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HMGN2 Gene

protein-coding   GIFtS: 54
GCID: GC01P026800

High Mobility Group Nucleosomal Binding Domain 2

(Previous names: high-mobility group (nonhistone chromosomal) protein 17,...)
(Previous symbol: HMG17)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
High Mobility Group Nucleosomal Binding Domain 21 2     High Mobility Group Nucleosome-Binding Domain-Containing Protein 22 3
HMG171 2 3 5     High Mobility Group Protein N22
High-Mobility Group (Nonhistone Chromosomal) Protein 171 2     Non-Histone Chromosomal Protein HMG-172
High-Mobility Group Nucleosomal Binding Domain 21 2     Nonhistone Chromosomal Protein HMG-172

External Ids:    HGNC: 49861   Entrez Gene: 31512   Ensembl: ENSG000001988307   OMIM: 1639105   UniProtKB: P052043   

Export aliases for HMGN2 gene to outside databases

Previous GC identifers: GC01M028726 GC01P025819 GC01P026031 GC01P026404 GC01P026406 GC01P026483 GC01P026671 GC01P025053


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HMGN2 Gene:
HMGN2 (high mobility group nucleosomal binding domain 2) is a protein-coding gene. Diseases associated with HMGN2 include glucagonoma, and primary pulmonary hypertension. GO annotations related to this gene include nucleosomal DNA binding. An important paralog of this gene is HMGN4.

UniProtKB/Swiss-Prot: HMGN2_HUMAN, P05204
Function: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the
histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin
conformation (By similarity)

Gene Wiki entry for HMGN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the HMGN2 gene promoter:
         TBP   NF-AT4   Sp1   TFIID   NRSF form 1   NRSF form 2   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHMGN2 promoter sequence
   Search Chromatin IP Primers for HMGN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMGN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.1

HMGN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMGN2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P026800:  view genomic region     (about GC identifiers)

Start:
26,798,902 bp from pter      End:
26,803,133 bp from pter
Size:
4,232 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HMGN2_HUMAN, P05204 (See protein sequence)
Recommended Name: Non-histone chromosomal protein HMG-17  
Size: 90 amino acids; 9393 Da
Mass spectrometry: Mass=9261.5; Method=Electrospray; Range=2-90; Source=PubMed:10739259;
Mass spectrometry: Mass=9341.3; Mass_error=1.9; Method=Electrospray; Range=2-90; Source=PubMed:10739259;
Mass spectrometry: Mass=9421.5; Method=Electrospray; Range=2-90; Source=PubMed:10739259;
Secondary accessions: Q0VGD5 Q6FGI5 Q96C64

Explore the universe of human proteins at neXtProt for HMGN2: NX_P05204

Explore proteomics data for HMGN2 at MOPED

Post-translational modifications: 

  • Phosphorylation favors cytoplasmic localization1
  • Ubiquitination2 at Lys59, Lys64, Lys82
  • Modification sites at PhosphoSitePlus

  • See HMGN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005508.1  
    ENSEMBL proteins: 
     ENSP00000355228  

    HMGN2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HMGN2
    GenScript Custom Purified and Recombinant Proteins Services for HMGN2
    Novus Biologicals HMGN2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    HMGN2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HMGN2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for HMGN2 
    OriGene Antibodies for HMGN2
    OriGene Custom Antibody Services for HMGN2
    Novus Biologicals HMGN2 Antibodies
    Search for Antibodies for HMGN2 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for HMGN2
    LSBio Antibodies in human, mouse, rat for HMGN2

    HMGN2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HMGN2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HMGN2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HMG: High-mobility group / Canonical

    1 InterPro protein domain:
     IPR000079 HMGN_fam

    Graphical View of Domain Structure for InterPro Entry P05204

    ProtoNet protein and cluster: P05204

    1 Blocks protein domain: IPB000079 High mobility group protein HMG14 and HMG17

    UniProtKB/Swiss-Prot: HMGN2_HUMAN, P05204
    Similarity: Belongs to the HMGN family


    HMGN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMGN2_HUMAN, P05204
    Function: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the
    histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin
    conformation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0031492nucleosomal DNA binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    HMGN2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HMGN2:
     Decreased Hepatitis C virus re  Synthetic lethal with Ras  Wnt reporter downregulated 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Hmgn2):
     mortality/aging 

    HMGN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hmgn2tm1Mbus for HMGN2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HMGN2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HMGN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HMGN2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HMGN2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HMGN2:
    hsa-mir-455-3p (MIRT037872), hsa-mir-23a-3p (MIRT007264), hsa-mir-30c-5p (MIRT047960), hsa-mir-30b-5p (MIRT046143), hsa-let-7a-5p (MIRT052523)

    Block miRNA regulation of human, mouse, rat HMGN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HMGN2 (see all 64):
    hsa-miR-548j hsa-miR-607 hsa-miR-300 hsa-miR-371-5p hsa-miR-4267 hsa-miR-3916 hsa-miR-3161 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidHMGN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HMGN2
    Predesigned siRNA for gene silencing in human, mouse, rat HMGN2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HMGN2

    Clone
    Products:
         
    OriGene clones in human, mouse for HMGN2 (see all 7)
    OriGene ORF clones in mouse, rat for HMGN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HMGN2 (NM_005517)
    Sino Biological Human cDNA Clone for HMGN2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMGN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGN2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HMGN2
    Browse ESI BIO Cell Lines and PureStem Progenitors for HMGN2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HMGN2_HUMAN, P05204: Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    HMGN2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HMGN2 About    
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Histone modification0.31
    2Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HMGN2
        Chromatin Regulation / Acetylation




    HMGN2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including HMGN2: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HMGN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for HMGN2 (P052041, 2, 3 ENSP000003552284) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202038 I2D: score=1 STRING: ENSP00000250416
    GRB2P629931, 3, ENSP000003390074EBI-1758689,EBI-401755 I2D: score=2 STRING: ENSP00000339007
    DEFB4AO152633I2D: score=1 
    DEFB4BO152633I2D: score=1 
    HMGN1P051143, ENSP000003701254I2D: score=1 STRING: ENSP00000370125
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization ----
    GO:0006355regulation of transcription, DNA-templated ----

    HMGN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HMGN2

    1 Novoseek inferred chemical compound relationship for HMGN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 25 1 8512325 (1)



    HMGN2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HMGN2 gene: 
    NM_005517.3  

    Unigene Cluster for HMGN2:

    High mobility group nucleosomal binding domain 2
    Hs.181163  [show with all ESTs]
    Unigene Representative Sequence: BC110390
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468388 ENST00000479815 ENST00000460563 ENST00000464888 ENST00000463817
    ENST00000467700 ENST00000361427(uc001bmp.4) ENST00000466194 ENST00000493418

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HMGN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HMGN2 (see all 64):
    hsa-miR-548j hsa-miR-607 hsa-miR-300 hsa-miR-371-5p hsa-miR-4267 hsa-miR-3916 hsa-miR-3161 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidHMGN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HMGN2
    Predesigned siRNA for gene silencing in human, mouse, rat HMGN2
    Clone
    Products:
         
    OriGene clones in human, mouse for HMGN2 (see all 7)
    OriGene ORF clones in mouse, rat for HMGN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HMGN2 (NM_005517)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMGN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGN2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HMGN2
    OriGene qSTAR qPCR primer pairs in human, mouse for HMGN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HMGN2
      QuantiTect SYBR Green Assays in human, mouse, rat HMGN2
      QuantiFast Probe-based Assays in human, mouse, rat HMGN2

    Additional mRNA sequence: 

    AK026562.1 BC000378.1 BC003050.1 BC003689.1 BC007124.1 BC014644.1 BC020307.1 BC032140.2 
    BC061898.1 BC064347.1 BC070297.1 BC071707.1 BC072010.1 BC072011.1 BC075837.1 BC081567.1 
    BC110390.1 CR542122.1 M12623.1 

    Selected DOTS entries (see all 76):

    DT.86842062  DT.40118469  DT.100862834  DT.100045613  DT.95262814  DT.91778606  DT.100643383  DT.100745981 
    DT.91778691  DT.120725281  DT.91921666  DT.102839546  DT.120839036  DT.121429741  DT.95301083  DT.100805637 
    DT.120725345  DT.121429574  DT.121429713  DT.100045616  DT.121429686  DT.121429744  DT.95262788  DT.102843751 

    Selected AceView cDNA sequences (see all 1927):

    AA306833 BM756938 CR609228 CD108971 CR608465 AA349411 BM710810 BM543420 
    BQ673616 BM470522 CR606135 BQ643772 BU527115 CR605166 BM453848 AA311894 
    AI628845 AV714549 BQ221931 BM848567 BQ669259 BQ672717 BF436816 BM795332 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HMGN2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5
    SP1:                          -           -                           
    SP2:                                      -                           
    SP3:                          -                                       
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for HMGN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HMGN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HMGN2 Expression
    About this image


    HMGN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             Olfactory Bulb   
     
     Spinal Cord (Nervous System)
    HMGN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMGN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.181163
        Pathway & Disease-focused RT2 Profiler PCR Array including HMGN2: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HMGN2
    OriGene qSTAR qPCR primer pairs in human, mouse for HMGN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HMGN2
    QuantiTect SYBR Green Assays in human, mouse, rat HMGN2
    QuantiFast Probe-based Assays in human, mouse, rat HMGN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HMGN2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmgn25 high mobility group nucleosomal binding domain 2   --   4 (66.47 cM) 133964738 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.66692 Transcribed sequence with moderate similarity to protein more 80.57(n)    141993119 


    ENSEMBL Gene Tree for HMGN2 (if available)
    TreeFam Gene Tree for HMGN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HMGN2 gene
    HMGN42  
    1 SIMAP similar gene for HMGN2 using alignment to 2 protein entries:     HMGN2_HUMAN (see all proteins):
    HMGN4

    HMGN2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HMGN2
    PGOHUM00000258739 PGOHUM00000259027


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HMGN2 (see all 126)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24943921,2
    C,F--26798340(-) GGGAGA/CCTTTC 1 -- us2k15Minor allele frequency- C:0.04EA NA CSA 1629
    rs1862273331,2
    --26798381(+) CCGTCA/TTTCAG 1 -- us2k10--------
    rs24943911,2
    C,F,A,H--26798478(-) ACGCCG/AAAGTG 1 -- us2k1 tfbs322Minor allele frequency- A:0.16MN EA NS NA WA CSA 1503
    rs67038721,2
    C,F,A,H--26798644(+) CGCACG/TGCTTG 1 -- us2k118Minor allele frequency- T:0.09NS EA NA WA 2342
    rs342653451,2
    C--26798807(+) CCCCTC/G/TGGCGC 1 -- us2k10--------
    rs562789521,2
    C--26798831(+) CACTA-/ACCCCC 1 -- us2k10--------
    rs11417811,2
    --26799066(+) CCGCGA/C/TCCAGC 2 -- ut51 ese30--------
    rs1418416151,2
    --26799157(+) CCACT-/GCC   
      GCCACC
    GCCGC
    1 -- int10--------
    rs1916886211,2
    --26799168(+) ACCGCC/TGCCGC 1 -- int10--------
    rs1839649141,2
    --26799334(+) CGCGGC/GGGGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for HMGN2 (26798902 - 26803133 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HMGN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv202n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HMGN2
    DNA2.0 Custom Variant and Variant Library Synthesis for HMGN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 163910    OMIM disorders: --

    13 diseases for HMGN2:    
    About MalaCards
    glucagonoma    primary pulmonary hypertension    scleroderma    burkitt's lymphoma
    colon adenocarcinoma    hypertension    lupus erythematosus    adenoma
    adenocarcinoma    thyroiditis    hiv-1    endotheliitis
    cerebritis


    HMGN2 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for HMGN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chromosomal aberrations 11.1 1 10640150 (1)
    lupus erythematosus systemic 8.96 1 8037838 (1)
    tumors 0 1 2169420 (1)


    Export disorders for HMGN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HMGN2 gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with HMGN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The CEPH consortium linkage map of human chromosome 1. (PubMed id 2037294)1, 3 Dracopoli N.C....Mishra S.K. (Genomics 1991)
    4. Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. Identification of the human high mobility group I-C protein. (PubMed id 2040281)1, 2 Giancotti V....Goodwin G.H. (Eur. J. Biochem. 1991)
    5. Human non-histone chromosomal protein HMG-17: identification, characterization, chromosome localization and RFLPs of a functional gene from the large multigene family. (PubMed id 2565024)1, 2 Landsman D.... Bustin M. (Nucleic Acids Res. 1989)
    6. Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family. (PubMed id 3754870)1, 2 Landsman D.... Bustin M. (J. Biol. Chem. 1986)
    7. Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes. (PubMed id 10207070)1, 9 Herrera J.E....Bustin M. (Mol. Cell. Biol. 1999)
    8. Regional fine mapping of HMG17 to chromosomal band 1p35. (PubMed id 10640150)1, 9 Kazmierczak B....Bullerdiek J. (Cancer Genet. Cytogenet. 2000)
    9. Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores. (PubMed id 7563062)1, 9 Postnikov Y.V....Bustin M. (J. Mol. Biol. 1995)
    10. HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility. (PubMed id 19524541)1, 9 Rattner B.P....Kadonaga J.T. (Mol. Cell 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3151 HGNC: 4986 AceView: HMGN2 Ensembl:ENSG00000198830 euGenes: HUgn3151
    ECgene: HMGN2 H-InvDB: HMGN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HMGN2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HMGN2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HMGN2 gene:
    Search GeneIP for patents involving HMGN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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