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Aliases for HMGN2 Gene

Aliases for HMGN2 Gene

  • High Mobility Group Nucleosomal Binding Domain 2 2 3 5
  • High Mobility Group Nucleosome-Binding Domain-Containing Protein 2 3 4
  • High-Mobility Group (Nonhistone Chromosomal) Protein 17 2 3
  • High-Mobility Group Nucleosomal Binding Domain 2 2 3
  • HMG17 3 4
  • Nonhistone Chromosomal Protein HMG-17 3
  • High Mobility Group Protein N2 3

External Ids for HMGN2 Gene

Previous HGNC Symbols for HMGN2 Gene

  • HMG17

Previous GeneCards Identifiers for HMGN2 Gene

  • GC01M028726
  • GC01P025819
  • GC01P026031
  • GC01P026404
  • GC01P026406
  • GC01P026671
  • GC01P026800
  • GC01P025053

Summaries for HMGN2 Gene

Entrez Gene Summary for HMGN2 Gene

  • The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]

GeneCards Summary for HMGN2 Gene

HMGN2 (High Mobility Group Nucleosomal Binding Domain 2) is a Protein Coding gene. Diseases associated with HMGN2 include Limited Scleroderma. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include poly(A) RNA binding and nucleosomal DNA binding. An important paralog of this gene is HMGN4.

UniProtKB/Swiss-Prot for HMGN2 Gene

  • Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).

Gene Wiki entry for HMGN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGN2 Gene

Genomics for HMGN2 Gene

Regulatory Elements for HMGN2 Gene

Enhancers for HMGN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HMGN2 on UCSC Golden Path with GeneCards custom track

Promoters for HMGN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HMGN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HMGN2 Gene

26,472,411 bp from pter
26,476,642 bp from pter
4,232 bases
Plus strand

Genomic View for HMGN2 Gene

Genes around HMGN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMGN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMGN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGN2 Gene

Proteins for HMGN2 Gene

  • Protein details for HMGN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Non-histone chromosomal protein HMG-17
    Protein Accession:
    Secondary Accessions:
    • Q0VGD5
    • Q6FGI5
    • Q96C64

    Protein attributes for HMGN2 Gene

    90 amino acids
    Molecular mass:
    9393 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HMGN2 Gene

Proteomics data for HMGN2 Gene at MOPED

Post-translational modifications for HMGN2 Gene

  • Phosphorylation favors cytoplasmic localization.
  • Ubiquitination at Lys 59, Lys 64, and Lys 82
  • Modification sites at PhosphoSitePlus

Other Protein References for HMGN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HMGN2 (HMGN2)
  • Cloud-Clone Corp. Antibodies for HMGN2

No data available for DME Specific Peptides for HMGN2 Gene

Domains & Families for HMGN2 Gene

Gene Families for HMGN2 Gene

Protein Domains for HMGN2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HMGN family.
  • Belongs to the HMGN family.
genes like me logo Genes that share domains with HMGN2: view

Function for HMGN2 Gene

Molecular function for HMGN2 Gene

UniProtKB/Swiss-Prot Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).

Gene Ontology (GO) - Molecular Function for HMGN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031492 nucleosomal DNA binding IEA --
genes like me logo Genes that share ontologies with HMGN2: view
genes like me logo Genes that share phenotypes with HMGN2: view

Animal Model Products

miRNA for HMGN2 Gene

miRTarBase miRNAs that target HMGN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMGN2 Gene

Localization for HMGN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGN2 Gene

Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation.

Subcellular locations from

Jensen Localization Image for HMGN2 Gene COMPARTMENTS Subcellular localization image for HMGN2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HMGN2 Gene

Pathways & Interactions for HMGN2 Gene

genes like me logo Genes that share pathways with HMGN2: view

Pathways by source for HMGN2 Gene

1 Cell Signaling Technology pathway for HMGN2 Gene

SIGNOR curated interactions for HMGN2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HMGN2 Gene


Drugs & Compounds for HMGN2 Gene

(1) Drugs for HMGN2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HMGN2: view

Transcripts for HMGN2 Gene

Unigene Clusters for HMGN2 Gene

High mobility group nucleosomal binding domain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMGN2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5
SP1: - -
SP2: -
SP3: -

Relevant External Links for HMGN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HMGN2 Gene

mRNA expression in normal human tissues for HMGN2 Gene

Protein differential expression in normal tissues from HIPED for HMGN2 Gene

This gene is overexpressed in Stomach (23.0), Peripheral blood mononuclear cells (18.4), and Urine (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMGN2 Gene

SOURCE GeneReport for Unigene cluster for HMGN2 Gene Hs.181163

genes like me logo Genes that share expression patterns with HMGN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HMGN2 Gene

Orthologs for HMGN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMGN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HMGN2 35
  • 100 (n)
  • 100 (a)
HMGN2 36
  • 100 (a)
(Bos Taurus)
Mammalia -- 36
  • 99 (a)
(Canis familiaris)
Mammalia -- 36
  • 72 (a)
(Mus musculus)
Mammalia Gm6594 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6669 35
Species with no ortholog for HMGN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HMGN2 Gene

Gene Tree for HMGN2 (if available)
Gene Tree for HMGN2 (if available)

Paralogs for HMGN2 Gene

Paralogs for HMGN2 Gene

(1) SIMAP similar genes for HMGN2 Gene using alignment to 2 proteins: Pseudogenes for HMGN2 Gene

genes like me logo Genes that share paralogs with HMGN2: view

Variants for HMGN2 Gene

Sequence variations from dbSNP and Humsavar for HMGN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_003716 -
rs1141781 -- 26,472,575(+) CCGCG(A/C/T)CCAGC utr-variant-5-prime
rs1141782 -- 26,472,580(+) TCCAG(C/T)ACCTA utr-variant-5-prime
rs1058934 -- 26,473,119(-) GAACT(A/C)GTGGG intron-variant
rs1064616 -- 26,472,561(+) CGCGC(C/T)GCTGC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HMGN2 Gene

Variant ID Type Subtype PubMed ID
dgv202n71 CNV Loss 21882294

Variation tolerance for HMGN2 Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HMGN2 Gene

Disorders for HMGN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HMGN2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
limited scleroderma
  • crest syndrome
- elite association - COSMIC cancer census association via MalaCards
Search HMGN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HMGN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HMGN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HMGN2 Gene

Publications for HMGN2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility. (PMID: 19524541) Rattner B.P. … Kadonaga J.T. (Mol. Cell 2009) 3 23
  3. Regional fine mapping of HMG17 to chromosomal band 1p35. (PMID: 10640150) Kazmierczak B. … Bullerdiek J. (Cancer Genet. Cytogenet. 2000) 3 23
  4. Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes. (PMID: 10207070) Herrera J.E. … Bustin M. (Mol. Cell. Biol. 1999) 3 23
  5. Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport. (PMID: 9852141) Hock R. … Bustin M. (J. Cell Biol. 1998) 3 23

Products for HMGN2 Gene

Sources for HMGN2 Gene