Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HMGXB3 Gene

Aliases for HMGXB3 Gene

  • HMG-Box Containing 3 2 3 5
  • HMG Box Domain Containing 3 2 3
  • SMF 3 4
  • HMG Domain-Containing Protein 3 3
  • HMG Box-Containing Protein 3 4
  • Protein SMF 4
  • KIAA0194 4
  • HMGX3 3

External Ids for HMGXB3 Gene

Previous HGNC Symbols for HMGXB3 Gene

  • HMGX3

Previous GeneCards Identifiers for HMGXB3 Gene

  • GC05P149361
  • GC05P144528

Summaries for HMGXB3 Gene

Entrez Gene Summary for HMGXB3 Gene

  • This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. [provided by RefSeq, Aug 2011]

GeneCards Summary for HMGXB3 Gene

HMGXB3 (HMG-Box Containing 3) is a Protein Coding gene. GO annotations related to this gene include kinase activity.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGXB3 Gene

Genomics for HMGXB3 Gene

Regulatory Elements for HMGXB3 Gene

Enhancers for HMGXB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G149956 2 FANTOM5 Ensembl ENCODE dbSUPER 51.9 -40.4 -40397 6.7 HDGF PKNOX1 FOXA2 MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 ZBTB7B HMGXB3 ZNF300 ZNF300P1 RPL7P1 TIGD6 SLC26A2 RPS20P4 RPS14 PDGFRB SMIM3
GH05G150176 1.6 Ensembl ENCODE dbSUPER 43.9 +183.0 183012 12.8 HDGF ARNT ZFP64 ZNF2 YY1 FOS JUNB REST TBX21 ZNF592 ZNF300 ZNF300P1 HMGXB3 RPL7P1 RPS20P4 RPS14 PDGFRB SLC6A7 TIGD6 SMIM3
GH05G150581 1.6 Ensembl ENCODE dbSUPER 32.8 +584.1 584060 5.5 HDGF FOXA2 PKNOX1 CREB3L1 MLX ZFP64 SIN3A DMAP1 YY1 ZNF207 ZNF300 ZNF300P1 RPL7P1 HMGXB3 RPS14 RPS20P4 PDGFRB TIGD6 SMIM3 NDST1
GH05G150065 1.9 FANTOM5 Ensembl ENCODE dbSUPER 23 +66.3 66279 2.6 FOXA2 PKNOX1 CREB3L1 ARNT ARID4B ZNF766 FOS KLF13 SP3 SP5 HMGXB3 TIGD6 PCYOX1L CSF1R PDGFRB CDX1 PDE6A ENSG00000200334 TCOF1 CAMK2A
GH05G150496 1.7 Ensembl ENCODE dbSUPER 22.9 +508.0 508014 24.1 MLX ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 MEF2D RCOR2 NDST1 ZNF300 HMGXB3 ZNF300P1 NDST1-AS1 RPL7P1 RPS14 SYNPO ENSG00000253852 TIGD6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HMGXB3 on UCSC Golden Path with GeneCards custom track

Promoters for HMGXB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000188892 954 2401 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC

Genomic Location for HMGXB3 Gene

Chromosome:
5
Start:
150,000,046 bp from pter
End:
150,053,143 bp from pter
Size:
53,098 bases
Orientation:
Plus strand

Genomic View for HMGXB3 Gene

Genes around HMGXB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMGXB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMGXB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGXB3 Gene

Proteins for HMGXB3 Gene

  • Protein details for HMGXB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12766-HMGX3_HUMAN
    Recommended name:
    HMG domain-containing protein 3
    Protein Accession:
    Q12766
    Secondary Accessions:
    • G5E9Y4
    • Q86UG3
    • Q9UMF4

    Protein attributes for HMGXB3 Gene

    Size:
    1538 amino acids
    Molecular mass:
    168334 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HMGXB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMGXB3 Gene

Post-translational modifications for HMGXB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMGXB3 Gene

No data available for DME Specific Peptides for HMGXB3 Gene

Domains & Families for HMGXB3 Gene

Gene Families for HMGXB3 Gene

Protein Domains for HMGXB3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HMGXB3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HMGXB3: view

No data available for UniProtKB/Swiss-Prot for HMGXB3 Gene

Function for HMGXB3 Gene

Gene Ontology (GO) - Molecular Function for HMGXB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0016301 kinase activity NAS 9027509
genes like me logo Genes that share ontologies with HMGXB3: view

Phenotypes for HMGXB3 Gene

MGI mutant phenotypes for HMGXB3:
inferred from 1 alleles
GenomeRNAi human phenotypes for HMGXB3:
genes like me logo Genes that share phenotypes with HMGXB3: view

Animal Models for HMGXB3 Gene

MGI Knock Outs for HMGXB3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HMGXB3 Gene

Localization for HMGXB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGXB3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HMGXB3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HMGXB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HMGXB3: view

Pathways & Interactions for HMGXB3 Gene

SuperPathways for HMGXB3 Gene

No Data Available

Interacting Proteins for HMGXB3 Gene

Gene Ontology (GO) - Biological Process for HMGXB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with HMGXB3: view

No data available for Pathways by source and SIGNOR curated interactions for HMGXB3 Gene

Drugs & Compounds for HMGXB3 Gene

No Compound Related Data Available

Transcripts for HMGXB3 Gene

mRNA/cDNA for HMGXB3 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HMGXB3 Gene

HMG box domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMGXB3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4:
SP5:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for HMGXB3 Gene

GeneLoc Exon Structure for
HMGXB3
ECgene alternative splicing isoforms for
HMGXB3

Expression for HMGXB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HMGXB3 Gene

Protein differential expression in normal tissues from HIPED for HMGXB3 Gene

This gene is overexpressed in Tlymphocyte (47.4) and Adipocyte (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMGXB3 Gene



Protein tissue co-expression partners for HMGXB3 Gene

NURSA nuclear receptor signaling pathways regulating expression of HMGXB3 Gene:

HMGXB3

SOURCE GeneReport for Unigene cluster for HMGXB3 Gene:

Hs.719189

Evidence on tissue expression from TISSUES for HMGXB3 Gene

  • Bone marrow(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with HMGXB3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGXB3 Gene

Orthologs for HMGXB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMGXB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMGXB3 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia HMGXB3 34 35
  • 91.48 (n)
dog
(Canis familiaris)
Mammalia HMGXB3 34 35
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Hmgxb3 34 16 35
  • 87.73 (n)
oppossum
(Monodelphis domestica)
Mammalia HMGXB3 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-1413 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves HMGXB3 34 35
  • 71.68 (n)
lizard
(Anolis carolinensis)
Reptilia HMGXB3 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hmgxb3 34
  • 63.73 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101886434 34
  • 54.82 (n)
HMGXB3 35
  • 44 (a)
OneToOne
Species where no ortholog for HMGXB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMGXB3 Gene

ENSEMBL:
Gene Tree for HMGXB3 (if available)
TreeFam:
Gene Tree for HMGXB3 (if available)

Paralogs for HMGXB3 Gene

No data available for Paralogs for HMGXB3 Gene

Variants for HMGXB3 Gene

Sequence variations from dbSNP and Humsavar for HMGXB3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs138905856 Likely benign 150,053,569(+) CCTGT(A/G)AGATT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs150244467 Likely benign 150,053,465(+) CCAAC(C/T)TTTAG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs367836988 Likely benign 150,053,538(+) AAGGC(A/G)GCGTA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs371174880 Likely benign 150,053,295(+) CTGAC(C/T)GCATT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs543445510 Likely benign 150,053,345(+) GTGAC(-/TGTT)AGTTA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HMGXB3 Gene

Variant ID Type Subtype PubMed ID
esv24664 CNV gain+loss 19812545
nsv830518 CNV loss 17160897
nsv968262 CNV duplication 23825009

Variation tolerance for HMGXB3 Gene

Gene Damage Index Score: 6.48; 77.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HMGXB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HMGXB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGXB3 Gene

Disorders for HMGXB3 Gene

Relevant External Links for HMGXB3

Genetic Association Database (GAD)
HMGXB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HMGXB3

No disorders were found for HMGXB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMGXB3 Gene

Publications for HMGXB3 Gene

  1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 64
  2. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J. … Goldstein D.B. (PLoS Genet. 2009) 3 46 64
  3. Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes. (PMID: 9027509) Andre C. … Galibert F. (Genomics 1997) 3 4 64
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for HMGXB3 Gene

Sources for HMGXB3 Gene

Content
Loading form....