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HMGN4 Gene

protein-coding   GIFtS: 50
GCID: GC06P026538

High Mobility Group Nucleosomal Binding Domain 4

(Previous name: high-mobility group (nonhistone chromosomal) protein 17-like...)
(Previous symbol: HMG17L3)
  Search for HMGN4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
High Mobility Group Nucleosomal Binding Domain 41 2     High Mobility Group Nucleosome-Binding Domain-Containing Protein 42
HMG17L31 2 3     High Mobility Group Protein N42
High-Mobility Group (Nonhistone Chromosomal) Protein 17-Like 31 2     High-Mobility Group Protein 17-Like 32
Non-Histone Chromosomal Protein HMG-17-Like 32 3     Non-Histone Chromosomal Protein3
NHC2 3     

External Ids:    HGNC: 49891   Entrez Gene: 104732   Ensembl: ENSG000001829527   UniProtKB: O004793   

Export aliases for HMGN4 gene to outside databases

Previous GC identifers: GC06P026602 GC06P026646 GC06P026481


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HMGN4 Gene:
The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the
chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. (provided by RefSeq,
Mar 2013)

GeneCards Summary for HMGN4 Gene:
HMGN4 (high mobility group nucleosomal binding domain 4) is a protein-coding gene. GO annotations related to this gene include nucleosomal DNA binding. An important paralog of this gene is HMGN2.

Gene Wiki entry for HMGN4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HMGN4 gene promoter:
         STAT1   STAT4   STAT2   STAT3   STAT1beta   STAT5A   HNF-3beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHMGN4 promoter sequence
   Search Chromatin IP Primers for HMGN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMGN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p21.3

HMGN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMGN4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026538:  view genomic region     (about GC identifiers)

Start:
26,538,572 bp from pter      End:
26,547,165 bp from pter
Size:
8,594 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HMGN4_HUMAN, O00479 (See protein sequence)
Recommended Name: High mobility group nucleosome-binding domain-containing protein 4  
Size: 90 amino acids; 9539 Da
Secondary accessions: B2R4I6 Q53XL9

Explore the universe of human proteins at neXtProt for HMGN4: NX_O00479

Explore proteomics data for HMGN4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HMGN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006344.1  
    ENSEMBL proteins: 
     ENSP00000366798  

    HMGN4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HMGN4

     
    Search eBioscience for Proteins for HMGN4 

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    ThermoFisher Antibodies for HMGN4
    LSBio Antibodies in human, mouse, rat for HMGN4

    HMGN4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for HMGN4
    Cloud-Clone Corp. CLIAs for HMGN4
    Search eBioscience for ELISAs for HMGN4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HMG: High-mobility group / Canonical

    1 InterPro protein domain:
     IPR000079 HMGN_fam

    Graphical View of Domain Structure for InterPro Entry O00479

    ProtoNet protein and cluster: O00479

    1 Blocks protein domain: IPB000079 High mobility group protein HMG14 and HMG17

    UniProtKB/Swiss-Prot: HMGN4_HUMAN, O00479
    Similarity: Belongs to the HMGN family


    Find genes that share domains with HMGN4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031492nucleosomal DNA binding IEA--
         
    Find genes that share ontologies with HMGN4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HMGN4:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HMGN4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HMGN4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HMGN4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HMGN4

    miRNA
    Products:
        
    miRTarBase miRNAs that target HMGN4:
    hsa-mir-615-3p (MIRT039769), hsa-mir-505-3p (MIRT041040), hsa-mir-7-5p (MIRT025702), hsa-mir-124-3p (MIRT022292)

    Block miRNA regulation of human, mouse, rat HMGN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HMGN4 (see all 9):
    hsa-miR-3163 hsa-miR-548e hsa-miR-548o hsa-miR-340 hsa-miR-3692 hsa-miR-548a-3p hsa-miR-1323 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidHMGN4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HMGN4
    Predesigned siRNA for gene silencing in human, mouse, rat HMGN4

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HMGN4 (NM_006353)
    Sino Biological Human cDNA Clone for HMGN4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMGN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGN4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HMGN4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGN4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HMGN4_HUMAN, O00479: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005634nucleus IEA--

    Find genes that share ontologies with HMGN4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HMGN4
    Interactions:

        Search GeneGlobe Interaction Network for HMGN4

    1 Interacting protein for HMGN4 (O004793) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EWSR1Q018443I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HMGN4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HMGN4 gene: 
    NM_006353.2  

    Unigene Cluster for HMGN4:

    High mobility group nucleosomal binding domain 4
    Hs.236774  [show with all ESTs]
    Unigene Representative Sequence: NM_006353
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377575 ENST00000477243
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HMGN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HMGN4 (see all 9):
    hsa-miR-3163 hsa-miR-548e hsa-miR-548o hsa-miR-340 hsa-miR-3692 hsa-miR-548a-3p hsa-miR-1323 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidHMGN4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HMGN4
    Predesigned siRNA for gene silencing in human, mouse, rat HMGN4
    Clone
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    OriGene clones in human, mouse for HMGN4 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HMGN4 (NM_006353)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMGN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGN4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HMGN4
    OriGene qSTAR qPCR primer pairs in human, mouse for HMGN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HMGN4
      QuantiTect SYBR Green Assays in human, mouse, rat HMGN4
      QuantiFast Probe-based Assays in human, mouse, rat HMGN4

    Additional mRNA sequence: 

    AK311841.1 BC001282.1 BC035998.1 BT009824.1 

    7 DOTS entries:

    DT.75139983  DT.100823375  DT.100823379  DT.92443710  DT.95136662  DT.100823378  DT.91945958 

    Selected AceView cDNA sequences (see all 359):

    AW470025 BM909445 AA865845 CR613004 AA828479 NM_006353 CA412884 CA405940 
    BM313743 F30862 CB121612 AA487257 CR621282 AA707270 BM460217 BF516055 
    AA487374 BM693092 CR601032 AI910534 AA487320 AI340948 N53390 BU629570 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HMGN4    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
    SP1:                          -           -                                       
    SP2:                          -     -                                             
    SP3:                          -     -     -                                       
    SP4:                                -                                             
    SP5:                          -     -     -     -                                 


    ECgene alternative splicing isoforms for HMGN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HMGN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATATGGTAC
    HMGN4 Expression
    About this image

    HMGN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMGN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.236774
        Custom PCR Arrays for HMGN4
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    QuantiFast Probe-based Assays in human, mouse, rat HMGN4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HMGN4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmgn2l65 high-mobility group nucleosomal binding domain 2-like more   --   X (62.61 cM) 141870135 
    chicken
    (Gallus gallus)
    Aves HMGN26
    Gallus gallus high mobility group nucleosomal bind...
    83(a)
    1 ↔ 1
    23(155931-159391)
    lizard
    (Anolis carolinensis)
    Reptilia HMGN46
    high mobility group nucleosomal binding domain 4
    82(a)
    1 ↔ 1
    GL343480.1(638060-642947)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hmgn21 high mobility group nucleosomal binding domain 2 71.11(n)
    73.33(a)
      496440  NM_001011031.2  NP_001011031.1 


    ENSEMBL Gene Tree for HMGN4 (if available)
    TreeFam Gene Tree for HMGN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HMGN4 gene
    HMGN22  
    1 SIMAP similar gene for HMGN4 using alignment to 1 protein entry:     HMGN4_HUMAN:
    HMGN2

    Find genes that share paralogs with HMGN4           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for HMGN4
    PGOHUM00000258931 PGOHUM00000259817


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HMGN4 (see all 215)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429856371,2
    C--26536638(+) CGGCT-/GGG   
       GGGGG
    GTTGA
    1 -- us2k10--------
    rs94677791,2
    C,F,A,H--26536687(+) AGTGTT/ATATTC 1 -- us2k131Minor allele frequency- A:0.45NS EA NA WA CSA 2901
    rs737384811,2
    C,F--26536775(+) TTCTCC/AGAAAT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1929231951,2
    --26536782(+) AAATAC/TGGACA 1 -- us2k10--------
    rs799619701,2
    C,F--26536804(+) ACACAT/CATGAG 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1841457151,2
    --26536807(+) CATATG/TAGACG 1 -- us2k10--------
    rs121114961,2
    C,F,H--26536886(+) AGCTGT/CCAAAT 1 -- us2k1 tfbs36Minor allele frequency- C:0.01NS EA NA 560
    rs114236661,2
    C--26536970(+) AAAAAA/-GACCC 1 -- us2k1 trp31Minor allele frequency- -:0.00CSA 2
    rs2016218681,2
    C--26536970(+) TTGAAA/GAAAAA 1 -- us2k10--------
    rs2012678221,2
    C--26536984(-) TGGGTC/TTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HMGN4 (26538572 - 26547165 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HMGN4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HMGN4
    DNA2.0 Custom Variant and Variant Library Synthesis for HMGN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with HMGN4           About GenesLikeMe

    Genetic Association Database (GAD): HMGN4

    Export disorders for HMGN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HMGN4 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with HMGN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PubMed id 9149941)1, 2, 3 Ruddy D.A.... Feder J.N. (Genome Res. 1997)
    2. HMGN4, a newly discovered nucleosome-binding protein encoded by an intronless gene. (PubMed id 11410162)1, 3, 9 Birger Y....Bustin M. (DNA Cell Biol. 2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    6. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    7. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10473 HGNC: 4989 AceView: HMGN4 Ensembl:ENSG00000182952 euGenes: HUgn10473
    ECgene: HMGN4 H-InvDB: HMGN4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HMGN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HMGN4 gene:
    Search GeneIP for patents involving HMGN4

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Block miRNA regulation of human, mouse, rat HMGN4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HMGN4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMGN4 Predesigned siRNA for gene silencing in human, mouse, rat HMGN4
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     Custom PCR Arrays for HMGN4 Search Chromatin IP Primers for HMGN4
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     Search Addgene for plasmids for HMGN4
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      eBioscience FlowRNA Probe Sets
           
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