nucleolus IEA--
    GO:0005783endoplasmic reticulum ISS--
    GO:0005789endoplasmic reticulum membrane TAS--

    HMOX1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HMOX1 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of porphyrins
    Metabolism of porphyrins0.56
    Heme degradation0.00
    Porphyrin and chlorophyll metabolism0.56
    heme degradation0.00
    2Insulin receptor recycling
    Iron uptake and transport0.70
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    4NOD-like Receptor Signaling Pathways
    Immune response IL 1 signaling pathway0.42
    5Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HMOX1
        IL-10 Pathway

    2 Cell Signaling Technology (CST) Pathways for HMOX1
        Angiogenesis
    Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for HMOX1
        Immune response IL-1 signaling pathway

    5 BioSystems Pathways for HMOX1
        Keap1-Nrf2 Pathway
    Oxidative Stress
    heme degradation
    HIF-1-alpha transcription factor network
    Validated transcriptional targets of AP1 family members Fra1 and Fra2

    2 Reactome Pathways for HMOX1
        Heme degradation
    Iron uptake and transport


    4 Kegg Pathways  (Kegg details for HMOX1):
        Porphyrin and chlorophyll metabolism
    HIF-1 signaling pathway
    Mineral absorption
    MicroRNAs in cancer


    HMOX1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HMOX1 (see all 13): 
              Nephrotoxicity in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Oxidative Stress in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HMOX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HMOX1 (P096013 ENSP000002161174) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOS1P294753, ENSP000003207584I2D: score=1 STRING: ENSP00000320758
    PRKCEQ021563, ENSP000003061244I2D: score=1 STRING: ENSP00000306124
    UFD1LQ928903, ENSP000002632024I2D: score=1 STRING: ENSP00000263202
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    AKT1P317493, ENSP000002702024I2D: score=2 STRING: ENSP00000270202
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS12239590
    GO:0001666response to hypoxia ----
    GO:0001935endothelial cell proliferation TAS12239590
    GO:0002246wound healing involved in inflammatory response IMP9884342
    GO:0002686negative regulation of leukocyte migration TAS14525760

    HMOX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HMOX1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Tin protoporphyrin IX dichlorideHeme oxygenase inhibitor[14325-05-4]

    9 HMDB Compounds for HMOX1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Bilirubin(4Z,15Z)-Bilirubin IXa (see all 17)635-65-418206168
    Biliverdin1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone (see all 7)114-25-0--
    Carbon monoxideCarbon monoxide (see all 2)124-38-9--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    FADH1,5-dihydro-FAD (see all 19)1910-41-4--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10 DrugBank Compounds for HMOX1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--12897089 17139284 12699699 17016423
    Biliverdine Ix Alpha-- 114-25-0target--17139284 17016423 10592235
    Formic AcidAminic acid (see all 5)64-18-6target--17139284 17016423 10592235
    Heme-- --target--17139284 17016423 10592235
    12-Phenylheme-- --target--17139284 17016423
    2-Phenylheme-- --target--17139284 17016423
    1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone-- --target--10592235
    1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE-- --target--10592235
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9enzymeinducer20153624
    Verdoheme-- --target----

    Selected Novoseek inferred chemical compound relationships for HMOX1 gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    biliverdin 96.6 388 15741166 (5), 18385824 (4), 17825497 (3), 15004156 (3) (see all 99)
    snpp 89.6 51 10655786 (2), 17215323 (2), 19797297 (2), 9596945 (2) (see all 25)
    cobalt protoporphyrin 89.5 77 20131233 (2), 16309584 (2), 17919492 (2), 12352873 (2) (see all 43)
    zinc protoporphyrin 88.9 145 11222374 (7), 20021945 (3), 18665050 (3), 16804400 (2) (see all 63)
    protoporphyrin ix 82 104 12591764 (2), 11238670 (2), 7545388 (1), 10655786 (1) (see all 70)
    verdoheme 81.5 16 9063888 (2), 9054378 (2), 18331037 (2), 16154530 (1) (see all 8)
    copp 80.2 83 17065227 (6), 17964723 (5), 19387321 (3), 15932518 (3) (see all 28)
    iron 78.4 563 18774956 (8), 16439612 (6), 19777608 (6), 10872745 (5) (see all 99)
    mesoporphyrin 76.2 13 12835114 (1), 11435909 (1), 10933875 (1), 15564944 (1) (see all 11)
    sn mesoporphyrin 76 12 11053673 (1), 14614191 (1), 12933701 (1), 14600247 (1) (see all 7)



    HMOX1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HMOX1 gene: 
    NM_002133.2  

    Unigene Cluster for HMOX1:

    Heme oxygenase (decycling) 1
    Hs.517581  [show with all ESTs]
    Unigene Representative Sequence: BG165629
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412893 ENST00000216117(uc003ant.2) ENST00000481190 ENST00000494998

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat HMOX1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate HMOX1:
    hsa-miR-873 hsa-miR-525-5p hsa-miR-1205 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidHMOX1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HMOX1
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    GenScript: all cDNA clones in your preferred vector: HMOX1 (NM_002133)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMOX1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat HMOX1
      QuantiFast Probe-based Assays in human, mouse, rat HMOX1

    Additional mRNA sequence: 

    AF051791.1 AK313120.1 BC001491.2 BT019785.1 CR456505.1 CR541945.1 CR541968.1 GU187012.1 
    JF323038.1 M23041.1 M23042.1 X06985.1 

    12 DOTS entries:

    DT.316089  DT.100826177  DT.100826183  DT.120670488  DT.100763288  DT.100772294  DT.91691570  DT.100036770 
    DT.100696678  DT.100736928  DT.120670441  DT.91842270 

    Selected AceView cDNA sequences (see all 341):

    CR623301 AI351079 CR541945 CR456505 H77724 BX368461 BQ708471 CA306357 
    CB146156 CR590034 BI835173 CR611539 CR623238 AI754564 BU660248 CR615893 
    CR625550 BQ710923 BQ711440 AI468142 CR541968 BM981740 CR622130 BP341746 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HMOX1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                          -                             -         
    SP2:                          -                                       
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for HMOX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HMOX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTGGGTGGG
    HMOX1 Expression
    About this image


    HMOX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
             HyStem+BMP4-induced E15 cells
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast-like cells
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    HMOX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMOX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517581

    UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601
    Tissue specificity: Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HMOX1 (see all 13): 
              Nephrotoxicity in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Oxidative Stress in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for HMOX1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmox11 , 5 heme oxygenase (decycling) 11, 5 82.18(n)1
    82.29(a)1
      8 (35.59 cM)5
    153681  NM_010442.21  NP_034572.11 
     750935915 
    chicken
    (Gallus gallus)
    Aves HMOX11 heme oxygenase (decycling) 1 67.83(n)
    65.73(a)
      396287  NM_205344.1  NP_990675.1 
    lizard
    (Anolis carolinensis)
    Reptilia HMOX16
    heme oxygenase (decycling) 1
    50(a)
    1 ↔ 1
    5(21483006-21495964)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687712 hypothetical protein MGC68771 74.32(n)    BC060435.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmox1a1 heme oxygenase (decycling) 1a 56.59(n)
    50(a)
      791518  NM_001127516.1  NP_001120988.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ho6
    Heme oxygenase
    20(a)
    1 → many
    3R(7505481-7506698)


    ENSEMBL Gene Tree for HMOX1 (if available)
    TreeFam Gene Tree for HMOX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HMOX1 gene
    HMOX22  
    2 SIMAP similar genes for HMOX1 using alignment to 6 protein entries:     HMOX1_HUMAN (see all proteins):
    HO1    HMOX2

    HMOX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HMOX1 (see all 505)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453958461,2
    --18735624(+) GGTGTG/TAGCCA 1 -- us2k10--------
    rs96195341,2
    C,F--18735631(+) gccacC/Tgcgcc 1 -- us2k13Minor allele frequency- T:0.01NA NS 94
    rs1426490481,2
    --18735632(+) CCACCA/GCGCCC 1 -- us2k10--------
    rs1447950851,2
    --18735767(+) AGTGCC/TAAGAG 1 -- us2k10--------
    rs1458213301,2
    --18735914(+) TCTGCA/GTTCCC 1 -- us2k10--------
    rs1171293571,2
    F--18736054(+) TTTGTC/TGGTTG 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs96195361,2
    C,F,A--18736066(+) ttttcG/Agggaa 1 -- us2k19Minor allele frequency- A:0.21NS WA CSA NA EA 453
    rs96195371,2
    C--18736161(+) TGCCTC/TTGGGC 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs57557121,2
    C,A--18736205(+) TTTTTG/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.50NA 2
    rs2003298631,2
    C--18736207(+) TTTTTG/TTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HMOX1 (35776354 - 35790207 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for HMOX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3611CNV Insertion18451855
    dgv4958n71CNV Loss21882294
    nsv914995CNV Loss21882294
    nsv914996CNV Loss21882294
    nsv914994CNV Loss21882294
    nsv915001CNV Loss21882294
    nsv914997CNV Gain21882294
    nsv914998CNV Gain21882294

    Human Gene Mutation Database (HGMD): HMOX1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HMOX1
    DNA2.0 Custom Variant and Variant Library Synthesis for HMOX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 141250   
    OMIM disorders: 614034  606963  
    UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601
  • Heme oxygenase 1 deficiency (HMOX1D) [MIM:614034]: A disease characterized by impaired stress
    hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation
    abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include
    persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and
    hepatomegaly. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for HMOX1 (see all 198):    
    About MalaCards
    hepatopulmonary syndrome    vascular cancer    heme oxygenase-1 deficiency    congenital hydronephrosis
    arteriovenous fistula    pulmonary disease, chronic obstructive    pulmonary arteriovenous malformation    superficial siderosis
    central retinal artery occlusion    hepatoerythropoietic porphyria    primary spontaneous pneumothorax    acute hepatic porphyria
    arthus reaction    renovascular hypertension    siderosis    arteriovenous malformation
    corticobasal degeneration    retinal artery occlusion    peyronie's disease    peyronies disease

    8 diseases from the University of Copenhagen DISEASES database for HMOX1:
    Vascular disease     Brain disease     Lung disease     Kidney disease
    Toxic encephalopathy     Cancer     Heart disease     Diabetes mellitus

    HMOX1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for HMOX1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cell damage 60.3 40 15378604 (4), 11707736 (2), 16971418 (2), 19245827 (2) (see all 24)
    inflammation 59.9 186 11135063 (4), 19076005 (4), 17384141 (3), 16234431 (3) (see all 99)
    shock 58.2 154 15618017 (3), 8645700 (3), 8652820 (2), 18024796 (2) (see all 95)
    necrosis 49.9 82 18262556 (2), 20193368 (2), 9530200 (2), 12894236 (1) (see all 53)
    ischemia 47.7 63 17522519 (3), 16775600 (2), 15996234 (2), 20222175 (2) (see all 40)
    neurodegenerative diseases 46 21 12835114 (2), 18289070 (2), 9003061 (1), 19457088 (1) (see all 16)
    atherosclerosis 42.9 46 16999951 (3), 18769232 (2), 18289069 (2), 13678532 (1) (see all 29)
    hemolysis intravascular 39.7 2 19380867 (1), 20001631 (1)
    cerebral vasospasm 37.3 13 19686725 (4), 11808338 (2), 14657544 (1), 15571165 (1) (see all 5)
    porphyria acute intermittent 35.8 1 17973866 (1)

    Genetic Association Database (GAD): HMOX1
    Human Genome Epidemiology (HuGE) Navigator: HMOX1 (126 documents)

    Export disorders for HMOX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HMOX1 gene, integrated from 10 sources (see all 1901):
    (articles sorted by number of sources associating them with HMOX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    2. Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome. (PubMed id 19526221)1, 4, 9 Sheu C.C....Christiani D.C. (Intensive Care Med 2009)
    3. Heme oxygenase-1 genotype and restenosis after balloon angioplasty: a novel vascular protective factor. (PubMed id 15028349)1, 4, 9 Schillinger M....Wagner O. (J. Am. Coll. Cardiol. 2004)
    4. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus. (PubMed id 17991645)1, 4, 9 Arredondo M....Hertrampf E. (Am. J. Clin. Nutr. 2007)
    5. Association of susceptibility to the development of pneumonia in the older Japanese population with haem oxygenase-1 gene promoter polymorphism. (PubMed id 16582079)1, 4, 9 Yasuda H....Sasaki H. (J. Med. Genet. 2006)
    6. Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population. (PubMed id 19886851)1, 4, 9 Yun L....Gu D. (Clin. Exp. Hypertens. 2009)
    7. Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk. (PubMed id 19255063)1, 4, 9 Li Y....Hong C.C. (Carcinogenesis 2009)
    8. No genetic association between polymorphisms of heme oxygenase 1 and 2 and Alzheimer's disease in a Japanese population. (PubMed id 19246912)1, 4, 9 Shibata N....Arai H. (Dement Geriatr Cogn Disord 2009)
    9. Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters. (PubMed id 18502573)1, 4, 9 Sawa T....Ohshima H. (Cancer Lett. 2008)
    10. Synergistic effect of heme oxygenase-1 and tau genetic variants on Alzheimer's disease risk. (PubMed id 18841019)1, 4, 9 Mateo I....Combarros O. (Dement Geriatr Cogn Disord 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3162 HGNC: 5013 AceView: HMOX1 Ensembl:ENSG00000100292 euGenes: HUgn3162
    ECgene: HMOX1 Kegg: 3162 H-InvDB: HMOX1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HMOX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HMOX1 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/hmox1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HMOX1 gene:
    Search GeneIP for patents involving HMOX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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