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HMOX1 Gene

protein-coding GIFtS: 71

GC22P034101

heme oxygenase (decycling) 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.14.99.3 ^³
HO ^³
HO-1 ^¹, ², ³
HO1 ^³
HSP32 ^²
OTTHUMP00000028925 ^²
bK286B10 ^¹, ²

Descriptions
heme oxygenase (decycling) 1 ^²
heme oxygenase (decyclizing) 1 ^²

External Ids
HGNC: 5013¹
Entrez Gene: 3162²
UniProtKB: P09601³
Ensembl: ENSG00000100292⁷

Search outside databases for aliases for HMOX1 gene

Previous GC identifer: GC22P032473

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HMOX1:

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is

subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative

neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme

substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive

heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq]

UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601

Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin.

Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological

conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes

are sequestrated and destroyed

Gene Wiki entry for HMOX1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HMOX1 gene

Entrez Gene cytogenetic band: 22q12|22q13.1 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q12

HMOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P034101: (about GC identifiers)

Start:	34,107,087 bp from pter
End:	34,120,194 bp from pter
Size:	13,108 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601 (See protein sequence)

Recommended Name: Heme oxygenase 1

Size: 288 amino acids; 32819 Da

Subcellular location: Microsome. Endoplasmic reticulum

PDB structures from and Proteopedia :

1N3U (3D)

1N45 (3D)

1NI6 (3D)

1OYK (3D)

1OYL (3D)

1OZE (3D)

1OZL (3D)

1OZR (3D)

1OZW (3D)

1S13 (3D)

1S8C (3D)

1T5P (3D)

1TWN (3D)

1TWR (3D)

1XJZ (3D)

1XK0 (3D)

1XK1 (3D)

1XK2 (3D)

1XK3 (3D)

3CZY (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002124.1

ENSEMBL proteins:

ENSP00000216117

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant HMOX1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Heme Oxygenase 1)
	Human Recombinant Proteins from Abnova (HMOX1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	18307065
GO:0005624	membrane fraction	TAS	3345742
GO:0005634	nucleus	IEA	--
GO:0005730	nucleolus	IEA	--
GO:0005783	endoplasmic reticulum	TAS	3345742

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Antibodies for HMOX1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of HMOX1
	Sigma-Aldrich Antibodies for HMOX1
	R&D Systems Antibodies for HMOX1 (HO-1/HMOX1/HSP32)
	Antibodies from Abcam (Heme Oxygenase 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HMOX1)
	Novus Biologicals Antibodies for HMOX1

Assays for HMOX1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for HMOX1 (HO-1/HMOX1/HSP32) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P09601

ProtoNet protein and cluster: P09601

1 Blocks protein family: IPB002051 Heme oxygenase

UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601

Similarity: Belongs to the heme oxygenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HMOX1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HMOX1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002133

Applied Biosystems Silencer® siRNAs for HMOX1

Sigma-Aldrich siRNA and siRNA Panels for HMOX1

Sigma-Aldrich shRNA Panels and shRNA for HMOX1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HMOX1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002133
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002133
untagged cDNA clones in CMV expression vector (see all 2): NM_002133

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002133

UniProtKB/Swiss-Prot: HMOX1_HUMAN, P09601

Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin.

Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological

conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes

are sequestrated and destroyed

Catalytic activity: Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O

Induction: Heme oxygenase 1 activity is highly inducible by its substrate heme and by various

non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA

Enzyme Number (IUBMB): EC 1.14.99.3

Genatlas biochemistry entry for HMOX1:

heme oxygenase-1,rate limiting enzyme in the degradation of heme to biliverdin,inducible

form,ubiquitously expressed following induction by several stresses,potent anti-inflammatory

proteins whenever oxidation injury takes place

15/16 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Hmox1) (see all 16 ):

	behavior/neurological	cellular	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal	lethality-prenatal/perinatal
life span-post-weaning/aging	liver/biliary system	muscle	renal/urinary system	reproductive system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004392	heme oxygenase (decyclizing) activity	TAS	9884342
GO:0004630	phospholipase D activity	IEA	--
GO:0004871	signal transducer activity	IMP	12761501
GO:0016491	oxidoreductase activity	IEA	--
GO:0019899	enzyme binding	ISS	15516695

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/10 Sigma-Aldrich "Your Favorite Gene" Pathways for HMOX1 (Your Favorite Gene powered by Ingenuity) (see all 10 )

IL-10 Signaling
IL-8 Signaling
Glycerophospholipid Metabolism
Xenobiotic Metabolism Signaling
NRF2-mediated Oxidative Stress Response

GeneDecks HMOX1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for HMOX1

5/101 Interacting proteins for HMOX1 (ENSP00000216117³) via UniProtKB, MINT, and/or STRING (see all 101 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIF1A	ENSP00000338018³	STRING (score=.995)
MAPK14	ENSP00000229794³	STRING (score=.991)
FOS	ENSP00000306245³	STRING (score=.99)
AKT1	ENSP00000270202³	STRING (score=.986)
POR	ENSP00000265302³	STRING (score=.976)

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5/32 Gene Ontology (GO) biological process terms (links to tree view) (see all 32 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0001935	endothelial cell proliferation	TAS	12239590
GO:0002246	healing during inflammatory response	IMP	9884342
GO:0002686	negative regulation of leukocyte migration	TAS	14525760
GO:0006788	heme oxidation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for HMOX1

Browse Small Molecules at Sigma-Aldrich

Compounds for HMOX1 available from Tocris Bioscience

Compound	Action	CAS number
Zinc protoporphyrin IX	Heme oxygenase and guanylyl cyclase inhibitor	[15442-64-5]
Tin protoporphyrin IX dichloride	Heme oxygenase inhibitor	[14325-05-4]

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10/33 Novoseek chemical compound relationships for HMOX1 gene (see all 33 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
biliverdin	96.52	338	15741166 (5), 18385824 (4), 17825497 (3), 15004156 (3) (see all 99)
snpp	89.97	47	10655786 (2), 17215323 (2), 10328571 (2), 9596945 (2) (see all 23)
cobalt protoporphyrin	88.58	64	16309584 (2), 17919492 (2), 17665394 (2), 18042465 (2) (see all 34)
protoporphyrin ix	81.78	97	12591764 (2), 11238670 (2), 7545388 (1), 10655786 (1) (see all 65)
verdoheme	79.63	16	9063888 (2), 9054378 (2), 18331037 (2), 16154530 (1) (see all 8)
copp	78.56	73	17065227 (6), 17964723 (5), 19387321 (3), 15932518 (3) (see all 23)
iron	78.11	475	16439612 (6), 10872745 (5), 19250338 (5), 11389189 (4) (see all 99)
mesoporphyrin	74.69	9	12835114 (1), 11435909 (1), 10933875 (1), 15564944 (1) (see all 9)
haem	73.60	77	12622689 (5), 10839994 (4), 10833368 (3), 9063888 (2) (see all 33)
azalanstat	71.54	2	15713406 (1), 16309566 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HMOX1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HMOX1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002133

Sigma-Aldrich siRNA and siRNA Panels for HMOX1

Sigma-Aldrich shRNA Panels and shRNA for HMOX1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002133

REFSEQ mRNAs for HMOX1 gene:

NM_002133.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002133

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002133
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002133
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002133

Additional cDNA sequence:

AF051791.1 AK313120.1 BC001491.2 BT019785.1 CR456505.1 CR541945.1 CR541968.1 CR590034.1

CR592402.1 CR594865.1 CR595835.1 CR596243.1 CR598003.1 CR600636.1 CR601640.1 CR603909.1

CR605543.1 CR609687.1 CR609692.1 CR611293.1 CR611539.1 CR612044.1 CR612068.1 CR615425.1

CR615434.1 CR615696.1 CR615878.1 CR615893.1 CR617367.1 CR617513.1 CR622130.1 CR623238.1

CR623301.1 CR623799.1 CR624289.1 CR625550.1 CR625992.1 CR626132.1 M23041.1 M23042.1

X06985.1

12 DOTS entries:

DT.316089 DT.100826177 DT.100826183 DT.120670488 DT.100763288 DT.100772294 DT.91691570 DT.100036770

DT.100696678 DT.100736928 DT.120670441 DT.91842270

24/341 AceView cDNA sequences (see all 341 ):

CA306658 BQ710923 CR590034 CR615893 AI754564 CR609692 CR624289 M23041

BM706131 BF528933 CR615878 AU279619 CR592402 CD672139 CR598003 CR594865

CR601640 CR615696 BI835173 BP341746 CR615434 CR611539 BU731927 AJ712025

highest scoring ESTs for HMOX1:

AA059444 AA187560 AA187582 AA454630 AA455893 AA456241 AA456727 AA682678 AA769700 AA845219

Unigene Cluster for HMOX1:

Heme oxygenase (decycling) 1

Hs.517581 [show with all ESTs]

Unigene Representative Sequence: BG165629

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for HMOX1

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6a	·	6b	^	7
SP1:									-										-
SP2:									-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for HMOX1

1 Ensembl transcript including schematic representation:

ENST00000216117

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HMOX1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HMOX1

¹ / ² / ³

3 probe-sets matching HMOX1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33802_at²^{, 3}	U95-A	4	1.00	0.93	1.00	1.00	Z82244	0.20	1.00	0.72	1
203665_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002133	0.60	1.00	0.82	1
203665_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks HMOX1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CGTGGGTGGG

SOURCE GeneReport for Unigene cluster: Hs.517581
Expression variation in blood from EXPOLDB for HMOX1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HMOX1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HMOX1¹	--	heme oxygenase (decycling) 1	87.26(n) 86.43(a)	442987 XM_848052.1 XP_853145.1
chimpanzee (Pan troglodytes)	HMOX1¹	--	heme oxygenase (decycling) 1	99.54(n) 100(a)	470195 XM_525579.2 XP_525579.2
cow (Bos taurus)	HMOX1¹	--	heme oxygenase (decycling) 1	85.88(n) 84.03(a)	513221 NM_001014912.1 NP_001014912.1
rat (Rattus norvegicus)	Hmox1¹	--	heme oxygenase (decycling) 1	81.48(n) 80.21(a)	24451 NM_012580.2 NP_036712.1
mouse (Mus musculus)	Hmox1^{1, 5}	8 (35.00 cM)⁵	heme oxygenase (decycling) 1^{1, 5}	82.18(n)¹ 82.29(a)¹	15368¹ NM_010442.1¹ NP_034572.1¹ AA186175⁵ AA407518⁵ (see all 31)

About this table Species with no ortholog for HMOX1

ENSEMBL Gene Tree for HMOX1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HMOX1 gene

HMOX2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/198 NCBI SNPs in HMOX1 are shown (see all 198 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 76)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2071746^1,2	A,C,F,H	34106672(+)	`AGGCTT/ATTGCT`	1	--	ng5¹		14	EU EA WA NS MN	2404
--	rs9619536^1,2	A,C,F	34105550(+)	`ttttcG/Agggaa`	1	--	ng5¹		2	NS	88
	rs2071747^1,2	C,F,H	34107185(+)	`AACCCG/CACAGG`	1	H/D	mis¹		17	MN CSAM EA NS EU WA	2566
--	rs11555832^1,2	C,F	34119869(-)	`GGGTGT/CCTTCC`	1	--	ut3¹ ese³		12	NA NS	1830
--	rs9282702^1,2	F,H	34112850(+)	`CATCCC/TCTACA`	1	P/L	mis¹ ese³		9	MN CSAM EA EU WA	814
	rs17880288^1,2	C,F	34120323(+)	`TGAGAA/TTACAG`	1	--	ng3¹		9	NS	1700
--	rs12160039^1,2	C,F	34120285(+)	`AGAAGT/CGGTGA`	1	--	ng3¹		2	NS	90
--	rs3761439^1,2	C,F	34105889(+)	`GAGACG/AGGGTC`	1	--	ng5¹		2	NS	76
	rs5755721^1,2	H	34120168(+)	`CTTTTG/TTGTGA`	1	--	ut3¹ ese³		4	EU EA WA	420
	rs17879895^1,2	F	34106307(+)	`GTGTCC/TCAGTC`	1	--	ng5¹		2	NS	88

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HapMap Linkage Disequilibrium images for HMOX1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 141250

10/97 Novoseek disease relationships for HMOX1 gene (see all 97 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cell damage	59.32	38	15378604 (4), 11707736 (2), 16971418 (2), 19245827 (2) (see all 23)
shock	58.09	141	15618017 (3), 8645700 (3), 8652820 (2), 18024796 (2) (see all 87)
inflammation	57.50	161	11135063 (4), 19076005 (4), 17384141 (3), 16234431 (3) (see all 89)
neurodegenerative diseases	46.91	15	12835114 (2), 18289070 (2), 9003061 (1), 11053673 (1) (see all 12)
ischemia	46.41	56	17522519 (3), 16775600 (2), 15996234 (2), 10566971 (2) (see all 35)
necrosis	45.97	68	18262556 (2), 9530200 (2), 12894236 (1), 15258907 (1) (see all 47)
atherosclerosis	41.38	41	16999951 (3), 18769232 (2), 18289069 (2), 13678532 (1) (see all 25)
porphyria acute intermittent	37.98	1	17973866 (1)
cerebral vasospasm	37.09	7	11808338 (2), 14657544 (1), 15571165 (1), 18490853 (1)
porphyria hepatic	33.71	1	11343251 (1)

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Human Gene Mutation Database: HMOX1
Genetic Association Database: HMOX1
Human Genome Epidemiology Navigator: HMOX1 (79 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1312 PubMed articles for HMOX1 gene (see all 1312 ):

The DNA sequence of human chromosome 22. (PubMed id 10591208)^{2, 3, 4} Dunham I....O'Brien K.P. (1999)
Heme oxygenase-1 genotype and restenosis after balloon angioplasty: a novel vascular protective factor. (PubMed id 15028349)^{1, 3, 6} Schillinger M....Wagner O. (2004)
Length polymorphism in heme oxygenase-1 is associated with arteriovenous fistula patency in hemodialysis patients. (PubMed id 16374439)^{1, 3, 6} Lin C.C....Chung M.Y. (2006)
Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism. (PubMed id 15688187)^{1, 3, 6} Kikuchi A....Sasaki H. (2005)
Clinical restenosis after coronary stent implantation is associated with the heme oxygenase-1 gene promoter polymorphism and the heme oxygenase-1 +99G/C variant. (PubMed id 16020495)^{1, 3, 6} Gulesserian T....Huber K. (2005)
The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting. (PubMed id 16232329)^{1, 3, 6} Li P....Humphries S.E. (2005)
Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty. (PubMed id 11718398)^{1, 3, 6} Exner M....Wagner O. (2001)
Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar. (PubMed id 16249618)^{1, 3, 6} Takeda M....Hirayama K. (2005)
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. (PubMed id 15817713)^{1, 3, 6} Hersh C.P....Silverman E.K. (2005)
Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis. (PubMed id 15885363)^{1, 3, 6} Osterreicher C.H....Ferenci P. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3162	HGNC: 5013	AceView: HMOX1	Ensembl:ENSG00000100292	euGenes: HUgn3162
ECgene: HMOX1	H-InvDB: HMOX1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for HMOX1	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/hmox1/

Licensable Technologies for HMOX1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HMOX1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HMOX1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HMOX1		Antibodies for HMOX1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HMOX1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HMOX1)
	Antibodies (HMOX1)
	Chimera RNAi (HMOX1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Heme Oxygenase 1)
	Antibodies (Heme Oxygenase 1)

Search OriGene for HMOX1

Tocris compounds for HMOX1

	Drugs for HMOX1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HMOX1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
HMOX1 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

HMOX1 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for HMOX1

Summaries
for HMOX1

Genomic Location
for HMOX1

Proteins
for HMOX1

Protein Domains/
Families
for HMOX1

Gene Function
for HMOX1

Pathways & Interactions
for HMOX1

Drugs & Compounds
for HMOX1

Transcripts
for HMOX1

Expression
for HMOX1

Orthologs
for HMOX1

Paralogs
for HMOX1

SNPs/Variants
for HMOX1

Disorders & Mutations
for HMOX1

Medical News
for HMOX1

Publications
for HMOX1

Search for HMOX1

Genome Databases showing HMOX1

Other Databases showing HMOX1

Specialized Databases showing HMOX1

Licensable Technologies
for HMOX1

Services
for HMOX1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HMOX1 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor HMOX1

Summariesfor HMOX1

Genomic Locationfor HMOX1

Proteinsfor HMOX1

Protein Domains/Familiesfor HMOX1

Gene Functionfor HMOX1

Pathways & Interactionsfor HMOX1

Drugs & Compoundsfor HMOX1

Transcriptsfor HMOX1

Expression for HMOX1

Orthologsfor HMOX1

Paralogsfor HMOX1

SNPs/Variantsfor HMOX1

Disorders & Mutationsfor HMOX1

Medical Newsfor HMOX1

Publicationsfor HMOX1

Search for HMOX1

Genome Databases showing HMOX1

Other Databases showing HMOX1

Specialized Databases showing HMOX1

Licensable Technologiesfor HMOX1

Servicesfor HMOX1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HMOX1

Summaries
for HMOX1

Genomic Location
for HMOX1

Proteins
for HMOX1

Protein Domains/
Families
for HMOX1

Gene Function
for HMOX1

Pathways & Interactions
for HMOX1

Drugs & Compounds
for HMOX1

Transcripts
for HMOX1

Expression
for HMOX1

Orthologs
for HMOX1

Paralogs
for HMOX1

SNPs/Variants
for HMOX1

Disorders & Mutations
for HMOX1

Medical News
for HMOX1

Publications
for HMOX1

Licensable Technologies
for HMOX1

Services
for HMOX1