Aliases for HMGXB3 Gene
Aliases for HMGXB3 Gene
External Ids for HMGXB3 Gene
- HGNC: 28982
- Entrez Gene: 22993
- Ensembl: ENSG00000113716
- UniProtKB: Q12766
Previous HGNC Symbols for HMGXB3 Gene
- HMGX3
Previous GeneCards Identifiers for HMGXB3 Gene
- GC05P149361
- GC05P144528
Summaries for HMGXB3 Gene
-
This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. [provided by RefSeq, Aug 2011]
GeneCards Summary for HMGXB3 Gene
HMGXB3 (HMG-Box Containing 3) is a Protein Coding gene. GO annotations related to this gene include kinase activity.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGXB3 Gene
Genomics for HMGXB3 Gene
Regulatory Elements for HMGXB3 Gene
Enhancers for HMGXB3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HMGXB3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HMGXB3 gene promoter:
Regulatory Element Products
Genomic Location for HMGXB3 Gene
- Chromosome:
- 5
- Start:
- 150,000,046 bp from pter
- End:
- 150,053,143 bp from pter
- Size:
- 53,098 bases
- Orientation:
- Plus strand
Genomic View for HMGXB3 Gene
Genes around HMGXB3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q32 by Ensembl
- 5q32 by Entrez Gene
- 5q32 by HGNC
HMGXB3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMGXB3 Gene
Proteins for HMGXB3 Gene
-
Protein details for HMGXB3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12766-HMGX3_HUMAN
- Recommended name:
- HMG domain-containing protein 3
- Protein Accession:
- Q12766
- G5E9Y4
- Q86UG3
- Q9UMF4
Protein attributes for HMGXB3 Gene
- Size:
- 1538 amino acids
- Molecular mass:
- 168334 Da
- Quaternary structure:
- No Data Available
Protein Expression for HMGXB3 Gene
Post-translational modifications for HMGXB3 Gene
Other Protein References for HMGXB3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HMGXB3
- Invitrogen Antibodies for HMGXB3
- antibodies-online Antibodies for HMGXB3: See all 24
- GeneTex HMGXB3 antibody for HMGXB3
Protein Products
-
OriGene Purified Proteins for HMGXB3
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGXB3
- Origene Custom Protein Services for HMGXB3
- Search GeneTex for Proteins for HMGXB3
Assay Products
No data available for DME Specific Peptides for HMGXB3 Gene
Domains & Families for HMGXB3 Gene
Gene Families for HMGXB3 Gene
Protein Domains for HMGXB3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMGXB3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HMGXB3 Gene
Function for HMGXB3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0016301 | kinase activity | NAS | 9027509 |
Phenotypes for HMGXB3 Gene
- MGI mutant phenotypes for HMGXB3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HMGXB3:
Animal Models for HMGXB3 Gene
- MGI Knock Outs for HMGXB3:
-
- Hmgxb3 tm1a(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGXB3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGXB3 gene
- Search ViGene Biosciences for HMGXB3
CRISPR Products
-
OriGene CRISPR knockouts for HMGXB3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGXB3
- GenScript: Design CRISPR guide RNA sequences for HMGXB3
miRNA for HMGXB3 Gene
- miRTarBase miRNAs that target HMGXB3
-
- hsa-mir-454-3p (MIRT039237)
- hsa-mir-615-3p (MIRT040316)
- hsa-mir-484 (MIRT041726)
- hsa-mir-324-5p (MIRT043043)
- hsa-mir-92a-3p (MIRT049848)
- hsa-mir-4435 (MIRT452492)
- hsa-mir-6739-5p (MIRT452493)
- hsa-mir-6733-5p (MIRT452494)
- hsa-mir-3153 (MIRT452495)
- hsa-mir-766-5p (MIRT452496)
- hsa-mir-3202 (MIRT452497)
- hsa-mir-3179 (MIRT452498)
- hsa-mir-7113-5p (MIRT452499)
- hsa-mir-3677-5p (MIRT452500)
- hsa-mir-5584-5p (MIRT452501)
- hsa-mir-6876-5p (MIRT452502)
- hsa-mir-4476 (MIRT452503)
- hsa-mir-6891-5p (MIRT452504)
- hsa-mir-3173-3p (MIRT452505)
miRNA Products
- Search ViGene Biosciences for HMGXB3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HMGXB3
- Browse OriGene Inhibitory RNA Products For HMGXB3
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGXB3 gene
Clone Products
-
OriGene ORF clones in human for HMGXB3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Cell Line Products
-
Horizon Cell Lines for HMGXB3
-
ViGene Biosciences adenoviral particle packaged cDNA for HMGXB3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGXB3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGXB3 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HMGXB3 Gene
Localization for HMGXB3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMGXB3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for HMGXB3 Gene
No Data Available
Interacting Proteins for HMGXB3 Gene
Selected Interacting proteins:
Q12766-HMGX3_HUMAN
ENSP00000421917
for HMGXB3 Gene via
MINT
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
| GO:0016310 | phosphorylation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HMGXB3 Gene
Transcripts for HMGXB3 Gene
mRNA/cDNA for HMGXB3 Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HMGXB3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HMGXB3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGXB3
- GenScript: Design CRISPR guide RNA sequences for HMGXB3
miRNA Products
- Search ViGene Biosciences for HMGXB3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HMGXB3
- Browse OriGene Inhibitory RNA Products For HMGXB3
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGXB3 gene
Clone Products
-
OriGene ORF clones in human for HMGXB3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
| ExUns: | 20 |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: |
Expression for HMGXB3 Gene
This gene is overexpressed in Tlymphocyte (47.4) and Adipocyte (16.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMGXB3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HMGXB3 Gene:
HMGXB3SOURCE GeneReport for Unigene cluster for HMGXB3 Gene:
Hs.719189Evidence on tissue expression from TISSUES for HMGXB3 Gene
- Bone marrow(4.2)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for HMGXB3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGXB3 Gene
Orthologs for HMGXB3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMGXB3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HMGXB3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HMGXB3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hmgxb3 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HMGXB3 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-1413 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HMGXB3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HMGXB3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hmgxb3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101886434 34 |
|
||
| HMGXB3 35 |
|
OneToOne |
- Species where no ortholog for HMGXB3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HMGXB3 Gene
No data available for Paralogs for HMGXB3 Gene
Variants for HMGXB3 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs138905856 | Likely benign | 150,053,569(+) | CCTGT(A/G)AGATT | nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs150244467 | Likely benign | 150,053,465(+) | CCAAC(C/T)TTTAG | nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs367836988 | Likely benign | 150,053,538(+) | AAGGC(A/G)GCGTA | nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs371174880 | Likely benign | 150,053,295(+) | CTGAC(C/T)GCATT | nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs543445510 | Likely benign | 150,053,345(+) | GTGAC(-/TGTT)AGTTA | nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime |
Gene Damage Index Score:
6.48;
77.50% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HMGXB3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HMGXB3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGXB3 Gene
Disorders for HMGXB3 Gene
Relevant External Links for HMGXB3
No disorders were found for HMGXB3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMGXB3 Gene
Publications for HMGXB3 Gene
- Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 64
- Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J. … Goldstein D.B. (PLoS Genet. 2009) 3 46 64
- Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes. (PMID: 9027509) Andre C. … Galibert F. (Genomics 1997) 3 4 64
- A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3 64
- Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
Products for HMGXB3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HMGXB3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HMGXB3
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGXB3
- Origene Custom Protein Services for HMGXB3
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMGXB3
- Browse OriGene Inhibitory RNA Products For HMGXB3
- OriGene qPCR primer pairs for HMGXB3
- OriGene CRISPR knockouts for HMGXB3
- OriGene ORF clones in human for HMGXB3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HMGXB3
- GenScript: Next-day shipping cDNA ORF clone for HMGXB3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HMGXB3
- GenScript Custom Assay Services for HMGXB3
- GenScript Custom overexpressing Cell Line Services for HMGXB3
- GenScript: Design CRISPR guide RNA sequences for HMGXB3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HMGXB3
- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological qPCR Primers
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- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for HMGXB3
- ViGene Biosciences adenoviral particle packaged cDNA for HMGXB3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HMGXB3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HMGXB3 gene
- Search ViGene Biosciences for HMGXB3
- Horizon Cell Lines for HMGXB3
- Cyagen custom Knockout/knockin (KOKI) mouse models for HMGXB3
- VectorBuilder custom plasmid, inducible vectors for HMGXB3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMGXB3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HMGXB3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer