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Aliases for HMGN5 Gene

Aliases for HMGN5 Gene

  • High Mobility Group Nucleosome Binding Domain 5 2 3
  • NSBP1 3 4 6
  • High-Mobility Group Nucleosome Binding Domain 5 2 3
  • Nucleosomal Binding Protein 1 2 3
  • Nucleosome-Binding Protein 1 3 4
  • High Mobility Group Nucleosome-Binding Domain-Containing Protein 5 3
  • NBP-45 3

External Ids for HMGN5 Gene

Previous Symbols for HMGN5 Gene

  • NSBP1

Summaries for HMGN5 Gene

Entrez Gene Summary for HMGN5 Gene

  • This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009]

GeneCards Summary for HMGN5 Gene

HMGN5 (High Mobility Group Nucleosome Binding Domain 5) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and nucleosomal DNA binding.

UniProtKB/Swiss-Prot for HMGN5 Gene

  • Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGN5 Gene

Genomics for HMGN5 Gene

Genomic Location for HMGN5 Gene

81,113,701 bp from pter
81,201,942 bp from pter
88,242 bases
Minus strand

Genomic View for HMGN5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMGN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGN5 Gene

No data available for Regulatory Elements for HMGN5 Gene

Proteins for HMGN5 Gene

  • Protein details for HMGN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    High mobility group nucleosome-binding domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • Q5JSL1

    Protein attributes for HMGN5 Gene

    282 amino acids
    Molecular mass:
    31525 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK094058; Type=Frameshift; Positions=132; Evidence={ECO:0000305};

neXtProt entry for HMGN5 Gene

Proteomics data for HMGN5 Gene at MOPED

Post-translational modifications for HMGN5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMGN5 Gene

No data available for DME Specific Peptides for HMGN5 Gene

Domains for HMGN5 Gene

Gene Families for HMGN5 Gene

  • HMG :High-mobility group / Canonical

Protein Domains for HMGN5 Gene

Suggested Antigen Peptide Sequences for HMGN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Specifically targeted by its C-terminus to nucleosomes in euchromatin.:
    • P82970
  • Belongs to the HMGN family.:
    • P82970
genes like me logo Genes that share domains with HMGN5: view

Function for HMGN5 Gene

Molecular function for HMGN5 Gene

UniProtKB/Swiss-Prot Function: Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.

Gene Ontology (GO) - Molecular Function for HMGN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding NAS 11161810
GO:0031492 nucleosomal DNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with HMGN5: view

Phenotypes for HMGN5 Gene

MGI mutant phenotypes for HMGN5:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with HMGN5: view

Animal Models for HMGN5 Gene

MGI Knock Outs for HMGN5:

miRNA for HMGN5 Gene

miRTarBase miRNAs that target HMGN5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HMGN5 Gene

Localization for HMGN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGN5 Gene

Nucleus. Note=Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for HMGN5 Gene COMPARTMENTS Subcellular localization image for HMGN5 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HMGN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus NAS 11161810
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with HMGN5: view

Pathways for HMGN5 Gene

SuperPathways for HMGN5 Gene

No Data Available

Interacting Proteins for HMGN5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000350848 for HMGN5 Gene via STRING

Gene Ontology (GO) - Biological Process for HMGN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 11161810
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0008284 positive regulation of cell proliferation IMP 20531280
GO:0010628 positive regulation of gene expression IMP 20531280
genes like me logo Genes that share ontologies with HMGN5: view

No data available for Pathways by source for HMGN5 Gene

Transcripts for HMGN5 Gene

Unigene Clusters for HMGN5 Gene

High mobility group nucleosome binding domain 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMGN5 Gene

No ASD Table

Relevant External Links for HMGN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HMGN5 Gene

mRNA expression in normal human tissues for HMGN5 Gene

mRNA differential expression in normal tissues according to GTEx for HMGN5 Gene

This gene is overexpressed in Testis (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMGN5 Gene

SOURCE GeneReport for Unigene cluster for HMGN5 Gene Hs.282204

mRNA Expression by UniProt/SwissProt for HMGN5 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with HMGN5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HMGN5 Gene

Orthologs for HMGN5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for HMGN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HMGN5 35
  • 97.7 (n)
  • 96 (a)
HMGN5 36
  • 95 (a)
(Bos Taurus)
Mammalia HMGN5 35
  • 85.56 (n)
  • 70 (a)
HMGN5 36
  • 66 (a)
(Canis familiaris)
Mammalia HMGN5 36
  • 49 (a)
(Mus musculus)
Mammalia Hmgn5 16
Hmgn5 36
  • 35 (a)
Species with no ortholog for HMGN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HMGN5 Gene

Gene Tree for HMGN5 (if available)
Gene Tree for HMGN5 (if available)

Paralogs for HMGN5 Gene

Selected SIMAP similar genes for HMGN5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HMGN5: view

No data available for Paralogs for HMGN5 Gene

Variants for HMGN5 Gene

Sequence variations from dbSNP and Humsavar for HMGN5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1937289 -- 81,115,947(-) ATAAC(A/G)ACCTT intron-variant
rs1937290 -- 81,113,611(-) cAGCA(A/G)GTCTC downstream-variant-500B
rs1937291 -- 81,113,451(-) tttta(A/G)gttaa downstream-variant-500B
rs1937292 -- 81,113,351(-) gtcta(A/G)gatgg downstream-variant-500B
rs1954611 -- 81,122,821(+) TAAAG(G/T)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMGN5 Gene

Variant ID Type Subtype PubMed ID
esv33127 CNV Loss 17666407
esv2671958 CNV Deletion 23128226
esv24043 CNV Loss 19812545
esv271671 CNV Insertion 20981092

Relevant External Links for HMGN5 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGN5 Gene

Disorders for HMGN5 Gene

No disorders were found for HMGN5 Gene.

No data available for UniProtKB/Swiss-Prot for HMGN5 Gene

Publications for HMGN5 Gene

  1. Characterization of a human gene encoding nucleosomal binding protein NSBP1. (PMID: 11161810) King L.M. … Francomano C.A. (Genomics 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4
  5. The interaction of NSBP1/HMGN5 with nucleosomes in euchromatin counteracts linker histone-mediated chromatin compaction and modulates transcription. (PMID: 19748358) Rochman M. … Bustin M. (Mol. Cell 2009) 2 3

Products for HMGN5 Gene

Sources for HMGN5 Gene

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