Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HMGXB4 Gene

Aliases for HMGXB4 Gene

  • HMG-Box Containing 4 2 3
  • HMG Box Domain Containing 4 2 3 5
  • High-Mobility Group Protein 2-Like 1 2 3
  • High Mobility Group Protein 2-Like 1 3 4
  • HMG Box-Containing Protein 4 3 4
  • HMG2L1 3 4
  • HMGBCG 3 4
  • Protein HMGBCG 4
  • THC211630 3

External Ids for HMGXB4 Gene

Previous HGNC Symbols for HMGXB4 Gene

  • HMG2L1

Previous GeneCards Identifiers for HMGXB4 Gene

  • GC22P033983
  • GC22P035653
  • GC22P018614
  • GC22P035257

Summaries for HMGXB4 Gene

Entrez Gene Summary for HMGXB4 Gene

  • High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010]

GeneCards Summary for HMGXB4 Gene

HMGXB4 (HMG-Box Containing 4) is a Protein Coding gene. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for HMGXB4 Gene

  • Negatively regulates Wnt/beta-catenin signaling during development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGXB4 Gene

Genomics for HMGXB4 Gene

Regulatory Elements for HMGXB4 Gene

Enhancers for HMGXB4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HMGXB4 on UCSC Golden Path with GeneCards custom track

Genomic Location for HMGXB4 Gene

35,241,535 bp from pter
35,295,807 bp from pter
54,273 bases
Plus strand

Genomic View for HMGXB4 Gene

Genes around HMGXB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMGXB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMGXB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGXB4 Gene

Proteins for HMGXB4 Gene

  • Protein details for HMGXB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HMG domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • O75672
    • O75673
    • Q9UMT5

    Protein attributes for HMGXB4 Gene

    601 amino acids
    Molecular mass:
    65712 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HMGXB4 Gene

Proteomics data for HMGXB4 Gene at MOPED

Post-translational modifications for HMGXB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMGXB4 Gene

No data available for DME Specific Peptides for HMGXB4 Gene

Domains & Families for HMGXB4 Gene

Gene Families for HMGXB4 Gene

Protein Domains for HMGXB4 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 HMG box DNA-binding domain.
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with HMGXB4: view

Function for HMGXB4 Gene

Molecular function for HMGXB4 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates Wnt/beta-catenin signaling during development.
genes like me logo Genes that share phenotypes with HMGXB4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMGXB4 Gene

Localization for HMGXB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGXB4 Gene

Subcellular locations from

Jensen Localization Image for HMGXB4 Gene COMPARTMENTS Subcellular localization image for HMGXB4 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for HMGXB4 Gene

Pathways & Interactions for HMGXB4 Gene

SuperPathways for HMGXB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HMGXB4 Gene


No data available for Pathways by source and SIGNOR curated interactions for HMGXB4 Gene

Drugs & Compounds for HMGXB4 Gene

No Compound Related Data Available

Transcripts for HMGXB4 Gene

Unigene Clusters for HMGXB4 Gene

HMG box domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMGXB4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
SP1: -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP7: -

Relevant External Links for HMGXB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HMGXB4 Gene

mRNA expression in normal human tissues for HMGXB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HMGXB4 Gene

This gene is overexpressed in Platelet (26.1), Placenta (22.0), and Fetal ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMGXB4 Gene

SOURCE GeneReport for Unigene cluster for HMGXB4 Gene Hs.588815

genes like me logo Genes that share expression patterns with HMGXB4: view

Protein tissue co-expression partners for HMGXB4 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HMGXB4 Gene

Orthologs for HMGXB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HMGXB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HMGXB4 35
  • 89.02 (n)
  • 93.29 (a)
  • 94 (a)
(Canis familiaris)
Mammalia HMGXB4 35
  • 91.22 (n)
  • 94.83 (a)
  • 95 (a)
(Mus musculus)
Mammalia Hmgxb4 35
  • 85.35 (n)
  • 87.88 (a)
Hmgxb4 16
Hmgxb4 36
  • 88 (a)
(Pan troglodytes)
Mammalia HMGXB4 35
  • 99.61 (n)
  • 99.67 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Hmgxb4 35
  • 83.28 (n)
  • 86.01 (a)
(Monodelphis domestica)
Mammalia HMGXB4 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia HMGXB4 36
  • 69 (a)
(Gallus gallus)
Aves HMGXB4 35
  • 72.94 (n)
  • 73.75 (a)
  • 73 (a)
(Anolis carolinensis)
Reptilia HMGXB4 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hmgxb4 35
  • 63.21 (n)
  • 63.96 (a)
Str.822 35
African clawed frog
(Xenopus laevis)
Amphibia HMG2L1 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6678 35
(Danio rerio)
Actinopterygii hmgxb4a 36
  • 52 (a)
hmgxb4b 36
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4617 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.702 36
  • 29 (a)
Species with no ortholog for HMGXB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMGXB4 Gene

Gene Tree for HMGXB4 (if available)
Gene Tree for HMGXB4 (if available)

Paralogs for HMGXB4 Gene

No data available for Paralogs for HMGXB4 Gene

Variants for HMGXB4 Gene

Sequence variations from dbSNP and Humsavar for HMGXB4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1053593 - 35,264,882(+) TGGTG(C/G/T)CTCCC nc-transcript-variant, reference, missense
rs14659 -- 35,265,431(+) AGGAC(C/T)TTCTG nc-transcript-variant, reference, missense
rs2179050 -- 35,282,263(+) GCTCC(A/G)CCTCC intron-variant
rs2235147 -- 35,268,334(+) ATTTC(C/T)GCACA intron-variant
rs2235148 -- 35,268,948(+) ACCCC(C/T)CATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMGXB4 Gene

Variant ID Type Subtype PubMed ID
nsv914994 CNV Loss 21882294
esv2170801 CNV Deletion 18987734

Variation tolerance for HMGXB4 Gene

Residual Variation Intolerance Score: 12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.13; 84.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HMGXB4 Gene

Disorders for HMGXB4 Gene

Relevant External Links for HMGXB4

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HMGXB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMGXB4 Gene

Publications for HMGXB4 Gene

  1. TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. (PMID: 10329004) Seroussi E. … Dumanski J.P. (Genomics 1999) 2 3 4 67
  2. Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1. (PMID: 20511232) Zhou J. … Wang X. (J. Biol. Chem. 2010) 2 3
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3
  4. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho C.E. … Valentini S.R. (Exp. Cell Res. 2015) 3
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3

Products for HMGXB4 Gene

Sources for HMGXB4 Gene