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Aliases for HMGN4 Gene

Aliases for HMGN4 Gene

  • High Mobility Group Nucleosomal Binding Domain 4 2 3
  • High-Mobility Group (Nonhistone Chromosomal) Protein 17-Like 3 2 3
  • Non-Histone Chromosomal Protein HMG-17-Like 3 3 4
  • HMG17L3 3 4
  • NHC 3 4
  • High Mobility Group Nucleosome-Binding Domain-Containing Protein 4 3
  • High-Mobility Group Protein 17-Like 3 3
  • Non-Histone Chromosomal Protein 4
  • High Mobility Group Protein N4 3

External Ids for HMGN4 Gene

Previous HGNC Symbols for HMGN4 Gene

  • HMG17L3

Previous GeneCards Identifiers for HMGN4 Gene

  • GC06P026602
  • GC06P026646
  • GC06P026481

Summaries for HMGN4 Gene

Entrez Gene Summary for HMGN4 Gene

  • The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. [provided by RefSeq, Mar 2013]

GeneCards Summary for HMGN4 Gene

HMGN4 (High Mobility Group Nucleosomal Binding Domain 4) is a Protein Coding gene. GO annotations related to this gene include nucleosomal DNA binding. An important paralog of this gene is HMGN2.

Gene Wiki entry for HMGN4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGN4 Gene

Genomics for HMGN4 Gene

Regulatory Elements for HMGN4 Gene

Genomic Location for HMGN4 Gene

Start:
26,538,344 bp from pter
End:
26,546,937 bp from pter
Size:
8,594 bases
Orientation:
Plus strand

Genomic View for HMGN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMGN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGN4 Gene

Proteins for HMGN4 Gene

  • Protein details for HMGN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00479-HMGN4_HUMAN
    Recommended name:
    High mobility group nucleosome-binding domain-containing protein 4
    Protein Accession:
    O00479
    Secondary Accessions:
    • B2R4I6
    • Q53XL9

    Protein attributes for HMGN4 Gene

    Size:
    90 amino acids
    Molecular mass:
    9539 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HMGN4 Gene

Proteomics data for HMGN4 Gene at MOPED

Post-translational modifications for HMGN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMGN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HMGN4 Gene

Domains for HMGN4 Gene

Gene Families for HMGN4 Gene

HGNC:
  • HMG :High-mobility group / Canonical

Protein Domains for HMGN4 Gene

Suggested Antigen Peptide Sequences for HMGN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00479

UniProtKB/Swiss-Prot:

HMGN4_HUMAN :
  • O00479
Family:
  • Belongs to the HMGN family.
genes like me logo Genes that share domains with HMGN4: view

Function for HMGN4 Gene

Gene Ontology (GO) - Molecular Function for HMGN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031492 nucleosomal DNA binding IEA --
genes like me logo Genes that share ontologies with HMGN4: view

Phenotypes for HMGN4 Gene

genes like me logo Genes that share phenotypes with HMGN4: view

miRNA for HMGN4 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HMGN4 Gene

Localization for HMGN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGN4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMGN4 Gene COMPARTMENTS Subcellular localization image for HMGN4 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for HMGN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HMGN4: view

Pathways for HMGN4 Gene

SuperPathways for HMGN4 Gene

No Data Available

Interacting Proteins for HMGN4 Gene

Selected Interacting proteins: O00479-HMGN4_HUMAN for HMGN4 Gene via I2D

Symbol External ID(s) Details
EWSR1

Gene Ontology (GO) - Biological Process for HMGN4 Gene

None

No data available for Pathways by source for HMGN4 Gene

Transcripts for HMGN4 Gene

mRNA/cDNA for HMGN4 Gene

(359) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HMGN4 Gene

High mobility group nucleosomal binding domain 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMGN4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - - -

Relevant External Links for HMGN4 Gene

GeneLoc Exon Structure for
HMGN4
ECgene alternative splicing isoforms for
HMGN4

Expression for HMGN4 Gene

mRNA expression in normal human tissues for HMGN4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HMGN4 Gene

SOURCE GeneReport for Unigene cluster for HMGN4 Gene Hs.236774

genes like me logo Genes that share expressions with HMGN4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HMGN4 Gene

Orthologs for HMGN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMGN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMGN4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 87 (a)
OneToMany
HMGN4 35
  • 91.48 (n)
  • 91.11 (a)
HMGN4 36
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HMGN4 36
  • 87 (a)
OneToOne
LOC100856364 35
  • 88.52 (n)
  • 86.67 (a)
mouse
(Mus musculus)
Mammalia Gm10282 36
  • 86 (a)
OneToMany
Gm16494 36
  • 80 (a)
OneToMany
Hmgn2 36
  • 86 (a)
OneToMany
Hmgn2l6 16
oppossum
(Monodelphis domestica)
Mammalia HMGN4 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves HMGN2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HMGN4 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hmgn2 35
  • 71.11 (n)
  • 73.33 (a)
Species with no ortholog for HMGN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HMGN4 Gene

ENSEMBL:
Gene Tree for HMGN4 (if available)
TreeFam:
Gene Tree for HMGN4 (if available)

Paralogs for HMGN4 Gene

Paralogs for HMGN4 Gene

Selected SIMAP similar genes for HMGN4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HMGN4 Gene

genes like me logo Genes that share paralogs with HMGN4: view

Variants for HMGN4 Gene

Sequence variations from dbSNP and Humsavar for HMGN4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs4573 -- 26,546,580(-) ttgca(A/G)taatc utr-variant-3-prime
rs4871 -- 26,545,404(-) TTGTT(C/T)CCATC synonymous-codon, reference
rs15580 -- 26,545,820(+) TCTCC(C/T)CTTTC utr-variant-3-prime
rs755659 -- 26,545,105(+) GTTTA(C/T)GCTTT intron-variant
rs1321481 -- 26,537,982(+) AAAAC(A/T)CGCAC upstream-variant-2KB

Relevant External Links for HMGN4 Gene

HapMap Linkage Disequilibrium report
HMGN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HMGN4 Gene

Disorders for HMGN4 Gene

Relevant External Links for HMGN4

Genetic Association Database (GAD)
HMGN4
genes like me logo Genes that share disorders with HMGN4: view

No data available for UniProtKB/Swiss-Prot for HMGN4 Gene

Publications for HMGN4 Gene

  1. HMGN4, a newly discovered nucleosome-binding protein encoded by an intronless gene. (PMID: 11410162) Birger Y. … Bustin M. (DNA Cell Biol. 2001) 2 3 23
  2. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy D.A. … Feder J.N. (Genome Res. 1997) 2 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for HMGN4 Gene

Sources for HMGN4 Gene

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