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Aliases for HMGXB4 Gene

Aliases for HMGXB4 Gene

  • HMG Box Domain Containing 4 2 3
  • HMG2L1 3 4 6
  • High-Mobility Group Protein 2-Like 1 2 3
  • High Mobility Group Protein 2-Like 1 3 4
  • HMG Box-Containing Protein 4 3 4
  • HMGBCG 3 4
  • HMG Domain-Containing Protein 4 3
  • Protein HMGBCG 4
  • THC211630 3

External Ids for HMGXB4 Gene

Previous HGNC Symbols for HMGXB4 Gene

  • HMG2L1

Previous GeneCards Identifiers for HMGXB4 Gene

  • GC22P033983
  • GC22P035653
  • GC22P018614

Summaries for HMGXB4 Gene

Entrez Gene Summary for HMGXB4 Gene

  • High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010]

GeneCards Summary for HMGXB4 Gene

HMGXB4 (HMG Box Domain Containing 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HMGXB4 Gene

  • Negatively regulates Wnt/beta-catenin signaling during development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGXB4 Gene

Genomics for HMGXB4 Gene

Regulatory Elements for HMGXB4 Gene

Genomic Location for HMGXB4 Gene

Start:
35,257,345 bp from pter
End:
35,295,807 bp from pter
Size:
38,463 bases
Orientation:
Plus strand

Genomic View for HMGXB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMGXB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGXB4 Gene

Proteins for HMGXB4 Gene

  • Protein details for HMGXB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGU5-HMGX4_HUMAN
    Recommended name:
    HMG domain-containing protein 4
    Protein Accession:
    Q9UGU5
    Secondary Accessions:
    • O75672
    • O75673
    • Q9UMT5

    Protein attributes for HMGXB4 Gene

    Size:
    601 amino acids
    Molecular mass:
    65712 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HMGXB4 Gene

Proteomics data for HMGXB4 Gene at MOPED

Post-translational modifications for HMGXB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMGXB4 Gene

No data available for DME Specific Peptides for HMGXB4 Gene

Domains for HMGXB4 Gene

Gene Families for HMGXB4 Gene

HGNC:
  • HMGX :High mobility group / Non-canonical

Protein Domains for HMGXB4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UGU5

UniProtKB/Swiss-Prot:

HMGX4_HUMAN :
  • Q9UGU5
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with HMGXB4: view

Function for HMGXB4 Gene

Molecular function for HMGXB4 Gene

UniProtKB/Swiss-Prot Function: Negatively regulates Wnt/beta-catenin signaling during development.

Gene Ontology (GO) - Molecular Function for HMGXB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA --
genes like me logo Genes that share ontologies with HMGXB4: view

Animal Model Products

CRISPR Products

miRNA for HMGXB4 Gene

miRTarBase miRNAs that target HMGXB4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HMGXB4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HMGXB4 Gene

Localization for HMGXB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGXB4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMGXB4 Gene COMPARTMENTS Subcellular localization image for HMGXB4 gene
Compartment Confidence
nucleus 5
cytosol 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HMGXB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016589 NURF complex IDA 20850016
genes like me logo Genes that share ontologies with HMGXB4: view

Pathways for HMGXB4 Gene

SuperPathways for HMGXB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HMGXB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IBA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0008333 endosome to lysosome transport NAS 10329004
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway ISS --
genes like me logo Genes that share ontologies with HMGXB4: view

No data available for Pathways by source for HMGXB4 Gene

Transcripts for HMGXB4 Gene

Unigene Clusters for HMGXB4 Gene

HMG box domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HMGXB4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HMGXB4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMGXB4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
SP1: -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for HMGXB4 Gene

GeneLoc Exon Structure for
HMGXB4
ECgene alternative splicing isoforms for
HMGXB4

Expression for HMGXB4 Gene

mRNA expression in normal human tissues for HMGXB4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMGXB4 Gene

SOURCE GeneReport for Unigene cluster for HMGXB4 Gene Hs.588815

genes like me logo Genes that share expressions with HMGXB4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HMGXB4 Gene

Orthologs for HMGXB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HMGXB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMGXB4 35
  • 99.61 (n)
  • 99.67 (a)
HMGXB4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HMGXB4 35
  • 89.02 (n)
  • 93.29 (a)
HMGXB4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMGXB4 35
  • 91.22 (n)
  • 94.83 (a)
HMGXB4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmgxb4 35
  • 85.35 (n)
  • 87.88 (a)
Hmgxb4 16
Hmgxb4 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HMGXB4 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HMGXB4 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmgxb4 35
  • 83.28 (n)
  • 86.01 (a)
chicken
(Gallus gallus)
Aves HMGXB4 35
  • 72.94 (n)
  • 73.75 (a)
HMGXB4 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HMGXB4 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia HMG2L1 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hmgxb4 35
  • 63.21 (n)
  • 63.96 (a)
Str.822 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6678 35
zebrafish
(Danio rerio)
Actinopterygii hmgxb4a 36
  • 52 (a)
OneToMany
hmgxb4b 36
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4617 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.702 36
  • 29 (a)
OneToOne
Species with no ortholog for HMGXB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMGXB4 Gene

ENSEMBL:
Gene Tree for HMGXB4 (if available)
TreeFam:
Gene Tree for HMGXB4 (if available)

Paralogs for HMGXB4 Gene

No data available for Paralogs for HMGXB4 Gene

Variants for HMGXB4 Gene

Sequence variations from dbSNP and Humsavar for HMGXB4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs14659 -- 35,265,431(+) AGGAC(C/T)TTCTG missense, reference, nc-transcript-variant
rs138718 -- 35,260,658(+) TTCAT(-/T)ACTCT intron-variant
rs713770 -- 35,271,982(+) ATTCA(A/G)TAAAT intron-variant
rs737754 -- 35,268,680(+) acttg(A/T)caaag intron-variant
rs737755 -- 35,272,059(+) TTGGG(C/T)GTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMGXB4 Gene

Variant ID Type Subtype PubMed ID
nsv914994 CNV Loss 21882294
esv2170801 CNV Deletion 18987734

Relevant External Links for HMGXB4 Gene

HapMap Linkage Disequilibrium report
HMGXB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGXB4 Gene

Disorders for HMGXB4 Gene

Relevant External Links for HMGXB4

Human Genome Epidemiology (HuGE) Navigator
HMGXB4
genes like me logo Genes that share disorders with HMGXB4: view

No data available for UniProtKB/Swiss-Prot for HMGXB4 Gene

Publications for HMGXB4 Gene

  1. TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. (PMID: 10329004) Seroussi E. … Dumanski J.P. (Genomics 1999) 2 3 4
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  3. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins J.E. … Dunham I. (Genome Res. 2003) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1. (PMID: 20511232) Zhou J. … Wang X. (J. Biol. Chem. 2010) 2 3

Products for HMGXB4 Gene

Sources for HMGXB4 Gene

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