HMGN4 Gene
protein-coding GIFtS: 49
GCID: GC06P026538
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|
high mobility group nucleosomal binding domain 4(Previous name: high-mobility group (nonhistone chromosomal) protein 17-like...)
(Previous symbol: HMG17L3)
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Aliases
for HMGN4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| High Mobility Group Nucleosomal Binding Domain 41 2 | | High Mobility Group Nucleosome-Binding Domain-Containing Protein 42 | | HMG17L31 2 3 | | High Mobility Group Protein N42 | | NHC1 2 3 | | High-Mobility Group Protein 17-Like 32 | | High-Mobility Group (Nonhistone Chromosomal) Protein 17-Like 31 2 | | Non-Histone Chromosomal Protein3 | | Non-Histone Chromosomal Protein HMG-17-Like 32 3 | | |
Export aliases for HMGN4 gene to outside databasesPrevious GC identifers: GC06P026602 GC06P026646 GC06P026481 |
Summaries
for HMGN4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HMGN4:
The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of thechromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Transcript variantsutilizing alternative polyadenylation signals exist for this gene. (provided by RefSeq, Jul 2008)
Gene Wiki entry for HMGN4
|
Genomic Views
for HMGN4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HMGN4 gene promoter:
STAT1 STAT4 STAT2 STAT3 STAT1beta STAT5A HNF-3beta STAT1alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for HMGN4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMGN4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p21.3HMGN4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P026538: view genomic region
(about GC identifiers)
Start:
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26,538,572 bp from pter |
End:
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26,547,165 bp from pter |
Size:
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8,594 bases |
Orientation:
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plus strand |
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Proteins
for HMGN4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HMGN4_HUMAN, O00479 (See
protein sequence)Recommended Name: High mobility group nucleosome-binding domain-containing protein 4 Size: 90 amino acids; 9539 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B2R4I6 Q53XL9Explore the universe of human proteins at neXtProt for HMGN4: NX_O00479
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00479
HMGN4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006344.1
ENSEMBL proteins: ENSP00000366798 ENSP00000327691
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HMGN4 for ontologies About GeneDecksing
HMGN4 Antibody Products:
Assay Products for HMGN4: |
Protein
Domains /
Families
for HMGN4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HMGN4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O00479ProtoNet protein and cluster: O00479 1 Blocks protein family: IPB000079 High mobility group protein HMG14 and HMG17
UniProtKB/Swiss-Prot: HMGN4_HUMAN, O00479Similarity: Belongs to the HMGN family |
Function
for HMGN4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMGN4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMGN4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HMGN4 (NM_006353) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMGN4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGN4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGN4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031492 | nucleosomal DNA binding |
IEA | -- |
HMGN4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HMGN4:
|
Pathways & Interactions
for HMGN4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HMGN4
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for HMGN4 (O004793 ENSP000003276914) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for HMGN4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HMGN4
Search CenterWatch for drugs/clinical trials and news about HMGN4
|
Transcripts
for HMGN4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HMGN4 gene: NM_006353.2 Unigene Cluster for HMGN4: High mobility group nucleosomal binding domain 4 Hs.236774 [show with all ESTs]Unigene Representative Sequence: NM_0063533 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377575 ENST00000477243 ENST00000328219(uc003nig.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMGN4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMGN4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HMGN4 (NM_006353) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMGN4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGN4 |
Additional cDNA sequence: AK311841.1 BC001282.1 BC035998.1 BT009824.1 7 DOTS entries: DT.75139983 DT.100823375 DT.100823379 DT.92443710 DT.95136662 DT.100823378 DT.91945958 24/359 AceView cDNA sequences (see all 359): CR601032 AI139586 AA487320 BM971905 AW470025 AI359668 N53390 N53731 BM782566 AA828479 CN480700 BM836380 AA487257 BF058150 AW239297 F30862 BM450270 AA487374 BM968231 CR625909 BM693092 BF516055 BU507201 CA405940
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for HMGN4 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|
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| SP1: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for HMGN4
|
Expression
for HMGN4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HMGN4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATATGGTAC
About this image
See HMGN4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HMGN4
SOURCE GeneReport for Unigene cluster: Hs.236774
SABiosciences Custom PCR Arrays for HMGN4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMGN4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HMGN4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMGN4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMGN4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGN4 |
Orthologs
for HMGN4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HMGN4 gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HMGN2_CHICK6 |
Non-histone chromosomal protein HMG-17 |
83(a) |
1 → many |
23(132497-135896) |
lizard
(Anolis carolinensis) |
Reptilia |
HMGN46 |
-- |
82(a) |
1 → many |
GL343480.1(638060-642770) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1584096si:dkeyp-86f7.36 |
si:dkeyp-86f7.3 |
42(a)42(a) |
many ↔ manymany ↔ many |
5(24752963-24756103) 14(9593656-9600394) |
ENSEMBL Gene Tree for HMGN4 (if available)
TreeFam Gene Tree for HMGN4 (if available) |
Paralogs
for HMGN4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HMGN4 gene
- HMGN22 HMGN12 HMGN32
1 SIMAP similar gene for HMGN4 using alignment to 1 protein entry: HMGN4_HUMAN:HMGN2
HMGN4 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for HMGN4
PGOHUM00000258931 PGOHUM00000259817
|
Genomic Variants
for HMGN4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HMGN4 (26538572 - 26547165 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HMGN4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMGN4 |
|
Disorders
/ Diseases
for HMGN4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HMGN4 for disorders About GeneDecksing
2  diseases for HMGN4: About MalaCardshypophosphatasia hemochromatosis
Export disorders for HMGN4 gene to outside databases
|
Publications
for HMGN4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HMGN4 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with HMGN4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PubMed id 9149941)1, 2, 3 Ruddy D.A.... Feder J.N. (1997)
- HMGN4, a newly discovered nucleosome-binding protein encoded by an intronless gene. (PubMed id 11410162)1, 3, 9 Birger Y....Bustin M. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for HMGN4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HMGN4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HMGN4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HMGN4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HMGN4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HMGN4 gene:
Search GeneIP for patents involving HMGN4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HMGN4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HMGN4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMGN4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMGN4 | | | OriGene Protein Over-expression Lysate for HMGN4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HMGN4 | | OriGene 3'-UTR Clone for HMGN4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMGN4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMGN4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HMGN4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HMGN4 | | OriGene Custom Protein Services for HMGN4 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HMGN4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMGN4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMGN4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMGN4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMGN4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMGN4 |
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| |  |  |  |  | | | | |
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 | | | HMGN4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGN4 |
|  |  |  | | | | ThermoFisher Antibodies for HMGN4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGN4 |
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