HMMR Gene
protein-coding GIFtS: 60
GCID: GC05P162887
|
|
hyaluronan-mediated motility receptor (RHAMM)
| |
Aliases
for HMMR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hyaluronan-Mediated Motility Receptor (RHAMM)1 2 | | Receptor For Hyaluronan-Mediated Motility2 3 | | RHAMM1 2 3 | | IHABP2 3 | | CD1681 2 | | Hyaluronan Mediated Motility Receptor2 | | Intracellular Hyaluronic Acid-Binding Protein2 3 | | CD168 Antigen3 |
Export aliases for HMMR gene to outside databasesPrevious GC identifers: GC05P163090 GC05P163480 GC05P162822 GC05P162868 GC05P162820 GC05P157987 |
Summaries
for HMMR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HMMR:
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with otherproteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer.Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. (provided byRefSeq, Dec 2008)
UniProtKB/Swiss-Prot: HMMR_HUMAN, O75330Function: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins,including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and inregulating extracellular-regulated kinase (ERK) activity
Gene Wiki entry for HMMR (Hyaluronan-mediated motility receptor)
|
Genomic Views
for HMMR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HMMR gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 POU2F2C POU2F1 POU2F1a c-Myb POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for HMMR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMMR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q33.2-qter Ensembl cytogenetic band: 5q34 HGNC cytogenetic band: 5q33.2-qterHMMR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P162887: view genomic region
(about GC identifiers)
Start:
|
162,887,175 bp from pter |
End:
|
162,918,951 bp from pter |
Size:
|
31,777 bases |
Orientation:
|
plus strand |
|
Proteins
for HMMR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HMMR_HUMAN, O75330 (See
protein sequence)Recommended Name: Hyaluronan mediated motility receptor Size: 724 amino acids; 84100 Da
Subunit: Subunit of the HARC complex
Subcellular location: Cell surface. Cytoplasm (By similarity)
Secondary accessions: A8K3G2 B4E114 D3DQK9 D3DQL0 E9PCS0 Q32N02 Q92767Alternative splicing: 4 isoforms: O75330-1 O75330-2 O75330-3 O75330-4 Explore the universe of human proteins at neXtProt for HMMR: NX_O75330
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75330
HMMR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001136028.1 NP_001136029.1 NP_036616.2 NP_036617.2
ENSEMBL proteins: ENSP00000400527 ENSP00000428481 ENSP00000428406 ENSP00000185942 ENSP00000377492 ENSP00000402673 ENSP00000351554 Reactome Protein details: O75330
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
HMMR for ontologies About GeneDecksing
HMMR Antibody Products:
Assay Products for HMMR: |
Protein
Domains /
Families
for HMMR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HMMR for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O75330ProtoNet protein and cluster: O75330 |
Function
for HMMR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HMMR_HUMAN, O75330Function: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins,including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and inregulating extracellular-regulated kinase (ERK) activity Genatlas biochemistry entry for HMMR:hyaluronan-mediated motility receptor,involved in signal transduction via Src tyrosine kinase family,expressed in thecytoplasm,nucleus,and cell surface,five isoforms (58,60,64,70,84kDa),regulating cell motility and cell cycle
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMMR (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMMR (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): HMMR (NM_012484) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMMR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMMR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMMR |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005540 | hyaluronic acid binding |
IEA | -- |
HMMR for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Hmmrtm1Baa for HMMR
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Hmmr):
HMMR for phenotypes About GeneDecksing
|
Pathways & Interactions
for HMMR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | MPS IIIC - Sanfilippo syndrome C | | | 2 | Hyaluronan uptake and degradation | | | 3 | Disease | | | 4 | Metabolism | | | 5 | ECM-receptor interaction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HMMR
5/19 
Reactome Pathways for HMMR (see all 19)
1 
Kegg Pathway (Kegg details for HMMR):
HMMR for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HMMR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/21 Interacting proteins for HMMR (O753302, 3 ENSP000003774924) via UniProtKB, MINT, STRING, and/or I2D (see all 21)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
TAS | -- | | GO:0030203 | glycosaminoglycan metabolic process |
TAS | -- | | GO:0030212 | hyaluronan metabolic process |
TAS | -- | | GO:0030214 | hyaluronan catabolic process |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
HMMR for ontologies About GeneDecksing
|
Drugs & Compounds
for HMMR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HMMR for compounds About GeneDecksing
 Browse Tocris compounds for HMMR
2 HMDB Compounds for HMMR About this table
5 Novoseek chemical compound relationships for HMMR gene About this table
Search CenterWatch for drugs/clinical trials and news about HMMR
|
Transcripts
for HMMR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HMMR gene (4 alternative transcripts): NM_001142556.1 NM_001142557.1 NM_012484.2 NM_012485.2 Unigene Cluster for HMMR: Hyaluronan-mediated motility receptor (RHAMM) Hs.740467 [show with all ESTs]Unigene Representative Sequence: NM_0011425569 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000416990 ENST00000520345 ENST00000522094 ENST00000353866 ENST00000393915(uc003lzh.3 uc003lzf.3 uc003lzg.3 uc011dem.2)
ENST00000432118 ENST00000521108 ENST00000358715 ENST00000517936
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMMR (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMMR (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): HMMR (NM_012484) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMMR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMMR |
Additional cDNA sequence: AF032862.1 AK290577.1 AK302975.1 AK303616.1 AK313603.1 AY623426.1 BC017793.1 BC030505.2 BC033568.1 BC057235.1 BC070281.1 BC107869.1 BC108904.1 BC108905.1 U29343.1 13 DOTS entries: DT.91706417 DT.100791432 DT.99969051 DT.91749528 DT.95271259 DT.100714653 DT.75169576 DT.120888710 DT.100791427 DT.92019707 DT.92022397 DT.92023184 DT.91789912 24/172 AceView cDNA sequences (see all 172): BM788751 BE327167 AW057729 BM725946 BM849217 CR592683 CA443399 NM_012485 AA593010 AU131763 BQ000586 BM680960 AI088336 AF032862 BM764295 BE042983 AA831946 AA262978 BE892436 CB132559 BQ027031 BM772368 BQ010466 AI209041
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HMMR (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HMMR
|
Expression
for HMMR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HMMR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTACTCAGC
About this image
See HMMR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HMMR
SOURCE GeneReport for Unigene cluster: Hs.740467
UniProtKB/Swiss-Prot: HMMR_HUMAN, O75330Tissue specificity: Expressed in breast cancer cell lines and in normal breast tissue
SABiosciences Expression via Pathway-Focused PCR Array including HMMR:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMMR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HMMR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMMR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMMR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMMR |
Orthologs
for HMMR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HMMR gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Hmmr1 , 5 |
hyaluronan mediated motility receptor (RHAMM)1, 5 |
70.43(n)1
64.03(a)1 |
|
11 (24.40 cM)5
153661 NM_013552.21 NP_038580.21
407013955 |
chicken
(Gallus gallus) |
Aves |
HMMR1 |
hyaluronan-mediated motility receptor (RHAMM) |
61.88(n)
51.34(a) |
|
416163 XM_414495.3 XP_414495.3 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.227202 |
Xenopus laevis transcribed sequence with weak similarity more |
74.32(n) |
|
AW646000.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
hmmr2 |
hyaluronan mediated motility receptor |
68.28(n) |
|
322012 AY423004.1 |
ENSEMBL Gene Tree for HMMR (if available)
TreeFam Gene Tree for HMMR (if available) |
Paralogs
for HMMR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HMMR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HMMR (162887175 - 162918951 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for HMMR
2 CNVs: 93332 51611
1 Indel: 40812 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMMR |
|
Disorders
/ Diseases
for HMMR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HMMR for disorders About GeneDecksing
OMIM gene information: 600936
OMIM disorders: 114480
20/48  diseases for HMMR (see all 48): About MalaCardsbreast cancer diffuse large b-cell lymphoma graft versus host disease b-cell lymphomas
pre-eclampsia nodular basal cell carcinoma basal cell carcinoma breast cancer susceptibility
oral squamous cell carcinoma myxoma squamous cell carcinoma myeloid leukemia
transitional cell carcinoma acute lymphoblastic leukemia chronic lymphocytic leukemia acute myeloid leukemia
chronic myeloid leukemia lymphoblastic leukemia lymphocytic leukemia fibrosarcoma
10/16 Novoseek disease relationships for HMMR gene (see all 16) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fibrosarcoma |
36 |
2 |
8750188 (1), 7541721 (1) |
| leukemia hairy cell |
35.4 |
4 |
7678518 (2), 7529076 (1) |
| metastasis |
28.6 |
16 |
9533523 (3), 18174258 (2), 11029494 (1), 12469144 (1) (see all 10) |
| tumors |
28.1 |
29 |
11029494 (4), 18971636 (2), 9533523 (2), 11716065 (1) (see all 18) |
| myeloma |
27 |
2 |
15705883 (1), 7529076 (1) |
| myxoma |
25.3 |
2 |
1710472 (1), 2035257 (1) |
| cancer |
17.7 |
13 |
18174258 (2), 11029494 (1), 12469144 (1), 15705883 (1) (see all 9) |
| leukemia |
16.3 |
1 |
19724689 (1) |
| breast carcinoma |
8.39 |
3 |
8750188 (1), 9601098 (1), 9533523 (1) |
| primary tumor |
3.25 |
3 |
9533523 (3) |
Human Genome Epidemiology (HuGE) Navigator: HMMR (2 documents)
Export disorders for HMMR gene to outside databases
|
Publications
for HMMR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HMMR gene, integrated from 9 sources (see all 165):
(articles sorted by number of sources associating them with HMMR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells. (PubMed id 9601098)1, 2, 9 Assmann V.... Hart I.R. (1998)
- The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains. (PubMed id 8890751)1, 2 Wang C.... Turley E.A. (1996)
- RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53. (PubMed id 18971636)1, 9 Sohr S. and Engeland K. (2008)
- Regulated expression of a receptor for hyaluronan-mediated motility on human thymocytes and T cells. (PubMed id 7683315)1, 9 Pilarski L.M....Turley E.A. (1993)
- Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas. (PubMed id 19424574)1, 9 Shigeishi H....Kamata N. (2009)
- The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. (PubMed id 17392272)1, 9 Hamilton S.R....Turley E.A. (2007)
- Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity. (PubMed id 15705883)1, 9 Maxwell C.A....Reiman T. (2005)
- RHAMM (CD168) is overexpressed at the protein level a nd may constitute an immunogenic antigen in advanced prostate cancer disease. (PubMed id 19724689)1, 9 Gust K.M....Ringhoffer M. (2009)
- The human and mouse receptors for hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11. (PubMed id 8595891)1, 9 Spicer A.P....McDonald J.A. (1995)
- The candidate immunotherapeutical target, the receptor for hyaluronic acid-mediated motility, is associated with proliferation and shows prognostic value in B-cell chronic lymphocytic leukemia. (PubMed id 19092852)1, 9 Giannopoulos K....Schmitt M. (2009)
|
External Searches for HMMR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HMMR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HMMR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HMMR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HMMR gene:
Search GeneIP for patents involving HMMR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HMMR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for HMMR | | OriGene shRNA RFP for HMMR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMMR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMMR | | | OriGene Protein Over-expression Lysate for HMMR | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HMMR | | OriGene 3'-UTR Clone for HMMR | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMMR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMMR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HMMR | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HMMR | | OriGene Custom Protein Services for HMMR | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HMMR | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMMR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMMR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMMR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMMR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMMR |
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| | | | Search Tocris compounds for HMMR |
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 | | | HMMR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMMR |
|  |  |  | | | | ThermoFisher Antibodies for HMMR |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMMR |
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