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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HMMR Gene

protein-coding   GIFtS: 63
GCID: GC05P162887

Hyaluronan-Mediated Motility Receptor (RHAMM)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hyaluronan-Mediated Motility Receptor (RHAMM)1 2     RHAMM2 3
Intracellular Hyaluronic Acid-Binding Protein2 3     CD1682
Receptor For Hyaluronan-Mediated Motility2 3     Hyaluronan Mediated Motility Receptor2
IHABP2 3     CD168 Antigen3

External Ids:    HGNC: 50121   Entrez Gene: 31612   Ensembl: ENSG000000725717   OMIM: 6009365   UniProtKB: O753303   

Export aliases for HMMR gene to outside databases

Previous GC identifers: GC05P163090 GC05P163480 GC05P162822 GC05P162868 GC05P162820 GC05P157987


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HMMR Gene:
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with
other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of
breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this
gene. (provided by RefSeq, Dec 2008)

GeneCards Summary for HMMR Gene: 
HMMR (hyaluronan-mediated motility receptor (RHAMM)) is a protein-coding gene. Diseases associated with HMMR include nodular basal cell carcinoma, and breast cancer susceptibility, and among its related super-pathways are Metabolism of carbohydrates and Hyaluronan metabolism. GO annotations related to this gene include hyaluronic acid binding.

UniProtKB/Swiss-Prot: HMMR_HUMAN, O75330
Function: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins,
including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in
regulating extracellular-regulated kinase (ERK) activity

Gene Wiki entry for HMMR (Hyaluronan-mediated motility receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HMMR gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   c-Myb   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHMMR promoter sequence
   Search SABiosciences Chromatin IP Primers for HMMR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMMR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34   Ensembl cytogenetic band:  5q34   HGNC cytogenetic band: 5q34

HMMR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMMR gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P162887:  view genomic region     (about GC identifiers)

Start:
162,887,175 bp from pter      End:
162,918,951 bp from pter
Size:
31,777 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HMMR_HUMAN, O75330 (See protein sequence)
Recommended Name: Hyaluronan mediated motility receptor  
Size: 724 amino acids; 84100 Da
Subunit: Subunit of the HARC complex
Subcellular location: Cell surface. Cytoplasm (By similarity)
Secondary accessions: A8K3G2 B4E114 D3DQK9 D3DQL0 E9PCS0 Q32N02 Q92767
Alternative splicing: 4 isoforms:  O75330-1   O75330-2   O75330-3   O75330-4   

Explore the universe of human proteins at neXtProt for HMMR: NX_O75330

Explore proteomics data for HMMR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75330

  • HMMR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HMMR Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001136028.1  NP_001136029.1  NP_036616.2  NP_036617.2  

    ENSEMBL proteins: 
     ENSP00000400527   ENSP00000428481   ENSP00000428406   ENSP00000185942   ENSP00000377492  
     ENSP00000402673   ENSP00000351554  
    Reactome Protein details: O75330
    Human Recombinant Protein Products for HMMR: 
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    Novus Biologicals HMMR Protein
    Novus Biologicals HMMR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HMMR 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IEA--

    HMMR for ontologies           About GeneDecksing



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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HMMR 
    Cloud-Clone Corp. CLIAs for HMMR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    1 InterPro protein domain:
     IPR026203 IHABP

    Graphical View of Domain Structure for InterPro Entry O75330

    ProtoNet protein and cluster: O75330


    HMMR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMMR_HUMAN, O75330
    Function: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins,
    including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in
    regulating extracellular-regulated kinase (ERK) activity

         Genatlas biochemistry entry for HMMR:
    hyaluronan-mediated motility receptor,involved in signal transduction via Src tyrosine kinase family,expressed in
    the cytoplasm,nucleus,and cell surface,five isoforms (58,60,64,70,84kDa),regulating cell motility and cell cycle

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005540hyaluronic acid binding IEA--
         
    HMMR for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hmmr):
     reproductive system  tumorigenesis 

    HMMR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hmmrtm1Baa for HMMR

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HMMR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HMMR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HMMR 
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    hsa-miR-3163 hsa-miR-4330 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidHMMR 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): HMMR (NM_012484)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMMR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HMMR About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    2Hyaluronan uptake and degradation
    Hyaluronan uptake and degradation0.71
    Hyaluronan metabolism0.71
    3Integrin Pathway
    FAK1 Signaling0.67
    4Apoptotic Pathways in Synovial Fibroblasts
    Glioma Invasiveness0.64
    5Non-integrin membrane-ECM interactions
    ECM-receptor interaction0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HMMR
        Glioma Invasiveness
    FAK1 Signaling


    5/18        Reactome Pathways for HMMR (see all 18)
        Hyaluronan metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    MPS II - Hunter syndrome


    1         Kegg Pathway  (Kegg details for HMMR):
        ECM-receptor interaction


    HMMR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HMMR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/21 Interacting proteins for HMMR (O753302, 3 ENSP000003774924) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    MAPK3P273613, ENSP000002630254I2D: score=3 STRING: ENSP00000263025
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030212hyaluronan metabolic process TAS--
    GO:0030214hyaluronan catabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    HMMR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HMMR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HMMR

    2 HMDB Compounds for HMMR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronanhyaluronic acid (see all 13)9004-61-9--
    Hyaluronic acidhyaluronic acid 9004-61-9--

    5 Novoseek inferred chemical compound relationships for HMMR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyaluronic acid 84.9 87 8567680 (6), 8314845 (2), 1724753 (2), 19601984 (2) (see all 38)
    chondroitin sulfate 20 1 9601098 (1)
    tyrosine 7.53 5 8750188 (2), 12793201 (1), 1380898 (1)
    pge2 0 1 11943733 (1)
    heparin 0 14 7534313 (7), 9601098 (1)

    Search CenterWatch for drugs/clinical trials and news about HMMR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HMMR gene (4 alternative transcripts): 
    NM_001142556.1  NM_001142557.1  NM_012484.2  NM_012485.2  

    Unigene Cluster for HMMR:

    Hyaluronan-mediated motility receptor (RHAMM)
    Hs.740467  [show with all ESTs]
    Unigene Representative Sequence: NM_001142556
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416990 ENST00000520345 ENST00000522094 ENST00000353866 ENST00000393915(uc003lzh.3 uc003lzf.3 uc003lzg.3 uc011dem.2)
    ENST00000432118 ENST00000521108 ENST00000358715 ENST00000517936
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate HMMR:
    hsa-miR-3163 hsa-miR-4330 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidHMMR 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF032862.1 AK290577.1 AK302975.1 AK303616.1 AK313603.1 AY623426.1 BC017793.1 BC030505.2 
    BC033568.1 BC057235.1 BC070281.1 BC107869.1 BC108904.1 BC108905.1 U29343.1 

    13 DOTS entries:

    DT.91706417  DT.100791432  DT.99969051  DT.91749528  DT.95271259  DT.100714653  DT.75169576  DT.120888710 
    DT.100791427  DT.92019707  DT.92022397  DT.92023184  DT.91789912 

    24/172 AceView cDNA sequences (see all 172):

    BQ000586 BM725946 CR592683 NM_012484 CR601287 BM788751 AI209041 AA909904 
    BQ027031 AA804515 AA831946 AI088336 AF032862 AA262978 NM_012485 BE892436 
    CB132559 AA593010 AU131763 CA443399 AA912764 BM680960 AA553484 AA687269 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HMMR (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19
    SP1:                                -                                                                                                               
    SP2:                                -                                                                                                               
    SP3:                                -     -                                                                                                         
    SP4:        -     -                 -     -                                                                                                         
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for HMMR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HMMR expression in normal human tissues (normalized intensities)      HMMR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTACTCAGC
    HMMR Expression
    About this image


    HMMR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Umbilical cord blood-derived endothelial progenitor cells
             blood vessel   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived endothelial progenitor cells
             Human Umbilical Mesenchymal Stem Cells (HUMSC)   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Human Intestinal Smooth Muscle Cells (HISMC)   
     
     Fibroblast (Endocrine System)    fully expand to see all 2 entries
             Human Prostate Fibroblasts (HPrF)   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium

    See HMMR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HMMR

    SOURCE GeneReport for Unigene cluster: Hs.740467

    UniProtKB/Swiss-Prot: HMMR_HUMAN, O75330
    Tissue specificity: Expressed in breast cancer cell lines and in normal breast tissue

        SABiosciences Expression via Pathway-Focused PCR Array including HMMR: 
              Lung Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HMMR gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmmr1 , 5 hyaluronan mediated motility receptor (RHAMM)1, 5 70.43(n)1
    64.03(a)1
      11 (24.40 cM)5
    153661  NM_013552.21  NP_038580.21 
     407013955 
    chicken
    (Gallus gallus)
    Aves HMMR1 hyaluronan-mediated motility receptor (RHAMM) 61.88(n)
    51.34(a)
      416163  XM_414495.3  XP_414495.3 
    lizard
    (Anolis carolinensis)
    Reptilia HMMR6
    hyaluronan-mediated motility receptor (RHAMM)
    46(a)
    1 ↔ 1
    1(108079424-108111805)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.227202 Xenopus laevis transcribed sequence with weak similarity more 74.32(n)    AW646000.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmmr2 hyaluronan mediated motility receptor 68.28(n)   322012  AY423004.1 


    ENSEMBL Gene Tree for HMMR (if available)
    TreeFam Gene Tree for HMMR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HMMR gene
    1 SIMAP similar gene for HMMR using alignment to 10 protein entries:     HMMR_HUMAN (see all proteins):
    KIF15

    HMMR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/684 SNPs in HMMR are shown (see all 684)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs709970521,2
    C--157992242(-) AGACC-/AG    
       CCT
    /T
    AGCCT
    4 -- int11NA 2
    rs1139030811,2
    C--162892558(+) TGGGC-/AGGCT 
            
    AGGCT
    4 -- int11Minor allele frequency- AGGCT:0.00CSA 2
    rs358999061,2
    C--162895808(+) AGGTT-/CCCCCC 4 -- int10--------
    rs1153187311,2
    F--163114409(+) GGGACC/TCTGTC 4 -- us2k11Minor allele frequency- T:0.03WA 118
    rs2006519091,2
    --163114421(+) AATAA-/ATATATA 4 -- us2k10--------
    rs1125894031,2
    C--163114429(+) TATAT-/ATTTTT 4 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1830154121,2
    --163114577(+) GTCTAC/TACGTA 4 -- us2k10--------
    rs725470771,2
    C--163114646(+) AATTT-/TTAATC 4 -- us2k10--------
    rs58728231,2
    C--163114647(+) ATTTA-/TAATCG 4 -- us2k1 tfbs31Minor allele frequency- T:0.00CSA 2
    rs2992881,2
    C,F,H--163114669(+) CATTGT/GTGAGG 4 -- us2k111Minor allele frequency- G:0.35NS EA NA WA 780

    HapMap Linkage Disequilibrium report for HMMR (162887175 - 162918951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HMMR:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv524084CNV Loss19592680
    nsv519801CNV Loss19592680
    nsv830538CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600936   
    OMIM disorders: 114480  
    20/47 diseases for HMMR (see all 47):    About MalaCards
    nodular basal cell carcinoma    breast cancer susceptibility    chronic graft versus host disease    cystitis
    fibrosarcoma    basal cell carcinoma    b-cell chronic lymphocytic leukemia    stomach cancer
    morquio syndrome b    endocarditis    myeloma    breast cancer
    chronic myeloid leukemia    multiple myeloma    graft versus host disease    oral squamous cell carcinoma
    diffuse large b-cell lymphoma    amyloidosis    transitional cell carcinoma    eclampsia


    HMMR for disorders           About GeneDecksing

    10/16 Novoseek inferred disease relationships for HMMR gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrosarcoma 36 2 8750188 (1), 7541721 (1)
    leukemia hairy cell 35.4 4 7678518 (2), 7529076 (1)
    metastasis 28.6 16 9533523 (3), 18174258 (2), 11029494 (1), 12469144 (1) (see all 10)
    tumors 28.1 29 11029494 (4), 18971636 (2), 9533523 (2), 11716065 (1) (see all 18)
    myeloma 27 2 15705883 (1), 7529076 (1)
    myxoma 25.3 2 1710472 (1), 2035257 (1)
    cancer 17.7 13 18174258 (2), 11029494 (1), 12469144 (1), 15705883 (1) (see all 9)
    leukemia 16.3 1 19724689 (1)
    breast carcinoma 8.39 3 8750188 (1), 9601098 (1), 9533523 (1)
    primary tumor 3.25 3 9533523 (3)

    Genetic Association Database (GAD): HMMR
    Human Genome Epidemiology (HuGE) Navigator: HMMR (2 documents)

    Export disorders for HMMR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HMMR gene, integrated from 9 sources (see all 171):
    (articles sorted by number of sources associating them with HMMR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells. (PubMed id 9601098)1, 2, 9 Assmann V.... Hart I.R. (1998)
    2. Hyaluronan-mediated motility receptor gene single nucleotide polymorphisms and risk of breast cancer. (PubMed id 19064580)1, 4, 9 Kalmyrzaev B....Dunning A.M. (2008)
    3. The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains. (PubMed id 8890751)1, 2 Wang C.... Turley E.A. (1996)
    4. RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53. (PubMed id 18971636)1, 9 Sohr S. and Engeland K. (2008)
    5. Regulated expression of a receptor for hyaluronan-mediated motility on human thymocytes and T cells. (PubMed id 7683315)1, 9 Pilarski L.M....Turley E.A. (1993)
    6. Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas. (PubMed id 19424574)1, 9 Shigeishi H....Kamata N. (2009)
    7. The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. (PubMed id 17392272)1, 9 Hamilton S.R....Turley E.A. (2007)
    8. Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity. (PubMed id 15705883)1, 9 Maxwell C.A....Reiman T. (2005)
    9. RHAMM (CD168) is overexpressed at the protein level a nd may constitute an immunogenic antigen in advanced prostate cancer disease. (PubMed id 19724689)1, 9 Gust K.M....Ringhoffer M. (2009)
    10. The human and mouse receptors for hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11. (PubMed id 8595891)1, 9 Spicer A.P....McDonald J.A. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3161 HGNC: 5012 AceView: HMMR Ensembl:ENSG00000072571 euGenes: HUgn3161
    ECgene: HMMR Kegg: 3161 H-InvDB: HMMR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HMMR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HMMR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HMMR gene:
    Search GeneIP for patents involving HMMR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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