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Aliases for HMHB1 Gene

Aliases for HMHB1 Gene

  • Histocompatibility (Minor) HB-1 2 3
  • HLA-HB1 3 6
  • Minor Histocompatibility Antigen HB-1 3
  • Minor Histocompatibility Protein HB-1 3
  • HB-1Y 3
  • Hb-1 3

External Ids for HMHB1 Gene

Previous GeneCards Identifiers for HMHB1 Gene

  • GC05P143172
  • GC05P138338

Summaries for HMHB1 Gene

Entrez Gene Summary for HMHB1 Gene

  • This gene encodes one of the minor histocompatibility antigens, which play an important role in the induction of cytotoxic T lymphocyte (CTL) reactivity against leukemia after human histocompatibility leukocyte antigen (HLA)-identical allogeneic bone marrow transplantation (BMT). This gene is only expressed in B cell acute lymphoblastic leukemia cells and Epstein-Barr virus-transformed B cells. The translation of this mRNA initiates at a non-AUG (CUG) codon. [provided by RefSeq, Jul 2008]

GeneCards Summary for HMHB1 Gene

HMHB1 (Histocompatibility (Minor) HB-1) is a Protein Coding gene. Diseases associated with HMHB1 include lymphoblastic leukemia.

UniProtKB/Swiss-Prot for HMHB1 Gene

  • Precursor of the histocomplatibility antigen HB-1. More generally, minor histocomplatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocomplatibility antigen in HLA-matched sibling marrow transplants. HB-1 is presented on the cell surface by MHC class I HLA-B44. This complex specifically elicits donor-cytotoxic T lymphocyte (CTL) reactivity in B-cell acute lymphoblastic leukemia (B-ALL) after treatment by HLA-identical allogenic bone marrow transplantation (BMT). It induces cell recognition and lysis by CTL. However, HB-1 restricted expression in B-ALL cells and not in normal tissues may allow a specific CTL reactivity against B-ALL without the risk of evoking graft-versus-host disease.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMHB1 Gene

Genomics for HMHB1 Gene

Regulatory Elements for HMHB1 Gene

Genomic Location for HMHB1 Gene

Start:
143,812,161 bp from pter
End:
143,820,719 bp from pter
Size:
8,559 bases
Orientation:
Plus strand

Genomic View for HMHB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMHB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMHB1 Gene

Proteins for HMHB1 Gene

  • Protein details for HMHB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O97980-HMHB1_HUMAN
    Recommended name:
    Minor histocompatibility protein HB-1
    Protein Accession:
    O97980
    Secondary Accessions:
    • Q9MY25

    Protein attributes for HMHB1 Gene

    Size:
    41 amino acids
    Molecular mass:
    4965 Da
    Quaternary structure:
    • HB-1 forms a complex with MHC class I HLA-B44

neXtProt entry for HMHB1 Gene

Proteomics data for HMHB1 Gene at MOPED

Post-translational modifications for HMHB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMHB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HMHB1 Gene

Domains for HMHB1 Gene

Protein Domains for HMHB1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for HMHB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HMHB1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HMHB1 Gene

Function for HMHB1 Gene

Molecular function for HMHB1 Gene

UniProtKB/Swiss-Prot Function: Precursor of the histocomplatibility antigen HB-1. More generally, minor histocomplatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocomplatibility antigen in HLA-matched sibling marrow transplants. HB-1 is presented on the cell surface by MHC class I HLA-B44. This complex specifically elicits donor-cytotoxic T lymphocyte (CTL) reactivity in B-cell acute lymphoblastic leukemia (B-ALL) after treatment by HLA-identical allogenic bone marrow transplantation (BMT). It induces cell recognition and lysis by CTL. However, HB-1 restricted expression in B-ALL cells and not in normal tissues may allow a specific CTL reactivity against B-ALL without the risk of evoking graft-versus-host disease.

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HMHB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HMHB1 Gene

Localization for HMHB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMHB1 Gene COMPARTMENTS Subcellular localization image for HMHB1 gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HMHB1 Gene

Pathways for HMHB1 Gene

SuperPathways for HMHB1 Gene

No Data Available

Interacting Proteins for HMHB1 Gene

Gene Ontology (GO) - Biological Process for HMHB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with HMHB1: view

No data available for Pathways by source for HMHB1 Gene

Transcripts for HMHB1 Gene

mRNA/cDNA for HMHB1 Gene

(8) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HMHB1 Gene

Histocompatibility (minor) HB-1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HMHB1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMHB1 Gene

No ASD Table

Relevant External Links for HMHB1 Gene

GeneLoc Exon Structure for
HMHB1
ECgene alternative splicing isoforms for
HMHB1

Expression for HMHB1 Gene

mRNA expression in normal human tissues for HMHB1 Gene

mRNA differential expression in normal tissues according to GTEx for HMHB1 Gene

This gene is overexpressed in Testis (10.9).

SOURCE GeneReport for Unigene cluster for HMHB1 Gene Hs.158320

mRNA Expression by UniProt/SwissProt for HMHB1 Gene

O97980-HMHB1_HUMAN
Tissue specificity: Expressed in acute lymphoblastic leukemia B-cells and Epstein-Barr virus-transformed B-cells.
genes like me logo Genes that share expressions with HMHB1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for HMHB1 Gene

Orthologs for HMHB1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for HMHB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMHB1 36
  • 100 (a)
OneToOne
Species with no ortholog for HMHB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HMHB1 Gene

ENSEMBL:
Gene Tree for HMHB1 (if available)
TreeFam:
Gene Tree for HMHB1 (if available)

Paralogs for HMHB1 Gene

No data available for Paralogs for HMHB1 Gene

Variants for HMHB1 Gene

Sequence variations from dbSNP and Humsavar for HMHB1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs149614 -- 143,810,837(-) atagt(G/T)cctca upstream-variant-2KB
rs161556 -- 143,820,422(+) AAATA(A/G)AAAAT intron-variant
rs161557 - 143,820,488(+) CTCTG(C/T)ATGTT reference, missense
rs161569 -- 143,810,205(+) cacag(A/G)aagtt upstream-variant-2KB
rs161570 -- 143,811,255(+) TAATA(C/T)ATTTT upstream-variant-2KB

Relevant External Links for HMHB1 Gene

HapMap Linkage Disequilibrium report
HMHB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HMHB1 Gene

Disorders for HMHB1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HMHB1 Gene including...

Search for HMHB1 Gene in MalaCards »

Relevant External Links for HMHB1

Genetic Association Database (GAD)
HMHB1
Human Genome Epidemiology (HuGE) Navigator
HMHB1
genes like me logo Genes that share disorders with HMHB1: view

No data available for UniProtKB/Swiss-Prot for HMHB1 Gene

Publications for HMHB1 Gene

  1. A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia. (PMID: 9892612) Dolstra H. … van de Wiel-van Kemenade E. (J. Exp. Med. 1999) 2 3 4 23
  2. Role of minor histocompatibility antigens in renal transplantation. (PMID: 18093280) Heinold A. … Tran T.H. (Am. J. Transplant. 2008) 3 23 48
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  4. Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation. (PMID: 20353833) Larsen M.E. … Vindelov L. (Biol. Blood Marrow Transplant. 2010) 3 48
  5. Improved genotyping of the human minor histocompatibility antigen HB-1 by polymerase chain reaction with sequence-specific primers using a complementary oligonucleotide. (PMID: 20718936) Park M.J. … Kim T.G. (Tissue Antigens 2010) 3

Products for HMHB1 Gene

Sources for HMHB1 Gene

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