Aliases for HMGN4 Gene
Aliases for HMGN4 Gene
- High Mobility Group Nucleosomal Binding Domain 4 2 3 5
- High-Mobility Group (Nonhistone Chromosomal) Protein 17-Like 3 2 3
- Non-Histone Chromosomal Protein HMG-17-Like 3 3 4
- HMG17L3 3 4
- NHC 3 4
- High Mobility Group Nucleosome-Binding Domain-Containing Protein 4 3
- High-Mobility Group Protein 17-Like 3 3
- Non-Histone Chromosomal Protein 4
- High Mobility Group Protein N4 3
External Ids for HMGN4 Gene
- HGNC: 4989
- Entrez Gene: 10473
- Ensembl: ENSG00000182952
- UniProtKB: O00479
Previous HGNC Symbols for HMGN4 Gene
- HMG17L3
Previous GeneCards Identifiers for HMGN4 Gene
- GC06P026602
- GC06P026646
- GC06P026481
Summaries for HMGN4 Gene
-
The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. [provided by RefSeq, Mar 2013]
GeneCards Summary for HMGN4 Gene
HMGN4 (High Mobility Group Nucleosomal Binding Domain 4) is a Protein Coding gene. GO annotations related to this gene include nucleosomal DNA binding. An important paralog of this gene is HMGN2.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGN4 Gene
Genomics for HMGN4 Gene
Regulatory Elements for HMGN4 Gene
Enhancers for HMGN4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HMGN4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HMGN4 gene promoter:
Regulatory Element Products
Genomic Location for HMGN4 Gene
- Chromosome:
- 6
- Start:
- 26,538,344 bp from pter
- End:
- 26,546,937 bp from pter
- Size:
- 8,594 bases
- Orientation:
- Plus strand
Genomic View for HMGN4 Gene
Genes around HMGN4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
HMGN4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMGN4 Gene
Proteins for HMGN4 Gene
-
Protein details for HMGN4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00479-HMGN4_HUMAN
- Recommended name:
- High mobility group nucleosome-binding domain-containing protein 4
- Protein Accession:
- O00479
- B2R4I6
- Q53XL9
Protein attributes for HMGN4 Gene
- Size:
- 90 amino acids
- Molecular mass:
- 9539 Da
- Quaternary structure:
- No Data Available
Protein Expression for HMGN4 Gene
Post-translational modifications for HMGN4 Gene
Other Protein References for HMGN4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- antibodies-online Antibodies for HMGN4: See all 11
- Search GeneTex for Antibodies for HMGN4
Protein Products
-
OriGene Purified Proteins for HMGN4
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGN4
- Origene Custom Protein Services for HMGN4
- antibodies-online Proteins for HMGN4: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HMGN4
Assay Products
No data available for DME Specific Peptides for HMGN4 Gene
Domains & Families for HMGN4 Gene
Gene Families for HMGN4 Gene
Protein Domains for HMGN4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMGN4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00479- Family:
-
- Belongs to the HMGN family.
Function for HMGN4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 21044950 |
| GO:0031492 | nucleosomal DNA binding | IEA | -- |
Phenotypes for HMGN4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGN4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGN4 gene
- Search ViGene Biosciences for HMGN4
CRISPR Products
-
OriGene CRISPR knockouts for HMGN4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGN4
- GenScript: Design CRISPR guide RNA sequences for HMGN4
miRNA for HMGN4 Gene
- miRTarBase miRNAs that target HMGN4
-
- hsa-mir-124-3p (MIRT022292)
- hsa-mir-7-5p (MIRT025702)
- hsa-mir-615-3p (MIRT039769)
- hsa-mir-505-3p (MIRT041040)
- hsa-mir-6830-5p (MIRT409794)
- hsa-mir-340-5p (MIRT445490)
- hsa-mir-3163 (MIRT445491)
- hsa-mir-5582-3p (MIRT445492)
- hsa-mir-548f-3p (MIRT445493)
- hsa-mir-548e-3p (MIRT445494)
- hsa-mir-548az-3p (MIRT445495)
- hsa-mir-548ar-3p (MIRT445496)
- hsa-mir-548a-3p (MIRT445497)
- hsa-mir-2113 (MIRT560248)
- hsa-mir-5010-3p (MIRT560249)
- hsa-mir-5695 (MIRT560250)
- hsa-mir-3654 (MIRT560251)
- hsa-mir-1243 (MIRT560252)
- hsa-mir-3145-5p (MIRT560253)
miRNA Products
- Search ViGene Biosciences for HMGN4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMGN4
- Browse OriGene Inhibitory RNA Products For HMGN4
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGN4 gene
Clone Products
-
OriGene ORF clones in human for HMGN4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HMGN4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HMGN4
-
ViGene Biosciences adenoviral particle packaged cDNA for HMGN4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGN4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGN4 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMGN4 Gene
Localization for HMGN4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMGN4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
Transcripts for HMGN4 Gene
mRNA/cDNA for HMGN4 Gene
- (4) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (359) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HMGN4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HMGN4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGN4
- GenScript: Design CRISPR guide RNA sequences for HMGN4
miRNA Products
- Search ViGene Biosciences for HMGN4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMGN4
- Browse OriGene Inhibitory RNA Products For HMGN4
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGN4 gene
Clone Products
-
OriGene ORF clones in human for HMGN4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HMGN4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||
| SP5: | - | - | - | - |
Expression for HMGN4 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (46.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HMGN4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HMGN4 Gene:
HMGN4SOURCE GeneReport for Unigene cluster for HMGN4 Gene:
Hs.236774Evidence on tissue expression from TISSUES for HMGN4 Gene
- Nervous system(4.8)
Primer Products
-
OriGene qPCR primer pairs and template standards for HMGN4
-
OriGene qPCR primer pairs for HMGN4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGN4 Gene
Orthologs for HMGN4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMGN4 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HMGN4 34 35 |
|
||
| -- 35 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | LOC100856364 34 |
|
||
| HMGN4 35 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Gm10282 35 |
|
OneToMany | |
| Hmgn2 35 |
|
OneToMany | |||
| Gm16494 35 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | HMGN4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | HMGN2 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HMGN4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hmgn2 34 |
|
- Species where no ortholog for HMGN4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HMGN4 Gene
(1) SIMAP similar genes for HMGN4 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for HMGN4 Gene
Variants for HMGN4 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000055525 | -- | 26,538,047(+) | AGCCC(C/T)TAGTG | upstream-variant-2KB | |
| rs1000385579 | -- | 26,539,338(+) | GGTGC(A/G)ATGGT | intron-variant | |
| rs1000728839 | -- | 26,540,179(+) | CTACC(C/G)CTGCA | intron-variant | |
| rs1000756525 | -- | 26,538,772(+) | CTAAT(A/C)GGCGT | intron-variant | |
| rs1001050671 | -- | 26,546,524(+) | TTTCT(A/T)TTCTG | utr-variant-3-prime |
Residual Variation Intolerance Score:
71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.41;
42.59% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HMGN4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HMGN4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HMGN4 Gene
Disorders for HMGN4 Gene
Relevant External Links for HMGN4
No disorders were found for HMGN4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMGN4 Gene
Publications for HMGN4 Gene
- HMGN4, a newly discovered nucleosome-binding protein encoded by an intronless gene. (PMID: 11410162) Birger Y. … Bustin M. (DNA Cell Biol. 2001) 2 3 22 64
- A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy D.A. … Feder J.N. (Genome Res. 1997) 2 3 4 64
- Serine ADP-ribosylation depends on HPF1. (PMID: 28190768) Bonfiglio J.J. … Matic I. (Mol. Cell 2017) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
Products for HMGN4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HMGN4
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGN4
- Origene Custom Protein Services for HMGN4
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMGN4
- Browse OriGene Inhibitory RNA Products For HMGN4
- OriGene qPCR primer pairs and template standards for HMGN4
- OriGene qPCR primer pairs for HMGN4
- OriGene CRISPR knockouts for HMGN4
- OriGene ORF clones in human for HMGN4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HMGN4
- GenScript: Next-day shipping cDNA ORF clone for HMGN4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HMGN4
- GenScript Custom Assay Services for HMGN4
- GenScript Custom overexpressing Cell Line Services for HMGN4
- GenScript: Design CRISPR guide RNA sequences for HMGN4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HMGN4
- Sino Biological Human cDNA Clone for HMGN4
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals proteins and lysates for HMGN4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for HMGN4: See all 11
- Search antibodies-online for kits
- antibodies-online Proteins for HMGN4: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for HMGN4
- Search GeneTex for Proteins for HMGN4
- ViGene Biosciences adenoviral particle packaged cDNA for HMGN4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HMGN4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HMGN4 gene
- Search ViGene Biosciences for HMGN4
- Horizon Cell Lines for HMGN4
- Cyagen custom Knockout/knockin (KOKI) mouse models for HMGN4
- VectorBuilder custom plasmid, inducible vectors for HMGN4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMGN4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HMGN4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer