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HMMR Gene

protein-coding   GIFtS: 59
GCID: GC05P162887

Hyaluronan-Mediated Motility Receptor (RHAMM)

  See HMMR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hyaluronan-Mediated Motility Receptor (RHAMM)1 2     RHAMM2 3
Intracellular Hyaluronic Acid-Binding Protein2 3     CD1682
Receptor For Hyaluronan-Mediated Motility2 3     Hyaluronan Mediated Motility Receptor2
IHABP2 3     CD168 Antigen3

External Ids:    HGNC: 50121   Entrez Gene: 31612   Ensembl: ENSG000000725717   OMIM: 6009365   UniProtKB: O753303   

Export aliases for HMMR gene to outside databases

Previous GC identifers: GC05P163090 GC05P163480 GC05P162822 GC05P162868 GC05P162820 GC05P157987


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HMMR Gene:
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with
other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of
breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this
gene. (provided by RefSeq, Dec 2008)

GeneCards Summary for HMMR Gene:
HMMR (hyaluronan-mediated motility receptor (RHAMM)) is a protein-coding gene. Diseases associated with HMMR include chronic graft versus host disease, and breast cancer. GO annotations related to this gene include hyaluronic acid binding.

UniProtKB/Swiss-Prot: HMMR_HUMAN, O75330
Function: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins,
including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in
regulating extracellular-regulated kinase (ERK) activity

Gene Wiki entry for HMMR (Hyaluronan-mediated motility receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HMMR gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   c-Myb   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHMMR promoter sequence
   Search Chromatin IP Primers for HMMR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMMR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34   Ensembl cytogenetic band:  5q34   HGNC cytogenetic band: 5q34

HMMR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMMR gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P162887:  view genomic region     (about GC identifiers)

Start:
162,887,209 bp from pter      End:
162,918,951 bp from pter
Size:
31,743 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HMMR_HUMAN, O75330 (See protein sequence)
Recommended Name: Hyaluronan mediated motility receptor  
Size: 724 amino acids; 84100 Da
Subunit: Subunit of the HARC complex
Secondary accessions: A8K3G2 B4E114 D3DQK9 D3DQL0 E9PCS0 Q32N02 Q92767
Alternative splicing: 4 isoforms:  O75330-1   O75330-2   O75330-3   O75330-4   

Explore the universe of human proteins at neXtProt for HMMR: NX_O75330

Explore proteomics data for HMMR at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HMMR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001136028.1  NP_001136029.1  NP_036616.2  NP_036617.2  

    ENSEMBL proteins: 
     ENSP00000428481   ENSP00000428406   ENSP00000185942   ENSP00000377492   ENSP00000402673  
     ENSP00000351554  
    Reactome Protein details: O75330

    HMMR Human Recombinant Protein Products:

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    Novus Biologicals HMMR Protein
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HMMR

     
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    antibodies-online proteins for HMMR (2 products) 

     
    antibodies-online peptides for HMMR

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    HMMR Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for HMMR
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    antibodies-online kits for HMMR (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    1 InterPro protein domain:
     IPR026203 IHABP

    Graphical View of Domain Structure for InterPro Entry O75330

    ProtoNet protein and cluster: O75330


    Find genes that share domains with HMMR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMMR_HUMAN, O75330
    Function: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins,
    including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in
    regulating extracellular-regulated kinase (ERK) activity

         Genatlas biochemistry entry for HMMR:
    hyaluronan-mediated motility receptor,involved in signal transduction via Src tyrosine kinase family,expressed in
    the cytoplasm,nucleus,and cell surface,five isoforms (58,60,64,70,84kDa),regulating cell motility and cell cycle

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005540hyaluronic acid binding IEA--
         
    Find genes that share ontologies with HMMR           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hmmr):
     reproductive system  tumorigenesis 

    Find genes that share phenotypes with HMMR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hmmrtm1Baa for HMMR

       genOway: Develop your customized and physiologically relevant rodent model for HMMR

    miRNA
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    miRTarBase miRNAs that target HMMR:
    hsa-mir-106b-5p (MIRT044370), hsa-mir-98-5p (MIRT027466), hsa-mir-215-5p (MIRT024628), hsa-mir-93-3p (MIRT038799), hsa-mir-192-5p (MIRT026177)

    Block miRNA regulation of human, mouse, rat HMMR using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate HMMR:
    hsa-miR-3163 hsa-miR-4330 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidHMMR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HMMR

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): HMMR (NM_012484)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMMR

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMMR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HMMR_HUMAN, O75330: Cell surface. Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    cytosol2
    nucleus2
    extracellular1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IEA--

    Find genes that share ontologies with HMMR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HMMR About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Integrin Pathway
    FAK1 Signaling0.67
    3Apoptotic Pathways in Synovial Fibroblasts
    Glioma Invasiveness0.64
    4Metabolism
    Metabolism0.38
    5Focal adhesion
    ECM-receptor interaction0.31


    Find genes that share SuperPaths with HMMR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HMMR
        Glioma Invasiveness
    FAK1 Signaling


    1 Reactome Pathway for HMMR
        Hyaluronan uptake and degradation


    1 Kegg Pathway  (Kegg details for HMMR):
        ECM-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including HMMR: 
              Lung Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HMMR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for HMMR (O753302, 3 ENSP000003774924) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    MAPK3P273613, ENSP000002630254I2D: score=3 STRING: ENSP00000263025
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030212hyaluronan metabolic process TAS--
    GO:0030214hyaluronan catabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with HMMR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HMMR

    2 HMDB Compounds for HMMR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronanhyaluronic acid (see all 13)9004-61-9--
    Hyaluronic acidhyaluronic acid 9004-61-9--

    5 Novoseek inferred chemical compound relationships for HMMR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyaluronic acid 84.9 87 8567680 (6), 8314845 (2), 1724753 (2), 19601984 (2) (see all 38)
    chondroitin sulfate 20 1 9601098 (1)
    tyrosine 7.53 5 8750188 (2), 12793201 (1), 1380898 (1)
    pge2 0 1 11943733 (1)
    heparin 0 14 7534313 (7), 9601098 (1)



    Find genes that share compounds with HMMR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HMMR gene (4 alternative transcripts): 
    NM_001142556.1  NM_001142557.1  NM_012484.2  NM_012485.2  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520345 ENST00000522094 ENST00000353866 ENST00000393915(uc003lzh.3 uc003lzf.3 uc003lzg.3 uc011dem.2)
    ENST00000432118 ENST00000521108 ENST00000358715 ENST00000517936
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    hsa-miR-3163 hsa-miR-4330 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidHMMR 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat HMMR
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    Selected AceView cDNA sequences (see all 172):

    BE892436 AA743743 BQ027031 AA909904 AA262978 AA687269 CB132559 BM764295 
    AA831946 BE042983 BQ000586 AF032862 BM680960 AI088336 AW057729 AA593010 
    BM772368 AA912764 AA804515 CR601287 BE327167 NM_012484 AI209041 BM725946 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HMMR (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19
    SP1:                                -                                                                                                               
    SP2:                                -                                                                                                               
    SP3:                                -     -                                                                                                         
    SP4:        -     -                 -     -                                                                                                         
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for HMMR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HMMR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTACTCAGC
    HMMR Expression
    About this image


    HMMR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells (family)
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Gonad
             XX Germ Cells Ovigerous Cord
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
    HMMR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMMR Protein Expression

    UniProtKB/Swiss-Prot: HMMR_HUMAN, O75330
    Tissue specificity: Expressed in breast cancer cell lines and in normal breast tissue

        Pathway & Disease-focused RT2 Profiler PCR Array including HMMR: 
              Lung Cancer in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMMR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HMMR gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmmr1 , 5 hyaluronan mediated motility receptor (RHAMM)1, 5 74.52(n)1
    71.51(a)1
      11 (24.40 cM)5
    153661  NM_013552.21  NP_038580.21 
     407013955 
    chicken
    (Gallus gallus)
    Aves HMMR1 hyaluronan-mediated motility receptor (RHAMM) 62.28(n)
    52.12(a)
      416163  XM_414495.4  XP_414495.4 
    lizard
    (Anolis carolinensis)
    Reptilia HMMR6
    hyaluronan-mediated motility receptor (RHAMM)
    46(a)
    1 ↔ 1
    1(108079424-108111805)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.227202 Xenopus laevis transcribed sequence with weak similarity more 74.32(n)    AW646000.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmmr2 hyaluronan mediated motility receptor 68.28(n)   322012  AY423004.1 


    ENSEMBL Gene Tree for HMMR (if available)
    TreeFam Gene Tree for HMMR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HMMR (see all 684)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs709970521,2
    C--157992242(-) AGACC-/AG    
       CCT
    /T
    AGCCT
    4 -- int11NA 2
    rs1139030811,2
    C--162892558(+) TGGGC-/AGGCT 
            
    AGGCT
    4 -- int11Minor allele frequency- AGGCT:0.00CSA 2
    rs358999061,2
    C--162895808(+) AGGTT-/CCCCCC 4 -- int10--------
    rs1153187311,2
    F--163114409(+) GGGACC/TCTGTC 4 -- us2k11Minor allele frequency- T:0.03WA 118
    rs2006519091,2
    --163114421(+) AATAA-/ATATATA 4 -- us2k10--------
    rs1125894031,2
    C--163114429(+) TATAT-/ATTTTT 4 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1830154121,2
    --163114577(+) GTCTAC/TACGTA 4 -- us2k10--------
    rs725470771,2
    C--163114646(+) AATTT-/TTAATC 4 -- us2k10--------
    rs58728231,2
    C--163114647(+) ATTTA-/TAATCG 4 -- us2k1 tfbs31Minor allele frequency- T:0.00CSA 2
    rs2992881,2
    C,F,H--163114669(+) CATTGT/GTGAGG 4 -- us2k111Minor allele frequency- G:0.35NS EA NA WA 780

    HapMap Linkage Disequilibrium report for HMMR (162887209 - 162918951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HMMR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524084CNV Loss19592680
    nsv519801CNV Loss19592680
    nsv830538CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HMMR
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600936   
    OMIM disorders: 114480  
    10 diseases for HMMR:    
    About MalaCards
    chronic graft versus host disease    breast cancer    nodular basal cell carcinoma    breast cancer susceptibility
    ossifying fibroma    fibrosarcoma    b-cell chronic lymphocytic leukemia    ovarian cancer
    acute myeloid leukemia    pancreatic cancer


    Find genes that share disorders with HMMR           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HMMR gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrosarcoma 36 2 8750188 (1), 7541721 (1)
    leukemia hairy cell 35.4 4 7678518 (2), 7529076 (1)
    metastasis 28.6 16 9533523 (3), 18174258 (2), 11029494 (1), 12469144 (1) (see all 10)
    tumors 28.1 29 11029494 (4), 18971636 (2), 9533523 (2), 11716065 (1) (see all 18)
    myeloma 27 2 15705883 (1), 7529076 (1)
    myxoma 25.3 2 1710472 (1), 2035257 (1)
    cancer 17.7 13 18174258 (2), 11029494 (1), 12469144 (1), 15705883 (1) (see all 9)
    leukemia 16.3 1 19724689 (1)
    breast carcinoma 8.39 3 8750188 (1), 9601098 (1), 9533523 (1)
    primary tumor 3.25 3 9533523 (3)

    Genetic Association Database (GAD): HMMR
    Human Genome Epidemiology (HuGE) Navigator: HMMR (2 documents)

    Export disorders for HMMR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for HMMR gene, integrated from 10 sources (see all 172):
    (articles sorted by number of sources associating them with HMMR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells. (PubMed id 9601098)1, 2, 9 Assmann V.... Hart I.R. (J. Cell Sci. 1998)
    2. Hyaluronan-mediated motility receptor gene single nucleotide polymorphisms and risk of breast cancer. (PubMed id 19064580)1, 4, 9 Kalmyrzaev B....Dunning A.M. (amp 2008)
    3. The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains. (PubMed id 8890751)1, 2 Wang C.... Turley E.A. (Gene 1996)
    4. RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53. (PubMed id 18971636)1, 9 Sohr S. and Engeland K. (Cell Cycle 2008)
    5. Regulated expression of a receptor for hyaluronan-mediated motility on human thymocytes and T cells. (PubMed id 7683315)1, 9 Pilarski L.M....Turley E.A. (J. Immunol. 1993)
    6. Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas. (PubMed id 19424574)1, 9 Shigeishi H....Kamata N. (Int. J. Oncol. 2009)
    7. The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. (PubMed id 17392272)1, 9 Hamilton S.R....Turley E.A. (J. Biol. Chem. 2007)
    8. Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity. (PubMed id 15705883)1, 9 Maxwell C.A....Reiman T. (Cancer Res. 2005)
    9. RHAMM (CD168) is overexpressed at the protein level and may constitute an immunogenic antigen in advanced prostate cancer disease. (PubMed id 19724689)1, 9 Gust K.M....Ringhoffer M. (Neoplasia 2009)
    10. The human and mouse receptors for hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11. (PubMed id 8595891)1, 9 Spicer A.P....McDonald J.A. (Genomics 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3161 HGNC: 5012 AceView: HMMR Ensembl:ENSG00000072571 euGenes: HUgn3161
    ECgene: HMMR Kegg: 3161 H-InvDB: HMMR

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HMMR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HMMR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HMMR gene:
    Search GeneIP for patents involving HMMR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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