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Aliases for HMGN1 Gene

Aliases for HMGN1 Gene

  • High Mobility Group Nucleosome Binding Domain 1 2 3
  • HMG14 3 4 6
  • High Mobility Group Nucleosome-Binding Domain-Containing Protein 1 3 4
  • High-Mobility Group (Nonhistone Chromosomal) Protein 14 2 3
  • High-Mobility Group Nucleosome Binding Domain 1 2 3
  • High-Mobility Group Nucleosome Binding 1 2 3
  • Nonhistone Chromosomal Protein HMG-14 2 3
  • Non-Histone Chromosomal Protein HMG-14 3

External Ids for HMGN1 Gene

Previous Symbols for HMGN1 Gene

  • HMG14

Summaries for HMGN1 Gene

Entrez Gene Summary for HMGN1 Gene

  • The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]

GeneCards Summary for HMGN1 Gene

HMGN1 (High Mobility Group Nucleosome Binding Domain 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and Chromatin Regulation / Acetylation. GO annotations related to this gene include nucleosomal DNA binding.

UniProtKB/Swiss-Prot for HMGN1 Gene

  • Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).

Gene Wiki entry for HMGN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGN1 Gene

Genomics for HMGN1 Gene

Genomic Location for HMGN1 Gene

Start:
39,342,315 bp from pter
End:
39,349,647 bp from pter
Size:
7,333 bases
Orientation:
Minus strand

Genomic View for HMGN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMGN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGN1 Gene

Regulatory Elements for HMGN1 Gene

Proteins for HMGN1 Gene

  • Protein details for HMGN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05114-HMGN1_HUMAN
    Recommended name:
    Non-histone chromosomal protein HMG-14
    Protein Accession:
    P05114
    Secondary Accessions:
    • Q3KQR8

    Protein attributes for HMGN1 Gene

    Size:
    100 amino acids
    Molecular mass:
    10659 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HMGN1 Gene

Proteomics data for HMGN1 Gene at MOPED

Post-translational modifications for HMGN1 Gene

  • Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys5 and Lys14

No data available for DME Specific Peptides for HMGN1 Gene

Domains for HMGN1 Gene

Gene Families for HMGN1 Gene

HGNC:
  • HMG :High-mobility group / Canonical

Protein Domains for HMGN1 Gene

UniProtKB/Swiss-Prot:

HMGN1_HUMAN
Family:
  • Belongs to the HMGN family.:
    • P05114
genes like me logo Genes that share domains with HMGN1: view

Function for HMGN1 Gene

Molecular function for HMGN1 Gene

UniProtKB/Swiss-Prot Function: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).

Gene Ontology (GO) - Molecular Function for HMGN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 8047885
GO:0003682 chromatin binding --
GO:0031492 nucleosomal DNA binding IEA --
genes like me logo Genes that share ontologies with HMGN1: view
genes like me logo Genes that share phenotypes with HMGN1: view

Animal Models for HMGN1 Gene

MGI Knock Outs for HMGN1:

miRNA for HMGN1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HMGN1 Gene

Localization for HMGN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGN1 Gene

Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMGN1 Gene COMPARTMENTS Subcellular localization image for HMGN1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HMGN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HMGN1: view

Pathways for HMGN1 Gene

genes like me logo Genes that share pathways with HMGN1: view

Pathways by source for HMGN1 Gene

1 Qiagen pathway for HMGN1 Gene
1 Cell Signaling Technology pathway for HMGN1 Gene
1 BioSystems pathway for HMGN1 Gene
1 KEGG pathway for HMGN1 Gene

Gene Ontology (GO) - Biological Process for HMGN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000720 pyrimidine dimer repair by nucleotide-excision repair IEA --
GO:0006283 transcription-coupled nucleotide-excision repair IEA --
GO:0006325 chromatin organization IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0010224 response to UV-B IEA --
genes like me logo Genes that share ontologies with HMGN1: view

Compounds for HMGN1 Gene

(3) Novoseek inferred chemical compound relationships for HMGN1 Gene

Compound -log(P) Hits PubMed IDs
anisomycin 69.7 1
okadaic acid 34.1 2
serine 18.6 3
genes like me logo Genes that share compounds with HMGN1: view

Transcripts for HMGN1 Gene

Unigene Clusters for HMGN1 Gene

High mobility group nucleosome binding domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMGN1 Gene

No ASD Table

Relevant External Links for HMGN1 Gene

GeneLoc Exon Structure for
HMGN1
ECgene alternative splicing isoforms for
HMGN1

Expression for HMGN1 Gene

mRNA expression in normal human tissues for HMGN1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMGN1 Gene

SOURCE GeneReport for Unigene cluster for HMGN1 Gene Hs.356285

genes like me logo Genes that share expressions with HMGN1: view

Orthologs for HMGN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMGN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMGN1 36
  • 99.67 (n)
  • 100 (a)
HMGN1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 83 (a)
OneToMany
HMGN1 36
  • 90.33 (n)
  • 96 (a)
HMGN1 37
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HMGN1 36
  • 92.67 (n)
  • 97 (a)
HMGN1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmgn1 36
  • 81.05 (n)
  • 85.26 (a)
Hmgn1 16
Hmgn1 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 74 (a)
OneToMany
-- 37
  • 74 (a)
OneToMany
-- 37
  • 75 (a)
OneToMany
-- 37
  • 68 (a)
OneToMany
-- 37
  • 67 (a)
OneToMany
-- 37
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HMGN1 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmgn1 36
  • 80.35 (n)
  • 85.26 (a)
chicken
(Gallus gallus)
Aves HMGN1 36
  • 72.57 (n)
  • 68.75 (a)
HMGN1 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HMGN1 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hmgn1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75785 36
Species with no ortholog for HMGN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HMGN1 Gene

ENSEMBL:
Gene Tree for HMGN1 (if available)
TreeFam:
Gene Tree for HMGN1 (if available)

Paralogs for HMGN1 Gene

Selected SIMAP similar genes for HMGN1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with HMGN1: view

No data available for Paralogs for HMGN1 Gene

Variants for HMGN1 Gene

Sequence variations from dbSNP and Humsavar for HMGN1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs741795 -- 39,346,514(-) CCAAG(A/G)TATTA intron-variant
rs760166 -- 39,346,235(+) TAACA(C/T)GGGCG intron-variant
rs914156 -- 39,345,552(+) GGTCC(A/C)CCCCA intron-variant
rs1474490 -- 39,344,210(+) aagat(A/C)ccacc intron-variant
rs1474491 -- 39,344,382(+) ATCAA(A/C)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMGN1 Gene

Variant ID Type Subtype PubMed ID
nsv913744 CNV Loss 21882294

Relevant External Links for HMGN1 Gene

HapMap Linkage Disequilibrium report
HMGN1

Disorders for HMGN1 Gene

(1) University of Copenhagen DISEASES for HMGN1 Gene

(2) Novoseek inferred disease relationships for HMGN1 Gene

Disease -log(P) Hits PubMed IDs
down syndrome 29.8 4
breast cancer 0 1
genes like me logo Genes that share disorders with HMGN1: view

No data available for UniProtKB/Swiss-Prot for HMGN1 Gene

Publications for HMGN1 Gene

  1. Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry. (PMID: 10739259) Louie D.F. … Ahn N.G. (Protein Sci. 2000) 3 4 23
  2. Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family. (PMID: 2563381) Landsman D. … Bustin M. (J. Biol. Chem. 1989) 2 3 4
  3. Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family. (PMID: 3782107) Landsman D. … Bustin M. (J. Biol. Chem. 1986) 2 3 4
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  5. Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins. (PMID: 12215538) Prymakowska-Bosak M. … Bustin M. (Mol. Cell. Biol. 2002) 3 23

Products for HMGN1 Gene

Sources for HMGN1 Gene

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