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HMGA2 Gene

protein-coding   GIFtS: 60

GC12P064504
high mobility group AT-hook 2
(Previous name: high-mobility group (nonhistone chromosomal) protein isoform I-C )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HMGIC)
Services    

Aliases &
Descriptions
for HMGA2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
BABL 1, 2, 5
HMGI-C 2
HMGIC 2, 3, 5
LIPO 1, 2, 5
STQTL9 2
Descriptions
High mobility group AT-hook protein 2 3
High-mobility group protein HMGI-C 2
high mobility group AT-hook 2 2
high-mobility group (nonhistone chromosomal) protein
isoform I-C 1, 2
External Ids
HGNC: 50091
Entrez Gene: 80912
UniProtKB: P529263
Ensembl: ENSG000001499487
Search outside databases for aliases for HMGA2 gene

Previous GC identifers: GC12P065624 GC12P066105 GC12P065934

Summaries
for HMGA2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for HMGA2:
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG)
protein family. HMG proteins function as architectural factors and are essential components of the
enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional
regulating factor. Identification of the deletion, amplification, and rearrangement of this gene
that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal
differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is
involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different
isoforms, have been characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: HMGA2_HUMAN, P52926
Function: Functions as a transcriptional regulator. Functions in cell cycle regulation through
CCNA2

Gene Wiki entry for HMGA2

Genomic Location
for HMGA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the HMGA2 gene  

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q14.3   HGNC cytogenetic band: 12q15

HMGA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P064504:     (about GC identifiers)

Start:
 64,504,507 bp from pter
End:
 64,646,338 bp from pter
Size:
 141,832 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000012.10  NT_029419.11  

Proteins
for HMGA2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: HMGA2_HUMAN, P52926 (See protein sequence)
Recommended Name: High mobility group protein HMGI-C  
Size: 109 amino acids; 11832 Da
Subunit: Interacts with E4F1
Subcellular location: Nucleus
Developmental stage: Expressed predominantly during embryogenesis

Post-translational modifications:

  • Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_003474.1  NP_003475.1  


    ENSEMBL proteins: 
    ENSP00000377206 ENSP00000346658 ENSP00000377205 ENSP00000384026 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (HMGA2)
    Human Recombinant Proteins from Abnova (HMGA2)
                  OriGene Purified Recombinant Human Protein: HMGA2 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228 nuclear chromosome IEA--
    GO:0000785 chromatin IEA--
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for HMGA2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for HMGA2
    R&D Systems Antibodies for HMGA2
    Antibodies from Abcam (HMGA2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (HMGA2)
    Novus Biologicals Antibodies for HMGA2

    Assays for HMGA2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for HMGA2

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR017956 AT_hook_DNA-bd_CS
     IPR000116 Highmoblty_IY
     IPR000637 HMGI/Y_DNA-bd_CS


       GeneDecks  HMGA2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P52926

    ProtoNet protein and cluster: P52926

    1 Blocks protein family: IPB000116 High mobility group protein (HMGY) signature

    UniProtKB/Swiss-Prot: HMGA2_HUMAN, P52926
    Similarity: Belongs to the HMGA family
    Similarity: Contains 3 A.T hook DNA-binding domains

    Gene Function
    for HMGA2

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (HMGA2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (HMGA2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003483

                  Applied Biosystems Silencer® siRNAs for HMGA2

                  Sigma-Aldrich siRNA for HMGA2  
                         Sigma-Aldrich shRNA for HMGA2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003483
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003483
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001015886 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003483

    UniProtKB/Swiss-Prot: HMGA2_HUMAN, P52926
    Function: Functions as a transcriptional regulator. Functions in cell cycle regulation through
    CCNA2

    12 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Hmga2):

    adipose tissuebehavior/neurologicalcraniofacialendocrine/exocrine glandgrowth/size
    hearing/vestibular/earhomeostasis/metabolismlimbs/digits/tailnervous systemno phenotypic analysis
    reproductive systemskin/coat/nails

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0003680 AT DNA binding TAS7606786
    GO:0005515 protein binding IPI16293633
    About this table

    Pathways & Interactions
    for HMGA2

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  HMGA2 


    5/22 Interacting proteins for HMGA2 (ENSP000003466583 P529261) via UniProtKB, MINT, and/or STRING (see all 22 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRMT6Q96LA81STRING (score=.816) EBI-912511, EBI-912440
    LPPENSP000003180893STRING (score=.942)
    AHDC1ENSP000002470873STRING (score=.925)
    COX6CENSP000002975643STRING (score=.918)
    RAD51L1ENSP000003405603STRING (score=.905)
    About this table

    5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325 establishment or maintenance of chromatin architecture TAS7606786
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent TAS7606786
    GO:0007049 cell cycle IEA--
    GO:0007067 mitosis IEA--
    About this table

    Drugs & Compounds
    for HMGA2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for HMGA2
    1 Novoseek chemical compound relationship for HMGA2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    dbds 55.24 1 11034995 (1)
    About this table


    Transcripts
    for HMGA2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (HMGA2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (HMGA2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003483

                  Sigma-Aldrich siRNA for HMGA2  
                         Sigma-Aldrich shRNA for HMGA2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003483  NM_003484  

    REFSEQ mRNAs for HMGA2 gene (2 alternative transcripts): 

    NM_003483.4   NM_003484.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003483  NM_003484  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003483
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003483
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001015886 

    Additional cDNA sequence: 

    AB209853.1 AF533652.1 AF533653.1 AF533654.1 AK311399.1 AK311443.1 AK311447.1 AY138860.1 
    AY387667.1 AY601861.1 AY601863.1 AY601864.1 AY601865.1 AY601866.1 AY601867.1 EU263623.1 
    U28749.1 U29112.1 U29113.1 U29114.1 U29115.1 U29120.1 Z31595.1 

    17 DOTS entries:

    DT.75106085  DT.70104951  DT.75184403  DT.95235329  DT.91741622  DT.75171619  DT.121179198  DT.121179242 
    DT.75167847  DT.100770504  DT.95368610  DT.121179237  DT.121179239  DT.91803500  DT.121179195  DT.92458188 
    DT.95222731 

    24/175 AceView cDNA sequences (see all 175 ):

    AA427962 BG120434 AU123955 BM905079 BU156305 AU151888 AI803639 AA375593 
    BM782659 BU739975 BU172379 BM715067 BU170551 BU166421 AI056193 CA422738 
    BM758678 CB143702 U29115 BM989530 AU129812 BQ213973 N44774 BU618588 

    highest scoring ESTs for HMGA2:

    AA064767 AA064824 AA074195 AA074701 AA093525 AA171531 AA171778 AA197282 AA205853 AA223259 

    Unigene Cluster for HMGA2:

    High mobility group AT-hook 2
    Hs.505924  [show with all ESTs]
    Unigene Representative Sequence: AB209853


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations:
    ENST00000393578  ENST00000354636  ENST00000393577  ENST00000403681  

    Expression
    for HMGA2

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    HMGA2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for HMGA2

    1 / 2 / 3

    11 probe-sets matching HMGA2 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    69224_at2, 3 U95-E 1 1.00 1.00 0.92 1.23 AI656540 0.80 1.00 0.91 1

    		35200_at2, 3 U95-A 1 1.00 1.00 0.78 0.78 X92518 0.80 0.88 0.84 1

    		638_at*2, 3 U95-A 1 -- -- 0.35 0.43 L46353 0.20 1.00 0.72 1

    		208025_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003483 0.60 1.00 0.82 1

    		1568287_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1559891_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1558682_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		208025_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1567224_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1558683_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1561633_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    GeneDecks  HMGA2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTGCACCGAG

    SOURCE GeneReport for Unigene cluster: Hs.505924

    Expression variation in blood from EXPOLDB for HMGA2

    Orthologs
    for HMGA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for HMGA2 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 HMGA21   -- high mobility group AT-hook 2 99.56(n)
    100(a)    		 744431  XM_001162933.1  XP_001162933.1 
    rat
    (Rattus norvegicus)    		 Hmga21   -- high mobility group AT-hook 2 91.9(n)
    94.39(a)    		 84017  NM_032070.1  NP_114459.1 
    mouse
    (Mus musculus)    		 Hmga21, 5 10 (67.50 cM)5
    		 high mobility group AT-hook 21, 5 92.9(n)1
    96.3(a)1    		 153641  NM_010441.21  NP_034571.11 
     AK0283465  AK0351645  (see all 25)
    chicken
    (Gallus gallus)    		 HMGA21   -- high mobility group AT-hook 2 82.87(n)
    91.74(a)    		 395851  NM_205001.1  NP_990332.1 
    zebrafish
    (Danio rerio)    		 hmga21   -- high mobility group AT-hook 2 71.3(n)
    77.78(a)    		 324428  NM_212680.1  NP_997845.1 
    About this table        Species with no ortholog for HMGA2

    ENSEMBL Gene Tree for HMGA2

    Paralogs
    for HMGA2

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for HMGA2 gene
    HMGA12  

    SNPs/Variants
    for HMGA2

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		UniProtKB/Swiss-Prot: HMGA2_HUMAN, P52926
    Polymorphism: Genetic variation in HMGA2 has been associated with stature as a quantitative trait
    (STQTL9) [MIM:611547]. Human height is a classic, highly heritable quantitative trait


    10/478 NCBI SNPs in HMGA2 are shown (see all 478 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 187)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs10427251,2
    		A,C,F,H64644614(+) TACAAT/CGAATT 1 -- ut3119Minor allele frequency- C:0.47MN EA NA EU WA 1836
    rs111759821,2
    		A,C,F,H64646335(+) CAAAAC/TAGATC 1 -- ut314Minor allele frequency- T:0.38EU EA WA 412
    rs79703501,2
    		A,C,F,H64646431(+) ATACTT/CCTTCA 1 -- ng316Minor allele frequency- C:0.48EU EA WA NA 558
    rs87561,2
    		A,C,F,H64646019(+) AGCTAA/CATAAG 1 -- ut3122Minor allele frequency- N:0.00EA NA NS MN EU WA 1488
    --
    rs65816581,2
    		A,C,F,H64503612(+) GGAACA/GTCGGA 2 -- ng514Minor allele frequency- G:0.20EU EA WA 412
    rs105064741,2
    		C,F,H64646541(+) AATTTT/CTACTT 1 -- ng3112Minor allele frequency- C:0.31NS EU EA WA NA 664
    rs20708081,2
    		A,C64504139(+) AGGGGA/TGACCT 2 -- ng51 tfbs30--------
    --
    rs72958761,2
    		A,C64503951(+) TCAGGC/GGACCT 2 -- ng510--------
    rs9686971,2
    		C,F64503938(+) CGGAGT/CACGGC 2 -- ng511Minor allele frequency- C:0.01MN 184
    rs23064361,2
    		F,H64595182(+) AATTGT/CCATTG 2 -- ut31 int1 ese35Minor allele frequency- C:0.01EA EU WA 1912
    About this table

    HapMap Linkage Disequilibrium images for HMGA2 (up to first 250kb)

    Disorders & Mutations
    for HMGA2

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 600698

    UniProtKB/Swiss-Prot: HMGA2_HUMAN, P52926

  • A chromosomal aberration involving HMGA2 is associated with a subclass of benign
    mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with LPP is shown in
    lipomas. HMGA2 is also fused with a number of other genes in lipomas
  • A chromosomal aberration involving HMGA2 is associated with pulmonary chondroid
    hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with LPP is detected in pulmonary chondroid
    hamartomas
  • A chromosomal aberration involving HMGA2 is associated with parosteal lipomas.
    Translocation t(3;12)(q28;q14) with LPP is also shown in one parosteal lipoma
  • A chromosomal aberration involving HMGA2 is found in uterine leiomyoma (UL) [MIM:150699].
    Translocation t(12;14)(q15;q23-24) with RAD51L1. Chromosomal rearrangements involving HMGA2 do not
    seem to be the principle pathobiological mechanism in uterine leiomyoma

    • 10/52 Novoseek disease relationships for HMGA2 gene (see all 52 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipoma 88.07 102 18663748 (5), 10329012 (5), 12781451 (5), 9212729 (4) (see all 47)
    uterine leiomyoma 82.29 54 12419585 (4), 11223542 (4), 10679920 (3), 10550310 (3) (see all 26)
    salivary gland adenoma, pleomorphic 80.73 2 8908160 (1), 17171686 (1)
    hamartoma 78.17 18 8637707 (2), 10744071 (2), 8603366 (1), 8780755 (1) (see all 15)
    adenoma pleomorphic 76.63 19 9484777 (4), 8988031 (3), 18604193 (2), 10347561 (1) (see all 12)
    benign tumor 72.00 17 10347561 (1), 11576996 (1), 15882911 (1), 15755872 (1) (see all 14)
    lipoma pleomorphic 70.81 3 8780755 (1), 8908160 (1), 15618963 (1)
    neoplastic transformation 67.41 3 18413806 (1), 16061642 (1), 14571323 (1)
    myxoma 66.12 13 11550285 (3), 16990720 (2), 16568309 (2), 11943015 (1) (see all 8)
    liposarcoma 63.81 7 14612541 (2), 11391797 (2), 17426251 (1), 17372913 (1)
    About this table

    Human Gene Mutation Database: HMGA2
    Human Genome Epidemiology Navigator: HMGA2 (7 documents)

    Medical News
    for HMGA2

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for HMGA2

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/246 PubMed articles for HMGA2 gene (see all 246 ):

    Search for HMGA2

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HMGA2

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 8091 HGNC: 5009 AceView: HMGA2 Ensembl:ENSG00000149948 euGenes: HUgn8091
    ECgene: HMGA2 H-InvDB: HMGA2

    Other Databases showing HMGA2

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing HMGA2

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for HMGA2 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for HMGA2

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for HMGA2

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for HMGA2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for HMGA2-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for HMGA2 Antibodies for HMGA2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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