Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HMHA1 Gene

protein-coding   GIFtS: 58
GCID: GC19P001066

Histocompatibility (Minor) HA-1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Histocompatibility (Minor) HA-11 2     HA-12
HLA-HA12 5     Minor Histocompatibility Antigen HA-12
KIAA02233 5     Minor Histocompatibility Protein HA-12
ARHGAP452     

External Ids:    HGNC: 171021   Entrez Gene: 235262   Ensembl: ENSG000001804487   OMIM: 6011555   UniProtKB: Q926193   

Export aliases for HMHA1 gene to outside databases

Previous GC identifers: GC19P001019 GC19P000841


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for HMHA1 Gene:
HMHA1 (histocompatibility (minor) HA-1) is a protein-coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP29.

UniProtKB/Swiss-Prot: HMHA1_HUMAN, Q92619
Function: GTPase activator for the Rho-type GTPases (Potential)
Function: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens
(mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after
recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are
cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II
molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft
rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical
sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor
histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1
which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after
HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A
alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic
malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL

Gene Wiki entry for HMHA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HMHA1 gene promoter:
         Sox5   Tal-1   SREBP-1c   MIF-1   Tal-1beta   E47   SREBP-1b   AREB6   SREBP-1a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHMHA1 promoter sequence
   Search Chromatin IP Primers for HMHA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMHA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

HMHA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMHA1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001066:  view genomic region     (about GC identifiers)

Start:
1,065,922 bp from pter      End:
1,086,627 bp from pter
Size:
20,706 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HMHA1_HUMAN, Q92619 (See protein sequence)
Recommended Name: Minor histocompatibility protein HA-1  
Size: 1136 amino acids; 124614 Da
Subunit: HA-1 forms a complex with MHC class I HLA-A*0201
Miscellaneous: Infusion of lymphocyte from mHag HA-1-negative donors results in a durable remission in mHag
HA-1-positive patients with leukemia or multiple myeloma
Sequence caution: Sequence=BAA13212.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for HMHA1:
3D25 (3D)    
Secondary accessions: B4DTS4 F6QP70 Q6P189 Q7LE26 Q86WS1 Q8HX84 Q9GJN9 Q9GJP0 Q9GJP1 Q9MY24
Alternative splicing: 2 isoforms:  Q92619-1   Q92619-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HMHA1: NX_Q92619

Explore proteomics data for HMHA1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HMHA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001245257.1  NP_001269263.1  NP_001269264.1  NP_036424.2  

    ENSEMBL proteins: 
     ENSP00000439601   ENSP00000467741   ENSP00000316772   ENSP00000466365   ENSP00000466401  
     ENSP00000468615   ENSP00000438979   ENSP00000467525   ENSP00000468607   ENSP00000445109  
    Reactome Protein details: Q92619

    HMHA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HMHA1
    OriGene Protein Over-expression Lysate for HMHA1
    OriGene MassSpec for HMHA1
    OriGene Custom Protein Services for HMHA1
    GenScript Custom Purified and Recombinant Proteins Services for HMHA1
    Novus Biologicals HMHA1 Protein
    Novus Biologicals HMHA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HMHA1

     
    Search eBioscience for Proteins for HMHA1 

     
    antibodies-online proteins for HMHA1 (2 products) 

     
    antibodies-online peptides for HMHA1

    HMHA1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HMHA1
    Novus Biologicals HMHA1 Antibodies
    Abcam antibodies for HMHA1
    Cloud-Clone Corp. Antibodies for HMHA1
    Search ThermoFisher Antibodies for HMHA1
    antibodies-online antibodies for HMHA1 (22 products) 

    HMHA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HMHA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HMHA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HMHA1
    Cloud-Clone Corp. CLIAs for HMHA1
    Search eBioscience for ELISAs for HMHA1 
    antibodies-online kits for HMHA1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    4 InterPro protein domains:
     IPR001060 FCH_dom
     IPR008936 Rho_GTPase_activation_prot
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q92619

    ProtoNet protein and cluster: Q92619

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: HMHA1_HUMAN, Q92619
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 Rho-GAP domain


    Find genes that share domains with HMHA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMHA1_HUMAN, Q92619
    Function: GTPase activator for the Rho-type GTPases (Potential)
    Function: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens
    (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after
    recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are
    cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II
    molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft
    rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical
    sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor
    histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1
    which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after
    HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A
    alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic
    malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with HMHA1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HMHA1:
     Increased G2M DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HMHA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HMHA1:
    hsa-mir-335-5p (MIRT018785)

    Block miRNA regulation of human, mouse, rat HMHA1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HMHA1
    SwitchGear 3'UTR luciferase reporter plasmidHMHA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HMHA1
    Predesigned siRNA for gene silencing in human, mouse, rat HMHA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HMHA1

    Clone
    Products:
         
    OriGene clones in human, mouse for HMHA1 (see all 6)
    OriGene ORF clones in mouse, rat for HMHA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HMHA1 (NM_012292)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMHA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMHA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HMHA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HMHA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMHA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    golgi apparatus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with HMHA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HMHA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with HMHA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for HMHA1
        Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HMHA1
    Interactions:

        Search GeneGlobe Interaction Network for HMHA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HMHA1 (ENSP000003167724) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF38ENSP000002651544STRING: ENSP00000416125 STRING: ENSP00000265154
    ARHGAP4ENSP000002037864STRING: ENSP00000203786
    ARHGDIBENSP000002289454STRING: ENSP00000228945
    ARHGEF11ENSP000003571774STRING: ENSP00000357177
    ARHGEF18ENSP000003529954STRING: ENSP00000352995
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0035556intracellular signal transduction ----
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with HMHA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HMHA1

    Selected HMDB Compounds for HMHA1 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HMHA1 gene (4 alternative transcripts): 
    NM_001258328.2  NM_001282334.1  NM_001282335.1  NM_012292.4  

    Unigene Cluster for HMHA1:

    Histocompatibility (minor) HA-1
    Hs.465521  [show with all ESTs]
    Unigene Representative Sequence: BC065223
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539243 ENST00000587186 ENST00000313093(uc010xgd.1 uc002lqz.1 uc010xge.1 uc002lra.1)
    ENST00000587602 ENST00000591293 ENST00000590214 ENST00000586866 ENST00000543365(uc002lrb.1 uc002lrc.1)
    ENST00000592335 ENST00000586033 ENST00000590577 ENST00000586937 ENST00000590512
    ENST00000586378 ENST00000592297 ENST00000591169 ENST00000536472
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HMHA1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HMHA1
    SwitchGear 3'UTR luciferase reporter plasmidHMHA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HMHA1
    Predesigned siRNA for gene silencing in human, mouse, rat HMHA1
    Clone
    Products:
         
    OriGene clones in human, mouse for HMHA1 (see all 6)
    OriGene ORF clones in mouse, rat for HMHA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HMHA1 (NM_012292)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMHA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMHA1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HMHA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HMHA1
      QuantiTect SYBR Green Assays in human, mouse, rat HMHA1
      QuantiFast Probe-based Assays in human, mouse, rat HMHA1

    Additional mRNA sequence: 

    AK122776.1 AK128097.1 AK300341.1 AK304271.1 BC035564.1 BC048129.1 BC065223.1 D86976.1 
    NR_047652.1 

    19 DOTS entries:

    DT.101983553  DT.95136574  DT.97772339  DT.442145  DT.101983552  DT.99991844  DT.100741848  DT.100817986 
    DT.121441251  DT.95136591  DT.92430507  DT.100817992  DT.121441246  DT.121441517  DT.121441524  DT.121441602 
    DT.95136573  DT.95298816  DT.40221910 

    Selected AceView cDNA sequences (see all 193):

    BG388120 CR603358 BM714648 BM807016 BQ229701 BC048129 AI674929 BQ049726 
    BQ878430 BM922661 BX337482 AI270222 AI457902 BQ705987 BE208751 BQ682808 
    D86976 CR608309 BQ689919 BU616439 AW793644 BQ030276 AL041721 BU838153 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HMHA1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
    SP1:        -           -     -                                                           -                                                     -               
    SP2:                    -     -                                                           -                                                     -               
    SP3:                          -                                                           -                                                     -               
    SP4:                                                                                                                                            -               
    SP5:                                                                                                                                            -               

    ExUns: 23 ^ 24a · 24b · 24c · 24d ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b · 27c
    SP1:  -     -                                                               
    SP2:  -     -                                                               
    SP3:  -     -                                                               
    SP4:  -     -                                                               
    SP5:                                                                        


    ECgene alternative splicing isoforms for HMHA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HMHA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCTCCGTG
    HMHA1 Expression
    About this image


    HMHA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Brain (Nervous System)
             Lateral Ventricle
     
     Spleen (Hematopoietic System)
    HMHA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMHA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465521

    UniProtKB/Swiss-Prot: HMHA1_HUMAN, Q92619
    Tissue specificity: Expressed on cells of the hematopoietic lineage. Detected in dendritic cells and epidermal
    Langerhans cells. Expressed in peripheral blood mononuclear cells, in all leukemia/lymphoma cell lines. Detected
    also in some solid tumors and tissues such as cancerous and non-cancerous tissue

        Custom PCR Arrays for HMHA1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HMHA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HMHA1
    QuantiTect SYBR Green Assays in human, mouse, rat HMHA1
    QuantiFast Probe-based Assays in human, mouse, rat HMHA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMHA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HMHA1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmha11 , 5 histocompatibility (minor) HA-11, 5 80.26(n)1
    83.56(a)1
      10 (39.72 cM)5
    707191  NM_001142701.11  NP_001136173.11 
     800166535 
    chicken
    (Gallus gallus)
    Aves HMHA11 histocompatibility (minor) HA-1 74.2(n)
    72.43(a)
      420102  NM_001030937.1  NP_001026108.1 
    lizard
    (Anolis carolinensis)
    Reptilia HMHA16
    histocompatibility (minor) HA-1
    64(a)
    1 ↔ 1
    GL344210.1(29132-62567)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.113972 Transcribed sequence with weak similarity to protein refNP_004806.1 (H.sapiens) PTPL1-associated RhoGAP 1 [Homo sapiens] less 74.11(n)    BX739199.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmha1b1 histocompatibility (minor) HA-1 b 65.02(n)
    63.05(a)
      555849  XM_678493.5  XP_683585.5 
    worm
    (Caenorhabditis elegans)
    Secernentea spv-16
    Protein TAG-341, isoform a
    21(a)
    1 → many
    II(7912766-7928655) WBGene00014051
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RGA16
    RGA26
    GTPase-activating protein for the polarity-establi...
    GTPase-activating protein for the polarity-establi...
    15(a)
    15(a)
    many ↔ many
    many ↔ many
    XV(561170-564193) YOR127W
    IV(1230167-1233196) YDR379W


    ENSEMBL Gene Tree for HMHA1 (if available)
    TreeFam Gene Tree for HMHA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HMHA1 gene
    ARHGAP292  ARHGAP192  GMIP2  ARHGAP19-SLIT12  
    11 SIMAP similar genes for HMHA1 using alignment to 10 protein entries:     HMHA1_HUMAN (see all proteins):
    ARHGAP24    OPHN1    ARHGAP21    CHN2    ARHGAP31    ARHGAP29
    ARHGAP12    ARHGAP23    CHN1    GMIP    ABR

    Find genes that share paralogs with HMHA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    HMHA1_HUMAN, Q92619: The HA-1H allele is presented on the cell surface and recognized by CTL, whereas the HA-1R allele is
    poorly represented by HLA-A and non-immunogenic, although HA-1R allelic frequency is the highest


    Selected SNPs for HMHA1 (see all 645)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1997454121,2
    C--1004913(+) AGTGAC/GCCGGT 1 -- us2k10--------
    rs1118311771,2
    C--1004916(+) GAGCCG/AGTGCC 1 -- us2k12Minor allele frequency- A:0.10CSA WA 120
    rs41479381,2
    C,F--1066256(+) GGGAGA/GGGGGA 2 -- us2k1 int18Minor allele frequency- G:0.39NA WA CSA EA 368
    rs41479391,2
    C,F,H--1066257(+) GGAGGG/AGGGAG 2 -- us2k1 int1 tfbs3 trp34Minor allele frequency- A:0.05NA CSA EA 243
    rs1476809031,2
    --1066328(+) CAGATA/GCCCCA 2 -- us2k1 int10--------
    rs1422160671,2
    --1066442(+) GCGGGA/GCTGGG 2 -- us2k1 int10--------
    rs1459338991,2
    --1066456(+) CTTAGC/TTAAGG 2 -- us2k1 int10--------
    rs1923137071,2
    --1066488(+) ATGGCC/TCACAG 2 -- us2k1 int10--------
    rs1121310721,2
    C--1066626(+) ACCCAGACGGACA
    GGGCCC
    /-
    GGTAA
    2 -- us2k1 int11Minor allele frequency- -:0.50CSA 2
    rs41479401,2
    C,F,H--1066738(+) CTTCAC/TGGGGC 2 -- us2k1 int116Minor allele frequency- T:0.28NS EA NA WA 2048

    HapMap Linkage Disequilibrium report for HMHA1 (1065922 - 1086627 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HMHA1 (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470102CNV Loss18288195
    dgv3579n71CNV Loss21882294
    nsv910292CNV Loss21882294
    nsv910411CNV Loss21882294
    dgv3555n71CNV Loss21882294
    dgv3574n71CNV Loss21882294
    dgv3552n71CNV Loss21882294
    dgv3575n71CNV Loss21882294
    nsv910401CNV Loss21882294
    nsv910310CNV Loss21882294

    Human Gene Mutation Database (HGMD): HMHA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HMHA1
    DNA2.0 Custom Variant and Variant Library Synthesis for HMHA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601155    OMIM disorders: --


    Find genes that share disorders with HMHA1           About GenesLikeMe

    9 Novoseek inferred disease relationships for HMHA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    graft-versus-host disease 81.5 5 11144294 (1), 16707472 (1), 10703604 (1), 15350465 (1) (see all 5)
    graft-versus-tumor 71.2 1 16399573 (1)
    acute graft-versus-host disease 70.7 5 10515896 (2), 11564088 (2), 9820595 (1)
    hematologic malignancies 47.3 3 16399573 (2), 12601144 (1)
    solid tumor 41.7 9 19096014 (3), 11965046 (3), 12804533 (1), 16399573 (1)
    leukemia 40.6 8 11965046 (3), 17641837 (1), 12601144 (1), 14502255 (1) (see all 5)
    necrosis 0 1 12438965 (1)
    tumors 0 4 19096014 (2), 12438965 (1), 11965046 (1)
    cancer 0 5 19096014 (2), 12163564 (1), 11965046 (1), 16399573 (1)

    Genetic Association Database (GAD): HMHA1
    Human Genome Epidemiology (HuGE) Navigator: HMHA1 (7 documents)

    Export disorders for HMHA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HMHA1 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with HMHA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1996)
    2. Expression of minor histocompatibility antigen, HA-1, in solid tumor cells. (PubMed id 11965046)1, 2, 9 Fujii N.... Harada M. (Transplantation 2002)
    3. Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA). (PubMed id 10958358)1, 2, 9 Arostegui J.I.... Granena A. (Tissue Antigens 2000)
    4. The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism. (PubMed id 9461441)1, 2, 9 den Haan J.M.... Goulmy E. (Science 1998)
    5. Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary SjAPgren's syndrome. (PubMed id 15593299)1, 4, 9 Harangi M....Schmitz G. (Eur. J. Immunol. 2005)
    6. Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene. (PubMed id 11095984)1, 2, 9 Kaminski W.E.... Schmitz G. (Biochem. Biophys. Res. Commun. 2000)
    7. Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR. (PubMed id 9820596)1, 3, 9 Wilke M....Goulmy E. (Tissue Antigens 1998)
    8. Role of minor histocompatibility antigens in renal transplantation. (PubMed id 18093280)1, 4, 9 Heinold A....Tran T.H. (Am. J. Transplant. 2008)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Role of non-HLA genetic polymorphisms in graft-versus-host disease after haematopoietic stem cell transplantation. (PubMed id 16984283)1, 4 Bertinetto F.E....Amoroso A. (Int. J. Immunogenet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23526 HGNC: 17102 AceView: HA-1 Ensembl:ENSG00000180448 euGenes: HUgn23526
    ECgene: HMHA1 H-InvDB: HMHA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0223

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HMHA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HMHA1 gene:
    Search GeneIP for patents involving HMHA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HMHA1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for HMHA1  
     OriGene MassSpec for HMHA1   OriGene clones in human, mouse for HMHA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for HMHA1   OriGene Purified Protein for HMHA1  
     OriGene ORF clones in mouse, rat for HMHA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HMHA1   OriGene Custom Protein Services for HMHA1  

     
     
     Block miRNA regulation of human, mouse, rat HMHA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HMHA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMHA1 Predesigned siRNA for gene silencing in human, mouse, rat HMHA1
     QuantiFast Probe-based Assays in human, mouse, rat HMHA1 QuantiTect SYBR Green Assays in human, mouse, rat HMHA1
     Custom PCR Arrays for HMHA1 Search Chromatin IP Primers for HMHA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HMHA1  Search GeneGlobe Interaction Network for HMHA1
     Regulatory tfbs in HMHA1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HMHA1 GenScript cDNA clones with any tag delivered in your preferred vector for HMHA1
     GenScript Custom Assay Services for HMHA1 GenScript Custom overexpressing Cell Line Services for HMHA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HMHA1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HMHA1 antibodies
     HMHA1 proteins
     HMHA1 lysates
     Antibodies for HMHA1
     See all of Abcam's Antibodies, Kits and Proteins for HMHA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HMHA1
     Antibodies for HMHA1
     ELISAs for HMHA1
     CLIAs for HMHA1



     Browse ESI BIO Cell Lines and PureStem Progenitors for HMHA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMHA1
     SwitchGear 3'UTR luciferase reporter plasmids for HMHA1
     SwitchGear Promoter luciferase reporter plasmids for HMHA1
     Search ThermoFisher Antibodies for HMHA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMHA1
     Browse compounds at ApexBio
     Search Addgene for plasmids for HMHA1
      Search eBioscience for proteins for HMHA1
      Search eBioscience for elisas for HMHA1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HMHA1
     antibodies-online antibodies for HMHA1 (22 products)
     antibodies-online kits for HMHA1 (4 products)
     antibodies-online peptides for HMHA1
     antibodies-online proteins for HMHA1 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HMHA1 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4