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Aliases for HMGXB3 Gene

Aliases for HMGXB3 Gene

  • HMG-Box Containing 3 2 3
  • HMG Box Domain Containing 3 2 3 5
  • SMF 3 4
  • HMG Box-Containing Protein 3 4
  • Protein SMF 4
  • KIAA0194 4
  • HMGX3 3

External Ids for HMGXB3 Gene

Previous HGNC Symbols for HMGXB3 Gene

  • HMGX3

Previous GeneCards Identifiers for HMGXB3 Gene

  • GC05P149361
  • GC05P144528

Summaries for HMGXB3 Gene

Entrez Gene Summary for HMGXB3 Gene

  • This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. [provided by RefSeq, Aug 2011]

GeneCards Summary for HMGXB3 Gene

HMGXB3 (HMG-Box Containing 3) is a Protein Coding gene. GO annotations related to this gene include kinase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGXB3 Gene

Genomics for HMGXB3 Gene

Regulatory Elements for HMGXB3 Gene

Enhancers for HMGXB3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HMGXB3 on UCSC Golden Path with GeneCards custom track

Promoters for HMGXB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HMGXB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HMGXB3 Gene

150,000,046 bp from pter
150,053,143 bp from pter
53,098 bases
Plus strand

Genomic View for HMGXB3 Gene

Genes around HMGXB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMGXB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMGXB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGXB3 Gene

Proteins for HMGXB3 Gene

  • Protein details for HMGXB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HMG domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • G5E9Y4
    • Q86UG3
    • Q9UMF4

    Protein attributes for HMGXB3 Gene

    1538 amino acids
    Molecular mass:
    168334 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HMGXB3 Gene


neXtProt entry for HMGXB3 Gene

Proteomics data for HMGXB3 Gene at MOPED

Post-translational modifications for HMGXB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMGXB3 Gene

No data available for DME Specific Peptides for HMGXB3 Gene

Domains & Families for HMGXB3 Gene

Gene Families for HMGXB3 Gene

Protein Domains for HMGXB3 Gene


Suggested Antigen Peptide Sequences for HMGXB3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 HMG box DNA-binding domain.
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with HMGXB3: view

Function for HMGXB3 Gene

Phenotypes for HMGXB3 Gene

GenomeRNAi human phenotypes for HMGXB3:
genes like me logo Genes that share phenotypes with HMGXB3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMGXB3 Gene

Localization for HMGXB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGXB3 Gene

Subcellular locations from

Jensen Localization Image for HMGXB3 Gene COMPARTMENTS Subcellular localization image for HMGXB3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HMGXB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with HMGXB3: view

Pathways & Interactions for HMGXB3 Gene

SuperPathways for HMGXB3 Gene

No Data Available

Interacting Proteins for HMGXB3 Gene

Gene Ontology (GO) - Biological Process for HMGXB3 Gene


No data available for Pathways by source and SIGNOR curated interactions for HMGXB3 Gene

Drugs & Compounds for HMGXB3 Gene

No Compound Related Data Available

Transcripts for HMGXB3 Gene

mRNA/cDNA for HMGXB3 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HMGXB3 Gene

HMG box domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMGXB3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^
SP1: - - -
SP2: - - - - -
SP3: - - -

ExUns: 20

Relevant External Links for HMGXB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HMGXB3 Gene

mRNA expression in normal human tissues for HMGXB3 Gene

Protein differential expression in normal tissues from HIPED for HMGXB3 Gene

This gene is overexpressed in Tlymphocyte (47.4) and Adipocyte (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HMGXB3 Gene

SOURCE GeneReport for Unigene cluster for HMGXB3 Gene Hs.719189

genes like me logo Genes that share expression patterns with HMGXB3: view

Protein tissue co-expression partners for HMGXB3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HMGXB3 Gene

Orthologs for HMGXB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMGXB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HMGXB3 35
  • 91.48 (n)
  • 92.92 (a)
  • 82 (a)
(Canis familiaris)
Mammalia HMGXB3 35
  • 91.41 (n)
  • 93.1 (a)
  • 93 (a)
(Mus musculus)
Mammalia Hmgxb3 35
  • 87.73 (n)
  • 89.36 (a)
Hmgxb3 16
Hmgxb3 36
  • 89 (a)
(Pan troglodytes)
Mammalia HMGXB3 35
  • 99.74 (n)
  • 99.69 (a)
  • 100 (a)
(Monodelphis domestica)
Mammalia HMGXB3 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-1413 36
  • 74 (a)
(Gallus gallus)
Aves HMGXB3 35
  • 71.68 (n)
  • 72.83 (a)
  • 68 (a)
(Anolis carolinensis)
Reptilia HMGXB3 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hmgxb3 35
  • 63.73 (n)
  • 61.61 (a)
(Danio rerio)
Actinopterygii LOC101886434 35
  • 54.82 (n)
  • 47.97 (a)
  • 44 (a)
Species with no ortholog for HMGXB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMGXB3 Gene

Gene Tree for HMGXB3 (if available)
Gene Tree for HMGXB3 (if available)

Paralogs for HMGXB3 Gene

No data available for Paralogs for HMGXB3 Gene

Variants for HMGXB3 Gene

Sequence variations from dbSNP and Humsavar for HMGXB3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs714099 -- 150,034,096(-) TCCTT(A/G)AAACT intron-variant
rs966564 -- 150,021,406(+) CTCAG(G/T)CATTG intron-variant
rs1062028 -- 150,051,934(+) TCCAT(A/C/T)GTGGA reference, synonymous-codon
rs3020829 -- 150,047,403(-) CTGCA(C/T)ACCGC intron-variant
rs216125 -- 150,048,832(+) ACCCC(C/G/T)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMGXB3 Gene

Variant ID Type Subtype PubMed ID
esv24664 CNV Gain+Loss 19812545
nsv830518 CNV Loss 17160897

Variation tolerance for HMGXB3 Gene

Gene Damage Index Score: 6.48; 77.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HMGXB3 Gene

Disorders for HMGXB3 Gene

Relevant External Links for HMGXB3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HMGXB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMGXB3 Gene

Publications for HMGXB3 Gene

  1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 67
  2. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  3. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J. … Goldstein D.B. (PLoS Genet. 2009) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Sequence analysis of the equine SLC26A2 gene locus on chromosome 14q15-->q21. (PMID: 17901700) Hansen M. … Brenig B. (Cytogenet. Genome Res. 2007) 23

Products for HMGXB3 Gene

Sources for HMGXB3 Gene