HMGN5 Gene
protein-coding GIFtS: 46
GCID: GC0XM080370
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high mobility group nucleosome binding domain 5(Previous names: nucleosomal binding protein 1, high-mobility group nucleosome...)
(Previous symbol: NSBP1)
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Aliases
for HMGN5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| High Mobility Group Nucleosome Binding Domain 51 2 | | Nucleosome-Binding Protein 12 3 | | NSBP11 2 3 5 | | NBP-452 | | High-Mobility Group Nucleosome Binding Domain 51 2 | | High Mobility Group Nucleosome-Binding Domain-Containing Protein 52 | | Nucleosomal Binding Protein 11 2 | | |
Export aliases for HMGN5 gene to outside databasesPrevious GC identifers: GC0XM080255 GC0XM073949 |
Summaries
for HMGN5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HMGN5:
This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, whichsuggests that this protein may function as a nucleosomal binding and transcriptional activating protein. (provided byRefSeq, Sep 2009)
UniProtKB/Swiss-Prot: HMGN5_HUMAN, P82970Function: Preferentially binds to euchromatin and modulates cellular transcription by counteracting linkerhistone-mediated chromatin compaction (By similarity)
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Genomic Views
for HMGN5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for HMGN5
Other transcription factors
Search SABiosciences Chromatin IP Primers for HMGN5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMGN5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.3 Ensembl cytogenetic band: Xq21.1 HGNC cytogenetic band: Xq13.3HMGN5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM080370: view genomic region
(about GC identifiers)
Start:
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80,369,200 bp from pter |
End:
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80,457,441 bp from pter |
Size:
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88,242 bases |
Orientation:
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minus strand |
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Proteins
for HMGN5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HMGN5_HUMAN, P82970 (See
protein sequence)Recommended Name: High mobility group nucleosome-binding domain-containing protein 5 Size: 282 amino acids; 31525 Da
Subcellular location: Nucleus. Note=Associates with nucleosomes in euchromatin and is largely excluded fromconstitutive heterochromatin (By similarity)
Sequence caution: Sequence=AK094058; Type=Frameshift; Positions=132;
Secondary accessions: Q5JSL1Explore the universe of human proteins at neXtProt for HMGN5: NX_P82970
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P82970
HMGN5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_110390.1
ENSEMBL proteins: ENSP00000350848 ENSP00000408060 ENSP00000362347 ENSP00000399626 ENSP00000413402 ENSP00000404810
Human Recombinant Protein Products for HMGN5:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
HMGN5 for ontologies About GeneDecksing
HMGN5 Antibody Products:
Assay Products for HMGN5: |
Protein
Domains /
Families
for HMGN5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HMGN5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P82970ProtoNet protein and cluster: P82970 1 Blocks protein family: IPB000079 High mobility group protein HMG14 and HMG17
UniProtKB/Swiss-Prot: HMGN5_HUMAN, P82970Domain: Specifically targeted by its C-terminus to nucleosomes in euchromatin (By similarity)Similarity: Belongs to the HMGN family |
Function
for HMGN5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: HMGN5_HUMAN, P82970Function: Preferentially binds to euchromatin and modulates cellular transcription by counteracting linkerhistone-mediated chromatin compaction (By similarity) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
HMGN5 for ontologies About GeneDecksing
Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Hmgn5):
HMGN5 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Hmgn5tm1Mbus for HMGN5
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMGN5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMGN5 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: HMGN5 (NM_030763) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGN5 |
|
Pathways & Interactions
for HMGN5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HMGN5
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for HMGN5 (ENSP000003508484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | 11161810 | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0016568 | chromatin modification |
IEA | -- | | GO:0045893 | positive regulation of transcription, DNA-dependent |
NAS | 11161810 |
HMGN5 for ontologies About GeneDecksing
|
Drugs & Compounds
for HMGN5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HMGN5
Search CenterWatch for drugs/clinical trials and news about HMGN5
|
Transcripts
for HMGN5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HMGN5 gene: NM_030763.2 Unigene Cluster for HMGN5: High mobility group nucleosome binding domain 5 Hs.282204 [show with all ESTs]Unigene Representative Sequence: NM_0307637 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000358130(uc004eee.1) ENST00000447319 ENST00000373250 ENST00000430960
ENST00000491275 ENST00000436386 ENST00000451455
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMGN5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMGN5 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HMGN5 (NM_030763) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMGN5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGN5 |
Additional cDNA sequence: AF250329.1 AK094058.1 AK315792.1 BC005342.1 10 DOTS entries: DT.80101740 DT.99956343 DT.40122685 DT.95157733 DT.95210672 DT.97842370 DT.91749233 DT.95157739 DT.100751758 DT.95157735 24/62 AceView cDNA sequences (see all 62): AF250329 BM761606 AW269166 NM_030763 BX280399 BQ432332 BQ232754 CR602524 BQ440464 BM977068 BX348667 BQ438410 BP370210 BQ432883 BQ438411 BP369740 BP371008 BX332208 AX748432 AA669885 CB160129 BQ429736 CA867236 CA942534
GeneLoc Exon Structure
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Expression
for HMGN5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HMGN5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATGTTAAG
About this image
See HMGN5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HMGN5
SOURCE GeneReport for Unigene cluster: Hs.282204
UniProtKB/Swiss-Prot: HMGN5_HUMAN, P82970Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for HMGN5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMGN5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HMGN5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMGN5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMGN5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGN5 |
Orthologs
for HMGN5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HMGN5 gene from 2/11 species (see all 11) About this table
ENSEMBL Gene Tree for HMGN5 (if available)
TreeFam Gene Tree for HMGN5 (if available) |
Paralogs
for HMGN5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HMGN5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HMGN5 (80369200 - 80457441 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for HMGN5
1 CNV: 7799
4 Indels: 74018 83612 96786 96787
Locus Specific Mutation Databases (LSDB): HMGN5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMGN5 |
|
Disorders
/ Diseases
for HMGN5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HMGN5 for disorders About GeneDecksing
OMIM gene information: 300385
OMIM disorders: --
6  diseases for HMGN5: About MalaCardsconjunctivitis prostate carcinoma prostatitis prostate cancer
carcinoma malaria
Export disorders for HMGN5 gene to outside databases
|
Publications
for HMGN5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HMGN5 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with HMGN5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a human gene encoding nucleosomal binding protein NSBP1. (PubMed id 11161810)1, 2, 3 King L.M. and Francomano C.A. (2001)
- The interaction of NSBP1/HMGN5 with nucleosomes in eu chromatin counteracts linker histone-mediated chromatin compaction and modulate s transcription. (PubMed id 19748358)1, 3 Rochman M....Bustin M. (2009)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Small interfering RNA targeting HMGN5 induces apoptosi s via modulation of a mitochondrial pathway and Bcl-2 family proteins in prostat e cancer cells. (PubMed id 22504871)1 Zhang X.Y....Zhou L.Q. (2012)
- Knockdown of the nucleosome binding protein 1 inhibits the growth and invasion of clear cell renal cell carcinoma cells in vitro and i n vivo. (PubMed id 22420896)1 Ji S.Q....Zhou L.Q. (2012)
- Distinct properties of human HMGN5 reveal a rapidly e volving but functionally conserved nucleosome binding protein. (PubMed id 21518955)1 Malicet C....Bustin M. (2011)
- HMGN5: a potential oncogene in gliomas. (PubMed id 21373965)1 Qu J....Lu Y. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for HMGN5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HMGN5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HMGN5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HMGN5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HMGN5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HMGN5 gene:
Search GeneIP for patents involving HMGN5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HMGN5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HMGN5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMGN5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMGN5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HMGN5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMGN5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMGN5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGN5 |
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