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HMGXB4 Gene

protein-coding   GIFtS: 47
GCID: GC22P035653

HMG Box Domain Containing 4

(Previous name: high-mobility group protein 2-like 1)
(Previous symbol: HMG2L1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HMG Box Domain Containing 41 2     HMG Box-Containing Protein 42 3
HMG2L11 2 3 5     THC2116302
High-Mobility Group Protein 2-Like 11 2     HMG Domain-Containing Protein 42
High Mobility Group Protein 2-Like 12 3     Protein HMGBCG3
HMGBCG2 3     

External Ids:    HGNC: 50031   Entrez Gene: 100422   Ensembl: ENSG000001002817   OMIM: 6047025   UniProtKB: Q9UGU53   

Export aliases for HMGXB4 gene to outside databases

Previous GC identifers: GC22P033983 GC22P018614


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HMGXB4 Gene:
High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional
information on HMG proteins.(supplied by OMIM, Nov 2010)

GeneCards Summary for HMGXB4 Gene:
HMGXB4 (HMG box domain containing 4) is a protein-coding gene.

UniProtKB/Swiss-Prot: HMGX4_HUMAN, Q9UGU5
Function: Negatively regulates Wnt/beta-catenin signaling during development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HMGXB4 gene promoter:
         GR   c-Fos   AP-1   AML1a   p300   RREB-1   POU6F1 (c2)   Ik-2   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHMGXB4 promoter sequence
   Search Chromatin IP Primers for HMGXB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMGXB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13

HMGXB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMGXB4 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P035653:  view genomic region     (about GC identifiers)

Start:
35,653,445 bp from pter      End:
35,691,800 bp from pter
Size:
38,356 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HMGX4_HUMAN, Q9UGU5 (See protein sequence)
Recommended Name: HMG domain-containing protein 4  
Size: 601 amino acids; 65712 Da
Secondary accessions: O75672 O75673 Q9UMT5

Explore the universe of human proteins at neXtProt for HMGXB4: NX_Q9UGU5

Explore proteomics data for HMGXB4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HMGXB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001003681.1  
    ENSEMBL proteins: 
     ENSP00000401658   ENSP00000395532   ENSP00000415500   ENSP00000216106   ENSP00000398302  

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for HMGXB4 (4 products) 

     
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    antibodies-online antibodies for HMGXB4 (11 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HMGX: High mobility group / Non-canonical

    2 InterPro protein domains:
     IPR025228 DUF4171
     IPR009071 HMG_box_dom

    Graphical View of Domain Structure for InterPro Entry Q9UGU5

    ProtoNet protein and cluster: Q9UGU5

    UniProtKB/Swiss-Prot: HMGX4_HUMAN, Q9UGU5
    Similarity: Contains 1 HMG box DNA-binding domain


    Find genes that share domains with HMGXB4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMGX4_HUMAN, Q9UGU5
    Function: Negatively regulates Wnt/beta-catenin signaling during development (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    Find genes that share ontologies with HMGXB4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HMGXB4

    miRNA
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    miRTarBase miRNAs that target HMGXB4:
    hsa-mir-186-5p (MIRT021175), hsa-mir-30c-5p (MIRT047935), hsa-mir-221-3p (MIRT003368)

    Block miRNA regulation of human, mouse, rat HMGXB4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HMGXB4 (see all 40):
    hsa-miR-300 hsa-miR-15a hsa-miR-624* hsa-miR-570 hsa-miR-424 hsa-miR-124 hsa-miR-506 hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidHMGXB4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HMGXB4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGXB4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HMGX4_HUMAN, Q9UGU5: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0016589NURF complex IDA--

    Find genes that share ontologies with HMGXB4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HMGXB4
    Interactions:

        Search GeneGlobe Interaction Network for HMGXB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for HMGXB4 (Q9UGU52, 3 ENSP000002161064) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR1H2P550552, 3MINT-8263885 I2D: score=2 
    TNNT1P138052, 3MINT-8274907 I2D: score=2 
    TSC22D1Q157142, 3MINT-8275402 I2D: score=2 
    URODP061322, 3, ENSP000002463374MINT-8276916 I2D: score=2 STRING: ENSP00000246337
    HABP4Q5JVS03, ENSP000003643984I2D: score=2 STRING: ENSP00000364398
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008333endosome to lysosome transport NAS10329004
    GO:0016055Wnt signaling pathway IEA--
    GO:0030178negative regulation of Wnt signaling pathway ISS--

    Find genes that share ontologies with HMGXB4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HMGXB4 (HMGX4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HMGXB4 gene (3 alternative transcripts): 
    NM_005487.3  NM_014250.1  NM_001003681.2  

    Unigene Cluster for HMGXB4:

    HMG box domain containing 4
    Hs.588815  [show with all ESTs]
    Unigene Representative Sequence: NR_027780
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420166 ENST00000418170(uc003ank.3 uc003anl.3) ENST00000466438
    ENST00000455359 ENST00000216106 ENST00000498325 ENST00000464480 ENST00000498212
    ENST00000444518(uc011amh.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HMGXB4 (see all 40):
    hsa-miR-300 hsa-miR-15a hsa-miR-624* hsa-miR-570 hsa-miR-424 hsa-miR-124 hsa-miR-506 hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidHMGXB4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HMGXB4
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HMGXB4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HMGXB4
      QuantiTect SYBR Green Assays in human, mouse, rat HMGXB4
      QuantiFast Probe-based Assays in human, mouse, rat HMGXB4

    Additional mRNA sequence: 

    AJ010069.1 AJ010070.1 AK299833.1 AL079310.1 BC004194.2 BC011723.2 BC017326.2 BC025303.2 
    BC033783.2 BC040447.1 BC052624.1 BC062413.1 BC080611.1 BC104754.1 BC104756.1 BC111373.1 
    CR456504.1 NR_027780.1 

    13 DOTS entries:

    DT.414194  DT.97835740  DT.101960334  DT.100820014  DT.100655215  DT.100035944  DT.100696551  DT.97807146 
    DT.91755099  DT.91874892  DT.95260231  DT.95274258  DT.95274259 

    Selected AceView cDNA sequences (see all 224):

    BC033783 AI203042 AA595227 BF056467 BE877254 AI365200 AW073484 BQ012590 
    BE855495 AI359479 CF529434 AW004073 AI151182 BC080611 AI188726 AI470722 
    BC004194 CB242414 AJ010070 BC052624 AI376174 BC017326 BQ013268 BF507884 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HMGXB4 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
    SP1:                                                                                            -                                 
    SP2:              -     -           -                                                                                             
    SP3:              -     -     -     -                                                                                             
    SP4:              -     -           -                 -                                                                           
    SP5:              -     -     -     -                 -                                                                           


    ECgene alternative splicing isoforms for HMGXB4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HMGXB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATAGTATAG
    HMGXB4 Expression
    About this image

    HMGXB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMGXB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.588815
        Custom PCR Arrays for HMGXB4
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HMGXB4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmgxb41 , 5 HMG box domain containing 41, 5 85.35(n)1
    87.88(a)1
      8 (35.57 cM)5
    708231  NM_178017.11  NP_821136.11 
     749933565 
    chicken
    (Gallus gallus)
    Aves HMGXB41 HMG box domain containing 4 72.94(n)
    73.75(a)
      418059  XM_416295.4  XP_416295.4 
    lizard
    (Anolis carolinensis)
    Reptilia HMGXB46
    HMG box domain containing 4
    72(a)
    1 ↔ 1
    5(21405671-21425449)
    African clawed frog
    (Xenopus laevis)
    Amphibia HMG2L12 HMG-box protein HMG2L1 77.3(n)    AY281348.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmgxb4a6
    hmgxb4b6
    HMG box domain containing 4b
    52(a)
    34(a)
    many → 1
    many → 1
    3(26975060-26990138) ENSDARG00000075783
    Zv9_NA129(4183-8616) ENSDARG00000091401
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46176
    --
    26(a)
    1 ↔ 1
    X(6996352-6998524)


    ENSEMBL Gene Tree for HMGXB4 (if available)
    TreeFam Gene Tree for HMGXB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HMGXB4 (see all 847)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs359841181,2
    C--19595756(+) TCTAC-/AAAA  
            
    AAAAA
    2 -- int10--------
    rs1178229961,2
    F--35651452(+) GCAGTG/AAGCTG 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1881972441,2
    --35651460(+) CTGTGA/CTCGTG 2 -- us2k10--------
    rs1499582251,2
    C--35651537(+) CCACAA/GGGACA 2 -- us2k10--------
    rs81419381,2
    C,F--35651584(+) ggagTC/TATCAC 2 -- us2k12Minor allele frequency- T:0.20WA 120
    rs57500901,2
    C,A,H--35651726(+) ctcttC/Ttgggg 2 -- us2k1 trp34Minor allele frequency- T:0.00NS EA 418
    rs1809911081,2
    --35651779(+) GACCAA/GTGGAT 2 -- us2k10--------
    rs1864913541,2
    --35651797(+) TCTGAA/GGAACA 2 -- us2k10--------
    rs1897788921,2
    --35651800(+) GAAGAA/CCAAAA 2 -- us2k10--------
    rs1464776241,2
    C--35651882(+) GCAATA/CTAACA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HMGXB4 (35653445 - 35691800 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HMGXB4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2170801CNV Deletion18987734
    nsv914994CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HMGXB4
    DNA2.0 Custom Variant and Variant Library Synthesis for HMGXB4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604702    OMIM disorders: --


    Find genes that share disorders with HMGXB4           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: HMGXB4 (0 documents)

    Export disorders for HMGXB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HMGXB4 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with HMGXB4)
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    1. TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. (PubMed id 10329004)1, 2, 3 Seroussi E....Dumanski J.P. (Genomics 1999)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    3. Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1. (PubMed id 20511232)1, 3 Zhou J....Wang X. (J. Biol. Chem. 2010)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    5. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (Genome Res. 2003)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10042 HGNC: 5003 AceView: HMG2L1 Ensembl:ENSG00000100281 euGenes: HUgn10042
    ECgene: HMGXB4 H-InvDB: HMGXB4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HMGXB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HMGXB4 gene:
    Search GeneIP for patents involving HMGXB4

    GeneCards and IP:
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