Aliases for HMGN2 Gene
Aliases for HMGN2 Gene
- High Mobility Group Nucleosomal Binding Domain 2 2 3 5
- High Mobility Group Nucleosome-Binding Domain-Containing Protein 2 3 4
- High-Mobility Group (Nonhistone Chromosomal) Protein 17 2 3
- HMG17 3 4
- High-Mobility Group Nucleosomal Binding Domain 2 2
- Non-Histone Chromosomal Protein HMG-17 3
- Nonhistone Chromosomal Protein HMG-17 3
- High Mobility Group Protein N2 3
External Ids for HMGN2 Gene
- HGNC: 4986
- Entrez Gene: 3151
- Ensembl: ENSG00000198830
- OMIM: 163910
- UniProtKB: P05204
Previous HGNC Symbols for HMGN2 Gene
- HMG17
Previous GeneCards Identifiers for HMGN2 Gene
- GC01M028726
- GC01P025819
- GC01P026031
- GC01P026404
- GC01P026406
- GC01P026671
- GC01P026800
- GC01P025053
Summaries for HMGN2 Gene
-
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]
GeneCards Summary for HMGN2 Gene
HMGN2 (High Mobility Group Nucleosomal Binding Domain 2) is a Protein Coding gene. Diseases associated with HMGN2 include Limited Scleroderma. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include poly(A) RNA binding and nucleosomal DNA binding. An important paralog of this gene is HMGN4.
UniProtKB/Swiss-Prot for HMGN2 Gene
-
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGN2 Gene
Genomics for HMGN2 Gene
Regulatory Elements for HMGN2 Gene
Enhancers for HMGN2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HMGN2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HMGN2 gene promoter:
Regulatory Element Products
Genomic Location for HMGN2 Gene
- Chromosome:
- 1
- Start:
- 26,472,411 bp from pter
- End:
- 26,476,642 bp from pter
- Size:
- 4,232 bases
- Orientation:
- Plus strand
Genomic View for HMGN2 Gene
Genes around HMGN2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.11 by Ensembl
- 1p36.11 by Entrez Gene
- 1p36.11 by HGNC
HMGN2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMGN2 Gene
Proteins for HMGN2 Gene
-
Protein details for HMGN2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05204-HMGN2_HUMAN
- Recommended name:
- Non-histone chromosomal protein HMG-17
- Protein Accession:
- P05204
- Q0VGD5
- Q6FGI5
- Q96C64
Protein attributes for HMGN2 Gene
- Size:
- 90 amino acids
- Molecular mass:
- 9393 Da
- Quaternary structure:
- No Data Available
Protein Expression for HMGN2 Gene
Post-translational modifications for HMGN2 Gene
- Phosphorylation favors cytoplasmic localization.
- Ubiquitination at isoforms=59, isoforms=64, and posLast=8282
- Modification sites at PhosphoSitePlus
Other Protein References for HMGN2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HMGN2
- Cell Signaling Technology (CST) Antibodies for HMGN2 (HMGN2)
-
Custom Antibody ServicesOriGene Antibodies for HMGN2
- Novus Biologicals Antibodies for HMGN2
-
Cloud-Clone Corp. Antibodies for HMGN2
- Invitrogen Antibodies for HMGN2
- antibodies-online Antibodies for HMGN2: See all 72
- GeneTex HMGN2 antibody for HMGN2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HMGN2
- Origene Custom Protein Services for HMGN2
- Novus Biologicals proteins for HMGN2
-
Cloud-Clone Corp. Proteins for HMGN2
- antibodies-online Proteins for HMGN2: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HMGN2
Assay Products
- antibodies-online Kits for HMGN2: See all 21
No data available for DME Specific Peptides for HMGN2 Gene
Domains & Families for HMGN2 Gene
Gene Families for HMGN2 Gene
Protein Domains for HMGN2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMGN2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P05204- Family:
-
- Belongs to the HMGN family.
Function for HMGN2 Gene
Molecular function for HMGN2 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | IDA | 22681889 |
| GO:0005515 | protein binding | IPI | 21044950 |
| GO:0031492 | nucleosomal DNA binding | IEA | -- |
Phenotypes for HMGN2 Gene
- GenomeRNAi human phenotypes for HMGN2:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Decreased NF-kappaB reporter expression
- Increased shRNA abundance (Z-score > 2)
- Wnt reporter downregulated
- Decreased Hepatitis C virus replication
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGN2 gene
-
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- Search ViGene Biosciences for HMGN2
CRISPR Products
-
OriGene CRISPR knockouts for HMGN2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGN2
- GenScript: Design CRISPR guide RNA sequences for HMGN2
miRNA for HMGN2 Gene
- miRTarBase miRNAs that target HMGN2
-
- hsa-mir-23a-3p (MIRT007264)
- hsa-mir-455-3p (MIRT037872)
- hsa-mir-30b-5p (MIRT046143)
- hsa-mir-30c-5p (MIRT047960)
- hsa-let-7a-5p (MIRT052523)
- hsa-mir-559 (MIRT248628)
- hsa-mir-548b-5p (MIRT248629)
- hsa-mir-548a-5p (MIRT248630)
- hsa-mir-548c-5p (MIRT248631)
- hsa-mir-548d-5p (MIRT248632)
- hsa-mir-548j-5p (MIRT248633)
- hsa-mir-548n (MIRT248634)
- hsa-mir-548h-5p (MIRT248635)
- hsa-mir-548i (MIRT248636)
- hsa-mir-548w (MIRT248637)
- hsa-mir-548y (MIRT248638)
- hsa-mir-548o-5p (MIRT248639)
- hsa-mir-548ab (MIRT248640)
- hsa-mir-548ad-5p (MIRT248641)
- hsa-mir-548ae-5p (MIRT248642)
- hsa-mir-548ak (MIRT248643)
- hsa-mir-548am-5p (MIRT248644)
- hsa-mir-548ap-5p (MIRT248646)
- hsa-mir-548aq-5p (MIRT248647)
- hsa-mir-548ar-5p (MIRT248648)
- hsa-mir-548as-5p (MIRT248649)
- hsa-mir-548au-5p (MIRT248650)
- hsa-mir-548ay-5p (MIRT248651)
- hsa-mir-548bb-5p (MIRT248653)
- hsa-mir-153-5p (MIRT338906)
- hsa-mir-548a-3p (MIRT338907)
- hsa-mir-548e-3p (MIRT338908)
- hsa-mir-548f-3p (MIRT338909)
- hsa-mir-548ar-3p (MIRT338912)
- hsa-mir-5582-3p (MIRT338913)
- hsa-mir-548az-3p (MIRT338914)
- hsa-mir-1253 (MIRT338915)
- hsa-mir-3688-3p (MIRT338917)
- hsa-mir-4434 (MIRT338918)
- hsa-mir-4516 (MIRT338919)
- hsa-mir-3978 (MIRT338920)
- hsa-mir-4728-3p (MIRT338921)
- hsa-mir-5004-5p (MIRT338922)
- hsa-mir-5197-3p (MIRT338923)
- hsa-mir-5681a (MIRT338924)
- hsa-mir-5703 (MIRT338925)
- hsa-mir-6760-5p (MIRT338926)
- hsa-mir-6878-5p (MIRT338927)
- hsa-mir-599 (MIRT450851)
- hsa-mir-544a (MIRT450852)
- hsa-mir-3161 (MIRT450853)
- hsa-mir-20a-3p (MIRT450854)
- hsa-mir-3163 (MIRT450855)
- hsa-mir-340-5p (MIRT450856)
- hsa-mir-2115-3p (MIRT485490)
- hsa-mir-548ay-3p (MIRT485491)
- hsa-mir-548at-3p (MIRT485492)
- hsa-mir-548as-3p (MIRT485493)
- hsa-mir-548t-3p (MIRT485494)
- hsa-mir-548ap-3p (MIRT485495)
- hsa-mir-548aa (MIRT485496)
- hsa-mir-548c-3p (MIRT485497)
- hsa-mir-3202 (MIRT511499)
- hsa-mir-1264 (MIRT511500)
- hsa-mir-3184-3p (MIRT511501)
- hsa-mir-7-2-3p (MIRT511502)
- hsa-mir-7-1-3p (MIRT511503)
- hsa-mir-548x-3p (MIRT511504)
- hsa-mir-548j-3p (MIRT511505)
- hsa-mir-548aq-3p (MIRT511506)
- hsa-mir-548am-3p (MIRT511507)
- hsa-mir-548aj-3p (MIRT511508)
- hsa-mir-548ah-3p (MIRT511509)
- hsa-mir-548ae-3p (MIRT511510)
- hsa-mir-548z (MIRT511511)
- hsa-mir-548h-3p (MIRT511512)
- hsa-mir-548d-3p (MIRT511513)
- hsa-mir-548bb-3p (MIRT511514)
- hsa-mir-548ac (MIRT511515)
- hsa-mir-1261 (MIRT536814)
- hsa-mir-1266-3p (MIRT536815)
- hsa-mir-890 (MIRT536816)
- hsa-mir-10b-5p (MIRT536817)
- hsa-mir-10a-5p (MIRT536818)
- hsa-mir-504-5p (MIRT536820)
- hsa-mir-4668-5p (MIRT542931)
- hsa-mir-208b-5p (MIRT542932)
- hsa-mir-208a-5p (MIRT542933)
- hsa-mir-607 (MIRT562207)
- hsa-mir-6715b-3p (MIRT562208)
- hsa-mir-205-3p (MIRT562209)
- hsa-mir-587 (MIRT567307)
- hsa-mir-4477a (MIRT567308)
- hsa-mir-3713 (MIRT567309)
- hsa-mir-4267 (MIRT567310)
- hsa-mir-5586-5p (MIRT567311)
- hsa-mir-548g-3p (MIRT567312)
miRNA Products
- Search ViGene Biosciences for HMGN2
Inhibitory RNA Products
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for HMGN2
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMGN2 Gene
Localization for HMGN2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMGN2 Gene
- Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IEA | -- |
| GO:0005615 | extracellular space | IDA | 16204630 |
| GO:0005634 | nucleus | IDA,IEA | 16204630 |
| GO:0005737 | cytoplasm | IDA,IEA | 16204630 |
Pathways & Interactions for HMGN2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin Regulation / Acetylation | ||
Pathways by source for HMGN2 Gene
1 Cell Signaling Technology pathway for HMGN2 Gene
Interacting Proteins for HMGN2 Gene
Selected Interacting proteins:
P05204-HMGN2_HUMAN
ENSP00000355228
for HMGN2 Gene via
IID
UniProtKB
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0031640 | killing of cells of other organism | IMP | 16204630 |
Transcripts for HMGN2 Gene
mRNA/cDNA for HMGN2 Gene
- (1) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (1927) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HMGN2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HMGN2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGN2
- GenScript: Design CRISPR guide RNA sequences for HMGN2
miRNA Products
- Search ViGene Biosciences for HMGN2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMGN2
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-
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Clone Products
-
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | |||||||||||||||||||||
| SP5: |
Expression for HMGN2 Gene
This gene is overexpressed in Stomach (23.0), Peripheral blood mononuclear cells (18.4), and Urine (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMGN2 Gene
NURSA nuclear receptor signaling pathways regulating expression of HMGN2 Gene:
HMGN2SOURCE GeneReport for Unigene cluster for HMGN2 Gene:
Hs.181163Evidence on tissue expression from TISSUES for HMGN2 Gene
- Blood(4.7)
- Lung(4.7)
- Nervous system(4.7)
- Eye(4.5)
- Liver(4.3)
- Skin(4.3)
- Intestine(4.1)
- Pancreas(3.9)
- Muscle(3.7)
- Kidney(3.4)
- Bone(3.3)
- Bone marrow(2.5)
- Lymph node(2.3)
- Stomach(2.3)
- Spleen(2.1)
- Adrenal gland(2)
- Heart(2)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for HMGN2
-
OriGene qPCR primer pairs for HMGN2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGN2 Gene
Orthologs for HMGN2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMGN2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
ManyToMany | |
| mouse (Mus musculus) |
Mammalia | Gm6594 35 |
|
ManyToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.6669 34 |
|
- Species where no ortholog for HMGN2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HMGN2 Gene
(1) SIMAP similar genes for HMGN2 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for HMGN2 Gene
Variants for HMGN2 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1055323 | Likely benign | 26,471,163(+) | CAAGC(C/T)AGGTT | upstream-variant-2KB, utr-variant-3-prime | |
| rs12096239 | Likely benign | 26,470,431(+) | CATGA(C/G)CCACC | upstream-variant-2KB, utr-variant-3-prime | |
| rs2290588 | Likely benign | 26,471,017(-) | CCTGT(A/G)TACCT | upstream-variant-2KB, utr-variant-3-prime | |
| rs1057515473 | Uncertain significance | 26,471,126(+) | TAGAA(C/T)TCGTG | upstream-variant-2KB, utr-variant-3-prime | |
| rs1057515508 | Uncertain significance | 26,470,836(+) | GCAGA(A/G)CCCTA | upstream-variant-2KB, utr-variant-3-prime |
Residual Variation Intolerance Score:
44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.03;
0.72% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HMGN2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HMGN2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGN2 Gene
Disorders for HMGN2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| limited scleroderma |
|
|
Search HMGN2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HMGN2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HMGN2
No data available for UniProtKB/Swiss-Prot and Genatlas for HMGN2 Gene
Publications for HMGN2 Gene
- Serine ADP-ribosylation depends on HPF1. (PMID: 28190768) Bonfiglio J.J. … Matic I. (Mol. Cell 2017) 3 4 64
- HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility. (PMID: 19524541) Rattner B.P. … Kadonaga J.T. (Mol. Cell 2009) 3 22 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Regional fine mapping of HMG17 to chromosomal band 1p35. (PMID: 10640150) Kazmierczak B. … Bullerdiek J. (Cancer Genet. Cytogenet. 2000) 3 22 64
Products for HMGN2 Gene
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- antibodies-online Antibodies for HMGN2: See all 72
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- antibodies-online Proteins for HMGN2: See all 10
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- GeneTex HMGN2 antibody for HMGN2
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- ViGene Biosciences adenoviral particle packaged cDNA for HMGN2 gene
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- Horizon Cell Lines for HMGN2
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- VectorBuilder custom plasmid, inducible vectors for HMGN2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HMGN2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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