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Aliases for HMGN5 Gene

Aliases for HMGN5 Gene

  • High Mobility Group Nucleosome Binding Domain 5 2 3 5
  • High-Mobility Group Nucleosome Binding Domain 5 2 3
  • Nucleosomal Binding Protein 1 2 3
  • Nucleosome-Binding Protein 1 3 4
  • NSBP1 3 4
  • NBP-45 3

External Ids for HMGN5 Gene

Previous HGNC Symbols for HMGN5 Gene

  • NSBP1

Previous GeneCards Identifiers for HMGN5 Gene

  • GC0XM080255
  • GC0XM080370
  • GC0XM073949

Summaries for HMGN5 Gene

Entrez Gene Summary for HMGN5 Gene

  • This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009]

GeneCards Summary for HMGN5 Gene

HMGN5 (High Mobility Group Nucleosome Binding Domain 5) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and nucleosomal DNA binding.

UniProtKB/Swiss-Prot for HMGN5 Gene

  • Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGN5 Gene

Genomics for HMGN5 Gene

Regulatory Elements for HMGN5 Gene

Promoters for HMGN5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HMGN5 on UCSC Golden Path with GeneCards custom track

Genomic Location for HMGN5 Gene

Chromosome:
X
Start:
81,113,701 bp from pter
End:
81,201,942 bp from pter
Size:
88,242 bases
Orientation:
Minus strand

Genomic View for HMGN5 Gene

Genes around HMGN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMGN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMGN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGN5 Gene

Proteins for HMGN5 Gene

  • Protein details for HMGN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82970-HMGN5_HUMAN
    Recommended name:
    High mobility group nucleosome-binding domain-containing protein 5
    Protein Accession:
    P82970
    Secondary Accessions:
    • Q5JSL1

    Protein attributes for HMGN5 Gene

    Size:
    282 amino acids
    Molecular mass:
    31525 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK094058; Type=Frameshift; Positions=132; Evidence={ECO:0000305};

neXtProt entry for HMGN5 Gene

Proteomics data for HMGN5 Gene at MOPED

Post-translational modifications for HMGN5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMGN5 Gene

No data available for DME Specific Peptides for HMGN5 Gene

Domains & Families for HMGN5 Gene

Gene Families for HMGN5 Gene

Protein Domains for HMGN5 Gene

Suggested Antigen Peptide Sequences for HMGN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P82970

UniProtKB/Swiss-Prot:

HMGN5_HUMAN :
  • Specifically targeted by its C-terminus to nucleosomes in euchromatin.
  • Belongs to the HMGN family.
Domain:
  • Specifically targeted by its C-terminus to nucleosomes in euchromatin.
Family:
  • Belongs to the HMGN family.
genes like me logo Genes that share domains with HMGN5: view

Function for HMGN5 Gene

Molecular function for HMGN5 Gene

UniProtKB/Swiss-Prot Function:
Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.

Gene Ontology (GO) - Molecular Function for HMGN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA,NAS 11161810
genes like me logo Genes that share ontologies with HMGN5: view

Phenotypes for HMGN5 Gene

GenomeRNAi human phenotypes for HMGN5:
genes like me logo Genes that share phenotypes with HMGN5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMGN5 Gene

Localization for HMGN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGN5 Gene

Nucleus. Note=Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMGN5 Gene COMPARTMENTS Subcellular localization image for HMGN5 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HMGN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with HMGN5: view

Pathways & Interactions for HMGN5 Gene

SuperPathways for HMGN5 Gene

No Data Available

Interacting Proteins for HMGN5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000350848%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000405965%0d%0a
Selected Interacting proteins: ENSP00000350848 for HMGN5 Gene via STRING

Gene Ontology (GO) - Biological Process for HMGN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 11161810
GO:0010628 positive regulation of gene expression IMP 20531280
GO:0043066 negative regulation of apoptotic process IMP 20531280
genes like me logo Genes that share ontologies with HMGN5: view

No data available for Pathways by source and SIGNOR curated interactions for HMGN5 Gene

Drugs & Compounds for HMGN5 Gene

No Compound Related Data Available

Transcripts for HMGN5 Gene

Unigene Clusters for HMGN5 Gene

High mobility group nucleosome binding domain 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMGN5 Gene

No ASD Table

Relevant External Links for HMGN5 Gene

GeneLoc Exon Structure for
HMGN5
ECgene alternative splicing isoforms for
HMGN5

Expression for HMGN5 Gene

mRNA expression in normal human tissues for HMGN5 Gene

mRNA differential expression in normal tissues according to GTEx for HMGN5 Gene

This gene is overexpressed in Testis (x6.0).

Protein differential expression in normal tissues from HIPED for HMGN5 Gene

This gene is overexpressed in Liver (16.1), Nasal epithelium (12.2), and Testis (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HMGN5 Gene



SOURCE GeneReport for Unigene cluster for HMGN5 Gene Hs.282204

mRNA Expression by UniProt/SwissProt for HMGN5 Gene

P82970-HMGN5_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with HMGN5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for HMGN5 Gene

Orthologs for HMGN5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for HMGN5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HMGN5 35
  • 85.56 (n)
  • 70 (a)
HMGN5 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HMGN5 35
  • 97.7 (n)
  • 96 (a)
HMGN5 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMGN5 36
  • 49 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmgn5 36
  • 35 (a)
OneToOne
Species with no ortholog for HMGN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HMGN5 Gene

ENSEMBL:
Gene Tree for HMGN5 (if available)
TreeFam:
Gene Tree for HMGN5 (if available)

Paralogs for HMGN5 Gene

(2) SIMAP similar genes for HMGN5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HMGN5: view

No data available for Paralogs for HMGN5 Gene

Variants for HMGN5 Gene

Sequence variations from dbSNP and Humsavar for HMGN5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1937289 -- 81,115,947(-) ATAAC(A/G)ACCTT intron-variant
rs1937290 -- 81,113,611(-) cAGCA(A/G)GTCTC downstream-variant-500B
rs1937291 -- 81,113,451(+) tttta(A/C/G/T)gttaa downstream-variant-500B
rs1937292 -- 81,113,351(-) gtcta(A/G)gatgg downstream-variant-500B
rs1954611 -- 81,122,821(+) TAAAG(G/T)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMGN5 Gene

Variant ID Type Subtype PubMed ID
esv33127 CNV Loss 17666407
esv2671958 CNV Deletion 23128226
esv24043 CNV Loss 19812545
esv271671 CNV Insertion 20981092

Variation tolerance for HMGN5 Gene

Gene Damage Index Score: 2.46; 43.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HMGN5 Gene

HapMap Linkage Disequilibrium report
HMGN5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGN5 Gene

Disorders for HMGN5 Gene

Relevant External Links for HMGN5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HMGN5

No disorders were found for HMGN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMGN5 Gene

Publications for HMGN5 Gene

  1. Characterization of a human gene encoding nucleosomal binding protein NSBP1. (PMID: 11161810) King L.M. … Francomano C.A. (Genomics 2001) 2 3 4 67
  2. The interaction of NSBP1/HMGN5 with nucleosomes in euchromatin counteracts linker histone-mediated chromatin compaction and modulates transcription. (PMID: 19748358) Rochman M. … Bustin M. (Mol. Cell 2009) 2 3
  3. HMGN5 knockdown sensitizes prostate cancer cells to ionizing radiation. (PMID: 25307178) Su B. … Zhou L. (Prostate 2015) 3
  4. The high-mobility group nucleosome-binding domain 5 is highly expressed in breast cancer and promotes the proliferation and invasion of breast cancer cells. (PMID: 25315189) Weng M. … Xu J. (Tumour Biol. 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for HMGN5 Gene

Sources for HMGN5 Gene

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