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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HMOX1 Gene

protein-coding GIFtS: 73
GCID: GC22P035776

heme oxygenase (decycling) 1

Explore 196 diseases affiliated with
HMOX1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heme Oxygenase (Decycling) 1¹ ²		HSP32²
HO-1¹ ² ³		Heat Shock Protein, 32-KD²
BK286B10¹		Heme Oxygenase 1²
EC 1.14.99.3³ ⁸		HO³
HMOX1D²		HO1³

External Ids:	HGNC: 5013¹	Entrez Gene: 3162²	Ensembl: ENSG00000100292⁷	OMIM: 141250⁵	UniProtKB: P09601³

Export aliases for HMOX1 gene to outside databases

Previous GC identifers: GC22P032473 GC22P034101 GC22P018737

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HMOX1:

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently

converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase

activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an

inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601

Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is

subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme

oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed

summary for HMOX1:

Heme oxygenase (HO) catalyzes the degradation of heme. This membrane-bound enzyme cleaves the heme ring at

the alpha-methene bridge to produce bilverdin (which is metabolized further by bilirubin reductase to form

bilirubin), iron and the putative neurotransmitter, carbon monoxide. There are three isoforms of hem

oxygenase; the inducible HO-1, which is active at high concentrations of heme and at times of physiological

stress, the constitutively active HO-2 and the non-catalytic HO-3, which is thought to function as an oxygen

sensor. Hem oxygenase is localized to microsomes and the endoplasmic reticulum, and the enzyme is found at

very high concentrations in splenocytes due to their function in the degradation of senescent erythrocytes.

Gene Wiki entry for HMOX1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HMOX1 gene promoter:
C/EBPbeta p53 Bach2 p300 AP-4 CREB deltaCREB HSF2 ARP-1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HMOX1 promoter sequence

Search SABiosciences Chromatin IP Primers for HMOX1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMOX1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q12

HMOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMOX1 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P035776: view genomic region (about GC identifiers)

Start:	35,776,354 bp from pter	End:	35,790,207 bp from pter
Size:	13,854 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601 (See protein sequence)

Recommended Name: Heme oxygenase 1

Size: 288 amino acids; 32819 Da

Subcellular location: Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side

6/23 PDB 3D structures from and Proteopedia for HMOX1 (see all 23):

1N3U (3D)

1N45 (3D)

1NI6 (3D)

1OYK (3D)

1OYL (3D)

1OZE (3D)

Explore the universe of human proteins at neXtProt for HMOX1: NX_P09601

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09601

4/7 DME Specific Peptides for HMOX1 (P09601) (see all 7)

YFPEELHR

GEGLAFFTF

GDLSGGQVLKK

PELLVAHAYTRY

HMOX1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002124.1

ENSEMBL proteins:

ENSP00000413316 ENSP00000216117

Reactome Protein details: P09601
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant HMOX1 Protein
	R&D Systems Recombinant & Natural Proteins for HMOX1 (HO-1/HMOX1/HSP32)
	Enzo Life Sciences proteins for HMOX1
	OriGene Purified Protein: HMOX1 OriGene Protein Over-expression Lysate: HMOX1 OriGene Custom Protein Services for HMOX1
	GenScript Custom Purified and Recombinant Proteins Services for HMOX1
	Novus Biologicals HMOX1 Proteins Novus Biologicals HMOX1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for HMOX1
	Uscn Proteins for HMOX1

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	18307065
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	ISS	--
GO:0005730	nucleolus	IEA	--
GO:0005783	endoplasmic reticulum	ISS	--

HMOX1 for ontologies About GeneDecksing

HMOX1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HMOX1
	R&D Systems Antibodies for HMOX1 (HO-1/HMOX1/HSP32)
	Cell Signaling Technology (CST) Antibodies for HMOX1
	OriGene Antibodies (see all 4): HMOX1 OriGene Custom Antibody Services for HMOX1
	GenScript Custom Superior Antibodies Services for HMOX1
	Novus Biologicals HMOX1 Antibodies
	Abcam antibodies for HMOX1
	Uscn Antibodies for HMOX1
	ThermoFisher Antibodies for HMOX1

Assay Products for HMOX1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for HMOX1 (HO-1/HMOX1/HSP32) (see all)
	GenScript Custom Assay Services for HMOX1
	Enzo Life Sciences assays for HMOX1
	Uscn ELISAs and CLIAs for HMOX1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HMOX1 for domains About GeneDecksing

4 InterPro domains/families:

IPR016053 Haem_Oase-like

IPR018207 Haem_oxygenase_CS

IPR016084 Haem_Oase-like_multi-hlx

IPR002051 Haem_Oase

Graphical View of Domain Structure for InterPro Entry P09601

ProtoNet protein and cluster: P09601

1 Blocks protein family: IPB002051 Heme oxygenase

UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601

Similarity: Belongs to the heme oxygenase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601

Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is

subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme

oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed

Catalytic activity: Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O

Induction: Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such

as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA

Genatlas biochemistry entry for HMOX1:

heme oxygenase-1,rate limiting enzyme in the degradation of heme to biliverdin,inducible form,ubiquitously expressed

following induction by several stresses,potent anti-inflammatory proteins whenever oxidation injury takes place

Enzyme Number (IUBMB): EC 1.14.99.3¹ ²

miRNA Products:		miRTarBase miRNAs that target HMOX1: hsa-mir-196a (MIRT004719), hsa-mir-16 (MIRT001455)

		OriGene 3'-UTR Clone: HMOX1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HMOX1
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate HMOX1:
		hsa-miR-873 hsa-miR-525-5p hsa-miR-1205 hsa-miR-520a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: HMOX1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMOX1 (see all 7) OriGene shRNA RFP: HMOX1 OriGene siRNA: HMOX1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMOX1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HMOX1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMOX1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMOX1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HMOX1 (NM_002133)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMOX1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMOX1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HMOX1
		Search LifeMap BioReagents cell lines for HMOX1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMOX1

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004392	heme oxygenase (decyclizing) activity	IMP	19556236
GO:0004630	phospholipase D activity	IEA	--
GO:0004871	signal transducer activity	IMP	12761501
GO:0005515	protein binding	--	--
GO:0016491	oxidoreductase activity	--	--

HMOX1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for HMOX1: Hmox1^tm1Poss Hmox1^tm1Ysh Hmox1^tm1Mlee Hmox1^tm1.2Gkl
     14 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Hmox1):

behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	liver/biliary system	mortality/aging
muscle	renal/urinary system	reproductive system	respiratory system

HMOX1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_IL-1 signaling pathway

Immune response_IL-1 signaling pathway

1.00

Immune response IL-1 signaling pathway

0.98

heme degradation

heme degradation

1.00

Heme degradation

0.80

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Angiogenesis

Angiogenesis

1.00

Metabolism

Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for HMOX1

Immune response IL-1 signaling pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HMOX1

IL-10 Pathway

2 Cell Signaling Technology (CST) Pathways for HMOX1

	Angiogenesis
	Lymphocyte Signaling

1 GeneGo (Thomson Reuters) Pathway for HMOX1

Immune response IL-1 signaling pathway

5 BioSystems Pathways for HMOX1

	Keap1-Nrf2 Pathway
	heme degradation
	Oxidative Stress
	HIF-1-alpha transcription factor network
	Validated transcriptional targets of AP1 family members Fra1 and Fra2

5 Reactome Pathways for HMOX1

	Metabolism of porphyrins
	Transmembrane transport of small molecules
	Metabolism
	Heme degradation
	Iron uptake and transport

2 Kegg Pathways (Kegg details for HMOX1):

	Porphyrin and chlorophyll metabolism
	Mineral absorption

HMOX1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HMOX1

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/21 Interacting proteins for HMOX1 (P09601³ ENSP00000216117⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NOS1	P29475³, ENSP00000320758⁴	I2D: score=1 STRING: ENSP00000320758
UFD1L	Q92890³, ENSP00000263202⁴	I2D: score=1 STRING: ENSP00000263202
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
AKT1	P31749³, ENSP00000270202⁴	I2D: score=2 STRING: ENSP00000270202
BLVRB	P30043³, ENSP00000263368⁴	I2D: score=2 STRING: ENSP00000263368

About this table

Gene Ontology (GO): 5/51 biological process terms (GO ID links to tree view) (see all 51): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	TAS	12239590
GO:0001666	response to hypoxia	--	--
GO:0001935	endothelial cell proliferation	TAS	12239590
GO:0002246	wound healing involved in inflammatory response	IMP	9884342
GO:0002686	negative regulation of leukocyte migration	TAS	14525760

HMOX1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HMOX1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for HMOX1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Zinc protoporphyrin IX	Heme oxygenase and guanylyl cyclase inhibitor	[15442-64-5]
Tin protoporphyrin IX dichloride	Heme oxygenase inhibitor	[14325-05-4]

9 HMDB Compounds for HMOX1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Bilirubin	(4Z,15Z)-Bilirubin IXa (see all 17)	635-65-4	18206168
Biliverdin	1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone (see all 7)	114-25-0	--
Carbon monoxide	Carbon monoxide (see all 2)	124-38-9	--
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
FADH	1,5-dihydro-FAD (see all 19)	1910-41-4	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

10 DrugBank Compounds for HMOX1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
NADH	beta-DPNH (see all 18)	606-68-8	target	--	12897089 17139284 12699699 17016423
Biliverdine Ix Alpha	--	114-25-0	target	--	17139284 17016423 10592235
Formic Acid	Aminic acid (see all 5)	64-18-6	target	--	17139284 17016423 10592235
Heme	--	--	target	--	17139284 17016423 10592235
12-Phenylheme	--	--	target	--	17139284 17016423
2-Phenylheme	--	--	target	--	17139284 17016423
1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone	--	--	target	--	10592235
1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE	--	--	target	--	10592235
Vitamin E	alpha-Tocopherol (see all 2)	59-02-9	enzyme	inducer	20153624
Verdoheme	--	--	target	--	--

10/133 Novoseek chemical compound relationships for HMOX1 gene (see all 133) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
biliverdin	96.6	388	15741166 (5), 18385824 (4), 17825497 (3), 15004156 (3) (see all 99)
snpp	89.6	51	10655786 (2), 17215323 (2), 19797297 (2), 9596945 (2) (see all 25)
cobalt protoporphyrin	89.5	77	20131233 (2), 16309584 (2), 17919492 (2), 12352873 (2) (see all 43)
zinc protoporphyrin	88.9	145	11222374 (7), 20021945 (3), 18665050 (3), 16804400 (2) (see all 63)
protoporphyrin ix	82	104	12591764 (2), 11238670 (2), 7545388 (1), 10655786 (1) (see all 70)
verdoheme	81.5	16	9063888 (2), 9054378 (2), 18331037 (2), 16154530 (1) (see all 8)
copp	80.2	83	17065227 (6), 17964723 (5), 19387321 (3), 15932518 (3) (see all 28)
iron	78.4	563	18774956 (8), 16439612 (6), 19777608 (6), 10872745 (5) (see all 99)
mesoporphyrin	76.2	13	12835114 (1), 11435909 (1), 10933875 (1), 15564944 (1) (see all 11)
sn mesoporphyrin	76	12	11053673 (1), 14614191 (1), 12933701 (1), 14600247 (1) (see all 7)

Search CenterWatch for drugs/clinical trials and news about HMOX1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HMOX1 gene:

NM_002133.2

Unigene Cluster for HMOX1:

Heme oxygenase (decycling) 1

Hs.517581 [show with all ESTs]

Unigene Representative Sequence: BG165629

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000412893 ENST00000216117(uc003ant.2) ENST00000481190 ENST00000494998

miRNA Products:		OriGene 3'-UTR Clone: HMOX1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HMOX1
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate HMOX1:
		hsa-miR-873 hsa-miR-525-5p hsa-miR-1205 hsa-miR-520a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: HMOX1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMOX1 (see all 7) OriGene shRNA RFP: HMOX1 OriGene siRNA: HMOX1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMOX1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMOX1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMOX1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HMOX1 (NM_002133)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMOX1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMOX1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMOX1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HMOX1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMOX1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMOX1

Additional cDNA sequence:

AF051791.1 AK313120.1 BC001491.2 BT019785.1 CR456505.1 CR541945.1 CR541968.1 GU187012.1

JF323038.1 M23041.1 M23042.1 X06985.1

12 DOTS entries:

DT.316089 DT.100826177 DT.100826183 DT.120670488 DT.100763288 DT.100772294 DT.91691570 DT.100036770

DT.100696678 DT.100736928 DT.120670441 DT.91842270

24/341 AceView cDNA sequences (see all 341):

BI835173 BP340016 CR541968 BM708071 BM710283 BU656972 BP341746 BX368461

CD673780 M23041 BX371115 AW664267 BQ926690 BM453474 CR615696 CB146156

W90397 CR600636 CR626132 CR622130 CR625992 CR617367 CR598003 CA306357

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for HMOX1 About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6a	·	6b	^	7
SP1:									-										-
SP2:									-
SP3:
SP4:

ECgene alternative splicing isoforms for HMOX1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HMOX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTGGGTGGG

About this image

HMOX1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epicardium

Spinal Neural Tube Cells

Neural Ectoderm

Brain

Meninges

Brain

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

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Category

Syncytiotrophoblast-like cells (Generation of syncyt...)

HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

See HMOX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HMOX1

SOURCE GeneReport for Unigene cluster: Hs.517581

UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601

Tissue specificity: Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level)

SABiosciences Expression via Pathway-Focused PCR Arrays including HMOX1 (see all 13):

Nephrotoxicity in human mouse rat

Cancer PathwayFinder in human mouse rat

Oxidative Stress in human mouse rat

Hypoxia Signaling Pathway in human mouse rat

Hepatotoxicity in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for HMOX1 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HMOX1¹	heme oxygenase (decycling) 1	67.83(n) 65.73(a)		396287 NM_205344.1 NP_990675.1
lizard (Anolis carolinensis)	Reptilia	HMOX1⁶	--	55(a)	1 ↔ 1	5(21485482-21495964)
African clawed frog (Xenopus laevis)	Amphibia	MGC68771²	hypothetical protein MGC68771	74.32(n)		BC060435.1
zebrafish (Danio rerio)	Actinopterygii	hmox1¹	heme oxygenase (decycling) 1	55.9(n) 50.19(a)		791518 NM_001127516.1 NP_001120988.1
fruit fly (Drosophila melanogaster)	Insecta	Ho⁶	Heme oxygenase	19(a)	1 → many	3R(7505481-7506698)

ENSEMBL Gene Tree for HMOX1 (if available)
TreeFam Gene Tree for HMOX1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for HMOX1 gene

HMOX2²

2 SIMAP similar genes for HMOX1 using alignment to 6 protein entries: HMOX1_HUMAN (see all proteins):

HO1 HMOX2

HMOX1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9619534^1,2	C,	--	18735631(+)	`gccacC/Tgcgcc`	1	--	us2k¹		3	NA NS	94
rs9619537^1,2	C	--	18736161(+)	`TGCCTC/TTGGGC`	1	--	us2k¹		1	NA	2
rs112096153^1,2	C,	--	18736392(+)	`TTATAT/-TTTGT`	1	--	us2k¹		1	CSA	2
rs74948886^1,2	F,	--	18736659(+)	`CCCGAG/ATTCTA`	1	--	us2k¹		1	WA	118
rs17879895^1,2	C,F,H,	--	18736822(+)	`GTGTCC/TCAGTC`	1	--	us2k¹		9	NS NA WA	1096
rs17879594^1,2	C,	--	18737085(+)	`GTGTGA/TGGAGG`	1	--	us2k¹		2	NS	92
rs56161244^1,2	C,F,	--	18737446(+)	`AAGGGT/CCATAT`	1	--	us2k¹		1	NA	120
rs9282700^1,2	C,F	--	18737599(+)	`GCTCCG/AGCAGT`	1	--	ut5¹ ese³		5	MN	396
rs9282701^1,2	C,F,H,	--	18737671(+)	`GAGCCC/TAGCAC`	1	--	ut5¹ ese³		11	MN NS EA NA	1050
rs77377445^1,2		--	18738089(+)	`CATCTG/ATCCCT`	1	--	int¹		2	CSA WA	120

HapMap Linkage Disequilibrium report for HMOX1 (35776354 - 35790207 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HMOX1
1 CNV: 36020
Human Gene Mutation Database (HGMD): HMOX1

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HMOX1 for disorders           About GeneDecksing

OMIM gene information: 141250
OMIM disorders: 606963
UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601

Defects in HMOX1 are the cause of heme oxygenase 1 deficiency (HMOX1D) [MIM:614034]. A disease characterized

by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis,

coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features

include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and

hepatomegaly

20/196 diseases for HMOX1 (see all 196): About MalaCards

heme oxygenase-1 deficiency spinal cord injury adult-onset still's disease end stage renal failure

erythropoietic protoporphyria central retinal artery occlusion retinal artery occlusion iron overload

arteriovenous malformation bronchiolitis obliterans congenital diaphragmatic hernia pulmonary arteriovenous malformation

arthus reaction pre-eclampsia abdominal aortic aneurysm traumatic brain injury

oral submucous fibrosis porphyria type 2 diabetes mellitus aortic aneurysm

7 diseases from the University of Copenhagen DISEASES database for HMOX1:

Vascular disease Brain disease Kidney disease Toxic encephalopathy

Lung disease Heart disease Cancer

10/95 Novoseek disease relationships for HMOX1 gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cell damage	60.3	40	15378604 (4), 11707736 (2), 16971418 (2), 19245827 (2) (see all 24)
inflammation	59.9	186	11135063 (4), 19076005 (4), 17384141 (3), 16234431 (3) (see all 99)
shock	58.2	154	15618017 (3), 8645700 (3), 8652820 (2), 18024796 (2) (see all 95)
necrosis	49.9	82	18262556 (2), 20193368 (2), 9530200 (2), 12894236 (1) (see all 53)
ischemia	47.7	63	17522519 (3), 16775600 (2), 15996234 (2), 20222175 (2) (see all 40)
neurodegenerative diseases	46	21	12835114 (2), 18289070 (2), 9003061 (1), 19457088 (1) (see all 16)
atherosclerosis	42.9	46	16999951 (3), 18769232 (2), 18289069 (2), 13678532 (1) (see all 29)
hemolysis intravascular	39.7	2	19380867 (1), 20001631 (1)
cerebral vasospasm	37.3	13	19686725 (4), 11808338 (2), 14657544 (1), 15571165 (1) (see all 5)
porphyria acute intermittent	35.8	1	17973866 (1)

Genetic Association Database (GAD): HMOX1
Human Genome Epidemiology (HuGE) Navigator: HMOX1 (126 documents)

Export disorders for HMOX1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HMOX1 gene, integrated from 9 sources (see all 1824):
(articles sorted by number of sources associating them with HMOX1)

Utopia: connect your pdf to the dynamic
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The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2, 3} Dunham I....O'Brien K.P. (1999)
Heme oxygenase-1 genotype and restenosis after balloon angioplasty: a novel vascular protective factor. (PubMed id 15028349)^{1, 4, 9} Schillinger M....Wagner O. (2004)
Length polymorphism in heme oxygenase-1 is associated with arteriovenous fistula patency in hemodialysis patients. (PubMed id 16374439)^{1, 4, 9} Lin C.C....Chung M.Y. (2006)
Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism. (PubMed id 15688187)^{1, 4, 9} Kikuchi A....Sasaki H. (2005)
Clinical restenosis after coronary stent implantation is associated with the heme oxygenase-1 gene promoter polymorphism and the heme oxygenase-1 +99G/C variant. (PubMed id 16020495)^{1, 4, 9} Gulesserian T....Huber K. (2005)
The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting. (PubMed id 16232329)^{1, 4, 9} Li P....Humphries S.E. (2005)
Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty. (PubMed id 11718398)^{1, 4, 9} Exner M....Wagner O. (2001)
Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar. (PubMed id 16249618)^{1, 4, 9} Takeda M....Hirayama K. (2005)
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. (PubMed id 15817713)^{1, 4, 9} Hersh C.P....Silverman E.K. (2005)
The size of a microsatellite polymorphism of the haem oxygenase 1 gene is associated with idiopathic recurrent miscarriage. (PubMed id 14981149)^{1, 4, 9} Denschlag D....Wagner O. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3162	HGNC: 5013	AceView: HMOX1	Ensembl:ENSG00000100292	euGenes: HUgn3162
ECgene: HMOX1	Kegg: 3162	H-InvDB: HMOX1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HMOX1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HMOX1	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/hmox1/

Intellectual Property for HMOX1 gene
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Patent Information for HMOX1 gene:
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GeneCards and IP:
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HMOX1 Gene

heme oxygenase (decycling) 1

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HMOX1 Gene

heme oxygenase (decycling) 1

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