HMGXB3 Gene
protein-coding GIFtS: 39
GCID: GC05P149361
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|
HMG box domain containing 3
(Previous symbol: HMGX3)
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Aliases
for HMGXB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HMG Box Domain Containing 31 2 | | HMG Domain-Containing Protein 32 | | SMF1 2 3 | | HMG Box-Containing Protein 33 | | HMGX31 2 | | Protein SMF3 | | KIAA01941 3 | | |
Export aliases for HMGXB3 gene to outside databasesPrevious GC identifer: GC05P144528 |
Summaries
for HMGXB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HMGXB3:
This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domainfound in DNA binding proteins such as transcription factors and chromosomal proteins. (provided by RefSeq, Aug 2011)
|
Genomic Views
for HMGXB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HMGXB3 gene promoter:
AhR AML1a AP-2alpha isoform 2 AP-4 CUTL1 Evi-1 Arnt PPAR-alpha Sox9 AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for HMGXB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMGXB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q33.1HMGXB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P149361: view genomic region
(about GC identifiers)
Start:
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149,379,884 bp from pter |
End:
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149,432,706 bp from pter |
Size:
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52,823 bases |
Orientation:
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plus strand |
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Proteins
for HMGXB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HMGX3_HUMAN, Q12766 (See
protein sequence)Recommended Name: HMG domain-containing protein 3 Size: 1538 amino acids; 168334 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q86UG3 Q9UMF4Explore the universe of human proteins at neXtProt for HMGXB3: NX_Q12766
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q12766
HMGXB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055798.2
ENSEMBL proteins: ENSP00000422231 ENSP00000421917 ENSP00000426631
Human Recombinant Protein Products for HMGXB3:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HMGXB3 for ontologies About GeneDecksing
HMGXB3 Antibody Products:
Assay Products for HMGXB3: |
Protein
Domains /
Families
for HMGXB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HMGXB3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q12766ProtoNet protein and cluster: Q12766 UniProtKB/Swiss-Prot: HMGX3_HUMAN, Q12766Similarity: Contains 1 HMG box DNA-binding domain |
Function
for HMGXB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
HMGXB3 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMGXB3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMGXB3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HMGXB3 (NM_014983) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMGXB3 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HMGXB3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGXB3 |
|
Pathways & Interactions
for HMGXB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HMGXB3
5/8 Interacting proteins for HMGXB3 (Q127662, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
HMGXB3 for ontologies About GeneDecksing
|
Drugs & Compounds
for HMGXB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HMGXB3
Search CenterWatch for drugs/clinical trials and news about HMGXB3 / HMGX3
|
Transcripts
for HMGXB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HMGXB3 gene: NM_014983.2 Unigene Cluster for HMGXB3: HMG box domain containing 3 Hs.719189 [show with all ESTs]Unigene Representative Sequence: NM_0149835 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000503427(uc003lrk.4) ENST00000502717 ENST00000514469 ENST00000513318
ENST00000510472
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMGXB3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMGXB3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HMGXB3 (NM_014983) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMGXB3 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HMGXB3 |
Additional cDNA sequence: BC005880.2 BC035219.1 BC035434.1 BC051025.1 BC063691.1 BC092520.1 D83778.1 10 DOTS entries: DT.216158 DT.100814450 DT.100800218 DT.102824746 DT.100814453 DT.86841459 DT.100028188 DT.102824747 DT.75136268 DT.95093467
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for HMGXB3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 |
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| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for HMGXB3
|
Expression
for HMGXB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HMGXB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTAATTTA
About this image
See HMGXB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HMGXB3
SOURCE GeneReport for Unigene cluster: Hs.719189
SABiosciences Custom PCR Arrays for HMGXB3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMGXB3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HMGXB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMGXB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMGXB3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGXB3 |
Orthologs
for HMGXB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HMGXB3 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for HMGXB3 (if available)
TreeFam Gene Tree for HMGXB3 (if available) |
Paralogs
for HMGXB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HMGXB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HMGXB3 (149379884 - 149432706 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HMGXB3
1 CNV: 69220 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMGXB3 |
|
Disorders
/ Diseases
for HMGXB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for HMGXB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HMGXB3 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with HMGXB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2, 3 Nagase T.... Nomura N. (1996)
- Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes. (PubMed id 9027509)1, 2 Andre C.... Galibert F. (1997)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Common genetic variation and the control of HIV-1 in humans. (PubMed id 20041166)1 Fellay J....Goldstein D.B. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for HMGXB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HMGXB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HMGXB3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing HMGXB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HMGXB3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for HMGXB3 gene:
Search GeneIP for patents involving HMGXB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HMGXB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HMGXB3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMGXB3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMGXB3 | | | OriGene Protein Over-expression Lysate for HMGXB3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HMGXB3 | | OriGene 3'-UTR Clone for HMGXB3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMGXB3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMGXB3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HMGXB3 | | OriGene Custom Protein Services for HMGXB3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HMGXB3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMGXB3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMGXB3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMGXB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMGXB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMGXB3 |
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| | | | Search Tocris compounds for HMGXB3 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGXB3 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for HMGXB3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HMGXB3 |
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