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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HMGN1 Gene

protein-coding   GIFtS: 55
GCID: GC21M040714

high mobility group nucleosome binding domain 1

(Previous names: high-mobility group (nonhistone chromosomal) protein 14,...)
(Previous symbol: HMG14)
 Explore 4 diseases affiliated with
HMGN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HMGN1    

Aliases
for HMGN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
High Mobility Group Nucleosome Binding Domain 11 2     FLJ314711
HMG141 2 3 5     MGC1042301
High-Mobility Group (Nonhistone Chromosomal) Protein 141 2     MGC1174251
High-Mobility Group Nucleosome Binding Domain 11 2     High-Mobility Group Nucleosome Binding 12
High Mobility Group Nucleosome-Binding Domain-Containing Protein 12 3     Non-Histone Chromosomal Protein HMG-142
FLJ272651     Nonhistone Chromosomal Protein HMG-142

External Ids:    HGNC: 49841   Entrez Gene: 31502   Ensembl: ENSG000002055817   OMIM: 1639205   UniProtKB: P051143   

Export aliases for HMGN1 gene to outside databases

Previous GC identifers: GC21M037290 GC21M039634 GC21M039637 GC21M026182


Summaries
for HMGN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HMGN1:
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along
with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around
transcribable genes. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: HMGN1_HUMAN, P05114
Function: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone
octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation.
Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity)

Gene Wiki entry for HMGN1


Genomic Views
for HMGN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HMGN1 gene promoter:
         SRF   TBP   FOXF2   SRF (504 AA)   FOXD3   HNF-4alpha2   AREB6   TFIID   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HMGN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HMGN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMGN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.2   Ensembl cytogenetic band:  21q22.2   HGNC cytogenetic band: 21q22.3

HMGN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMGN1 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M040714:  view genomic region     (about GC identifiers)

Start:
 40,714,241 bp from pter      End:
 40,721,573 bp from pter
Size:
 7,333 bases      Orientation:
 minus strand

Proteins
for HMGN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HMGN1_HUMAN, P05114 (See protein sequence)
Recommended Name: Non-histone chromosomal protein HMG-14  
Size: 100 amino acids; 10659 Da
Subcellular location: Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version
localizes to the nucleus
Rna editing: Modified_positions=Not_applicable; Note=Partially edited. A new initiator methionine may be created by a
single uridine insertion in the 5'-UTR, causing an N-terminal extension of 45 amino acids. The existence of the RNA
edited version is supported by direct protein sequencing by MS/MS of the following peptides specific to that version:
23-31 and 40-48. The RNA edited version is called ET-HMGN1
Mass spectrometry: Mass=10527.8; Mass_error=0.7; Method=Electrospray; Range=2-100; Source=PubMed:10739259;
Mass spectrometry: Mass=10608; Method=Electrospray; Range=2-100; Source=PubMed:10739259;
Mass spectrometry: Mass=10688; Mass_error=1.3; Method=Electrospray; Range=2-100; Source=PubMed:10739259;
Mass spectrometry: Mass=10768; Method=Electrospray; Range=2-100; Source=PubMed:10739259;
Secondary accessions: Q3KQR8

Explore the universe of human proteins at neXtProt for HMGN1: NX_P05114

Post-translational modifications:

  • Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By
    • similarity). Phosphorylation favors cytoplasmic localization1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P05114

    • HMGN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004956.5  
    ENSEMBL proteins: 
     ENSP00000288344   ENSP00000395291   ENSP00000370125   ENSP00000414421   ENSP00000370124  
     ENSP00000396693   ENSP00000370123   ENSP00000395787   ENSP00000355293  

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    OriGene Protein Over-expression Lysate: HMGN1
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    Novus Biologicals HMGN1 Proteins
    Novus Biologicals HMGN1 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for HMGN1
    Uscn Proteins for HMGN1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005634nucleus IDA16780588
    GO:0005737cytoplasm IEA--


    HMGN1 for ontologies           About GeneDecksing



    HMGN1 Antibody Products: 
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    Uscn Antibodies for HMGN1
    ThermoFisher Antibodies for HMGN1

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    Uscn ELISAs and CLIAs for HMGN1

    Protein Domains /
    Families
    for HMGN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HMGN1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000079 HMGN_fam

    Graphical View of Domain Structure for InterPro Entry P05114

    ProtoNet protein and cluster: P05114

    1 Blocks protein family: IPB000079 High mobility group protein HMG14 and HMG17

    UniProtKB/Swiss-Prot: HMGN1_HUMAN, P05114
    Similarity: Belongs to the HMGN family


    Function
    for HMGN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HMGN1_HUMAN, P05114
    Function: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone
    octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation.
    Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity)

    miRNA
    Products:            		miRTarBase miRNAs that target HMGN1:
    hsa-mir-197 (MIRT004185)

    OriGene 3'-UTR Clone: HMGN1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HMGN1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HMGN1 (see all 16):
    hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-181a-2* hsa-miR-3161 hsa-let-7g* hsa-miR-548x hsa-miR-613 hsa-miR-33b
    SwitchGear 3'UTR luciferase reporter plasmid: HMGN1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMGN1 (see all 7)
    OriGene shRNA RFP: HMGN1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMGN1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HMGN1

    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HMGN1 (NM_004965)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMGN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGN1 

    Cell Line
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    Search LifeMap BioReagents cell lines for HMGN1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGN1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS8047885
    GO:0003682chromatin binding ----
    GO:0031492nucleosomal DNA binding IEA--


    HMGN1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for HMGN1:
     Decreased Wnt reporter activit  Increased S DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Hmgn1tm1Mbus for HMGN1
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hmgn1):
     cellular  integument  mortality/aging  tumorigenesis 

    HMGN1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HMGN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Chromatin Regulation / Acetylation
    		Chromatin Regulation / Acetylation1.00
    2p38 MAPK Signaling Pathway
    		p38 MAPK Signaling Pathway1.00
    3Rho Family GTPases
    		ERK Signaling0.61
    4Signal transduction Activin A signaling regulation
    		Histone modification0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for HMGN1
        Histone modification

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HMGN1
        ERK Signaling

    1 Cell Signaling Technology (CST) Pathway for HMGN1
        Chromatin Regulation / Acetylation

    1 BioSystems Pathway for HMGN1 
        p38 MAPK Signaling Pathway



    HMGN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HMGN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for HMGN1 (P051143 ENSP000003701254) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAP176123, ENSP000003095914I2D: score=2 STRING: ENSP00000309591
    ERCC6Q034683, ENSP000003480894I2D: score=1 STRING: ENSP00000348089
    HMGN2P052043, ENSP000003552284I2D: score=1 STRING: ENSP00000355228
    BTG2P785433, ENSP000002905514I2D: score=1 STRING: ENSP00000290551
    EP300Q094723, ENSP000002632534I2D: score=2 STRING: ENSP00000263253
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000720pyrimidine dimer repair by nucleotide-excision repair IEA--
    GO:0006283transcription-coupled nucleotide-excision repair IEA--
    GO:0006325chromatin organization IEA--
    GO:0010224response to UV-B IEA--
    GO:0010225response to UV-C IEA--


    HMGN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HMGN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HMGN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HMGN1
    3 Novoseek chemical compound relationships for HMGN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anisomycin 69.7 2 15327773 (1)
    okadaic acid 34.1 4 10739259 (2)
    serine 18.6 3 15147216 (2), 16729963 (1)

    Search CenterWatch for drugs/clinical trials and news about HMGN1 

    Transcripts
    for HMGN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HMGN1 gene: 
    NM_004965.6  

    Unigene Cluster for HMGN1:

    High mobility group nucleosome binding domain 1
    Hs.356285  [show with all ESTs]
    Unigene Representative Sequence: AK056033
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000288344 ENST00000486741 ENST00000431390 ENST00000380749(uc002yxo.3)
    ENST00000492280(uc021wjh.1) ENST00000436324 ENST00000380748 ENST00000419378
    ENST00000489072 ENST00000482192 ENST00000380747 ENST00000485550 ENST00000490032
    ENST00000443046 ENST00000464078 ENST00000491183 ENST00000479586 ENST00000471260


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HMGN1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HMGN1 (see all 16):
    hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-181a-2* hsa-miR-3161 hsa-let-7g* hsa-miR-548x hsa-miR-613 hsa-miR-33b
    SwitchGear 3'UTR luciferase reporter plasmid: HMGN1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMGN1 (see all 7)
    OriGene shRNA RFP: HMGN1
    OriGene siRNA: HMGN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMGN1
    Clone
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    GenScript: all cDNA clones in your preferred vector: HMGN1 (NM_004965)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMGN1
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    Primer
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    Additional cDNA sequence: 

    AK056033.1 AK130775.1 AK315410.1 BC000075.2 BC023984.1 BC070153.1 BC070154.1 BC071643.1 
    BC072672.1 BC106080.1 BC107741.1 BT007337.1 J02621.1 

    24/45 DOTS entries (see all 45):

    DT.92407831  DT.100667845  DT.453431  DT.100641194  DT.100777072  DT.407720  DT.85104211  DT.100687765 
    DT.92460767  DT.121142587  DT.87015269  DT.102835942  DT.100667842  DT.100867204  DT.100876365  DT.121142550 
    DT.121142563  DT.121142588  DT.95374491  DT.100848559  DT.121142520  DT.100667837  DT.121142552  DT.99965110 

    24/792 AceView cDNA sequences (see all 792):

    AW339693 CR591548 CF128073 BC070153 BU538894 AA164186 BM792962 BX335095 
    BM798857 BE350703 CR597521 H56177 AA954749 AU135660 CR619783 AU133336 
    H25340 BM782087 AW340604 AA165349 CR625629 CR601793 CR616640 BM754855 

    GeneLoc Exon Structure


    Expression
    for HMGN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HMGN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTTTTTAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HMGN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)

    See HMGN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HMGN1

    SOURCE GeneReport for Unigene cluster: Hs.356285
        SABiosciences Custom PCR Arrays for HMGN1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMGN1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGN1

    Orthologs
    for HMGN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HMGN1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HMGN16
    		 high-mobility group nucleosome binding domain 1
    		 65(a)
    		 1 ↔ 1
    		 1(111448474-111454689)
    lizard
    (Anolis carolinensis)    		 Reptilia HMGN16
    		 --
    		 74(a)
    		 1 ↔ 1
    		 3(139707874-139718848)
    African clawed frog
    (Xenopus laevis)    		 Amphibia hmgn1-prov2 high-mobility group nucleosome binding domain 1 80.05(n)    BC054972.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1584096
    si:dkeyp-86f7.36
    		 si:dkeyp-86f7.3
    		 49(a)
    46(a)
    		 many ↔ many
    many ↔ many
    		 5(24752963-24756103)
    14(9593656-9600394)


    ENSEMBL Gene Tree for HMGN1 (if available)
    TreeFam Gene Tree for HMGN1 (if available) 

    Paralogs
    for HMGN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HMGN1 gene
    HMGN22  HMGN32  HMGN42  
    2 SIMAP similar genes for HMGN1 using alignment to 9 protein entries:     HMGN1_HUMAN (see all proteins):
    HMGN5    HMGN3

    HMGN1 for paralogs           About GeneDecksing


    5/47 Pseudogenes.org Pseudogenes for HMGN1 (see all 47)
    PGOHUM00000238683 PGOHUM00000242128 PGOHUM00000242169 PGOHUM00000250397 PGOHUM00000239377


    Genomic Variants
    for HMGN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/258 NCBI SNPs in HMGN1 are shown (see all 258)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1161631911,2
    		--40713753(+) AGGTCT/GATTGC 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs27763061,2
    		C,F,A,--40713754(+) ggtctA/Gttgcc 1 -- ds500110Minor allele frequency- G:0.37NA WA CSA EA 372
    rs1810985191,2
    		--40713769(+) AGCAAC/TAGGTT 1 -- ds50010--------
    rs99742661,2
    		C,F,--40713770(+) GCAATA/GGGTTA 1 -- ds50013Minor allele frequency- G:0.10WA NA EA 358
    rs28547271,2
    		C,F,A,H,--40713787(-) atgtaA/Ggctgt 1 -- ds500122Minor allele frequency- G:0.37NS EA NA WA CSA 2346
    rs27763071,2
    		C,F,A,H,--40713833(+) actctC/Gtatga 1 -- ds500127Minor allele frequency- G:0.24NS EA NA WA CSA 2778
    rs1857456161,2
    		--40713866(+) AACAAC/TGTGTT 1 -- ds50010--------
    rs1893243051,2
    		--40713938(+) CACTTA/CAAAAA 1 -- ds50010--------
    rs757864001,2
    		C,--40713939(+) ACTTAC/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1809560701,2
    		--40713962(+) GATCAA/TATATG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HMGN1 (40714241 - 40721573 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HMGN1: --

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    Prostate Cancer
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    Disorders / Diseases
    for HMGN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HMGN1 for disorders           About GeneDecksing

    OMIM gene information: 163920    OMIM disorders: --

    4 diseases for HMGN1:    About MalaCards
    down syndrome    cockayne syndrome    breast cancer    osteosarcoma

    1 disease from the University of Copenhagen DISEASES database for HMGN1:
    Cockayne syndrome

    2 Novoseek disease relationships for HMGN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 29.8 4 1825298 (2), 2140193 (1), 1360278 (1)
    breast cancer 0 1 15147216 (1)


    Export disorders for HMGN1 gene to outside databases

    Publications
    for HMGN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HMGN1 gene, integrated from 9 sources (see all 82):
    (articles sorted by number of sources associating them with HMGN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family. (PubMed id 2563381)1, 2, 3 Landsman D....Bustin M. (1989)
    2. Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family. (PubMed id 3782107)1, 2, 3 Landsman D.... Bustin M. (1986)
    3. Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry. (PubMed id 10739259)1, 2, 9 Louie D.F....Ahn N.G. (2000)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    6. Aberrant expression of high mobility group chromosomal protein 14 affects cellular differentiation. (PubMed id 8514795)1, 9 Pash J.M....Bustin M. (1993)
    7. Stimulation of RNA polymerase II elongation by chromosomal protein HMG-14. (PubMed id 8047885)1, 9 Ding H.F....Hansen U. (1994)
    8. Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells. (PubMed id 15147216)1, 9 Zou Y....Wang Y. (2004)
    9. Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes. (PubMed id 10753971)1, 9 Bergel M....Bustin M. (2000)
    10. Phosphorylation of human high mobility group N1 protein by protein kinase CK2. (PubMed id 16729963)1, 9 Jiang X.G. and Wang Y. (2006)

    External Searches for HMGN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HMGN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3150 HGNC: 4984 AceView: HMGN1 Ensembl:ENSG00000205581 euGenes: HUgn3150
    ECgene: HMGN1 H-InvDB: HMGN1

    Other Databases showing HMGN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HMGN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HMGN1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HMGN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HMGN1 gene:
    Search GeneIP for patents involving HMGN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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