Aliases for HMGN3 Gene
Aliases for HMGN3 Gene
External Ids for HMGN3 Gene
- HGNC: 12312
- Entrez Gene: 9324
- Ensembl: ENSG00000118418
- OMIM: 604502
- UniProtKB: Q15651
Previous HGNC Symbols for HMGN3 Gene
- TRIP7
Previous GeneCards Identifiers for HMGN3 Gene
- GC06M079853
- GC06M079906
- GC06M079967
- GC06M077104
Summaries for HMGN3 Gene
-
The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016]
GeneCards Summary for HMGN3 Gene
HMGN3 (High Mobility Group Nucleosomal Binding Domain 3) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and thyroid hormone receptor binding.
UniProtKB/Swiss-Prot for HMGN3 Gene
-
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGN3 Gene
Genomics for HMGN3 Gene
Regulatory Elements for HMGN3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G079269 | 1 | Ensembl ENCODE | 10.6 | -35.5 | -35494 | 0.8 | ATF1 TAL1 ZKSCAN1 TCF12 ZNF766 GATA2 ELK1 NCOR1 FOXK2 SMARCE1 | HMGN3 ENSG00000220154 |
| GH06G079256 | 0.8 | ENCODE | 11.4 | -22.9 | -22905 | 1.4 | ESRRA FOXA2 JUN BACH1 ZNF175 PYGO2 ZNF644 FOSL1 IRF9 DIDO1 | HMGN3 HMGN3-AS1 ENSG00000220154 |
| GH06G079372 | 0.5 | ENCODE | 9.7 | -138.6 | -138625 | 0.9 | GATA3 RFX1 GATA2 EBF1 TRIM28 | HMGN3 ENSG00000218029 ENSG00000262048 |
| GH06G079300 | 0.4 | ENCODE | 10.6 | -66.7 | -66743 | 1.8 | CTCF RAD21 | HMGN3 ENSG00000201464 GC06M079302 ENSG00000220154 |
| GH06G079376 | 0.7 | ENCODE | 4.6 | -142.8 | -142763 | 2.4 | PKNOX1 HLF FEZF1 NR2F2 PRDM6 GATA3 GATA2 ZSCAN5C FOS WT1 | HMGN3 ENSG00000218029 ENSG00000262048 |
- Transcription factor binding sites by QIAGEN in the HMGN3 gene promoter:
Regulatory Element Products
Genomic Location for HMGN3 Gene
- Chromosome:
- 6
- Start:
- 79,201,245 bp from pter
- End:
- 79,234,738 bp from pter
- Size:
- 33,494 bases
- Orientation:
- Minus strand
Genomic View for HMGN3 Gene
- Cytogenetic band:
-
- 6q14.1 by Ensembl
- 6q14.1 by Entrez Gene
- 6q14.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMGN3 Gene
Proteins for HMGN3 Gene
-
Protein details for HMGN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15651-HMGN3_HUMAN
- Recommended name:
- High mobility group nucleosome-binding domain-containing protein 3
- Protein Accession:
- Q15651
- B2RD37
- Q5HYD3
- Q7RTT0
- Q969M5
- Q9BZT7
Protein attributes for HMGN3 Gene
- Size:
- 99 amino acids
- Molecular mass:
- 10666 Da
- Quaternary structure:
-
- Interacts with the ligand binding domain of the thyroid receptor (TR) (in vitro). Requires the presence of thyroid hormone for its interaction. Interacts with nucleosomes.
- SequenceCaution:
-
- Sequence=AAA73877.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for HMGN3 Gene
Post-translational modifications for HMGN3 Gene
Other Protein References for HMGN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HMGN3
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- Invitrogen Antibodies for HMGN3
- antibodies-online Antibodies for HMGN3: See all 36
- GeneTex HMGN3 antibody for HMGN3
-
Santa Cruz Biotechnology (SCBT) Antibodies for HMGN3
Protein Products
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- Sino Biological Recombinant Proteins for HMGN3
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- ProSpec Recombinant Proteins for HMGN3
- antibodies-online Proteins for HMGN3: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HMGN3
Assay Products
No data available for DME Specific Peptides for HMGN3 Gene
Domains & Families for HMGN3 Gene
Gene Families for HMGN3 Gene
Protein Domains for HMGN3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMGN3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15651- Family:
-
- Belongs to the HMGN family.
Function for HMGN3 Gene
Molecular function for HMGN3 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By estrogen.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0031492 | nucleosomal DNA binding | IEA | -- |
| GO:0046966 | thyroid hormone receptor binding | NAS | 7776974 |
Phenotypes for HMGN3 Gene
- GenomeRNAi human phenotypes for HMGN3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGN3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGN3 gene
- Search ViGene Biosciences for HMGN3
CRISPR Products
-
OriGene CRISPR knockouts for HMGN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGN3
- GenScript: Design CRISPR guide RNA sequences for HMGN3
miRNA for HMGN3 Gene
- miRTarBase miRNAs that target HMGN3
miRNA Products
- Search ViGene Biosciences for HMGN3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HMGN3
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-
ViGene Biosciences ready-to-package AAV shRNAs for HMGN3 gene
Clone Products
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Cell Line Products
-
Horizon Cell Lines for HMGN3
-
ViGene Biosciences adenoviral particle packaged cDNA for HMGN3 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMGN3 Gene
Localization for HMGN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMGN3 Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for HMGN3 Gene
Interacting Proteins for HMGN3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:0016569 | covalent chromatin modification | IEA | -- |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0051091 | positive regulation of sequence-specific DNA binding transcription factor activity | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HMGN3 Gene
Transcripts for HMGN3 Gene
mRNA/cDNA for HMGN3 Gene
- (9) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (381) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HMGN3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HMGN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGN3
- GenScript: Design CRISPR guide RNA sequences for HMGN3
miRNA Products
- Search ViGene Biosciences for HMGN3
Inhibitory RNA Products
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-
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Clone Products
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | · | 8c | · | 8d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for HMGN3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HMGN3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HMGN3 Gene:
HMGN3SOURCE GeneReport for Unigene cluster for HMGN3 Gene:
Hs.77558mRNA Expression by UniProt/SwissProt for HMGN3 Gene:
Q15651-HMGN3_HUMANEvidence on tissue expression from TISSUES for HMGN3 Gene
- Nervous system(4.9)
- Lung(4.6)
- Intestine(4.3)
Primer Products
-
OriGene qPCR primer pairs for HMGN3
-
OriGene qPCR primer pairs and template standards for HMGN3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGN3 Gene
Orthologs for HMGN3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMGN3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC611307 34 |
|
||
| HMGN3 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | HMGN3 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hmgn3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hmgn3 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HMGN3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HMGN3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HMGN3 35 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | MGC64252 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hmgn3 34 35 |
|
||
| -- 34 |
|
- Species where no ortholog for HMGN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HMGN3 Gene
(2) SIMAP similar genes for HMGN3 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for HMGN3 Gene
No data available for Paralogs for HMGN3 Gene
Variants for HMGN3 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000067376 | -- | 79,211,033(+) | AAAAA(A/T)TGCCT | intron-variant | |
| rs1000081822 | -- | 79,217,807(+) | AGGGA(G/T)TGCGA | intron-variant | |
| rs1000138877 | -- | 79,212,378(+) | TCCTT(A/T)CTTTG | intron-variant | |
| rs1000175606 | -- | 79,218,000(+) | CCAGT(C/T)TGAAC | intron-variant | |
| rs1000295568 | -- | 79,224,046(+) | AATTA(C/T)GTGCA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3609679 | CNV | loss | 21293372 |
| esv3609684 | CNV | loss | 21293372 |
| nsv830706 | CNV | gain | 17160897 |
Relevant External Links for HMGN3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HMGN3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGN3 Gene
Disorders for HMGN3 Gene
Relevant External Links for HMGN3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HMGN3
No disorders were found for HMGN3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMGN3 Gene
Publications for HMGN3 Gene
- HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome- binding proteins. (PMID: 11356838) West K.L. … Bustin M. (J. Biol. Chem. 2001) 2 3 4 22 64
- Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 3 4 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Chromosomal proteins HMGN3a and HMGN3b regulate the expression of glycine transporter 1. (PMID: 15082770) West K.L. … Bustin M. (Mol. Cell. Biol. 2004) 3 22 64
Products for HMGN3 Gene
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- Custom Antibody ServicesOriGene Antibodies for HMGN3
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- Novus Biologicals Antibodies for HMGN3
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- Novus Biologicals
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- ProSpec Recombinant Proteins for HMGN3
- antibodies-online Antibodies for HMGN3: See all 36
- Search antibodies-online for kits
- antibodies-online Proteins for HMGN3: See all 9
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- GeneTex HMGN3 antibody for HMGN3
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- ViGene Biosciences adenoviral particle packaged cDNA for HMGN3 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for HMGN3
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- VectorBuilder custom plasmid, inducible vectors for HMGN3
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HMGN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




