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HMGN3 Gene

protein-coding   GIFtS: 50
GCID: GC06M079967

High Mobility Group Nucleosomal Binding Domain 3

(Previous name: thyroid hormone receptor interactor 7)
(Previous symbol: TRIP7)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
High Mobility Group Nucleosomal Binding Domain 31 2     High Mobility Group Nucleosome-Binding Domain-Containing Protein 32
TRIP71 2 3 5     Thyroid Hormone Receptor Interacting Protein 72
TR-Interacting Protein 72 3     TRIP-73
Thyroid Hormone Receptor Interactor 71     Thyroid Receptor-Interacting Protein 73
PNAS-252     

External Ids:    HGNC: 123121   Entrez Gene: 93242   Ensembl: ENSG000001184187   OMIM: 6045025   UniProtKB: Q156513   

Export aliases for HMGN3 gene to outside databases

Previous GC identifers: GC06M079853 GC06M079906 GC06M077104


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HMGN3 Gene:
Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of
specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the
presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the
compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2011)

GeneCards Summary for HMGN3 Gene:
HMGN3 (high mobility group nucleosomal binding domain 3) is a protein-coding gene. GO annotations related to this gene include thyroid hormone receptor binding and nucleosomal DNA binding.

UniProtKB/Swiss-Prot: HMGN3_HUMAN, Q15651
Function: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes
such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the
expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter
SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors.
Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic
junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular
development and astrocyte function (By similarity)

Gene Wiki entry for HMGN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HMGN3 gene promoter:
         FOXD1   HNF-3beta   NF-AT   C/EBPalpha   Evi-1   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHMGN3 promoter sequence
   Search Chromatin IP Primers for HMGN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMGN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.1   Ensembl cytogenetic band:  6q14.1   HGNC cytogenetic band: 6q14.3

HMGN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMGN3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M079967:  view genomic region     (about GC identifiers)

Start:
79,910,962 bp from pter      End:
79,944,455 bp from pter
Size:
33,494 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HMGN3_HUMAN, Q15651 (See protein sequence)
Recommended Name: High mobility group nucleosome-binding domain-containing protein 3  
Size: 99 amino acids; 10666 Da
Subunit: Interacts with the ligand binding domain of the thyroid receptor (TR) (in vitro). Requires the presence
of thyroid hormone for its interaction. Interacts with nucleosomes
Sequence caution: Sequence=AAA73877.1; Type=Erroneous initiation;
Secondary accessions: B2RD37 Q5HYD3 Q7RTT0 Q969M5 Q9BZT7
Alternative splicing: 2 isoforms:  Q15651-1   Q15651-2   

Explore the universe of human proteins at neXtProt for HMGN3: NX_Q15651

Explore proteomics data for HMGN3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HMGN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001188291.1  NP_001188292.1  NP_004233.1  NP_620058.1  

    ENSEMBL proteins: 
     ENSP00000341267   ENSP00000275036  

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    antibodies-online proteins for HMGN3 (5 products) 

     
    antibodies-online peptides for HMGN3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HMG: High-mobility group / Canonical

    1 InterPro protein domain:
     IPR000079 HMGN_fam

    Graphical View of Domain Structure for InterPro Entry Q15651

    ProtoNet protein and cluster: Q15651

    1 Blocks protein domain: IPB000079 High mobility group protein HMG14 and HMG17

    UniProtKB/Swiss-Prot: HMGN3_HUMAN, Q15651
    Similarity: Belongs to the HMGN family


    Find genes that share domains with HMGN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMGN3_HUMAN, Q15651
    Function: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes
    such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the
    expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter
    SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors.
    Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic
    junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular
    development and astrocyte function (By similarity)
    Induction: By estrogen

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding ----
    GO:0031492nucleosomal DNA binding IEA--
    GO:0046966thyroid hormone receptor binding NAS7776974
         
    Find genes that share ontologies with HMGN3           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hmgn3):
     homeostasis/metabolism  no phenotypic analysis 

    Find genes that share phenotypes with HMGN3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hmgn3tm1.2Mbus for HMGN3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HMGN3
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    hsa-miR-4291 hsa-miR-137 hsa-miR-520d-5p hsa-miR-29c hsa-miR-29a hsa-miR-548x hsa-miR-3143 hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidHMGN3 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HMGN3_HUMAN, Q15651: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with HMGN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HMGN3
    Interactions:

        Search GeneGlobe Interaction Network for HMGN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for HMGN3 (Q156511, 3 ENSP000003412674) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 3, ENSP000003390074EBI-1758705,EBI-401755 I2D: score=2 STRING: ENSP00000339007
    THRBP108283I2D: score=3 
    VDRP114733I2D: score=3 
    SMAD2Q157963I2D: score=1 
    TERF1ENSP000002766034STRING: ENSP00000276603
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0008150biological_process ND--
    GO:0016568chromatin modification IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--
    GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity IEA--

    Find genes that share ontologies with HMGN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HMGN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HMGN3 gene (4 alternative transcripts): 
    NM_001201362.1  NM_001201363.1  NM_004242.3  NM_138730.2  

    Unigene Cluster for HMGN3:

    High mobility group nucleosomal binding domain 3
    Hs.77558  [show with all ESTs]
    Unigene Representative Sequence: BX648085
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344726(uc021zbz.1 uc003pit.3 uc003piu.2) ENST00000275036(uc003pis.3)

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    Selected qRT-PCR Assays for microRNAs that regulate HMGN3 (see all 16):
    hsa-miR-4291 hsa-miR-137 hsa-miR-520d-5p hsa-miR-29c hsa-miR-29a hsa-miR-548x hsa-miR-3143 hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidHMGN3 3' UTR sequence
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    Additional mRNA sequence: 

    AF274949.1 AF401520.1 AK315391.1 AY043282.1 BC009529.2 BX648085.1 L40357.1 

    15 DOTS entries:

    DT.75146608  DT.95102491  DT.95326107  DT.100789896  DT.100744948  DT.95302036  DT.91646468  DT.95302033 
    DT.95087498  DT.97775329  DT.121305477  DT.448792  DT.92445913  DT.100789892  DT.40201792 

    Selected AceView cDNA sequences (see all 381):

    BM352763 AI672466 BF939506 BM739279 AI348654 CR599808 AA747121 CA306359 
    CB069941 BF933178 AA244274 BM927225 BF934471 AW026647 AF401520 AI362567 
    AI358625 AI028183 BM311831 BF933194 AI350223 BU619570 CK822321 CF528375 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HMGN3 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d
    SP1:                                            -           -                             -     -     -     -                           
    SP2:                                            -           -                             -     -     -     -                           
    SP3:                                            -           -                                   -     -     -                           
    SP4:                                            -           -                       -     -     -     -     -                           
    SP5:                                            -           -                 -     -     -     -     -     -                           


    ECgene alternative splicing isoforms for HMGN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HMGN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATAGTTGTG
    HMGN3 Expression
    About this image


    HMGN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Somatic Cells Ovigerous Cord
             Oviduct
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Liver Bud
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
    HMGN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMGN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77558

    UniProtKB/Swiss-Prot: HMGN3_HUMAN, Q15651
    Tissue specificity: Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary
    gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HMGN3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmgn35 high mobility group nucleosomal binding domain 3   --   9 (45.29 cM) 83109948 
    chicken
    (Gallus gallus)
    Aves HMGN31 high mobility group nucleosomal binding domain 3 84.78(n)
    80.43(a)
      421853  NM_001006412.1  NP_001006412.1 
    lizard
    (Anolis carolinensis)
    Reptilia HMGN36
    high mobility group nucleosomal binding domain 3
    74(a)
    1 ↔ 1
    1(199635813-199649360)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC642522 hypothetical protein MGC64252 87.3(n)    BC041718.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570367902   -- 80.18(n)   334804  57036790 


    ENSEMBL Gene Tree for HMGN3 (if available)
    TreeFam Gene Tree for HMGN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HMGN3 gene
    2 SIMAP similar genes for HMGN3 using alignment to 1 protein entry:     HMGN3_HUMAN:
    HMGN1    HMGN5

    Find genes that share paralogs with HMGN3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HMGN3
    PGOHUM00000245004


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HMGN3 (see all 671)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006750701,2
    C--79854153(+) TTATG-/TTTTTTT
    TTTTTTTTTT
    TTTTT
    4 -- ds50010--------
    rs570572781,2
    C--79854186(+) TTTTT-/TTTTTTT/TTT
    TTTTTTTTTTTTTT
    ACTAG
    4 -- ds50011NA 2
    rs1872373821,2
    --79854409(+) AGATAC/TCGCTA 4 -- ds50010--------
    rs1511428681,2
    C--79854443(+) TATATC/TTTCTG 4 -- ds50010--------
    rs1921686351,2
    --79854508(+) TTCTGC/TAGACA 4 -- ut310--------
    rs1451156671,2
    C--79854684(+) AGGACC/TAAATT 4 -- ut310--------
    rs340437891,2
    C,F--79854731(+) ACACAG/ACTTCC 4 -- ut316Minor allele frequency- A:0.14NA CSA WA 248
    rs1475963211,2
    C--79854818(+) CCATCC/TTTATA 4 -- ut310--------
    rs94486571,2
    C,F,H--79854831(+) TTTTCG/ATATGC 4 -- ut31 ese319Minor allele frequency- A:0.13NA NS EA CSA WA 2032
    rs1826810161,2
    C--79854955(+) TCTCCC/TTCGTT 6 E syn1 ut310--------

    HapMap Linkage Disequilibrium report for HMGN3 (79910962 - 79944455 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HMGN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830706CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HMGN3
    DNA2.0 Custom Variant and Variant Library Synthesis for HMGN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604502    OMIM disorders: --


    Find genes that share disorders with HMGN3           About GenesLikeMe


    Export disorders for HMGN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HMGN3 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with HMGN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome- binding proteins. (PubMed id 11356838)1, 2, 3, 9 West K.L.... Bustin M. (J. Biol. Chem. 2001)
    2. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W.... Moore D.D. (Mol. Endocrinol. 1995)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Differential display RT-PCR analysis of enterovirus-71-infected rhabdomyosarcoma cells reveals mRNA expression responses of multiple human genes with known and novel functions. (PubMed id 12033773)1, 2 Leong P.W.... Chow V.T.K. (Virology 2002)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Genome-wide association study identifies HMGN3 locus for spine bone size variation in Chinese. (PubMed id 21947420)1 Lei S.F....Deng H.W. (Hum. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9324 HGNC: 12312 AceView: HMGN3 Ensembl:ENSG00000118418 euGenes: HUgn9324
    ECgene: HMGN3 H-InvDB: HMGN3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HMGN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HMGN3 gene:
    Search GeneIP for patents involving HMGN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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