HMHA1 Gene
protein-coding GIFtS: 55
GCID: GC19P001066
|
|
histocompatibility (minor) HA-1
| |
Aliases
for HMHA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Histocompatibility (Minor) HA-11 2 | | HLA-HA12 5 | | KIAA02231 3 5 | | Minor Histocompatibility Antigen HA-12 | | ARHGAP451 2 | | Minor Histocompatibility Protein HA-12 | | HA-11 2 | | |
Export aliases for HMHA1 gene to outside databasesPrevious GC identifers: GC19P001019 GC19P000841 |
Summaries
for HMHA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HMHA1_HUMAN, Q92619Function: GTPase activator for the Rho-type GTPases (Potential)Function: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags)refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition byspecific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normalpathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expressionon the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease(GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complicationafter bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched siblingmarrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to beassociated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHCclass I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte(CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cellrecognition and lysis by CTL
Gene Wiki entry for HMHA1
|
Genomic Views
for HMHA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HMHA1 gene promoter:
Sox5 Tal-1 SREBP-1c MIF-1 Tal-1beta E47 SREBP-1b AREB6 SREBP-1a ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HMHA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMHA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3HMHA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P001066: view genomic region
(about GC identifiers)
Start:
|
1,065,922 bp from pter |
End:
|
1,086,627 bp from pter |
Size:
|
20,706 bases |
Orientation:
|
plus strand |
|
Proteins
for HMHA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HMHA1_HUMAN, Q92619 (See
protein sequence)Recommended Name: Minor histocompatibility protein HA-1 Size: 1136 amino acids; 124614 Da
Subunit: HA-1 forms a complex with MHC class I HLA-A*0201
Miscellaneous: Infusion of lymphocyte from mHag HA-1-negative donors results in a durable remission in mHagHA-1-positive patients with leukemia or multiple myeloma
Sequence caution: Sequence=BAA13212.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for HMHA1:3D25 (3D)
Secondary accessions: B4DTS4 F6QP70 Q6P189 Q7LE26 Q86WS1 Q8HX84 Q9GJN9 Q9GJP0 Q9GJP1 Q9MY24Alternative splicing: 2 isoforms: Q92619-1 Q92619-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HMHA1: NX_Q92619
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92619
HMHA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001245257.1 NP_036424.2
ENSEMBL proteins: ENSP00000439601 ENSP00000467741 ENSP00000316772 ENSP00000466365 ENSP00000466401 ENSP00000468615 ENSP00000438979 ENSP00000467525 ENSP00000468607 ENSP00000445109 Reactome Protein details: Q92619
Human Recombinant Protein Products for HMHA1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HMHA1 for ontologies About GeneDecksing
HMHA1 Antibody Products:
Assay Products for HMHA1: |
Protein
Domains /
Families
for HMHA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HMHA1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92619ProtoNet protein and cluster: Q92619 1 Blocks protein family: IPB000198 RhoGAP domain
UniProtKB/Swiss-Prot: HMHA1_HUMAN, Q92619Similarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 1 Rho-GAP domain |
Function
for HMHA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: HMHA1_HUMAN, Q92619Function: GTPase activator for the Rho-type GTPases (Potential)Function: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags)refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition byspecific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normalpathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expressionon the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease(GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complicationafter bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched siblingmarrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to beassociated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHCclass I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte(CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cellrecognition and lysis by CTL Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005096 | GTPase activator activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
HMHA1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for HMHA1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMHA1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMHA1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HMHA1 (NM_012292) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMHA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMHA1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMHA1 |
|
Pathways & Interactions
for HMHA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for HMHA1
HMHA1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HMHA1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/34 Interacting proteins for HMHA1 (ENSP000003167724) via UniProtKB, MINT, STRING, and/or I2D (see all 34)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
TAS | -- | | GO:0035556 | intracellular signal transduction |
-- | -- | | GO:0051056 | regulation of small GTPase mediated signal transduction |
TAS | -- |
HMHA1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HMHA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HMHA1
10/843 HMDB Compounds for HMHA1 (see all 843) About this table
Search CenterWatch for drugs/clinical trials and news about HMHA1
|
Transcripts
for HMHA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HMHA1 gene (2 alternative transcripts): NM_001258328.1 NM_012292.3 Unigene Cluster for HMHA1: Histocompatibility (minor) HA-1 Hs.465521 [show with all ESTs]Unigene Representative Sequence: BC06522317 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000539243 ENST00000587186 ENST00000313093(uc010xgd.1 uc002lqz.1 uc010xge.1 uc002lra.1)
ENST00000587602 ENST00000591293 ENST00000590214 ENST00000586866 ENST00000543365(uc002lrb.1 uc002lrc.1)
ENST00000592335 ENST00000586033 ENST00000590577 ENST00000586937 ENST00000590512
ENST00000586378 ENST00000592297 ENST00000591169 ENST00000536472
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMHA1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMHA1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HMHA1 (NM_012292) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMHA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMHA1 |
Additional cDNA sequence: AK122776.1 AK128097.1 AK300341.1 AK304271.1 BC035564.1 BC048129.1 BC065223.1 D86976.1 NR_047652.1 19 DOTS entries: DT.101983553 DT.95136574 DT.97772339 DT.442145 DT.101983552 DT.99991844 DT.100741848 DT.100817986 DT.121441251 DT.95136591 DT.92430507 DT.100817992 DT.121441246 DT.121441517 DT.121441524 DT.121441602 DT.95136573 DT.95298816 DT.40221910 24/193 AceView cDNA sequences (see all 193): BM714648 AI457902 BM807016 AL041721 BQ878430 BQ030276 AI270222 AI674929 BE208751 BQ705987 BU838153 BQ682808 BU616439 AW793644 BQ049726 NM_012292 CR608309 BC048129 BX337482 BG388120 CR603358 BM563604 AL560092 BQ689919
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for HMHA1 (see all 11) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ |
|---|
|
| SP1: | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | |
| ExUns: | 23 | ^ | 24a | · | 24b | · | 24c | · | 24d | ^ | 25a | · | 25b | · | 25c | ^ | 26 | ^ | 27a | · | 27b | · | 27c |
|---|
|
| SP1: | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HMHA1
|
Expression
for HMHA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HMHA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGCTCCGTG
About this image
See HMHA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HMHA1
SOURCE GeneReport for Unigene cluster: Hs.465521
UniProtKB/Swiss-Prot: HMHA1_HUMAN, Q92619Tissue specificity: Expressed on cells of the hematopoietic lineage. Detected in dendritic cells and epidermalLangerhans cells. Expressed in peripheral blood mononuclear cells, in all leukemia/lymphoma cell lines. Detected alsoin some solid tumors and tissues such as cancerous and non-cancerous tissue
SABiosciences Custom PCR Arrays for HMHA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMHA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HMHA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMHA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMHA1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMHA1 |
Orthologs
for HMHA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HMHA1 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HMHA11 |
histocompatibility (minor) HA-1 |
73.94(n)
71.53(a) |
|
420102 NM_001030937.1 NP_001026108.1 |
lizard
(Anolis carolinensis) |
Reptilia |
HMHA16 |
-- |
65(a) |
1 ↔ 1 |
GL344210.1(29132-61282) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.113972 |
Transcribed sequence with weak similarity to protein more |
74.11(n) |
|
BX739199.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
hmha11 |
histocompatibility (minor) HA-1 |
61.88(n)
58.68(a) |
|
555849 XM_678493.4 XP_683585.4 |
worm
(Caenorhabditis elegans) |
Secernentea |
rga-56tag-3416 |
Protein RGA-5, isoform bTemporarily Assigned Gene name family member (tag-... |
5(a)21(a) |
possible ortholog1 ↔ many |
IV(13827861-13844953) II(7912715-7928604) |
ENSEMBL Gene Tree for HMHA1 (if available)
TreeFam Gene Tree for HMHA1 (if available) |
Paralogs
for HMHA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HMHA1 gene
- ARHGAP212 ARHGAP272 CHN22 ARHGAP102 ARHGAP232 ARHGAP92 ARHGAP292 ARHGAP262
- CHN12 ARHGAP152 ARHGAP122 OPHN12 GMIP2 ARHGAP422
12 SIMAP similar genes for HMHA1 using alignment to 10 protein entries: HMHA1_HUMAN (see all proteins):ARHGAP24 OPHN1 ARHGAP21 ARHGAP31 ARHGAP29 ARHGAP12
ARHGAP23 CHN2 CHN1 GMIP ABR ARHGAP5
HMHA1 for paralogs About GeneDecksing
|
Genomic Variants
for HMHA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: HMHA1_HUMAN, Q92619Polymorphism: The HA-1H allele is presented on the cell surface and recognized by CTL, whereas the HA-1R allele ispoorly represented by HLA-A and non-immunogenic, although HA-1R allelic frequency is the highest
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HMHA1 (1065922 - 1086627 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for HMHA1
5 CNVs: 4066 2237 29682 5065 30885
Human Gene Mutation Database (HGMD): HMHA1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMHA1 |
|
Disorders
/ Diseases
for HMHA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HMHA1 for disorders About GeneDecksing
OMIM gene information: 601155
OMIM disorders: --
14  diseases for HMHA1: About MalaCardsgraft versus host disease acute graft versus host disease leukemia/lymphoma leukemia/lymphoma, t-cell
chronic myeloid leukemia myeloid leukemia sjogren's syndrome multiple myeloma
leukemia myeloma hematopoiesis nephropathy
cholesterol melanoma
9 Novoseek disease relationships for HMHA1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| graft-versus-host disease |
81.5 |
5 |
11144294 (1), 16707472 (1), 10703604 (1), 15350465 (1) (see all 5) |
| graft-versus-tumor |
71.2 |
1 |
16399573 (1) |
| acute graft-versus-host disease |
70.7 |
5 |
10515896 (2), 11564088 (2), 9820595 (1) |
| hematologic malignancies |
47.3 |
3 |
16399573 (2), 12601144 (1) |
| solid tumor |
41.7 |
9 |
19096014 (3), 11965046 (3), 12804533 (1), 16399573 (1) |
| leukemia |
40.6 |
8 |
11965046 (3), 17641837 (1), 12601144 (1), 14502255 (1) (see all 5) |
| necrosis |
0 |
1 |
12438965 (1) |
| tumors |
0 |
4 |
19096014 (2), 12438965 (1), 11965046 (1) |
| cancer |
0 |
5 |
19096014 (2), 12163564 (1), 11965046 (1), 16399573 (1) |
Human Genome Epidemiology (HuGE) Navigator: HMHA1 (7 documents)
Export disorders for HMHA1 gene to outside databases
|
Publications
for HMHA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HMHA1 gene, integrated from 9 sources (see all 72):
(articles sorted by number of sources associating them with HMHA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T....Nomura N. (1996)
- Expression of minor histocompatibility antigen, HA-1, in solid tumor cells. (PubMed id 11965046)1, 2, 9 Fujii N....Harada M. (2002)
- Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA). (PubMed id 10958358)1, 2, 9 Arostegui J.I.... Granena A. (2000)
- Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene. (PubMed id 11095984)1, 2, 9 Kaminski W.E.... Schmitz G. (2000)
- Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR. (PubMed id 9820596)1, 3, 9 Wilke M....Goulmy E. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells. (PubMed id 8843592)1, 2 van Lochem E.... Goulmy E. (1996)
- Therapeutic and diagnostic applications of minor histocompatibility antigen HA-1 and HA-2 disparities in allogeneic hematopoietic stem cell transplantation: a survey of different populations. (PubMed id 16399573)2, 9 Di Terlizzi S....Fleischhauer K. (2006)
- Quantification of the HA-1 gene product at the RNA level; relevance for immunotherapy of hematological malignancies. (PubMed id 14502255)1, 9 Wilke M....Goulmy E. (2003)
- Sequence diversity within the HA-1 gene as detected by melting temperature assay without oligonucleotide probes. (PubMed id 16202172)2, 9 Graziano C.... Porfirio B. (2005)
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External Searches for HMHA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing HMHA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing HMHA1 gene
(According to HUGE)
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Specialized Databases showing HMHA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for HMHA1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for HMHA1 gene:
Search GeneIP for patents involving HMHA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HMHA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HMHA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMHA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMHA1 | | | OriGene Protein Over-expression Lysate for HMHA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HMHA1 | | OriGene 3'-UTR Clone for HMHA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMHA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMHA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HMHA1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HMHA1 | | OriGene Custom Protein Services for HMHA1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HMHA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMHA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMHA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMHA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMHA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMHA1 |
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| | | | Search Tocris compounds for HMHA1 |
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 | | | HMHA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMHA1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for HMHA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMHA1 |
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