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Aliases for HMOX1 Gene

Aliases for HMOX1 Gene

  • Heme Oxygenase 1 2 3
  • Heme Oxygenase (Decycling) 1 2 3
  • EC 1.14.99.3 4 63
  • HO-1 3 4
  • Heat Shock Protein, 32-KD 3
  • BK286B10 3
  • HMOX1D 3
  • HSP32 3
  • HO1 4
  • HO 4

External Ids for HMOX1 Gene

Previous GeneCards Identifiers for HMOX1 Gene

  • GC22P032473
  • GC22P034101
  • GC22P035776
  • GC22P018737

Summaries for HMOX1 Gene

Entrez Gene Summary for HMOX1 Gene

  • Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]

GeneCards Summary for HMOX1 Gene

HMOX1 (Heme Oxygenase 1) is a Protein Coding gene. Diseases associated with HMOX1 include heme oxygenase-1 deficiency and pulmonary disease, chronic obstructive. Among its related pathways are MicroRNAs in cancer and Angiogenesis (CST). GO annotations related to this gene include protein homodimerization activity and oxidoreductase activity. An important paralog of this gene is HMOX2.

UniProtKB/Swiss-Prot for HMOX1 Gene

  • Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis

Tocris Summary for HMOX1 Gene

  • Heme oxygenase (HO) catalyzes the degradation of heme. It is a membrane-bound enzyme that cleaves the heme ring at the alpha-methene bridge to produce bilverdin (which is metabolized further by bilirubin reductase to form bilirubin), iron and carbon monoxide.

Gene Wiki entry for HMOX1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMOX1 Gene

Genomics for HMOX1 Gene

Regulatory Elements for HMOX1 Gene

Genomic Location for HMOX1 Gene

Chromosome:
22
Start:
35,380,361 bp from pter
End:
35,394,214 bp from pter
Size:
13,854 bases
Orientation:
Plus strand

Genomic View for HMOX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMOX1 Gene

Proteins for HMOX1 Gene

  • Protein details for HMOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09601-HMOX1_HUMAN
    Recommended name:
    Heme oxygenase 1
    Protein Accession:
    P09601

    Protein attributes for HMOX1 Gene

    Size:
    288 amino acids
    Molecular mass:
    32819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HMOX1 Gene

neXtProt entry for HMOX1 Gene

Proteomics data for HMOX1 Gene at MOPED

Post-translational modifications for HMOX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMOX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HMOX1 (HO-1/HMOX1/HSP32)
  • Cell Signaling Technology (CST) Antibodies for HMOX1 (HMOX1)

Domains & Families for HMOX1 Gene

Gene Families for HMOX1 Gene

Protein Domains for HMOX1 Gene

Graphical View of Domain Structure for InterPro Entry

P09601

UniProtKB/Swiss-Prot:

HMOX1_HUMAN :
  • Belongs to the heme oxygenase family.
Family:
  • Belongs to the heme oxygenase family.
genes like me logo Genes that share domains with HMOX1: view

Function for HMOX1 Gene

Molecular function for HMOX1 Gene

GENATLAS Biochemistry:
heme oxygenase-1,rate limiting enzyme in the degradation of heme to biliverdin,inducible form,ubiquitously expressed following induction by several stresses,potent anti-inflammatory proteins whenever oxidation injury takes place
UniProtKB/Swiss-Prot CatalyticActivity:
Protoheme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O
UniProtKB/Swiss-Prot Function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis
UniProtKB/Swiss-Prot Induction:
Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA

Enzyme Numbers (IUBMB) for HMOX1 Gene

Gene Ontology (GO) - Molecular Function for HMOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004392 heme oxygenase (decyclizing) activity IMP 19556236
GO:0004630 phospholipase D activity IEA --
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 21597468
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with HMOX1: view
genes like me logo Genes that share phenotypes with HMOX1: view

Animal Models for HMOX1 Gene

MGI Knock Outs for HMOX1:

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for HMOX1 Gene

Localization for HMOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMOX1 Gene

Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMOX1 Gene COMPARTMENTS Subcellular localization image for HMOX1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
cytosol 3
mitochondrion 3
nucleus 3
cytoskeleton 2
golgi apparatus 2
plasma membrane 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HMOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 18307065
GO:0005634 nucleus ISS --
GO:0005730 nucleolus IEA --
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with HMOX1: view

Pathways & Interactions for HMOX1 Gene

genes like me logo Genes that share pathways with HMOX1: view

PCR Array Products

SIGNOR curated interactions for HMOX1 Gene

Other effect:

Gene Ontology (GO) - Biological Process for HMOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 12239590
GO:0001666 response to hypoxia --
GO:0001935 endothelial cell proliferation TAS 12239590
GO:0002246 wound healing involved in inflammatory response IMP 9884342
GO:0002686 negative regulation of leukocyte migration TAS 14525760
genes like me logo Genes that share ontologies with HMOX1: view

Drugs & Compounds for HMOX1 Gene

(72) Drugs for HMOX1 Gene - From: NovoSeek, DrugBank, HMDB, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved Nutra Enzyme, inducer 350,355
FAD Approved Pharma 0
Allopurinol Approved Pharma 125
Aminolevulinic acid Approved Pharma 128
Aspirin Approved Pharma Channel blocker 971

(78) Additional Compounds for HMOX1 Gene - From: NovoSeek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
FADH
  • 1,5-Dihydro-FAD
  • 1,5-Dihydro-P-5-ester with adenosine
  • 1,5-Dihydro-Riboflavin 5'-(trihydrogen diphosphate) P'->5'-ester with adenosine
  • Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with 5,10-dihydro-7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)alloxazine
  • Adenosine 5'-(trihydrogen pyrophosphate), 5'->5'-ester with 5,10-dihydro-7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)alloxazine
1910-41-4
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Fe3+
  • Fe(III)
  • Ferric ion
  • Iron(3+)
7439-89-6
genes like me logo Genes that share compounds with HMOX1: view

Transcripts for HMOX1 Gene

mRNA/cDNA for HMOX1 Gene

Unigene Clusters for HMOX1 Gene

Heme oxygenase (decycling) 1:
Representative Sequences:

miRNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMOX1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for HMOX1 Gene

GeneLoc Exon Structure for
HMOX1
ECgene alternative splicing isoforms for
HMOX1

Expression for HMOX1 Gene

mRNA expression in normal human tissues for HMOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HMOX1 Gene

This gene is overexpressed in Spleen (x15.1) and Whole Blood (x6.3).

Protein differential expression in normal tissues from HIPED for HMOX1 Gene

This gene is overexpressed in Bone (29.3) and Spleen (21.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMOX1 Gene



SOURCE GeneReport for Unigene cluster for HMOX1 Gene Hs.517581

mRNA Expression by UniProt/SwissProt for HMOX1 Gene

P09601-HMOX1_HUMAN
Tissue specificity: Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
genes like me logo Genes that share expression patterns with HMOX1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for HMOX1 Gene

Orthologs for HMOX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HMOX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HMOX1 35
  • 85.88 (n)
  • 84.03 (a)
HMOX1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMOX1 35
  • 87.27 (n)
  • 86.81 (a)
HMOX1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmox1 35
  • 82.18 (n)
  • 82.29 (a)
Hmox1 16
Hmox1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HMOX1 35
  • 99.54 (n)
  • 100 (a)
HMOX1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmox1 35
  • 81.48 (n)
  • 80.21 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HMOX1 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves HMOX1 35
  • 67.83 (n)
  • 65.73 (a)
HMOX1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HMOX1 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hmox1 35
  • 61.51 (n)
  • 62.59 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68771 35
zebrafish
(Danio rerio)
Actinopterygii hmox1a 35
  • 56.59 (n)
  • 50 (a)
hmox1a 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ho 36
  • 20 (a)
OneToMany
Species with no ortholog for HMOX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMOX1 Gene

ENSEMBL:
Gene Tree for HMOX1 (if available)
TreeFam:
Gene Tree for HMOX1 (if available)

Paralogs for HMOX1 Gene

Paralogs for HMOX1 Gene

(2) SIMAP similar genes for HMOX1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HMOX1: view

Variants for HMOX1 Gene

Sequence variations from dbSNP and Humsavar for HMOX1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs200939820 -- 35,393,471(+) AGATT(C/G)TGCCC reference, missense
rs200966095 -- 35,386,998(+) CCAGA(A/T)AGCCC reference, missense
rs369027713 -- 35,382,737(+) GATCT(C/T)AGCTC intron-variant
rs369019087 -- 35,386,773(+) TGTCT(A/G)CTTCC reference, missense
rs368962256 -- 35,388,953(+) CAAAT(C/T)TAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMOX1 Gene

Variant ID Type Subtype PubMed ID
nsv914994 CNV Loss 21882294
nsv914995 CNV Loss 21882294
nsv914996 CNV Loss 21882294
nsv3611 CNV Insertion 18451855
nsv914997 CNV Gain 21882294
nsv914998 CNV Gain 21882294
dgv4958n71 CNV Loss 21882294
nsv915001 CNV Loss 21882294

Variation tolerance for HMOX1 Gene

Residual Variation Intolerance Score: 81.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HMOX1 Gene

HapMap Linkage Disequilibrium report
HMOX1
Human Gene Mutation Database (HGMD)
HMOX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMOX1 Gene

Disorders for HMOX1 Gene

MalaCards: The human disease database

(36) MalaCards diseases for HMOX1 Gene - From: OMIM, ClinVar, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
heme oxygenase-1 deficiency
  • heme oxygenase 1 deficiency
pulmonary disease, chronic obstructive
  • copd, rate of decline of lung function in
hemorrhagic cystitis
central retinal artery occlusion
  • retinal artery occlusion
toxic encephalopathy
  • neurotoxicity
- elite association
Search HMOX1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HMOX1_HUMAN
  • Heme oxygenase 1 deficiency (HMOX1D) [MIM:614034]: A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. {ECO:0000269 PubMed:9884342}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HMOX1

Genetic Association Database (GAD)
HMOX1
Human Genome Epidemiology (HuGE) Navigator
HMOX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HMOX1
genes like me logo Genes that share disorders with HMOX1: view

No data available for Genatlas for HMOX1 Gene

Publications for HMOX1 Gene

  1. Oxidative stress-related factors in Bartter's and Gitelman's syndromes: relevance for angiotensin II signalling. (PMID: 12897089) CalA^ L.A. … Semplicini A. (Nephrol. Dial. Transplant. 2003) 23 25 67
  2. Inhibition of heme oxygenase-1 with an epidermal growth factor receptor inhibitor and cisplatin decreases proliferation of lung cancer A549 cells. (PMID: 19375813) Kuroda H. … Ishigatsubo Y. (Lung Cancer 2010) 23 67
  3. Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture. (PMID: 19558496) Wagner A.E. … Rimbach G. (Exp. Dermatol. 2010) 23 67
  4. Pivotal Advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity. (PMID: 19797297) Biburger M. … Tiegs G. (J. Leukoc. Biol. 2010) 23 67
  5. Chlorobenzene induces oxidative stress in human lung epithelial cells in vitro. (PMID: 19800902) Feltens R. … Lehmann I. (Toxicol. Appl. Pharmacol. 2010) 23 67

Products for HMOX1 Gene

Sources for HMOX1 Gene

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