Aliases for HMGCS1 Gene
Aliases for HMGCS1 Gene
- 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 2 3 5
- 3-Hydroxy-3-Methylglutaryl-Coenzyme A Synthase 1 (Soluble) 2 3
- 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Synthase 2 3
- 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) 2 3
- EC 2.3.3.10 4 61
- HMGCS 3 4
- Hydroxymethylglutaryl-CoA Synthase, Cytoplasmic 3
- 3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase 4
- HMG-CoA Synthase 4
External Ids for HMGCS1 Gene
- HGNC: 5007
- Entrez Gene: 3157
- Ensembl: ENSG00000112972
- OMIM: 142940
- UniProtKB: Q01581
Previous HGNC Symbols for HMGCS1 Gene
- HMGCS
Previous GeneCards Identifiers for HMGCS1 Gene
- GC05M043596
- GC05M044466
- GC05M043289
- GC05M043336
Summaries for HMGCS1 Gene
GeneCards Summary for HMGCS1 Gene
HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1) is a Protein Coding gene. Among its related pathways are Bisphosphonate Pathway, Pharmacodynamics and Sterol Regulatory Element-Binding Proteins (SREBP) signalling. GO annotations related to this gene include protein homodimerization activity and isomerase activity. An important paralog of this gene is HMGCS2.
UniProtKB/Swiss-Prot for HMGCS1 Gene
-
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGCS1 Gene
Genomics for HMGCS1 Gene
Regulatory Elements for HMGCS1 Gene
Enhancers for HMGCS1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G043482 | 1.2 | ENCODE | 10.5 | -171.5 | -171496 | 5.6 | CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 SP3 ZNF610 GLIS1 NBN | EEF1A1P19 ZNF131 RPL29P12 ENSG00000248240 NNT CCL28 ENSG00000249492 PAIP1 LOC153684 FGF10-AS1 |
| GH05G043389 | 1 | ENCODE | 11 | -76.4 | -76382 | 0.2 | FOXA2 ARNT ARID4B ZNF2 YY1 ZNF143 DEK REST PPARG ZNF518A | HMGCS1 NNT-AS1 CCL28 ENSG00000188850 |
| GH05G043396 | 1 | ENCODE dbSUPER | 10.9 | -83.5 | -83523 | 1.4 | GTF2F1 TAF1 SIN3A BMI1 RBBP5 RAD21 CHAMP1 YY1 E2F1 POLR2A | TMEM267 ENSG00000249492 HMGCS1 CCL28 ENSG00000188850 |
| GH05G043281 | 0.7 | ENCODE | 11.6 | +31.4 | 31412 | 1.1 | PKNOX1 JUN BACH1 FOSL1 ZNF316 ARID3A GATA2 FOS NFE2 MAFK | HMGCS1 NNT ENSG00000261604 LOC100419036 |
| GH05G043232 | 0.7 | ENCODE | 10.8 | +81.3 | 81279 | 0.2 | CTCF PKNOX1 MAX REST RAD21 YY1 FOXA1 HIC1 ATF3 PBX2 | HMGCS1 NIM1K GC05P043232 ENSG00000249888 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HMGCS1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HMGCS1 Gene
- Chromosome:
- 5
- Start:
- 43,287,470 bp from pter
- End:
- 43,313,512 bp from pter
- Size:
- 26,043 bases
- Orientation:
- Minus strand
Genomic View for HMGCS1 Gene
Genes around HMGCS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p12 by Ensembl
- 5p12 by Entrez Gene
- 5p12 by HGNC
HMGCS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMGCS1 Gene
Proteins for HMGCS1 Gene
-
Protein details for HMGCS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01581-HMCS1_HUMAN
- Recommended name:
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Protein Accession:
- Q01581
- B2RDL8
Protein attributes for HMGCS1 Gene
- Size:
- 520 amino acids
- Molecular mass:
- 57294 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH00297.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for HMGCS1 Gene
Selected DME Specific Peptides for HMGCS1 Gene
- Q01581:
-
- GKYTIGLG
- APDVFAENMK
- EHIPSPAKKVPR
- QCYLSALD
- VDGKLSIQCYL
- VQKSLAR
- LMQLFEESGNTD
- LIGPNAP
- GNARPTGG
- ESSSWDGRYA
- MQHAYDFYKPD
- VKLEDTYFDR
- TNACYGGTA
- DKSKSVK
- LFEGTWYLVRVDEKHRRTYARRP
- WDGRYALVV
- FPSQYVDQ
Post-translational modifications for HMGCS1 Gene
Other Protein References for HMGCS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for HMGCS1 (HMGCS1)
-
Custom Antibody ServicesOriGene Antibodies for HMGCS1
- Novus Biologicals Antibodies for HMGCS1
-
Cloud-Clone Corp. Antibodies for HMGCS1
- Invitrogen Antibodies for HMGCS1
- antibodies-online Antibodies for HMGCS1: See all 45
- GeneTex HMGCS1 antibody for HMGCS1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HMGCS1
Protein Products
-
OriGene Purified Proteins for HMGCS1
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGCS1
- Origene Custom Protein Services for HMGCS1
- ProSpec Recombinant Proteins for HMGCS1
-
Cloud-Clone Corp. Proteins for HMGCS1
- antibodies-online Proteins for HMGCS1: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HMGCS1
Domains & Families for HMGCS1 Gene
Gene Families for HMGCS1 Gene
- IUPHAR :
Protein Domains for HMGCS1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMGCS1 Gene
Graphical View of Domain Structure for InterPro Entry
Q01581- Family:
-
- Belongs to the HMG-CoA synthase family.
Function for HMGCS1 Gene
Molecular function for HMGCS1 Gene
- GENATLAS Biochemistry:
- 3-hydroxy-3-methylglutaryl-CoA synthase 1,cytoplasmic
- UniProtKB/Swiss-Prot CatalyticActivity:
- Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
- UniProtKB/Swiss-Prot Function:
- This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Enzyme Numbers (IUBMB) for HMGCS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004421 | hydroxymethylglutaryl-CoA synthase activity | IEA,TAS | -- |
| GO:0008144 | drug binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016853 | isomerase activity | IEA | -- |
Phenotypes for HMGCS1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for HMGCS1
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGCS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGCS1 gene
- Search ViGene Biosciences for HMGCS1
CRISPR Products
-
OriGene CRISPR knockouts for HMGCS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGCS1
- GenScript: Design CRISPR guide RNA sequences for HMGCS1
miRNA for HMGCS1 Gene
- miRTarBase miRNAs that target HMGCS1
-
- hsa-mir-335-5p (MIRT017138)
- hsa-mir-186-5p (MIRT021092)
- hsa-mir-192-5p (MIRT026269)
- hsa-mir-96-5p (MIRT027892)
- hsa-mir-19b-3p (MIRT031085)
- hsa-mir-18a-5p (MIRT031353)
- hsa-mir-1301-3p (MIRT035970)
- hsa-mir-769-3p (MIRT039071)
- hsa-mir-92a-3p (MIRT049260)
- hsa-let-7b-5p (MIRT052336)
- hsa-mir-3176 (MIRT052793)
- hsa-mir-210-3p (MIRT440491)
- hsa-mir-155-5p (MIRT440492)
- hsa-mir-2113 (MIRT493590)
- hsa-mir-1305 (MIRT493591)
- hsa-mir-607 (MIRT493592)
- hsa-mir-147b (MIRT493593)
- hsa-mir-23c (MIRT493594)
- hsa-mir-23b-3p (MIRT493595)
- hsa-mir-23a-3p (MIRT493596)
- hsa-mir-130a-5p (MIRT493597)
- hsa-mir-5087 (MIRT493598)
- hsa-mir-6506-3p (MIRT493599)
- hsa-mir-548s (MIRT567313)
- hsa-mir-3926 (MIRT567314)
- hsa-mir-202-3p (MIRT567315)
- hsa-mir-4670-3p (MIRT567316)
- hsa-mir-4797-5p (MIRT567317)
- hsa-mir-583 (MIRT567318)
- hsa-mir-8055 (MIRT667946)
- hsa-mir-1304-5p (MIRT667947)
- hsa-mir-6858-5p (MIRT667948)
- hsa-mir-4689 (MIRT667949)
- hsa-mir-3915 (MIRT667950)
- hsa-mir-1224-5p (MIRT667951)
- hsa-mir-4279 (MIRT667952)
- hsa-mir-6881-3p (MIRT667953)
- hsa-mir-4784 (MIRT667954)
- hsa-mir-3150b-3p (MIRT667955)
- hsa-mir-877-3p (MIRT667956)
- hsa-mir-660-3p (MIRT667957)
- hsa-mir-5193 (MIRT667958)
- hsa-mir-3184-3p (MIRT667959)
miRNA Products
- Search ViGene Biosciences for HMGCS1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HMGCS1
- Browse OriGene Inhibitory RNA Products For HMGCS1
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGCS1 gene
Clone Products
- Sino Biological Human cDNA Clone for HMGCS1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HMGCS1
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for HMGCS1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGCS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGCS1 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMGCS1 Gene
Localization for HMGCS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMGCS1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 3 |
| nucleus | 3 |
| mitochondrion | 2 |
| extracellular | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | TAS | 7913309 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for HMGCS1 Gene
Pathways by source for HMGCS1 Gene
1 Cell Signaling Technology pathway for HMGCS1 Gene
8 BioSystems pathways for HMGCS1 Gene
1 PharmGKB pathway for HMGCS1 Gene
UniProtKB/Swiss-Prot Q01581-HMCS1_HUMAN
- Pathway: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
Interacting Proteins for HMGCS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001889 | liver development | IEA | -- |
| GO:0006629 | lipid metabolic process | NAS | 7913309 |
| GO:0006694 | steroid biosynthetic process | IEA | -- |
| GO:0006695 | cholesterol biosynthetic process | TAS | -- |
| GO:0007420 | brain development | IEA | -- |
No data available for SIGNOR curated interactions for HMGCS1 Gene
Drugs & Compounds for HMGCS1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Water | Approved | Pharma | 0 | |||
| (3R,5S,7R,12S,13R)-13-FORMYL-12,14-DIHYDROXY-3,5,7-TRIMETHYLTETRADECANOIC ACID | Experimental | Pharma | Target | 0 | ||
| Acetoacetyl-CoA | Experimental | Pharma | 0 | |||
| (S)-3-hydroxy-3-methylglutaryl-CoA | Pharma | Feedback inhibition, Inhibitor | 0 | |||
| Coenzyme A | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coa |
|
1553-55-5 |
|
|||
| acetyl-coa |
|
72-89-9 |
|
Transcripts for HMGCS1 Gene
mRNA/cDNA for HMGCS1 Gene
- (10) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (315) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HMGCS1 Gene
- 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for HMGCS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGCS1
- GenScript: Design CRISPR guide RNA sequences for HMGCS1
miRNA Products
- Search ViGene Biosciences for HMGCS1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HMGCS1
- Browse OriGene Inhibitory RNA Products For HMGCS1
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGCS1 gene
Clone Products
- Sino Biological Human cDNA Clone for HMGCS1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HMGCS1
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - |
Expression for HMGCS1 Gene
This gene is overexpressed in Fetal Liver (13.2), Cervix (9.7), Fetal testis (7.6), and Fetal Brain (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMGCS1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HMGCS1 Gene:
HMGCS1SOURCE GeneReport for Unigene cluster for HMGCS1 Gene:
Hs.397729Evidence on tissue expression from TISSUES for HMGCS1 Gene
- Liver(4.8)
- Nervous system(4.8)
- Lung(4.4)
- Adrenal gland(4.3)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for HMGCS1
-
OriGene qPCR primer pairs and template standards for HMGCS1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGCS1 Gene
Orthologs for HMGCS1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMGCS1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| HMGCS1 34 |
|
||||
| -- 35 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | HMGCS1 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HMGCS1 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HMGCS1 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hmgcs1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hmgcs1 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | HMGCS1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HMGCS1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hmgcs1 34 |
|
||
| Str.15315 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | hmgcs1-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hmgcs1 34 35 |
|
||
| zgc56481 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Hmgs 36 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005847 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | hmgs-1 35 |
|
OneToMany | |
| F25B4.6 36 |
|
|
|||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D10505g 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ERG13 34 35 37 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADL356C 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | MVA1 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0118800 34 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.4542 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03922 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | hcs1 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9481 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.13852 34 |
|
- Species where no ortholog for HMGCS1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HMGCS1 Gene
(1) SIMAP similar genes for HMGCS1 Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for HMGCS1 Gene
Variants for HMGCS1 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000301603 | -- | 43,287,805(+) | ACAGC(G/T)AGAAT | utr-variant-3-prime | |
| rs1000586255 | -- | 43,303,138(+) | TTCTT(C/T)AGATA | intron-variant | |
| rs1000606372 | -- | 43,290,639(+) | ACCAC(A/G)TTTTA | utr-variant-3-prime | |
| rs1000729894 | -- | 43,306,155(+) | GACAA(A/G)AGAAA | intron-variant | |
| rs1000771758 | -- | 43,310,513(+) | AAGGG(C/T)ACTCA | intron-variant |
Residual Variation Intolerance Score:
30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.14;
23.14% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HMGCS1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HMGCS1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGCS1 Gene
Disorders for HMGCS1 Gene
Relevant External Links for HMGCS1
No disorders were found for HMGCS1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMGCS1 Gene
Publications for HMGCS1 Gene
- Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design. (PMID: 20346956) Shafqat N. … Yue W.W. (J. Mol. Biol. 2010) 3 22 64
- Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PMID: 18636124) Skibola C.F. … Smith M.T. (PLoS ONE 2008) 3 46 64
- Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y. … Boer J.M. (J. Lipid Res. 2008) 3 46 64
- Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP. (PMID: 19088433) Vock C. … Nitz I. (Cell. Physiol. Biochem. 2008) 3 22 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
Products for HMGCS1 Gene
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- OriGene qPCR primer pairs and template standards for HMGCS1
- OriGene qPCR primer pairs for HMGCS1
- OriGene CRISPR knockouts for HMGCS1
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for HMGCS1 in any vector
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- GenScript: Design CRISPR guide RNA sequences for HMGCS1
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- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological Proteins
- Sino Biological Antibodies
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- Novus Biologicals Antibodies for HMGCS1
- Novus Biologicals proteins and lysates for HMGCS1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for HMGCS1
- Cloud-Clone Corp. Antibodies for HMGCS1
- Cloud-Clone Corp. Proteins for HMGCS1
- Cloud-Clone Corp Assay Kits for HMGCS1
- Taconic Biosciences Mouse Models for HMGCS1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Addgene plasmids for HMGCS1
- antibodies-online Antibodies for HMGCS1: See all 45
- antibodies-online Kits for HMGCS1: See all 14
- antibodies-online Proteins for HMGCS1: See all 7
- Search antibodies-online for peptides
- GeneTex HMGCS1 antibody for HMGCS1
- Search GeneTex for Proteins for HMGCS1
- ViGene Biosciences adenoviral particle packaged cDNA for HMGCS1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HMGCS1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HMGCS1 gene
- Search ViGene Biosciences for HMGCS1
- Santa Cruz Biotechnology (SCBT) Antibodies for HMGCS1
- Search Santa Cruz Biotechnology (SCBT) for HMGCS1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HMGCS1
- Cyagen custom Knockout/knockin (KOKI) mouse models for HMGCS1
- VectorBuilder custom plasmid, inducible vectors for HMGCS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMGCS1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HMGCS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
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- (127) Disease Ontology
- (128) Genetics Home Reference
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- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer